sign in sign up
<<
Home , Acotiamide, Corydaline, Corynoline, Demecarium bromide, Xanthone

AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter . AChE is found at mainly neuromuscular junctions and brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

www.MedChemExpress.com 1 AChE Inhibitors & Activators

(+)- (-)-Corynoxidine Cat. No.: HY-16009 Cat. No.: HY-N7010

(+)-Phenserine is a novel selective (-)-Corynoxidine is an acetylcholinesterase

noncompetitive inhibitor with an IC50 of 45.3 μM. inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. Purity: 98.09% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 1 mg, 5 mg

(-)- (R)- D6 tartrate (Huperzine A) Cat. No.: HY-17387 Cat. No.: HY-11017AS

(-)-Huperzine A (Huperzine A) is an (R)-Rivastigmine D6 tartrate is the deuterium isolated from a Chinese club moss, with labeled (R)-Rivastigmine, which is an neuroprotective activity. cholinesterase inhibitor.

Purity: ≥98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 200 mg Size: 1 mg, 5 mg

(±)-Huperzine A 1-Naphthyl acetate Cat. No.: HY-17388 Cat. No.: HY-W016188

(±)-Huperzine A, an active Lycopodium alkaloid 1-Naphthyl acetate is an attractive chromogenic extracted from traditional Chinese herb, is a substrate for the detection of erythrocyte potent, selective and reversible acetylcholinesterase (AChE) activity. 1-Naphthyl acetylcholinesterase (AChE) inhibitor and has been acetate has the potential to detect widely used in China for the treatment of organophosphorus pesticide (OP) poisoning. Alzheimer's disease (AD). Purity: ≥98.0% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 500 mg

4-Methylbenzylidene camphor (4-MBC; Enzacamene) Cat. No.: HY-17587 Cat. No.: HY-B0841

4-Methylbenzylidene camphor(4-MBC; Enzacamene)is Acephate is an anticholinesterase insecticide that an organic camphor derivative that is used in the produces cholinotoxicity. Acephate displays weak cosmetic industry for its ability to protect the inhibition of rat AChE but potently inhibits skin against UV, specifically UV B radiation. cockroach AChE.

Purity: 99.86% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 50 mg, 100 mg

Acetylshikonin AChE/BChE-IN-1 Cat. No.: HY-N2181 Cat. No.: HY-131971

Acetylshikonin, derived from the root of AChE/BChE-IN-1 is a potent and brain-penetrant Lithospermum erythrorhizon, has anti-cancer and dual inhibitor of Acetylcholinesterase and

antiinflammation activity. Acetylshikonin is a , with IC50s of 1.06 and 7.3 non-selective cytochrome P450 inhibitor nM for hAChE and hBChE, respectively.

against all P450s (IC50 values range from 1.4-4.0 AChE/BChE-IN-1 also has antioxidant activity. μM). Purity: 98.06% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg

2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Acotiamide monohydrochloride trihydrate Ajmalicine Cat. No.: HY-B2155 (Raubasine) Cat. No.: HY-N1919

Acotiamide monohydrochloride trihydrate is an Ajmalicine (Raubasine) is found in herbs of orally active and first-in-class gastroprokinetic Catharanthus roseus, is an antihypertensive drug agent for the treatment of functional dyspepsia. used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure.

Purity: 99.28% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 1 mg, 5 mg

Aldicarb sulfone Cat. No.: HY-17530 Cat. No.: HY-114899

Aldicarb sulfone(Temik sulfone) is a Azamethiphos is an organophosphate insecticide and insecticide; is a cholinesterase inhibitor which a neurotoxic agent, causing acetylcholinesterase prevents the breakdown of acetylcholine in the (AChE) inhibition. synapse.

Purity: 99.24% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 1 mg, 5 mg

Benactyzine hydrochloride BuChE-IN-TM-10 Cat. No.: HY-B1542A (TM-10) Cat. No.: HY-114320

Benactyzine hydrochloride is a BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BChE) inhibitor with a Ki butyrylcholinesterase (BuChE) inhibitor, with an of 0.010 mM. IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Purity: 99.69% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 1 mg, 5 mg

Chlorpyrifos -oxon Cat. No.: HY-B0815 Cat. No.: HY-136610

Chlorpyrifos is an organophosphate insecticide Chlorpyrifos-oxon, an active metabolite of that is classified as a phosphorothionate. The Chlorpyrifos, is a potent phosphorylating agent oxon metabolite of Chlorpyrifos is an inhibitor of that potently inhibits AChE. Chlorpyrifos-oxon acetylcholinesterase (AChE), affecting can induce cross-linking between subunits of neurological function in insects, humans, and tubulin and disrupt microtubule function. other animals. Purity: ≥98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 50 mg, 100 mg Size: 1 mg, 5 mg

Corydaline ((+)-; Corydalin) Cat. No.: HY-N0923 Cat. No.: HY-N0826

Corydaline ((+)-Corydaline), an isoquinoline Corynoline, isolated from Corydalis incise alkaloid isolated from Corydalis yanhusuo, is an (Papaveraceae), is a reversible and noncompetitive

AChE inhibitor with an IC50 of 226 µM. Corydaline acetylcholinesterase (AChE) inhibitor with an is a μ-opioid receptor (Ki of 1.23 µM) agonist and IC50 of 30.6 μM. Corynoline exhibits inhibits enterovirus 71 (EV71) replication (IC50 anti-inflammatory activity by activating Nrf2. of 25.23 µM). Purity: 96.17% Purity: 98.06% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 20 mg

www.MedChemExpress.com 3

Coumaran Cyanidin-3-O-galactoside chloride (2,3-Dihydrobenzofuran) Cat. No.: HY-75247 (Ideain chloride) Cat. No.: HY-N4142

Coumaran (2,3-Dihydrobenzofuran) is an Cyanidin-3-O-galactoside chloride (Ideain acetylcholinesterase (AChE) inhibitor isolated chloride) is a component from extract peel of from leaves of L. camara. Coumaran can be used hawthorn fruit (EPHF) with the value of 179.4 as a biopesticide. mg/g. EPHF exhibits strong AChE inhibitory activity.

Purity: 99.69% Purity: 99.20% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg Size: 1 mg, 5 mg

Dehydronuciferine Cat. No.: HY-N4261 (BC-48) Cat. No.: HY-B1626A

Dehydronuciferine is isolated from the leaves of Demecarium Bromide (BC-48) is a potent Nelumbo nucifera Gaertn, a acetylcholinesterase cholinesterase inhibitor, with an apparent affinity

(AChE) inhibitor with an IC50 of 25 μg/mL. (Kiapp) of 0.15 μM. Demecarium Bromide (BC-48) is used as a agent.

Purity: ≥99.0% Purity: ≥95.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg

Dihydro Dihydrowithaferin A (Dihydro E2020) Cat. No.: HY-131252 (2,3-Dihydrowithaferin A) Cat. No.: HY-N5120

Dihydro Donepezil (Dihydro E2020) is a metabolite Dihydrowithaferin A (2, 3-dihydrowithaferin A) is of Donepezil. Donepezil is a specific and potent a withanolide isolated from Withania

AChE inhibitor with IC50s of 8.12 nM and 11.6 nM somnifera. Dihydrowithaferin A is active for bAChE and hAChE, respectively. against acetylcholinesterase (AChE).

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 1 mg, 5 mg

Donepezil Donepezil Hydrochloride (E2020 free base) Cat. No.: HY-14566 (E2020) Cat. No.: HY-B0034

Donepezil (E2020 free base) is a specific and Donepezil (Hydrochloride) (E-2020) is a

potent AChE inhibitor with IC50s of 8.12 nM and noncompetitive acetylcholinesterase inhibitor, 11.6 nM for bovine AChE and human AChE, which can readily cross the blood brain barrier respectively. and increases the concentration of cortical acetylcholine.

Purity: 99.96% Purity: 99.97% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg

Drofenine hydrochloride Ebeiedinone (Hexahydroadiphenine hydrochloride) Cat. No.: HY-B1239 Cat. No.: HY-107275

Drofenine hydrochloride is a potent competitive Ebeiedinone, a steroidal alkaloid from Fritillaria inhibitor of BChE, and the ki values of Drofenine species, inhibits the bioactivity of human whole is calculated to be 3 uM. IC50 value: 3 uM (ki) blood cholinesterase (ChE) at the concentration Target: BChE Benactyzine is widely used of 0.1 mM, with the inhibitory effects of 69.0%. drugs, acts on smooth muscle to stop muscle spasms. Purity: 98.10% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg Size: 1 mg, 5 mg

4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Edrophonium chloride Epi-galantamine Cat. No.: HY-B0882 Cat. No.: HY-N7265

Edrophonium chloride is a readily reversible Epi- is a diastereomer of Galantamine. acetylcholinesterase inhibitor; prevents breakdown Epi-galantamine is an alkaloid isolated from the of the neurotransmitter acetylcholine and acts by bulbs and flowers of Caucasian snowdrop (Galanthus competitively inhibiting the enzyme woronowii). Epi-galantamine inhibits AChE with acetylcholinesterase, mainly at the neuromuscular an EC50 of 45.7 μM. junction. Purity: 99.49% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 1 mg, 5 mg

Epiberberine Epiberberine chloride Cat. No.: HY-N0226 Cat. No.: HY-N0226A

Epiberberine is an alkaloid isolated from Coptis Epiberberine chloride is an alkaloid isolated from chinensis, acts as a potent AChE and BChE Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. respectively.

Purity: 98.46% Purity: 98.89% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg

Fenchlorphos Cat. No.: HY-B1093 Cat. No.: HY-B1885

Fenchlorphos, an organophosphate, is an Fenitrothion, one of the most widely used insecticide. Fenchlorphos is an inhibitor of the organophosphorus pesticides, is a cholinesterase enzyme acetylcholinesterase (AChE). Fenchlorphos inhibiting insecticide/acaricid. Fenitrothion is is able to cause mitochondrial dysfunction. widely used, as a broad-spectrum insecticide, on cotton crops, vegetables crops, fruit crops, and field crops especially paddy. Purity: 99.89% Purity: ≥97.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 50 mg, 100 mg Size: 10 mM × 1 mL, 100 mg, 250 mg

Galanthamine Galanthamine hydrobromide (Galantamine) Cat. No.: HY-76299 (Galantamine hydrobromide) Cat. No.: HY-A0009

Galanthamine is a potent acetylcholinesterase Galanthamine hydrobromide (Galantamine

(AChE) inhibitor with an IC50 of 500 nM. hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an

IC50 of 0.35 µM.

Purity: 99.90% Purity: 99.93% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg, 100 mg Size: 10 mM × 1 mL, 50 mg, 100 mg

Galanthamine N-Oxide Galanthaminone Cat. No.: HY-N7263 ((-)-Narwedine; Narwedin) Cat. No.: HY-I0020

Galanthamine N-Oxide is an alkaloid obtained from Galanthaminone (Narwedin) is a competitive and the bulbs of Zephyranthes concolor. Galanthamine reversible cholinesterase (AChE) inhibitor; is N-Oxide inhibits electric eel acetylcholinesterase used for the treatment of mild to moderate

(AChE) with an EC50 of 26.2 μM. Alzheimer's disease and various other memory impairments.

Purity: >98% Purity: 99.55% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg

www.MedChemExpress.com 5

Garcinol Huperzine B Cat. No.: HY-107569 Cat. No.: HY-N2043

Garcinol, a polyisoprenylated benzophenone Huperzine B is a Lycopodium alkaloid isolated harvested from Garcinia indica, exerts from Huperzia serrata and a highly selective anti-cholinesterase properties towards acetyl acetylcholinesterase (AChE) inhibitor. Huperzine B cholinesterase (AChE) and butyrylcholinesterase can be uesd to can be used to improve Alzheimer's

(BChE) with IC50s of 0.66 µM and 7.39 µM, disease. respectively. Purity: ≥98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 1 mg, 5 mg Size: 5 mg, 10 mg, 20 mg

Huperzine C Imperatorin Cat. No.: HY-122957 (Ammidin) Cat. No.: HY-N0285

Huperzine C is an alkaloid isolated from Huperzia Imperatorin is an effective of NO synthesis

serrate. Huperzine C is an acetylcholinesterase inhibitor (IC50=9.2 μmol), which also is a BChE

(AChE) inhibotor, with an IC50 of 0.6 μM. inhibitor (IC50=31.4 μmol). Imperatorin is a weak

Huperzine C can be used for the research of agonist of TRPV1 with EC50 of 12.6±3.2 μM. Alzheimer’s disease.

Purity: >98% Purity: 95.81% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg

Isoeugenol acetate Isoimperatorin (Acetyl isoeugenol) Cat. No.: HY-N6805 Cat. No.: HY-N0286

Isoeugenol acetate (Acetyl isoeugenol), an Isoimperatorin is a methanolic extract of the essential oil constituent of nutmeg, clove, and roots of Angelica dahurica shows significant cinnamon, shows excellent inhibitory effects inhibitory effects on acetylcholinesterase (AChE)

against some metabolic enzymes such as with the IC50 of 74.6 μM.

acetylcholinesterase (AChE) enzymes (IC50=77 nM;

Ki=16 nM), α-glycosidase (IC50=19.25 nM;… Purity: >98% Purity: 99.09% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 5 mg, 10 mg, 25 mg

Isomerazin Isoprocarb Cat. No.: HY-N3468 Cat. No.: HY-B0830

Isomerazin is a coumarin isolated from Poncirus Isoprocarb is carbamate insecticide that widely trifoliate Raf., and shows cholinesterase used to control rice paddy lice and leafhopper. inhibition. Isoprocarb is also an AChE inhibitor.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 1 mg, 5 mg

Isorosmanol hydrochloride Cat. No.: HY-N4191 (HSR803) Cat. No.: HY-B0732

Isorosmanol is an abietane-type diterpene isolated Itopride hydrochloride (HSR803), a from the leaves of sage, with antioxidant, gastroprokinetic Benzamide (HY-Z0283) derivative, neuroprotective and neurotrophic effects. is an inhibitor of acetylcholinesterase (AChE) and Isorosmanol inhibits AChE activity and melanin dopamine D2 receptor. synthesis.

Purity: >98% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 500 mg, 1 g, 5 g

6 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Jatrorrhizine Jatrorrhizine chloride Cat. No.: HY-N0749 Cat. No.: HY-N0740

Jatrorrhizine is an alkaloid isolated Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant antimicrobial, antiplasmodial and antioxidant activities. activities.

Purity: >98% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 20 mg

Jatrorrhizine hydroxide Cat. No.: HY-N0749A (TV-3326) Cat. No.: HY-10399

Jatrorrhizine hydroxide is an alkaloid isolated Ladostigil (TV-3326) is a dual inhibitor of from Coptis chinensis with neuroprotective, cholinesterase and brain-selective monoamine antimicrobial, antiplasmodial and antioxidant oxidase (MAO), with an IC50 of 37.1 and 31.8 μM activities. for MAO-B and AChE, reapectively.

Purity: 98.02% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 1 mg, 5 mg

Leptomerine Linarin Cat. No.: HY-N4206 (Buddleoside; Linarine) Cat. No.: HY-N0528

Leptomerine, an alkaloid from stems of Esenbeckia Linarin (Buddleoside), isolated from the flower leiocarpa Engl. (Rutaceae) as potential treatment extract of Mentha arvensis, shows selective dose for Alzheimer Disease. Leptomerine inhibits acetyl dependent inhibitory effect on cholinesterase (AChE) with an IC50 of 2.5 μM. acetylcholinesterase (AChE). Anticholinesterasic activity.

Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 5 mg, 10 mg, 20 mg

Lycoramine Lycoramine hydrobromide Cat. No.: HY-N6619A Cat. No.: HY-N6619

Lycoramine, a dihydro-derivative of galanthamine, Lycoramine hydrobromide, a dihydro-derivative of is isolated from Lycoris radiate. Lycoramine is a galanthamine, is isolated from Lycoris radiate. potent acetylcholinesterase (AChE) inhibitor. Lycoramine hydrobromide is a potent acetylcholinesterase (AChE) inhibitor.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg

MHP 133 N-p-trans-Coumaroyltyramine Cat. No.: HY-101653 Cat. No.: HY-N2230

MHP 133 is a drug with multiple CNS targets, and N-p-trans-Coumaroyltyramine is a inhibits acetylcholinesterase (AChE) with Ki of 69 cinnamoylphenethyl amide isolated from μM; also active against muscarinic M1 and M2 polygonum hyrcanicum, acts as an receptors, serotonin 5HT4 receptors, and imidazole acetylcholinesterase (AChE) inhibitor with an an

I2 receptors. IC50 of 122 μM.

Purity: >98% Purity: 98.78% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg, 10 mg

www.MedChemExpress.com 7

Neoeriocitrin methyl sulfate Cat. No.: HY-N4119 Cat. No.: HY-B1206

Neoeriocitrin, isolated from Drynaria Neostigmine methyl sulfate is a reversible Rhizome, shows activity on proliferation and inhibitor of acetylcholinesterase, can not cross osteogenic differentiation in MC3T3-E1. the blood-brain barrier. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.

Purity: >98% Purity: 99.71% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg

Nodakenin O-Desmethyl Galanthamine Cat. No.: HY-N0825 (Sanguinine) Cat. No.: HY-131413

Nodakenin is a major coumarin glucoside in the O-Desmethyl Galanthamine (Sanguinine) is root of Peucedanum decursivum Maxim. galanthamine-type alkaloid. O-Desmethyl Nodakenin inhibits acetylcholinesterase (AChE) Galanthamine is an acetylcholinesterase (AChE)

activity with an IC50 of 84.7 μM. inhibitor, with an IC50 1.83 μM.

Purity: >98% Purity: 95.08% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg

Obidoxime dichloride P11149 Cat. No.: HY-W011108 Cat. No.: HY-105327

Obidoxime dichloride is a non-full spectrum oxime P11149 is a competitive, BBB-penetarated weakly, agent and can be used as an antidote for orally active and selective inhibitor of AChE.

organophosphate poisoning. Obidoxime P11149 exhibits an IC50 of 1.3 μM for rat dichloride reactivates -inhibited BChE/AChE. P11149, a Galanthamine derivative, acetylcholinesterase (AChE) and reduces acute demonstrates central cholinergic activity, toxicity of sarin-evaluated. behavioral efficacy and safety. Purity: >98% Purity: 99.23% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg, 10 mg

PCS1055 dihydrochloride Penconazole Cat. No.: HY-122203 Cat. No.: HY-135761

PCS1055 dihydrochloride is a potent, selective and Penconazole is a typical triazole fungicide, and competitive muscarinic M4 receptor antagonist mainly applied on apples, grapes, and vegetables

with an IC50 of 18.1 nM and a Kd of 5.72 nM. to control powdery mildew. Penconazole inhibits PCS1055 dihydrochloride inhibits radioligand sterol biosynthesis in fungi. Penconazole decrease [3H]-NMS binding to the M4 receptor with a AChE activity in the cerebrum and cerebellum of

Ki of 6.5 nM. rats. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 250 mg

Phenserine ((-)-Eseroline phenylcarbamate; (-)-Phenserine) Cat. No.: HY-103374 Cat. No.: HY-118165

Phenserine ((-)-Eseroline phenylcarbamate) is a Phenthoate is an organophosphorus pesticide having derivative of and is a potent, low toxicity in animals. Phenthoate is also a noncompetitive, long-acting and selective AChE AChE inhibitor. inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Purity: ≥99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 1 mg, 5 mg

8 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Physostigmine Physostigmine hemisulfate (Eserine) Cat. No.: HY-N6608 (Eserine hemisulfate) Cat. No.: HY-N2320

Physostigmine (Eserine) is a reversible Physostigmine hemisulfate (Eserine hemisulfate) is acetylcholinesterase (AChE) inhibitor. a reversible acetylcholinesterase (AChE) Physostigmine can crosses the blood-brain barrier inhibitor. Physostigmine hemisulfate can crosses and stimulates central cholinergic the blood-brain barrier and stimulates central neurotransmission. cholinergic neurotransmission.

Purity: >98% Purity: >98% Clinical Data: Phase 4 Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Physostigmine salicylate Picfeltarraegenin X (Eserine salicylate) Cat. No.: HY-B1266 Cat. No.: HY-N2219

Physostigmine salicylate (Eserine salicylate) is a Picfeltarraenin X, a triterpenoid isolated from reversible acetylcholinesterase (AChE) inhibitor. Picria fel-terrae Lour, is an AChE inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission.

Purity: ≥99.00% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Picfeltarraenin IA Picfeltarraenin IB Cat. No.: HY-N1474 Cat. No.: HY-N2211

Picfeltarraenin IA, a triterpenoid obtained from Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation. of herpes infections, cancer and inflammation.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 20 mg

Picfeltarraenin IV Cat. No.: HY-N5076 Cat. No.: HY-119419

Picfeltarraenin IV, a triterpenoid obtained from Pirimicarb is a fast-acting selective carbamate Picriafel-terrae Lour (P.fel-terrae), is an insecticide on a wide range of crops including acetylcholinesterase (AChE) inhibitor. cereals, sugar beet, potatoes, fruits and Picfeltarraenin IV can be used for the treatment vegetables. Pirimicarb is an AChE inhibitor and of herpes infections, cancer and inflammation. an acaricide.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Pirimiphos-methyl Pitofenone hydrochloride Cat. No.: HY-B1881 Cat. No.: HY-110389

Pirimiphos-methyl is a rapid-acting Pitofenone hydrochloride, a spasmolytic compound, organophosphorus insecticide and acaricide, inhibits the acetylcholinesterase (AChE) activity causing inhibition of AChE in target organisms. from bovine erythrocytes and from electric eel

with Kis of 36 and 45 μM, respectively.

Purity: 98.22% Purity: 99.88% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 250 mg, 500 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 9

Polygalacic acid chloride Cat. No.: HY-N0801 (2-PAM chloride) Cat. No.: HY-B1200

Polygalacic acid, is a triterpene, isolated from Pralidoxime chloride is a useful agent in the the root of Polygala tenuifolia Willd. treatment of organophosphate poisoning. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment .

Purity: 98.92% Purity: 99.24% Clinical Data: Phase 3 Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg

Pralidoxime iodide Cat. No.: HY-B1738A Cat. No.: HY-B0832

Pralidoxime iodide is a reactivator of Profenofos is an insecticida used on field crops, acetylcholinesterase (AChE). Pralidoxime iodide vegetables, and fruit crops. Profenofos is an reactivates nerve agent, which inhibits AChE via acetylcholinesterase (AChE) inhibitor, with direct nucleophilic attack by the oxime moiety on neurotoxicity. the phosphorus center of the bound nerve agent.

Purity: ≥98.0% Purity: 95.92% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 25 mg, 100 mg, 250 mg Size: 10 mM × 1 mL, 250 mg

Protriptyline hydrochloride Pseudocoptisine acetate Cat. No.: HY-B0949 (Isocoptisine acetate) Cat. No.: HY-N6894

Protriptyline hydrochloride is a tricyclic Pseudocoptisine (Isocoptisine) acetate is a antidepressant (TCA), specifically a secondary quaternary alkaloid with benzylisoquinoline amine, for the treatment of depression and ADHD. skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits

acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Purity: 99.91% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg Size: 1 mg, 5 mg

Pseudocoptisine chloride Pteryxin (Isocoptisine chloride) Cat. No.: HY-N6894A ((+)-Pteryxin) Cat. No.: HY-N2157

Pseudocoptisine (Isocoptisine) chloride is a Pteryxin, a coumarin in Peucedanum japonicum quaternary alkaloid with benzylisoquinoline Thunb leaves, exerts antiobesity activity. Pteryxin skeleton, was isolated from Corydalis Tuber. is a potent butyrylcholinesterase (BChE)

Pseudocoptisine chloride inhibits inhibitor, with an IC50 of 12.96 μg/ml.

acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Purity: 99.17% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 5 mg, 10 mg, 20 mg

Pyridostigmine bromide D6 bromide Cat. No.: HY-B0207A Cat. No.: HY-B0207AS

Pyridostigmine bromide is a parasympathomimetic Pyridostigmine D6 bromide is the deuterium labeled and a reversible cholinesterase inhibitor. Target: Pyridostigmine, which is a parasympathomimetic and AChE Pyridostigmine bromide is a a reversible cholinesterase inhibitor. parasympathomimetic and a reversible cholinesterase inhibitor.

Purity: ≥98.0% Purity: 99.17% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg

10 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Rhodionin Rhodiosin Cat. No.: HY-N0241 Cat. No.: HY-N2425

Rhodionin, isolated from the root of Rhodiola Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome crenulata, is a specific non-competitive cytochrome

P450 2D6 inhibitor with an IC50 of 0.761 μM and a P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.769 μM. Ki of 0.535 μM.

Purity: 98.78% Purity: 99.07% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 20 mg

Rivastigmine Rivastigmine carbamate impurity (S-Rivastigmine) Cat. No.: HY-17368 (3-Nitrophenyl ethyl(methyl)carbamate) Cat. No.: HY-133776

Rivastigmine (S-Rivastigmine) is an orally active Rivastigmine carbamate impurity (3-Nitrophenyl and potent cholinesterase (ChE) inhibitor and ethyl(methyl)carbamate) is an impurity of inhibits butyrylcholinesterase (BChE) and Rivastigmine. acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Purity: 98.75% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg Size: 1 mg, 5 mg

Rivastigmine tartrate RPR121056 (ENA 713; SDZ-ENA 713) Cat. No.: HY-11017 (APC) Cat. No.: HY-100620

Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an RPR121056 (APC) is a metabolite of Irinotecan orally active and potent cholinesterase (ChE) (CPT-11), which is generated by CYP3A4. Irinotecan inhibitor and inhibits butyrylcholinesterase (CPT-11) is an antineoplastic agent that inhibits

(BChE) and acetylcholinesteras (AChE) with IC50s topoisomerase type I, causing cell death, and is of 0.037 μM, 4.15 μM, respectively. widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE. Purity: 99.45% Purity: >98% Clinical Data: Launched Clinical Data: Phase 3 Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg Size: 1 mg, 5 mg

RX 67668 Scopoletin Cat. No.: HY-124047 (Gelseminic acid; Chrysatropic acid) Cat. No.: HY-N0342

RX 67668 is a potent cholinesterase inhibitor with Scopoletin is an inhibitor of acetylcholinesterase an IC50 of 5 μM for both acetylcholinesterase (AChE). (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue. Purity: >98% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 50 mg, 100 mg, 200 mg

Sinapine Sinapine hydroxide Cat. No.: HY-N5077 Cat. No.: HY-N5077B

Sinapine is an alkaloid isolated from seeds of the Sinapine hydroxide is an alkaloid isolated from cruciferous species. Sinapine exhibits seeds of the cruciferous species. Sinapine anti-inflammatory, anti-oxidant, anti-tumor, hydroxide exhibits anti-inflammatory, anti-angiogenic and radio-protective effects. anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects.

Purity: 99.87% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 11

Sinapine thiocyanate sn-Glycero-3-phosphocholine Cat. No.: HY-N0450 (Choline Alfoscerate; Alpha-GPC; L-α-GPC) Cat. No.: HY-17552

Sinapine thiocyanate is an alkaloid isolated from sn-Glycero-3-phosphocholine (Choline Alfoscerate) seeds of the cruciferous species. Sinapine is a precursor in the biosynthesis of brain thiocyanate exhibits anti-inflammatory, phospholipids and increases the bioavailability of anti-oxidant, anti-tumor, anti-angiogenic and choline in nervous tissue. radio-protective effects.

Purity: 98.32% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g, 10 g

Sophoflavescenol Swertianolin Cat. No.: HY-N2284 Cat. No.: HY-N2192

Sophoflavescenol is a prenylated flavonol, which Swertianolin, a xanthone isolated from Gentianella

shows great inhibitory activity with IC50 of 0.013 Acuta, inhibits acetylcholinesterase (AChE). μM against Phosphodiesterase 5 (PDE5), and also Swertianolin also exhibits anti-HBV and inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE anti-bacterial activity.

with IC50s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively. Purity: 98.15% Purity: 99.54% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

T 82 hydrochloride Cat. No.: HY-U00028 Cat. No.: HY-B1488

T 82 is a potent 5-HT3 antagonist and Tacrine hydrochloride is a potent inhibitor of

acetylcholinesterase (AChE) inhibitor, used for both AChE and BChE, with IC50s of 31 nM and 25.6 treatment of Alzheimer's Disease. nM, respectively. Tacrine hydrochloride is also a

NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease. Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg

Tacrine hydrochloride (hydrate) Tenuifolin Cat. No.: HY-B2244 Cat. No.: HY-N0702

Tacrine hydrochloride (hydrate) is an inhibitor of Tenuifolin is a triterpene isolated from Polygala both acetyl (AChE) and butyryl-cholinestrase tenuifolia Willd, has neuroprotective

(BChE) with IC50s of 31 nM and 25.6 nM, effects. Tenuifolin reduces Aβ secretion by respectively. inhibiting β-secretase.

Purity: 99.98% Purity: ≥98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 5 mg, 10 mg, 20 mg

Timosaponin AIII Trimyristin Cat. No.: HY-N0810 Cat. No.: HY-N2511

Timosaponin AIII could inhibit Trimyristin, an active molluscicidal component acetylcholinesterase (AChE) activity, with an of Myristica fragrans Houtt,

IC50 of 35.4 μM. significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. Purity: 98.88% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg Size: 5 mg, 10 mg, 20 mg

12 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Vincosamide Violanthin Cat. No.: HY-N1089 Cat. No.: HY-N6895

Vincosamide, an alkaloid from Psychotria leiocarpa Violanthin is isolated from the aerial parts of extract, inhibits the acetylcholinesterase (AChE) Piper bavinum, has potent antioxidant and activity with anti-inflammatory activity. antibacterial activities. Violanthin inhibits

acetylcholinesterase (AChE) with an IC50 value of 79.80 μM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Size: 1 mg, 5 mg Size: 5 mg, 10 mg

Vomifoliol α-NETA Cat. No.: HY-N1077 Cat. No.: HY-138097

Vomifoliol, a compound related to abscisie acid α-NETA is a potent and noncompetitive choline

(ABA), has a modified 2,4-pentadiene side chain acetyltransferase (ChA) inhibitor with an IC50 of and has activity equal to that displayed by ABA. 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) Vomifoliol exhibits antiacetylcholinesterase and chemokine-like receptor-1 (CMKLR1) activity and displays moderate antileishmanial antagonist. activity. Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

β-NETA Cat. No.: HY-124957

β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC50=76 μM) and cholinesterase (ChE; IC50=40 µM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; IC50=1 mM).

Purity: ≥98.0% Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 13