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Heterotopic Ossification of the Elbow

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Heterotopic Ossification of the Elbow CHAPTER 38 Heterotopic Ossification of the Elbow Seth D. Dodds, MD • Douglas P. Hanel, MD Patient Presentation Indications The formation of ectopic bone about the elbow commonly The primary indication for operative resection of heterotopic presents following elbow trauma, significant neural axis bone and elbow contracture release is lack of elbow motion. injury, or major burns with symptoms of stiffness or complete Once heterotopic ossification has developed and restricted ankylosis.1 By definition, any ossification that forms in tissues elbow motion, it is nearly impossible to regain the lost motion which do not typically make bone is considered ectopic or with conservative measures, such as physical therapy, dynamic heterotopic. Patients who develop heterotopic ossification splinting, radiation therapy, or medication. Surgical resection of about the elbow can present with muscle, nerve, or joint heterotopic bone about the elbow should be considered in related pain, but most often express frustration due to lack of patients who present with an unacceptable loss of flexion/exten- passive and active motion. Loss of elbow motion leads to dra- sion or pronation/supination. Restoration of a functional arc of matic impairment in upper extremity function. For example, motion is the primary goal in active individuals. From a bio- a 50% loss of elbow motion will cause up to 80% impairment mechanical perspective, the functional arc of elbow motion has in upper extremity function.2 been demonstrated to be from 30° to 130° in the flexion/exten- The pathologic process behind ectopic bone formation sion plane and from 55° of pronation to 55° of supination in has not been fully elucidated. This lack of understanding the plane of forearm rotation.18 In an otherwise non-functional limits our ability to treat heterotopic bone formation both upper extremity, restoration of extension can even improve before and after it occurs. Certainly, the ideal management daily hygiene and nursing care. When considering the cosmetic of any elbow contracture due to heterotopic ossification is appearance of the arm, one group of authors believed that prevention. Early and consistent active range of motion achieving greater extension than 30° of flexion is needed for exercises,3-5 medical intervention such as indomethacin optimal patient satisfaction.9 and disphosphonates,6,7 or radiation therapy8 have all been Historically, surgical excision was delayed until maturity of proposed but remain unproven as potential treatment the heterotopic bone was proven.19 Guides to assessing the options for the prevention of heterotopic ossification about maturity of ectopic bone included normalization of the alka- the elbow. If it does occur, surgical excision and elbow con- line phosphatase level, quiescent bone scan, and a solidified tracture release are viable options for regaining elbow appearance on plain radiographs. However, recent reports of motion. outcomes after surgical excision have used only radiographic There are a few conditions that are associated with appearance of the lesion as a determining measure of matura- spontaneous formation of heterotopic bone about the tion.11,20-23 Along with questioning the need for additional elbow. Injury to bone, ligament, muscle, tendon, or joint tests to ascertain the maturity of the heterotopic bone, there capsule from the distal humerus to the proximal ulna or are case series which have investigated early excision of the radius can incite local ectopic bone formation.7,9-12 immature ossification.20,22-25 We do not believe there is suffi- Iatrogenic trauma, such as lateral epicondylectomy or cient scientific evidence to suggest that alkaline phosphatase elbow arthroscopy, have been reported to cause elbow het- chemistries or nuclear medicine scans are necessary to qualify erotopic ossification.13,14 Alternatively, trauma to the cen- the maturity (or lack thereof) of elbow heterotopic ossification. tral nervous system (including spinal cord injury) and The timing of surgical excision should be dependent on the debilitating burns have also been identified as risk factors patient’s presentation, the condition of the enveloping soft tis- for spontaneous formation of heterotopic bone about the sues, and the integrity of the crossing neurovascular structures. elbow.4,5,7,15-17 It is prudent to obtain sufficient radiographic imaging to under- American Society for Surgery of the Hand 425 Wrist and Elbow Reconstruction & Arthroscopy stand the extent of heterotopic ossification and elbow ankylosis more recent studies. Garland16 states the most common loca- prior to any definitive procedure. In patients with significant tion for heterotopic ossification after a central neurologic spinal cord or central nervous system trauma, surgical excision injury is either posterolateral (from the posterolateral humeral should be until maximal motor recovery occurs, which can be condyle to the posterolateral olecranon, fixing the elbow at as long as 1 to 1.5 years after initial injury.19,26 If there are burn 30° of flexion) or anterior within the brachialis. Another typ- wounds present about the elbow, these should be entirely healed ical location for ectopic bone formation about the elbow is prior to creating a new incision.5,23 Neurologic, vascular, and between the radius and the ulna, causing a proximal radioul- lymphatic systems must be assessed and their status docu- nar synostosis (Figure 3). mented and appropriately prioritized.27 For instance, the ulnar Hastings and Graham29 proposed a classification system nerve can be encased in heterotopic bone causing cubital tun- of elbow ectopic bone formation. There are three groups or nel symptoms which may dictate an earlier timing of sur- classes based on functional range of motion which those gery.22,27,28 The integrity of the skin and subcutaneous tissues authors felt would be helpful in both assessment and treat- should be evaluated. Lingering soft tissue swelling, edema, or ment. Class I includes patients with positive radiographs for erythema may all point to additional diagnoses that must be heterotopic ossification, but no functional limitations. dealt with before deciding upon heterotopic bone resection. In Class II radiographs demonstrate heterotopic ossification, a majority of cases, we proceed with surgical resection when the and there is a functional limitation—either in the flex- soft tissue envelope is quiescent. ion/extension axis (Class IIA), the pronation/supination axis (Class IIB), or both (Class IIC). Class III patients have ectopic bone with ankylosis either in flexion/extension Relevant Anatomy (Class IIIA), pronation/supination (Class IIIB), or both It is critical to have a firm understanding of the neurovascular (Class IIIC).1,29 structures that cross this joint, as well as their typical relation- ships to surrounding structures. Frequently, when ectopic bone is being excised about the elbow, the surgeon is working Clinical Studies (Outcomes) in a previously scarred area where nerves may have been dis- The majority of outcome studies on surgical excision are ret- sected, mobilized, or even transposed. The proximity of het- rospective reviews with small numbers of patients, as this is a erotopic ossification to any nerve or blood vessel adds relatively uncommon procedure in the realm of orthopaedic considerable risk to surgical excision. Patients must be aware surgery. Studies are varied in their operative approaches, as of the potential for iatrogenic neurovascular injury prior to well as in their post-operative protocols. Typically, most cases signing informed consent. are treated on an individual basis according to each patient’s The cutaneous nerves that require diligence are the poste- prior surgery, the condition of the overlying soft tissues, and rior brachial cutaneous nerve and the medial and lateral ante- the surgeon’s preference for maintaining motion and prevent- brachial cutaneous nerves to the forearm. The main peripheral ing the recurrence of heterotopic bone post-operatively. nerves to identify are the median, ulnar, and radial, including Viola and Hanel20 reported on 15 cases of early release the posterior interosseous nerve distally. Lastly, the operating (24–78 weeks of initial injury) for post-traumatic elbow con- surgeon must always be aware of the location of the brachial tractures with heterotopic ossification. These authors were artery. The dissection and identification of these anatomic able to achieve a mean flexion/extension arc of 120° and a structures will be reviewed within the description of the sur- mean pronation/supination arc of 152° at an average follow gical technique. up of 115 weeks. Here, indomethacin and continuous passive Heterotopic bone can occur anywhere about the elbow, motion were used post-operatively in most cases. Morimoto et but it is typically posterior, deep to the triceps extending from al.24 studied nine consecutive patients who underwent early either epicondyle to the olecranon, or anterior, associated with excision (mean 7.7 months from initial injury) of medial- the brachialis (Figures 1, 2). Evans5 believed that heterotopic sided heterotopic ossification. Those authors found 112° of bone forms and matures along a line from the olecranon to flexion and extension at an average follow up of 52 months. the medial epicondylar ridge of the humerus at the medial Recurrence of elbow stiffness did not occur despite radi- border of the triceps. This has been confirmed as a common ographic evidence of spotty heterotopic
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