List of Extremely Hazardous Substances
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COMBINED LIST of Particularly Hazardous Substances
COMBINED LIST of Particularly Hazardous Substances revised 2/4/2021 IARC list 1 are Carcinogenic to humans list compiled by Hector Acuna, UCSB IARC list Group 2A Probably carcinogenic to humans IARC list Group 2B Possibly carcinogenic to humans If any of the chemicals listed below are used in your research then complete a Standard Operating Procedure (SOP) for the product as described in the Chemical Hygiene Plan. Prop 65 known to cause cancer or reproductive toxicity Material(s) not on the list does not preclude one from completing an SOP. Other extremely toxic chemicals KNOWN Carcinogens from National Toxicology Program (NTP) or other high hazards will require the development of an SOP. Red= added in 2020 or status change Reasonably Anticipated NTP EPA Haz list COMBINED LIST of Particularly Hazardous Substances CAS Source from where the material is listed. 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide Acutely Toxic Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- Acutely Toxic 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) Prop 65 KNOWN Carcinogens NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) IARC list Group 2A Reasonably Anticipated NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Prop 65 1-(o-Chlorophenyl)thiourea Acutely Toxic 1,1,1,2-Tetrachloroethane IARC list Group 2B 1,1,2,2-Tetrachloroethane Prop 65 IARC list Group 2B 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) Prop 65 1,1-Dichloroethane -
Chemical Hygiene Plan Manual
CHEMICAL HYGIENE PLAN AND HAZARDOUS MATERIALS SAFETY MANUAL FOR LABORATORIES This is the Chemical Hygiene Plan specific to the following areas: Laboratory name or room number(s): ___________________________________ Building: __________________________________________________________ Supervisor: _______________________________________________________ Department: _______________________________________________________ Telephone numbers 911 for Emergency and urgent consultation 48221 Police business line 46919 Fire Dept business line 46371 Radiological and Environmental Management Revisied on: Enter a revision date here. All laboratory chemical use areas must maintain a work-area specific Chemical Hygiene Plan which conforms to the requirements of the OSHA Laboraotry Standard 29 CFR 19190.1450. Purdue University laboratories may use this document as a starting point for creating their work area specific CHP. Minimally this cover page is to be edited for work area specificity (non-West Lafayette laboratories are to place their own emergency, fire, and police telephone numbers in the space above) AND appendix K must be completed. This instruction and information box should remain. This model CHP is version 2010A; updates are to be found at www.purdue.edu/rem This page intentionally blank. PURDUE CHEMICAL HYGIENE PLAN AWARENESS CERTIFICATION For CHP of: ______________________________ Professor, building, rooms The Occupational Safety and Health Administration (OSHA) requires that laboratory employees be made aware of the Chemical Hygiene Plan at their place of employment (29 CFR 1910.1450). The Purdue University Chemical Hygiene Plan and Hazardous Materials Safety Manual serves as the written Chemical Hygiene Plan (CHP) for laboratories using chemicals at Purdue University. The CHP is a regular, continuing effort, not a standby or short term activity. Departments, divisions, sections, or other work units engaged in laboratory work whose hazards are not sufficiently covered in this written manual must customize it by adding their own sections as appropriate (e.g. -
Biochemical and Pathological Effects of Methylazoxymethanol Acetate, a Potent Carcinogen1
[CANCER RESEARCH 30, 801-812, March 1970] Biochemical and Pathological Effects of Methylazoxymethanol Acetate, a Potent Carcinogen1 Morris S. Zedeck, Stephen S. Sternberg, Richard W. Poynter, and Jane McGowan Divisions of Pharmacology and Cytology, Sloan-Kettering Institute for Cancer Research, New York, New York 10021 SUMMARY vealed that the agent is cleaved by the intestinal flora which possess a 0-o-glucosidase, and that the free agly Methylazoxymethanol acetate is known to induce tu cone methylazoxymethanol is the active carcinogen (13- mors in rodents. Effects produced by a single nonlethal 15, 34). Matsumoto et al. (19) synthesized MAM acetate3 dose on nucleic acid and protein synthesis have been in (Chart 1), which is stable and not dependent upon vestigated in rat and mouse liver, small intestine, and ,0-glucosidase cleavage for activity. Single or only a few kidney, the 3 organs most susceptible to carcinogenesis. doses of cycasin, or of the aglycone methylazoxymetha The agent induced early inhibition of thymidine incor nol, are required to induce tumors in rats which are pri poration into DNA of rat tissues. Rat liver was most sen marily of the kidney, intestinal tract, and liver (11, 15). sitive to this effect and was the only organ to show marked Aqueous extracts of cycad nut have also been shown to inhibition of RNA and protein synthesis. In mice, liver induce tumors of liver and kidneys in mice (21). The was more sensitive than small intestine or kidney and ex present investigation was undertaken to study the acute hibited an inhibition of RNA and protein synthesis; there pathological and biochemical effects produced by MAM were no changes observed in small intestine or kidney. -
Benzene MSDS
He a lt h 2 3 Fire 3 2 0 Re a c t iv it y 0 Pe rs o n a l Pro t e c t io n H Material Safety Data Sheet Benzene MSDS Section 1: Chemical Product and Company Identification Product Name: Benzene Contact Information: Catalog Codes: SLB1564, SLB3055, SLB2881 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 71-43-2 Houston, Texas 77396 RTECS: CY1400000 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Benzene Order Online: ScienceLab.com CI#: Not available. CHEMTREC (24HR Emergency Telephone), call: Synonym: Benzol; Benzine 1-800-424-9300 Chemical Name: Benzene International CHEMTREC, call: 1-703-527-3887 Chemical Formula: C6-H6 For non-emergency assistance, call: 1-281-441-4400 Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Benzene 71-43-2 100 Toxicological Data on Ingredients: Benzene: ORAL (LD50): Acute: 930 mg/kg [Rat]. 4700 mg/kg [Mouse]. DERMAL (LD50): Acute: >9400 mg/kg [Rabbit]. VAPOR (LC50): Acute: 10000 ppm 7 hours [Rat]. Section 3: Hazards Identification Potential Acute Health Effects: Very hazardous in case of eye contact (irritant), of inhalation. Hazardous in case of skin contact (irritant, permeator), of ingestion. Inflammation of the eye is characterized by redness, watering, and itching. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Classified A1 (Confirmed for human.) by ACGIH, 1 (Proven for human.) by IARC. MUTAGENIC EFFECTS: Classified POSSIBLE for human. Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female [POSSIBLE]. -
Carbon Tetrachloride
CARBON TETRACHLORIDE Data were last reviewed in IARC (1979) and the compound was classified in IARC Monographs Supplement 7 (1987a). 1. Exposure Data 1.1 Chemical and physical data 1.1.1 Nomenclature Chem. Abstr. Serv. Reg. No.: 56-23-5 Chem. Abstr. Name: Tetrachloromethane IUPAC Systematic Name: Carbon tetrachloride Synonyms: Benzinoform; carbona 1.1.2 Structural and molecular formulae and relative molecular mass Cl Cl CCl Cl CCl4 Relative molecular mass: 153.82 1.1.3 Chemical and physical properties of the pure substance (a) Description: Colourless, clear, nonflammable, liquid with a characteristic odour (Budavari, 1996) (b) Boiling-point: 76.8°C (Lide, 1997) (c) Melting-point: –23°C (Lide, 1997) (d) Solubility: Very slightly soluble in water (0.05% by volume); miscible with benzene, chloroform, diethyl ether, carbon disulfide and ethanol (Budavari, 1996) (e) Vapour pressure: 12 kPa at 20°C; relative vapour density (air = 1), 5.3 at the boiling-point (American Conference of Governmental Industrial Hygienists, 1991) (f) Conversion factor: mg/m3 = 6.3 × ppm 1.2 Production and use Production in the United States in 1991 was reported to be approximately 143 thousand tonnes (United States International Trade Commission, 1993). Information –401– 402 IARC MONOGRAPHS VOLUME 71 available in 1995 indicated that carbon tetrachloride was produced in 24 countries (Che- mical Information Services, 1995). Carbon tetrachloride is used in the synthesis of chlorinated organic compounds, including chlorofluorocarbon refrigerants. It is also used as an agricultural fumigant and as a solvent in the production of semiconductors, in the processing of fats, oils and rubber and in laboratory applications (Lewis, 1993; Kauppinen et al., 1998). -
Arsenic Pentafluoride Sds- Material Safety Data Sheet
Tel: 514-956-7503 Fax: 514-956-7504 Internet: www.megs.ca E-mail: [email protected] Montreal St-Laurent Tel : 514-956-7503 Fax : 514-956-7504 Ottawa Nepean Tel : 613-226-4228 Fax : 613-226-4229 Quebec Quebec Tel : 418-834-7447 Fax : 418-834-3774 ARSENIC PENTAFLUORIDE SDS- MATERIAL SAFETY DATA SHEET TABLE OF CONTENTS: 1. Chemical Product and Company Identification 24 Hour EMERGENCY 2. Composition, Information on Ingredients CONTACT 3. Hazards Identification 4. First Aid Measures 5. Fire Fighting Measures U.S- CHEMTREC 1-800- 6. Accidental Release Measures 424-9300 7. Handling and Storage 8. Exposure Controls, Personal Protection CANADA- CANUTEC 613- 9. Physical and Chemical Properties 996-6666 10. Stability and Reactivity 11. Toxicological Information 12. Ecological Information 13. Disposal Considerations 14. Transport Information 15. Regulatory Information 16. Other Information 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION-----------Up to Table of Contents Matheson Tri-Gas, Inc. The telephone numbers listed below are emergency numbers, please contact your local branch for routine inquiries. USA CANADA 959 Route 46 East 530 Watson Street Parsippany, New Jersey Whitby, Ontario 07054-0624 USA L1N 5R9 Canada Phone: 973-257-1100 Phone: 905-668-3570 SUBSTANCE: ARSENIC PENTAFLUORIDE SDS SYMBOL: AsF5 TRADE NAMES/SYNONYMS: ARSORANE, PENTAFLUORO-; ARSENIC FLUORIDE (ASF5); ARSENIC FLUORIDE; ASF5; MAT02015 CHEMICAL FAMILY: non-metallic, halides CREATION DATE: Jan 24 1989 REVISION DATE: Mar 16 1999 2. COMPOSITION, INFORMATION ON INGREDIENTS-----------Up -
2019 Minnesota Chemicals of High Concern List
Minnesota Department of Health, Chemicals of High Concern List, 2019 Persistent, Bioaccumulative, Toxic (PBT) or very Persistent, very High Production CAS Bioaccumulative Use Example(s) and/or Volume (HPV) Number Chemical Name Health Endpoint(s) (vPvB) Source(s) Chemical Class Chemical1 Maine (CA Prop 65; IARC; IRIS; NTP Wood and textiles finishes, Cancer, Respiratory 11th ROC); WA Appen1; WA CHCC; disinfection, tissue 50-00-0 Formaldehyde x system, Eye irritant Minnesota HRV; Minnesota RAA preservative Gastrointestinal Minnesota HRL Contaminant 50-00-0 Formaldehyde (in water) system EU Category 1 Endocrine disruptor pesticide 50-29-3 DDT, technical, p,p'DDT Endocrine system Maine (CA Prop 65; IARC; IRIS; NTP PAH (chem-class) 11th ROC; OSPAR Chemicals of Concern; EuC Endocrine Disruptor Cancer, Endocrine Priority List; EPA Final PBT Rule for 50-32-8 Benzo(a)pyrene x x system TRI; EPA Priority PBT); Oregon P3 List; WA Appen1; Minnesota HRV WA Appen1; Minnesota HRL Dyes and diaminophenol mfg, wood preservation, 51-28-5 2,4-Dinitrophenol Eyes pesticide, pharmaceutical Maine (CA Prop 65; IARC; NTP 11th Preparation of amino resins, 51-79-6 Urethane (Ethyl carbamate) Cancer, Development ROC); WA Appen1 solubilizer, chemical intermediate Maine (CA Prop 65; IARC; IRIS; NTP Research; PAH (chem-class) 11th ROC; EPA Final PBT Rule for 53-70-3 Dibenzo(a,h)anthracene Cancer x TRI; WA PBT List; OSPAR Chemicals of Concern); WA Appen1; Oregon P3 List Maine (CA Prop 65; NTP 11th ROC); Research 53-96-3 2-Acetylaminofluorene Cancer WA Appen1 Maine (CA Prop 65; IARC; IRIS; NTP Lubricant, antioxidant, 55-18-5 N-Nitrosodiethylamine Cancer 11th ROC); WA Appen1 plastics stabilizer Maine (CA Prop 65; IRIS; NTP 11th Pesticide (EPA reg. -
Guidelines for the Preparation of Safety Data Sheets
GUIDELINES FOR THE PREPARATION OF SAFETY DATA SHEETS EIGA 919/14 Revision of EIGA 919/13 EUROPEAN INDUSTRIAL GASES ASSOCIATION AISBL AVENUE DES ARTS 3-5 • B – 1210 BRUSSELS Tel: +32 2 217 70 98 • Fax: +32 2 219 85 14 E-mail: [email protected] • Internet: www.eiga.eu EIGA 919/14 GUIDELINES FOR THE PREPARATION OF SAFETY DATA SHEETS PREPARED BY : Joachim Barbe Messer Group Ewoud Beheydt Praxair Gianluigi Colombo Sapio Produzione Idrogeno Ossigeno Joachim Eiselt Air Liquide Natalie Kingswood The Linde Group Zbigniew Sokolowski Air Products Ben Valk The Linde Group Pierre Wolfs EIGA Disclaimer All technical publications of EIGA or under EIGA's name, including Codes of practice, Safety procedures and any other technical information contained in such publications were obtained from sources believed to be reliable and are based on technical information and experience currently available from members of EIGA and others at the date of their issuance. While EIGA recommends reference to or use of its publications by its members, such reference to or use of EIGA's publications by its members or third parties are purely voluntary and not binding. Therefore, EIGA or its members make no guarantee of the results and assume no liability or responsibility in connection with the reference to or use of information or suggestions contained in EIGA's publications. EIGA has no control whatsoever as regards, performance or non performance, misinterpretation, proper or improper use of any information or suggestions contained in EIGA's publications by any person or entity (including EIGA members) and EIGA expressly disclaims any liability in connection thereto. -
Carcinogens CAS DOT SHHC Sources Number Chemical Name
2010 Right to Know Special Health Hazardous Substance List Substance Common Name Carcinogens CAS DOT SHHC Sources Number Chemical Name 3140 # ACEPHATE 30560-19-1 2783 CA 3 6 8 17 18 PHOSPHORAMIDOTHIOIC ACID, ACETYL-, O,S-DIMETHYL ESTER 0001 # ACETALDEHYDE 75-07-0 1089 CA MU TE F4 1 2 3 4 5 6 7 8 R2 15 17 18 20 21 ACETALDEHYDE 22 2890 # ACETAMIDE 60-35-5 3077 CA 3 6 7 17 18 20 ACETAMIDE 0010 # 2-ACETYLAMINOFLUORENE 53-96-3 CA MU 1 4 5 6 18 20 21 ACETAMIDE, N-9H-FLUOREN-2-YL- 0022 # ACRYLAMIDE 79-06-1 2074 CA R2 1 2 3 4 5 6 7 8 15 17 18 19 20 2-PROPENAMIDE 21 0024 # ACRYLONITRILE 107-13-1 1093 CA TE F3 R2 1 2 3 4 5 6 7 8 14 15 17 18 19 2-PROPENENITRILE 20 21 22 3142 # AF- 2 3688-53-7 CA 7 2-FURANACETAMIDE, .alpha.-[(5-NITRO-2-FURANYL)METHYLENE]- 0029 # AFLATOXINS 1402-68-2 CA MU TE 5 7 AFLATOXINS 0033 # ALDRIN 309-00-2 2761 CA TE 1 2 3 4 6 7 8 14 17 18 19 20 21 1,4:5,8-DIMETHANONAPHTHALENE, 1,2,3,4,10,10-HEXACHLORO-1,4,4a,5,8,8aHEXAHYDRO(1R,4S,4aS,5S,8R,8aR)-rel- Page 1 of 55 2010 Right to Know Special Health Hazardous Substance List Substance Common Name Carcinogens CAS DOT SHHC Sources Number Chemical Name 0039 # ALLYL CHLORIDE 107-05-1 1100 CA F3 1 2 3 4 6 7 8 15 17 18 20 1-PROPENE, 3-CHLORO- 0069 # 2-AMINOANTHRAQUINONE 117-79-3 CA MU 5 6 7 18 9,10-ANTHRACENEDIONE, 2-AMINO- 4012 # 1-AMINO-2,4-DIBROMOANTHRAQUINONE 81-49-2 CA 5 9,10-ANTHRACENEDIONE, 1-AMINO-2,4-DIBROMO- 0072 # 4-AMINODIPHENYL 92-67-1 CA MU 1 2 4 5 6 7 18 20 [1,1'-BIPHENYL]-4-AMINE 0076 # 1-AMINO-2-METHYLANTHRAQUINONE 82-28-0 CA 5 6 7 18 9,10-ANTHRACENEDIONE, 1-AMINO-2-METHYL- -
Carcinogens, Reproductive Toxins, and Teratogens
Environmental Health and Safety 2408 Wanda Daley Drive Ames, Iowa 50011-3602 Phone (515) 294-5359 www.ehs.iastate.edu Carcinogens, Reproductive Toxins, and Teratogens The materials on this list pose a significant risk of exposure or damage to the human body and require special procedures be developed for their safe use. Refer to page four of the Laboratory Safety Manual for more information. Materials involving industrial processes or manufacturing conditions which are not generally present at Iowa State University may have been omitted from this list. To ensure the current status of a chemical, check with the coordinating agency at the locations footnoted, a current safety data sheet (SDS) or call Environmental Health and Safety (EH&S) at (515) 294-5359. OSHA – Occupational Safety and Health Administration1 X – regulated carcinogen IARC – International Agency for Research on Cancer2 1 – known human carcinogen 2A – probable human carcinogen 2B – possible human carcinogen NTP – National Toxicology Program3 K – known carcinogen A – reasonably anticipated to be a carcinogen Repro Toxin – Reproductive Toxin X – material considered by one or more footnoted references to be harmful to adult reproductive systems Tera – Teratogen X – material considered by one or more footnoted references to cause birth defects in off-spring Repro SUBSTANCE OSHA IARC NTP Tera Toxin A-a-C (2-Amino-9H-pyrido[2,3-b]indole) 2B Acetaldehyde 2B A X Acetamide 2B 2-Acetylaminofluorene X A Page 1 of 32 Repro SUBSTANCE OSHA IARC NTP Tera Toxin Acheson process, occupational -
Particularly Hazardous Substances (Phs)
PARTICULARLY HAZARDOUS SUBSTANCES (PHS) This list contains examples of chemicals that may be used at the University of Nebraska Medical Center (UNMC). The list is not all-inclusive. This lists contains examples of Particularly Hazardous Substances (PHS) which are a special subset of OSHA Hazardous Chemicals. PHS include chemicals that are known or suspect carcinogens, reproductive toxins, and/or highly toxic materials. Before working with any PHS, please determine if you have any of these and evaluate if additional protective work practices are needed. You should utilize the PHS Assessment Form to help in this evaluation. Abbreviations Used in List Headings CARC NTP National Toxicology Program listed carcinogen - National Toxicology Program K = known carcinogen S = suspect carcinogen CARC IARC International Association for Research on Cancer listed carcinogen - IARC 1= known human carcinogen 2A = probable human carcinogen 2B = possible human carcinogen CARC OSHA OSHA regulated carcinogen - OSHA-regulated carcinogens X = regulated carcinogen REPRO SHEP Included in Catalog of Teratogenic Agents, T.H. Shepard, 6th Edition, Johns Hopkins Press, 1989 X = listed teratogen REPRO CALIF Listed by the State of California ‘Safe Drinking Water Act, 1986’ http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html F = female reproductive hazard M = male reproductive hazard HTX Highly toxic, included in EPA’s list ‘Acutely Toxic Hazardous Waste’, P-listed waste 40 CFR 261.33, or Included in OSHA’s list of highly hazardous chemicals with a threshold £200 -
Multi-Dimensional Mycelia Interactions
Multi-dimensional mycelia interactions A thesis submitted to Cardiff University for the degree of Doctor of Philosophy By Jade O’Leary, B.Sc (Hons) February 2018 DECLARATION This work has not been submitted in substance for any other degree or award at this or any other university or place of learning, nor is being submitted concurrently in candidature for any degree or other award. Signed ………………………………………… (candidate) Date ………………………… STATEMENT 1 This thesis is being submitted in partial fulfilment of the requirements for the degree of PhD. Signed ………………………………………… (candidate) Date ………………………… STATEMENT 2 This thesis is the result of my own independent work/investigation, except where otherwise stated. Other sources are acknowledged by explicit references. The views expressed are my own. Signed ………………………………………… (candidate) Date ………………………… STATEMENT 3 I hereby give consent for my thesis, if accepted, to be available for photocopying and for inter- library loan, and for the title and summary to be made available to outside organisations. Signed ………………………………………… (candidate) Date ………………………… STATEMENT 4: PREVIOUSLY APPROVED BAR ON ACCESS I hereby give consent for my thesis, if accepted, to be available for photocopying and for inter- library loans after expiry of a bar on access previously approved by the Academic Standards & Quality Committee. Signed ………………………………………… (candidate) Date ………………………… i Acknowledgements I would like to thank my supervisors, Dr Carsten Müller and Professor Dan Eastwood for all their time and advice, and especially Professor Lynne Boddy for her tireless dedication and infectious enthusiasm. Thanks to the Natural Environment Research Council (NERC) for studentship NE/L00243/1 and for funding UHPLC-MS analyses at the NERC Biomolecular Analysis Facility, Birmingham (NBAF-B).