Dataset for Penile and Distal Urethral Cancer Histopathology Reports

Total Page:16

File Type:pdf, Size:1020Kb

Dataset for Penile and Distal Urethral Cancer Histopathology Reports Standards and datasets for reporting cancers Dataset for penile and distal urethral cancer histopathology reports July 2015 Authors: Dr Catherine Corbishley (lead author), St George’s Healthcare NHS Trust, London Dr Jon Oxley, Southmead Hospital Bristol Dr Jonathan H Shanks, The Christie NHS Foundation Trust, Manchester Dr Brendan Tinwell, St George’s Healthcare NHS Trust, London Unique document number G038 Document name Dataset for penile and distal urethral cancer histopathology reports Version number 3 Produced by Dr Catherine Corbishley (honorary consultant urological histopathologist, member of Penile Subgroup of National Cancer Intelligence Network, Urology Clinical Reference Group, founder member British Association of Urological Pathologists [BAUP]); Dr Jon Oxley (consultant histopathologist; lead penile pathologist South West England supranetwork, Urology National EQA co- organiser); Dr Jonathan Shanks (lead penile pathologist North West England supranetwork) and Dr Brendan Tinwell (consultant urological pathologist and illustrator) on behalf of the RCPath Working Group on Cancer Services. All authors work in supraregional penile cancer centres and are members of the UK National Penile Pathology Group and the BAUP. Date active July 2015 Date for full review July 2018 Comments In accordance with the College’s pre-publications policy, this document was on The Royal College of Pathologists’ website for consultation from 6 May to 3 June 2015. Nineteen items of feedback were received. The authors considered them and amended the document as appropriate. Please email [email protected] if you wish to see the responses and comments. This document replaces early editions of Dataset for penile cancer histopathology reports, published in 2006 and June 2015 (which mistakenly contained a short duplicated section in Appendix A). Dr David Bailey Vice-President for Communications The Royal College of Pathologists Fourth Floor, 21 Prescot Street, London, E1 8BB Tel: 020 7451 6700 Fax: 020 7451 6701 Web: www.rcpath.org Registered charity in England and Wales, no. 261035 © 2015, The Royal College of Pathologists This work is copyright. You may download, display, print and reproduce this document for your personal, non-commercial use. Apart from any use as permitted under the Copyright Act 1968 or as set out above, all other rights are reserved. Requests and inquiries concerning reproduction and rights should be addressed to The Royal College of Pathologists at the above address. First published: 2015 CEff 100715 1 V1 Final Contents Foreword ........................................................................................................................................ 3 1 Introduction ............................................................................................................................ 4 2 Specimen request form .......................................................................................................... 6 3 Preparation of specimens before dissection ........................................................................... 7 4 Specimen handling and blocking............................................................................................ 7 5 Core data items to be included in the report ........................................................................ 10 6 Core data items (summary) .................................................................................................. 15 7 Non-core data items ............................................................................................................. 15 8 Diagnostic coding and staging ............................................................................................. 16 9 Special techniques including sentinel nodes ....................................................................... 16 10 Frozen section diagnosis .................................................................................................... 16 11 Criteria for audit of the dataset ............................................................................................. 17 12 Acknowledgements .............................................................................................................. 17 13 References .......................................................................................................................... 18 Appendices A TNM pathological staging of penile and distal urethral tumours (7th edition, UICC) ............. 22 B SNOMED coding of penile and distal urethral tumours ........................................................ 25 C Reporting proforma for penile tumours ................................................................................. 27 D Reporting proforma for distal urethral tumours ..................................................................... 30 E Reporting proforma for lymph node specimens from patients with penile or urethral carcinoma ........................................................................................................... 33 F Reporting proforma for penile tumours in list format ......................................................... 35 G Reporting proforma for distal urethral tumours in list format ............................................ 39 H Reporting proforma for lymph node specimens from patients with penile or urethral carcinoma in list format .................................................................................... 43 I Diagrammatic representations of penile anatomy and specimen types ............................... 46 J Summary table – Explanation of levels of evidence ............................................................. 49 K AGREE compliance monitoring sheet .................................................................................. 50 NICE has accredited the process used by The Royal College of Pathologists to produce its Cancer Datasets and Tissue Pathways guidance. Accreditation is valid for 5 years from July 2012. More information on accreditation can be viewed at www.nice.org.uk/accreditation. For full details on our accreditation visit: www.nice.org.uk/accreditation. CEff 100715 2 V1 Final Foreword The cancer datasets published by The Royal College of Pathologists (RCPath) are a combination of textual guidance, educational information and reporting proformas. The datasets enable pathologists to grade and stage cancers in an accurate, consistent manner in compliance with international standards and provide prognostic information, thereby allowing clinicians to provide a high standard of care for patients and appropriate management for specific clinical circumstances. It may rarely be necessary or even desirable to depart from the guidelines in the interests of specific patients and special circumstances. The clinical risk of departing from the guidelines should be assessed by the relevant multidisciplinary team (MDT); just as adherence to the guidelines may not constitute defence against a claim of negligence, so deviation from them should not necessarily be deemed negligent. Each dataset contains core data items that are mandated for inclusion in the Cancer Outcomes and Services Dataset (COSD – previously the National Cancer Data Set) in England. Core data items are items that are supported by robust published evidence and are required for cancer staging, optimal patient management and prognosis. Core data items meet the requirements of professional standards (as defined by the Information Standards Board for Health and Social Care [ISB]) and it is recommended that at least 90% of reports on cancer resections should record a full set of core data items. Other, non-core, data items are described. These may be included to provide a comprehensive report or to meet local clinical or research requirements. All data items should be clearly defined to allow the unambiguous recording of data. The following organisations have been consulted in the writing of this dataset: The UK National Penile Pathology Group (‘the Hobnobs’) British Association of Urological Pathologists (BAUP) British Association of Urological Surgeons (BAUS), including sections of oncology and andrology British Uro-oncology Group (BUG) European Association of Urology (EAU) Penile Guidelines Subgroup UK Association of Cancer Registries (UKACR) Penile Subgroup of National Cancer Intelligence Network (NCIN) Urology Clinical Reference Group British Association of Dermatopathologists. Evidence for the data items in the dataset is derived from consensus of recognised experts together with review of current literature. Evidence has been graded using modified SIGN guidance (see Appendix G). The following is a list of supporting evidence and guidelines used in the dataset: Pubmed searches on penile and distal urethral tumours (up to December 2014) WHO classification of tumours of the urinary system and male genital organs, 20041 TNM (7th edition), 20092 NICE Improving outcomes in urological cancers, 2002 www.nice.org.uk/guidance/csguc Evidence guide for urology supraregional penile MDT NHS National Cancer Peer Review Programme, 2010 www.cquins.nhs.uk/?menu=resources CEff 100715 3 V1 Final EAU penile cancer guidelines, 20154 EAU Guidelines on Primary Urethral Carcinoma, 2013. Gakis G, Witjes, JA, Comperat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM www.guideline.gov/content.aspx?id=45318 College of American Pathologists (CAP) Protocol for the Examination of Specimens from Patients with Carcinoma of the Penis,
Recommended publications
  • Part 2-Organ-Sparing Procedures in Testicular and Penile Tumors
    International Urology and Nephrology (2019) 51:1699–1708 https://doi.org/10.1007/s11255-019-02182-6 UROLOGY - REVIEW Organ‑sparing procedures in GU cancer: part 2‑organ‑sparing procedures in testicular and penile tumors Mohamed H. Kamel1,3 · Mahmoud I. Khalil1,3 · Ehab Eltahawy1,3 · Rodney Davis1 · Nabil K. Bissada2 Received: 1 May 2019 / Accepted: 23 May 2019 / Published online: 2 July 2019 © Springer Nature B.V. 2019 Abstract Purpose Organ-sparing surgery (OSS) is recommended in selected patients with testicular tumors and penile cancer (PC). The functional and psychological impacts of organ excision for these genital tumors are profound. In this review, we sum- marize the indications, techniques and outcomes of OSS for these two tumors. Methods PubMed® was searched for relevant articles up to December 2018. For Testicular sparing surgery (TSS) search, keywords used were; testicular tumors alone and in combination with “testicular sparing surgery”, “partial orchiectomy” and outcomes. For penile conserving surgery (PCS), keywords used were: penile cancer alone and in combination with “penile conserving surgery”, “partial penectomy” and outcomes. Because of the low quality of available evidence, a narrative rather that systematic review has been performed. Results Indications of TSS are tumors ≤ 2 cm in solitary testis or bilateral tumors and no rete testis invasion. Prerequisites include normal testosterone and luteinizing hormone levels and patient compliance with follow-up. Indications for PCS are distal penile lesions with clinical stage ≤ T1. Adequate penile stump (3 cm) is required after surgery to maintain forward urine stream. Frozen section helps to reduce the risk of recurrence. Local recurrence after PCS is not associated with reduced survival and can be managed with another PCS in selected patients.
    [Show full text]
  • EAU Guidelines on Penile Cancer 2001
    European Association of Urology GUIDELINES ON PENILE CANCER* F. Algaba, S. Horenblas, G. Pizzocaro, E. Solsona, T. Windahl TABLE OF CONTENTS PAGE 1. Background 3 2. Classification 3 2.1 Pathology 3 2.2 References 4 3. Risk factors 5 3.1 References 5 4. Diagnosis 6 4.1 Primary lesion 6 4.2 Regional nodes 6 4.3 Distant metastases 7 4.4 Guidelines on the diagnosis of penile cancer 8 4.5 References 8 5. Treatment 9 5.1 Primary lesion 9 5.2 Regional nodes 9 5.3 Guidelines on the treatment of penile carcinoma 11 5.4 Integrated therapy 11 5.5 Distant metastases 11 5.6 Quality life 11 5.7 Technical aspects 12 5.8 Chemotherapy 12 5.9 References 14 6. Follow-up 15 6.1 Why follow-up? 15 6.2 How to follow-up 16 6.3 When to follow-up 16 6.4 Guidelines for follow-up in penile cancer 17 6.5 References 18 7. Abbreviations used in the text 19 2 1. BACKGROUND Penile carcinoma is an uncommon malignant disease with an incidence ranging from 0.1 to 7.9 per 100,000 males. In Europe, the incidence is 0.1–0.9 and in the US, 0.7–0.9 per 100,000 (1). In some areas, such as Asia, Africa and South America, penile carcinoma accounts for as many as 10–20% of male cancers. Phimosis and chronic irritation processes related to poor hygiene are commonly associated with this tumour, whereas neonatal circumcision gives protection against the disease.
    [Show full text]
  • Gender Affirming Surgery and Related Procedures State(S): LOB(S): Idaho Montana Oregon Washington Other: Commercial Medicare Medicaid
    Gender Affirming Surgery and Related Procedures State(s): LOB(s): Idaho Montana Oregon Washington Other: Commercial Medicare Medicaid Enterprise Policy BACKGROUND The American Psychiatric Association’s Diagnostic and Statistical Manual, 5th Edition (DSM 5) defines criterion A of Gender Dysphoria as “a marked incongruence between one’s experience/expressed gender and assigned gender.” These individuals must meet additional criteria which include persistence over time and clinically significant distress or impairment in social, occupational or other important areas of functioning. Benefits must be verified by reviewing the plan’s contract or plan document (PD). Some PacificSource benefit plans do not include coverage of gender affirming surgery, procedures or other related treatment. Groups may elect to customize these benefits; therefore, benefit determinations are based on specific contract language. CRITERIA The member should be placed into case management by Health Services as a way to help the member understand their benefits and required criteria related to gender affirming surgery and treatment, and to assist her/him to navigate the system and promote an optimal outcome. Covered Services and Exclusions – Commercial, Medicaid 1. The following are considered medically necessary gender affirming surgeries. a. Core surgical procedures considered medically necessary for females transitioning to males include: hysterectomy, vaginectomy, salpingo-oophorectomy, metoidioplasty, phalloplasty, urethroplasty, scrotoplasty, perineal electrolysis, and placement of testicular implant and mastectomy including nipple reconstruction. b. Core surgical procedures considered medically necessary for males transitioning to females include: penectomy, orchiectomy, vaginoplasty, clitoroplasty, perineal electrolysis, labiaplasty, and mammoplasty when 12 continuous months of hormonal (estrogen) therapy has failed to result in breast tissue growth of Tanner Stage 5 on the puberty scale or there is any contraindication to, or intolerance of, or patient refusal of hormone therapy.
    [Show full text]
  • Delineation of Privileges Urology Privileges Provider Name
    Delineation Of Privileges Urology Privileges Provider Name: Privilege Requested Deferred Approved UROLOGY PRIVILEGES Criteria - New Applicants:: Board Certification or qualified for certification by the American Board of Urology. Criteria - Current Staff Members Only: Successful completion of an ACGME or AOA approved training program; OR demonstrated acceptable practice in the privileges being requested for a minimum of five (5) years. Proctoring Requirements: A minimum of eight (8) cases, in accordance with the Medical Staff Proctoring Protocol. GENERAL PRIVILEGES: Admit ___ ___ ___ Consultation Only Privileges ___ ___ ___ Surgical Assist Only ___ ___ ___ Local block anesthesia ___ ___ ___ Regional block anesthesia ___ ___ ___ Sedation analgesia ___ ___ ___ Criteria: Requires successful completion of the Sedation Assessment test. Additional criteria effective April 1, 2015: a) Evidence of current ACLS and/or PALS certification from the American Heart Association; AND b) Evidence of completion of an Airway Management Course a) Adult Sedation ___ ___ ___ b) Pediatric Sedation (17 years and under) ___ ___ ___ CATEGORY 1 - UROLOGY PRIVILEGES ___ ___ ___ Includes the management and coordination of care, treatment and services, including: medical history and physical evaluations, consultations and prescribing medication in accordance with DEA certificate. Urethral, bladder catheterization ___ ___ ___ Suprapubic, bladder aspiration ___ ___ ___ Page 1 Printed on Wednesday, December 10, 2014 Delineation Of Privileges Urology Privileges Provider
    [Show full text]
  • A Comprehensive Review of a Rare Subclass of Mucosal Melanoma with Emphasis on Differential Diagnosis and Therapeutic Approaches
    cancers Review Urological Melanoma: A Comprehensive Review of a Rare Subclass of Mucosal Melanoma with Emphasis on Differential Diagnosis and Therapeutic Approaches Gerardo Cazzato 1,*,† , Anna Colagrande 1,†, Antonietta Cimmino 1, Concetta Caporusso 1, Pragnell Mary Victoria Candance 1, Senia Maria Rosaria Trabucco 1, Marcello Zingarelli 2, Alfonso Lorusso 2, Maricla Marrone 3 , Alessandra Stellacci 3 , Francesca Arezzo 4, Andrea Marzullo 1, Gabriella Serio 1, Angela Filoni 5, Domenico Bonamonte 5, Paolo Romita 5, Caterina Foti 5, Teresa Lettini 1 , Vera Loizzi 4, Gennaro Cormio 4 , Leonardo Resta 1 , Roberta Rossi 1,‡ and Giuseppe Ingravallo 1,‡ 1 Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy; [email protected] (A.C.); [email protected] (A.C.); [email protected] (C.C.); [email protected] (P.M.V.C.); [email protected] (S.M.R.T.); [email protected] (A.M.); [email protected] (G.S.); [email protected] (T.L.); [email protected] (L.R.); [email protected] (R.R.); [email protected] (G.I.) 2 Section of Urology, Deparment of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy; [email protected] (M.Z.); [email protected] (A.L.) 3 Section of Legal Medicine, Interdisciplinary Department of Medicine, Bari Policlinico Hospital, Citation: Cazzato, G.; Colagrande, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy; [email protected] (M.M.); A.; Cimmino, A.; Caporusso, C.; [email protected] (A.S.) Candance, P.M.V.; Trabucco, S.M.R.; 4 Section of Ginecology and Obstetrics, Department of Biomedical Sciences and Human Oncology, Zingarelli, M.; Lorusso, A.; Marrone, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy; [email protected] (F.A.); M.; Stellacci, A.; et al.
    [Show full text]
  • Provider Guide
    Physician-Related Services/ Health Care Professional Services Provider Guide July 1, 2015 Physician-Related Services/Health Care Professional Services About this guide* This publication takes effect July 1, 2015, and supersedes earlier guides to this program. Washington Apple Health means the public health insurance programs for eligible Washington residents. Washington Apple Health is the name used in Washington State for Medicaid, the children's health insurance program (CHIP), and state- only funded health care programs. Washington Apple Health is administered by the Washington State Health Care Authority. What has changed? Subject Change Reason for Change Medical Policy Updates Added updates from the Health Technology Clinical In accordance with WAC Committee (HTCC) 182-501-0055, the agency reviews the recommendations of HTCC and decides whether to adopt the recommendations Bariatric surgeries Removed list of agency-approved COEs and added Clarification link to web page for approved COEs Update to EPA Removed CPT 80102 CPT Code Update 870000050 Added CPT 80302 Maternity and delivery – Added intro paragraph for clarification of when to Clarification Billing with modifiers bill using modifier GB. Also updated column headers for modifiers Immune globulins Replacing deleted codes Q4087, Q4088, Q4091, and Updating deleted codes Q4092 with J1568, J1569, J1572, and J1561 Bilateral cochlear implant EPA 870001365 fixed diagnosis code 398.18 Corrected typo Newborn care The agency pays a collection fee for a newborn Clarification metabolic screening panel. The screening kit is provided free from DOH. Vaccines/Toxoids Add language “Routine vaccines are administered Clarification (Immunizations) according to current Centers for Disease Control (CDC) advisory committee on immunization practices (ACIP) immunization schedule for adults and children in the United States.” Injectable and nasal flu Adding link to Injectable Fee Schedule for coverage Clarification vaccines details * This publication is a billing instruction.
    [Show full text]
  • Clinical Radiation Oncology Review
    Clinical Radiation Oncology Review Daniel M. Trifiletti University of Virginia Disclaimer: The following is meant to serve as a brief review of information in preparation for board examinations in Radiation Oncology and allow for an open-access, printable, updatable resource for trainees. Recommendations are briefly summarized, vary by institution, and there may be errors. NCCN guidelines are taken from 2014 and may be out-dated. This should be taken into consideration when reading. 1 Table of Contents 1) Pediatrics 6) Gastrointestinal a) Rhabdomyosarcoma a) Esophageal Cancer b) Ewings Sarcoma b) Gastric Cancer c) Wilms Tumor c) Pancreatic Cancer d) Neuroblastoma d) Hepatocellular Carcinoma e) Retinoblastoma e) Colorectal cancer f) Medulloblastoma f) Anal Cancer g) Epndymoma h) Germ cell, Non-Germ cell tumors, Pineal tumors 7) Genitourinary i) Craniopharyngioma a) Prostate Cancer j) Brainstem Glioma i) Low Risk Prostate Cancer & Brachytherapy ii) Intermediate/High Risk Prostate Cancer 2) Central Nervous System iii) Adjuvant/Salvage & Metastatic Prostate Cancer a) Low Grade Glioma b) Bladder Cancer b) High Grade Glioma c) Renal Cell Cancer c) Primary CNS lymphoma d) Urethral Cancer d) Meningioma e) Testicular Cancer e) Pituitary Tumor f) Penile Cancer 3) Head and Neck 8) Gynecologic a) Ocular Melanoma a) Cervical Cancer b) Nasopharyngeal Cancer b) Endometrial Cancer c) Paranasal Sinus Cancer c) Uterine Sarcoma d) Oral Cavity Cancer d) Vulvar Cancer e) Oropharyngeal Cancer e) Vaginal Cancer f) Salivary Gland Cancer f) Ovarian Cancer & Fallopian
    [Show full text]
  • Medical, Legal, Psychosocial, and Ethical Issues of Penile Transplants for Injured Veterans in the United States a Ochasi, N Sopko, G Mamo, V Pepe, a L Burnett, II
    The Internet Journal of Law, Healthcare and Ethics ISPUB.COM Volume 11 Number 1 Penile Transplants: To Do or Not To Do: Medical, Legal, Psychosocial, and Ethical Issues of Penile Transplants for Injured Veterans in the United States A Ochasi, N Sopko, G Mamo, V Pepe, A L Burnett, II Citation A Ochasi, N Sopko, G Mamo, V Pepe, A L Burnett, II. Penile Transplants: To Do or Not To Do: Medical, Legal, Psychosocial, and Ethical Issues of Penile Transplants for Injured Veterans in the United States. The Internet Journal of Law, Healthcare and Ethics. 2016 Volume 11 Number 1. DOI: 10.5580/IJLHE.47425 Abstract The genitourinary injuries sustained by soldiers in Iraq and Afghanistan, which make urination, sexual intimacy and fathering a child, more difficult, can cause psychological distress for men, and may even lead to depression. To help ease the burden, Johns Hopkins University has approved a series of 60 experimental penile transplants on wounded veterans with such injuries following the first successful surgery in the US in May of 2016. This article addresses the permissibility of this procedure from the medical, legal, regulatory, sociocultural, religious and ethical perspectives. Medically, since penile transplant fits into the emerging new field of vascularized composite allograft (VCA) there are concerns about the risks for life-long immunosuppression, infection and malignancy. Other concerns include patient’s expectations, donor shortage and lack of public awareness. Legally, the procedure raises issues about the informed consent of donor and recipient, compliance and privacy, as well as need to require a different set of screening procedures and criteria for donation.
    [Show full text]
  • Urinary Bladder Neoplasia
    Canine Urinary Tract Neoplasia Phyllis C Glawe DVM, MS The principal organs of the urinary tract are the kidneys, ureters, urinary bladder and urethra. The urinary bladder and urethra are the most commonly affected by cancer in the dog and the majority of cancers in these locations are malignant. The most common type of cancer is Transitional Cell Carcinoma (TCC). This handout reviews the facts about clinical symptoms, diagnosis and treatment of urinary tract cancer in the dog. Clinical Features More common in female dogs, urinary bladder and urethral cancer are typically associated with advanced age (9-10 years). Frequent urination, blood in the urine, and straining to urinate are typical symptoms. These signs are also similar to those of urinary tract infections, thus a cancer diagnosis can be missed early in the course of the disease. If the flow of urine is obstructed, abdominal pain, vomiting, depression and loss of appetite can occur. More rarely, dogs can present with back pain and weakness of the hind limbs due to metastases (spread) of the cancer to the spine and lymph nodes. Diagnosis Abdominal radiographs and abdominal ultrasound can be utilized to detect cancer in the lower urinary tract. Abdominal ultrasound is particularly helpful to assess whether other organs in the abdomen region are affected, such as the kidneys and ureters. Hydronephrosis and hydroureter are terms describing a back-up of urine flow due to the obstructive effects of a tumor. Regional lymph node enlargement and possible prostate enlargement in male dogs can be assessed quickly and accurately with ultrasound. Urine analysis is not very helpful as a diagnostic tool in most cases.
    [Show full text]
  • Penile Cancer
    Guidelines on Penile Cancer O.W. Hakenberg (chair), E. Compérat, S. Minhas, A. Necchi, C. Protzel, N. Watkin © European Association of Urology 2014 TABLE OF CONTENTS PAGE 1. INTRODUCTION 4 1.1 Publication history 4 1.2 Potential conflict of interest statement 4 2. METHODOLOGY 4 2.1 References 5 3. DEFINITION OF PENILE CANCER 5 4. EPIDEMIOLOGY 5 4.1 References 6 5. RISK FACTORS AND PREVENTION 7 5.1 References 8 6. TNM CLASSIFICATION AND PATHOLOGY 9 6.1 TNM classification 9 6.2 Pathology 10 6.2.1 References 13 7. DIAGNOSIS AND STAGING 15 7.1 Primary lesion 15 7.2 Regional lymph nodes 15 7.2.1 Non-palpable inguinal nodes 15 7.2.2 Palpable inguinal nodes 16 7.3 Distant metastases 16 7.4 Recommendations for the diagnosis and staging of penile cancer 16 7.5 References 16 8. TREATMENT 17 8.1 Treatment of the primary tumour 17 8.1.1 Treatment of superficial non-invasive disease (CIS) 18 8.1.2 Treatment of invasive disease confined to the glans (category Ta/T1a) 18 8.1.2.1 Results of different surgical organ-preserving treatment modalities 18 8.1.2.2 Summary of results of surgical techniques 19 8.1.2.3 Results of radiotherapy for T1 and T2 disease 19 8.1.3 Treatment of invasive disease confined to the corpus spongiosum/glans (Category T2) 20 8.1.4 Treatment of disease invading the corpora cavernosa and/or urethra (category T2/T3) 20 8.1.5 Treatment of locally advanced disease invading adjacent structures (category T3/T4) 20 8.1.6 Local recurrence after organ-conserving surgery 20 8.1.7 Recommendations for stage-dependent local treatment of penile carcinoma.
    [Show full text]
  • Primary Urethral Carcinoma
    EAU Guidelines on Primary Urethral Carcinoma G. Gakis, J.A. Witjes, E. Compérat, N.C. Cowan, V. Hernàndez, T. Lebret, A. Lorch, M.J. Ribal, A.G. van der Heijden Guidelines Associates: M. Bruins, E. Linares Espinós, M. Rouanne, Y. Neuzillet, E. Veskimäe © European Association of Urology 2017 TABLE OF CONTENTS PAGE 1. INTRODUCTION 3 1.1 Aims and scope 3 1.2 Panel composition 3 1.3 Publication history and summary of changes 3 1.3.1 Summary of changes 3 2. METHODS 3 2.1 Data identification 3 2.2 Review 3 2.3 Future goals 4 3. EPIDEMIOLOGY, AETIOLOGY AND PATHOLOGY 4 3.1 Epidemiology 4 3.2 Aetiology 4 3.3 Histopathology 4 4. STAGING AND CLASSIFICATION SYSTEMS 5 4.1 Tumour, Node, Metastasis (TNM) staging system 5 4.2 Tumour grade 5 5. DIAGNOSTIC EVALUATION AND STAGING 6 5.1 History 6 5.2 Clinical examination 6 5.3 Urinary cytology 6 5.4 Diagnostic urethrocystoscopy and biopsy 6 5.5 Radiological imaging 7 5.6 Regional lymph nodes 7 6. PROGNOSIS 7 6.1 Long-term survival after primary urethral carcinoma 7 6.2 Predictors of survival in primary urethral carcinoma 7 7. DISEASE MANAGEMENT 8 7.1 Treatment of localised primary urethral carcinoma in males 8 7.2 Treatment of localised urethral carcinoma in females 8 7.2.1 Urethrectomy and urethra-sparing surgery 8 7.2.2 Radiotherapy 8 7.3 Multimodal treatment in advanced urethral carcinoma in both genders 9 7.3.1 Preoperative platinum-based chemotherapy 9 7.3.2 Preoperative chemoradiotherapy in locally advanced squamous cell carcinoma of the urethra 9 7.4 Treatment of urothelial carcinoma of the prostate 9 8.
    [Show full text]
  • Surgical Principles of Penile Cancer for Penectomy and Inguinal Lymph Node Dissection: a Narrative Review
    11 Review Article Page 1 of 11 Surgical principles of penile cancer for penectomy and inguinal lymph node dissection: a narrative review Nathaniel D. Coddington1, Kirk D. Redger2, Ty T. Higuchi2 1Division of Urology, Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA; 2Division of Urology, Department of Surgery, University of Colorado, Aurora, CO, USA Contributions: (I) Conception and design: ND Coddington, TT Higuchi; (II) Administrative support: TT Higuchi; (III) Provision of study materials or patients: ND Coddington, TT Higuchi; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Ty T. Higuchi, MD. Division of Urology, Department of Surgery, University of Colorado, 12605 E. 16th Ave, Aurora, CO 80045, USA. Email: [email protected]. Abstract: Penile cancer is a rare and serious disease. Early local and regional disease is surgically curable, but advanced regional disease portends a poor prognosis—with inguinal node metastases being the most important prognostic factor. An initial histologic diagnosis with a punch, excisional, or incisional biopsy is recommended to determine the risk of lymph node involvement prior to proceeding with surgery. Magnetic resonance imaging (MRI) or ultrasound can used adjunctively to determine the depth of invasion. Total or partial penectomy with 5mm resection margins is the standard of care for primary disease, although penile- preserving procedures—such as circumcision for preputial lesions, laser ablation, wide local excision, glans resurfacing, glansectomy, and Mohs micrographic surgery—are initially indicated for tumors of lower grade, favorable histology, and favorable location.
    [Show full text]