DOCSLIB.ORG

Mosier, Oregon – June 3, 2016 Derailment Site Assessment Report

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Mosier, Oregon – June 3, 2016 Derailment Site Assessment Report Mosier, Oregon – June 3, 2016 Derailment Site Assessment Report Union Pacific Railroad Company Prepared for Oregon Department of Environmental Quality October 28, 2016 2020 SW 4th Ave, Suite 300 Portland, OR 97201 Contents Section Page Acronyms and Abbreviations ............................................................................................................... v 1 Introduction ......................................................................................................................... 1-1 1.1 Site Description ................................................................................................................ 1-2 1.2 Nature of Release ............................................................................................................ 1-2 2 Emergency Response Procedures .......................................................................................... 2-1 2.1 Columbia River Response Actions.................................................................................... 2-1 2.2 Derailed Tank Car Removal and Track Repair .................................................................. 2-1 2.3 City of Mosier Wastewater Treatment Plant Response Actions ..................................... 2-1 3 Incident Command Sampling ............................................................................................... 3-1 3.1 Surface Water Sampling .................................................................................................. 3-1 3.1.1 Surface Water Grab Sampling ............................................................................ 3-1 3.1.2 OSU Diffusion Bag Sampling ............................................................................... 3-2 3.1.3 Surface Water Analytical Results ........................................................................ 3-2 3.2 Sediment Sampling .......................................................................................................... 3-3 3.2.1 Sediment Sampling Approach ............................................................................. 3-3 3.2.2 Sediment Analytical Results ................................................................................ 3-3 3.3 Groundwater Sampling .................................................................................................... 3-3 3.3.1 Groundwater Sampling Approach ...................................................................... 3-4 3.3.2 Groundwater Analytical Results ......................................................................... 3-4 3.4 Soil Sampling .................................................................................................................... 3-4 3.4.1 Initial Excavation and Confirmation Soil Samples ............................................... 3-5 3.4.2 Additional Soil Removal and Confirmation Sample Collection ........................... 3-5 3.5 Other Response Action Sampling .................................................................................... 3-5 3.5.1 Pothole Soil Sampling Near Manhole ................................................................. 3-5 3.5.2 Mainline Track Confirmation Soil Sampling ........................................................ 3-6 4 Biosparge Treatment System ................................................................................................ 4-1 4.1 Treatment System Design ................................................................................................ 4-1 4.2 Startup ............................................................................................................................. 4-1 4.3 Operation Monitoring ...................................................................................................... 4-2 5 Future Site Actions ............................................................................................................... 5-1 5.1 Surface Water Sampling at Rock Creek and Wetland ...................................................... 5-1 5.2 Groundwater Sampling .................................................................................................... 5-1 5.3 Soil Gas Surveying ............................................................................................................ 5-1 5.4 Biosparge Operations ...................................................................................................... 5-1 5.5 Site Restoration ............................................................................................................... 5-1 Appendixes A Spill Report and Incident Command Sampling Plan B Representative Site Photographs C OSU Passive Sampling Device SAP and Final Report D Previous Surface Water Sample Results E Laboratory Analytical Data Packages CONTENTS, CONTINUED F Boring Logs G Previous Groundwater Sample Results Tables 3-1 Columbia River and Rock Creek Surface Water Sample Results (September 7, 2016) 3-2 Columbia River Sediment Sample Results 3-3 Rock Creek Sediment Sample Results 3-4 Groundwater Sample Results (September 8 and 9, 2016) 3-5 Initial Confirmation Soil Sample Results (Soil Later Removed) 3-6 Final Confirmation Soil Sample Results (Characteristic of Soil Left in Place) 3-7 Pothole Soil Sample Results near WWTP Manhole 3-8 Mainline Track Confirmation Soil Sample Results 3-9 Miscellaneous Soil Sample Results Figures 1-1 Site Features 1-2 Initial Response Actions 3-1 Surface Water Sampling Locations 3-2 Sediment Sampling Locations 3-3 Soil Confirmation Samples in Excavation Area (NWTPH-Dx/Gx Results) 3-4 Pothole and Mainline Track Sample Locations 4-1 Biosparge System Layout IV EN1011161111PDX Acronyms and Abbreviations µg/kg microgram(s) per kilogram µg/L microgram(s) per Liter AIS air injection system BTEX benzene, toluene, ethylbenzene, and xylene DEQ Oregon Department of Environmental Quality Dx diesel range organics Gx gasoline range organics Hz hertz I-84 Interstate 84 ICS Incident Command System MDL method detection limit mg/kg milligram(s) per kilogram mg/L milligram(s) per Liter NOAA National Oceanic Atmospheric Administration NS near shore O oil range organics ORP oxidation reduction potential OS off shore OSU Oregon State University PAH polycyclic aromatic hydrocarbon PID photo-ionization detector ppm parts per million PSD passive sampling device PVC polyvinyl chloride SAP sampling and analysis plan TPH total petroleum hydrocarbon UPRR Union Pacific Railroad Company VFD variable frequency drive VOC volatile organic compound WWTP wastewater treatment plant SECTION 1 1 Introduction This site assessment report presents the results of surface water, sediment, wastewater treatment plant (WWTP) water, soil, and groundwater samples collected by Union Pacific Railroad Company (UPRR) in response to a derailment that resulted in a Bakken crude oil release on June 3, 2016. This site assessment report presents a summary of response measures implemented, remedial actions implemented, and the methods and rationale for the various media sampled. The report also presents information on the air biosparge treatment system installed at the site to treat groundwater in the vicinity of the release. The report is organized as follows: • Section 1.0 Introduction: This section describes the site conditions, spill location, and the nature of the release. • Section 2.0 Emergency Response Procedures: This section presents a summary of cleanup efforts conducted in response to the release. The primary efforts included initial fire response, Columbia River response actions, removal of damaged tank cars, the City of Mosier WWTP response actions, and impacted soil removal efforts. • Section 3.0 Incident Command System Sampling: This section presents the incident command system’s sampling approach and analytical results for different media including surface water, sediment, soil, WWTP water, and groundwater. • Section 4.0 Biosparge Treatment System: This section discusses the treatment system installed to treat impacted groundwater north of the release area. • Section 5.0 Future Site Actions: This section discusses future actions to be completed at the site. • Appendix A Spill Report and Incident Command Sampling Plan: This appendix contains a report that summarizes the nature of the spill, initial reporting, extent of cleanup measures implemented, and incident command sampling plan. • Appendix B Representative Site Photographs: This appendix contains representative photographs taken during the spill response and subsequent cleanup. • Appendix C Oregon State University (OSU) Passive Bag Sampling and Analysis Plan (SAP) and Final Report: This appendix includes documents developed by third-party contractor, OSU, detailing the results of deploying passive diffusion bag samplers in the Columbia River near the WWTP outfall. • Appendix D Previous Surface Water Sample Results: This appendix contains surface water sampling results pre-dating those presented in the main body of this report (prior to September 7, 2016). Comparison tables of the analytical results from the grab sampling and the OSU sampling are also presented in this appendix. • Appendix E Laboratory Analytical Data Packages: This appendix contains the laboratory analytical data packages for the samples collected in conjunction with the cleanup efforts. • Appendix F Boring Logs: Boring logs for MW-1 to MW-8, EW-1, EW-2, and BS-1 to BS-5 are included in this appendix. • Appendix G Previous Groundwater Sample Results: Groundwater sampling results prior to those presented in the main body
Load more

Recommended publications
  • Development of Microplate Screening System
    DEVELOPMENT OF MICROPLATE SCREENING SYSTEM AND CONSTRUCTION OF FLUORESCEIN-BASED LIBRARY FENG SUIHAN A THESIS SUMBITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF CHEMISTRY NATIONAL UNIVERSITY OF SINGAPORE 2010 Acknowledgements First of all, I would like to express my deep gratitude to my supervisor, Associate Professor Young-Tae Chang for his profound knowledge, invaluable guidance, constant support and inspiration throughout my graduate studies. The knowledge, both scientific and otherwise, that I accumulated under his supervision, will aid me greatly throughout my life. Next, I would like to give my sincere thanks to Dr. Marc Vendrell and Dr. Hyung-Ho Ha, for their warm support during my entire graduate studies. Besides, my sincere thinks goes to Miss Siqiang Yang, who helped me to set up the microplate screening platform. Also, I would like to thank all the graduate students of Chang lab, Animesh, Duanting, Ghosh, Jun-Seok, Yun-Kyung, Raj, for their cordiality and friendship. We had a great time together. I also benefited from all other lab members, particularly but not limited to, Siti, Yee Ling, Chew Yan, Xubin, Jeffrey, Shin Hui, Dr. Bi, Dr. Cho, Dr. Jun Li, Dr. Lees, Dr. Kang, Dr. Kim, Dr. Park, and etc. Thanks for making the working place an enjoyable one. I am grateful to Dr. Tan for recruiting me into NUS Medicinal Chemistry graduate program and I am also thankful to NUS for awarding me the research scholarship. At last, I would like to express greatest thanks to my family, particularly my wife, Bai Yang, whose encourage and understanding help me to finish my graduate study in NUS.
    [Show full text]
  • Drug-Like Properties and ADME of Xanthone Derivatives: the Antechamber of Clinical Trials Ana Sara Gomes, Pedro Brandão, Carla
    Drug-like properties and ADME of xanthone derivatives: the antechamber of clinical trials Ana Sara Gomes, Pedro Brandão, Carla Fernandes, Marta Correia-da-Silva, Emília Sousa*, Madalena Pinto# # all authors contributed equally to this work *corresponding author Abstract Xanthone derivatives have been described as compounds with privileged scaffolds that exhibited diverse interesting biological activities, such as antitumor activity, directing the interest to pursue the development of these derivatives into drug candidates. Nevertheless, to achieve this purpose it is crucial to study their pharmacokinetics and toxicity (PK/tox) as decision endpoints to continue or interrupt the development investment. This review aims to expose the most relevant analytical methods used in physicochemical and PK/tox studies in order to detect, quantify and identify different bioactive xanthones. Also the methodologies used in the mentioned studies, and the main obtained results, are referred to understand the drugability of xanthones derivatives through in vitro and in vivo systems towards ADME/tox properties, such as physicochemical and metabolic stability and biovailability. The last section of this review focus on a case-study of the development of the drug candidate DMXAA, which has reached clinical trials, to understand the paths and the importance of PK/tox studies. In the end, the data assembled in this review intends to facilitate the design of potential drug candidates with a xanthonic scaffold. Xanthone; analytical method; drug-like; pharmacokinetics; toxicity; drug development; preclinical; metabolism; chromatography. 1. Introduction The xanthone nucleus or 9H-xanthen-9-one (dibenzo-γ-pirone 1, Fig. 1) comprises an important class of oxygenated heterocycles and is considered a privileged structure 1.
    [Show full text]
  • Acetylcholinesterase
    AChE Acetylcholinesterase Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase. www.MedChemExpress.com 1 AChE Inhibitors & Activators (+)-Phenserine (-)-Corynoxidine Cat. No.: HY-16009 Cat. No.: HY-N7010 (+)-Phenserine is a novel selective cholinesterase (-)-Corynoxidine is an acetylcholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM. inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. Purity: 98.09% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 1 mg, 5 mg (-)-Huperzine A (R)-Rivastigmine D6 tartrate (Huperzine A) Cat. No.: HY-17387 Cat. No.: HY-11017AS (-)-Huperzine A (Huperzine A) is an alkaloid (R)-Rivastigmine D6 tartrate is the deuterium isolated from a Chinese club moss, with labeled (R)-Rivastigmine, which is an neuroprotective activity.
    [Show full text]
  • WO 2015/017328 A2 5 February 2015 (05.02.2015) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2015/017328 A2 5 February 2015 (05.02.2015) P O P C T (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A 57/20 (2006.01) A61K 31/661 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, A 57/12 (2006.01) A61N 5/06 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, A61K 31/662 (2006.01) HN, HR, HU, ID, JL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, (21) International Application Number: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, PCT/US20 14/048420 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (22) International Filing Date: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 28 July 2014 (28.07.2014) TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, 61/859,572 29 July 2013 (29.07.2013) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 61/861,072 1 August 2013 (01 .08.2013) US TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 61/953,290 14 March 2014 (14.03.2014) u s EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (72) Inventor; and TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (71) Applicant : SPALLITTA, Frank Anthony [US/US]; KM, ML, MR, NE, SN, TD, TG).
    [Show full text]
  • Human & Experimental Toxicology
    Human & Experimental Toxicology http://het.sagepub.com/ Environmental toxins: Alarming impacts of pesticides on male fertility Pallav Sengupta and Rajdeb Banerjee Hum Exp Toxicol 2014 33: 1017 originally published online 17 December 2013 DOI: 10.1177/0960327113515504 The online version of this article can be found at: http://het.sagepub.com/content/33/10/1017 Published by: http://www.sagepublications.com Additional services and information for Human & Experimental Toxicology can be found at: Email Alerts: http://het.sagepub.com/cgi/alerts Subscriptions: http://het.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav >> Version of Record - Oct 15, 2014 OnlineFirst Version of Record - Dec 17, 2013 What is This? Downloaded from het.sagepub.com by guest on October 15, 2014 Article Human and Experimental Toxicology 2014, Vol. 33(10) 1017–1039 ª The Author(s) 2013 Environmental toxins: Alarming Reprints and permission: sagepub.co.uk/journalsPermissions.nav impacts of pesticides on male fertility DOI: 10.1177/0960327113515504 het.sagepub.com Pallav Sengupta1 and Rajdeb Banerjee2 Abstract This review comprehensively summarizes the effects of more than 15 mostly used pesticides on male repro- ductive physiology, as recent experimental and epidemiological research have indicated their alarming impact on overall human health. Mechanisms have described that pesticide exposure damages spermatozoa, alter Ser- toli or Leydig cell function, both in vitro and in vivo and thus affects semen quality. But, the literature suggests a need for more intricate research in those pesticides that are defined as mutagens or carcinogens and directly affect the hypothalamic–pituitary–gonadal axis.
    [Show full text]
  • A Journey Through the World of Xanthones
    molecules Review From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones Madalena M. M. Pinto 1,2,* , Andreia Palmeira 1,2,†, Carla Fernandes 1,2,† , Diana I. S. P. Resende 1,2,† , Emília Sousa 1,2,† , Honorina Cidade 1,2,† , Maria Elizabeth Tiritan 1,2,3,† , Marta Correia-da-Silva 1,2,† and Sara Cravo 1,2,† 1 Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; [email protected] (A.P.); [email protected] (C.F.); [email protected] (D.I.S.P.R.); [email protected] (E.S.); [email protected] (H.C.); [email protected] (M.E.T.); [email protected] (M.C.-d.-S.); [email protected] (S.C.) 2 Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal 3 CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal * Correspondence: [email protected]; Tel.: +351-966-092-514 † These authors (by alphabetic order) contributed equally to this work. Abstract: This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistry concerning the isolation from plant and marine sources of xanthone derivatives as well as their synthesis, biological/pharmacological activities, formulation and analytical applications. Although her group activity has been spread over several chemical families with relevance in Medicinal Chemistry, the main focus of the investigation and research has Citation: Pinto, M.M.M.; Palmeira, been in the xanthone family.
    [Show full text]
  • Introduction (Pdf)
    Dictionary of Natural Products on CD-ROM This introduction screen gives access to (a) a general introduction to the scope and content of DNP on CD-ROM, followed by (b) an extensive review of the different types of natural product and the way in which they are organised and categorised in DNP. You may access the section of your choice by clicking on the appropriate line below, or you may scroll through the text forwards or backwards from any point. Introduction to the DNP database page 3 Data presentation and organisation 3 Derivatives and variants 3 Chemical names and synonyms 4 CAS Registry Numbers 6 Diagrams 7 Stereochemical conventions 7 Molecular formula and molecular weight 8 Source 9 Importance/use 9 Type of Compound 9 Physical Data 9 Hazard and toxicity information 10 Bibliographic References 11 Journal abbreviations 12 Entry under review 12 Description of Natural Product Structures 13 Aliphatic natural products 15 Semiochemicals 15 Lipids 22 Polyketides 29 Carbohydrates 35 Oxygen heterocycles 44 Simple aromatic natural products 45 Benzofuranoids 48 Benzopyranoids 49 1 Flavonoids page 51 Tannins 60 Lignans 64 Polycyclic aromatic natural products 68 Terpenoids 72 Monoterpenoids 73 Sesquiterpenoids 77 Diterpenoids 101 Sesterterpenoids 118 Triterpenoids 121 Tetraterpenoids 131 Miscellaneous terpenoids 133 Meroterpenoids 133 Steroids 135 The sterols 140 Aminoacids and peptides 148 Aminoacids 148 Peptides 150 β-Lactams 151 Glycopeptides 153 Alkaloids 154 Alkaloids derived from ornithine 154 Alkaloids derived from lysine 156 Alkaloids
    [Show full text]
  • Insect Problems That Develop on Alfalfa Following Treatment with Certain Insecticides1
    INSECT PROBLEMS THAT DEVELOP ON ALFALFA FOLLOWING TREATMENT WITH CERTAIN INSECTICIDES1 M. CURTIS WILSON AND RALPH L. DAVIS Departments of Entomology and Agronomy, Purdue University Agricultural Experiment Station, Lafayette, Indiana Since the close of World War II many new organic insecticides have been developed and released by manufacturers. In experimental tests, many have proved to give more effective control of certain insect pests than do materials previously recommended. Others need further investigation of their effects on Insects, on plants, and on man before their use can be recommended. The indiscriminate use of many of the new organic insecticides may create more serious problems than is generally recognized. DDT had been used only a short time when investigators began reporting such strange effects as the buildup of certain insect populations, creating new problems more serious than the problem before treatment. This was particularly true with certain aphids and mites. Serious aphid Increases have been reported by Stevenson et aL (1944), Loft in (1944), Baker, Howard, and Porter (1945), Eberling (1945), Hervey (1946), Newcomer, Dean, and Carlson (1946), Wheeler and LaPlante (1946), and Sylvester (1949) following the use of DDT. Mite increases have been reported by Loftin (1944), Eberling (1945), Gray (1945), Hough (1946), Driggers (1946), Michelbacker et al. (1946), Wheeler and LaPlante (1946), and DeBach (1947). Increases in scale insects have been reported by Woglum (1946), Middlekauff et al. (1947), and Michel- backer et al. (1947). Wilson (1949) reported increased populations of potato leafhoppers, Empoasca fabae (Harris), following treatment with chlordane. DDT and other new organics are not the first insecticides reported to effect an increase in the population of certain insects following their use.
    [Show full text]
  • Mangosteen Pericarp and Its Bioactive Xanthones
    International Journal of Molecular Sciences Review Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer’s Disease, Parkinson’s Disease, and Depression with Pharmacokinetic and Safety Profiles Ha Thi Thu Do and Jungsook Cho * College of Pharmacy, Dongguk University-Seoul, Dongguk-ro 32, Ilsandong-gu, Goyang, Gyeonggi 10326, Korea; [email protected] * Correspondence: [email protected] Received: 27 July 2020; Accepted: 25 August 2020; Published: 27 August 2020 Abstract: Alzheimer’s disease (AD), Parkinson’s disease (PD), and depression are growing burdens for society globally, partly due to a lack of effective treatments. Mangosteen (Garcinia mangostana L.,) pericarp (MP) and its xanthones may provide therapeutic advantages for these disorders. In this review, we discuss potential therapeutic value of MP-derived agents in AD, PD, and depression with their pharmacokinetic and safety profiles. MP-derived agents have shown multifunctional effects including neuroprotective, antioxidant, and anti-neuroinflammatory actions. In addition, they target specific disease pathologies, such as amyloid beta production and deposition as well as cholinergic dysfunction in AD; α-synuclein aggregation in PD; and modulation of monoamine disturbance in depression. Particularly, the xanthone derivatives, including α-mangostin and γ-mangostin, exhibit potent pharmacological actions. However, low oral bioavailability and poor brain penetration may limit their therapeutic applications. These challenges can be overcome in part by administering as a form of MP extract (MPE) or using specific carrier systems. MPE and α-mangostin are generally safe and well-tolerated in animals. Furthermore, mangosteen-based products are safe for humans. Therefore, MPE and its bioactive xanthones are promising candidates for the treatment of AD, PD, and depression.
    [Show full text]
  • EICG-Hot Spots: EICG Appendix C
    [Note: The pre-existing regulation text is set forth below in normal type. The original proposed amendments are shown in underline to indicate additions and strikethrough to indicate deletions. Additional proposed modifications are shown in double underline to indicate additions and double strikethrough to indicate deletions. The square brackets “[ ]” are used to indicate minor adjustments to text (e.g., page numbers and adoption dates) that will be updated upon adoption of the proposed amendments.] APPENDIX C FACILITY GUIDELINE INDEX (FACILITY "LOOK-UP" TABLE) This Page Intentionally Left Blank APPENDIX C - I RESPONSIBILITIES OF ALL FACILITIES NOTES FOR APPENDIX CFACILITY GUIDELINE INDEX APPENDIX C‑I RESPONSIBILITIES OF ALL FACILITIES NOTHING IN THIS APPENDIX SHALL BE CONSTRUED AS REQUIRING THAT SOURCE TESTING BE CONDUCTED FOR SUBSTANCES SET FORTH IN THIS APPENDIX. FURTHER, IN CASES WHERE A SUBSTANCE SET FORTH HEREIN IS NOT PRESENT AT A PARTICULAR FACILITY, THE FACILITY OPERATOR SHALL NOT ATTEMPT TO QUANTIFY THE EMISSIONS OF SUCH SUBSTANCE, BUT SHALL PROVIDE ADEQUATE DOCUMENTATION TO DEMONSTRATE TO THE DISTRICT THAT THE POSSIBLE PRESENCE OF THE SUBSTANCE AT THE FACILITY HAS BEEN ADDRESSED AND THAT THERE ARE NO EMISSIONS OF THE SUBSTANCE FOR SPECIFIED REASONS. Substances emitted by a particular device or process may not be limited to those listed in this Facility Guideline Index. THIS APPENDIX IS NOT AN EXHAUSTIVE LIST. ALL FACILITIES ARE RESPONSIBLE FOR IDENTIFYING AND ACCOUNTING FOR ANY LISTED SUBSTANCE USED, MANUFACTURED, FORMULATED, OR RELEASED. This Facility Guideline Index is arranged in alphabetical order. The first part of the index, Appendix C‑I, lists devices common to many industries and the second part of the index, Appendix C‑II, lists industry types.
    [Show full text]
  • Xanthone and Flavone Derivatives As Potential Dual Agents for Alzheimer’S Disease
    Xanthone and Flavone Derivatives as Potential Dual Agents for Alzheimer’s Disease Maria Inês Alves de Sousa Cruz Dissertation presented to the Faculdade de Farmácia da Universidade do Porto, to obtain the degree of Master in Pharmaceutical Chemistry Work developed under the scientific supervision of Professor Madalena Maria de Magalhães Pinto and Professor Honorina Maria de Matos Cidade July 2015 IN ACCORDANCE WITH THE APPLICABLE LAW, IS NOT ALLOWED TO REPRODUCE ANY PART OF THIS THESIS. ii This work was developed in the “Centro de Química Medicinal-Universidade do Porto” (CEQUIMED-UP), Laboratório de Química Orgânica e Farmacêutica, Departamento de Química, Faculdade de Farmácia, Universidade do Porto. This research was partially supported by the Strategic Funding UID/Multi/04423/2013 through national funds provided by FCT – Foundation for Science and Technology and European Regional Development Fund (ERDF), in the framework of the programme PT2020 and by the Project PEst-OE/SAU/UI4040/2014(FCT). iii Poster Communications - Original research Some results presented in this dissertation are part of the following abstracts and poster communications: Maria Inês S. Cruz*, Sara M. Cravo, Honorina Cidade, Madalena Pinto, “Xanthone derivatives with potential dual mode of action for Alzheimer’s Disease”, XX Encontro Luso -Galego de Química, Porto, Portugal, 26-28 November, 2014, P-29, p. 361. Maria Inês S. Cruz*, Sara M. Cravo, Honorina Cidade, Madalena Pinto, “Xanthone Mannich base derivatives with potential dual mode of action for Alzheimer’s Disease”, III ENEQUI - 3º Encontro Nacional de Estudantes de Química, Aveiro, Portugal, 27-29 March, 2015. Maria Inês S. Cruz*, Sara M. Cravo, Honorina Cidade, Madalena Pinto, “Synthesis of xanthone derivatives with potential dual mode of action for Alzheimer’s Disease”, IJUP15 - 5th Meeting of Young Researchs of U.
    [Show full text]
  • Recent Progress in Biologically Active Xanthones
    Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2016, 8(1):75-131 ISSN : 0975-7384 Review Article CODEN(USA) : JCPRC5 Recent progress in biologically active xanthones a b a a Arshdeep Singh , Navdeep Kaur , Sahil Sharma * and Preet Mohinder Singh Bedi aDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India bDepartment of Chemistry, Guru Nanak Dev University, Amritsar, Punjab, India _____________________________________________________________________________________________ ABSTRACT Xanthone is a novel and pharmacologically important oxygen containing hetrocyclic ring exhibiting variety of potent biological activities. This fused tricyclic ring is derived naturally from the plants of Bonnetiaceae and Clusiaceae family as well as synthesized by employing various synthetic protocols. Their wide range of reported therapeutic attributes include α-glucosidase inhibition, anti-cancer, anti-oxidant, anti-asthmatic, anti-convulsant, xanthine oxidase inhibition and anti-microbial. Among these attributes, anti-cancer and anti-oxidant potential are comprehensively studied as evidenced by number of research papers. Although, there is no marketed formulation containing xanthone derivatives except some herbal formulations, their medicinal properties can not be neglected at all. Promising activities revealed by these compounds chains their use and places them ahead as potential drug candidates for the future studies. Therefore, the present review article is entirely an assemblage of
    [Show full text]