Latent cause inference during extinction learning in trauma-exposed individuals with and without PTSD Agnes Norbury1*, Hannah Brinkman1, Mary Kowalchyk1, Elisa Monti1, Robert H Pietrzak2,3, Daniela Schiller1,4, Adriana Feder1 1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA 2Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA 3Unite States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA 4Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA *Corresponding author: Agnes Norbury, One Gustave L. Levy Place, Department of Psychiatry, Box 1230, New York, NY 10029, USA. Email:
[email protected] Abstract Background Problems in learning that sights, sounds, or situations that were once associated with danger have become safe (extinction learning) may explain why some individuals suffer prolonged psychological distress following traumatic experiences. Although simple learning models have been unable to provide a convincing account of why this learning fails, it has recently been proposed that this may be explained by individual differences in beliefs about the causal structure of the environment. Methods Here, we tested two competing hypotheses as to how differences in causal inference might be related to trauma-related psychopathology, using extinction learning data collected from clinically well-characterized individuals with varying degrees of post-traumatic stress (N=56). Model parameters describing individual differences in causal inference were related to multiple PTSD and depression symptom dimensions via network analysis. Results Individuals with more severe PTSD were more likely to assign observations from conditioning and extinction stages to a single underlying cause.