Scientific Report 2014

Ente Ospedaliero Cantonale Index

Preface 5 4. Swiss Clinical Trial Organization 87 4.1 EOC Clinical Trial Unit (CTU-EOC) 88 1. Oncology Institute of Southern Switzerland (IOSI) 9 1.1 Medical Oncology Service 11 5. Scientific Research Advisory Board (ABREOC) 91 1.2 Radiation Oncology Service 12 1.3 Medical Physics Unit of the Radiation Oncology Service 16 6. Official Registry of the EOC clinical studies 95 1.4 Nuclear Medicine Service and PET/CT Centre 17 (EOC Database of clinical studies) 1.5 Palliative Care Service 20 1.6 Haematology Service 21 7. Publications in 2014 99 1.7 Research Division 23 Publications in peer-reviewed journals in 2014 104 1.8 IOSI Nursing Service 31 Publications in non-peer-reviewed journals in 2014 129 Communications at medical conference in 2014 130 2. Neurocenter of Southern Switzerland (NSI) 35 Publications in books in 2014 156 2.1 Multiple Sclerosis Centre 36 2.2 Sleep and Epilepsy group 39 8. Appendices 159 2.3 Movement Disorders Centre 42 Appendix 1 - Research projects funded by ABREOC in 2008 160 2.4 Stroke Centre 45 Appendix 2 - Research projects funded by ABREOC in 2009 162 2.5 Neuropsychology 46 Appendix 3 - Research projects funded by ABREOC in 2010 164 2.6 Neurosurgery 47 Appendix 4 - Research projects funded by ABREOC in 2011 168 2.7 Neuroradiology 50 Appendix 5 - Research projects funded by ABREOC in 2012 - 2013 170 2.8 Neuroanaesthesia 51 Appendix 6 - Research projects funded by ABREOC in 2014 172 2.9 Laboratory for Biomedical Neurosciences (LBN) 52 Appendix 7 - 2014 EOC Projects subject to General Authorisation (AG) 172 3. EOC Multisite Departments and Services 59 3.1 EOC Department of Surgery 60 3.2 EOC Department of Internal Medicine 64 3.3 EOC Department of Intensive Care Medicine 74 3.4 EOC Department of Laboratory Medicine 75 3.5 Paediatrics Services 76 3.6 Anaesthesiology Services 80 3.7 Dermatology and Allergology/Clinical Immunology Services 80 3.8 Geriatric Service 81 3.9 Radiology Services 82

Together for a better care

Preface Preface

For the EOC, the year 2014 was characterized This positive development in quality of translational Furthermore, I would like to highlight that the I would like to end by mentioning a famous quote: by a high scientific productivity. Indeed, scientific and clinical research activities, conducted within Official Registry of the EOC clinical studies has “The ultimate goal of our hard work is not the productivity of the EOC continued its upward the hospitals and Institutes of the EOC, is one been created and has been effective since April reward, it is the pleasure of making the best use of trend as per quantity and quality of its publications of the fundamental pillars within the newly- 2014 (see chapter 6). cognitive abilities belonging to Homo Sapiens. (+62% of 2011 peer-reviewed publications, see established Human Medicine Master of the Currently, 222 studies are entered into the (Lo scopo ultimo di quanto si produce non è il also charts in chapter 7), its impact factor (4% of Faculty of Biomedical Sciences of the Università Database, which will be made available on the premio, ma il piacere di utilizzare al meglio le all publications were in top-level scientific journals) della Svizzera Italiana. website www.eoc.ch by the end of 2015. capacità cognitive delle quali è dotato l'Homo and its number of clinical trials. Furthermore, the The EOC Official Registry is a very important tool to Sapiens) EOC is comparable, in number of publications Last but not least, such a growing development define strategies for further development in clinical (Rita Levi-Montalcini)”. and total impact factor, to other two important in scientific research is the best basis to ensure research of the EOC; besides, it will be essential to Cantonal Hospitals: Luzerner Kantonsspital (LUKS) that our patients increasingly receive updated and support the Human Medicine Master. and St. Gallen (KSSG). timely treatments, thanks to the prompt transfer Fabrizio Barazzoni MD MPH All this reflects the dedication and the excellence of the most recent knowledge from this sector to Finally, I wish to express my gratitude to all those FMH Prevention and Public Health Head of the Medical Area of the EOC Head Office of our scientists and clinical investigators, who patients. who contributed to a further growth in knowledge Chairman of the Scientific Research Advisory Board continue to receive high recognition at national produced by scientific research in the clinical field Bellinzona, 3rd July 2015 and international levels. However, special thanks In the various chapters included in this Scientific with great dedication, commitment and passion. should also go to the Clinical Trial Unit (CTU-EOC) Report, it is possible to follow, in more details, the This is because we are convinced that patients that promotes a culture of studies and favourable lines of research developed in the laboratories can be provided with a better healthcare quality conditions in the field of clinical research, assisting, and in all the clinical Services or Departments of in hospitals where research is actively carried out; for instance, in the process of grant writing and the EOC and to understand the deepest meaning our first goal remains to cure our patients. supporting educational programs for all those of their value. All major areas in medicine and involved in research. biology are actively developed and are covered by translational and clinical research projects.

6 Scientific Report 2014 Preface 7 1 Oncology Institute of Southern Switzerland (IOSI) 1. Oncology Institute of Southern Switzerland (IOSI)

The IOSI includes all the specializations dealing with (IOR) and are run by the "Fondazione ticinese per the success achieved in 2014 in more details. achieve this result in such a short period of time. oncology within the EOC in a single organizational la ricerca e la cura dei linfomi" (Ticino Foundation In this introduction I would just like to highlight However, in the field of research nothing is won structure. The IOSI has been devised on the basis for the research and treatment of lymphomas), the decision of our regional Parliament, which forever. Therefore, the achievement of this crucial of the North American model of "comprehensive although functionally, they are part of the IOSI’s at the end of last year, decided to create a new goal should not be viewed as the end point of our cancer centres", but has its own particular research division. Biomedical Department at USI (Università della journey it is rather, a happy beginning of a new era structure, as it has a horizontal structure Svizzera Italiana), which is our University. After of growth. throughout the EOC. IOSI and Research: Balance of a Year taking this decision, now the new department has Research has always been a pivotal priority for to be practically implemented. It will encompass Prof. Franco Cavalli MD Therefore the IOSI is intended to be an all-inclusive the IOSI. Our yearly research budget with more a Medical Master School (MMS), but will also Scientific Director structure, containing all the specializations that than 8 million CHF represents about 15% of the have a second sector (biomedical research), to deal with the diagnosis, treatment and research in total budget of IOSI, a proportion that almost no which our IOR should be affiliated even before the 1.1 Medical Oncology Service the field of tumour diseases. one among the other similar cancer institution in beginning of the activity of MMS. The procedure Prof. Michele Ghielmini MD Switzerland can reach. Functionally, the Research for this affiliation is already ongoing and should Medical Director of the IOSI and Head Doctor The IOSI has six Services: medical oncology, Division of IOSI encompasses both the clinical part be concluded in the course of this year. This will radio-oncology, haematology, nuclear medicine, as well as research, which is carried out in the represent not only the ultimate recognition of the It is well known, but worthwhile to be repeated palliative care and research. Each service has its laboratories of IOR. This ensures that the clinical quality of the research activities we have been continuously, that patients are much better treated own research program coordinated by the the part and the laboratory research are closely carrying out in the last few years, but will also in health structures where research is carried IOSI Scientific Board, which decides on common connected, which is still something that many mean this is a guarantee for the long-term stability out. Indeed, the physician, who spends some of his research guidelines. The research laboratories cancer institutes in Switzerland do not have. of IOR. When we started to develop our research working time (and very often also of his free time!) of the Institute for Research in Biomedicine (IRB) I will tackle this subject later on, when I present laboratories a little over 10 years ago, we would to deal with clinical studies and research is obliged are part of the Institute of Oncology Research the activity of the research division of the IOSI, never have dreamed of being able to not only to be very updated, but also to predict the future developments in his field.

10 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 11 Research is absolutely necessary to become a without this assessment (Dr. Ratti and Dr. Marini). The scientific activities of the Radiation-Oncology doses and fractionation schedules for ductal specialist in a specific disease within oncology. Department, with the contribution of the carcinoma in situ (DCIS) of the breast. At the IOSI there are always more organised Main funding physicians and a research nurse/data manager, Lead investigator IOSI: MC. Valli. disease-oriented structures, in which physicians, The above mentioned activities are financed by are aimed at participating in multicentric Swiss Sub-investigators: A. Richetti, P. Pittoni. who are particularly interested in one neoplastic SAKK (Swiss Group for Clinical Cancer Research), and international clinical studies, in the following disease, try, - very often in a multidisciplinary by the ABREOC (hospital competitive grant), by clinical fields: Women with completely excised non-low risk way - to ensure the highest possible treatment our own scientific foundation, by the scientific ductal carcinoma in situ (DCIS) treated by quality to their patients. This entails collaborations foundations of the departments with which we 1. Breast cancer: breast conserving surgery suitable for adjuvant in national and international studies and a perform the trials. whole breast radiation therapy (RT) are eligible close cooperation with the research activities • IRMA: breast cancer with low risk of local for the study. Women will be randomised to developed by our colleagues, who work in the Peer reviewed publications in 2014 (selection) recurrence: partial and accelerated irradiation receive one of the following two treatments: laboratory field (IOR). A continuous and fruitful Dreyling M, Ghielmini M, Marcus R, Salles G, Vitolo U, with three-dimensional conformal radiotherapy Arm 1: Whole breast RT alone using standard cooperation, between clinitians and basic as well Ladetto M; ESMO Guidelines Working Group. Newly (3DCRT) vs. standard radiotherapy after fractionation (50 Gy / 25 fractions, 5 per as translational researchers, has always been one diagnosed and relapsed follicular lymphoma: ESMO conserving surgery (phase III study). week) Arm 3: Whole breast RT using standard of the focuses of the activities of the IOSI. This is Clinical Practice Guidelines for diagnosis, treatment Lead investigator IOSI: MC. Valli. fractionation (50 Gy / 25 fractions, 5 per week) increasingly becoming more apparent every year and follow-up. Ann Oncol. 2014;25 Suppl 3:iii76-82. Sub-investigators: A. Richetti, P. Pittoni. plus tumour bed boost (16 Gy / 8 fractions, also considering the plans for the establishments 5 per week). Primary objective: to individualise of a Medical Faculty. Froesch P, Martucci F, Györik S, Dutly AE, Cafarotti Conservative surgery (including large breast treatment selection for women with DCIS S. Management of non-small cell lung cancer in the resection and lumpectomy + biopsy of the following breast conserving surgery to achieve Main areas of research elderly. Eur J Intern Med. 2014;25(10):888-894. sentinel lymph node and/or axillary dissection) long term disease control with minimal toxicity. The main in clinical research activity of the medical followed by post-op RT: Trial arm 38.5 Gy total Total number of randomized pts: 1608, IOSI/ oncology department is the participation to Nabhan C, Ollberding NJ, Villines D, Chiu BC, Caces in 10 fractions (3.85 Gy per fraction), twice a RT: 5 pts, study closed for accrual on 22 June multicenter national trials of the Swiss Group for DB, Valdez TV, Ghielmini M, Hsu Schmitz SF, Smith day with an interval of at least 6 hours between 2014, follow-up still on going. Clinical Research (SAKK). Here we include 50 to SM. A systematic review of comparative schedule- the two fractions, for five consecutive working 60 patients every year, mainly in the fields of breast related toxicities with maintenance rituximab days. Control arm 45 Gy/18 fractions, or 50 2. Neuro-Oncology cancer: cancer, gastrointestinal cancer and lymphoma. in follicular and mantle cell lymphomas. Leuk Gy/25 fractions, or 50,4 Gy/28 fractions, or We also strictly collaborate with the research of Lymphoma. 2014;55(6):1288-94. isoeffective fraction schemes, once a day for • CDX110-04, ACT IV: an international, the lymphoma unit, of the breast unit and of the 5 days a week. A 10 - 16 Gy boost is allowed randomized, double blind, controlled study drug development unit of the IOSI with which we Pittoni P, Di Lascio S, Conti-Beltraminelli M, Valli in centres where it is part of the standard of Rindopepimut/GM-CSF with adjuvant share a number of projects. MC, Espeli V, Bongiovanni M, Richetti A, Pagani O. treatment. Primary Objectives: the main aim Temozolomide in patients with newly Paranasal sinus metastasis of breast cancer. BMJ of the study is to evaluate whether partial hypo diagnosed, surgically resected, EGFRvIII-positive A fruitfull collaboration is established with the Case Rep. 2014;2014. fractionated and accelerated irradiation of the glioblastoma (the ACT IV study). Canton’s Institute of Pathology, particularly the sole surgical cavity, in patients suffering from Lead investigator IOSI: GF. Pesce. molecular biology lab of Dr. Frattini, with which we Wannesson L, Viteri S, Costa C, Karachaliou breast cancer with low risk of local recurrence Sub investigator: NC. Azinwi. conduct studies on molecular markers that are N, Molina-Vila MA, Rosell R. Signaling pathways and undergoing conservative surgery, is not predictive for response to therapy in colorectal modulating dependence of lung cancer on mutant lower than postoperative irradiation with This is an international, multicenter, double- and gastric cancer (Dr. Saletti and Dr. De Dosso), epidermal growth factor receptor and mechanisms conventional fractionation of the entire breast blind clinical trial of rindopepimut in which and on the receptor tyrosine kinase expression in of intrinsic and acquired resistance to tyrosine kinase as regards local control, measured in terms approximately 700 patients with newly lung cancer biopsies (Dr. Wannesson). inhibitors. Curr Pharm Des. 2014;20(24):3883- of incidence of ipsilateral recurrences as first diagnosed, resected, EGFRvIII positive 3893. event. glioblastoma will, after completion of standard Another study is running in the field of geriatric Total number of randomized pts: 2081, IOSI/ chemoradiation, be randomized to receive oncology: patients above the age of 70 are classified 1.2 Radiation Oncology Service RT: 73 pts. either rindopepimut/GM-CSF or control as fit, frail or vulnerable, and the treatment is Antonella Richetti MD (KLH), in combination with standard adjuvant determined according to specific guidelines. Their Head Doctor • IBCSG 38-10 / BIG 3-07 / TROG 07.01: temozolomide. The primary objective of outcome will be compared to patients treated Main areas of research a randomized phase III study of radiation the study is to confirm that the addition

12 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 13 of rindopepimut/GM-CSF to adjuvant • EORTC 26082-22081: radiation therapy AUC 7 on day 1 of trial treatment, followed 3 Sub investigator: F. Martucci. temozolomide improves overall survival in and concurrent plus adjuvant Temsirolimus weeks later by 15 x 2 Gy (stage IIA) or 18 x All eligible patients will be randomised between patients with newly diagnosed EGFRvIII positive (CCI-779) versus chemo-irradiation with 2 Gy (stage IIB) small volume, involved node thoracic adjuvant conformal radiotherapy at glioblastoma who have undergone gross-total temozolomide in newly diagnosed glioblastoma radiation therapy. The main objective of this trial the dose of 54 Gy/27 to 30 fractions and resection. without methylation of the MGMT gene is to test the efficacy and safety of carboplatin no thoracic adjuvant radiotherapy. Primary Total number of randomized pts: 700, in CH: 16, promoter – a randomized multicenter, open- chemotherapy and involved node radiotherapy objective: improvement of disease-free survival study closed for accrual on 19 September 2014. label, Phase II study. in patients with stage IIA/B seminoma. (DFS) by conformal thoracic radiotherapy Lead investigator IOSI and Trial chair: GF. Pesce. Total number of randomized pts: 31, IOSI/RT: compared to no radiotherapy. • IOSI-RTO-001: stereotactic hypo fractionated 0 pts. Total number of randomized pts: 284, IOSI/ radiotherapy or radiosurgery of the resection Recent data demonstrated a better survival in RT: 0 pts. cavity after surgical removal of solid tumour patients treated for glioblastoma with standard • SAKK 09/10: dose intensified salvage brain metastases. Radiotherapy and temozolomide, if they have radiotherapy in biochemically relapsed • SAKK 15/12: early prophylactic cranial Lead investigator and Trial chair: GF. Pesce. methylated MGMT promoter gene. The current prostate cancer without macroscopic disease. irradiation with hippocampal avoidance in Sub investigator: NC. Azinwi. trial aim is to explore a new treatment option A randomized phase III trial. patients wit limited disease small-cell lung for patients with unfavourable glioblastoma Lead investigator IOSI: GF. Pesce. cancer, a multicenter phase II trial. Patients with brain metastases from solid subpopulation with unmethylated MGMT Sub investigator: NC. Azinwi. Lead investigator IOSI: GF. Pesce. tumours (lung, breast, kidney, melanoma, promoter methylation. Sub investigator: F. Martucci. colorectal) in good general condition and Total number of randomized pts: 257. Study Megavoltage equipments with nominal controlled systemic disease will be irradiated closed for accrual in 2013, follow-up still on going. photon energies ≥ 6 MV are required. Trial treatment consist in HA-PCI concomitant to the resection cavity with 18 Gy in single Rotational techniques such as Tomotherapy®, to the second cycle of chemotherapy and to fraction or 5-7 Gy with 5 consecutive daily 3. Urogenital cancer: Rapidarc®, intensity-modulated arc technique radiotherapy. The HA-PCI regimen consists fractions. The aim of the study is to investigate and volumetric-modulated arc therapy will also of a total dose of 25 Gy (2.5 Gy / fraction / the role of focused high dose irradiation to • EORTC 22043-30041: immediate or early be eligible. The patient will be treated in an 5XW) for 2 weeks. Cisplatin or Carboplatin and reduce the risk of local relapse after resection salvage post-operative external radiotherapy isocentric setting and all fields will be applied Etoposide will be administered for 4 to 6 cycles of brain metastases, while avoiding whole brain combined with concomitant and adjuvant for 5 days per week for the total RT duration. according to local standards. Radiotherapy radiotherapy and the related toxicity. hormonal treatment versus immediate RT in the standard arm A will be administered consists either of 45 Gy (1.5 Gy / fraction Study will be open for accrual in January 2015. or early salvage post-operative external to a total dose of 64 Gy in 32 fractions of 2 Gy / BID / 5XW) for 3 weeks or 60 Gy (2 Gy radiotherapy alone in pT3a-b R0-1 cN0M0 / over 6.4 weeks. RT in the experimental arm B / fraction / 5XW) for 6 weeks according to • EORTC 22033-26033: primary chemotherapy pT2 R1 cN0M0, Gleason score 5-10 prostatic will be administered to a total dose of 70 Gy local standards. Primary objective: to assess with Temozolomide vs radiotherapy in patients carcinoma. A phase III study. in 35 fractions of 2 Gy over 7 weeks. Primary neurocognitive function after early hippocampal with low grade gliomas after stratification for Lead investigator IOSI: GF. Pesce. objective: Assessment of tumour control, avoidance prophylactic cranial irradiation. genetic 1p loss: a phase III study. Sub investigator: NC. Azinwi. toxicity and quality of life (QoL) after dose Total number of randomized pts: 4, IOSI/RT: 0 Lead investigator IOSI: GF. Pesce. intensified salvage radiotherapy (RT). pts. Sub investigator: NC. Azinwi. Total number of randomized pts: 86, IOSI/RT: Total number of randomized pts: 350, IOSI/RT: 2 pts. Premature study closure due to poor 12 pts. Study closed for accrual on 01 April 5. Head and neck cancer: Patients will be treated with Radiotherapy 50.4 recruitment, follow-up still on going. 2014, follow-up on going. Gy in 28 fractions x 1.8 Gy or Temozolomide • INT 48/14: health and economic outcomes of 75 mg/m2 daily x 21 days, q 28 days until • SAKK 01/10: Carboplatin chemotherapy 4. Lung cancer: two different follow up strategies in effectively progression or for max. 12 cycles. The aim and involved node radiotherapy in stage IIA/B cured advanced head and neck cancer. A of the study is to demonstrate a difference seminoma. • EORTC 22055-08053: phase III study phase II trial. in progression-free survival for primary Lead investigator IOSI: GF. Pesce. comparing post-operative conformal Lead investigator IOSI: A. Richetti. treatment. Sub investigator: NC. Azinwi. radiotherapy to no post-operative radiotherapy Sub investigator: F. Martucci. Total number of randomized pts: 700, IOSI/RT: with completely resected non-small cell lung 4 pts. Study closed for accrual, follow-up still on Within 13 weeks after orchiectomy, the cancer and mediastinal N2 involvement. Patients deemed to be in complete remission going. patients will receive one infusion of carboplatin Lead investigator IOSI: A. Richetti. at month 6 (+/- 1 month) after curative

14 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 15 treatment will be randomized in two follow-up continued to follow its research projects. The phase space files. cancer. Radiat Oncol. 2014 Oct 28;9(1):236. arms: Arm A, non-intensive, follow-up according collaboration with international groups was Scorsetti M, Alongi F, Clerici E, Comito T, Fogliata to NCCN guidelines with CT scan or MRI only pursued also in the course of 2014; the main • Evaluation of dose distributions in patients A, Iftode C, Mancosu P, Navarria P, Reggiori on the occurrence of new signs or symptoms institutions include: Istituto Clinico Humanitas treated with the RapidArc technology G, Tomatis S, Villa E, Cozzi L. Stereotactic body versus Arm B, intensive, as arm A but with CT of Milan in Italy, Cheng-Ching General Hospital of (volumetric modulated arc therapy VMAT) radiotherapy with flattening filter-free beams scans, MRI or PET scans at fixed time points Taichung in Taiwan, Kaiser-Franz-Josef Spital of in different anatomical sites, compared with for prostate cancer: assessment of patient- according to the type of tumour, smoking Vienna in Austria, CRLC Val d'Aurelle of Montpellier other techniques. reported quality of life. J Cancer Res Clin Oncol. history and age. To both arms, QoL forms and Institut Sainte Catherine of Avignon in 2014;140(10):1795-800. and socio-economic questionnaires will be France, centres of Istanbul in Turkey, Universitat • Use of amorphous silicon detectors in quality administered. Politécnica de Catalunya of Barcelona in Spain, assurance procedures for different treatment Tozzi A, Cozzi L, Iftode C, Ascolese A, Campisi Total number of randomized pts: 11, IOSI/RT: Universitätsklinikum of Essen in Germany. techniques and different beams. MC, Clerici E, Comito T, De Rose F, Fogliata A, 0 pts. The research projects at the Medical Physics Unit The ongoing study on the dose released to the Franzese C, Mancosu P, Navarria P, Tomatis S, Study is send to the Ethics Committee in followed the main fields of the research strategy patient during the radiation treatment with the Villa E, Scorsetti M. Radiation therapy of anal canal December 2014 and will start at the beginning of the group: the dose calculation algorithms and acquisition of such images is continuing. cancer: from conformal therapy to volumetric of 2015. the dose optimization algorithms, with particular modulated arc therapy. BMC Cancer. 2014 Nov attention to the new optimization algorithms based Main funding 18;14:833. Main funding on the knowledge based concept, for which the No financing. SAKK (SAKK 01/10, SAKK 09/10, SAKK two first publications on the so-called RapidPlan 1.4 Nuclear Medicine Service and PET/CT 15/12, IBCSG 38-10), ABREOC (IOSI-RTO-001), approach came from the IOSI Medical Physics Peer-reviewed publications in 2014 (selection) Centre Celldex Therapeutics, Inc (CDX110-04), European group. Another interesting item is the flattening Belosi MF, Rodriguez M, Fogliata A, Cozzi L, Luca Giovanella MD PD Organisation for Research and Treatment of filter free (FFF) beams as a fundamental physics Sempau J, Clivio A, Nicolini G, Vanetti E, Krauss Head Doctor Cancer, EORTC (EORTC 22033), other study approach, also using Monte Carlo simulations, H, Khamphan C, Fenoglietto P, Puxeu J, Fedele D, EORTC; INT 48/14 and study IRMA no funding. as well as its clinical application. The application Mancosu P, Brualla L. Monte Carlo simulation of Nuclear medicine employs substances emitting of the new technologies to stereotactic body TrueBeam flattening-filter-free beams using varian low radiation level (radiopharmaceuticals) Peer reviewed publications in 2014 radiotherapy (SBRT) is more clinically oriented. phase-space files: comparison with experimental and technologically very advanced equipment Froesch P, Martucci F, Györik S, Dutly AE, Cafarotti data. Med Phys. 2014 May;41(5):051707. (gamma cameras, SPET/CT and PET/CT S. Management of non-small cell lung cancer in the In particular, in 2014 the activities were mainly on tomographs) to carry out diagnostic tests elderly. Eur J Intern Med. 2014;25(10):888-894. the following topics: Clivio A, Belosi MF, Cozzi L, Nicolini G, Vanetti E, (scintigraphy, tomoscintigraphy, SPECT/CT and Bolard G, Fenoglietto P, Krauss H, Fogliata A. On PET/CT) in every medicine branch. Moreover, Pittoni P, Di Lascio S, Conti-Beltraminelli M, Valli • Evaluation and assessment of the possible and the determination of reference levels for quality some radiopharmaceuticals are used for the MC, Espeli V, Bongiovanni M, Richetti A, Pagani O. feasible clinical application of the knowledge- assurance of flattening filter free photon beams in treatment of hyperthyroidism and goitre, thyroid Paranasal sinus metastasis of breast cancer. BMJ based treatment planning concept. radiation therapy. Med Phys. 2014;41(2):021713. carcinomas, bone metastases, some lymphomas Case Rep. 2014;2014. pii: bcr2014205171. doi: The group worked during the evaluation phase and inflammatory arthropathy. 10.1136/bcr-2014-205171. of the RapidPlan engine helping in driving Fogliata A, Belosi F, Clivio A, Navarria P, Nicolini The Service is located in the Regional Hospital of the evolution of the system into the widest G, Scorsetti M, Vanetti E, Cozzi L. On the Bellinzona and Valli (San Giovanni) and the Regional 1.3 Medical Physics Unit of the Radiation radiotherapy clinical application field. pre-clinical validation of a commercial model- Hospital of Lugano (Civico). In both hospitals, all Oncology Service based optimisation engine: Application to nuclear medicine diagnostic tests, including PET/ Fogliata Antonella MSc SSRMP/SGSMP • Evaluation and research in the flattening filter volumetric modulated arc therapy for patients CT, iodine-131 treatments (outpatients), intra- Medical Physicist free (FFF) beams field. with lung or prostate cancer. Radiother Oncol. articular radiosynoviorthesis and treatments for Unit Head This project evaluated the benefit of using these 2014;113(3):385-391. bone metastases are carried out. The Centre photon beams on different anatomical sites for in-patient iodine-131 treatments and other Main areas of research and pathologies. Both dosimetric and clinical Fogliata A, Wang PM, Belosi F, Clivio A, Nicolini G, radioisotopic therapies is located at the San In 2014 the Medical Physics Unit of the processes were analysed. A huge work, in Vanetti E, Cozzi L. Assessment of a model based Giovanni hospital (3 dedicated rooms). The Radiotherapy Dept, also thanks to the scientific physics of the FFF beams, was carried out with optimization engine for volumetric modulated arc Service includes the EOC Integrated Centre for advisory and coordination of Dr. Luca Cozzi, Monte Carlo simulations validating predefined therapy for patients with advanced hepatocellular Thyroid Diseases: “one-stop-shop” specialized

16 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 17 consultations, including diagnostic procedures (US, follow-up of differentiated thyroid carcinoma. • BAYER 88-223/16298. and Periapproval Services Ltd, GE Diagnostics, scintigraphy, fine-needle and core-needle biopsy) Lead investigator: L. Giovanella. Lead investigators: O. Pagani, G. Paone. Genzyme-Sanofi, Ibsen AB, IELSG (International and non-surgical therapies (drugs, radioiodine, US- A phase 2 randomized double-blind placebo Extranodal Lymphoma Study Group), Medeo guided alcohol injection), are provided and the EOC • Role of FDG-PET/CT in the differential diagnosis controlled trial of Radium-223 dichloride vs. Diagnostics, Mallinkrodt-Covidien, Oncosuisse, Multidisciplinary Thyroid Board is coordinated. of thyroid nodules with indeterminate cytology. placebo when administered to metastatic Roche Diagnostics, SAKK. Several types of collaboration are underway Lead investigator: L. Giovanella. HER2 negative hormone receptor positive concerning both teaching and research, breast cancer with bone metastases treated Peer reviewed publications in 2014 (selection) mainly in the fields of thyroid diseases, PET/ • Quantitative ultrasonography analysis of thyroid with hormonal treatment. Bertagna F, Giubbini R, Treglia G. Positron emission CT evaluation of lymphomas, nuclear cardiology, nodules and surrounding tissues. tomography/computed tomography for diagnosis radiopharmaceutical therapies and meta-analysis Lead investigator: L. Giovanella. • BAYER 88-223/17096. of prosthetic valve endocarditis: suggestions to and cost-effectiveness studies in nuclear medicine Lead investigators: O. Pagani, G. Paone. increase diagnostic accuracy. J Am Coll Cardiol. and endocrinology (in collaboration with the 2. Oncology: 2014;63(4):378-379. Universities of Zurich, Aachen, Marburg, Leiden, A phase 2 randomized double-blind placebo- Birmingham, Mashhad, Rome, Brescia and Pavia, • IELSG 37 study. controlled trial of Radium-223 dichloride vs. Giovanella L, Treglia G, Sadeghi R, Trimboli the National Cancer Centre in Milan and the Mayo Lead investigators: L. Ceriani, E. Zucca. placebo when administered to metastatic P, Ceriani L, Verburg FA. Unstimulated highly Clinic). HER2 negative hormone receptor positive sensitive thyroglobulin in follow-up of differentiated A randomized multicenter phase 3 comparative breast cancer with bone metastases treated thyroid cancer patients: a meta-analysis. J Clin Main areas of research study assessing the role of involved mediastinal with the standard treatment exemestane and Endocrinol Metab. 2014;99(2):440-447. 1. Thyroid disorders: radiotherapy after Rituximab containing everolimus. chemotherapy regimens to patients with Heinzel A, Müller D, Behrendt FF, Giovanella • Role of Tc99m-sestaMIBI in the differential Primary Mediastinal Large B-Cell Lymphoma. • Health and economic outcomes of two L, Mottaghy FM, Verburg FA. Thyroid nodules diagnosis of follicular thyroid nodules. different follow-up strategies in effectively with indeterminate cytology: molecular imaging Lead investigator: L. Giovanella. • GHSG HD17. cured advanced Head and Neck cancer. with 99mTc-methoxyisobutylisonitrile (MIBI) Lead investigators: L. Ceriani, E. Zucca. Lead investigators: L. Licitra, A. Richetti, G. is more cost-effective than the Afirma gene • Role of 18FDG-PET/CT in patients with Paone. expression classifier. Eur J Nucl Med Mol Imaging. advanced thyroid cancer. A trial designed to determine whether 2014;41(8):1497-1500. Lead investigator: L. Giovanella. radiotherapy can possibly be omitted in low-risk 3. Cardiology: patients after chemotherapy. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri • Individual dosimetry in radiometabolic therapy. • ANMCO ISCHEMIA. AJ, Vitolo U, Stelitano C, Brusamolino E, Cabras Lead investigator: L. Giovanella. • GHSG HD18. Lead investigators: T. Moccetti, L. Ceriani MG, Rigacci L, Balzarotti M, Salvi F, Montoto S, Lead investigators: L. Ceriani, E. Zucca. Lopez-Guillermo A, Finolezzi E, Pileri SA, Davies • Evaluation of serum parathyroid hormone- A multinational randomized clinical trial with A, Cavalli F, Giovanella L, Johnson PW. [18F] related peptide in hyperthyroid patients. A study designed to individualize treatment the aim of comparing the optimal medical fluorodeoxyglucose positron emission tomography Lead investigator: L. Giovanella. according to early response to chemotherapy. treatment versus an interventional strategy predicts survival after chemoimmunotherapy added to the optimal medical treatment in for primary mediastinal large B-cell lymphoma: • Relationship between serum calcitonin levels • BELLE-CBKM120F2302. patients with mild-severe ischemia. results of the International Extranodal Lymphoma and thyroid volume in healthy subjects. Lead investigators: O. Pagani, L. Ceriani. Study Group IELSG-26 Study. J Clin Oncol. Lead investigator: L. Giovanella. 4. Health Technology Assessment (HTA) and 2014;32(17):1769-1775. A phase 3 randomized double blind clinical Evidence-Based Medicine: • Elastosonography and molecular markers on trial with BKM120 or placebo combined with Piccardo A, Puntoni M, Bertagna F, Treglia G, fine needle aspiration biopsy in the differential fulvestrant in postmenopausal patients with • A meta-analysis on PET/CT in oncology. Foppiani L, Arecco F, Giubbini R, Naseri M, Cistaro diagnosis of thyroid nodules with indeterminate breast carcinoma and positive hormonal Lead investigator: G. Treglia. A, Cabria M, Bardesono F, Ceriani L, Orlandi F, cytology. receptor HER2-negative, locally advanced Giovanella L. F-FDG uptake as a prognostic variable Lead investigator: L. Giovanella. or metastatic cancer, in progression after Main funding in primary differentiated thyroid cancer incidentally • A new high-sensitive thyroglobulin assay in the treatment with aromatase inhibitors. ABREOC, Brahms-Termofisher, Covance Clinical detected by PET/CT: a multicenter study. Eur J

18 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 19 Nucl Med Mol Imaging. 2014;41(8):1482-1491. The main research projects are: perception of doctors and nurses as regards In 2014, a major step for the development of Treglia G, Giovanella L, Lococo F. Evolving role of • Participer à un suicide assisté: étude the quality of the care provided before death. the division of haematology was made by the PET/CT with different tracers in the evaluation of exploratoire sur l’expérience des proches et Currently, data analysis is in progress. integration of the complete haematology laboratory pulmonary neuroendocrine tumours. Eur J Nucl leurs représentations de la fin de vie, de la mort in EOLAB under the lead of PD Dr. med. Georg Med Mol Imaging. 2014;41(5):853-855. et du deuil. • Meaning of life, personal values and spirituality Stüssi. This step completed the diagnostic chain Lead investigator: C. Gamondi. at the end of life. for haematology by opening new avenues both 1.5 Palliative Care Service Lead investigator: G. Borasio (CHUV). for clinical routine and for clinical and laboratory Claudia Gamondi MD, MSC This is a three-year open multicenter qualitative research projects. Clinical Director study (phase II) aimed at describing the charac- This is an 18-month, mixed prospective study In collaboration with the SAKK, the division of teristics of the mourning of relatives of patients aimed at studying the connection between haematology has been involved in the development Palliative care involves looking after a patient with who die through assisted suicide. Currently, the people questioning themselves as to the of several clinical protocols. Most importantly, a life-threatening illness and his family adopting final publication is in progress. meaning of life and spirituality at the end of phase II protocol for patients with myeloproliferative a global approach aimed at maintaining or re- their lives in an end-of-life context. Currently, neoplasias was finished, and the patient accrual establishing the best possible quality of life through • An interview Study on Swiss palliative care data analysis is in progress. should start in early 2015. Moreover, in 2014, an interdisciplinary team with highly specialized physicians’ opinions concerning hastened the base for a Swiss-wide database for registering skills. The mission of Palliative Care Service (SCP death practices. Main funding patients with myelodysplastic syndromes was - Servizio di Cure Palliative), which is available at Lead investigator: C. Gamondi. “An interview Study on Swiss palliative care made. Given the increasing age of the population all the EOC hospitals, is to promote this philosophy physicians’ opinions concerning hastened death and the recent therapeutic developments, the and to disseminate the specific know-how of This is a three-year open multicenter qualitative practices”: Swiss Cancer Research (external myelodysplastic syndrome is gaining importance. palliative care to hospital teams through specialist This project seeks to describe Swiss palliative competitive grant, starting: 2014, duration: 1 This registry provides the opportunity to perform consultation at the patient’s bedside and by care experts’ perspectives on assisted suicide, year). studies within Switzerland and in collaboration developing the necessary training programs. considering that this is a highly controversial with international study groups. The treatment The Palliative Care Unit (UCP - Unità di Cure issue, discussed in literature and by the public “FIT (Fine Vita Ticino – “End of life Ticino”) study. of patients with myelodysplastic syndromes has Palliative) is equipped with seven beds and a opinion. The primary purpose of this study Epidemiology of death in Ticino’s public hospitals”: so far not been the subject of clinical studies in specialist team as part of the IOSI’s inpatient units is to investigate and highlight controversies ABREOC (hospital competitive grant). Switzerland. In 2014, a collaboration with the at Regional Hospital of Bellinzona and Valli (San concerning assisted suicide in itself and its HOVON group was established for the development Giovanni). The unit is designed to offer relief from possible legalization. It is a qualitative study, “Meaning of life, personal values and spirituality at of an international study protocol for low-risk MDS suffering in unstable, complex situations. using open interviews to 15-20 palliative care the end of life”: Swiss National Science Foundation patients. physicians recruited from the three different (SNSF) (external competitive grant, duration: The SAKK leukemia project group has a long track The IOSI’s palliative care service is a highly linguistic regions. It will be a one year project. 2012-2014). in studies with hairy cell leukemias and has been advanced model, labelled "Designated Centre of Currently, it is in data collection phase. among the first ones to show the feasibility of Integrated Oncology and Palliative Care” (ESMO Other research funds: Fondazione Hospice subcutaneous treatment with cladribine. However, 2004-2016). The palliative care unit has been • FIT (Fine Vita Ticino – “End of life Ticino”) (external non-competitive grant, duration: 1 year, given the fact that patients with hairy cell leukemia awarded with the label "Quality in Palliative Care". study. Epidemiology of death in Ticino’s public starting: 2014); Fondazione Realini (external non- survive for several decades after treatment, long- hospitals. competitive grant, starting: 2013). term effects of this treatment are of importance. The research unit is composed of physicians, a Lead investigator: C. Gamondi. In 2014, the SAKK LPG therefore developed nurse, a research coordinator and boasts national Peer reviewed publications in 2014 retrospective data collection of late effects of and international collaborations. Its main partners This is a one-year observational prospective Gamondi C, Borasio GD, Limoni C, Preston N, Payne the treatment in patients with hairy cell leukemia include: IOSI Oncology Department, SUPSI, Haute study with the following purposes: describing S. Legalisation of assisted suicide: a safeguard to treated within previous study trials. École Santé Lausanne, Service de Soins Palliatifs how adult patients die in public hospitals euthanasia? Lancet. 2014;384:127. (CHUV Lausanne), Onkölogische Palliativmedizin in Ticino and, in particular, how they are Main areas of research in St. Gallen and the International Observatory for assisted as they approach death; identifying 1.6 Haematology Service • Clinical research into acute myeloid leukemia in End of Life Care (Lancaster, UK). any differences in the treatment of patients Georg Stüssi MD PD elderly patients. whose death is expected compared to those Head Doctor Lead investigators: G. Ossenkoppele, B. Main areas of research whose death is not expected; assessing the Löwenberg, G. Stüssi.

20 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 21 The HOVON 103 trial was activated in 2011 nestin+ MSCs triggered by the mutant HSCs. haematopoietic SCT and the general population: a which defines a new standard in the adjuvant introducing a novel trial design to SAKK studies. In vivo depletion of nestin+ cells accelerated matched control study. Bone Marrow Transplant. endocrine treatment of operable breast cancer. It is a randomized phase II study in elderly AML MPN progression. Conversely, MPN phenotype 2014;49(9):1223-1230. And last but not least, the two papers published in patients with multiple parallel experimental could be reversed by compensating for the the same issue of the Journal of Clinical Oncology, arms, which are all compared to a common sympathetic neuropathy using the treatment Marek A, Stern M, Chalandon Y, Ansari M, Ozsahin both coordinated by PD Dr. Emanuele Zucca. Both standard arm. The first experimental arm was with a beta-3-sympathicomimetic drug. Mice H, Güngör T, Gerber B, Kühne T, Passweg JR, articles summarize the conclusion of a working lenalidomide, and the accrual in Switzerland with JAK2-V617F driven MPN treated with Gratwohl A, Tichelli A, Seger R, Schanz U, Halter J, group, started at the International Conference on was very good. After long discussions about a beta-3-sympathicomimetic agonist not Stussi G; Swiss Blood Stem Cell Transplantation. Malignant Lymphoma (ICML) in Lugano in 2011, the design of the trial, the new study drug was only restored nestin+ MSCs numbers, but The impact of T-cell depletion techniques on the that redefined the role of PET in the management finally approved by the Swiss authorities and also showed correction of thrombocytosis, outcome after haploidentical hematopoietic SCT. of malignant lymphomas and presented the so- should start within the next weeks. Moreover, neutrophilia, and bone marrow fibrosis, and Bone Marrow Transplant. 2014;49(1):55-61. called “Classification of Lugano”, defining a new a protocol for a third study drug was developed efficiently reduced mutant hematopoietic way of staging malignant lymphomas. looking at a new class of drugs (selective progenitor numbers in bone marrow and Passweg JR, Pabst T, Blum S, Bargetzi M, Li Q, inhibitors of nuclear export). These drugs block peripheral blood. Thus, treatments with a beta- Heim D, Stussi G, Gregor M, Leoncini L, Meyer- Research activities are increasingly attracting the export of several tumour-suppressor and 3 sympathicomimetic agonist corrected the Monard S, Brauchli P, Chalandon Y; Swiss Group young and extremely talented researchers. In cell-cycle regulatory proteins from the nucleus damage inflicted by the MPN clone on the stem for Clinical Cancer Research (SAKK). Azacytidine for 2014 a new research group was added at IOR; thereby increasing the effective cell-cycle and cell niche and led to a dramatic improvement acute myeloid leukemia in elderly or frail patients: this group is managed by Dr. Jean-Philippe tumour-regulation within a tumour cells. First of the MPN phenotype. Therefore, beta-3 a phase II trial (SAKK 30/07). Leuk Lymphoma. Theurillat, who came to IOR from the MIT in Boston clinical data are encouraging, and the trial sympathicomimetic agonists represent a 2014;55(1):87-91. with a Young Professorship Grant from the Swiss should hopefully open in 2015. promising novel therapeutic approach to MPN National Fund for Research. Another group, dealing by targeting the stem cell niche rather than 1.7 Research Division with the biology of chronic lymphocytic leukemia • Effects of sympathicomimetic agonists on the the MPN clone itself. Considering the widely Prof. Franco Cavalli MD (CLL), will be added at the end of 2015. Because disease course and mutant allele burden in used and established safety track record of Scientific Director of the logistic problems occurring in the current patients with JAK2-mutated myeloproliferative beta-3-sympathicomimetic drugs, a phase II building, we look forward to the construction of the neoplasms- A multicenter phase II trial. study has been selected to test the concept of From an operational point of view, the IOSI new research building in Bellinzona. Lead investigators: R. Skoda, J. Passweg, G. a beneficial effect of beta sympathicomimetic Research Division encompasses both the sector Stüssi. activity on bone marrow niche cells and through of clinical investigations as well as the experimental From an operational point of view, the IOSI clinical this effect on the disease manifestation in MPN laboratories at IOR (Institute of Oncology Research). research is mainly divided into five units: MPN is initiated and maintained by a patients. In order to optimize the collaboration among all mutated hematopoietic stem cell (HSC). The those involved in research, a Scientific Board of the • New Drug Development Unit, under the interplay between the MPN HSCs and the Peer reviewed publications in 2014 IOSI was established, where all 6 divisions of the direction of Prof. Cristiana Sessa MD. stem cell niche is increasingly recognized as Benz R, Schanz U, Maggiorini M, Seebach JD, IOSI, as well as IOR, are represented. This Scientific crucial for the biology of the disease. It was Stussi G. Risk factors for ICU admission and ICU Board meets 4-5 times a year. In 2014, there was • Lymphoma Unit, coordinated by Emanuele previously demonstrated that nestin-positive survival after allogeneic hematopoietic SCT. Bone a further strengthening of the structure of the Zucca MD PD. mesenchymal stem cells (nestin+ MSCs) Marrow Transplant. 2014;49(1):62-65. Clinical Trial Unit of the EOC (CTU-EOC), which is within the bone marrow niche are innervated mainly managed within the IOSI in Bellinzona. Last • Breast Unit, coordinated by Olivia Pagani MD. by sympathetic nerve fibers and are important Berger MD, Meisel A, Andres M, Schanz U, year was particularly positive as regards relevant • Gastrointestinal Cancer Group, coordinated by in regulating normal HSC. New findings by Dr. Schwarz U, Stussi G. Unusual case of progressive publications. Some of the most significant ones Piercarlo Saletti MD. Méndez-Ferrer’s laboratory show that these multifocal leukoencephalopathy after allogeneic are underlined below. First of all, the paper by Dr. • Prostate Cancer Unit, coordinated by Enrico nestin+ MSCs are strongly reduced in bone hematopoietic stem-cell transplantation. J Clin Alimonti’s group published in Nature, where they Roggero, MD. marrow from patients with MPN. Furthermore, Oncol. 2014;32(9):e33-34. present a discovery that could significantly change in a mouse model of MPN expressing the the therapeutic perspectives in the treatment of 1.7.1 New Drug Development Unit human JAK2-V617F mutation, this effect Kirsch M, Götz A, Halter JP, Schanz U, Stussi prostate cancer. However, please also note the Prof. Cristiana Sessa MD was found to be caused by early glial and G, Dobbels F, De Geest S. Differences in health paper published in the New England Journal of Deputy Head Doctor at the IOSI sympathetic nerve damage and apoptosis of behaviour between recipients of allogeneic Medicine whose first author is Dr. Olivia Pagani,

22 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 23 Main areas of research 2014;32(6):1188-96. • OSI-LND-001: A Phase I study of Inotuzumab • IELSG 32 - Randomized phase II trial on primary In 2014, 30 adult patients with advanced solid Ozogamicin (CMC-544) in combination with chemotherapy with high-dose methotrexate tumours were accrued into 9 Phase I studies, of Damia G, Sessa C. Success and Limitations of Temsirolimus (CCI-779) in patients with and high-dose cytarabine with or without which 2 were first in humans. Targeted Cancer Therapy in Ovarian Cancer. Prog relapsed or refractory CD22-positive B-cell thiotepa, and with or without rituximab, For 3 compounds tested (2 cytotoxics and 1 Tumour Res. 2014;41:89-97. Non Hodgkin’s Lymphomas. followed by brain irradiation vs. high-dose acting as PI3K/mTOR inhibitor), a full clinical Lead investigator: A. Stathis. chemotherapy supported by autologous stem development has been already planned in which Del Conte G, Sessa C, von Moos R, Viganò L, cell transplantation for immunocompetent IOSI will play an active role. Digena T, Locatelli A, Gallerani E, Fasolo A, Tessari Phase I study for patients with lymphoma. patients with newly diagnosed primary CNS About half of the patients treated were referred A, Cathomas R, Gianni L. Phase I study of olaparib Besides the IOSI, the study is open in other two lymphoma. from other Swiss centres or from Italian centres, in combination with liposomal doxorubicin in Swiss Centres (St. Gallen and Bern). Lead investigators: A. Ferreri, G. Illerhaus, E. Zucca. because of the possibility of IOSI to participate in patients with advanced solid tumours. Br J Cancer. international studies with innovative molecules 2014;111(4):651-659. • A Phase I, Multicenter, Open-label study of On 31.12.2014: 227 patients enrolled in 54 open in a limited number of centres outside IMGN529 administered intravenously in adult Institutes and 5 Countries (sample size: 200 Switzerland. Lennerz V, Gross S, Gallerani E, Sessa C, Mach patients with relapsed or refractory NHL. evaluable patients - Enrollment completed in The close collaboration with the CTU-EOC N, Boehm S, Hess D, von Boehmer L, Knuth Lead investigator: A. Stathis. Q3 2014). allowed us to offer a series of services for the A, Ochsenbein AF, Gnad-Vogt U, Zieschang J, The enrollment was concluded and the first management and conduct of clinical studies (such Forssmann U, Woelfel T, Kaempgen E. Immunologic • A phase I, dose-finding study of the bromodomain results should be presented in an abstract as the preparation of study documents and their response to the sruvivin-derived multi-epitope (Brd) inhibitor OTX015 in haematological during the 2015 edition of ICML. submission to the Regulatory Authorities) that vaccine EMD640744 in pazients with advanced malignancies. were instrumental in the selection of the IOSI as a solid tumours. Cancer Immunol Immunother. Lead investigator: A. Stathis. • IELSG 34 - A Multicenter Phase II study to participating centre. 2014;63(4):381-94. evaluate the clinical activity and the safety In 2 studies, a strict criterion for selection of Preliminary results of the phase I studies with profile of everolimus (RAD001) in marginal the patients was the presence of a molecular 1.7.2 Lymphoma Unit – IELSG IMGN529 and OTX015 were presented by zone B-cell lymphomas (MZL). dysfunction in the tumour tissues which could Emanuele Zucca MD PD Dr. Stathis as a poster at the 56th ASH annual Lead investigators: E. Zucca, A. Conconi. be targeted by the study drug which has a very Deputy Head Doctor at the IOSI meeting and as an oral presentation at the AACR- selective site of action. Because of the low NCI-EORTC International Conference on Molecular The study has been published in the British incidence of some of the molecular alterations The primary activities of the Lymphoma Unit in Targets and Cancer Therapeutics respectively. Journal of Haematology. looked for (10% to 40% of cases according to 2014 were dedicated to the development of the tumour type) it was necessary to evaluate clinical studies and the increasing and continuing 2. IELSG - Prospective Studies: • IELSG 37 - A randomized, open-label, the molecular profile of almost a ten-time higher collaborations with the activities of genomic multicenter, two-arm phase III comparative number of patients to identify those who could research conducted in the laboratory of Dr. • IELSG 30 - A phase II study of R-CHOP study assessing the role of involved mediastinal potentially benefit from the participation in the Francesco Bertoni. During the year 2014, the with intensive CNS prophylaxis and scrotal radiotherapy after Rituximab containing Phase I study. new international guidelines on the use of PET irradiation in patients with primary testicular chemotherapy regimens to patients with newly for the staging of non-Hodgkin lymphomas and diffuse large B-cell lymphoma. diagnosed Primary Mediastinal Large B-Cell Main funding the evaluation of responses to treatment were Lead investigators: U. Vitolo, E. Zucca. Lymphoma (PMLBCL). SAKK, Pharmaceutical Companies for specific published in the Journal of Clinical Oncology. On 31.12.2014: 34 patients enrolled in 13 Lead investigators: M. Martelli, AJ Davies, M. clinical studies. Dr. Zucca was an active member in the working Institutes and in 2 Countries (sample size: 50 - Gospodarowicz, E. Zucca. groups and is a co-author of two publications on End of trial expected for Q4 2015). On 31.12.2014: 138 patients enrolled in 38 Peer reviewed publications in 2014 what was called the "Lugano Classification". In The participant sample size has been expanded Institutes and 7 Countries (Sample size: 540 Bahleda R, Sessa C, Del Conte G, Gianni L, Capri 2014, the International Extranodal Lymphoma to better evaluate the data of disease-free patients - End of trial expected for Q4 2016). G, Varga A, Oprea C, Daglish B, Hospitel M, Soria Study Group (IELSG) successfully published the survival in the long term. This study provides JC. Phase I clinical and pharmacokinetic study of results of some studies. a unique opportunity to obtain meaningful • IELSG 38 - A phase II study of Chlorambucil ombrabulin (AVE8062) combined with cisplatin/ information on the role of central nervous in combination with subcutaneous Rituximab docetaxel or carboplatin/paclitaxel in patients Main areas of research system prophylaxis in a high-risk population. followed by maintenance therapy with with advanced solid tumours. Invest New Drugs. 1. Phase I studies: subcutaneous Rituximab in patients with

24 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 25 extranodal marginal zone B-cell lymphoma of in the prestigious Journal of Clinical Oncology, Médula Ósea; German High-Grade Lymphoma Director of the Breast Unit mucosa-associated lymphoid tissue (MALT accompanied by a very positive editorial. Study Group; German Hodgkin's Study Group; Lymphoma). Japanese Lymphorra Study Group; Lymphoma The Clinical Research Unit for Breast Cancer is Lead investigators: A. Stathis, S. Luminari, L. In parallel with the management of the clinical trial, Study Association; NCIC Clinical Trials Group; involved in clinical studies in patients with both Baldini, C. Thieblemkont, R. Gressin, E. Zucca. the update activity of the IOSI Lymphoma Database Nordic Lymphoma Study Group; Southwest early and advanced disease. The most significant continued on a regular basis. Oncology Group; United Kingdom National Cancer collaboration takes place within cooperative On 31.12.2014: 28 patients enrolled in 18 Research Institute. Recommendations for Initial groups on either national (SAKK) or international Institutes in 3 Countries (Sample size: 112 Main funding Evaluation, Staging, and Response Assessment of levels (International Breast Cancer Study Group patients - end of trial expected for Q4 2019). “IELSG 37 - A randomized, open-label, multicenter, Hodgkin and Non-Hodgkin Lymphoma: The Lugano – IBCSG, Breast International Group – BIG). two-arm phase III comparative study assessing Classification. J Clin Oncol. 2014;32(27):3059- Dr. Olivia Pagani also coordinates the research 3. IELSG Retrospective Studies: the role of involved mediastinal radiotherapy after 68. activities of the Senology Centre of the Italian Rituximab containing chemotherapy regimens to Speaking Switzerland (CSSI). During 2014, Dr. • IELSG 17 - Multi-institutional retrospective patients with newly diagnosed Primary Mediastinal Govi S, Christie D, Messina C, Bruno Ventre M, Pagani finalized the research project on pregnancy analysis of intravascular lymphomatosis. Large B-Cell Lymphoma (PMLBCL)”: Gracia Medina EA, Porter D, Radford J, Heo after breast cancer, within the framework of Lead investigators: A. Ferreri, M. Ponzoni. DS, Park Y, Martinelli G, Taylor E, Lucraft H, an intercontinental collaboration between BIG • Oncosuisse (KFS-2859-08-2011 from 2012 Ballova V, Zucca E, Gospodarowicz M, Ferreri and the North American Breast Cancer Study On 31.12.2014: 68 patients enrolled in 16 to 2014 - 3 years) - CHF 320'000.00 AJ; on behalf of the International Extranodal Group (NABCG). The POSITIVE protocol, which is Institutes and in 7 Countries. • Swiss National Science Foundation (SNSF from Lymphoma Study Group (I.E.L.S.G.). The clinical chaired by Dr. Pagani, began accruing patients 2013 to 2016 - 3 years) CHF 440'920. features, management and prognostic effects of in September 2014 and the first patient entered • IELSG 31 - A retrospective international study pathological fractures in a multicenter series of into the study was listed by the IOSI. During 2014, of primary extranodal follicular lymphoma. Oncosuisse: 373 patients with diffuse large B-cell lymphoma of two important studies on endocrine adjuvant E. Zucca, B. Pro, M. Federico, A. Gullermo a. Performance Agreement (from Q1.2013 until the bone. Ann Oncol. 2014;25(1):176-181. therapy in young women, in which Dr. Pagani Lopez. Q2 2014 - 1.5 years) - CHF 300'000.00. actively participated, were published in prestigious b. Performance Agreement (from Q3 2014 until Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri journals, including one in the New England Journal On 31.12.2014: 274 patients enrolled in 10 Q4 2016 - 2.5 years) - CHF 600'000.00. AJ, Vitolo U, Stelitano C, Brusamolino E, Cabras of Medicine (see list of publications) of which Dr. Instiutes and in 7 Countries. MG, Rigacci L, Balzarotti M, Salvi F, Montoto S, Pagani was the first author. Peer reviewed publications in 2014 (selection) Lopez-Guillermo A, Finolezzi E, Pileri SA, Davies • IELSG 35 - A retrospective international study Barrington SF, Mikhaeel NG, Kostakoglu L, A, Cavalli F, Giovanella L, Johnson PW. [18F] Main areas of research of primary extranodal lymphoma of female Meignan M, Hutchings M, Müeller SP, Schwartz Fluorodeoxyglucose Positron Emission Tomography 1. Two clinical studies in women with an early genital tract. LH, Zucca E, Fisher RI, Trotman J, Hoekstra Predicts Survival After Chemoimmunotherapy stage cancer: Lead investigators: G. Martinell, G. Ryan. OS, Hicks RJ, O'Doherty MJ, Hustinx R, Biggi A, for Primary Mediastinal Large B-Cell Lymphoma: Cheson BD. Role of Imaging in the Staging and Results of the International Extranodal Lymphoma • a study coordinated by SAKK (Swiss Group for On 31.12.2014: 47 patients, in 4 Institutes Response Assessment of Lymphoma: Consensus Study Group IELSG-26 Study. J Clin Oncol. Clinical Cancer Research), SAKK 26/10. and in 4 Countries. of the International Conference on Malignant 2014;32(17):1769-75. Lymphomas Imaging Working Group. J Clin Oncol. The primary objective of the study is to test Furthermore, the study IELSG 14, which was 2014; 32(27):3048-58. Mian M, Kwee I, Rinaldi A, Ponzoni M, Bhagat G, whether Oncotype DX® Recurrence score® conducted on a series of 499 primary bone Rossi D, Arcaini L, Gascoyne RD, Mollejo M, Baldini (RS) leads to a relevant proportion of changes lymphomas, generated four publications (Leukemia Cheson BD, Fisher RI, Barrington SF, Cavalli L, Thieblemont C, Gaidano G, Zucca E, Bertoni in adjuvant treatment recommendation in & Lymphoma, British Journal of Haematology, F, Schwartz LH, Zucca E, Lister TA; Alliance, F. Genome-wide DNA profiling identifies clonal patients with ER-positive early Breast Cancer. Oncologist and Annals of Oncology) on multiple Australasian Leukaemia and Lymphoma Group; heterogeneity in marginal zone lymphomas. Br J clinical problems in this type of lymphoma. The Eastern Cooperative Oncology Group; European Haematol. 2014;164(6):896-9. • a study coordinated by IBCSG (International main results of the study IELSG 26, on the Mantle Cell Lymphoma Consortium; Italian Breast Cancer Study Group), IBCSG 48-14/ prognostic role of PET in primary mediastinal Lymphoma Foundation; European Organisation 1.7.3 Breast Unit BIG 8-13, POSITIVE. lymphoma and on the optimal evaluation of for Research; Treatment of Cancer/Dutch Olivia Pagani MD response to chemotherapy by PET were published Hemato-Oncology Group; Grupo Español de Deputy Head Doctor at the IOSI and Clinical The primary objective is to assess the risk

26 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 27 of breast cancer relapse associated with clinically significant pathological fracture, This study aims at exploring if and how patients’ Gelber RD, Goldhirsch A, Francis PA; TEXT and temporary interruption of endocrine therapy radiation therapy to bone, surgery to bone preferences for IV or oral administration of SOFT Investigators; International Breast Cancer (ET) to permit pregnancy. The secondary or spinal cord compression). chemotherapy varies according to socio- Study Group. Adjuvant Exemestane with Ovarian objective is to evaluate factors associated demographic, clinical, health-related quality of Suppression in Premenopausal Breast Cancer. N with pregnancy success after interruption of c. SAKK 21/12. life and dispositional optimism. The expected Engl J Med. 2014;371(2):107-118. endocrine therapy. The main objective of the Phase I is to research outcome is to identify a patient- determine safety, tolerability and the centred typology that can complement clinical Partridge AH, Pagani O, Abulkhair O, Aebi S, 2. Five clinical studies in women with an recommended dose (RD) of CR1447 for guidelines in order to support prescription Amant F, Azim HA Jr, Costa A, Delaloge S, advanced stage of cancer: Phase II. The main objective of the Phase decision-making and communication. Freilich G, Gentilini OD, Harbeck N, Kelly CM, Loibl II is to assess activity and to determine the S, Meirow D, Peccatori F, Kaufmann B, Cardoso • a randomized clinical study coordinated by efficacy and tolerability of CR1447. 5. A clinical study of male breast cancer: F. First international consensus guidelines for IBCSG, IBCSG 42-12 (SNAP). breast cancer in young women (BCY1). Breast. • one clinical study sponsored by Novartis. • EORTC 10085. 2014;23(3):209-220. Longer first line chemotherapy duration has recently been associated with a modest, but The purpose of this trial is to inform the future A prospective observational study coordinated Senkus E, Cardoso F, Pagani O. Time for more significant improvement in overall survival clinical development of the two investigational by the EORTC. optimism in metastatic breast cancer? Cancer and a clinically meaningful and statistically agents in ER+ breast cancer, LEE011 (CDK4/6 Treat Rev. 2014;40(2):220-228. significant improvement in progression-free inhibitor) and BYL719 (PI3K-alpha inhibitor), Main funding survival, in metastatic breast cancer patients. both as doublet regimens in combination with SAKK, IBCSG, Novartis and other competitive and 1.7.4 Gastrointestinal Cancer Group The SNAP trial evaluates three schedules of letrozole as well as the triple combination of non-competitive external funding. Piercarlo Saletti MD nab-Paclitaxel as prolonged chemotherapy LEE011 and BYL719 with letrozole. Deputy Head Doctor of Medical Oncology Service administration strategy. Peer reviewed publications in 2014 (selection) 3. An observational study in young patients Cardoso F, Costa A, Norton L, Senkus E, Aapro M, Main areas of research • three clinical studies coordinated by SAKK: coordinated by IBCSG: André F, Barrios CH, Bergh J, Biganzoli L, Blackwell In 2014, our research activity continued in KL, Cardoso MJ, Cufer T, El Saghir N, Fallowfield collaboration with the laboratory for molecular a. SAKK 22/10. • IBCSG 43-09: Helping Ourselves, Helping L, Fenech D, Francis P, Gelmon K, Giordano SH, biology of the Cantonal Institute of Pathology, The primary objective of this trial is Others. Gligorov J, Goldhirsch A, Harbeck N, Houssami whereby we are finalizing the molecular to evaluate the efficacy in terms of The trial objectives are to identify a cohort of N, Hudis C, Kaufman B, Krop I, Kyriakides S, Lin characterization of squamous cell cancers of overall survival (OS) at 24 months of a young women (age 18-40) newly diagnosed UN, Mayer M, Merjaver SD, Nordström EB, the anal region. Moreover, we are continuing chemotherapy-free dual HER2-inbibition with breast cancer (early or advanced) to Pagani O, Partridge A, Penault-Llorca F, Piccart to search for molecular targets, which might with trastuzumab and pertuzumab (first- assess a broad range of variables at baseline MJ, Rugo H, Sledge G, Thomssen C, Van't Veer predict the outcome in the adjuvant treatment in line) followed by T-DM1 (second-line) and and over the course of the ensuing 10 years. L, Vorobiof D, Vrieling C, West N, Xu B, Winer E. patients with colorectal cancer, stage III. We are of a chemotherapy-containing dual HER2- The population of young women at diagnosis ESO-ESMO 2nd international consensus guidelines also continuing to cooperate within the GI group inhibition with trastuzumab and pertuzumab and in follow-up will be characterized regarding for advanced breast cancer (ABC2). Ann Oncol. of SAKK, which is particularly true for protocols (first-line) followed by T-DM1 (second-line) disease and psychosocial outcomes (e.g., 2014;25(10):1871-1888. dealing with advanced colorectal cancer, including in patients with HER2-positive metastatic presentation and disease characteristics Di Lascio S, Pagani O. Oligometastatic Breast phase II trials with rilotumumab with chemotherapy breast cancer. including evaluating women with metastatic Cancer: A Shift from Palliative to Potentially Curative for gastro-esophageal cancer and regorafenib as disease, fertility and menopausal issues). Treatment? Breast Care (Basel). 2014;9(1):7-14. a second line treatment in patients with hepato- b. SAKK 96-12. Pagani O, Regan MM, Walley BA, Fleming GF, cellular carcinoma progressing after sorafenib. The main objective of the trial is to establish 4. A qualitative study in collaboration with Colleoni M, Láng I, Gomez HL, Tondini C, Burstein that denosumab 120 mg given every 12 the Institute for Public Communication HJ, Perez EA, Ciruelos E, Stearns V, Bonnefoi HR, Main funding weeks is non-inferior to denosumab 120 mg dell'Università della Svizzera Italiana (USI): Martino S, Geyer CE Jr, Pinotti G, Puglisi F, Crivellari ABREOC; San Salvatore Foundation and Private given every 4 weeks. The primary endpoint D, Ruhstaller T, Winer EP, Rabaglio-Poretti M, Foundation. of this randomized trial is the time to first • myTAMINO: Examining Determinants of Maibach R, Ruepp B, Giobbie-Hurder A, Price KN, on-trial symptomatic skeletal event (SSE; Therapy Preference of Oncology Patients. Bernhard J, Luo W, Ribi K, Viale G, Coates AS,

28 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 29 Peer reviewed publications in 2014 cancer research) and will be carried out with the 1.8 IOSI Nursing Service carried out in outpatient IOSI departments. The Martin V, Zanellato E, Franzetti-Pellanda A, Molinari support of the Clinical Trial Unit (CTU-EOC). Monica Bianchi study has a mixed, quantitative and qualitative, F, Movilia A, Paganotti A, Deantonio L, De Dosso Nurse Director at IOSI design. S, Assi A, Crippa S, Boldorini R, Mazzucchelli L, During the analysis of the database (N=1302, (Regional Hospital of Bellinzona and Valli, Bellinzona It started in June 2013 and has been going on Saletti P, Frattini M. EGFR, KRAS, BRAF, and update 10.2014), we performed a preliminary (San Giovanni)) for about one year. Data are being collected PIK3CA characterization in squamous cell anal investigation on the oncological outcome of patients from patients (147 questionnaires and 16 cancer. Histol Histopathol. 2014;29(4):513-21. undergoing robot-assisted radical prostatectomy In recent years, nurses at the IOSI, as well as semi-structured interviews) and nurses (4 (RALP) (N=124, update 08.2014) three years throughout the EOC, are developing additional focus groups) in the outpatient departments. 1.7.5 Prostate Cancer Unit after the introduction of the surgical system "da knowledge and skills to be able to offer their At the end of 2014, all quantitative data were Enrico Roggero MD Vinci®" at the Regional Hospital of Bellinzona patients high-quality professional services. Their analyzed. Qualitative data analysis is still in Adjunct Physician of Medical Oncology Service and Valli, Bellinzona (San Giovanni). This analysis approach refers to the "Relationship-based care" progress. showed a favourable oncological outcome in the model which is grounded on the quality of the Main areas of research short term for patients surgically treated by RALP relationship between nurses and patients. This • Fatigue in cancer patients at IOSI. Starting from the experience gained with the and consistent with the current literature, with an model requires responsibility, accountability and Lead investigator: C. Pedrazzani. Uroboard and the database of prostate cancer, we overall rate of positive surgical margins of 32% investment in training and research as essential Collaborators: M. Bianchi, S. Tosi, C. Pedrazzoli- laid the foundations for the creation of a urological and a rate of 3-years biochemical progression- conditions to respond to the multiple patients Hutz, D. Valcarenghi. platform for coordination of studies and research free and specific survival of 74% and 100%, health needs more effectively and to contribute to projects. The platform aims at becoming a support respectively. A prospective observational study their well-being. The purpose of the study is to estimate the for clinical trials, providing a fast and efficient will be started in the coming months with the aim Within an ever-changing healthcare system, the prevalence and intensity of the symptom patient recruitment, especially for phase clinical to assess also surgical and functional outcomes, development of expertise in care is an essential fatigue in cancer patients hospitalized at IOSI trials, and a benchmark for independent research beyond the oncological one, for prostate cancer element to ensure competent and individualized and how it is managed by nurses. The study has projects (clinical, translational, biological). patients treated by robotic radical prostatectomy. care and to promote a real multidisciplinary a mixed, quantitative and qualitative, design. collaboration. To facilitate these processes, Fatigue in the patients admitted at IOSI, in the In October, the Ethics Committee (EC) authorized Furthermore, last year we also focused our research in the field of nursing is developing. period taken as a reference, will be assessed the protocol "Comparative study to assess the research, in addition to the study of classical The main purpose of the research in this area is by administering the Brief Fatigue Inventory impact of a multidisciplinary evaluation on the prognostic factors (such as Ki67, androgen to contribute to the development of knowledge (BFI - Italian version) and making some in-depth treatment of patients with prostate cancer (The receptors, PSA and nuclear factors), on the analysis in all areas in which nurses must take their own interviews. Nursing will be assessed through MAP CAT Study)". of the role of the neuroendocrine differentiation in decisions in the interest of patient and family. focus groups and analysis of the documentation This is the first IOSI clinical study in the urogenital prostate cancer in collaboration with the group of Nursing research has specific purpose and of care. The study was approved and funded by area and aims at assessing the impact of the Prof. G. Stanta by the University of Trieste. Also, as a contents, but not different methods compared to ABREOC and is awaiting the approval of the multidisciplinary discussion on the choice of part of this research field, the pilot epidemiological other fields of research. Ethics Committee. the treatment of patients with prostate cancer. study aiming at establishing the prevalence of On this basis, a Nursing Research and The study will compare treatment strategies for human papilloma virus in prostate cancer in the Development Office was set up within the IOSI • Information search of the patient with cancer prostate cancer in two groups of patients referred population of Ticino (research project funded by Nursing Service, headed by Monica Bianchi MSc, along its path of disease - INFO-SEEK. (Project to EOC hospitals: one historical control group whose ABREOC 2014 and carried out in collaboration under the responsibility of Dario Valcarenghi MSc. in partnership with USI). therapeutic decisions were taken by individual with Prof. L. Mazzucchelli by Cantonal Institute of Lead investigator: E. Germeni (USI). medical specialists (diagnosis in the period 2005- Pathology and with the support of the CTU-EOC) Main areas of research Collaborators: M. Bianchi, D. Valcarenghi, P. 2011 and without multidisciplinary discussion has just been submitted to the EC. • Patient education for oral antitumour Schultz (USI). by the Uroboard) and one experimental group, Clinical urological studies within national and treatments. enrolled in the study, whose therapeutic strategy international research groups (SAKK and EORTC) Lead investigator: D. Valcarenghi. The study aims at understanding and learning will be formulated jointly by multidisciplinary are always in progress. Collaborators: C. Pedrazzani, M. Zanon, M. the various methods used by cancer patients discussion (diagnosis in the period 2014-2017 Bianchi. to search for information in the various stages and multidisciplinary discussion by the Uroboard). Main funding of their disease. It is a longitudinal qualitative The study was funded by the “Fondazione Ticinese ABREOC; Fondazione Ticinese per la ricerca sul The purpose of the study is to explore how study that consists in in-depth interviews with per la ricerca sul cancro” (Ticino Foundation for cancro (Ticino Foundation for cancer research). education for oral antitumoural treatments is cancer patients followed at the IOSI. Each

30 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 31 consenting patient will be interviewed in three further to cancer and cancer treatments. nursing decisions taken on the basis of the data cancer patients and its correlation with nursing different moments of its path of disease: after Patients are asked to fill in the Body Image Scale collected by using the comprehensive geriatric decision-making”: project self-funded. diagnosis, after the start of the scheduled (BIS), an international validated tool, about 8 assessment, the logical path is reconstructed It started in 2013 and is still ongoing. treatment and after about six months from weeks before and after attending the workshop. (correlating each decision with the information the first treatment. The study will be conducted At the end of 2014, 18 workshops were set up gathered and the results obtained) and the area Peer reviewed publications in 2014 following the theories and methods of qualitative with 124 participants and up to now 59 women of professional autonomy actually practiced by Pedrazzani C, Bianchi M, Valcarenghi D, Dimonte research (Grounded Theory approach). The have agreed to participate in the study, which is nurses defined. At the end of 2014, nursing V. The implementation of recommendations in first interviews were conducted in December ongoing. decisions taken for ten patients were mapped. daily practice: the experience of the nurses of the 2014, after obtaining the approval of the Ethics The study is still ongoing. Oncology Institute of Southern Switzerland. Assist Committee. • Multicenter observational study to assess and Inferm Ric. 2014;33(4):189-197. describe risk factors for job burnout among Main funding • The use of the Peripherally Inserted Central nurses. “Patient education for oral antitumour treatments”: Awards 2014 Catheters (PICC) in the Oncology Institute of Lead investigator: R. Caruso (IEO – Milan, Italy). ABREOC in 2012. Pedrazzoli C, Columpsi-Ricci P. Best nurse Southern Switzerland: evaluation of the effects. Local investigator: D. Valcarenghi. Started in June 2013 and data collection stopped presentation at 18th Annual SASRO Meeting 2014: Lead investigator: M. Bianchi. Collaborators: C. Pedrazzani, L. Moser, M. on June 2014. "How do patients perceive their radiotherapy Collaborators: S. Lussu, S. Tosi, C. Pedrazzoli, Bianchi. Data analysis is still ongoing. treatment pathway: what can we learn from M. Zanon, P. Servida, L. Moser, D. Valcarenghi. personal experiences?". Lugano, Switzerland, 27th- The purpose of the study, in its local version, is “Fatigue in cancer patients at IOSI”: ABREOC in 29th March 2014. The study started in May 2011. Its purpose is to to estimate the prevalence of burnout among 2014. assess the effects of PICC use in patients, mainly IOSI nurses, using a special scale validated It is now awaiting approval by the Ethical Committee. in oncology. Data are collected systematically and translated into Italian (Burnout Potential It will last about a year. in a database and are periodically used for Inventory - Italian version - CRF). The data the process evaluation and adjustment. Every collection phase has already been completed. “Information search of the patient with cancer complication is in-depth analyzed to detect The percentage of respondents was 55.9%. The along its path of disease - INFO-SEEK”: project self- causes and data are compared with scientific phenomenon at the IOSI does not appear to be funded, in partnership with USI. litterature. At the end of November 2014, significant, except for a few individual situations. It started in December 2014 and will last about 345 PICCs were placed. The analysis carried However, there are situations significantly a year. out on the first 200 placed and removed different between the various departments on PICCs, showed a low rate of complications: some items, so as to require some corrective “The use of the Peripherally Inserted Central venous thrombosis (0.63/1000 cath day) or actions. The data were analyzed and discussed Catheters (PICC) in the Oncology Institute of suspected bacteremia (0.40/1000 cath day). with the nursing management in order to find Southern Switzerland: evaluation of the effects”: Each PICC remained on site for an average of the possible organizational solutions. project self-funded. 87 days (median: 72).The study is still ongoing. It started in May 2011 and is still ongoing. • Comprehensive geriatric assessment in older • Look Good - Feel Better workshops: an cancer patients and its correlation with nursing “Look Good – Feel Better workshops: an opportunity opportunity for cancer patients at IOSI? decision making. for cancer patients at IOSI?”: project self-funded. Lead investigator: M. Bianchi. Lead investigator: C. Pedrazzani. It started in January 2012 and is still ongoing. Collaborators: C. Pedrazzani, S. Tosi, C. Collaborators: M. Bianchi, S. Lussu, A. Cattaneo, Pedrazzoli, M. Zanon, D. Valcarenghi. D. Valcarenghi. "Multicenter observational study to assess and describe risk factors for job burnout among The study started in January 2012. Its purpose The purpose of this study is to evaluate the nurses”: not funded. At IOSI. is to assess the effects of Look Good - Feel correlation between the information gathered It started in summer 2013 and data analysis was Better workshops attendance on patients. In using multidimensional assessment tools and concluded in the spring of 2014. the workshops, patients learn, from expert nursing decision making process in the care of beauticians, how to enhance their body image elderly cancer patients. Starting from mapping “Comprehensive geriatric assessment in older

32 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 33 2 Neurocenter of Southern Switzerland (NSI) 2. Neurocenter of Southern Switzerland (NSI)

Prof. Alain Kaelin MD external funding for scientific research in 2014. of two senior neurologists, three assistants, and (NCT02219932). Head of Department The main focus of scientific activities at the three MS nurses run the ambulatory service Observational trials focus on new drug NSI currently relies on multiple sclerosis, sleep and concomitantly perform research activities. administration methods (TERIFL06965, Introduction disorders, movement disorders and stroke, even Research contributes to offering alternative and NCT02076841, NCT02247310). The “Neurocentre of Southern Switzerland” though, active research is also carried out in other innovative treatments to patients and to advancing comprises the services of neurology, neurosurgery, fields of clinical neuroscience. knowledge in the MS field. Investigator-initiated trials focus on the neuroradiology and neuroanesthesia as well as the For clinical research, one of the two seats of the The Multiple Sclerosis Centre focuses on three management of MS symptoms aiming at improving neuroscience research unit. The primary goal of Clinical Trial Unit of the Ente Ospedaliero Cantonale main research topics: the patients’ quality of life. the NSI is offering the highest quality of treatment (CTU-EOC) is located at the NSI. The Clinical Trial to the patient with the application and promotion Unit supports the investigators of the NSI for –– MS epidemiology is endorsed by the par- All the activities are carried out in close cooperation of an inter- and multidisciplinary approach. The investigator-initiated and sponsor-initiated studies ticipation at the Swiss Cohort of MS patients with the University Hospital of Basel (Study SMSC), performance of basic and clinical research, as and participated in several studies described (SMSC), an innovative project to establish a the Queens Square Hospital London concerning well as educational activities, are also a priority below. The respective projects in basic and clinical clinical database and a biological sample collec- treatment of lower urinary tract symptoms, and of the NSI with a close interaction between research carried out or still ongoing in 2014, are tion available for current and future research. for topics involving Neuroradiology, with Vita- research activities and clinical duties. Academic summarized in the following sections. The Centre has already included 75 of 100 Salute San Raffaele University, Italy and Brigham collaboration with national and international planned patients. & Women’s Hospital, Harvard Medical School, universities, as well as regular teaching activities Main areas of research of the NSI Boston. at the level of the Master of Medicine at the –– Upcoming MS treatments can be offered University of Bern and Basel, are contributing to 2.1 Multiple Sclerosis Centre to our patients with primary and/or Ongoing research: the success of the NSI. In 2014, several significant (Claudio Gobbi MD, Chiara Zecca MD) secondary relapsing remittent MS through changes occurred: Prof. A. Kaelin took over the our participation in several international a. Pain network and neuropsychological profile lead of the NSI and Neuroscience research, and The Multiple Sclerosis Centre aims at offering trials. Some of them evaluate convenient MS in multiple sclerosis and migraine patients - the basic research laboratory relocated to Taverne an optimal care for patients with multiple therapeutic compounds such as ocrelizumab a Clinical and Magnetic Resonance Imaging and its organization was redefined. Overall, the NSI sclerosis (MS) living mainly in the Ticino area. A (NCT01247324), fingolimod (NCT01779934), Study (EOC.NSIMS.14.01). obtained more than two million Swiss Francs of dedicated, multiple sclerosis specialized team siponimod (NCT01665144) or fampridine Lead investigator: C. Zecca

36 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 37 Collaborators: G. Riccitelli, E. Pravatà, A. disturbances in the Ticino MS population, the and cognitive assessments will be performed grant). Grant request (non-competitive grant) Cianfoni, C. Gobbi. prevalence of their various symptoms and using appropriate questionnaires. At present pending at Swiss MS Society (private foundation). their connection to demographic and clinical 32 out of 100 planned patients were enrolled This is a prospective, observational, cross- data. Data of female and male patients, and concluded the assessments. “Multidimensional assessment of fatigue in sectional, case-control, three-arm, single aged 18–80 years old, with urinary and/ multiple sclerosis – Observational study - Ticino centre research project aiming at investigating or sphincter disturbances are analyzed. d. A prospective, randomized double-blind, (EOC.NSI.13.02)”: Clara-Miller Stiftung (Società brain functional and structural substrates of Urinary and/or sphincter complaints as placebo-controlled, parallel-group, single Svizzera Sclerosi Multipla - Swiss MS Society) (non- pain network in patients with MS and migraine recorded during ambulatory visits by means of centrer, phase IV study of oral prednisone competitive grant). and at defining the relationship among brain structured questionnaires, videourodynamics, taper vs. placebo following intravenous functional activity, the severity of brain tissue PTNS treatment, demographic and MS steroids for the treatment of acute relapses in “A prospective, randomized double-blind, placebo- damage and specific neuropsychological profile medical history data yielding datasets of multiple sclerosis within the Ticino cohort (EOC. controlled, parallel-group, single centre, phase IV in MS patients with migraine. Assessments approximately 200 patients. Descriptive NC.10.04). study of oral prednisone taper vs. placebo following include Magnetic Resonance Imaging data statistics for demographics, prevalence of Lead investigator: C. Gobbi. intravenous steroids for the treatment of acute acquisition running 6 different sequences, urinary symptoms, sphincter dysfunction, Collaborators: C. Zecca, U. Candrian, L. relapses in multiple sclerosis within the Ticino EDSS score and neuropsychological tests Spearman rho correlation test for association Panicari, G. Disanto, V. Pifferini. cohort (EOC.NC.10.04)”: ABREOC. assessing executive functions, attention, of demographics, clinical urinary, and sphincter memory, and visuospatial abilities. The intrinsic symptoms will be used. This double-blind, randomized, placebo- 2.2 Sleep and Epilepsy group brain functional connectivity from MRI BOLD controlled, prospective trial aims at comparing (Mauro Manconi MD) data obtained at rest will be estimated. The c. Multidimensional assessment of fatigue in the efficacy, tolerability and safety of tapering microstructural and macrostructural brain multiple sclerosis – Observational study – doses of oral prednisone and placebo after The sleep and epilepsy laboratory’s scientific damage using high field T1 and DTI MRI Ticino (EOC.NSI.13.02). short-term high-dose i.v. methylprednisolone mission is to explore brain function during sleep techniques will be quantified. A correlation Lead investigator: C. Gobbi. on the recovery from an acute relapse in and sleep-related disorders in order to achieve between MRI findings and clinical and Collaborators: M. Manconi, C. Zecca, M. patients with clinically isolated syndrome, important pieces of knowledge in the new, intriguing neuropsychological measures in MS patients Caporro, L. Panicari, G. Riccitelli, S. Fulda, C. relapsing-remitting multiple sclerosis (RR-MS) and extremely growing field of sleep research. with and without migraine, and patients with Cartellina. and primary (PP-MS) or secondary progressive The group is mainly internationally recognized for only migraine will be established. Recruitment multiple sclerosis (SP-MS) with superimposed its results in the field of sleep related movement of 37 patients in each arm will be starting in The purpose of this cross-sectional, prospective, relapses. Inclusion criteria are female and disorders such as restless legs syndrome, periodic January 2015. observational, instrumental investigation is male patients with clinically isolated syndrome, limb movement disorders. For the past three 1) to provide a detailed characterization of RR-MS, PP-MS or SP-MS and experiencing an years, thanks to consolidated, local and external b. Prevalence and characterization of urinary and fatigue in a cohort of selected MS patients, acute relapse with clinical worsening (>1 point collaborations we have obtained 3 competitive sphincter symptoms in patients with multiple including a definition of the boundaries and the if EDSS ≤4.5 or 0.5 point if EDSS >4.5 or >2 large grants from the Swiss National Foundation; sclerosis - a retrospective analysis of clinical overlaps between fatigue, somnolence, mood points in one functional system of the Expanded two of them were focused on the impact of sleep practice data (EOC.NSIMS.14.02). disorders and attention dysfunction; 2) to see Disability Status Scale (EDSS), EDSS score 0–8, disorders in the stroke outcome, while the third Lead investigator: C. Zecca. how the prevalence and the overlaps between aged 18–80 years. They will be treated with one was on the effects of sleep related movement Collaborators: L. Panicari, C. Gobbi, U. Candrian, fatigue, somnolence, depression and attention methylprednisolone for 3 days and randomized disorders on cardiovascular system. A further A. Digesu. dysfunction are influenced by the method of to receiving either orally decreasing doses of competitive large grant was recently awarded assessment; 3) to better characterize the Prednisone for 25 days or placebo. 25 patients by the Italian Ministry of University to study the This is a retrospective analysis of clinical practice sleep structure in MS patients with fatigue have been enrolled so far, 24 of which have sleep related risk factors for perinatal depression, data. The patients have a MS experience with under both the macro- and microstructural concluded the trial. including a trial with light therapy to treat this various sphincter and urinary disturbances due point of view. Inclusion criteria are definite psychiatric complication of pregnancy. Other to the underlying neurological disease. The real diagnosis of MS (or clinical isolated syndromes Main funding sleep-related field of interest are represented by prevalence of these symptoms and their course according to the current criteria, Expanded “Pain network and neuropsychological profile in eating disorders during sleep and its relationship related to disease progression is little known. Disability Status Scale (EDSS) score < 7.0 and multiple sclerosis and migraine patients - a Clinical to obesity, the mechanism of disperception in The project aims at estimating the proportion last magnetic resonance imaging (MRI) within and Magnetic Resonance Imaging Study (EOC. primary insomnia, and sleep apnea. New starting of MS patients with urinary and sphincter previous 12 months. Fatigue, sleep, psychiatric NSIMS.14.01)”: ABREOC (hospital competitive areas of research, supported by small explorative

38 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 39 grants, are represented by sleep disorders in Computation analysis of periodic limb Movement Disorders (PLM/RLS) = 36 papers. dell’Università Italiana: Italian competitive attention deficit hyperactive disorder and by infra- movements during sleep and other infra-slow- • C. Bassetti (Bern University, Inselspital, CH): national grant: slow oscillating process in sleeping brain, In both oscillating process during sleep. Machine Sleep Stroke, Pregnancy related RLS = 9 M. Manconi (Lead investigator): “Restless cases, innovative tools like High-Density EEG will Learning Program in collaboration with IBM. papers. Legs Syndrome and Sleep Disorders During be used. The latter will also be addressed by using • Ferini-Strambi (IRCCS San Raffaele, IT): Sleep/ Pregnancy and Sleep Related Risk Factor for new sophisticated computerized learning machine d. Sleep disorders in Paediatrics, Hyperactive Epilepsy Disorders = 46 papers. Perinatal Depression”. Amount: Euro 901’000. programs in collaboration with IBM. Educational Attention Deficit Disorder. • O. Polo (University of Tampere, Finland): Spinal Duration: 2014-2017. initiatives as university master, European level’s Lead investigators: S. Miano, M. Manconi, V. lesioned model of PLM/RLS = 1 paper. courses in sleep medicine, exchanging scholar and Pezzoli, GP. Ramelli. • S. Happe (University of Münster, Germany): 4. EOC/IBM: fellowship programs and periodic meeting with Computer Analysis (LM during sleep) = 1 travel M. Manconi (Lead investigator); S. Fulda (Co- the general population, are a further fundamental Cycling alternating pattern as a diagnostic grant (ESRS – 2014). investigator): “Sleep Disorder Research. pillar of the group’s mission. marker of hyperactive attention deficit disorder. • I. Gorayeb (University of Bordeaux, France): Infra-Slow-Oscillation during Sleep”. Amount: Sleep microstructure and PLM in monkeys = $ 175,000. Duration: 1 year (started in These are the main projects performed or still e. Nocturnal Eating Disorder. 2 papers. December 2014). ongoing in 2014: Lead investigators: M. Manconi, P. Vinai. Main funding 5. Pharmaceutical companies: a. Sleep Related Movement Disorders: Restless Differential diagnosis, polysomnographic and 1. Swiss National Science Foundation (SNSF): Legs Syndrome (RLS) and Periodic Limb neuropsychological features of sleep-related • UCB-Pharma: Movements (PLM). eating disorder and nocturnal eating disorders • M. Manconi (Co-Applicant): “SAS CARE 1- Study M. Manconi (Lead investigator): “A Lead investigators: M. Manconi, S. Fulda. of leg movements in sleep, Sleep Disordered Pharmacogenetic Rodent Animal Model of Active Local Collaborations: Breathing (Sdb), Cardiovascular markers and Restless Legs Syndrome (RLS) And Periodic The impact of RLS/PLM on cardiovascular • A. Auricchio (Cardiocenter TI): RLS/PLM and blood pressure profile in transient ischemic Leg Movements (PLM)”. Amount: CHF function. RLS/PLM as a risk factor for cardiovascular Risk = 1 SNSF (Swiss National attacks (Tia)/Ischemic Stroke patients”. 150’000. Duration: 2012-2014 (Ended in perinatal depression. Respiratory related limb Science Foundation) grant. Amount: CHF 450’000. Duration: 2011-2014 February 2014). movements. Time structure of PLM in RLS and • P. Schulz (Science Communication University, (Ended in May 2014). other sleep disorders. RLS/PLM in multiple USI): Judisky Study (SNSF) Effective Clinical Trial SP0994: “A multicenter, sclerosis and their relationship with fatigue. Empowerment in Insomnia = 1 SNSF grant. • M. Manconi (Co-Applicant): “Sleep loss and double-blind, double-dummy follow-up study Treatment and management of long-term • C. Gobbi (Neurocenter): Sleep/Fatigue in MS = sleep disorders and their impact on the short- evaluating the long-term safety of lacosamide complication in RLS, in particular, the increase 1 paper (review), 1 ongoing study. and longterm outcome of Stroke”. Amount: (200 to 600mg/day) in comparison with phenomena. Time-structure and dopaminergic • S. Galati (Neurocenter): Sleep and PD = 1 CHF 597’000. Duration: 2014-2018. carbamazepine (400 to 1200mg/day), used response of periodic limb movements during ongoing study, (grant ABREOC). as monotherapy in patients with partial-onset sleep in the spinal lesion. • C. Cereda (Neurocenter): Sleep-related risk • M. Manconi (Lead investigator): “Autonomic or generalized tonic-clonic seizures (≥16 years) factors for CVD = 3 papers. function and cardiovascular risk in Restless of age coming from the SP0993 study”. Ended b. Sleep and Stroke. • M. Pons (Pulmonology, Civic Hospital): Central Legs Syndrome”. Amount: CHF 316’000 CHF. in November 2014. Lead investigators: M. Manconi, S. Miano, L. control of breathing during sleep = 2 papers Duration: 2013-2015. Ratti, C. Cereda, V. Stojanova. (for print). • Vifor Pharma: 2. International Short Visit grant (n. “A Randomised, Assessor- and Patient- blind, The impact of sleep disorders on Stroke Active External Collaborations: IZK0Z3_150808/1) for Dr. S. Silvani Multicenter, Placebo-controlled Study to outcome. Efficacy of early CPAP treatment in • S. Clemens (East Carolina University, Greenville, (University of Bologna): Assess the Efficacy and Safety of a Single stroke patients with sleep apnea in improving US): Basic Science (spinal dopaminergic Administration of ferric Carboxymaitose in the stroke outcome. network) = 2 papers. M. Manconi (Lead investigator): “animal model of Improving Outcomes in Iron Deficient Non- • J. Winkelmann (Harvard University, Boston, periodic limb movement during sleep”. Amount: anaemic Patients with restless Legs Syndrom”. c. Infraslow-Oscillations. US): Sleep Related Movement Disorders (PLM CHF 7'500. Duration: 1 month (March 2014). Duration: ongoing. Lead investigators: S. Fulda, M. Manconi, A. Hypoxia) = 2 papers. Bernasconi, C. Prosperetti. • R. Ferri (IRCCS Oasi Institute, IT): Sleep Related 3. MIUR Ricerca Finalizzata Ministero

40 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 41 2.3 Movement Disorders Centre S. Sarasso (University of Milan), P. Stanzione polysomnographic study is being conducted at Ticino (Foundation for the study of (Salvatore Galati MD, Claudio Staedler MD, (University of Rome). different stages of the disease. neurodegenerative diseases in adult and Paolo Paganetti PhD, Prof. Alain Kaelin MD) Funding: Pharmaceutical company; The recruitment of the subject is currently elderly people in Ticino). Fondazione malattie neurodegenerative finishing, and the data analysis is now starting. Research on movement disorders represents one dell’adulto e dell’anziano Ticino (Foundation for The relation between beta and gamma-band important research interest at the Neurocenter the study of neurodegenerative diseases in c. Electrophysiological effects of an acute block of oscillation and parkinsonian symptoms was of Southern Switzerland. In January 2014, Prof. adult and elderly people in Ticino). the nigrostriatal pathway with respect to the based on their identification in local field potential A. Kaelin joined the movement disorders research cortico-striatal and cortico-thalamic interplay. recordings from cortex and basal ganglia group. Currently, the priority of the translational Levodopa is the most effective treatment Lead investigator: S. Galati. of patients affected by PD. Indeed, a direct research efforts relies on the pathogenesis and for PD, but its therapeutic window becomes Collaborators: A. Kaelin, A. Stefani (University causative relation of beta band oscillations in potential treatment of dyskinesias, involuntary narrower in the course of the disease, mainly of Rome), A. Salvadè. PD was inferred by the subtle clinical worsening movements that develop in the course of the because of the development of levodopa- Funding: Fondazione malattie of akinesia given by stimulating the subthalamic long-term treatment of patients with Parkinson´s induced dyskinesia. Although evidence from neurodegenerative dell’adulto e dell’anziano nucleus with the beta band frequency. disease (PD) with levodopa. Both clinical research animal models of PD suggested a striatal Ticino (Foundation for the study of However, the dissociation of these oscillations and basic research are performare carried out. hyper-plasticity underlying the development neurodegenerative diseases in adult and and clinical symptoms is also apparent since it All basic research is performed in the “Laboratory of dyskinetic movements, their pathogenesis elderly people in Ticino); Parkinson’s disease is uncorrelated to the clinical state. In order to for Biomedical Neurosciences” (please see below). remains not entirely understood. In recent Swiss Foundation (or Parkinson Schweiz). explain these conflicting results between beta- Other collaborative projects are underway, mainly years, slow homeostatic tuning of intrinsic band oscillations and clinical motor symptoms in collaboration with the University of Bern. In excitability occurring during sleep has Spreading of slow cortical rhythms into the basal in PD, a closer monitoring of cortical and basal particular, a neurophysiological project financed been considered fundamental for network ganglia is a well-demonstrated phenomenon ganglia oscillation is conducting in the freely by the Swiss National Science Foundation and stabilization by sliding plasticity thresholds. in PD. Accordingly, striatal dopamine moving parkinsonian animal. investigating motor system recovery in children Hypothesizing an association between these depletion drives cortical-basal ganglia slow The data collection and analysis have been after stroke started in 2014 and the Centre sleep process and dyskinesia we measured wave coherences in urethane-anesthetized recently completed. A paper is now under participated in the development of new innovative the synaptic down-scaling during sleep and rats. The neuronal basis of this pathological evaluation. surgical treatment to treat movement disorders our results are consistent with an association synchronization has been the subject of several together with the group of PD Dr. C. Pollo at the between synaptic homeostasis and the investigations, and its behavioural relevance is e. Prevalence and genetics of movement Inselspital in Bern. development of dyskinesias. widely debated. The acute pharmacological disorders in Ticino - database and biobank. In addition, a database of almost 200 patients of This project was concluded, and the data inactivation of the SNc-striatal pathway led to Lead investigator: S. Galati. Ticino with movement disorders, in particularly published in “Neurobiology of Aging” journal. a fast developing coherence between cortex Collaborators: A. Kaelin, C. Städler, C. Wider PD, has been set up and will be useful for the and basal ganglia time-looked with a significant (University of Lausanne). Funding: Fondazione performance of epidemiological and clinical b. Role of sleep homeostasis in the development contralateral akinesia. This procedure offers malattie neurodegenerative dell’adulto e studies and an ambitious translational research of levodopa-induced dyskinesias in PD patients. the advantage of detecting electrophysiological dell’anziano Ticino (Foundation for the study project using skin biopsy to diagnose Parkinson’s Lead investigator: S. Galati. changes irrespectively of chronically developing of neurodegenerative diseases in adult and Disease has been funded by the Swiss Parkinson Collaborators: A. Kaelin, C. Städler, S. Sarasso compensatory mechanisms. elderly people in Ticino). Association and is now starting. (University of Milan). Funding: ABREOC (hospital competitive fund); d. Time course of the development of beta ad This database was created to capture the The main studies started or continued in 2014 Fondazione malattie neurodegenerative gamma-band oscillations in the basal ganglia spectrum of movement disorders in Ticino are the following: dell’adulto e dell’anziano Ticino (Foundation for of Parkinsonian rats with and without levodopa- population. We are currently collecting clinical the study of neurodegenerative diseases in induced dyskinesia. data as well as additional examinations. The a. Role of sleep homeostasis in the adult and elderly people in Ticino). Lead investigator: S. Galati. scope is ultimately to capture the mutation development of levodopa-induced dyskinesias: Collaborators: JC. Möller, A. Kaelin, A. Stefani, frequency of genes involved in these diseases electrophysiological and molecular analysis in Based on the findings in rodents mentioned (University of Rome), A. Salvadè, V. D’Angelo mainly the monogenic forms of PD. a Parkinsonian rat model. above, the analysis was extended to patients (Universtity of Rome). Lead investigator: S. Galati. affected by PD. In order to demonstrate the Funding: Fondazione malattie f. Modulation of striatal gene expression changes Collaborators: A. Kaelin, C. Staedler, A. Salvadè, hypothesis, a cross-sectional high-density neurodegenerative dell’adulto e dell’anziano in Parkinsonian rats with levodopa-induced

42 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 43 dyskinesia. mechanisms specifically involved in children. striatal opioidergic system in parkinsonian rats”. 4) Helios Clinic, Zihlschlacht, Switzerland. Lead investigator: A. Kaelin. The whole study is performed within the Amount: CHF 55’000 (international postdoc 5) Department of Neuroscience and Imaging University Collaborators: S. Sgroi. context of the Swiss Neuropaediatric Stroke visiting grant for 1 year). Duration: 1st January “G. d’Annunzio”, Chieti-Pescara, Italy. Funding: Fondazione Baasch Medicus and Registry (SNPSR). The SNPSR is a population- 2015 - ending December 2015. Rehabilitation after stroke improves motor Fondazione malattie neurodegenerative based registry prospectively collecting data on functions by promoting plastic changes. dell’adulto e dell’anziano Ticino (Foundation for childhood stroke and represents the unique 2.4 Stroke Centre However, after completing standard the study of neurodegenerative diseases in possibility to study children suffering from (Claudio Städler MD, Vesna Stojanova MD, CW. rehabilitation, 50–60% of patients still show adult and elderly people in Ticino). an arterial ischaemic stroke on a nationwide Cereda MD) some degree of motor impairment and basis. This multicenter project will strengthen require at least partial assistance in activities This is a Ph.D. thesis of the “Graduate School this Swiss initiative, and the data of this study The Stroke Unit EOC (SUN EOC) was accredited of day living. Therefore, the exploration of for Cellular and Biomedical Sciences” of the will allow to determine variables that influence as a Comprehensive Stroke Centre in late 2013 other approaches to promote recovery is University of Berne with S. Sgroi as a doctoral the cortical reorganisation and outcome after and, therefore, recognized as a one of the Swiss compulsory. After stroke, according to the student and Prof. A. Kaelin as the thesis childhood stroke. The NSI is collaborating centres of excellence for the cure of patients with model of interhemispheric rivalry, transcallosal supervisor. This project focuses on the role of on this project mainly thanks to its expertise stroke. The Stroke Centre offers an optimal care inhibition becomes symmetric and motor the endogenous opiodergic neuropeptides in in Transcranial Magnetic Stimulation of the for patients with cerebrovascular diseases. A deficits are also due to reduced output from levodopa-induced dyskinesia. Please see below motor system. dedicated and multidisciplinary stroke specialized the damaged hemisphere and excess of “Laboratory for Biomedical Neurosciences”. team take care of the patients in the acute phase inhibition of the damaged hemisphere from Main funding (inpatient unit) and also in a specialised outpatient the intact hemisphere. Thus, improvement g. Alpha synuclein oligomers detection by skin 1. Parkinson’s disease Swiss Foundation: clinic. The group also performs research activities, of motor function may be induced by either biopsy: a novel early biomarker for parkinson mainly focused on 4 topics in clinical research: up-regulating excitability of the affected disease? • S. Galati (Lead investigator): “Role of motor stroke epidemiology, acute stroke treatment, cortex or down-regulating excitability in Lead investigator: A. Kaelin. thalamus in parkinsonian state”. Amount: CHF stroke prevention, and improving stroke recovery the intact one. This may be achieved by Collaborators: G. Melli, P. Paganetti 342’923. Duration: October 2014 - ending in the acute phase. transcranial direct current stimulation (tDCS), Funding: Parkinson’s disease Swiss Foundation. December 2017. a form of non-invasive brain neuromodulation. These are the main projects performed or ongoing In this study the hypothesis of combining This is a translational research project • A. Kaelin (Lead investigator): “Alpha synuclein in 2014: bihemispheric tDCS (anodal, excitatory, of the investigating the potential role of skin biopsies oligomers detection by skin biopsy: a novel early ipsilesional motor cortex and cathodal, inhibitory, in the early diagnosis of Parkinson’s Disease biomarker for parkinson disease?”. Amount: a. Rehabilitation combined with bi-hemispheric of the contralesional motor cortex), with (please see below “Laboratory for Biomedical CHF 327'627. Duration: October 2014 - transcranial direct current stimulation in simultaneous physical/occupational therapy Neurosciences”). ending December 2017. subacute ischemic stroke: a randomized, in the subacute phase of ischemic stroke, may controlled, double-blind study - The Re.Com. improve upper limb motor recovery in humans. h. Cortical Reorganisation of Cerebral Networks 2. ABREOC: Bi.Ne. (Rehabilitation Combined with Methods: this study is a randomized, controlled, after Childhood Stroke: Impact on Outcome. Bihemispheric Neuromodulation) post-stroke double-blind, cross-over, multicenter, clinical Lead investigator: M. Steinlin, University of “Ruolo della sleep homeostasis nello sviluppo delle study. trial. Thirty-six ischemic stroke patients Berne. discinesie indotte dalla L-Dopa nei pazienti affetti Lead investigators: RRM. Müri3), CW. Cereda2). in the subacute phase will be recruited in Co-investigator at the NSI: A. Kaelin. da malattia di Parkinson in fase avanzata (Role of Collaborators: D. Dinacci1), G. Bianco1), V. three Swiss centres of neurorehabilitation. Funding: Swiss National Science Foundation sleep homeostasis in the development of levodopa- Staojanova1), F. Conti2, C. Möller1), L. Petrini1), J. After stratification based on the Fugl-Meyer (SNSF). induced dyskinesias in PD patients)”. Amount: CHF Frangi1), S. Neumann5), M. Ochsner5), L. Petrillo, Assessment Upper Extremity according to 96’000. Duration: 24 months. D. Zutter, CL. Bassetti, A. Uncini. the severity of the deficit, the patient will This is an important multicenter project using Funding: ABREOC (hospital competitive grant). be randomized to receive in addition to a fMRI and Transcranial Magnetic Stimulation 3. International Brain Research Organization: 1) Neurocenter of Southern Switzerland, Lugano, standardized physical/occupational treatment, for investigating motor recovery after stroke Switzerland. 2) Hildebrand Clinic, Brissago, Switzerland. anodal tDCS of the ipsilesional motor cortex and in children. The long-term goal is to develop A. Kaelin / Wei Song (Chengdu China) (Lead 3) Cognitive and Restorative Neurology, Departments cathodal tDCS of contralesional motor cortex therapeutic strategies better adapted to investigators): “Corticostriatal plasticity and of Neurology and Clinical Research, University Hospital, (1.5 mA, 30 minutes) (group 1: 12 patients) or children through a better understanding of the Parkinson’s Disease: Investigating the role of the Inselspital, Bern, Switzerland.

44 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 45 sham stimulation (group 2: 12 patients) at five Main funding (MCI). The primary objective is to determine aneurysmal subarachnoid haemorrhage days/week. After three weeks of treatment, ABREOC. at T0, which neuropsychological tests better (aSAH). The aim is the prospective group 1 and 2 will cross-over and will be treated allow discrimination between MCI subjects with implementation of a widely employed, for other three weeks. Group 3 (12 patients) 2.5 Neuropsychology AD markers (MCI CSF AD+) and MCI subjects standardized neuropsychological- and (Health- will receive physical/occupational treatment (Leonardo Sacco MD) without AD markers (MCI CSF AD-). The related Quality of Life) HrQoL outcome battery and sham tDCS for six weeks. The assessment secondary purpose of the study is to compare of high quality. Such efforts may help to identify will be performed before starting tDCS, at week The Neuropsychology and Behavioural Neurology at T1, after one-year follow-up, the proportion subtle but important treatment effects, which 3, at week 6, and 6 months after treatment. laboratory provides a comprehensive assessment of subjects that convert into AD (CDR≥1) and may otherwise go unnoticed. The Swiss SOS- Outcome measures are the Fugl-Meyer of adult patients with cognitive or behavioural subjects with stable cognitive status (CDR=0.5) NPsych study has been designed to improve Assessment Upper Extremity, the extended symptoms. Neuropsychological assessment in the two groups (MCI CSF AD+ and MCI CSF the detection of neuropsychological deficits, Barthel Index, the Ashworth scale, the Test of involves a systematic evaluation of higher cognitive AD-). depression, anxiety, and fatigue; following aSAH Upper Limb Apraxia, the grip strength evaluated abilities: intelligence, executive functions, attention, in Switzerland; assess the HrQoL in aSAH by the Jamar Hydraulic Hand dynamometer. memory, language and visuo-spatial functions. b. Neurocognitive assessment in the metabolic patients in Switzerland; develop and validate a Potential value of the project: this study is The case studies include suspected memory and aging cohort "The NAMACO study". neuropsychological testing battery, which may designed to provide a class I evidence of problems and dementia; cognitive and behavioural Investigators: M. Cavassini, S. Simioni, F. Schöni- be used for future studies on this subject. the possible adjunctive restorative effect of deficit resulting in various neurological and Affolter, S. Clarke, A. Calmy, M. Michel, D. Fasel, bihemispheric tDCS combined with physical/ neurosurgical conditions, such as stroke, epilepsy, U. Kunsel, A. Cusini, K. Gutbrot, C. Di Benedetto, 2.6 Neurosurgery occupational therapy in the subacute phase Parkinson's disease, multiple sclerosis, brain R. Pignatti, P. Vernazza, H. Kovari, P. Brugger, (Prof. Michael Reinert MD) after stroke. tumours, traumatic brain injury, learning and R. Du Pasquier. developmental disorders. A dedicated team of Funding: SHCS 2012 (external financial In 2014, the Department of Neurosurgery b. Other Academic driven studies: senior neurologists and three neuropsychologists support). focussed on establishing clinical research run the outpatient laboratory and concomitantly This study is included into the metabolic and together with the EOC Clinical Trial Unit (CTU-EOC). 1. Local Co-investigators (CW. Cereda, V. perform research activities. aging cohort whose importance has been A clinical database for patients suffering gliomas Stojanova, C. Staedler) in SWISS (Swiss The topic of the research is the early diagnosis acknowledged by the scientific board and was developed together with the Swiss Glioma thrombolysis registry), since 2008. of dementia and HIV-associated neurocognitive external reviewers. The overall purpose of this Network, the Department of Neurosurgery and Lead investigator: M. Arnold, Inselspital, Bern. disorders. The research activity involves local and investigation is to expand the current knowledge the University of Bern. On the same topic, the national participations. about HIV-associated neurocognitive disorders analysis of mRNA in patients with Glioblastoma is 2. Steering Committee (CWC) and Local Co- (HAND) in the HIV aging population. The current undertaken as part of the research collaboration investigators (CW. Cereda, V. Stojanova, C. The main studies in 2014 were: proposal aims at clarifying the global scope with the IOSI, the Institute of Pathology of Canton Staedler) in SSR (Swiss Stroke Registry). and practical issues of the study and asks only Ticino, the Department of Neurology and the Lead investigator: L. Bonati, University Hospital, a. A-beta 42, tau and phosphorylated-tau liquor for the financial support of the neurocognitive University of Zurich. Basel. alterations in patients with mild cognitive assessment of non-complaining patients, as The clinical introduction of the intraoperative CT- impairment (CDR: 0.5) reflect amyloid well as the financial support of the neurological, Airo is analyzed in a clinical protocol approved 3. I disturbi respiratori in sonno in corso di TIA/ accumulation and neuronal damage. Are MRI and CSF assessment of control patients. by the Ethics Committee (EC) together with the ictus ischemico: elementi clinici, prognostici, a semantic memory, ecological memory, CTU-EOC. In the field of vascular pathologies, fisiopatologici (Sleep breathing problems under and dual-task tests coherent with the c. Neuropsychologic outcome after aneurysmal patients are followed using a swiss wide registry TIA/ ischemic stroke: clinical, prognostic, neurodegeneration? subarachnoid haemorrhage – a new SOS. Clinical research in spinal pathologies was in pathophysiologic elements). Lead investigators: L. Sacco, S. Rossi, R. Pignatti. implementation of the prospective multicenter progress and resulting in invited lectures, posters Principal Investigator: M. Pons. Funding: ABREOC. Swiss SOS study. and scientific publications. Collaborators: CW. Cereda, V. Stojanova. Lead Investigators: M. Stienen, R. Weisshaupt, Basic research projects (NRP 64, CTI) were The purpose of the study is to determine which D. Valsecchi, M. Arrighi, M. Reinert, DE. Kuhlen, ongoing in 2014 and will terminate in 2015 where 4. Pharmaceutical trials: neuropsychological markers (semantic memory, S. Rossi, L. Sacco. final results will be published. SOCRATES. executive functions, memory-ecological test) Funding: Registre Suisse Hemorragie Local investigators: V. Stojanova, CW. Cereda. better reflect the neurodegenerative damage Sousarachn. These are the main projects performed or still in patients with mild cognitive impairment In the first step, we include all patients with ongoing in 2014:

46 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 47 a. New scalp electrode arrangements for The trial started in October 2014 and the cases with lumbar fractures type A1 (Aospine in Switzerland, to foster clinical research obtaining motor evoked potentials (MEPs) of sample size is 300 patients. classification) nonoperatively followed for a and collaboration between eight Swiss lower limbs during surgery. period of 12 months. The clinical and radiological neurovascular centres, to guide the future Investigators: L. Valci, M. Dalolio, L. Toffolet, J. c. Vertebroplasty and kyphoplasty with O-arm data were collected and prospectively analyzed. direction of aSAH management in Switzerland. Carugati, A. Pratesi, E. Colamartino, C. Gobbi, technology: a retrospective analysis of a single We took into account lumbar pain, presence The Department of Neurosurgery joined the M. Reinert. centre. or absence of neurological signs, and degree of study in 2013 and in 2014, it provided all the No funding, internal research. Lead investigators: D. Valsecchi, P. Scarone. kyphosis. We followed the patients with lumbar retrospective data about SAH treated in the radiograms at 2 weeks and 12 months, and CT hospital from 2009 to 2013. Actually on-line Transcranial electrical stimulation (TES) is Retrospective review that concerns all patients scan at 3 months. the website (www.swiss-sos.ch). an electrophysiological technique used in with osteoporotic fractures which were neurosurgery, orthopedics and vascular treated at our Department of Neurosurgery f. Intraoperative localization of thoracic h. Retrospective Assessment of Extent of surgery to elicit motor responses when from 01.01.12 to 31.12.2012. Among these meningiomas with contrast-enhanced cone- Resection (EOR) and Survival in CRET eligible continuous monitoring of motor functions is patients, we selected only those who underwent beam CT imaging. Glioblastoma Patients. required; however it is well known that motor «stand alone» kypho/vertebroplasty, even Lead investigators: D. Valsecchi, T. Rochat Local investigator: M. Dalolio, M. Reinert, GF. evoked potentials (MEPs) from the lower limbs on multiple levels, excluding those cases Negro, P. Scarone. Pesce. are difficult to obtain because of the anatomically where a fixation with screws and bars was No funding. unfavorable cortical representation of the leg: required. Complications, radiation exposure, Retrospective analysis of a series of 5 patients for this reason MEPs are obtainable with high- and outcome were analyzed. The primary affected by thoracic meningiomas treated with A multicentric retrospective study including intensity current only or even not at all. objective of the study is to identify the benefit surgical resection. All the patients underwent 8 Neurosurgery Departments in Switzerland This research is aimed to evoke motor of using spinal neuronavigation during cement surgery after a complete path of radiological direct by Inselspital of Bern. All patients, responses from the lower limbs more easily augmentation procedures on the spine. evaluation (MRI, CT scan). Intraoperatively, who underwent resection of a glioblastoma and with lower intensity: results could have we performed a contrast-enhanced 3D CT (confirmed by histological analysis) between relevant implications in surgery and refractory d. Utility of preoperative MR imaging in thoracic with O-arm, n order to detect the position 1st August 2008 and the 31st December pain treatment as well. and lumbar vertebral fractures treated in the of the tumour in depth. We then planned 2013, were identified. These patients are The trial started in December 2014. acute phase. the approach with the neuronavigation and screened according the inclusion/exclusion Lead investigators: P. Scarone, D. Cipriani. performed a surgical act “tumour-centred”. In criteria (CRET eligible patients): ≥18 age, b. SWITCH: Swiss trial of decompressive all cases, the tumour was perfectly identified KPS≥60, newly diagnosis of glioblastoma, craniectomy versus best medical treatment A retrospective study on 53 patients admitted and excised. Spinal neuronavigation allowed for surgical extent resection and not biopsy, of spontaneous supratentorial intracerebral during the year 2013, affected by vertebral a reduction in surgical time and more precise preoperative T1 -/+ MR images, early (<72 hemorrhage: a randomized controlled trial. fractures type A/B, which were surgically identification of the level of the lesion. hours) postoperative T1 -/+ MR images. A Lead investigator: P. Scarone. treated in the acute phase. Clinical and panel of blinded neuroradiologists from Bern will Collaborators: C. Cereda, V. Stojanova, D. radiological data were registered. Spine CT g. Swiss SOS. assess the extent of resection on the encoded Valsecchi, T. Robert. scan and MR were done preoperatively in all Lead Investigator D. Valsecchi. postoperative MRI of these CRET eligible Funding: Inselspital-Bern. cases. The primary objective of the study is Co-Investigators: M. Arrighi, D. Kuhlen, M. Reinert. patients. Local investigators will collect the to analyze the role of the MRI in the definition following clinical data (at least 1 year follow-up). The study is a prospective, multicenter of the surgical strategy and to compare data The Swiss SOS is a nationwide, multicenter The aim of the study is to identify a difference randomized trial that has the primary from CT with data from MRI in the diagnostic clinical study on patients with aneurysmal in surveillance between patients underwent a objective to determine whether a strategy process of these fractures. subarachnoid hemorrhage. It was initiated complete (100%) extent surgical resection of decompressive surgery and best medical in 2008, and evolved to be a prospective, of glioblastoma and patients underwent an treatment in patients with spontaneous ICH will e. Natural history of thoracolumbar type A1 institutional-review-board approved continuous incomplete extent surgical resection (<100%). improve outcome compared to best medical fractures: prospective analysis of a single database, currently containing anonymous treatment only. Secondary objectives are to centre series over 2 years. information on > 1500 patients. The aims i. Radiological fusion rate in 1 or 2 level lumbar analyze mortality, dependency and quality of Lead investigators: D. Botta, P. Scarone. of the Swiss SOS are: to serve as a tool for arthrodesis: comparison between PEEK and life of each treatment. An observational arm is disease monitoring in Switzerland, to measure long carbon fiber reinforced polymer (ostaPEK) included. Trial duration is 4 years. The prospective analysis of a series of 35 and control the quality of aSAH treatment interbody cages.

48 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 49 Lead investigators: M. Dalolio, P. Scarone. Regional Hospital of Lugano are a reference site brain focal contrast-enhancing lesions, image posterior fossa surgeries, epilepsy surgeries, No funding, internal research. for Siemens Medical, and are currently testing quality, artifacts and scan duration, between complex spinal surgery, and stereotactic new-developing WIP (work in progress) MRI three different high-resolution T1-weighted and interventional neurovascular techniques. A retrospective study including patients with sequences and images post-processing software. post-gadolinium sequences (SPACE, VIBE and Neuroanesthesia locations include multiple degenerative lumbar diseases (degenerative MPRAGE). Ethical committee authorization MRI-equipped operating rooms plus advanced disc diseases or degenerative spondylolisthesis) These are the main ongoing projects in 2014: request for this retrospective assessment is neurovascular interventional suites. During underwent lumbar fusion of 1 or 2 levels with being submitted. 2014 Dr. N. Bonello, junior anesthesiologist at PEEK cages (between 2007 and 2012) and a. Vertebral Body Stenting and Cement the department, successfully completed a one- with ostaPEK cages (between 2013 and Augmentation to Restore Structural Stability in Main funding year fellowship at one of the busiest specialist 2014). Patients who underwent a CT lumbar Extreme Spinal Osteolysis. A donation of 10,000 CHF on the neuroradiology neurosciences NHS trust in the United Kingdom, scan at least 6 months after surgery, are Investigators: A. Cianfoni, E. Raz, G. Cicciò, P. fund, held by the finances of Regional Hospital of “The Walton Centre” in Liverpool. screened. We collected clinical data including Scarone, V. Espeli, GF. Pesce, G. Bonaldi. Lugano, by MedCare Services GmbH. Oswestry disability index. We compared disc The research activity of our team mainly focused fusion on CT images with radiological criteria Vertebral augmentation can be used in 2.8 Neuroanaesthesia on 3 projects: used by Schimmel in his article “PEEK cages in neoplastic vertebral lesions for pain palliation (Paolo Maino MD) lumbar fusion: mid-term clinical outcome and and/or stabilization of collapsed or at-risk-of- a. Intrathecal therapy devices: Fluoroscopic- radiological fusion”. The incidence of surgical collapse vertebral bodies. Osteolysis widely The EOC Pain Management Centre promotes the guided intrathecal pump refill and prevention of revision is established and compared between involving cortical margins of the vertebral highest possible quality of life for patients with pocket fill. the two groups of patients. The aim of the study body pose a risk of cement leakage and can persistent pain, providing accurate diagnosis and Lead investigator: P. Maino. is to establish the better disc fusion e clinical ultimately limit the amount of bone cement direct interventions to reduce, eradicate or manage Funding: Self-sponsored. outcome of patients who underwent lumbar that can be injected, resulting in insufficient the pain. It provides support particularly around fusion of 1 or 2 levels with ostaPEK cages stabilization. We wish to retrospectively assess the management of pain problems of high medical This is a prospective observational method instead of PEEK cages. technical feasibility, clinical effectiveness and and psychological complexity, and around the use comparison study on adult patients carrying complications of the cement augmentation of of controlled drugs, minimal invasive interventions, intrathecal pumps for pain or spasticity control 2.7 Neuroradiology vertebral bodies affected by extreme osteolysis and neuromodulation. The ambulatory service that undergoing regular refills. We compared the (Alessandro Cianfoni MD) by the use of implantable vertebral body is present in all EOC hospitals has the mission of difference expressed in millimeters between the stents, to provide stability and bone cement providing specialist evidence-based consultations identification markings of fill port centre using Neuroradiology Service of the NSI provides containment. The procedures have been and the most up- to-date treatments to all chronic the blind technique and fluoroscopic imaging. a comprehensive array of state of the art performed at NSI in the last 16 months. Ethical pain patients in Ticino. morphological and functional advanced diagnostic committee authorization request for this In 2014, Dr. P. Maino performed the first implant of b. Neuromodulation RELIEF STUDY (A7007), neuroimaging, advanced innovative image- retrospective assessment is being submitted. dorsal root ganglion stimulation in Switzerland and A Global Registry to Evaluate Long-Term guided minimally invasive spine interventions, few months later, the first Spinal Cord Stimulation Effectiveness of Neurostimulation Therapy for and endovascular neuroradiology procedures. b. High-resolution post-contrast imaging at System with Burst Technology (St. Jude Medical, Pain. It is a heavily clinically-oriented service, with all 3 Tesla: a comparison of three different Inc.). This new modality of neurostimulation Lead investigator: P. Maino. its physician being employed 100% for clinical techniques. is designed to reduce pain, improve patient Funding: Boston Scientific International SA. work, except for one of its doctors, having a 20% Investigators: E. Pravatà, L. Danieli, D. Distefano, satisfaction and allow reduced paresthesia (a research appointment. A. Cianfoni. tingling sensation associated with stimulation). c. Intrathecal pump refill: reservoir fill port Nevertheless, there were scientific interest and The new device offers patients traditional tonic identification by palpation versus ultrasound, a ongoing academic cooperations during 2014, Obtaining post-gadolinium T1-weighted images spinal cord stimulation (SCS) in addition to Burst mono-centre prospective comparison study in with Inselspital of Bern, San Raffaele Hospital in with high spatial and contrast resolution is a Technology for improved stimulation options. patients undergoing regular intrathecal pump Milan, through the SM centre of NSI, with KSA critical requisite for the detection of brain The Neuroanesthesia service is responsible refill. in Aarau. The main research interests involve small neoplastic and inflammatory enhancing for the anesthetic care of patients undergoing Lead investigator: P. Maino, E. Koetsier. clinical applications of advanced neuroimaging, lesions and tumour grading, with MRI. We neurosurgical procedures, including craniotomies and spine image-guided oncological procedures. wish to perform a study to compare, in a 3T for brain tumours, aneurysms and arteriovenous Intrathecal drug therapy with implantable Furthermore, Neuroradiology and Radiology of MR system, the detectability and conspicuity of malformations, carotid endarterectomies, intrathecal pumps is being utilized increasingly

50 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 51 for the treatment of chronic refractory pain diabetic small fiber neuropathy in the feet. innovative, functional analysis and state of the disorders and as experimental models for testing and spasticity. However, performing the The secondary objectives are to assess art molecular and genetic methodologies. The new therapeutic interventions. regular refill procedures of the pumps with the neuropathic pain components, pain and studies focus on the elucidation of the molecular In 2014 the LBN received substantial financial commonly performed "blind" technique carries paresthesia distributions, central sensitization, mechanisms involved in the initiation, progression support by competitive research grants, by the potential risk of medication injection into efficacy of DRG-SCS on quality of life, physical and consequences of motor disorders such as charitable organizations and by benevolent donors the subcutaneous tissue, which can lead to an functioning, mood, global improvement, and the Parkinson’s disease or of other neurodegenerative for a total of more than 1.8 CHF million covering overdose. The primary purpose of this study is progression of SFN assessed by biopsy. disorders also defined as proteinopathies. activities planned for the period 2015-2017 in to assess the accuracy of the ultrasound-guided Another important objective of the LBN is the addition to the financing provided by the EOC. technique for the refill procedure, compared Main funding training and education of young scientists to foster to the blind technique in subjects undergoing Funding from private foundations and their career in basic and clinical research. As part Technologies regular refills of their intrathecal pumps for pharmaceutical companies (non-competitive of the scientific community, the LBN advocate The LBN research platform is a comprehensive the treatment of chronic non-malignant pain or funds). the exchange of know-how and data among approach based on electrophysiology, behavioural spasticity. national and international research team and the analysis, histology, flow cytofluorometry, confocal 2.9 Laboratory for Biomedical Neurosciences dissemination of our rationale and results through microscopy, and modern techniques in cellular d. Dorsal Root Ganglion Stimulation for the (LBN) specialized and general communication channels. and molecular biology, in order to analyze cellular Management of Painful Intractable Non- (Prof. Alain Kaelin MD, Paolo Paganetti PhD) A first experimental laboratory was created in and animal models of disease. Understanding diabetic Small Fibre Neuropathy in the Lower 2011 with the scope of promoting basic research the pathophysiology of Parkinson’s disease Limbs: A Prospective Case Series. The Laboratory for Biomedical Neurosciences in the field of translational neurosciences. In and the search of novel therapeutics based on Investigators: P. Maino, E. Koetsier, C. Gobbi, A. (LBN) is committed to discover new treatments September 2013, Dr. Paolo Paganetti took counteracting aberrant protein levels by targeting Kaelin. and diagnostics methods for patients affected by over the coordination and responsibility of the protein modification, misfolding and toxicity, are neurodegenerative disorders, a family of debilitating laboratory and in January 2014, Prof. A. Kaelin our everyday life. Background: Small fiber neuropathy (SFN) is a and irreversible disorders that significantly affect took over the responsibility for neuroscience disorder of the peripheral nerves that affects the life of patients and caregivers. research at the NSI. Together, they redefined Education thinly myelinated A Delta and unmyelinated C The integration of the LBN within the NSI - a the strategy of the LBN and created the LBN in Education and training at the LBN for young nerve fibers that painful symptoms typically centre of clinical excellence for the treatment of its current form. In March 2014, the LBN moved scientists interested in a career in basic and affect the limbs in a distal-to-proximal neurological and neurosurgical disorders - offers to a new research-dedicated facility at the Swiss translational research is granted by state of the gradient. Treatment of the painful symptoms the unique opportunity for a reciprocal fostering Institute for Regenerative Medicine (SIRM) in art infrastructure and excellent supervision which frequently fails. Spinal cord stimulation (SCS) between clinician-initiated basic research and Torricella-Taverne, Switzerland. Thanks to the help achieve an academic degree (master student, is used to treat chronic, intractable pain when translation of basic findings into new effective new laboratory space, the LBN has considerably Ph.D. student) or by widening and deepening their conventional therapies have failed and has therapies, to prevent and treat disease, as well grown in the last months. At the end of 2014, the scientific knowledge (postdoctoral and visiting been shown to be effective in patients having as innovative early diagnostic measures. This LBN was hosting ten scientists in three research fellows). a variety of neuropathic pain syndromes translational research aims at filling the gap often groups. With the envisaged integration into the Faculty including diabetic polyneuropathy. However, existing between discoveries by basic research Research of Dr. Paolo Paganetti takes a molecular of Biomedical Sciences and Master School of achieving good pain-paresthesia overlap of the and their application in medicine. Translational and cellular approach in order to investigate the Human Medicine of the University of Southern feet is noted to be challenging with conventional research addresses the challenge of applying new causes of neurodegenerative diseases such as Switzerland, the LBN will have the ability to assign spinal cord stimulation. discoveries into innovative techniques and tools Parkinson’s disease, Alzheimer’s disease, and a Ph.D. degree. In the meantime, PhD and Master Spinal cord stimulation of the dorsal root for diagnosis and treatment of human disease. Huntington’s disease. The research groups of students hosted at the LBN participate in the ganglion (DRG-SCS) is a relatively new Basic, translational and clinical research are Prof. Dr. Kaelin and Dr. Galati have successfully corresponding programs offered by national mode of SCS with promising results and complementary disciplines of biomedical sciences. created and implemented animal models for and international academic institutions, whilst has demonstrated pain relief for groin pain, The vision of the LBN is to improve the Parkinson`s disease, which are tailored for absolving their practical work within the LBN complex regional pain syndrome and chronic, understanding of neurodegenerative disorders behavioural and histopathological investigations research facilities as well as actively participating intractable neuropathic pain of the limbs and at the functional and molecular level. The LBN (Prof. Dr. Kaelin) as well as for electrophysiological in lectures, seminars and courses organized by trunk. The purpose of this study is to assess has established a research platform enabling studies (Dr. Galati). These research models have the LBN or by the LBN in collaboration with other the effectiveness of DRG-SCS in alleviating a comprehensive approach based on cellular found application in the understanding of the research institutes present in Ticino. Ph.D. and the painful symptoms in patients with non- and animal models of disease coupled with pathological mechanisms underlying these brain Master Students pursue their research projects

52 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 53 under the mentorship of experienced group The scope of the research is to understand the found in the brain of patients, affected by and association with multiple sclerosis. Hum Mol leaders and learn modern research technologies control mechanisms of movement. The project is neurodegenerative disorders, has established a Genet. 2014;23(4):942-948. and how to conduct a scientific research project aimed at defining the activity of some deep regions link between the sporadic and hereditary disease independently. The Ph.D. students hosted by the of the brain, the basal ganglia. They play a critical forms and has demonstrated the causative Ferri R, Cosentino FI, Manconi M, Rundo F, Bruni LBN in 2014 are affiliated with the University of role in the pathogenesis of various movement role of these proteins in the neurodegenerative O, Zucconi M. Increased electroencephalographic Berne or the University of Zürich. disorders such as Parkinson's and Huntington's process. These disorders are characterized by high frequencies during the sleep onset period diseases. Recent studies have indicated that the abnormal proteinaceous deposits in the brain in patients with restless legs syndrome. Sleep. Research group “Parkinson Disease” neural networks of the basal ganglia-thalamo- causing overt cell loss. The research group studies 2014;37(8):1375-1381. Lead investigator: A. Kaelin. cortical loop participate in everyday complex the molecular process that regulates protein Collaborators: G. Melli, A. Salvadé, S. Galati, S. behaviors that require coordination between misfolding, deposition and toxicity in cellular Galati S, Möller JC, Städler C. Ropinirole- Sgroi, F. Pandiani Cippà. cognition, motivation, and movements. The models of disease. In particular, we are interested induced Pisa syndrome in Parkinson disease. Clin Funding: external grants received in 2014 amount research is therefore aimed at understanding in characterizing post-translational modifications Neuropharmacol 2014; 37(2):58-9. to CHF 383’000 from the Swiss Parkinson the role and way of action of the basal ganglia- and subcellular localization of the proteins Foundation and IBRO/SSN. thalamo-cortical loop in normal behaviour and in involved in the pathogenesis of neurodegenerative Gobbi C, Rocca MA, Pagani E, Riccitelli GC, pathological states, such as Parkinson's disease disorders. Pravatà E, Radaelli M, Martinelli-Boneschi F, Parkinson’s disease (PD) is the second most and levodopa-induced dyskinesia. Falini A, Copetti M, Comi G, Filippi M. Forceps frequent neurodegenerative disorder with The research group creates animal models that Peer reviewed publications in 2014 (selection) minor damage and co-occurrence of depression most cases occurring after the age of fifty. The reproduce the clinical characteristics of early and Bersano A, Melchiorre P, Moschwitis G, Tavarini and fatigue in multiple sclerosis. Mult Scler. motor symptoms of PD result from the loss of advanced stages of Parkinson’s disease. The group F, Cereda C, Micieli G, Parati E, Bassetti C. Tako- 2014;20(12):1633-1640. dopaminergic neurons in specific regions of the can record the simultaneous extracellular and tsubo syndrome as a consequence and cause of brain. PD. A pathological characteristic of PD is the intracellular activity of several neurons in the basal stroke. Funct Neurol. 2014;29(2):135-137. Gobbi C, Rocca MA, Riccitelli G, Pagani E, Messina deposition of the protein alpha-synuclein in Lewy ganglia with local field potential, in anesthetized R, Preziosa P, Colombo B, Rodegher M, Falini A, bodies whose number and distribution directly and awake, normal, parkinsonian and dyskinetic Boulter DJ, Rumboldt Z, Bonaldi G, Muto M, Cianfoni Comi G, Filippi M. Influence of the topography relates to the clinical symptoms. Prolonged use rat models. A. Tilting the gantry for CT-guided spine procedures. of brain damage on depression and fatigue of dopamine-replacement therapies may lead to a Key Research Areas: Radiol Med. 2014;119(10):750-757. in patients with multiple sclerosis. Mult Scler. complication called dyskinesia. Levodopa-induced • Experimental dopamine-depleted animal Caulo M, Panara V, Tortora D, Mattei PA, Briganti C, 2014;20(2):192-201. dyskinesia is characterized by abnormal involuntary models. Pravatà E, Salice S, Cotroneo AR, Tartaro A. Data- movements (dystonia, chorea, athetosis). • Mechanisms underlying neuronal network driven grading of brain gliomas: a multiparametric Maestri M, Fulda S, Ferini-Strambi L, Zucconi Research at the LBN focus on the development activity in the basal ganglia. MR imaging study. Radiology. 2014. 272(2):494- M, Marelli S, Staedler C, Bassetti CL, Manconi of new animal models of the disease, e.g. to • The role of oscillations in cortico-basal ganglia- 503. M. Polysomnographic record and successful understand the pathophysiology of levodopa- thalamic loop function and dysfunction. Cianfoni A, Massari F, Dani G, Lena JR, Rumboldt management of augmentation in restless legs induced dyskinesia. Molecular studies aimed • The role of homeostatic plasticity on processing Z, Vandergrift WA, Bonaldi G. Percutaneous syndrome/Willis-Ekbom disease. Sleep Med. at understanding the molecular mechanisms of cortical input by the basal ganglia. ethanol embolization and cement augmentation of 2014;15(5):570-575. inducing alpha-synuclein-mediated toxicity. The aggressive vertebral hemangiomas at two adjacent purpose is also to use alphasynuclein analysis on Research group “Neurodegeneration” vertebral levels. J Neuroradiol. 2014;41(4):269- Maino P, Koetsier E, Perez RS. Fentanyl Overdose the skin as an early marker (see above, Movement Lead investigator: P. Paganetti. 274. Caused by Malfunction of SynchroMed II Intrathecal Disorders Centre). Collaborators: A. Salvadé, F. Pandiani Cippà, A. Pump: Two Case Reports. Reg Anesth Pain Med. Stuerchler, C. Foglieni, G. Ulrich. Di Lazzaro V, Giambattistelli F, Pravatà E, Assenza 2014;39(5):434-437. Research group “Basal Ganglia Pathophysiology” Funding: External grants received in 2014 G. Brachial palsy after deep sleep. J Neurol Lead investigator: S. Galati. amount to CHF 1,100,000 by the Gabriele Neurosurg Psychiatry 2014; 85(12):1409-1410. Manconi M, Ott S, Bassetti C. Integrating the Collaborators: A. Kaelin, A. Salvadé. Charitable Foundation, the Gelu Foundation, and review of Gottlieb et al. with the SAS-CARE Study. Funding: external grants received in 2014 amount an anonymous donor. Disanto G, Kjetil Sandve G, Ricigliano VA, Pakpoor Sleep. 2014;37(3):623-624. to CHF 343,000 from the Swiss Parkinson J, Berlanga-Taylor AJ, Handel AE, Kuhle J, Holden Foundation. The discovery of disease mutations in the genes L, Watson CT, Giovannoni G, Handunnetthi L, Manconi M, Zavalko I, Bassetti CL, Colamartino encoding for the proteins that form the deposits Ramagopalan SV. DNase hypersensitive sites E, Pons M, Ferri R. Respiratory-related leg

54 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 55 movements and their relationship with periodic leg enhancement: a rare magnetic resonance imaging document from Italian cardiological, surgical and Urol. 2014;191(3):697-702. movements during sleep. Sleep. 2014;37(3):497- finding in subacute spinal cord infarction. Spine J. anaesthesiological societies. EuroIntervention. 504. 2014;14(12):3065-3066. 2014 May;10(1):38-46. Zecca C, Riccitelli GC, Calabrese P, Pravatà E, Candrian U, Guttmann CRG, Gobbi C. Treatment Manconi M, Zavalko I, Cereda C, Pisarenco I, Ott S, Robert T, Duc C, San Millan Ruiz D, Morard Sgroi S, Kaelin-Lang A, Capper-Loup C. satisfaction, adherence and behavioural Fulda S, Bassetti CL. Longitudinal polysomnographic M. Solitary fibrous tumour with intramedullary Spontaneous locomotor activity and L-DOPA- assessment in patients de-escalating from assessment from acute to subacute phase component: case report and review of the induced dyskinesia are not linked in 6-OHDA natalizumab to interferon beta. BMC Neurol. in infratentorial versus supratentorial stroke. Literature. Neurol Neurochir Pol. 2014;48(2):144- parkinsonian rats. Front Behav Neurosci 2014; 2014;14:38-45. Cerebrovasc Dis. 2014;37(2):85-93. 149. 8:331. Awards 2014 Mordasini L, Kessler TM, Kiss B, Schüpbach M, Robert T, Martinez-Manas R, San Millan Ruiz D, Silveri MC, Pravatà E, Brita AC, Improta E, Ciccarelli Dominique Kuhlen: Pollo C, Kaelin-Lang A. Bladder function in patients Morard M. Cervical Intramedullary Metastasis N, Rossi P, Colosimo C. Primary progressive Executive Master in Business Administration with dystonia undergoing deep brain stimulation. from Cerebral Glioblastoma Multiforme. Clin aphasia: Linguistic patterns and clinical variants. and General Management of the University of St. Parkinsonism Relat Disord 2014; 20(9):1015- Neurol Neurosurg. 2014;123:61-63. Brain Lang. 2014; 135:57-65. Gallen (Executive MBA HSG), finished with success 1017. in May 2014. Rossini R, Musumeci G, Visconti LO, Bramucci Villa MP, Castaldo R, Miano S, Paolino MC, Vitelli Paganetti P, Antoniello K, Devraj K, Toni N, Kieran E, Castiglioni B, De Servi S, Lettieri C, Lettino M, O, Tabarrini A, Mazzotta AR, Cecili M, Barreto M. Claudio Gobbi: D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Piccaluga E, Savonitto S, Trabattoni D, Capodanno Adenotonsillectomy and orthodontic therapy in “Venia docendi” (PD title) from the University of Schrattenholz A, Liebner S, Havas D, Windisch M, D, Buffoli F, Parolari A, Dionigi G, Boni L, Biglioli F, pediatric obstructive sleep apnea. Sleep Breath. Basel in the field of Neurology in December 2014. Cirrito JR, Pfeifer A, Muhs A. Increased efflux of Valdatta L, Droghetti A, Bozzani A, Setacci C, Ravelli 2014;18(3):533-539. amyloid-β peptides through the blood-brain barrier P, Crescini C, Staurenghi G, Scarone P, Francetti Stefania Sgroi: by muscarinic acetylcholine receptor inhibition L, D'Angelo F, Gadda F, Comel A, Salvi L, Lorini L, Wesström J, Skalkidou A, Manconi M, Fulda S, • Travel grant from the “International Movement reduces pathological phenotypes in mouse models Antonelli M, Bovenzi F, Cremonesi A, Angiolillo DJ, Sundström-Poromaa I. Pre-pregnancy restless legs Disorders Society” to present a poster at the of brain amyloidosis. J Alzheimers Dis. 2014; Guagliumi G; Italian Society of Invasive Cardiology syndrome (Willis-Ekbom Disease) is associated MDS International Congress of Parkinson’s 38(4):767-786. (SICI-GISE); Italian Association of Hospital with perinatal depression. J Clin Sleep Med. 2014 Disease and Movement Disorders 2014, Cardiologists (ANMCO); Italian Society for Cardiac May 15;10(5):527-33. Stockholm, Sweden, 8th-12th June 2014 Pakpoor J, Goldacre R, Disanto G, Giovannoni Surgery (SICCH); Italian Society of Vascular and • Travel grant from the “Swiss Society for G, Goldacre MJ. Alcohol misuse disorders and Endovascular Surgery (SICVE); Italian Association Wu Y, Lucia K, Lange M, Kuhlen D, Stalla GK, Neuroscience” to present a poster at the multiple sclerosis risk. JAMA Neurol. 2014 of Hospital Surgeons (ACOI); Italian Society of Renner U. Hypoxia-inducible factor-1 is involved Society for Neuroscience Meeting 2014, Sep;71(9):1188-9. Surgery (SIC); Italian Society of Anaesthesia and in growth factor, glucocorticoid and hypoxia- Washington DC, USA, 15th-19th November Pignatti R, Bertella L, Scarpina F, Mauro A, Portolani Intensive Care Medicine (SIAARTI); Lombard mediated regulation of vascular endothelial growth 2014. E, Calabrese P. Italian version of the Parkinson Society of Surgery (SLC); Italian Society of factor-A in human meningiomas. J Neurooncol. Neuropsychometric Dementia Assessment Maxillofacial Surgery (SICMF); Italian Society of 2014;119(2):263-273. (PANDA): a useful instrument to detect cognitive Reconstructive Plastic Surgery and Aesthetics impairments in Parkinson's Disease. J Parkinsons (SICPRE); Italian Society of Thoracic Surgeons Zecca C, Digesu GA, Robshaw P, Puccini F, Kullar V, Dis. 2014;4(2):151-160. (SICT); Italian Society of Urology (SIU); Italian Society Tubaro, A, Gobbi C. Motor and sensory responses of Orthopaedics and Traumatology (SIOT); Italian after percutaneous tibial nerve stimulation (PTNS) Pollo C, Kaelin-Lang A, Oertel MF, Stieglitz L, Society of Periodontology (SIdP); Italian Federation in multiple sclerosis patients with lower urinary Taub E, Fuhr P, Lozano AM, Raabe A, Schüpbach of Scientific Societies of Digestive System Diseases tract symptoms treated in daily practice. Eur J M. Directional deep brain stimulation: an Lombardia (FISMAD); Association of Obstetricians Neurol. 2014;21(3):506-511. intraoperative double-blind pilot study. Brain. Gynaecologists Italian Hospital Lombardia (AOGOI); 2014; 137(7): 2015-2026. Society of Ophthalmology Lombardia (SOL). Zecca C, Digesu GA, Robshaw P, Singh A, ElNeil Perioperative management of antiplatelet therapy S, Gobbi C. Maintenance percutaneous posterior Pravatà E, Cereda C, Gabutti A, Distefano D, in patients with coronary stents undergoing nerve stimulation for refractory lower urinary tract Cianfoni A. Late-onset cauda equina contrast cardiac and non-cardiac surgery: a consensus symptoms in patients with multiple sclerosis. J

56 Scientific Report 2014 2. Neurocenter of Southern Switzerland (NSI) 57 3 EOC Multisite Departments and Services 3. EOC Multisite Departments and Services

The multisite Departments and Services are specific specialized skills of the Department, and is of the area of Lugano. are held at the University of Basel using cells structures that are transversal to all EOC institutes intended to be the best solution to harmonize and extracted from patient blood samples, normal and are an organizational model of clinical rationalize the facilities for surgery in the Canton. This study aims at evaluating the feasibility of and neoplastic colorectal mucosa. management. screening for abdominal aortic aneurysm in The Departments are, as a rule, the functional and Department of Surgery – Regional Hospital of male individuals of 65-80 years of age who • International Surgical Outcomes Study. organizational integration of operational units that Lugano are seen for other reasons at the various Participation in this multicenter international are homogeneous, similar, or complementary to outpatient clinics at the hospital of Lugano. transversal observational study that aims and mutually dependent on one another, sharing Main areas of research Patients are offered a screening ultrasound at assessing the actual incidence of post- the same goals – which could not be achieved The following studies are currently underway: examination and are included in a database. If operative complications after elective surgery otherwise. They are, however, clinically independent, the program proves to be feasible, its extension of all types. with their own separate professional responsibility. • Two surgical techniques for the treatment of to the other EOC hospitals will be considered. The Departments are made up of the relevant pilonidal sinus: a randomized controlled study. The recruitment was finalized this year and the Pre-, intra- and post-operative data were services, divisions and units, grouped according to data analysis is currently in progress. collected and submitted anonymously for all nosology, function and size. The needs for clinical This study compares the modified Karydakis patients operated during a predefined period governance are also taken into account in the technique (excision and lateral primary closure) • Isolation and characterisation of tumoural of 1 week. organization of the Departments. vs. simple fistulectomy for the treatment of stem cells in colorectal cancer. The study is led by Prof. M. Pearse from London, symptomatic pilonidal disease. The primary Collaboration in this project, led by the (Barts and the London School of Medicine and 3.1 EOC Department of Surgery endpoint is the % of patients healed at 3 weeks, University of Basel, as clinical consultants and Dentistry, Queen Mary University of London, Prof. Raffaele Rosso MD secondary endpoints are its total healing time, providers of human tissue. UK) with the participation of a large number of Head of Department of Surgery and the Regional infection rate, recurrence rate. The study centres across the world. Hospital of Lugano accrual has reached approximately 60% of the This study has the purpose to determine the The Surgery Department participated with total sample size. phenotype and function of tumour stem cells 11 cases. The study was approved by the The EOC Department of Surgery guarantees high- of colorectal cancer (CD133+), as well as “Kantonale Ethikkommission Kt. Zürich”. quality localized surgical assistance, either planned • Feasibility of an ultrasound screening program their interaction with T lymphocytes infiltrating or in emergency situations, making use of the for abdominal aorta aneurysm in the population the tumour. In vitro and in vivo experiments • Snapshot Diverticulitis: In-hospital management

60 Scientific Report 2014 3. EOC Multisite Departments and Services 61 of colonic diverticulitis in Switzerland. Nebiker C, Han J, Eppenberger-Castori S, Iezzi • Virtual reality interface and grip strength The sonographic examination is a useful Participation in this multicenter national G, Hirt C, Amicarella F, Cremonesi E, Huber X, measurement: experimental study. technique in the assessment of the follow-up transversal observational study that aims at Padovan E, Angrisani B, Droeser RA, Rosso R, Lead investigator: C. Fusetti. of patients undergoing surgical treatment for assessing the current practice in managing Bolli M, Oertli D, von Holzen U, Adamina M, Muraro In collaboration with: the “Laboratoire de cubital tunnel syndrome (CTS). Moreover, there the diverticular disease in Switzerland. MG, Memgus C, Zajac P, Sconocchia G, Zuber M, systèmes robotiques (LSRO)” (multidisciplinary is, a direct correlation between the values of Tornillo L, Terracciano L, Spagnoli GC. GM – CSF research unit working mostly in the fields of the cross section area (CSA) of the ulnar nerve Pre-, intra- and postoperative data were production by tumour cells is associated with robotics, micro-robotics and high-precision determined by sonographic examination and the collected and submitted anonymously for improved survival in colorectal cancer. Clin Cancer instrumentation): EPFL-STI-IMT-LSRO (H. clinical pre- and post-operative state in patients all patients admitted for medical or surgical Res. 2014;20(12):3094-106. Bleuler, M. Bouri), École Polytechnique Fédérale undergoing ulnar nerve decompression at the therapy of diverticular disease. The study was de Lausanne. elbow. The purpose of the study is to compare led by Prof. D. Hahnloser, from the University Reckhenrich AK, Kirsch BM, Wahl EA, Schenck the clinical results of open release and Hospital of Lausanne, CHUV. The Surgery TL, Rezaeian F, Harder Y, Foehr P, Machens HG, For our experiments on grip strength testing endoscopically assisted cubital tunnel release, Department participated with 19 cases. Egana JT. Surgical sutures filled with adipose- and detection of sub-maximal effort, we use an which encounter decompression of the ulnar The study was approved by the “Kantonale derived stem cells promote wound healing. PLOS instrumented dynamometer that was designed nerve at the elbow, using the differences Ethikkommission Kt. Zürich”. One. 2014; 9(3): e91169. using pieces of a non-functional Jamar found by sonographic examination of the cross dynamometer. Instead of a hydraulic-based section area (CSA) of the ulnar nerve, in search Main funding Hand Surgery Unit sensing device, we chose the piezoresistive for an association between the clinical results “Two surgical techniques for the treatment of Daniele De Spirito MD, technology for its reliability and its reproducibility and the CSA. pilonidal sinus: a randomized controlled study”: Regional Hospital of Lugano from one measurement to another. In order to ABREOC and the Research Fund of the Department Cesare Fusetti MD, keep the isometric measurement guaranteed Peer reviewed publications in 2014 of Surgery. Regional Hospital of Bellinzona and Valli by the hydraulic Jamar, we are using two force Corni V, Lucchina S, Fusetti C. Is Masson's tumour Stefano Lucchina MD, sensors so that the result is independent of only a slow-growing benign neoplasm? A case “Feasibility of an ultrasound screening program for Regional Hospital of Locarno where the subject applies his force on the report. Hand Surg. 2014;19(3):445-447. abdominal aorta aneurysm in the population of the Alain Thebaud MD, handle (isometric measurement). area of Lugano”: ABREOC. Regional Hospital of Mendrisio The outputs of the sensors go through Lucchina S, Fusetti C. A touch of humanity. Hands amplification and then are sent to the computer on stamps: Brazil 1979 - 150th Anniversary of the “Isolation and characterization of tumour stem The Hand Trauma Commission of FESSH HTC via the acquisition card. The signal is then used first publication in Braille Writing. J Hand Surg Am. cells in colorectal cancer”: University of Basel. intends to set up a database containing all major in one of the two interfaces. We plan to test 2014;39(2): 345. Trauma Centres in Europe. Based on the data the efficiency of these two interfaces to trick “International Surgical Outcomes Study” and submitted by the centres the Hand Trauma the patient. The Labview interface is directly Tröster B, Fusetti C. Is it necessary to remove “Snapshot Diverticulitis: In-hospital management Commission suggests centres to the national inspired by the "Visual Target Grip Test". the whole trapezium in thumb osteoarthritis. Ther of colonic diverticulitis in Switzerland”: no funding. representatives for accreditation. After validating Umsch. 2014;71(7):410-414. the data by the national representatives, accredited Clinical studies in progress: Peer reviewed publications in 2014 (selection) centres can receive a Diploma of Accreditation. (lead investigators: C. Fusetti; S. Lucchina): Humanitarian Mission Cristaudi A, Matthey-Gié ML, Demartines N, The EOC Hand Surgery Unit was accredited for GICAM ONLUS project 2014, surgical mission Christoforidis D. Prospective Assessment of the period 2014-2017 (contact person: C. Fusetti • Treatment of fractures of the fifth metacarpal (reconstructive microsurgery): Trocar-Specific Morbidity in Laparoscopy. World J MD, Regional Hospital of Bellinzona and Valli). neck by reduction and MCP-extension cast Surg, 2014;38(12):3089-3096. versus soft wrap/buddy taping: a prospective • Koforidua (Ghana), St. Joseph’s Catholic The EOC Hand Surgery Unit, together with hospital multicenter study. Hospital: C. Fusetti (surgeon, Regional Lee JT, Marquez TT, Clerc D, Gie O, Demartines and health service partners, provides diagnosis, In collaboration with HCUG of Geneva and Naval Hospital of Bellinzona and Valli), S. Lucchina N, Madoff RD, Rothenberger DA, Christoforidis treatment and rehabilitation services for upper Medical Centre of San Diego, CA-USA. (surgeon, Regional Hospital of Locarno), I. D. Pursestring closure of the stoma site leads to limb diseases and injuries. Anselmi (anesthesiologist, Regional Hospital of fewer wound infections: results from a multicenter • Sonographic follow-up of patients with cubital Bellinzona and Valli) randomized controlled trial. Dis Colon Rectum. Main areas of research tunnel syndrome (CTS) undergoing open neurolysis 2014;57(11):1282-1289. Experimental study in progress: in situ or endoscopy: a prospective study. • Machakos (Kenya), Bishop Kioko Catholic

62 Scientific Report 2014 3. EOC Multisite Departments and Services 63 Hospital: S. Lucchina (surgeon, Regional Bellinzona and Valli). Sponsor and Clinical Phase: Novartis The intense scientific activity is reflected in the Hospital of Locarno). Switzerland, Phase IIIb. large number of publications available at the • Swiss Cohort Atrial Fibrillation Study (Swiss AF website www.shcs.ch. 3.2 EOC Department of Internal Medicine Cohort). The aim of this study is to assess the efficacy, Prof. Augusto Gallino MD Lead investigator: D. Conen of the University safety and tolerability of intravenous infusion Main areas of research Head of the Department of Internal Medicine and Hospital of Basel. of 30 μg/kg/day serelaxin administered for • Th 17 cell migration and differentiation in HIV the Regional Hospital of Bellinzona and Valli. Main Coordinator and responsible for Southern 48 hours, when added to standard therapy infection (in collaboration with the IRB). Switzerland: A. Gallino (refer to chapter in patients hospitalized with acute heart Lead investigators: V. Cecchinato, E. The EOC Department of Internal Medicine is a of Cardiovascular Research Centre of the failure. Efficacy will be determined based on Bernasconi, R. Speck, M. Uguccioni. functional type of organizational structure, and Regional Hospital of Bellinzona and Valli). the combined primary endpoint of in-hospital is managed and coordinated by the Department worsening of heart failure requiring rescue CD4+ T-cell depletion, and in particular, Board. The rules adopted for its operation are Collaboration is also underway with the following therapy and all-cause deaths mortality through Th17 cell loss in the mucosal compartment, based on the fundamental principles of shared Swiss Hospitals and the Cardiocentro Ticino: day 5. Patients will be followed-up for 30 days. is a hallmark of HIV-1 infection in humans. clinical governance (accountability, participation, The purpose of this study is to generate clinical Alterations in the integrity of the mucosal transparency and management), and it is • Evidence Based Treatment in Heart Failure evidence, especially on the short term period (in- barrier have been indicated as a cause for organized using a multisite approach, offering a (EVITA-HF), Analysis of Iron Deficiency in Heart hospital and at 30 days) that will complement chronic immune activation and disease gateway to general internal medicine services. Failure (RAID-HF). existing and future serelaxin data sets in AHF. progression. Even though anti-retroviral therapy Moreover, it can advise and direct patients to the Lead investigator in Switzerland: O. Pfister of The study population will consist of male and (ART) can suppress plasma viral load, the appropriate reference centres. the University Hospital of Basel. female patients (≥18 years old) admitted to the immune activation persists in subjects on long- hospital for AHF, with systolic BP ≥125 mmHg term ART, and a complete T cell repopulation The EOC Department of Internal Medicine was Prospective Multicenter Registry conducted in and mild-to-moderate renal impairment. of the gut is rarely achieved. We showed that set up to ensure high-quality localized internal Austria, Germany and Switzerland, which aims CCR6+ and CXCR3+ T-helper cells accumulate medicine assistance, either planned or in at collecting data on clinical characteristics of Peer reviewed publications in 2014 in the blood of HIV-1-infected patients on long- emergency situations, making full use of its specific consecutive patients suffering from chronic Menafoglio A, Di Valentino M, Segatto JM, Siragusa term ART and weakly respond to chemotactic specialized skills, as the best way of harmonizing heart failure (CHF) with ejection fraction (EF) < P, Pezzoli R, Maggi M, Romano GA, Moschovitis G, stimuli. An inefficient polymerization of actin, and rationalizing the facilities for this sector in the 40 %, and to analyze medical and device therapy Wilhelm M, Gallino A. Costs and yield of a 15-month which leads to the reduction in cell migration, Canton. included ICD and CRT, mortality and non-fatal preparticipation cardiovascular examination is associated to cofilin hyper- activation in complications in-hospital and after one year with ECG in 1070 young athletes in Switzerland: circulating lymphocytes from HIV-1-infected Department of Internal Medicine, Cardiology follow-up and symptoms and re-hospitalization implications for routine ECG screening. Br J Sports patients, regardless of therapy. Service – Regional Hospital of Lugano (EVITA-HF Registry). In the Substudy data about Med. 2014;48(15):1157-61. In the further development of the study cited Giorgio Moschovitis MD the ferric state and hemoglobin and their in the previous scientific report, we point out Head of Service association with prognosis and quality of life of Department of Internal Medicine, Infectious the role of chronic immune activation via CHF, patients are collected (RAID-HF). Diseases Service – Regional Hospital of Lugano TLR7/8 triggering in the impairment of cell Main areas of research Prof. Enos Bernasconi MD migration. Cytoskeleton remodeling induced In collaboration with the Cardiovascular Research • Clinical Trial Protocol CRLX030A3301: A Deputy-Head of Internal Medicine by okadaic acid treatment, in vitro and in vivo, Centre of the Regional Hospital of Bellinzona and multicenter, prospective, randomized, open- restores lymphocyte migration, indicating that Valli: label study to assess the effect of serelaxin The Infectious Diseases Service (SMI) is a a pharmacological approach can be pursued in versus standard of care in acute heart failure specialized day clinic that deals with patients with order to achieve a better reconstitution of the • Tako-Tsubo Cardiomyopathy and Cardiac (AHF) patients (RELAX-AHF-EU). infectious diseases. The Service works in close mucosal compartments also in those patients Syndrome X: New Insights into the Lead investigator in Switzerland: Ph. Meyer of collaboration with local GPs. who are under long-term ART. pathophysiology of two orphan cardiac the University Hospital of Geneva. diseases. Local principal investigator: T. Moccetti of the The SMI is one of the seven reference centres • Rilpivirine entering the SWISS market of Lead investigators: M. Cattaneo, G. Moschovitis, CardiocentroTicino of Lugano. for the Swiss HIV Cohort Study (SHCS), one of the antiretroviral drugs: a 12-month evaluation. A. Gallino (refer to the chapter of Cardiovascular Local primary co-investigator: G. Moschovitis of world's largest epidemiological and clinical studies Lead investigators: D. Sculier, E. Bernasconi, A. Research Centre of the Regional Hospital of the Regional Hospital of Lugano. in the HIV field with more than 18'000 participants. Calmy.

64 Scientific Report 2014 3. EOC Multisite Departments and Services 65 The antiretroviral combination rilpivirine The Service of Infectious Diseases is also efavirenz with a common backbone. HIV Clin Trials. Main funding (RPV), tenofovir (TDF) and FTC (Eviplera®) was participating in a multicenter vaccine study: 2014;15(3):92-103. ABREOC. introduced into the Swiss drug market on 1st April 2013. It is only approved for HIV naive • Protocol GlycoVaxyn EC-4V. Young J, Wang Q, Fux CA, Bernasconi E, Furrer Peer reviewed publications in 2014 patients with a viral load ≤100,000 copies/ml H, Vernazza P, Calmy A, Cavassini M, Weber Caviezel S, Dratva J, Schaffner E, Schindler C, (Bulletin 15/13, Swiss Federal Office of Public A phase I study in 12 clinical sites in Switzerland R, Battegay M, Bucher HC, Swiss HIV Cohort Zemp Stutz E, de Groot E, Burdet L, Rothe T, Pons Health). Clinical experience suggests that the to assess a candidate vaccine against Study. The rate of recovery in renal function when M, Gaspoz JM, Rochat T, Künzli N, Probst-Hensch fixed dose combination is also prescribed uropathogenic Escherichia coli in women with patients with HIV infection discontinue treatment N, Schmidt-Trucksäss A. Sex-specific associations for HIV virologically suppressed experienced a clinical history of recurrent urinary tract with tenofovir. HIV Med. 2014;15(8):505-510. of cardiovascular risk factors with carotid patients either to reduce side effects due to the infection. stiffness--results from the SAPALDIA cohort study. current regimen or in simplification strategy. In 2014, we were able to include 22 patients Department of Internal Medicine, Internal Atherosclerosis. 2014;235(2):576-84. Data from the Swiss HIV Cohort Study show in this phase I study and we were among the 3 Medicine Service – Regional Hospital of Lugano that 349 patients were started on RPV/TDF/ best recruiting centres. The clinical milestone is Prof. Marco Pons MD Manconi M, Zavalko I, Bassetti CL, Colamartino FTC between 1st April to 1st December 2013, linked to the achievement of a robust immune Head Doctor E, Pons M, Ferri R. Respiratory-related leg and among them, only 18 (5%) patients were response against all antigens included into the movements and their relationship with periodic leg started RPV/TDF/FTC as a first-line regimen. vaccine candidate at 30-day post-vaccination. Main areas of research movements during sleep. Sleep. 2014;37(3):497- We aim at assessing (i) the indications for We hope for a further development of the Sleep-disordered breathing in patients with 504. which RPV is prescribed among HIV patients candidate vaccine with the possibility for our ischemic stroke: clinical, prognostic and within the Swiss HIV Cohort Study in the first centre to participate in a phase III study. pathophysiological aspects. Pastori MM(*), Sarti M(*), Pons M, Barazzoni F. 12 months after it entered the Swiss Market, Lead investigator: M. Pons. Assessing the impact of bibliographical support on (ii) the effect of switch to RPV/TDF/FTC Main funding Co-investigators: A. Riglietti, A. Azzola. the quality of medical care in patients admitted to among experienced HIV patients on common SHCS (through SNSF), Infectious Diseases an internal medicine service: a prospective clinical, side effects (iii) early safety and efficacy data Research Fund, pharmaceutical industry. The respiratory disorders during sleep (SDB) are open, randomised two-arm parallel study. Evid of RPV under routine clinical care conditions, a frequent problem among patients with a first Based Med. 2014;19(5):163-168. comparing data with patients on a fixed dose Peer reviewed publications in 2014 (selection) ischemic cerebrovascular event. 40% of patients (*) MMP and MS contributed equally. combination of EFV/TDF/FTC (Atripla®). The Kouyos RD, Rauch A, Böni J, Yerly S, Shah C, with SDB, which occurred during the acute phase study was carried out in 2014, and the results Aubert V, Klimkait T, Kovari H, Calmy A, Cavassini of a stroke, has a breathing pattern characterized Department of Internal Medicine, Pneumology should be available in early 2015. M, Battegay M, Vernazza PL, Bernasconi E, by central apnea and/or periodic breathing, Service – Regional Hospital of Lugano Ledergerber B, Günthard HF; the Swiss HIV isolated or associated with obstructive apneas, Andrea Azzola MD FCCP • The Swiss HIV Cohort Study Core Project Cohort Study. Clustering of HCV coinfections whose pathogenesis and clinical relevance in Head of Service Metabolism and Aging (M + A core project). on HIV phylogeny indicates domestic and terms of impact on morbidity and mortality in the Lead investigator: P. Tarr (in Lugano: E. sexual transmission of HCV. Int J Epidemiol. long term, is still largely unknown. Main areas of research Bernasconi). 2014;43(3):887-96. The assumption which underlies the present study • INPUT on PE: multicenter, observational is that an alteration in the autonomic system is screening survey for the detection of chronic This ongoing study has already been described Regoes R, McLaren P, Battegay M, Bernasconi the cause for central apneas that are frequently thromboembolic pulmonary hypertension in the previous report. The aim is to assess E, Calmy A, Günthard H, Hoffmann M, Rauch A, observed in the acute phase of a cerebral (CTEPH) following pulmonary embolism. morbidity of HIV-infected patients outside Telenti A, Fellay J and the Swiss HIV Cohort Study. ischemic event. In particular, an alteration in the (Multicentric Swiss Study). the classic opportunistic diseases. In fact, Disentangling human tolerance and resistance baroreflex and chemoreflex, expression of a state Lead investigator: JD. Aubert, CHUV, Lausanne. premature aging with cardiovascular and against HIV. PLoS Biol. 2014;12(9):e1001951. of activation of the sympathetic nervous system, Local Co-investigator and member of the cerebrovascular disease, osteoporosis, could be a causal factor in the genesis of SDB, steering committee: A. Azzola. neurocognitive dysfunction, diabetes mellitus, Wang Q, Young J, Bernasconi E, Vernazza P, as well as an independent risk factor for cerebral Patients with PE who are included in the survey lipodystrophy, and other morbid conditions are Calmy A, Cavassini M, Furrer H, Fehr J, Bucher ischemic events. Their joint study will provide useful will be followed by regular telephone contacts increasingly important determinants of the HC, Battegay M and the Swiss HIV Cohort Study. elements of pathophysiological clarification. at months 6, 12 and 24 using a particular long-term health of HIV infected individuals. Virologic and immunologic responses in treatment- dyspnea questionnaire. If specific symptoms naïve patients to ritonavir-boosted atazanavir of of dyspnea are reported, patients will be

66 Scientific Report 2014 3. EOC Multisite Departments and Services 67 invited to the study centre within 4 weeks for beta agonist (LABA) vs. single bronchodilatation Head Doctor gland. confirmation of dyspnea and, if dyspnea is with LABA in symptomatic moderate to severe Primary objective: to demonstrate that confirmed, an echocardiography and further COPD patients with current or past smoking Main areas of research treatment with AMG 416 is not inferior to diagnostic workup are carried out. The study history. • DialysIS (Dialysis therapy between Italy and treatment with cinacalcet to lower serum ends when data of 1000 evaluable patients are Primary objective: To demonstrate the Switzerland). intact PTH levels by >30%. collected. superiority of a single-dose of the combined Lead investigators: ML. Costantino (Politecnico Secondary objective: to assess whether Primary Endpoint: To evaluate the incidence inhalation of QAB149 150μg and NVA237 of Milan), F. Locatelli (Hospital of Lecco), G. treatment with AMG is superior to treatment rate of symptomatic CTEPH at 6, 12 and 50μg vs. QAB149 alone regarding the Pontoriero (Hospital of Lecco), C. Schönholzer with cinacalcet as measured by the mean days 24 months after confirmed PE. Secondary Inspiratory Capacity (IC) peak value. Key (Regional Hospital of Lugano), G. Bonforte of vomiting or nausea per week, proportion Endpoints: a) Comparison of the baseline Secondary Objective: To compare the efficacy (Hospital of Como), G. Rambola (Hospital of of subjects with >50% decrease in serum parameters of the patients who developed of the combined inhalation of 150μg QAB149 Varese). iPTH, change from baseline of serum calcium, CTEPH with the patients who did not develop and 50μg NVA237 vs. 150μg QAB149 alone Phase 1 of study: Politecnico of Milan, Hospital mean pre-dialysis phosphorus, mean severity CTEPH after PE to identify any risk factors. regarding FEV1 over 4h after dosing. Other of Lecco and Regional Hospital of Lugano; of nausea and mean episodes of vomiting per B) Comparison of the results of the dyspnea Secondary Objectives: to compare the efficacy Phase 2 of study: Politecnico of Milan; week. questionnaire answered by telephone with the of the combined inhalation of 150μg QAB149 Phase 3 of study: Politecnico of Milan, Hospital Treatment time: 26 weeks. dyspnea evaluation by the investigator at the and 50μg NVA237 vs. 150μg QAB149 of Lecco, Regional Hospital of Lugano, Hospital Sample: 600 patients, approximately 300 in clinic. alone regarding the Inspiratory Capacity (IC), of Como and Hospital of Varese. each treatment group (Europe, USA, Russia, A steering committee (constituted by SSPH Forced Volume Capacity (FVC), Total Lung AUNZ); 30 patients in CH (Genève, Lausanne, members and PE experts) will be responsible Capacity (TLC) and Airway Resistance (Raw) Multicenter Study. The purpose of the study is Basel, Zürich, Locarno, Lugano). for the supervision of the survey, data collection over 4h after dosing (30min, 60min, 120min, to develop a computer model that may allow Start: 1.10.2013: 1 patient recruited at and analysis, as well as the publication of 180,min,240min) after dosing. a more accurate planning of the hemodialysis Lugano. results. Recruitement phase: October 2012 – treatment. In the first phase (9 months), for Recruitment phase: closed 2014. September 2014. 70 hemodynamically unstable patients (20 Main funding Follow up: ongoing. Data analysis: ongoing. Results publication: patients with 8 dialysis treatments in Lugano, “DialysIS (Dialysis therapy between Italy and Study closure: expected 2016. expected 2015. 50 patients with 6 dialysis treatments in Switzerland)”: INTERREG (Programma Operatorio Lecco), and many parameters are registered di Cooperazione Transfrontaliera Italia-Svizzera/ • SYNERGY Study: a multicenter, randomized, Peer reviewed publications in 2014 to develop an individualized profile of each Cooperazione Territoriale Europea) (“Surgical double-blind, single-dose study to assess the Kern L, Condrau S, Baty F, Wiegand J, van Gestel patient. In the second phase, (9 months) Cross-Border Cooperation Programme Italy- effect of the combined inhalation of 150µg AJ, Azzola A, Tamm M, Brutsche M. Oxygen a computer model will be developed and Switzerland/European Territorial Cooperation” - Indacaterol maleate (QAB149) and 50µg kinetics during 6-minute walk tests in patients with refined by the Politecnico of Milan. In the third external competitive grant). Whole project: more glycopyrronium bromide (NVA237) versus cardiovascular and pulmonary disease. BMC Pulm phase (9 months), the clinical behaviour of than 1 Mio CHF; Nephrology and Haemodialysis inhaled 150µg Indacaterol maleate (QAB149) Med. 2014;14:167. hemodynamics during the dialysis sessions and Service of Regional Hospital of Lugano: CHF alone on inspiratory capacity in patients with the quality of life of patients in all four clinical 118'000. moderate or severe COPD. Kutz A, Grolimund E, Christ-Crain M, Thomann R, centres will be documented before and after (Multicentric Swiss Study). Falconnier C, Hoess C, Henzen C, Zimmerli W, the implementation of the computer model. “A Multicenter, Multiple-dose, Two-arm, Active- Lead investigator: M. Brutsche, KSSG, St. Mueller B, Schuetz P; ProHOSP Study Group (*). controlled, Double-blind, Double-dummy Study to Gallen. Pre-analytic factors and initial biomarker levels in • A Multicenter, Multiple-dose, Two-arm, Active- Compare the Therapeutic Efficacy and Safety of Local Co-investigator and member of the community-acquired pneumonia patients. BMC controlled, Double-blind, Double-dummy Study Oral Doses of Cinecalcet HCl with Intravenous steering committee: A. Azzola. Anesthesiol. 2014;14:102. to Compare the Therapeutic Efficacy and Safety Doses of AMG 416 in Hemodialysis Subjects (*) Azzola A as member of the ProHOSP Study Group of Oral Doses of Cinecalcet HCl with Intravenous with Secondary Hyperparathyroidism”: Amgen Synergy is a Swiss multicenter, randomized, Doses of AMG 416 in Hemodialysis Subjects (external grant, competitive only for recruitment double-blinded, single-dose, cross-over, placebo- Department of Internal Medicine, Nephrology with Secondary Hyperparathyroidism. of patients); approximately CHF 9'000 per patient. controlled study, evaluating the effects of dual and Haemodialysis Service – Regional Hospital bronchodilatation with inhalation of long-acting of Lugano Phase III study: AMG 416 is a calcium receptor Department of Internal Medicine, muscarinic agonist (LAMA) and long-acting Carlo Schönholzer MD stimulating agent at the level of the parathyroid Cardiovascular Research Centre – Regional

68 Scientific Report 2014 3. EOC Multisite Departments and Services 69 Hospital of Bellinzona and Valli contrast ultrasounds and plaque magnetic Collaborators: M. Di Valentino, G. Moschovitis. Coronary Risk Evaluation. Athletes with Prof. Augusto Gallino MD resonance (HR-MRI): ”In Vivo” comparison in Swiss-AF is a large project at national level abnormalities at screening or with a high Head of Department and Head Doctor human carotid atherosclerosis. and is the continuation of the BEAT-AF Study risk, are submitted to additional cardiac Lead investigator: A. Gallino. and aims at assessing the major complication examinations. However, there are very few Main areas of research Collaborators: R. Wyttenbach, M. Cattaneo, of atrial fibrillation. One of the main points data on the impact of such a stance. • Tako-Tsubo Cardiomyopathy and Cardiac AP. Porretta, M. Stuber (CHUV, Lausanne). of the study is the occurrence of silent The purpose of this study was to provide a yield Syndrome X: New Insights into the cerebral ischemia, which will be prospectively and cost-analysis of this preventive evaluation. pathophysiology of two orphan cardiac This project is a continuation of the over 10-year evaluated by serial cerebral MRI as well as by The analysis of the data was completed and diseases. research on progression of atherosclerosis neuropsychological testing. the data/results were presented at the Euro- Lead investigators: AP. Porretta, M. Cattaneo, performed at our Cardiovascular Research This multicenter national prospective clinical Prevention Annual Meeting of the European G. Moschovitis, A. Gallino. Centre and aims at evaluating the role of project has been recently endorsed by the Society of Cardiology in Dublin (spring 2014), plaque neo-vascularisation in the progression Swiss National Foundation. The BEAT-AF Study as well at the annual meeting of the European This project aims at evaluating the possible of atherosclerosis at the level of the carotid which has been the platform for the current Society of Cardiology in Barcelona (both as oral pathophysiological mechanisms inducing artery. It is a joint project between the national program, has included several hundred communications). two orphan diseases: Cardiac Syndrome X Cardiovascular Research Centre, the Radiology of patients. So far, almost 400 patients have A manuscript with the study results was and Tako-Tsubo Syndrome. Both diseases Division of the Hospital of Bellinzona, and the been included in the multicenter cohort study; submitted to a journal by the P.I. Dr. Andrea affect almost exclusively middle aged women. Cardiovascular Imaging Research Centre at among them, over 25 patients have been Menafoglio and the manuscript was accepted Prognosis of the diseases is better than in CHUV as well as with Prof. C. Yuan, University included in Canton Ticino. and already published online in the Br J Sports patients with trivial coronary artery disease of Seattle. The project is also performed in Med. 2014 Nov 13. pii: bjsports-2014-093857. and worse than in the normal corresponding cooperation with Prof. Daniel Staub, chief of the • Impact of cardiovascular screening in middle- doi: 10.1136/bjsports-2014-093857. population. We assess the autonomic function vascular Division at University Hospital in Basel. aged athletes (35 to 65 years old). as well as endothelial vascular function at Almost 40 patients have been screened as Lead investigator: A. Menafoglio. • Triggers of myocardial infarction two month rest and after standardized mental stress. All possible candidates for this prospective study. Collaborators: M. Di Valentino, P. Siragusa, G. before the acute event. Study on preventive scheduled patients were included in the study. Several technical issues concerning dynamic Moschovitis. cardiology: TAMI-Study. Baroreflex test (BRS) and endothelial function assessment of plaque vascularisation in order Lead investigator: M. Di Valentino. tests were performed. Arterial pulse wave to obtain top images are now undergoing a Regular physical exercise reduces velocity measurements will be performed from double check at the University in Seattle, USA cardiovascular morbidity and mortality. The vast majority of acute myocardial February 2015 to June 2015, according to the (Imaging centre for Atherosclerosis). However, vigorous physical exertion may infarctions are caused by an acute occlusion accepted amendment of the project submitted So far, 29 patients have been included in the trigger adverse cardiovascular events in the of the coronary branch. Frequently this to the Ethics Committee. study; MRI plaque imaging was insufficient to presence of underlying heart diseases. In atherothrombotic occlusion is preceded by We are in the process of analysing, together obtain a reliable comparison with the contrast middle-aged individuals (35 to 65 years old) atherosclerotic plaque instability. Endothelial with a leader in the field of endothelial function enhanced duplex ultrasounds examination in 7 coronary artery disease is the principal cause function plays a major role immediately and measurement of autonomic nervous patients. A blinded head to head comparison of cardiac events during sports. A screening before and after the acute atherothrombotic system (PD. Dr. Isabella Sudano, USZ, Zurich), between the Cardiovascular Research Unit examination has the potential to detect still occlusion. Cardiac rehabilitation is a non- the results of the BRS and endothelial function (CEUS) data and the plaque MRI evaluation, as asymptomatic individuals with heart diseases pharmacological intervention which is known evaluations. well as contrast-enhanced neovascularization and to protect them from cardiac events when to improve endothelial function. The objective The results will be hopefully submitted for MRI assessment, will be performed in June playing sports. of this study is to investigate on the possible the forthcoming 2015 European Society 2015 at our CEUS, at the Angiology Division The European Association of Cardiovascular triggers preceding the acute atherothrombotic Cardiology (ESC) Meeting and American of the University of Basel and the Vascular Prevention and Rehabilitation has recently complication, using dedicated questionnaires Heart Association (AHA) Meeting 2015. A Research Centre in Seattle, USA. edited the recommendations about to patients having had a recent acute manuscript will be probably submitted to an cardiovascular screening of middle-aged myocardial infarction and following a important cardiovascular journal in autumn • Swiss Cohort Atrial Fibrillation study "Swiss-AF". individuals participating in sporting activities. rehabilitation program. Furthermore, the study 2015. Lead investigator: D. Conen. The screening consists of history, physical aims at evaluating the endothelial function at Main Coordinator and responsible for Southern examination, resting electrocardiogram and the beginning, and at the end of the cardio- • Plaque neovascularization assessment by Switzerland: A. Gallino. risk stratification according to the Systematic rehabilitation. The project includes patients

70 Scientific Report 2014 3. EOC Multisite Departments and Services 71 with previous acute myocardial infarction and a Non-Coronary Atherosclerosis. Eur Heart J. factors, linked to the fragility of the patients and/ • Vascular aging in haemodialysis patients: a control cohort of patients. So far, 100 patients 2014;35(17):1112-1119. or dialysis, which are likely to affect the degree prospective study. have been included in the study, and we are of mobility and independence in everyday life, the Lead investigator: L. Gabutti. finalizing the inclusion of the control patients. Konieczka K, Ritch R, Traverso CE, Kim DM, Kook balance and walking control of the patients, as well We are in the process of including the last MS, Gallino A, Golubnitschaja O, Erb C, Reitsamer as the danger of a fall. In a cohort study involving 4 EOC dialysis units, patients of the control cohort. The analysis HA, Kida T, Kurysheva N, Yao K. Flammer the pulse wave velocity and the main risk of the results is scheduled by the end of Syndrome. Main funding factors for cardiovascular diseases have been September 2015. EPMA J. 2014;5(1):11. ABREOC. monitored prospectively for 2 years.

Main funding Menafoglio A, Di Valentino M, Segatto JM, Peer reviewed publications in 2014 • Coagulation activation using different haemodi- "Tako-Tsubo Cardiomyopathy and Cardiac Siragusa P, Pezzoli R, Maggi M, Romano GA, Albani M, Balestra B. Therapierefraktäre alysis membranes. Syndrome X: New Insights into the pathophysiology Moschovitis G, Wilhelm M, Gallino A. Costs and Beinödeme, Hypertonie und Niereninsuffizienz. Lead investigator: L. Gabutti. of two orphan cardiac Disease": ABREOC. yield of a 15-month pre-participation cardiovascular Forum Med Suisse 2014;14(38):706-708. examination with ECG in 1070 young athletes In a randomised controlled cross-over study, "Swiss Cohort Atrial Fibrillation study": SNSF, in Switzerland: implications for routine ECG Anichini A, Balestra B. La thalidomide: retour vers the activation of the coagulation using 3 Swiss Heart Foundation Research (Grant Number: screening. Br J Sports Med. 2014;48(15):1157- le futur. Forum Med Suisse 2014;14(24):467- different dialysis membranes was analyzed. 33CS30_148474/1). 61. 469. • Citrate pre-and post-filter: a randomized "Plaque neovascularization assessment by contrast Department of Internal Medicine – Regional Guggiari U, Balestra B. Das Reynolds-Syndrom. controlled trial in a population in chronic ultrasounds and plaque magnetic resonance Hospital of Mendrisio Forum Med Suisse 2014;14(8):156-157. haemodialysis. (HR-MRI): “In Vivo” comparison in human carotid Brenno Balestra MD Lead investigator: L. Gabutti. atherosclerosis": Swiss Heart Foundation Research Head Doctor Department of Internal Medicine – Regional Grant. Hospital of Locarno In a randomized controlled cross-over study, The Internal Medicine Service of the Regional Prof. Luca Gabutti MD the consequences on the quality of dialysis "Triggers of myocardial infarction two month Hospital of Mendrisio is one of the many Services Head Doctor of Internal Medicine and Nephrology following the use of citric acid in the dialysate before acute event": Swiss Heart Foundation that make up the EOC’s multisite Department of Service of Regional Hospital of Locarno and were examined. Research. Internal Medicine. Coordinator of the EOC’s Nephrology and Haemodialysis Services • Temperature of the dialysate and haemody- "Impact of cardiovascular screening in middle- Main areas of research namics: a randomized study. aged athletes (35 to 65 years old)": ABREOC. Influence of hemodialysis on physical activity and The head of the Internal Medicine and Nephrology Lead investigator: L. Gabutti. motor skills in patients with stage V chronic renal Service of the Regional Hospital of Locarno is Biotronik Switzerland: unrestricted research grant. insufficiency (K/DOQI). the Coordinator of the network that groups the In a randomized controlled cross-over study, Lead investigators: O. Giannini, C. Cereghetti, P. nephrology services of the EOC’s four regional the haemodynamic consequences of changing Medtronic Switzerland: unrestricted research grant. Quadri. hospitals. The organisation is aimed at ensuring the temperature of the dialysate were analyzed. that medical and nursing care is of a high quality, AstraZeneca Switzerland: unrestricted research This is a prospective multicenter observational and also that the skills of the specialists are • Hypokalemia in hospitalized patients – a multi- grant. study carried out among an outpatient population capillary available. level challenge amidst inefficiency, reported of at least 30-50 patients with chronic renal severity and actual severity Peer reviewed publications in 2014 insufficiency (CKD 5, in line with K/DOQI) who were Main areas of research Lead investigator: L. Gabutti. Gallino A, Aboyans V, Diehm C, Cosentino F, about to receive dialysis at the Haemodialysis and • Swiss Salt Study: secondary analyses of the Stricker H, Falk E, Schouten O, Lekakis J, Amann- Nephrology Service day centres or private dialysis data. In a survey, the incidence and risk factors of Vesti B, Siclari F, Poredos P, Novo N, Brodmann M, centres in Ticino. The purposes of the study are Member of the working group: L. Gabutti. Hypokalemia in EOC hospital inpatients were Schulte KL, Vlachopoulos C, De Caterina R, Libby to: quantify the changes in the overall level of analysed. An interventional phase is ongoing. P, Baumgartner I; European Society of Cardiology mobility and the postural and walking strategies Several secondary analyses of the data from Working Group on Peripheral Circulation. that accompany entry into dialysis, highlight the “Swiss Salt Study” are currently underway. • Magnesium in the dialysate and

72 Scientific Report 2014 3. EOC Multisite Departments and Services 73 haemodynamics. comprises the relevant services in the Hospitals Unit. Crit Care Res Pract. 2014;2014:203637. Department of Laboratory Medicine) and L. Lead investigator: L. Gabutti. of Bellinzona, Lugano, Mendrisio and Locarno. The doi:10.1155/2014/203637. Giovanella (EOC Nuclear Medicine Service and Department has a functional type of organizational PET/CT Centre). The study aims at analyzing the haemodynamic structure and is managed and coordinated by Perren A, Merlani P. The difficulty of measuring consequences of changes in the concentration the Department Board. The rules adopted for its the measurable. Respir Care. 2014;59(7):1155- Thyroid carcinoma is the most frequent of magnesium in the dialysate. functioning are based on the fundamental principles 1156. endocrine tumour. 90% of thyroid carcinoma of shared clinical governance (accountability, are represented by papillary and follicular Main funding participation, transparency and management), Perren A, Cerutti B, Merlani P, Perren I, carcinoma that are commonly defined as All projects were funded by Balli and Gianella and it is organized using a multisite approach. Previsdomini M, Massarotto P, Kaufmann M, differentiated thyroid carcinomas (DTC). foundations. Here, too, the creation of the EOC Department of Rothen HU. SwissScoring - a nation-wide survey of Diagnosis of DTC includes TSH-measurement, Intensive Care Medicine was aimed at providing the NEMS assessing practices and its accuracy. Acta thyroid ultrasound and thyroid scintigraphy Peer reviewed publications in 2014 most suitable response to the need to harmonize Anaesthesiol Scand. 2014;58(4):478-486. as well as fine-needle-aspirate of the most Bianchi G, Salvadé V, Lucchini B, Schätti-Stählin and rationalize the services offered in this sector suspected lumps for cytology. Treatment S, Salvadé I, Burnier M, Gabutti L. Assessment of in our Canton. Previsdomini M, Cerutti B, Merlani P, Kaufmann of these types of carcinoma includes total subjective and hemodynamic tolerance of different M, van Gessen E, Rothen HU, Perren A. thyroidectomy as well as thyroid-residual high- and low-flux dialysis membranes in patients Department of Intensive Care Medicine – SwissScoring - a nation-wide survey of SAPS II ablation with I-131. The prognosis is good; undergoing chronic intermittent hemodialysis: A Regional Hospital of Bellinzona and Valli assessing practices and its accuracy. Swiss Med however, 20-30% of patients develops a local/ randomized controlled trial. Hemodial Int. 2014; Andreas Perren MD PD Wkly. 2014;144:w14090. metastasis relapse. It is, therefore, crucial to 18: 825-834. Head Doctor propose a long-term follow-up that includes 3.4 Department of Laboratory Medicine monitoring of specific tumour markers like, Guessous I, McClellan W, Kleinbaum D, Vaccarino V, Main areas of research Franco Keller MD e.g., the thyroglobulin molecule. Today, new Zoller O, Theler JM, Paccaud F, Burnier M, Bochud Physical restraint in the ICU: psycological Head of Department promising markers, such as BRAF-mutations M. Swiss Survey on Salt Group. Comparisons of consequences. and hTSHR seem to be more sensitive in the Serum Vitamin D Levels, Status, and Determinants Lead investigators: A. Perren, E. Iapichino, D. The Department of Laboratory Medicine (EOLAB) detection of relapsing disease. The purpose in Populations With and Without Chronic Kidney Corbella, R. Malacrida, A. Verdi. was set up to meet the needs of modern medicine of this study is to evaluate the analytical Disease Not Requiring Renal Dialysis: A 24-Hour as regards laboratory services, and also because superiority of these new markers by comparing Urine Collection Population-Based Study. J Ren This multicenter study was planned to depict the of the need to minimize costs and make a more the classical approach to detect relapsing Nutr. 2014;24(5):303-312. clinical scenario of physical restraint practice rational use of resources, including increasingly disease. in adult ICUs and to analyse the relationship sophisticated and expensive equipment. Ogna A, Forni Ogna V, Bochud M, Paccaud F, between its use and the occurrence of adverse Although EOLAB operates in different parts of • Improving the diagnosis of late onset Gabutti L, Burnier M. Swiss Survey on Salt events. A second purpose was to investigate the the Ticino Canton, it has a centralized location hypogonadism. Group. Prevalence of obesity and overweight and psychological outcome after physical restraint. for its technical, scientific and administrative Lead investigators: M. Imperiali (EOC associated nutritional factors in a population- While the first part of the study has already been services, thus giving the whole Department a Department of Laboratory Medicine), G. based Swiss sample: an opportunity to analyze the finalized, and the manuscript submitted to a peer- unified image. This form of organization also offers Montagna (Gynaecology and Obstetrics impact of three different European cultural roots. reviewed journal, the second part is still ongoing greater potential for a rational development. Service, Regional Hospital of Lugano) and L. Eur J Nutr. 2014;53(5):1281-1290. and is likely to be completed by the end of 2015. The Department is the result of an innovative Giovanella (EOC Nuclear Medicine Service and project, which also arouses interest outside the PET/CT Centre). 3.3 EOC Department of Intensive Care Main funding Ticino Canton, and can be considered one of the Medicine ABREOC. major public institutions of medical analysis in The testes produce the testosterone (T) in men, Paolo Merlani MD PD Switzerland. and its levels increase from puberty to adulthood Head of the EOC Department of Intensive Care Peer reviewed publications in 2014 and then, progressively decline starting by Medicine and Head Doctor in the Regional Hospital Bonassin TF, Rudiger A, Previsdomini M, Maggiorini Main areas of research the fourth or fifth decade of life. Symptoms of Lugano M. Platelet Consumption an Filter Clotting Using • Studio marcatori biochimici tiroidei (Study of of hypogonadism are highly nonspecific and Two Different membrane Sizes during Continuous thyroid biochemical markers). include decreased libido, erectile dysfunction, The EOC Department of Intensive Care Medicine Venovenous Haemodiafiltration in the Intensive Care Lead investigators: M. Imperiali (EOC decreased volume of ejaculate, loss of body

74 Scientific Report 2014 3. EOC Multisite Departments and Services 75 and facial hair, decreased lean body mass, Ramelli V, Ramelli GP, Lava SA, Siegenthaler GM, MD for genetic projects. cognitive development in children with rolandic increased body fat, fatigue and weakness. It is Cantù M, Bianchetti MG, Ceschi A. Vitamin D status The research unit is coordinated by Prof. Dr. epilepsy. sometimes challenging to discriminate these among children and adolescents on anticonvulsant Mario G. Bianchetti MD. (in collaboration with the University Children’s symptoms from those resulting from aging drugs in southern Switzerland. Swiss Med Wkly. Dr. Valdo Pezzoli MD is the Head Doctor of Hospital of Basel). per se. For this reason, the concept of late- 2014;144:w13996. Paediatric Service of Regional Hospital of Lugano Lead investigator: GP. Ramelli. onset hypogonadism (LOH) was introduced. and the president of the Swiss Society for LOH is defined as a total testosterone level Reynaldos Canton Migotto T, Györik Lora S, Gaia Biomedical Ethics. • Diagnosis and management of hereditary salt- < 11 nmol/L combined with the presence of V, Pagnamenta A. ARDS with septic shock due to losing tubular disorders. three sexual symptoms: decreased frequency Legionella longbeachae pneumonia in a patient Main areas of research (in collaboration with the University Children’s of morning erection, erectile dysfunction and with polymyalgia rheumatica. Heart Lung Vessel. • Arterial stiffness among children and Hospital of Milan and the Merate-Lecco decreased frequency of sexual thoughts. 2014;6(2):114-118. adolescents a. with overweight or b. with Hospital). Although accepted by all andrology societies, chronic diseases (asthma and inflammatory Lead investigator: MG. Bianchetti. the cut off of 11 nmol/L does not consider Trellu LT, Oertle D, Itin P, Furrer H, Scheidegger bowel diseases). the differences that exist between different C, Stoeckle M, Schmid P, Bernasconi E, Cavassini Lead investigator: GD. Simonetti. Projects currently underway: a. Parental analytical platforms. M, Boffi El, Amari E, Kahlert C, Vernazza P, representations of their children’s illness: We plan to study the serum concentration Fehr J, Calmy A, Low N, Martinetti Lucchini • Blood pressure and heart rate rhythmicity in does “rare” make a difference? A qualitative of T in 300 healthy men, > 18 year old, with G, Tarr P. Gonorrhoe: neue Empfehlungen zu obese children. research protocol; b. Phosphate metabolism; 5 different platforms (Abbot®, Beckman Diagnostik und Behandlung. Schweiz Med Forum Lead investigator: GD. Simonetti. c. Interaction between dyselectrolytemias and Coulter®, Roche®, Siemens® and mass 2014;14(20):407–409. QT-interval on standard electrocardiography. spectrometry) to determine if any statistical • Cardiovascular health among Swiss-Italian men difference exists. 3.5 Paediatrics Services invited to the military entry examination. • Early detection and intervention for Swiss-Italian We are recruiting healthy volunteers with (in collaboration with the University Children’s children with autism spectrum disorders. no known history of depression, diabetes, Paediatrics is concerned with the health of infants, Hospital of Bern, the EOC Department of Lead investigator: GP. Ramelli. hypertension or erectile dysfunction. In order children, and adolescents; their growth and Internal Medicine and the Federal Department to avoid any bias due to the circadian rhythm development and their opportunity to achieve full of Defense). Projects currently underway: a. Clinical of T, blood draws are performed between 8-10 potential as adults. Pediatric care encompasses Lead investigator: GD. Simonetti. usefulness of the modified checklist for am and a period of at least 2 weeks from the a broad spectrum of health services ranging autism in toddlers, a validated screening tool; last night shift is required. from preventive health care to the diagnosis • Case reports. b. Outcome following early educational and and treatment of acute and chronic diseases. Lead investigators: GD. Simonetti, MG. behavioral interventions; c. Usefulness of Main funding Paediatrics deals with biological, social and Bianchetti, GP. Ramelli. chromosomal microarray (in collaboration with “Studio marcatori biochimici tiroidei (Study of environmental influences on the developing child A. Ferrarini). thyroid biochemical markers)”: ABREOC; and with the impact of disease and dysfunction Projects currently underway: a. An adolescent on development. Children differ from adults with intermittent claudication; b. Chest • Fever phobia among pediatricians. “Improving the diagnosis of late-onset anatomically, physiologically, immunologically, pain secondary to slipping rib syndrome. Lead investigator: GD. Simonetti, MG. hypogonadism”: Abbot®, Beckman Coulter®, psychologically, developmentally and metabolically. c. Treatment of C3-glomerulopathy with Bianchetti. Roche®, Siemens® are providing the diagnostic Neonatology, the main subspecialty of paediatrics, eculizumab. kits. consists of the medical care of newborn infants, • Metabolism of vitamin D. especially the ill or premature newborn infant. • "Chalk and blackboard interactive workshop” Lead investigators: MG. Bianchetti, GD. Peer reviewed publications in 2014 for pediatricians in training and medical Simonetti, GP. Ramelli. Conza L, Casati Pagani S, Gaia V. Influence of Pediatric Department of Southern Switzerland students: a new kind of medical education. climate and geography on the occurrence of Prof. Giacomo D. Simonetti MD and Prof. (in collaboration with the University Children’s Projects currently underway: a. Quantification Legionella and amoebae in composting facilities. Gian Paolo Ramelli MD are responsible for the Hospital of Milan). of vitamin D metabolites in apparently healthy BMC Res Notes. research unit. Lead investigator: MG. Bianchetti. infants, children and adolescents; b. Regional 2014;7:831. Dr. Pier Luigi Brazzola MD is responsible for differences in the prescription of vitamin D oncologic projects and Dr. Alessandra Ferrarini • Correlation between functional MRI, EEG and among pediatricians in Switzerland.

76 Scientific Report 2014 3. EOC Multisite Departments and Services 77 • Paediatric Oncology Lead local investigator: PL. Brazzola. Hospital of Milan). GM, Cantù M, Bianchetti MG, Ceschi A. Vitamin a. COSS Registry for bone tumours; b. SoTiSar Lead investigator: GD. Simonetti, MG. D status among children and adolescents on 1. Participation in several phase II/III international, Registry: soft tissue tumours, which include Bianchetti. anticonvulsant drugs in southern Switzerland. multicenter studies. sarcomas, gastrointestinal stromal tumours, Swiss Med Wkly. 2014;144:w13996. Lead local investigator: PL. Brazzola. very aggressive juvenile fibromatosis and • Systematic reviews of the literature. hamartomas; c. EuroNet-PHL-C1 Registry for Lead investigators: GD. Simonetti, MG. Scurati-Manzoni E, Fossali EF, Agostoni C, Riva E, Project currently underway: a. SIOPEL 6 Hodgkin lymphoma; d. SIOP-LGG 2004 Registry Bianchetti, GP. Ramelli. Simonetti GD, Zanolari-Calderari M, Bianchetti (International multicenter clinical study uses for Low Grade Glioma; e. HIT 2000 Registry for MG, Lava SAG. Electrolyte abnormalities in cystic chemotherapy combined with surgery for the cerebral tumours; f. EU-RHAB multinational Projects currently underway: a. Breastfeeding fibrosis: systematic review of the literature. Pediatr treatment of standard-risk hepatoblastomas registry for rhabdoid tumours of any anatomical associated hypernatremia; b. Central nervous Nephrol. 2014;29(6):1015-1023. in young children and adolescents); b. AIEOP- site; g. GPOH-MET registry for rare malignant system involvement in rotavirus infections; BFM-ALL 2009 (International multicenter endocrinological tumours; h. STEP Registry for c. Electrolyte abnormalities in cystic fibrosis; Uestuener P, Ferrarini A, Santi M, Mardegan study for the treatment of acute lymphoblastic rare tumours (e.g. carcinoma), i. PI Pathfinder d. Hyponatremia in children with acute C, Bianchetti MG, Simonetti GD, Milani GP, Lava leukemias in young children and adolescents); 5 Study (phase III study of a new recombinant respiratory infections; e. Posterior cerebral SAG. Taste acceptability of pulverized brand- c. HIT-HGG 2007 (International cooperative factor VIII for the prophylaxis and therapy for edema syndrome in children and adolescents; name and generic drugs containing amlodipine or Phase II trial of the HIT-HGG study group for the hemophilia A). f. Skin lesions other than erythema multiforme candesartan. Int J Pharm. 2014;468(1-2):196- treatment of high grade glioma, diffuse intrinsic associated with mycoplasma pneumonia; 198. pontine glioma, and gliomatosis cerebri in • Prevention and management of arterial g. Entrapment of the left renal vein in the children ≥ 3 years and adolescents < 18 hypertension in children and adolescents. fork formed by superior mesenteric artery Paediatric Surgery Service – Regional Hospital years); d. CWS-2007-HR (This study proposes (in collaboration with the University Children’s and abdominal aorta; h. Lobar nephronia in of Bellinzona and Valli standard treatment following the guidelines Hospital of Milan). childhood; i. Evidence-based parenteral fluid Mario Mendoza Sagaon MD of the CWS study group [CWS guidance] for Lead investigator: GD. Simonetti, MG. therapy in childhood; j. acute benign myalgia Head Doctor pediatric soft tissue sarcomas); e. SIOP-CGT- Bianchetti. cruris. II (Prospective Trial for the diagnosis and The Pediatric Surgery Service provides care for treatment of children, adolescents and young Project currently underway: a. Palatability of Main funding children up to 16 years of age who require surgery adults with intracranial Germ Cell Tumours); f. brand-name and generic drugs containing “Meccanismi soggiacenti l'iponatriemia della or are suffering from diseases that frequently need SIOP-PNET-5 (International prospective study antihypertensive agents; b. Salt and blood polmonite del bambino acquisita in comunità surgery. It is a full service, including all the main on clinically standard-risk medulloblastoma pressure among children; c. Pediatric (Mechanisms underlying hyponatremia of surgical specializations, with a preference for mini- in children older than 3 to 5 years with a hypertension screening: a controversy. d. community-acquired pneumonia in children)”: invasive, orthopaedic and often outpatient surgery. low-risk biological profile or an average-risk Ambulatory blood pressure measurement in ABREOC. biological profile); g. Kraniopharyngeom 2007 children Main areas of research (Prospective international multicenter clinical Peer reviewed publications in 2014 (selection) • Retrospective clinical research: Chart review of study to assess the results of using radiotherapy • Schönlein-Henoch purpura and related Dell'Orto VG, Belotti EA, Goeggel-Simonetti our clinical cases/practice. in craniopharyngiomas that have not been vasculitides: a. genetic factors; b. B, Simonetti GD, Ramelli GP, Bianchetti MG, Lead investigator: M. Mendoza. completely removed); h. HR-NBL-1.5 (Open, hepatobiliopancreatic involvement. Lava SAG. Metabolic disturbances and renal multicenter randomized Phase III Trial; therapy Lead investigators: GD. Simonetti, MG. stone promotion on treatment with topiramate: • Pisiform fracture of the wrist in children. optimisation study for high-risk neuroblastoma); Bianchetti, GP. Ramelli. a systematic review. Br J Clin Pharmacol. Lead investigator: V. De Rosa. i. End of Life (To evaluate the possibility to 2014;77(6):958-64. involve young patients in the decision process • Goodpasture’s syndrome in childhood: an Hand fractures in children are frequent but the about the end of life treatment); k. Ewing 2008 inquiry among pediatric nephrologists. Ferrarini A, Lava SAG, Simonetti GD, Ramelli GP, pisiform is a very rare fracture in children, and (International joint protocol aimed ad optimizing Lead investigators: GD. Simonetti. Bianchetti MG; Swiss Italian Society of Paediatrics. the treatment is not clear. We treat fractures management of Ewing sarcoma in subjects Influenzavirus B-associated acute benign myalgia of the pisiform in children conservatively. We eligible for neoadjuvant chemotherapy). • Randomized controlled trial of a single dose of cruris: an outbreak report and review of the literature. studied the literature, and we have given detail oral ibuprofen for croup. Neuromuscul Disord. 2014;24(4):342-346. about the treatment of those fractures in 2. Participation in international registries. (in collaboration with the University Children’s Ramelli V, Ramelli GP, Lava SAG, Siegenthaler children.

78 Scientific Report 2014 3. EOC Multisite Departments and Services 79 Peer reviewed publications in 2014 care patients. However this method has never Main funding Pierluigi Quadri MD Christen S, Mendoza M, Gobet R, Bode P, Weber been studied in a non-critical population. The aim Fondo Scientifico Dermatologia EOC (EOC Head of Service D. Late ureteral obstruction after injection of of this study is to determine the efficacy of vena Dermatology scientific fund), Unità di Melanoma dextranomer/hyaluronic acid copolymer. Urology cava ultrasound guided titrated volume repletion in (Melanoma Unit) (Hospital Clinic de Barcelona. Main areas of research 2014;83(4):920-922. preventing spinal anesthesia-induced hypotension Barcelona, Spain). The following studies are currently underway, the in an elective surgical population. first two of which are in collaboration with the Cravino M, Canavese F, De Rosa V, Marengo L, Peer reviewed publications 2014 Mario Negri Pharmacological Research Institute Samba A, Rousset M, Mansour Khamallah M, 3.7 Dermatology and Allergology/Clinical Hofbauer GF, Anliker M, Boehncke WH, Brand in Milan, Department of Neurosciences, geriatric Andreacchio A. Outcome of displaced distal tibial Immunology Services C, Braun R, Gaide O, Hafner J, Hunger R, Itin neuropsychiatry: metaphyseal fractures in children between 6 P, Kaeuper G, Lautenschlager S, Mainetti C, and 15 years of age treated with elastic stable Dermatology and Allergology/Clinical Streit M. Swiss clinical practice guidelines on • The feasibility of physiotherapy associated with intramedullary nails. Eur J Orthop Surg Traumatol. Immunology Service – Regional Hospital of field cancerization of the skin. Swiss Med Wkly. the cognitive approach (Imagery) for elderly 2014;24(8):1603-1608. Bellinzona and Valli 2014;144:w14026. patients with a fear of falling: observational pilot Carlo Mainetti MD study. Awards 2014 Head Doctor of Dermatology Service Iorizzo M, Marazza G. Measles, mumps, and Lead investigators: F. Meroni, P. Quadri, R. Mario Mendoza Sagaon Giovanni Ferrari MD rubella vaccine: a new option to treat common Pezzati, C. Celeste, L. Curia, F. Gallina, S. Chiari, Honorary Secretary of the European Society of Head of Allergology and Clinical Immunology warts? Int J Dermatol. 2014;53(4):e243-245. S. Ambrogio, E. Biglia, F. Bianchi, D. Zemp, M. Pediatric Endoscopic Society (ESPES) from 1st Service Tettamanti, S. Avesani, N. Schiavone. October 2014 to 1st October 2017. Simon D, Eng PA, Borelli S, Kägi R, Zimmermann Main areas of research C, Zahner C, Drewe J, Hess L, Ferrari G, The purpose of the study is to break the 3.6 Anaesthesiology Services Study on genetic predisposition to malignant Lautenschlager S, Wüthrich B, Schmid- vicious circle brought on by the fear of falling melanoma in Italian Switzerland. Grendelmeier P. Gamma-Linolenic Acid Levels and to improve mobility (and consequently Anaesthesiology Service – Lead investigator: C. Mangas. Correlate with Clinical Efficacy of Evening Primrose the functional capacity of elderly patients), Regional Hospital of Bellinzona and Valli Collaborators: C. Mainetti, D. Castelli (Centro Oil in Patients with Atopic Dermatitis. Adv Ther. considering cognitive interventions (imagery) Luciano Anselmi MD Trasfusionale della Svizzera Italiana- Blood 2014;31(2):180-188. alongside physiotherapy in elderly patients Head Doctor Transfusion Centre of Italian Switzerland). (with or without previous falls without serious Zecca C, Caporro M, Adami M, Mainetti C, Gobbi consequences) who have a fear of falling. Main areas of research Nearly 10% of all cutaneous melanoma (CM) cases C. Fumaric acid esters in psoriasis and multiple The study ended on 31/12/2014: the data Can Vena Cava Ultrasound Guided Volume occur in patients with personal or familial history sclerosis. Clin Exp Dermatol. 2014;39(4):488-91. are being processed. Repletion Prevent Spinal Induced Significant of the disease. From July 2010 to July 2012, 57 Hypotension in Elective Patients? patients (41 families) with familial or personal 3.8 Geriatric Service • Influence of haemodialysis on physical activity Lead investigators: S. Ceruti, L. Anselmi, M. history of multiple CM were included in a study to Pierluigi Quadri MD and motor skills of patients with chronic kidney Peruzzo, D. De Bianchi, S. De Vivo, D. Franceschini, identify germline mutations in high MM-associated Coordinator of the EOC Geriatric Service disease, stage 5 (K/DOQI). A. Saporito. genes (CDKN2A and CDK4) and low/medium Lead investigators: O. Giannini, D. Zemp, C. penetrance variants (MCR1 and MITF) associated The EOC Geriatrics Service, which is present at the Cereghetti, M. Tettamanti, P. Quadri. Spinal anesthesia is a regional anesthesia with CM risk. In that study, a strong founder Regional Hospitals of Lugano, Bellinzona and Valli, technique widely employed in clinical practice. effect in CDKN2A gene and a high incidence of Mendrisio and Locarno, offers a multidisciplinary The purpose of this study is to assess the The common side effects consist in a reduction low/medium penetrance variants in MC1R and approach with specialist day clinics and wards to changes in the degree of autonomy and overall of systemic vascular resistances, with systemic MITF in this population with CM risk could be assess and intervene at an early stage, or prevent mobility that accompany the entry into dialysis hypotension. To avoid this complication, blind identified. Nowadays, the enrollment of healthy these geriatric problems. and to highlight any risk factors associated administration of fluids is commonly used. This controls (without history of CM) is in progress with The Service also operates in a network together with altered strategies of postural control and is accomplished on an empirical basis, carrying the collaboration of “Centro Trasfusionale della with other local dedicated geriatric structures. walking, the fragility of patients and/or dialysis the risk of possible volume overload. Vena cava Svizzera Italiana” (Blood Transfusion Centre of treatment, which are likely to affect the degree ultrasound has been shown to be an effective Italian Switzerland) to compare the genetic results Sottocenerino Geriatric Service – of mobility and autonomy in everyday life, control method to assess fluid responsiveness in critical and better understand them. Regional Hospital of Lugano and Mendrisio of balance and gait, as well as the risk of falling.

80 Scientific Report 2014 3. EOC Multisite Departments and Services 81 • A longitudinal and observational registry of Del Grande F, Subhawong T, Weber K, Aro M, Angiology, Universitäts Herzzentrum Freiburg Primary Objective: to determine whether patients with memory disorders (Ticino Canton Mugera C, Fayad LM. Detection of soft-tissue Bad Krozingen, Bad Krozingen, Germany), D. the administration of bone marrow-derived Study) in the Sottocenerino Geriatrics Service sarcoma recurrence: added value of functional Scheinert (Centre of Vascular Medicine, Heart autologous progenitor cells (VASASTIM) day clinics. MR imaging techniques at 3.0 T. Radiology. Centre Leipzig/Park Hospital, Leipzig, Germany). reduces the incidence of major amputations 2014;271(2):499-511. Participating centres: Bad Krozingen, Leipzig, (defined as being sited through or above the This is a database of patients with balance Bern and Lugano. ankle joint) after 1 year. disorders and gait abnormalities and/or Del Grande F, Santini F, Herzka DA, Aro Secondary Objectives: to determine the with a history of falls assessed anamestically, MR, Dean CW, Gold GE, Carrino JA. Fat- This is a prospective, two-arm randomized incidence of minor amputations (located more functionally and using quantitative tools. suppression techniques for 3-T MR imaging study. The control cohort (PTX PTA group, distally than the ankle joint), changes in the of the musculoskeletal system. Radiographics. Inpact Admiral or Inpact Pacific, Medtronic- number and extent of leg ulcers, resolution of Main funding 2014;34(1):217-233. Invatec) is treated with a PTX-coated PTA rest pain or improvement in pain-free walking ABREOC, Fondo per la Ricerca Geriatrica (Fund balloon. The experimental cohort (Laser + distance, improvement in ankle-brachial index for Geriatric Research) of the Regional Hospital of Bongiovanni M, Vitale VA, Grassi P, Mazzucchelli L. PTX PTA group) is treated with photoablative (ABI) and transcutaneous oxygen pressure Mendrisio. Malignant mixed müllerian tumor with an extensive atherectomy, followed by a PTX-coated PTA (TcPO2). squamous-cell carcinomatous component: a balloon. Subjects matching with the definitions 3.9 Radiology Services potential pitfall in liquid-based cervical cytology. of Rutherford Clinical Categories 1 to 5 with Main funding Acta Cytol. 2014;58(4):413-418. instent lesions located in the superficial femoral “PHOTOPAC study”: funding from Universitäts Radiology Service – Regional Hospital of Lugano artery and the popliteal artery above the knee Herzzentrum Freiburg Bad Krozingen (Bad Filippo Del Grande MD Awards 2014 joint, are eligible for enrollment. Krozingen, Germany). Head Doctor The following poster, presented at the Annual The purpose of this feasibility study is to Meeting of Radiological Society of North America evaluate the safety and effectiveness of “CIRCULATE study”: Cardiocentro Ticino. Main areas of research (RSNA 2014, Chicago, USA, 30th November-5th preparing an instent lesion with photoablative In collaboration with Johns Hopkins Hospital, Bal- December 2014) was awarded a Certificate of atherectomy prior to local Paclitaxel delivery Peer reviewed publications in 2014 (selection) timore, USA: merit: compared to local Paclitaxel delivery without Barbetta I, van den Berg JC. Access and Del Grande F, Fayad LM. “Bone Marrow Signal initial photoablative atherectomy. hemostasis: femoral and popliteal approaches and • SPACE project: technical evaluation with Changes on MRI: What Is Normal?” Primary outcome is Target Lesion Percent closure devices-why, what, when, and how? Semin 3 Tesla MRI of SPACE sequences of the Diameter Stenosis (% DS) at 1 year, defined as Intervent Radiol. 2014;31(4):353-360. peripheral joints. Service of Interventional Radiology – the narrowest point of the target lesion divided Regional Hospital of Lugano by the estimated native vessel diameter at that van den Berg JC. Towards a better understanding • Advanced functional imaging for bone and soft Josua C. van Den Berg MD location, as determined by the ACL. and more efficient treatment of in-stent restenosis. tissue tumours. Head of Service The sponsor ended the study and the data are J Cardiovasc Surg (Torino). 2014;55(3):305-306. being processed. In collaboration with University Hospital Zürich, Most of the interventional activities include vascular van den Berg JC. Strategies for optimizing the Switzerland: interventional radiology (including, for example, • CIRCULATE study: Bone Marrow Derived Cell safety of carotid stenting in the hyperacute period carotid arterial stenting and the positioning of Therapy in Peripheral Arterial Disease (Phase after onset of symptoms. J Cardiovasc Surg • LSOS: Multicentric imaging evaluation of spinal endoprosthesis for abdominal aortic aneurysm). I/II study). (Torino). 2014;55(2 Suppl 1):21-32. canal stenosis. Trial Participants: JC. Van Den Berg, R. Main areas of research Canevascini, R. Rosso, H. Stricker,T. Moccetti, van den Berg JC, Pedrotti M, R. Canevascini, S. • Advanced muscle imaging. D. Sürder. Chimchila Chevili, L. Giovannacci, R. Rosso. In-stent • Participation in the following multicentre study: restenosis: mid-term results of debulking using Peer reviewed publications in 2014 (selection) PHOTOPAC study: Photoablative Atherectomy Trial design: an open-labeled prospective excimer laser and drug-eluting balloons: sustained Del Grande F, Subhawong T, Flammang A, Fayad Followed by a Paclitaxel-Coated Balloon to In- feasibility phase and a second phase in which benefit? J Invasive Cardiol. 2014;26(7):333-337. LM. Chemical shift imaging at 3 Tesla: effect of echo hibit Restenosis in Instent Femoro-popliteal patients will be randomly assigned to an open- von Tengg-Kobligk H, Correa Londono M, von time on assessing bone marrow abnormalities. Obstructions. labeled control group or will be treated with Allmen R, Heverhagen JT, van den Berg JC. Skeletal Radiol. 2014;43(8):1139-1147. Co-lead investigators: T. Zeller (Department of VASASTIM. State of the art imaging to detect endoleaks post-

82 Scientific Report 2014 3. EOC Multisite Departments and Services 83 EVAR with special focus on low-flow endoleaks. J disease 10-year risk score and mild-to- Contrast Ultrasounds and plaque magnetic issues for performing a dynamic assessment Cardiovasc Surg (Torino). 2014;55(5):563-579. moderate atherosclerosis were consecutively resonance (HR-MRI): In vivo comparison in of plaque vascularisation in order to obtain top included in the study. All subjects underwent a human carotid atherosclerosis. images are now undergoing a double check by Radiology Service – dedicated MRI-plaque imaging protocol using Lead investigators: A. Gallino, R. Wyttenbach, the Institution for Atherosclerosis imaging in Regional Hospital of Bellinzona and Valli TOF- and T1w and T2w black-blood-sequences D. Staub of University of Basel and C.Yuan of Seattle. Prof. Rolf Wyttenbach MD with fat suppression (1.5 T). The scan was the Washington University of Seattle (USA). Head Doctor centred on the carotid bulb of the carotid and Main funding the most stenotic lesion of the femoral arteries, This project is a continuation of over 10 “Plaque Neovascularization: assessment by Main areas of research respectively. Plaques were classified according years of research on the progression Contrast Ultrasounds and plaque magnetic • Differences in plaque phenotypes in the carotid to the American Heart Association lesion of atherosclerosis performed at our resonance (HR-MRI): In vivo comparison in and femoral arteries: an in vivo study using MRI type classification and area measurements of Cardiovascular Research Centre and the human carotid atherosclerosis”: Grant SHS plaque imaging. lumen, wall and the major plaque components, Department of Radiology. The study aims at (Schweizerische Herzstiftung) (Duration: 2012- Lead investigators: R. Wyttenbach together such as calcification, necrotic core and evaluating the role of plaque neovascularisation 2014; CHF 158’257). with T. Saam of the University of Grosshadern haemorrhage were determined in consensus in the progression of atherosclerosis at the in Munich (D) by two blinded reviewers using dedicated level of the carotid artery. The investigation Peer reviewed publications 2014 Collaborators: A. Helck of the University of software (MR Plaque View, VP Diagnostics, is a joint project between the Cardiovascular Bordoni A, Cerny A, Bihl F, Alerci M, Mazzola P, Grosshadern in Munich (D) and C. Yuan of the Seattle, USA). Plaque components were Research Centre, the Radiology Division of the Peverelli S, Marini G, Majno P, Mazzucchelli L, Washington University of Seattle (USA). recorded as maximum percentages of the wall Regional Hospital of Bellinzona and Valli, and Spitale A. Survival of hepatocellular carcinoma area. the Vascular Research Laboratory of Prof. C. patients is significantly improving: a population- The aim of the study is to evaluate differences Clinical relevance statement: the ability of in Yuan, Washington University, Seattle, USA. The based study from southern Switzerland. Cancer in plaque composition and morphology within vivo MRI to display plaque composition across project is also performed in cooperation with Epidemiol. 2014;38(6):679-685. the same patient in different vascular beds distinct vascular beds might help improve risk Prof. Daniel Staub, Chief of the Vascular Division using non-invasive MR-plaque imaging. stratification in patients with atherosclerosis. at the University Hospital in Basel. Almost 40 28 patients (67.8± 7.4 years, 8 females) patients were screened as possible candidates with high Framingham general cardiovascular • Plaque Neovascularization: assessment by for this prospective study. Several technical

84 Scientific Report 2014 3. EOC Multisite Departments and Services 85 4 Swiss Clinical Trial Organization 25

20

15

10

5 2014

2013

0 2012

IOSI NSI Surgery SUPSI Cardiology Radiology AnesthesiologyMedical Area DermathologyIntensive Care

Twenty new requests of services were received Clinical Research Day for a total of 39 activities completed or ongoing at The CTU-EOC organized the fourth Clinical Re- the end of 2014; they consisted of statistics (6), search Day, which was held in Bellinzona on March submission of documents to Regulatory Authori- 28th. 4. Swiss Clinical Trial Organization ties (7), preparation of electronic CRF (3), support for nursing activities (4), document writing/review Website (8), drug management (2), monitoring (5), coordi- The new website www.ctueoc.ch was prepared The Swiss Clinical Trial Organization (SCTO) is the 4.1 EOC Clinical Trial Unit (CTU-EOC) nation (1), data entry (3). and implemented with the structure of the CTU- central platform for cooperation in patient-orient- EOC, the list of events, the list of the services pro- ed clinical research in Switzerland. Its primary Collaborators CTU EOC Services 2014 vided, the forms for the request for services. objective is to make Swiss clinical research more In 2014, Prof. Sessa took the role of Administra- The abstracts of the previous clinical research 5% 3% competitive as regards innovation and quality. tive Director corresponding to 40% work time, Drug Coordination days and the program of the courses are also while Mrs. Laura Di Petto started in July a 20% management 18% available on the website. 8% Document The SCTO intends to achieve this goal as follows: work activity as an Administrative Assistant and Data Entry writing/review –– by promoting a culture of studies and high qual- Events Coordinator. Survey

ity of care at a national level; 8% A survey of current or potential CTU-EOC users –– by supporting the creation of a national net- Projects e-CRF was posted in October 2014 on Share Point to work; In 2014, the activity of the EOC Clinical Trial Unit 18% know who the users were, their satisfaction with Regulatory –– by promoting the integration of national clinical (CTU-EOC) increased with 20 new projects start- 11% Affairs the services provided and their unfulfilled requests research in international networks; ed, 13 of which were promoted by collaborators Research and expectations. Nurse –– by building bridges between academia, industry of EOC, 2 by Drug Companies and 5 by Academia.

and the public authorities. Overall, at the end of 2014, 37 projects were on- 13% 16% Study registry going, 15 in the fields of oncology, 17 in neurosci- Monitoring Statistics An electronic registry of all the studies ongoing The SCTO generally promotes favourable condi- ence, 1 in cardiology, 1 in intensive care, 1 in sur- within the EOC was implemented in 2014, where tions in the field of clinical research and coordi- gery, 1 in anesthesiology and 1 in dermatology. information related to study title, principal investi- nates multicenter studies by acting as an interme- Training gator, short study summary, financial support, cur- diary between different studies. Activity increased also in this field, with 11 courses rent status of activities will be collected for all the organized (3 on introduction to GCP, 1 on GCP for studies approved by the Ethics Committee. This The SCTO is a joint initiative of the Swiss National Principal Investigator, 1 on GCP for Sponsor, 2 on electronic archive will be made available within the Science Foundation (SNSF) and the Swiss Acad- biostatistics, 3 on bibliographic research and med- end of 2015 on the website www.eoc.ch and will emy of Medical Sciences (ASSM). ical biobanks, 1 on Pharmacovigilance). provide public information on studies available and A similar program was established for 2015. more generally, on clinical research that is ongoing in the EOC.

88 Scientific Report 2014 4. Swiss Clinical Trial Organization 89 5 Scientific Research Advisory Board (ABREOC) 5. Scientific Research Advisory Board (ABREOC)

The Scientific Research Advisory Board of the ABREOC has the following specific tasks: The Members of ABREOC are the following: • Dimitri Christoforidis MD, PD, Deputy-Head of EOC (ABREOC) was set up in October 2007 as an a. propose general guidelines for the research • Fabrizio Barazzoni MD, MPH, Head Officer of Surgery, Regional Hospital of Lugano; advisory body and to coordinate the research in to be carried out in the hospitals, taking the EOC and Medical Area, Chairman; • Manuela Sarti MD, Oncology Specialist, EOC hospitals. into account local interests, competencies, • Colette Balice, MSc, Specialist Nurse and ABREOC Secretary, EOC Medical Area. ABREOC aims at improving knowledge in the initiatives and activities; Scientific Collaborator of EOC Nursing Area; medical and nursing fields by: b. identify the sectors or new areas in which to • Prof. Enos Bernasconi MD, Deputy-Head of Between 2008 and 2014, 71 of the 117 clinical • favouring research within the EOC; promote or continue research; Internal Medicine, Regional Hospital of Lugano; and translational studies submitted to the EOC’s • promoting collaboration with both national and c. create the necessary general conditions to • Prof. Franco Cavalli MD, Scientific Director of Scientific Research Advisory Board were funded international research institutions; foster research; the IOSI, Bellinzona; by the Scientific Fund. • encouraging the creation of research centres d. provide an assessment of the scientific value • Paola Di Giulio, member of the professional in specific sectors; of research projects for which EOC funding is skills teaching staff (SUPSI) at the Department The projects that received funding are listed in the • creating the right conditions for the greatest requested, paying particular attention to how of Health (DSAN); table attached to the “Report” (Appendices 1, 2, 3, possible integration between research and its the project fits in with the EOC’s vision and • Prof. Augusto Gallino MD, Head of the EOC’s 4, 5 and 6) with the state of progress indicated for clinical applications; mission; Internal Medicine Department, Regional each project: either concluded (with a publication • encouraging interdisciplinary research. e. inform, in line with the available budget, the Hospital of Bellinzona and Valli; or final report) or underway. awarding of funding for research projects not • Piergiorgio Mombelli MD, Consultant in Internal ABREOC operates in accordance with the covered by external funding; Medicine, Regional Hospital of Locarno; The funds allocated by ABREOC since 2008, when current legislation, taking into account the f. assess, when consulted by the EOC head office • Prof. Alain Kaelin MD, Head of Department, the first funding was awarded, are shown below:

recommendations of the Swiss Academy of Medical or local management, the scientific value of NSI, Regional Hospital of Lugano; ABREOC notices of competition 2008 – 2014 Sciences and the Canton Ethics Committee. The studies or scientific research not funded by the • Alberto Pagnamenta MD, Head of Intensive No. projects submitted 117 EOC medical staff may submit research projects EOC and their consistency with the EOC’s vision Care Medicine Service, Regional Hospital of No. projects approved 71 requiring funding to ABREOC to be carried out in and mission; Mendrisio; No. projects rejected 46 the EOC hospitals. g. regularly collect from the Canton’s Ethics Committee • Prof. Gian Paolo Ramelli MD, Head doctor of Total amount requested by all necessary information regarding the research Paediatrics, Regional Hospital of Bellinzona and researchers CHF 8'910,002.40 authorized by and carried out within the EOC. Valli; Amount awarded CHF 3'146,829.20

92 Scientific Report 2014 5. Scientific Research Advisory Board (ABREOC) 93 6 Official Registry of the EOC clinical studies (EOC Database of clinical studies) 6. Official Registry of the EOC clinical studies (EOC Database of clinical studies)

According to the Directive on the establishment of (*A detailed description of the studies carried out in 2014 at Furthermore, the details of the information of the ABREOC, whose purpose is to regulate and promote the EOC following the General Authorization can be found in summary results (record card and attachment(s)) scientific research (clinical and translational) and Appendix 7). for a trial include: taking into account the recommendations of the • trial information; Swiss Academy of Medical Sciences (SAMS) and The data of the trials are entered into the Database • subject disposition; the Cantonal Ethics Committee, it was decided (currently 222 studies) by the researchers • baseline characteristics; to create an Official Register of the EOC clinical themselves, supported by a data manager. • endpoints. studies, which started on 7th April 2014. The CTU-EOC, together with EOC medical Area The Register will become a web-based resource The Database of the EOC clinical studies contains Head Office, supervises the correct conduct of on the website www.eoc.ch by the end of 2015 information on clinical (e.g. interventional, non- the studies, in the specific instance, if the studies and will provide an open-access to information on interventional) and translational trials conducted are carried out according to the "Good Clinical clinical studies on a wide range of diseases and in the EOC hospitals, publicly and privately funded Practice" (GCP), as required by the “Federal Act conditions. (competitive and non-competitive grants) or not on research involving humans” (HRA) (see also supported by sponsors. chapter 4.1, CTU-EOC). The Register is a very important tool to define strategies for further development of clinical The Registry also includes all the EOC studies In the Register, the details in the protocol-related research of the EOC; besides, it will be essential underlying the General Authorization to disclose information include: to support the EOC Master in human medicine professional secrets for research studies carried • the title and the design of the trial; and as required by the selection criteria for the out at EOC institutes (No. 035.0003-43) (www. • the sponsor (if any); recognition of a Cancer Centre (Art. 7 UFG (Federal admin.ch/ch/i/ff/2012/6191.pdf), that • where appropriate, the investigational medi- Law on Financial Aid to Universities): Accreditation were granted by the Berne Panel of Experts on cine (trade name or active substance); and Quality Assurance. Art. 11, 3d UFG: conditions Professional Confidentiality in Medical Research • the research area; - "implement measures to enhance scientific on 7th May 2012 and that will remain valid until • the status (authorised by the Ethical Committee, results and encourage their dissemination"). the expiration in May 2017*. ongoing or interrupted or complete).

96 Scientific Report 2014 6. Official Registry of the EOC clinical studies (EOC Database of clinical studies) 97 7 Publications in 2014 In 2014, the number of peer-reviewed publications numerical values compared to the previous two continued to rise, as compared to the data from years. previous years (+62% of 2011 publications) and Furthermore, our peer-reviewed publications the total impact factor (IF) (expressed as weighted and the total impact factor are comparable with average) seems to have increased, after a slight the publication data of Lucerner Kantonsspital decrease in 2013 (Figure 1). (LUKS) (data taken from News Sonderausgabe Jahresbericht 2013 and 2014) (Figure 3) and As shown in Figure 2, this trend has been probably with those of Cantonal Hospital St. Gallen (KSSG) due to a continuous increase in publications with (data taken from Geschäftsbericht KSSG 2013) an Impact Factor < 5 since 2011. However, it (Figure 4). should also be noted that there was an increase in publications in top-level scientific journals in 2014 (Impact Factor over 10) in terms of absolute

7. Publications in 2014 Figure 1. Publications and total Impact Factor (weighted average) of the EOC in the last 4 years.

The scientific activity carried out by the EOC The Table below shows the number of peer- 300 Services in 2014 resulted in 572 scientific reviewed articles published in 2014 for each 275 publications or communications. Hospital: 250 244 EOC institution Number of More specifically, there were: publications • 275 original articles published in peer-reviewed in 2014 200 194 journals; The Regional Hospital of Lugano 46 170 • 10 books or chapters in books; The Regional Hospital of Bellinzona • 17 original articles published in non-peer- and Valli 33 150 reviewed journals; The Regional Hospital of Mendrisio 5 • 270 communications at national and The Regional Hospital of Locarno 5 100 international conferences. Oncological Institute of Southern Switzerland 136 50 Neurocenter of Southern peer-reviewed publications Switzerland 50 4.9 4.2 3.2 3.4 average IF Total publications 275 0 2011 2012 2013 2014

100 Scientific Report 2014 7. Publications in 2014 101 Figure 2. Absolute numerical values and % of EOC publications sorted according to Impact Factor ranges Figure 3. Comparison between the EOC and the LUKS peer-reviewed publications (2013-2014) with total Impact Factor

300 27 275 2011 4.9 126 (16%) N=170 (74%) 250 244

200 17 200 189 (10%) +14% 150

100

2012 4.2 148 38 N=194 50 (76%) (20%) average IF

3.7 0 3.17 3.36 3.12 publications 8 2013 2013 2014 2014 (4%) EOC LUKS EOC LUKS +26%

Figure 4. Comparison between the EOC and the KSSG peer-reviewed publications in the last 3 years with total Impact Factor 2013 3.2 212 N=244 (87%) 300 27 (11%) 257 250 244 5 227 % 214 (2%) +13 200 194

170 150

2014 3.4 N=275 236 100 (86%) 50 28 average IF (10%) 4.9 4.7 4.2 4.5 3.2 4.6 11 0 publications 2011 2011 2012 2012 2013 2013 (4%) IF < 5 EOC KSSG EOC KSSG EOC KSSG 5 ≤ IF < 10

average IF IF ≥ 10

102 Scientific Report 2014 7. Publications in 2014 103 Publications in peer-reviewed journals in 2014 Benz R, Schanz U, Maggiorini M, Seebach JD, Contact tracing investigation after professional longbeachae pneumonia in a patient with Anaesthesiology Stussi G. exposure to tuberculosis in a Swiss hospital using polymyalgia rheumatica. Risk factors for ICU admission and ICU survival both tuberculin skin test and IGRA. Heart Lung Vessel. 2014;6(2):114-118. Saporito A, Petri GJ, Sturini E, Borgeat A, Aguirre after allogeneic hematopoietic SCT. Bone Marrow Swiss Med Wkly. 2014 Aug 14;144:w13988. IF JA. Transplant. 2014;49(1):62-65. IF 3.466; Ranking 1.877; Ranking 0.678. Internal Medicine Safety and effectiveness of bilateral continuous 0.731. sciatic nerve block for bilateral orthopaedic foot Bonassin TF, Rudiger A, Previsdomini M, Maggiorini Albani M, Balestra B. surgery: a cohort study. Berger MD, Meisel A, Andres M, Schanz U, M. Therapierefraktäre Beinödeme, Hypertonie und Eur J Anaesthesiol. 2014;31(11):620-625. IF Schwarz U, Stussi G. Platelet Consumption an Filter Clotting Using Two Niereninsuffizienz. 3.011; Ranking 0.793. Unusual case of progressive multifocal Different membrane Sizes during Continuous Forum Med Suisse 2014;14(38):706-708. leukoencephalopathy after allogeneic Venovenous Haemodiafiltration in the Intensive Dermatology and Allergology/Clinical Immunology hematopoietic stem-cell transplantation. Care Unit. Anichini A, Balestra B. J Clin Oncol. 2014;32(9):e33-34. IF 17.879; Crit Care Res Pract. 2014;2014:203637. La thalidomide: retour vers le futur. Hofbauer GF, Anliker M, Boehncke WH, Brand Ranking 0.98. doi:10.1155/2014/203637. Forum Med Suisse 2014;14(24):467-469. C, Braun R, Gaide O, Hafner J, Hunger R, Itin P, Kaeuper G, Lautenschlager S, Mainetti C, Streit M. Kirsch M, Götz A, Halter JP, Schanz U, Stussi G, Miguélez M, Merlani P, Gigon F, Verdon M, Annoni Bianchi G, Salvadé V, Lucchini B, Schätti-Stählin S, Swiss clinical practice guidelines on field Dobbels F, De Geest S. JM, Ricou B. Salvadé I, Burnier M, Gabutti L. cancerization of the skin. Differences in health behaviour between recipients Feasibility of a multiple choice Mini Mental State Assessment of subjective and hemodynamic Swiss Med Wkly. 2014;144:w14026. IF 1.877; of allogeneic haematopoietic SCT and the general Examination for chronically critically ill patients. tolerance of different high- and low-flux dialysis Ranking 0.678. population: a matched control study. Crit Care Med. 2014;42(8):1874-1881. IF: membranes in patients undergoing chronic Bone Marrow Transplant. 2014;49(9):1223- 6.147; Ranking 0.923. intermittent hemodialysis: A randomized controlled Iorizzo M, Marazza G. 1230. IF 3.466; Ranking 0.731. trial. Measles, mumps, and rubella vaccine: a new Perren A, Cerutti B, Merlani P, Perren I, Hemodial Int. 2014;18:825-834. IF 1.363; option to treat common warts? Marek A, Stern M, Chalandon Y, Ansari M, Ozsahin Previsdomini M, Massarotto P, Kaufmann M, Ranking 0.315. Int J Dermatol. 2014;53(4):e243-245. IF 1.227; H, Güngör T, Gerber B, Kühne T, Passweg JR, Rothen HU. Ranking 0.322. Gratwohl A, Tichelli A, Seger R, Schanz U, Halter SwissScoring - a nation-wide survey of NEMS Caviezel S, Dratva J, Schaffner E, Schindler C, J, Stussi G; Swiss Blood Stem Cell Transplantation. assessing practices and its accuracy. Acta Zemp Stutz E, de Groot E, Burdet L, Rothe T, Pons Simon D, Eng PA, Borelli S, Kägi R, Zimmermann The impact of T-cell depletion techniques on the Anaesthesiol Scand. 2014;58(4):478-486. IF M, Gaspoz JM, Rochat T, Künzli N, Probst-Hensch C, Zahner C, Drewe J, Hess L, Ferrari G, outcome after haploidentical hematopoietic SCT. 2.31; Ranking 0.621. N, Schmidt-Trucksäss A. Lautenschlager S, Wüthrich B, Schmid- Bone Marrow Transplant. 2014;49(1):55-61. IF Sex-specific associations of cardiovascular risk Grendelmeier P. 3.466; Ranking 0.731. Perren A, Merlani P. factors with carotid stiffness-results from the Gamma-Linolenic Acid Levels Correlate with The difficulty of measuring the measurable. SAPALDIA cohort study. Clinical Efficacy of Evening Primrose Oil in Patients Passweg JR, Pabst T, Blum S, Bargetzi M, Li Q, Respir Care. 2014;59(7):1155-1156. IF 1.84; Atherosclerosis. 2014;235(2):576-84. IF 3.971; with Atopic Dermatitis. Heim D, Stussi G, Gregor M, Leoncini L, Meyer- Ranking 0.321. Ranking 0.785. Adv Ther. 2014;31(2):180-188. IF 2.438; Ranking Monard S, Brauchli P, Chalandon Y; Swiss Group 0.54. for Clinical Cancer Research (SAKK). Previsdomini M, Cerutti B, Merlani P, Kaufmann M, Dell’Orto V, Bernasconi E, Pezzoli V, Queirolo S, Azacytidine for acute myeloid leukemia in elderly or van Gessen E, Rothen HU, Perren A. Ramelli GP. Zecca C, Caporro M, Adami M, Mainetti C, Gobbi C. frail patients: a phase II trial (SAKK 30/07). SwissScoring - a nation-wide survey of SAPS II Severe, life-threatening epstein-barr virus Fumaric acid esters in psoriasis and multiple Leuk Lymphoma. 2014;55(1):87-91. IF 2.605; assessing practices and its accuracy. encephalitis in an immunocompetent adolescent sclerosis. Ranking 0.574. Swiss Med Wkly. 2014;144:w14090. IF 1.877; girl. Clin Exp Dermatol. 2014;39(4):488-91. IF 1.234; Ranking 0.678. J Pediatr Neurol. 2014;12: 217-219. Ranking 0.339. Intensive Care Medicine Reynaldos Canton Migotto T, Gyorik Lora S, Gaia V, Drescher SM, von Wyl V, Yang WL, Böni J, Haematology Balmelli C, Zysset F, Pagnamenta A, Francioli P, Pagnamenta A. Yerly S, Shah C, Aubert V, Klimkait T, Taffé P, Lazor-Blanche C, Zanetti G, Zellweger JP. ARDS with septic shock due to Legionella Furrer H, Battegay M, Ambrosioni J, Cavassini

104 Scientific Report 2014 7. Publications in 2014 105 M, Bernasconi E, Vernazza P, Ledergerber B, Flammer Syndrome. Costs and yield of a 15-month preparticipation Cavassini M, Abrosioni J, Bernasconi E, Furrer H, Günthard H, Kouyos RD and the Swiss HIV Cohort EPMA J. 2014;5(1):11. cardiovascular examination with ECG in 1070 Rauch A, the Swiss HIV Cohort Study. Study. Treatment-naïve individual are the major young athletes in Switzerland: implications for Changes in biomarkers of liver disease during source of transmitted HIV-1 drug resistance in me Kouyos RD, Rauch A, Böni J, Yerly S, Shah C, routine ECG screening. successful combination antiretroviral therapy in who have sex with men in the Swiss HIV Cohort Aubert V, Klimkait T, Kovari H, Calmy A, Cavassini Br J Sports Med. 2014;48(15):1157-61. IF HIV-HCV-coinfected individuals. Study. M, Battegay M, Vernazza PL, Bernasconi E, 4.171; Ranking 0.938. Antivir Ther. 2014;19(2):149-159. IF 3.143; Clin Infect Dis. 2014;58(2):285-294. IF 9.416; Ledergerber B, Günthard HF; the Swiss HIV Cohort Ranking 0.738. Ranking 0.986. Study. Metzner KJ, Scherrer AU, von Wyl V, Böni J, Clustering of HCV coinfections on HIV phylogeny Yerly S, Klimkait T, Aubert V, Furrer H, Hirsch HH, Wang Q, Young J, Bernasconi E, Vernazza P, Gallino A, Aboyans V, Diehm C, Cosentino F, indicates domestic and sexual transmission of Vernazza PL, Cavassini M, Calmy A, Bernasconi E, Calmy A, Cavassini M, Furrer H, Fehr J, Bucher HC, Stricker H, Falk E, Schouten O, Lekakis J, Amann- HCV. Weber R, Günthard HF. Swiss HIV Cohort Study. Battegay M and the Swiss HIV Cohort Study. Vesti B, Siclari F, Poredos P, Novo N, Brodmann M, Int J Epidemiol. 2014;43(3):887-96. IF 9.197; Limited clinical benefit of minority K103N and Virologic and immunologic responses in treatment- Schulte KL, Vlachopoulos C, De Caterina R, Libby Ranking 1. Y181C-variant detection in addition to routine naïve patients to ritonavir-boosted atazanavir of P, Baumgartner I. European Society of Cardiology genotypic resistance testing in antiretroviral efavirenz with a common backbone. Working Group on Peripheral Circulation. Kouyos RD, Rauch A, Braun DL, Yang WL, Böni therapy-naïve patients. HIV Clin Trials. 2014;15(3):92-103. IF 2.141; Non-Coronary Atherosclerosis. J, Yerly S, Klimkait T, Aubert V, Shah C, Kovari H, AIDS 2014;28(15):2231-2239. IF 6.557; Ranking Ranking 0.452. Eur Heart J. 2014;35(17):1112-1119. IF 14.723; Calmy A, Cavassini M, Vernazza PL, Bernasconi E, 0.957. Ranking 0.984. Ledergerber B, Günthard HF, and the Swiss HIV Young J, Wang Q, Fux CA, Bernasconi E, Furrer Cohort Study (SHCS). Ogna A, Forni Ogna V, Bochud M, Paccaud F, H, Vernazza P, Calmy A, Cavassini M, Weber R, Guggiari U, Balestra B. Higher risk of incident hepatitis C virus coinfection Gabutti L, Burnier M; Swiss Survey on Salt Group. Battegay M, Bucher HC. Swiss HIV Cohort Study. Das Reynolds-Syndrom. among men who have sex with men, in whom the Prevalence of obesity and overweight and The rate of recovery in renal function when Forum Med Suisse 2014;14(8):156-157. HIV genetic bottleneck at transmission was wide. associated nutritional factors in a population- patients with HIV infection discontinue treatment J Infect Dis. 2014;210(10):1555-1561. IF 5.778; based Swiss sample: an opportunity to analyze the with tenofovir. Guessous I, McClellan W, Kleinbaum D, Vaccarino Ranking 0.942. impact of three different European cultural roots. HIV Med. 2014;15(8):505-510. IF 3.454; Ranking V, Zoller O, Theler JM, Paccaud F, Burnier M, Eur J Nutr. 2014;53(5):1281-1290. IF 3.84; 0.725. Bochud M. Swiss Survey on Salt Group. Kutz A, Grolimund E, Christ-Crain M, Thomann Ranking 0.795. Comparisons of Serum Vitamin D Levels, Status, R, Falconnier C, Hoess C, Henzen C, Zimmerli Interventional Radiology and Determinants in Populations With and Without W, Mueller B, Schuetz P; ProHOSP Study Group Pastori MM*, Sarti M*, Pons M, Barazzoni F. Chronic Kidney Disease Not Requiring Renal (Azzola A). Assessing the impact of bibliographical support on Barbetta I, van den Berg JC. Dialysis: A 24-Hour Urine Collection Population- Pre-analytic factors and initial biomarker levels in the quality of medical care in patients admitted to Access and hemostasis: femoral and popliteal Based Study. community-acquired pneumonia patients. an internal medicine service: a prospective clinical, approaches and closure devices-why, what, when, J Ren Nutr. 2014;24(5):303-312. IF 2.548; BMC Anesthesiol. 2014;14:102. IF 1.333; open, randomised two-arm parallel study. and how? Ranking 0.712. Ranking 0.276. Evid Based Med. 2014;19(5):163-168. Semin Intervent Radiol. 2014;31(4):353-360. (*MMP and MS contributed equally) Kern L, Condrau S, Baty F, Wiegand J, van Gestel Manconi M, Zavalko I, Bassetti CL, Colamartino E, Giacchi M, van den Berg JC, Pedrazzini GB. AJ, Azzola A, Tamm M, Brutsche M. Pons M, Ferri R. Regoes R, McLaren P, Battegay M, Bernasconi Current access and closure options for TAVR Oxygen kinetics during 6-minute walk tests in Respiratory-related leg movements and their E, Calmy A, Günthard H, Hoffmann M, Rauch A, patients. patients with cardiovascular and pulmonary relationship with periodic leg movements during Telenti A, Fellay J and the Swiss HIV Cohort Study. EVToday 2014;13(2):69-71. disease. sleep. Disentangling human tolerance and resistance BMC Pulm Med. 2014;14:167. IF 2.489; Sleep. 2014;37(3):497-504. IF 5.062; Ranking against HIV. van den Berg JC. Ranking 0.491. 0.901. PLoS Biol. 2014;12(9):e1001951. IF 11.771; Atherectomy and DCB in the SFA: a summary of Ranking 1. the data. Konieczka K, Ritch R, Traverso CE, Kim DM, Kook Menafoglio A, Di Valentino M, Segatto JM, Siragusa EVToday 2014 ;13(8):28-32. MS, Gallino A, Golubnitschaja O, Erb C, Reitsamer P, Pezzolli R, Maggi M, Romano GA, Moschowitis Rohrbach J, Stickel F, Schmid P, Thormann W, HA, Kida T, Kurysheva N, Yao K. G, Wilhelm M, Gallino A. Kovari H, Scherrer A, Günthard HF, Vuichard D, van den Berg JC.

106 Scientific Report 2014 7. Publications in 2014 107 Laser debulking and DEB for in-stent restenosis: on anticonvulsant drugs in southern Switzerland. The refinement of genetic predictors of multiple R, Preziosa P, Colombo B, Rodegher M, Falini A, technique and review of the literature. Swiss Med Wkly. 2014;144:w13996. IF 1.877; sclerosis. Comi G, Filippi M. J Cardiovasc Surg (Torino). 2014;55(3):351-357. Ranking 0.678. PLoS One. 2014;9(5):e96578. IF: 3.534; Ranking Influence of the topography of brain damage on IF 1.365; Ranking 0.487. 0.873. depression and fatigue in patients with multiple Reynaldos Canton Migotto T, Györik Lora S, Gaia V, sclerosis. van den Berg JC. Pagnamenta A. Disanto G, Kjetil Sandve G, Ricigliano VA, Pakpoor Mult Scler. 2014;20(2):192-201. IF 4.863; Strategies for optimizing the safety of carotid ARDS with septic shock due to Legionella J, Berlanga-Taylor AJ, Handel AE, Kuhle J, Holden Ranking 0.885. stenting in the hyperacute period after onset of longbeachae pneumonia in a patient with L, Watson CT, Giovannoni G, Handunnetthi L, symptoms. polymyalgia rheumatica. Ramagopalan SV. Hamilton A, Newby PR, Carr-Smith JD, Disanto G, J Cardiovasc Surg (Torino). 2014;55(2 Suppl Heart Lung Vessel. 2014;6(2):114-118. DNase hypersensitive sites and association with Allahabadia A, Armitage M, Brix TH, Chatterjee 1):21-32. IF 1.365; Ranking 0.487. multiple sclerosis. K, Connell JM, Hegedüs L, Hunt PJ, Lazarus JH, Trellu LT, Oertle D, Itin P, Furrer H, Scheidegger Hum Mol Genet. 2014;23(4):942-948. IF 6.677; Pearce SH, Robinson BG, Taylor JC, Vaidya B, Wass van den Berg JC. C, Stoeckle M, Schmid P, Bernasconi E, Cavassini Ranking 0.907. JA, Wiersinga WM, Weetman AP, Ramagopalan Towards a better understanding and more efficient M, Boffi El, Amari E, Kahlert C, Vernazza P, Fehr J, SV, Franklyn JA, Gough SC, Simmonds MJ. treatment of in-stent restenosis. Calmy A, Low N, Martinetti Lucchini G, Tarr P. Elangovan RI, Disanto G, Berlanga-Taylor AJ, Impact of month of birth on the development of J Cardiovasc Surg (Torino). 2014;55(3):305-306. Gonorrhoe: neue Empfehlungen zu Diagnostik und Ramagopalan SV, Handunnetthi L. autoimmune thyroid disease in the United Kingdom IF 1.365; Ranking 0.487. Behandlung. Regulatory genomic regions active in immune cell and Europe. Schweiz Med Forum 2014;14(20):407–409. types explain a large proportion of the genetic risk J Clin Endocrinol Metab. 2014;99(8):E1459-65. von Tengg-Kobligk H, Correa Londono M, von of multiple sclerosis. IF 6.31; Ranking 0.901. Allmen R, Heverhagen JT, van den Berg JC. Neurology J Hum Genet. 2014;59(4):211-215. IF 2.526; State of the art imaging to detect endoleaks post- Ranking 0.469. Maestri M, Fulda S, Ferini-Strambi L, Zucconi M, EVAR with special focus on low-flow endoleaks. Bersano A, Melchiorre P, Moschowitis G, Tavarini Marelli S, Staedler C, Bassetti CL, Manconi M. J Cardiovasc Surg (Torino). 2014;55(5):563-579. F, Cereda C, Micieli G, Parati E, Bassetti C. Ferri R, Cosentino FI, Manconi M, Rundo F, Bruni Polysomnographic record and successful IF 1.365; Ranking 0.487. Tako-tsubo syndrome as a consequence and O, Zucconi M. management of augmentation in restless legs cause of stroke. Increased electroencephalographic high syndrome/Willis-Ekbom disease. van den Berg JC, Pedrotti M, Canevascini R, Funct Neurol. 2014;29(2):135-137. IF 1.86; frequencies during the sleep onset period in Sleep Med. 2014;15(5):570-575. IF 3.1; Ranking Chimchila Chevili S, Giovannacci L, Rosso R. Ranking 0.259. patients with restless legs syndrome. 0.717. In-stent restenosis: mid-term results of debulking Sleep. 2014;37(8):1375-1381. IF 5.062; Ranking using excimer laser and drug-eluting balloons: Caporro M, Disanto G, Gobbi C, Zecca C. 0.901. Maino P, Koetsier E, Perez RS. sustained benefit? Two decades of subcutaneous glatiramer acetate Fentanyl Overdose Caused by Malfunction of J Invasive Cardiol. 2014;26(7):333-337. IF 0.824; injection: current role of the standard dose, and Galati S, Möller JC, Städler C. SynchroMed II Intrathecal Pump: Two Case Ranking 0.139. new high-dose low-frequency glatiramer acetate in Ropinirole-induced Pisa syndrome in Parkinson Reports. relapsing-remitting multiple sclerosis treatment. disease. Reg Anesth Pain Med. 2014;39(5):434-437. IF Laboratory Medicine Patient Prefer Adherence. 2014;8:1123-1134. IF Clin Neuropharmacol. 2014;37(2):58-59. IF 2.12; Ranking 0.517. 1.491; Ranking 0.53. 1.836; Ranking 0.408. Conza L, Casati Pagani S, Gaia V. Manconi M, Ott S, Bassetti C. Influence of climate and geography on the Di Trani M, Di Roma F, Andriola E, Leone D, Parisi Gobbi C, Rocca MA, Pagani E, Riccitelli GC, Pravatà Integrating the review of Gottlieb et al. with the occurrence of Legionella and amoebae in P, Miano S, Donfrancesco R. Comorbid Depressive E, Radaelli M, Martinelli-Boneschi F, Falini A, Copetti SAS-CARE Study. composting facilities. Disorders in ADHD: The Role of ADHD Severity, M, Comi G, Filippi M. Sleep. 2014;37(3):623-624. IF 5.062; Ranking BMC Res Notes. 2014;7:831. Subtypes and Familial Psychiatric Disorders. Forceps minor damage and co-occurrence of 0.901. Psychiatry Investig. 2014;11(2):137-142. IF depression and fatigue in multiple sclerosis. Ramelli V, Ramelli GP, Lava SA, Siegenthaler GM, 1.149; Ranking 0.332. Mult Scler. 2014;20(12):1633-1640. IF 4.863; Manconi M, Zavalko I, Bassetti CL, Colamartino E, Cantù M, Bianchetti MG, Ranking 0.885. Pons M, Ferri R. Ceschi A. Disanto G, Dobson R, Pakpoor J, Elangovan RI, Respiratory-related leg movements and their Vitamin D status among children and adolescents Adiutori R, Kuhle J, Giovannoni G. Gobbi C, Rocca MA, Riccitelli G, Pagani E, Messina relationship with periodic leg movements during sleep.

108 Scientific Report 2014 7. Publications in 2014 109 Sleep. 2014;37(3):497-504. IF 5.062; Ranking 0.901. Pakpoor J, Handel AE, Disanto G, Davenport RJ, Front Behav Neurosci 2014; 8:331. IF 4.16; V, Tubaro, A, Gobbi C. Giovannoni G, Ramagopalan SV; Association of Ranking 0.857. Motor and sensory responses after percutaneous Manconi M, Zavalko I, Cereda C, Pisarenco I, Ott S, British Neurologists. tibial nerve stimulation (PTNS) in multiple sclerosis Fulda S, Bassetti CL. National survey of UK medical students on the Villa MP, Castaldo R, Miano S, Paolino MC, Vitelli patients with lower urinary tract symptoms treated Longitudinal polysomnographic assessment from perception of neurology. O, Tabarrini A, Mazzotta AR, Cecili M, Barreto M. in daily practice. acute to subacute phase in infratentorial versus BMC Med Educ. 2014;14:225. IF: 1.409; Ranking Adenotonsillectomy and orthodontic therapy in Eur J Neurol. 2014;21(3):506-511. IF: 3.852; supratentorial stroke. 0.845. pediatric obstructive sleep apnea. Sleep Breath. Ranking 0.817. Cerebrovasc Dis. 2014;37(2):85-93. IF 3.698; 2014;18(3):533-539. IF 2.9; Ranking 0.67. Ranking 0.791. Palagini L, Gemignani A, Banti S, Manconi M, Mauri Zecca C, Digesu GA, Robshaw P, Singh A, ElNeil S, M, Riemann D. Vinai P, Cardetti S, Studt S, Carpegna G, Ferrato N, Gobbi C. Mariano MO, Esteves AM, Frank MK, Caperuto LC, Chronic sleep loss during pregnancy as a Vallauri P, Casey H, Vinai L, Vinai P, Ferini Strambi Maintenance percutaneous posterior nerve Manconi M, Tufik S, De Mello MT. determinant of stress: impact on pregnancy L, Speciale M, Manconi M. stimulation for refractory lower urinary tract Changes in motor behavior during pregnancy outcome. Clinical validity of the descriptor. "Presence of a symptoms in patients with multiple sclerosis. in rats: the basis for a possible animal model of Sleep Med. 2014 Aug;15(8):853-859. IF 3.1; belief that one must eat in order to get to sleep" in J Urol. 2014;191(3):697-702. IF: 3.753; Ranking restless legs syndrome. Ranking 0.717. diagnosing the Night Eating Syndrome. 0.89. Rev Bras Ginecol Obstet. 2014;36(10):436-441. Appetite. 2014;75:46-48. IF 2.52; Ranking 0.538. Pignatti R, Bertella L, Scarpina F, Mauro A, Zecca C, Riccitelli GC, Calabrese P, Pravatà E, Miano S, Peraita-Adrados R. Portolani E, Calabrese P. Vitelli O, Miano S, Tabarrini A, Mazzotta AR, Supino Candrian U, Guttmann CRG, Gobbi C. Pediatric insomnia: clinical, diagnosis, and Italian version of the Parkinson Neuropsychomet- MC, Forlani M, Villa MP. Treatment satisfaction, adherence and treatment. ric Dementia Assessment (PANDA): a useful in- Epilepsy and sleep-disordered breathing as false behavioural assessment in patients de-escalating Rev Neurol. 2014;58(1):35-42. IF 0.93. strument to detect cognitive impairments in Par- friends: a case report. from natalizumab to interferon beta. kinson's Disease. J Child Neurol. 2014;29(10):NP114-7. IF 1.7; BMC Neurol. 2014;14:38-45. IF 2.486; Ranking Mordasini L, Kessler TM, Kiss B, Schüpbach M, J Parkinsons Dis. 2014; 4(2):151-160. IF 1.097; Ranking 0.563. 0.571. Pollo C, Kaelin-Lang A. Ranking 0.116. Bladder function in patients with dystonia Wesström J, Skalkidou A, Manconi M, Fulda S, Neuroradiology undergoing deep brain stimulation. Parkinsonism Pollo C, Kaelin-Lang A, Oertel MF, Stieglitz L, Taub Sundström-Poromaa I. Relat Disord 2014; 20(9):1015-1017. IF 4.126; E, Fuhr P, Lozano AM, Raabe A, Schüpbach M. Pre-pregnancy restless legs syndrome (Willis- Bonaldi G, Brembilla C, Foresti C, Cianfoni A. Ranking 0.843. Directional deep brain stimulation: an intraopera- Ekbom Disease) is associated with perinatal Transarticular laser discal fragmentectomy. A tive double-blind pilot study. depression. new minimally invasive surgical approach for Paganetti P, Antoniello K, Devraj K, Toni N, Kieran Brain. 2014; 137(7): 2015-2026. IF 10.226; J Clin Sleep Med. 2014 May 15;10(5):527-33. IF challenging disc herniations in the elderly. D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Ranking 0.979. 2.826; Ranking 0.654. Interv Neuroradiol. 2014;20(5): 555-563. IF 0.73; Schrattenholz A, Liebner S, Havas D, Windisch M, Ranking 0.115. Cirrito JR, Pfeifer A, Muhs A. Ramien C, Pachnio A, Sisay S, Begum J, Leese Zecca C, Caporro M, Adami M, Mainetti C, Gobbi C. Increased efflux of amyloid-β peptides through the A, Disanto G, Kuhle J, Giovannoni G, Rickinson A, Fumaric acid esters in psoriasis and multiple Boulter DJ, Rumboldt Z, Bonaldi G, Muto M, blood-brain barrier by muscarinic acetylcholine Ramagopalan SV, Moss P, Meier UC. sclerosis. Cianfoni A. receptor inhibition reduces pathological Hypovitaminosis-D and EBV: no interdependence Clin Exp Dermatol. 2014;39(4):488-491. IF Tilting the gantry for CT-guided spine procedures. phenotypes in mouse models of brain amyloidosis. between two MS risk factors in a healthy young UK 1.234; Ranking 0.339. Radiol Med. 2014;119(10):750-757. IF 1.368; J Alzheimers Dis. 2014; 38(4):767-786. IF 3.612; autumn cohort. Ranking 0.358. Ranking 0.657. Mult Scler. 2014 May;20(6):751-3. IF 4.863; Zecca C, Caporro M, Györik S, Gobbi C. Ranking 0.885. Life threatening asthma attack during prolonged Caulo M, Panara V, Tortora D, Mattei PA, Briganti Pakpoor J, Goldacre R, Disanto G, Giovannoni G, fingolimod treatment: Case report. C, Pravatà E, Salice S, Cotroneo AR, Tartaro A. Goldacre MJ. Sgroi S, Kaelin-Lang A, Capper-Loup C. Patient Prefer Adherence. 2014;8:987-989. Data-driven grading of brain gliomas: a Alcohol misuse disorders and multiple sclerosis Spontaneous locomotor activity and L-DOPA- IF.1.491; Ranking 0.53. multiparametric MR imaging study. Radiology. risk. induced dyskinesia are not linked in 6-OHDA 2014. 272(2):494-503. IF 6.214; Ranking 0.975. JAMA Neurol. 2014 Sep;71(9):1188-1189. IF 7.01. parkinsonian rats. Zecca C, Digesu GA, Robshaw P, Puccini F, Kullar

110 Scientific Report 2014 7. Publications in 2014 111 Cianfoni A, Massari F, Dani G, Lena JR, Rumboldt and clinical variants. Society of Ophthalmology Lombardia (SOL). selective internal radiation therapy with yttrium-90: Z, Vandergrift WA, Bonaldi G. Brain Lang. 2014;135:57-65. IF 3.309; Ranking 1. Perioperative management of antiplatelet therapy a first evidence-based review. Percutaneous ethanol embolization and in patients with coronary stents undergoing ScientificWorldJournal. 2014;2014:879469. IF cement augmentation of aggressive vertebral Neurosurgery cardiac and non-cardiac surgery: a consensus 1.219; Ranking 0.727 hemangiomas at two adjacent vertebral levels. document from Italian cardiological, surgical and J Neuroradiol. 2014;41(4):269-274. IF 1.132; Robert T, Duc C, San Millan Ruiz D, Morard M. anaesthesiological societies. Assadi M, Yarani M, Zakavi SR, Jangjoo A, Memar Ranking 0.258. Solitary fibrous tumour with intramedullary EuroIntervention. 2014 May;10(1):38-46. IF B, Treglia G, Aliakbarian M, Mehrabibahar M, component: case report and review of the 3.758; Ranking 0.738. Sadeghi R. Cianfoni A, Massari F, Ewing S, Persenaire M, Literature. Sentinel node mapping in papillary thyroid Rumboldt Z, Bonaldi G. Neurol Neurochir Pol. 2014;48(2):144-149. IF Wu Y, Lucia K, Lange M, Kuhlen D, Stalla GK, carcinoma using combined radiotracer and blue Combining percutaneous pedicular and 0.537 Ranking; 0.084. Renner U. dye methods. extrapedicular access for tumor ablation in a Hypoxia inducible factor-1 is involved in growth Endokrynol Pol. 2014;65(4):281-286. IF 1.208; thoracic vertebral body. Robert T, Martinez-Manas R, San Millan Ruiz D, factor, glucocorticoid and hypoxia mediated Ranking 0.132. Interv Neuroradiol. 2014; 20(5): 603-608. IF Morard M. regulation of vascular endothelial growth 0.73; Ranking 0.115. Cervical Intramedullary Metastasis from Cerebral factor-A in human meningiomas. J Neurooncol. Bertagna F, Bertoli M, Bosio G, Biasiotto G, Sadeghi Glioblastoma Multiforme. 2014;119(2):263-273. IF 2.787; Ranking 0.634. R, Giubbini R, Treglia G. Di Lazzaro V, Giambattistelli F, Pravatà E, Assenza Clin Neurol Neurosurg. 2014;123:61-63. IF Diagnostic role of radiolabelled choline PET or G. 1.248; Ranking 0.426. Nursing Medicine PET/CT in hepatocellular carcinoma: a systematic Brachial palsy after deep sleep. review and meta-analysis. J Neurol Neurosurg Psychiatry 2014; Rossini R, Musumeci G, Visconti LO, Bramucci Pedrazzani C, Bianchi M, Valcarenghi D, Dimonte Hepatol Int 2014;8(4):493-500. IF 2.468; Ranking 85(12):1409-1410. IF 5.58; Ranking 0.985. E, Castiglioni B, De Servi S, Lettieri C, Lettino M, V. 0.541. Piccaluga E, Savonitto S, Trabattoni D, Capodanno The implementation of recommendations in daily Distefano D, Cianfoni A. D, Buffoli F, Parolari A, Dionigi G, Boni L, Biglioli F, practice: the experience of the nurses of the Bertagna F, Bertoli M, Treglia G, Manenti S, Imaging of spinal cord compression. Valdatta L, Droghetti A, Bozzani A, Setacci C, Ravelli Oncology Institute of Southern Switzerland. Salemme M, Giubbini R. Imaging in Medicine 2014;6(1): 86-116. P, Crescini C, Staurenghi G, Scarone P, Francetti Assist Inferm Ric. 2014;33(4):189-197. IF 0.4. Incidental 11C-choline PET/CT uptake due to L, D'Angelo F, Gadda F, Comel A, Salvi L, Lorini L, esophageal carcinoma in a patient studied for Pravatà E, Cereda C, Gabutti A, Distefano D, Antonelli M, Bovenzi F, Cremonesi A, Angiolillo DJ, Nuclear Medicine prostate cancer. Cianfoni A. Guagliumi G; Italian Society of Invasive Cardiology Clin Nucl Med. 2014;39(10):e442-4. IF 2.857; Late-onset cauda equina contrast enhancement: (SICI-GISE); Italian Association of Hospital Annunziata S, Caldarella C, Pizzuto DA, Galiandro F, Ranking 0.775. a rare magnetic resonance imaging finding in Cardiologists (ANMCO); Italian Society for Cardiac Sadeghi R, Giovanella L, Treglia G. subacute spinal cord infarction. Surgery (SICCH); Italian Society of Vascular and Diagnostic accuracy of fluorine-18-fluorodeoxyglu- Bertagna F, Giubbini R, Treglia G. Spine J. 2014;14(12):3065-3066. IF 2.8; Ranking Endovascular Surgery (SICVE); Italian Association cose positron emission tomography in the evalua- Positron emission tomography/computed 0.846. of Hospital Surgeons (ACOI); Italian Society of tion of the primary tumor in patients with cholan- tomography for diagnosis of prosthetic valve Surgery (SIC); Italian Society of Anaesthesia and giocarcinoma: a meta-analysis. endocarditis: suggestions to increase diagnostic Pravatà E, Sestieri C, Colicchio G, Colosimo C, Intensive Care Medicine (SIAARTI); Lombard Biomed Res Int. 2014;2014:247693. IF 2.706. accuracy. Romani GL, Caulo M. Society of Surgery (SLC); Italian Society of J Am Coll Cardiol. 2014;63(4):378-379. IF Functional connectivity MRI and post-operative Maxillofacial Surgery (SICMF); Italian Society of Annunziata S, Caldarella C, Treglia G. 15.343; Ranking 1. language performance in temporal lobe epilepsy: Reconstructive Plastic Surgery and Aesthetics Cost-effectiveness of Fluorine-18-Fluorodeoxyglu- initial experience. (SICPRE); Italian Society of Thoracic Surgeons cose positron emission tomography in tumours Bertagna F, Orlando E, Bertoli M, Treglia G. Neuroradiol J. 2014;27(2):158-62. IF 1.132; (SICT); Italian Society of Urology (SIU); Italian Society other than lung cancer: A systematic review. Incidental F18-FDG Breast Uptake: How to Ranking 0.258. of Orthopaedics and Traumatology (SIOT); Italian World J Radiol. 2014;6(3):48-55. Consider and Manage. Society of Periodontology (SIdP); Italian Federation Arch Breast Cancer. 2014;1(1):3-4. Silveri MC, Pravatà E, Brita AC, Improta E, Ciccarelli of Scientific Societies of Digestive System Diseases Annunziata S, Treglia G, Caldarella C, Galiandro F. N, Rossi P, Colosimo C. Lombardia (FISMAD); Association of Obstetricians The role of 18F-FDG-PET and PET/CT in patients Bertagna F, Treglia G, Orlando E, Dognini L, Primary progressive aphasia: Linguistic patterns Gynaecologists Italian Hospital Lombardia (AOGOI); with colorectal liver metastases undergoing Giovanella L, Sadeghi R, Giubbini R.

112 Scientific Report 2014 7. Publications in 2014 113 Prevalence and clinical significance of incidental Caldarella C, Muoio B, Isgrò MA, Porfiri E, Treglia Feldt-Rasmussen U, Verburg FA, Luster M, Cupini with negative anatomical imaging and radioiodine F18-FDG breast uptake: a systematic review and G, Giovanella L. C, Chiovato L, Duntas L, Elisei R, Rimmele H, scan? meta-analysis. The role of fluorine-18-fluorodeoxyglucose positron Seregni E, Smit JW, Theimer C, Giovanella L. Nuklearmedizin. 2014;53(1):1-10. IF 1.671; Jpn J Radiol. 2014;32(2):59-68. IF 0.721; Ranking emission tomography in evaluating the response Thyroglobulin autoantibodies as surrogate Ranking 0.492. 0.108. to tyrosine-kinase inhibitors in patients with biomarkers in the management of patients with metastatic primary renal cell carcinoma. differentiated thyroid carcinoma. Giovanella L, Treglia G, Ceriani L, Weidner S, Bertagna F, Treglia G, Rossini P, Giubbini R. Radiol Oncol. 2014;48(3):219-227. Curr Med Chem. 2014;21(32):3687-3692. IF Perriard U, Bongiovanni M. An unusual orbital localization of wegener IF 1.667; Ranking 0.236. 3.715; Ranking 0.862. Left atrial metastasis of Hürthle-cell thyroid granulomatosis detected by 18F-FDG PET/CT. carcinoma mimicking myxoma. Clin Nucl Med. 2014;39(8):711-712. IF 2.857; Caldarella C, Treglia G, Giordano A. Giovanella L, Ceriani L, Treglia G. J Nucl Cardiol. 2014;21(2):406-407. IF 2.645; Ranking 0.775. Diagnostic performance of dedicated positron Role of isotope scan, including positron emission Ranking 0.717. emission mammography using fluorine-18- tomography/computed tomography, in nodular Bongiovanni M, Mazzucchelli L, Giovanella L, fluorodeoxyglucose in women with suspicious goitre. Giovanella L, Treglia G, Sadeghi R, Trimboli P, Frattini M, Pusztaszeri M. breast lesions: a meta-analysis. Best Pract Res Clin Endocrinol Metab. Ceriani L, Verburg FA. Well-differentiated follicular patterned tumors Clin Breast Cancer. 2014;14(4):241-248. IF 2014;28(4):507-518. IF 4.907; Ranking 0.826. Unstimulated highly sensitive thyroglobulin in of the thyroid with high-grade features can 2.628; Ranking 0.482. follow-up of differentiated thyroid cancer patients: metastasize in the absence of capsular or vascular Giovanella L, Clark PM, Chiovato L, Duntas L, Elisei a meta-analysis. invasion: report of a case. Campennì A, Giovanella L, Siracusa M, Stipo ME, R, Feldt-Rasmussen U, Leenhardt L, Luster M, J Clin Endocrinol Metab. 2014;99(2):440-447. IF Int J Surg Pathol. 2014;22(8):749-756. IF 0.961; Alibrandi A, Cucinotta M, Ruggeri RM, Baldari S. Schalin-Jäntti C, Schott M, Seregni E, Rimmele H, 6.31; Ranking 0.901. Ranking 0.269. Is malignant nodule topography an additional Smit J, Verburg FA. risk factor for metastatic disease in low-risk Thyroglobulin measurement using highly sensitive Heinzel A, Müller D, Behrendt FF, Giovanella L, Cafarotti S, Treglia G, Bongiovanni M, Ceriani L, differentiated thyroid cancer? assays in patients with differentiated thyroid Mottaghy FM, Verburg FA. Paone G, Giovanella L, Dutly A. Thyroid. 2014;24(11):1607-1611. IF 3.843; cancer: a clinical position paper. Thyroid nodules with indeterminate A rare case of mucinous cystadenoma of the lung Ranking 0.702. Eur J Endocrinol. 2014;171(2):R33-46. IF 3.686; cytology: molecular imaging with ⁹⁹mTc- mimicking malignancy at 18F-FDG PET/CT. Ranking 0.669. methoxyisobutylisonitrile (MIBI) is more cost- Clin Nucl Med. 2014;39(6):e331-333. IF 2.857; Cistaro A, Pazè F, Durando S, Cogoni M, Faletti effective than the Afirma gene expression Ranking 0.775. R, Vesco S, Vallero S, Quartuccio N, Treglia G, Giovanella L, Giugliano G, Maffini FA, Chiesa F, classifier. Ramenghi U. Bongiovanni M. Eur J Nucl Med Mol Imaging. 2014;41(8):1497- Caldarella C, Annunziata S, Treglia G, Sadeghi R, Autoimmune lymphoproliferative syndrome and Hypercalcitoninemia and thyroid nodules: when 1500. IF 5.217; Ranking 0.95. Ayati N, Giovanella L. non-Hodgkin lymphoma: what 18F-fluorodeoxyglu- cytology (still) matters. Diagnostic performance of positron emission cose positron emission tomography/computed Diagn Cytopathol. 2014;42(11):970-973. IF 1.52; Hosseinnezhad T, Shariati F, Treglia G, Kakhki VR, tomography/computed tomography using tomography can do in the management of these Ranking 0.448. Sadri K, Kianifar HR, Sadeghi R. fluorine-18 fluorodeoxyglucose in detecting patients? Suggestions from a case report. 99mTc-Pertechnetate imaging for detection of locoregional nodal involvement in patients with Rev Esp Med Nucl Imagen Mol. 2014;33(2):99- Ghooshkhanei H, Treglia G, Sabouri G, Davoodi R, ectopic gastric mucosa: a systematic review and anal canal cancer: a systematic review and meta- 102. Sadeghi R. meta-analysis of the pertinent literature. analysis. Risk stratification and prognosis determination Acta Gastroenterol Belg. 2014;77(3):318-327. IF ScientificWorldJournal. 2014;2014:196068. Crescenzi A, Guidobaldi L, Nasrollah N, Taccogna using (18)F-FDG PET imaging in endometrial 0.581. IF 1.219; Ranking 0.727. S, Cicciarella Modica DD, Turrini L, Nigri G, cancer patients: a systematic review and meta- Romanelli F, Valabrega S, Giovanella L, Onetti analysis. Leuzzi G, Facciolo F, Treglia G, Lococo F. Caldarella C, Isgrò MA, Treglia G. Muda A, Trimboli P. Gynecol Oncol. 2014;132(3):669-676. IF 3.687; Bronchial carcinoids with oncocytic features and Bone Marrow Involvement in Hodgkin and Non- Immunohistochemistry for BRAF(V600E) antibody Ranking 0.922. expressing GLUT1 receptor: does the intense (18) Hodgkin Lymphomas: The Role of Fluorine- VE1 performed in core needle biopsy samples F-FDG uptake correlate with long-term survival? 18-Fluorodeoxyglucose Positron Emission identifies mutated papillary thyroid cancers. Giovanella L, Treglia G, Ceriani L, Verburg F. Hell J Nucl Med. 2014;17(2):156. IF 0.925; Tomography/Computed Tomography. Horm Metab Res. 2014;46(5):370-374. IF 2.038; Detectable thyroglobulin with negative imaging in Ranking 0.15. J Bone Marrow Res. 2014,2:e111. Ranking 0.364. differentiated thyroid cancer patients. What to do

114 Scientific Report 2014 7. Publications in 2014 115 Lococo F, Cafarotti S, Filice A, Bertagna F, Treglia Functional imaging evaluation in the detection, Prognostic significance of sentinel lymph node detected by ¹⁸F-FDG-PET/CT. Pancreatology. G. diagnosis, and histologic differentiation of mapping in Merkel cell carcinoma: systematic 2014;14(1):81-82. IF 2.504; Ranking 0.554. A false positive finding on the PET of somatostatin pulmonary neuroendocrine tumors. review and meta-analysis of prognostic studies. receptor due to a chondromyxoid fibroma. Thorac Surg Clin. 2014;24(3):285-292. IF 0.769; Biomed Res Int. 2014;2014:489536. IF 2.706. Treglia G, Bongiovanni M, Giovanella L. Rev Esp Med Nucl Imagen Mol. 2014;33(4):245- Ranking 0.218. Rare sinonasal small cell neuroendocrine carcinoma 246. Sadeghi R, Asadi M, Treglia G, Zakavi SR, Fattahi evaluated by F-18-FDG PET/MRI. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri A, Krag DN. Endocrine. 2014;47(2):654-5. IF 3.527; Ranking Lococo F, Cesario A, de Franco S, Ricchetti T, AJ, Vitolo U, Stelitano C, Brusamolino E, Cabras Axillary concordance between superficial and 0.603. Sgarbi G, Treglia G. MG, Rigacci L, Balzarotti M, Salvi F, Montoto S, deep sentinel node mapping material injections Is 18FDG PET/CT evaluation really useful in the Lopez-Guillermo A, Finolezzi E, Pileri SA, Davies A, in breast cancer patients: systematic review and Treglia G, Caldarella C, Taralli S. diagnosis of elastofibroma dorsi? Rev Esp Med Cavalli F, Giovanella L, Johnson PW. meta-analysis of the literature. A rare case of primary pulmonary synovial Nucl Imagen Mol. 2014;33(1):62. [18F]fluorodeoxyglucose positron emission Breast Cancer Res Treat. 2014;144(2):213-222. sarcoma in a pediatric patient evaluated by (18) tomography predicts survival after IF 4.198; Ranking 0.759. F-FDG PET/CT. Lococo F, Cesario A, Paci M, Filice A, Versari A, chemoimmunotherapy for primary mediastinal Clin Nucl Med. 2014;39(2):e166-168. IF 2.857; Rapicetta C, Ricchetti T, Sgarbi G, Alifano M, large B-cell lymphoma: results of the International Sadeghi R, Asadi M, Treglia G, Zakavi SR, Fattahi Ranking 0.775. Cavazza A, Treglia G. Extranodal Lymphoma Study Group IELSG-26 A, Krag DN. PET/CT assessment of neuroendocrine tumors Study. Determining axillary concordance rate for different Treglia G, Cardillo G, Graziano P. of the lung with special emphasis on bronchial J Clin Oncol. 2014;32(17):1769-1775. IF 17.879; injection locations in sentinel node mapping of A rare case of primary pulmonary epithelioid carcinoids. Ranking 0.98. breast cancer: how ambitious can we get? angiosarcoma detected by (18)F-FDG PET/CT. Tumor Biol. 2014;35(9):8369-8377. IF 2.84; Breast Cancer Res Treat. 2014;146(1):231-232. Clin Nucl Med. 2014;39(5):450-452. IF 2.857; Ranking 0.543. Paci M, Lococo F, Rapicetta C, Roncali M, Cavazza IF 4.198; Ranking 0.759. Ranking 0.775. A, Treglia G, Sgarbi G. Lococo F, Cesario A, Treglia G. Synchronous bilateral bronchial carcinoid Treglia G, Annunziata S, Sobic-Saranovic D, Treglia G, Ceriani L, Barizzi J, Paone G, Giovanella L. Is it time to validate the prognostic role of F-18- diagnosed with combined dual tracer ((18)F-FDG Bertagna F, Caldarella C, Giovanella L. Colorectal carcinoma with bone metastases FDG PET/CT scan in thymic epithelial tumors? and (68)Ga-DOTATOC) PET/CT scans. The role of 18F-FDG-PET and PET/CT in patients detected by 18F-choline PET/CT. Ann Nucl Med. 2014;28(6):593-594. IF 1.507; Rev Esp Med Nucl Imagen Mol. 2014;33(4):247- with sarcoidosis: an updated evidence-based Clin Nucl Med. 2014;39(3):e246-248. IF 2.857; Ranking 0.417. 248. review. Ranking 0.775. Acad Radiol. 2014;21(5):675-684. IF 2.077; Lococo F, Rapicetta C, Ricchetti T, Cavazza A, Filice Paone G, Treglia G, Bongiovanni M, Ceriani L, Ranking 0.625. Treglia G, Ceriani L, Giovanella L. A, Treglia G, Tenconi S, Paci M, Sgarbi G. Giovanella L. An Unusual Case of Extraskeletal Retroperitoneal Diagnostic pitfalls in the preoperative 18F-FDG A rare case of synchronous fetal type Treglia G, Bongiovanni M, Giovanella L. Osteosarcoma Incidentally Detected by (18)F-FDG PET/CT evaluation of a case of giant malignant adenocarcinoma and mucinous adenocarcinoma A rare case of small cell neuroendocrine carcinoma PET/CT. solitary fibrous tumor of the pleura. of the lung evaluated by 18F-FDG PET/CT. of the urinary bladder incidentally detected by Nucl Med Mol Imaging. 2014;48(3):249-250. Rev Esp Med Nucl Imagen Mol. 2014;33(2):109- Clin Nucl Med. 2014;39(8):e384-386. IF 2.857; F-18-FDG PET/CT. 111. Ranking 0.775. Endocrine. 2014;45(1):156-157. IF 3.257; Treglia G, Ceriani L, Giovanella L. Ranking 0.603. Current role and future perspectives of Lococo F, Treglia G. Rokni H, Sadeghi R, Moossavi Z, Treglia G, Zakavi radioiodinated MIBG in the evaluation of dementia Which is the best strategy for diagnosing bronchial SR. Treglia G, Bongiovanni M, Giovanella L. with Lewy bodies. carcinoid tumours? The role of dual tracer PET/ Efficacy of different protocols of radioiodine therapy Metastatic small cell neuroendocrine carcinoma Curr Radiopharm. 2014;7(1):75-78. CT scan. for treatment of toxic nodular goiter: systematic of the pelvic floor. Hell J Nucl Med. 2014;17(1):7-9. IF 0.925; review and meta-analysis of the literature. Endocrine. 2014;46(1):164-165. IF 3.527; Treglia G, Ceriani L, Merlo E, Ruberto T, Paone G, Ranking 0.15. Int J Endocrinol Metab. 2014;12(2):e14424. Ranking 0.603. Giovanella L. Added value of fused somatostatin receptor Lococo F, Treglia G, Cesario A, Paci M, Filice A, Sadeghi R, Adinehpoor Z, Maleki M, Fallahi B, Treglia G, Bongiovanni M, Giovanella L. imaging/magnetic resonance imaging in a rare Versari A, Filosso PL. Giovanella L, Treglia G. Pancreatic small cell carcinoma incidentally case of paraganglioma of the urinary bladder.

116 Scientific Report 2014 7. Publications in 2014 117 Rev Esp Med Nucl Imagen Mol. 2014;33(2):122- gouty arthritis and tophi evaluated by fluorine An unusual case of diffuse large B-cell lymphoma based review. 124. 18 fluorodeoxyglucose positron emission involving the vulva evaluated by 18F-FDG PET/CT. Clin Transl Oncol. 2014;16(9):770-775. IF 1.6; tomography/computed tomography. Clin Nucl Med. 2014;39(10):e439-441. IF 2.857; Ranking 0.216. Treglia G, Ceriani L, Paone G, Rusca T, Bongiovanni J Clin Rheumatol. 2014;20(4):233-234. IF 1.25. Ranking 0.775. M, Giovanella L. Treglia G, Sadeghi R, Giovanella L, Cafarotti S, Multifocal epithelioid hemangioendothelioma of Treglia G, Giovanella L, Muoio B, Caldarella C. Treglia G, Paone G, Stathis A, Ceriani L, Giovanella Filosso P, Lococo F. the lower limbs detected by 18F-FDG PET/MRI. Solitary Plasmacytoma of the Sternum Mimicking L. Is (18)F-FDG PET useful in predicting the WHO Clin Nucl Med. 2014;39(9):e402-404. IF 2.857; Bone Metastasis in a Patient with a History of An Unusual Case of Plasmablastic Lymphoma grade of malignancy in thymic epithelial tumors? Ranking 0.775. Breast Cancer Evaluated by F-18-FDG PET/CT. Presenting as Paravertebral Mass Evaluated by A meta-analysis. Nucl Med Mol Imaging. 2014;48(2):169-170. (18) F-FDG PET/CT. Lung Cancer. 2014;86(1):5-13. IF 3.737; Ranking Treglia G, Ceriani L, Ruberto T, Paone G, Bertagna Nucl Med Mol Imaging. 2014;48(1):89-90. 0.811. F, Giovanella L. Treglia G, Giovanella L, Muoio B, Caldarella C. A case of optic neuritis incidentally detected by Splenosis Mimicking Relapse of a Neuroendocrine Treglia G, Sadeghi R, Annunziata S, Caldarella C, Treglia G, Salvatori M, Giovanella L. somatostatin receptor scintigraphy. Rev Esp Med Tumor at Gallium-68-DOTATOC PET/CT. Bertagna F, Giovanella L. Small cell carcinoma of the thyroid gland with a Nucl Imagen Mol. 2014;33(3):189-190. Nucl Med Mol Imaging. 2014;48(2):163-165. Diagnostic performance of fluorine-18- solid brain metastasis detected by F-18-FDG PET/ fluorodeoxyglucose positron emission tomography CT. Treglia G, Ceriani L, Sadeghi R, Giovacchini G, Treglia G, Muoio B, Caldarella C, Parapatt GK. in the postchemotherapy management of patients Endocrine. 2014;46(3):682-683. IF 3.527; Giovanella L. A pulmonary metastasis of a cystosarcoma with seminoma: systematic review and meta- Ranking 0.603. Relationship between prostate-specific antigen phyllodes of the breast detected by 18F-FDG PET/ analysis. kinetics and detection rate of radiolabelled CT. Biomed Res Int. 2014;2014:852681. IF 2.706. Treglia G, Taralli S, Salsano M, Muoio B, Sadeghi choline PET/CT in restaging prostate cancer Clin Nucl Med. 2014;39(3):e233-235. IF 2.857; R, Giovanella L. patients: a meta-analysis. Clin Chem Lab Med. Ranking 0.775. Treglia G, Sadeghi R, Annunziata S, Lococo F, Prevalence and malignancy risk of focal colorectal 2014;52(5):725-733. IF 2.955; Ranking 0.862. Cafarotti S, Bertagna F, Prior JO, Ceriani L, incidental uptake detected by (18)F-FDG-PET or Treglia G, Oragano L, Fadda G, Raffaelli M, Lombardi Giovanella L. PET/CT: a meta-analysis. Treglia G, Giovanella L, Caldarella C, Bertagna F. CP, Castaldi P, Rufini V. Diagnostic accuracy of 18F-FDG-PET and PET/CT Radiol Oncol. 2014;48(2):99-104. IF 1.667; A rare case of thyroid paraganglioma detected by A rare case of solitary fibrous tumor of the adrenal in the differential diagnosis between malignant and Ranking 0.236. ¹⁸F-FDG PET/CT. gland detected by (18)F-FDG PET/CT. benign pleural lesions: a systematic review and Rev Esp Med Nucl Imagen Mol. 2014;33(5):320- Clin Nucl Med. 2014;39(5):475-477. IF 2.857; meta-analysis. Trimboli P, Cremonini N, Ceriani L, Saggiorato E, 321. Ranking 0.775. Acad Radiol. 2014;21(1):11-20. IF 2.077; Ranking Guidobaldi L, Romanelli F, Ventura C, Laurenti O, 0.625. Messuti I, Solaroli E, Madaio R, Bongiovanni M, Treglia G, Giovanella L, Lococo F. Treglia G, Paone G, Ceriani L, Giovanella L. Orlandi F, Crescenzi A, Valabrega S, Giovanella L. Evolving role of PET/CT with different tracers in the Metastatic brachial plexopathy from breast cancer Treglia G, Sadeghi R, Annunziata S, Lococo F, Calcitonin measurement in aspiration needle evaluation of pulmonary neuroendocrine tumours. detected by 18F-FDG PET/MRI. Rev Esp Med Nucl Cafarotti S, Prior JO, Bertagna F, Ceriani L, washout fluids has higher sensitivity than Eur J Nucl Med Mol Imaging. 2014;41(5):853- Imagen Mol. 2014;33(1):54-55. Giovanella L. cytology in detecting medullary thyroid cancer: a 855. IF 5.217; Ranking 0.95. Diagnostic performance of fluorine-18- retrospective multicentre study. Treglia G, Paone G, Flores B, Venzi G, Ceriani L, fluorodeoxyglucose positron emission tomography Clin Endocrinol (Oxf). 2014;80(1):135-140. IF Treglia G, Giovanella L, Lococo F, Bertagna F. Giovanella L. in the assessment of pleural abnormalities in 3.353; Ranking 0.57. An unusual case of thymic carcinoid causing A rare case of large cell neuroendocrine carcinoma cancer patients: a systematic review and a meta- Cushing's syndrome due to ectopic ACTH secretion of the urinary bladder evaluated by ¹⁸F-FDG-PET/ analysis. Trimboli P, Giovanella L, Crescenzi A, Romanelli F, detected by (18)F-FDG PET/CT. CT. Lung Cancer. 2014;83(1):1-7. IF 3.737; Ranking Valabrega S, Spriano G, Cremonini N, Guglielmi R, Rev Esp Med Nucl Imagen Mol. 2014;33(4):253- Rev Esp Med Nucl Imagen Mol. 2014;33(5):312- 0.811. Papini E. 254. 313. Medullary thyroid cancer diagnosis: an appraisal. Treglia G, Sadeghi R, Del Sole A, Giovanella L. Head Neck. 2014;36(8):1216-1223. IF 3.006. Treglia G, Giovanella L, Muoio B, Bertagna F. Treglia G, Paone G, Perriard U, Ceriani L, Giovanella Diagnostic performance of PET/CT with tracers Response to treatment in a patient with L. other than F-18-FDG in oncology: an evidence- Trimboli P, Giovanella L, Valabrega S, Andrioli

118 Scientific Report 2014 7. Publications in 2014 119 M, Baldelli R, Cremonini N, Rossi F, Guidobaldi L, Oncology L, Fenech D, Francis P, Gelmon K, Giordano SH, Stathis A, Gaidano G, Cavalli F, Zucca E. Barnabei A, Rota F, Paoloni A, Rizza L, Fattorini G, Gligorov J, Goldhirsch A, Harbeck N, Houssami N, Clinical activity of everolimus in relapsed/ Latini M, Ventura C, Falasca P, Orlandi F, Crescenzi Bahleda R, Sessa C, Del Conte G, Gianni L, Capri G, Hudis C, Kaufman B, Krop I, Kyriakides S, Lin UN, refractory marginal zone B-cell lymphomas: results A, D Ambrosio F, Cantisani V, Romanelli F, Negro Varga A, Oprea C, Daglish B, Hospitel M, Soria JC. Mayer M, Merjaver SD, Nordström EB, Pagani O, of a phase II study of the International Extranodal R, Saggiorato E, Appetecchia M. Phase I clinical and pharmacokinetic study of Partridge A, Penault-Llorca F, Piccart MJ, Rugo H, Lymphoma Study Group. Ultrasound features of medullary thyroid ombrabulin (AVE8062) combined with cisplatin/ Sledge G, Thomssen C, Van't Veer L, Vorobiof D, Br J Haematol. 2014 Jul;166(1):69-76. IF 4.959; carcinoma correlate with cancer aggressiveness: docetaxel or carboplatin/paclitaxel in patients Vrieling C, West N, Xu B, Winer E. Ranking 0.853. a retrospective multicenter study. with advanced solid tumors. ESO-ESMO 2nd international consensus guidelines J Exp Clin Cancer Res. 2014;33(1):87. IF 3.271; Invest New Drugs. 2014;32(6):1188-96. IF for advanced breast cancer (ABC2). Cortinovis D, Monica V, Pietrantonio F, Ceresoli GL, Ranking 0.628. 2.927; Ranking 0.679. Ann Oncol. 2014;25(10):1871-1888. IF 6.578; La Spina CM, Wannesson L. Ranking 0.915. MicroRNAs in non-small cell lung cancer: current Trimboli P, Guidobaldi L, Crescenzi A, Bongiovanni Barrington SF, Mikhaeel NG, Kostakoglu L, status and future therapeutic promises. M, Giovanella L. Meignan M, Hutchings M, Müeller SP, Schwartz Cheson BD, Fisher RI, Barrington SF, Cavalli Curr Pharm Des. 2014;20(24):3982-3990. IF The essential use of FNA-calcitonin for detecting LH, Zucca E, Fisher RI, Trotman J, Hoekstra OS, F, Schwartz LH, Zucca E, Lister TA; Alliance, 3.288; Ranking 0.758. medullary thyroid cancer. Hicks RJ, O'Doherty MJ, Hustinx R, Biggi A, Cheson Australasian Leukaemia and Lymphoma Group; Endocrine. 2014;47(1):342-344. IF 3.527; BD. Eastern Cooperative Oncology Group; European Damia G, Sessa C. Ranking 0.603. Role of Imaging in the Staging and Response Mantle Cell Lymphoma Consortium; Italian Success and Limitations of Targeted Cancer Assessment of Lymphoma: Consensus of the Lymphoma Foundation; European Organisation for Therapy in Ovarian Cancer. Trimboli P, Nasrollah N, Guidobaldi L, Taccogna International Conference on Malignant Lymphomas Research; Treatment of Cancer/Dutch Hemato- Prog Tumor Res. 2014;41:89-97. IF 0.25. S, Cicciarella Modica DD, Amendola S, Romanelli Imaging Working Group. Oncology Group; Grupo Español de Médula Ósea; F, Lenzi A, Nigri G, Centanni M, Giovanella L, J Clin Oncol. 2014;32(27):3048-3058. IF 17.879; German High-Grade Lymphoma Study Group; Del Conte G, Sessa C, von Moos R, Viganò L, Valabrega S, Crescenzi A. Ranking 0.98. German Hodgkin's Study Group; Japanese Digena T, Locatelli A, Gallerani E, Fasolo A, Tessari The use of core needle biopsy as first-line in Lymphorra Study Group; Lymphoma Study A, Cathomas R, Gianni L. diagnosis of thyroid nodules reduces false negative Bruno Ventre M, Ferreri AJ, Gospodarowicz M, Govi Association; NCIC Clinical Trials Group; Nordic Phase I study of olaparib in combination with and inconclusive data reported by fine-needle S, Messina C, Porter D, Radford J, Heo DS, Park Y, Lymphoma Study Group; Southwest Oncology liposomal doxorubicin in patients with advanced aspiration. Martinelli G, Taylor E, Lucraft H, Hong A, Scarfò L, Group; United Kingdom National Cancer Research solid tumors. World J Surg Oncol. 2014;12:61. IF 1.2; Ranking Zucca E, Christie D; on behalf of the International Institute. Br J Cancer. 2014;111(4):651-659. IF 4.817; 0.401. Extranodal Lymphoma Study Group (IELSG). Recommendations for Initial Evaluation, Staging, Ranking 0.794. Clinical Features, Management, and Prognosis of an and Response Assessment of Hodgkin and Non- Trimboli P, Treglia G, Guidobaldi L, Saggiorato International Series of 161 Patients With Limited- Hodgkin Lymphoma: The Lugano Classification. Di Lascio S, Pagani O. E, Nigri G, Crescenzi A, Romanelli F, Orlandi F, Stage Diffuse Large B-Cell Lymphoma of the Bone J Clin Oncol. 2014;32(27):3059-3068. IF 17.879; Oligometastatic Breast Cancer: A Shift from Valabrega S, Sadeghi R, Giovanella L. (the IELSG-14 Study). Ranking 0.98. Palliative to Potentially Curative Treatment? Clinical characteristics as predictors of malignancy Oncologist. 2014;19(3):291-298. IF 4.54; Ranking Breast Care (Basel). 2014;9(1):7-14. IF 0.911; in patients with indeterminate thyroid cytology: a 0.784. Coiffier B, Federico M, Caballero D, Dearden C, Ranking 0.13. meta-analysis. Morschhauser F, Jäger U, Trümper L, Zucca E, Endocrine. 2014;46(1):52-59. IF 3.527; Ranking Cafarotti S, Froesch P, Bongiovanni M, Mazzucchelli Gomes da Silva M, Pettengell R, Weidmann E, Di Mitri* D, Toso A*, Chen JJ, Sarti M, Pinton 0.603. L, Martin V, Dutly AE. d'Amore F, Tilly H, Zinzani PL. S, Jost TR, D'Antuono R, Montani E, Garcia- SS18-bronchial biphasic synovial sarcoma in an Therapeutic options in relapsed or refractory Escudero R, Guccini I, Da Silva-Alvarez S, Collado Verburg FA, Heinzel A, Hänscheid H, Mottaghy FM, octogenarian with hemothorax. peripheral T-cell lymphoma. M, Eisenberger M, Zhang Z, Catapano C, Grassi F, Luster M, Giovanella L. Lung. 2014;192(3):451-453. IF 2.171; Ranking Cancer Treat Rev. 2014;40(9):1080-1088. IF Alimonti A. Nothing new under the nuclear sun: towards 80 0.377. 6.466; Ranking 0.91. Tumour-infiltrating Gr-1+ myeloid cells antagonize years of theranostics in nuclear medicine. senescence in cancer. Eur J Nucl Med Mol Imaging. 2014;41(2):199- Cardoso F, Costa A, Norton L, Senkus E, Aapro M, Conconi A, Raderer M, Franceschetti S, Devizzi Nature. 2014;515(7525):134-137. IF 42.351; 201. IF 5.217; Ranking 0.95. André F, Barrios CH, Bergh J, Biganzoli L, Blackwell L, Ferreri AJ, Magagnoli M, Arcaini L, Zinzani PL, Ranking 1. KL, Cardoso MJ, Cufer T, El Saghir N, Fallowfield Martinelli G, Vitolo U, Kiesewetter B, Porro E, (*DMD and TA contributed equally)

120 Scientific Report 2014 7. Publications in 2014 121 Domingues D, Turner A, Silva MD, Marques DS, Zucca E, Gospodarowicz M, Ferreri AJ; on behalf Park HY, Pro B, Jayamohan J, Visco C, Scarfò D, Peccatori F, Kaufmann B, Cardoso F. Mellidez JC, Wannesson L, Mountzios G, de Mello of the International Extranodal Lymphoma Study L, Zucca E, Gospodarowicz M, Christie D; the First international consensus guidelines for RA. Group (I.E.L.S.G.). International Extranodal Lymphoma Study Group breast cancer in young women (BCY1). Breast. Immunotherapy and lung cancer: current The clinical features, management and prognostic (I.E.L.S.G.). 2014;23(3):209-220. IF 2.581; Ranking 0.792. developments and novel targeted therapies. effects of pathological fractures in a multicenter Clinical features, management and prognosis of Immunotherapy. 2014;6(11):1221-1235. IF series of 373 patients with diffuse large B-cell multifocal primary bone lymphoma: a retrospective Pittoni P, Di Lascio S, Conti-Beltraminelli M, Valli 2.44. lymphoma of the bone. study of the international extranodal lymphoma MC, Espeli V, Bongiovanni M, Richetti A, Pagani O. Ann Oncol. 2014 Jan;25(1):176-181. IF 6.578; study group (the IELSG 14 study). Paranasal sinus metastasis of breast cancer. Dreyling M, Ghielmini M, Marcus R, Salles G, Vitolo Ranking 0.915. Br J Haematol. 2014 Mar;164(6):834-40. IF BMJ Case Rep. 2014;2014. U, Ladetto M; ESMO Guidelines Working Group. 4.959; Ranking 0.853. Newly diagnosed and relapsed follicular lymphoma: Lennerz V, Gross S, Gallerani E, Sessa C, Mach Senkus E, Cardoso F, Pagani O. ESMO Clinical Practice Guidelines for diagnosis, N, Boehm S, Hess D, von Boehmer L, Knuth Mian M, Kwee I, Rinaldi A, Ponzoni M, Bhagat G, Time for more optimism in metastatic breast treatment and follow-up. A, Ochsenbein AF, Gnad-Vogt U, Zieschang J, Rossi D, Arcaini L, Gascoyne RD, Mollejo M, Baldini cancer? Ann Oncol. 2014;25 Suppl 3:iii76-82. IF 6.578; Forssmann U, Woelfel T, Kaempgen E. L, Thieblemont C, Gaidano G, Zucca E, Bertoni F. Cancer Treat Rev. 2014;40(2):220-228. IF 6.466; Ranking 0.915. Immunologic response to the sruvivin-derived Genome-wide DNA profiling identifies clonal Ranking 0.91. multi-epitope vaccine EMD640744 in pazients heterogeneity in marginal zone lymphomas. Ferreri AJ, Gospodarowicz M, Zucca E, Christie D. with advanced solid tumors. Br J Haematol. 2014;164(6):896-899. IF 4.959; Toso A, Revandkar A, Di Mitri D, Guccini I, Proietti In reply. Cancer Immunol Immunother. 2014;63(4):381- Ranking 0.853. M, Sarti M, Pinton S, Zhang J, Kalathur M, Civenni Oncologist. 2014;19(12):1289-1290. 94. IF 3.943; Ranking 0.734. G, Jarrossay D, Montani E, Marini C, Garcia- IF 4.54; Ranking 0.784. Nabhan C, Ollberding NJ, Villines D, Chiu BC, Caces Escudero R, Scanziani E, Grassi F, Pandolfi PP, Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri DB, Valdez TV, Ghielmini M, Hsu Schmitz SF, Smith Catapano CV, Alimonti A. Froesch P, Martucci F, Györik S, Dutly AE, Cafarotti AJ, Vitolo U, Stelitano C, Brusamolino E, Cabras SM. Enhancing chemotherapy efficacy in Pten-deficient S. MG, Rigacci L, Balzarotti M, Salvi F, Montoto S, A systematic review of comparative schedule- prostate tumors by activating the senescence- Management of non-small cell lung cancer in the Lopez-Guillermo A, Finolezzi E, Pileri SA, Davies A, related toxicities with maintenance rituximab in associated antitumor immunity. elderly. Cavalli F, Giovanella L, Johnson PW. follicular and mantle cell lymphomas. Cell Rep. 2014;9(1):75-89. IF 7.21. Eur J Intern Med. 2014;25(10):888-894. [18F]Fluorodeoxyglucose Positron Emission Leuk Lymphoma. 2014;55(6):1288-94. IF 2.605; IF 2.3; Ranking 0.758. Tomography Predicts Survival After Ranking 0.574. Treglia G, Paone G, Stathis A, Ceriani L, Giovanella Chemoimmunotherapy for Primary Mediastinal L. Govi S, Christie D, Mappa S, Marturano E, Bruno Large B-Cell Lymphoma: Results of the Pagani O, Regan MM, Walley BA, Fleming GF, An Unusual Case of Plasmablastic Lymphoma Ventre M, Messina C, Gracia Medina EA, Porter International Extranodal Lymphoma Study Group Colleoni M, Láng I, Gomez HL, Tondini C, Burstein Presenting as Paravertebral Mass Evaluated by D, Radford J, Heo DS, Park Y, Pro B, Jayamohan IELSG-26 Study. HJ, Perez EA, Ciruelos E, Stearns V, Bonnefoi (18) F-FDG PET/CT. J, Pavlakis N, Zucca E, Gospodarowicz M, Ferreri J Clin Oncol. 2014 Jun 10;32(17):1769-75. IF HR, Martino S, Geyer CE Jr, Pinotti G, Puglisi F, Nucl Med Mol Imaging. 2014;48(1):89-90. AJ; on behalf of the International Extranodal 17.879; Ranking 0.98. Crivellari D, Ruhstaller T, Winer EP, Rabaglio- Lymphoma Study Group (I.E.L.S.G.). Poretti M, Maibach R, Ruepp B, Giobbie-Hurder Vannata B, Zucca E. The clinical features, management and prognosis Martin V, Zanellato E, Franzetti-Pellanda A, Molinari A, Price KN, Bernhard J, Luo W, Ribi K, Viale G, Hepatitis C virus-associated B-cell non-Hodgkin of primary and secondary indolent lymphoma of F, Movilia A, Paganotti A, Deantonio L, De Dosso S, Coates AS, Gelber RD, Goldhirsch A, Francis PA; lymphomas. the bone: a retrospective study of the international Assi A, Crippa S, Boldorini R, Mazzucchelli L, Saletti TEXT and SOFT Investigators; International Breast Hematology Am Soc Hematol Educ Program. extranodal lymphoma study group (the IELSG #14 P, Frattini M. Cancer Study Group. 2014;2014(1):590-598. IF 2.857. study). EGFR, KRAS, BRAF, and PIK3CA characterization Adjuvant Exemestane with Ovarian Suppression Leuk Lymphoma 2014;55(8):1796-1799. IF in squamous cell anal cancer. in Premenopausal Breast Cancer. N Engl J Med. von Hohenstaufen KA, Conconi A, de Campos CP, 2.605; Ranking 0.574. Histol Histopathol. 2014;29(4):513-21. IF 2.236; 2014;371(2):107-118. IF 54.42; Ranking 1. Zucca E. Ranking 0.566. Prognostic impact of monocyte count at Govi S, Christie D, Messina C, Bruno Ventre M, Partridge AH, Pagani O, Abulkhair O, Aebi S, Amant presentation in mantle cell lymphoma - response Gracia Medina EA, Porter D, Radford J, Heo DS, Messina C, Ferreri AJ, Govi S, Bruno-Ventre M, F, Azim HA Jr, Costa A, Delaloge S, Freilich G, to Anupkumar et al. Park Y, Martinelli G, Taylor E, Lucraft H, Ballova V, Gracia Medina EA, Porter D, Radford J, Heo DS, Gentilini OD, Harbeck N, Kelly CM, Loibl S, Meirow Br J Haematol. 2014;164(6):893-894. IF 4.959;

122 Scientific Report 2014 7. Publications in 2014 123 Ranking 0.853. Camozzi P, Milani GP, Bianchetti MG. Mauri MC, Agostoni C, Fossali EF. Paediatric surgery Leukotriene receptor antagonists in Henoch- Arterial hypertension and posterior reversible Wannesson L, Viteri S, Costa C, Karachaliou N, Schönlein syndrome: friends or foes? Pediatr Int. cerebral edema syndrome induced by risperidone. Christen S, Mendoza M, Gobet R, Bode P, Weber Molina-Vila MA, Rosell R. 2014;56(5):802. IF 0.731; Ranking 0.152. Paediatrics. 2014;133(3):e771--e774. IF 5.297; D. Signaling pathways modulating dependence of Ranking 0.991. Late ureteral obstruction after injection of lung cancer on mutant epidermal growth factor Capobianco S, Lava SAG, Bianchetti MG, Martinet dextranomer/hyaluronic acid copolymer. receptor and mechanisms of intrinsic and acquired D, Belfiore M, Ramelli GP, Ferrarini A. Ramelli V, Ramelli GP, Lava SAG, Siegenthaler GM, Urology 2014;83(4):920-922. IF 2.132; Ranking resistance to tyrosine kinase inhibitors. Chromosomal microarray among children with Cantù M, Bianchetti MG, Ceschi A. 0.644. Curr Pharm Des. 2014;20(24):3883-3893. IF intellectual disability: a useful diagnostic tool for Vitamin D status among children and adolescents 3.288; Ranking 0.758. the clinical geneticist. on anticonvulsant drugs in southern Switzerland. Cravino M, Canavese F, De Rosa V, Marengo L, Dev Med Child Neurol. 2014;56(3):290. IF 3.292; Swiss Med Wkly. 2014;144:w13996. IF 1.877; Samba A, Rousset M, Mansour Khamallah M, Zucca E, Bertoni F, Vannata B, Cavalli F. Ranking 0.938. Ranking 0.678. Andreacchio A. Emerging Role of Infectious Etiologies in the Outcome of displaced distal tibial metaphyseal Pathogenesis of Marginal Zone B-cell Lymphomas. Dell’Orto V, Bernasconi E, Pezzoli V, Queirolo S, Scurati-Manzoni E, Fossali EF, Agostoni C, Riva fractures in children between 6 and 15 years of Clin Cancer Res. 2014;20(20):5207-5216. IF Ramelli GP. E, Simonetti GD, Zanolari-Calderari M, Bianchetti age treated by elastic stable intramedullary nails. 8.193; Ranking 0.94. Severe, life-threatening Epstein-Barr Virus MG, Lava SAG. Eur J Orthop Surg Traumatol. 2014;24(8):1603- encephalitis in an immunocompetent adolescent Electrolyte abnormalities in cystic fibrosis: 1608. IF 0.18. Zucca E, Stathis A, Bertoni F. girl. systematic review of the literature. The management of nongastric MALT lymphomas. J Pediatr Neurol 2014;12:217–219. Pediatr Nephrol. 2014;29(6):1015-1023. IF Palliative Care Oncology (Williston Park). 2014;28(1):86-93. IF 2.881; Ranking 0.875. 2.981; Ranking 0.598. Ferrarini A, Gaillard M, Guerry F, Ramelli G, Heidi F, Gamondi C, Borasio GD, Limoni C, Preston N, Keddache CV, Wieland I, Beckmann JS, Jaquemont Siegenthaler GM, Rizzi M, Bettinelli A, Simonetti Payne S. Paediatrics S, Martinet D. GD, Ferrarini A, Bianchetti MG. Legalisation of assisted suicide: a safeguard to Potocki-Shaffer deletion encompassing ALX4 in a Ureteral or vesical involvement in Henoch- euthanasia? Bettinelli A, Viganò C, Provero MC, Barretta F, patient with frontonasal dysplasia phenotype. Schönlein syndrome: a systematic review of the Lancet. 2014; 384: 127. IF 39.207; Ranking Albisetti A, Tedeschi S, Scicchitano B, Bianchetti Am J Med Genet A. 2014;164A(2):346-352. IF literature. 0.993. MG. 2.048; Ranking 0.352. Pediatr Nephrol. 2014;29(2):235-239. IF 2.881; Phosphate homeostasis in Bartter syndrome: a Ranking 0.875. Radiology case-control study. Ferrarini A, Lava SAG, Simonetti GD, Ramelli GP, Pediatr Nephrol. 2014;29(11):2133-2138. IF Bianchetti MG; Swiss Italian Society of Paediatrics. Studer M, Boltshauser E, Capone Mori A, Datta A, Bongiovanni M, Vitale VA, Grassi P, Mazzucchelli L. 2.881; Ranking 0.875. Influenzavirus B-associated acute benign myalgia Fluss J, Mercati D, Hackenberg A, Keller E, Maier Malignant mixed müllerian tumor with an extensive cruris: an outbreak report and review of the O, Marcoz JP, Ramelli GP, Poloni C, Schmid R, squamous-cell carcinomatous component: a Bianchetti MG, Bettinelli A, Fossali EF, Faré literature. Schmitt-Mechelke T, Wehrli E, Heinks T, Steinlin M. potential pitfall in liquid-based cervical cytology. PB, Milani GP, Lavagno C, Lava SAG. Chalk Neuromuscul Disord. 2014;24(4):342-346. IF Factors affecting cognitive outcome in early Acta Cytol. 2014;58(4):413-418. IF 1.562; and blackboard interactive 2-day workshop for 3.134; Ranking 0.723. pediatric stroke. Ranking 0.303. pediatricians in training and medical students: Neurology. 2014;82(9):784-792. IF 8.303; preliminary experience. Le Gal F, Lebon S, Ramelli GP, Datta AN, Mercati D, Ranking 0.963. Bordoni A, Cerny A, Bihl F, Alerci M, Mazzola P, J Pers Med. 2014;12:68-72. Maier O, Combescure C, Rodriguez MI, Seeck M, Peverelli S, Marini G, Majno P, Mazzucchelli L, Roulet E, Korff CM. Uestuener P, Ferrarini A, Santi M, Mardegan C, Spitale A. Dell'Orto VG, Belotti EA, Goeggel-Simonetti B, When is a child with status epilepticus likely to Bianchetti MG, Simonetti GD, Milani GP, Lava SAG. Survival of hepatocellular carcinoma patients is Simonetti GD, Ramelli GP, Bianchetti MG, Lava have Dravet syndrome? Taste acceptability of pulverized brand-name significantly improving: a population-based study SAG. Epilepsy Res. 2014;108(4):740-247. IF 2.19; and generic drugs containing amlodipine or from southern Switzerland. Metabolic disturbances and renal stone promotion Ranking 0.503. candesartan. Cancer Epidemiol. 2014;38(6):679-685. IF 2.558; on treatment with topiramate: a systematic review. Int J Pharm. 2014;468(1-2):196-198. IF 3.785; Ranking 0.804. Br J Clin Pharmacol. 2014;77(6):958-64. IF 3.688. Milani GP, Bianchetti MG, Mazzoni MB, Triulzi F, Ranking 0.825.

124 Scientific Report 2014 7. Publications in 2014 125 Del Grande M, Del Grande F, Carrino J, Bingham Radiation Oncology lung or prostate cancer. 1945. IF 3.009; Ranking 0.603. CO 3rd, Louie GH. Radiother Oncol. 2014;113(3):385-391. IF Cervical spine involvement early in the course of Abacioglu U, Ozen Z, Yilmaz M, Arifoglu A, Gunhan 4.857; Ranking 0.933. Stroom J, Vieira S, Mateus D, Greco C, Fogliata A, rheumatoid arthritis. B, Kayalilar N, Peker S, Sengoz M, Gurdalli S, Cozzi Nicolini G, Clivio A, Vanetti E, Cozzi L. Semin Arthritis Rheum. 2014;43(6):738-744. IF L. Fogliata A, Wang PM, Belosi F, Clivio A, Nicolini G, On the robustness of VMAT-SABR treatment plans 3.629; Ranking 0.733. Critical appraisal of RapidArc radiosurgery with Vanetti E, Cozzi L. against isocentre positioning uncertainties. flattening filter free photon beams for benign brain Assessment of a model based optimization engine Radiat Oncol. 2014;9:196. IF 2.36; Ranking Del Grande F, Farahani SJ, Carrino JA, Chhabra A. lesions in comparison to GammaKnife: a treatment for volumetric modulated arc therapy for patients 0.683. Bone marrow lesions: A systematic diagnostic planning study. with advanced hepatocellular cancer. approach. Radiat Oncol. 2014;9:119. IF 2.36; Ranking Radiat Oncol. 2014 Oct 28;9(1):236. IF 2.36; Tozzi A, Cozzi L, Iftode C, Ascolese A, Campisi MC, Indian J Radiol Imaging. 2014 Jul;24(3):279-287. 0.683. Ranking 0.683. Clerici E, Comito T, De Rose F, Fogliata A, Franzese Del Grande F, Santini F, Herzka DA, Aro MR, Dean C, Mancosu P, Navarria P, Tomatis S, Villa E, CW, Gold GE, Carrino JA. Belosi MF, Rodriguez M, Fogliata A, Cozzi L, Mancosu P, Reggiori G, Alongi F, Cozzi L, Fogliata Scorsetti M. Fat-suppression techniques for 3-T MR imaging of Sempau J, Clivio A, Nicolini G, Vanetti E, Krauss A, Lobefalo F, Navarria P, Stravato A, Tomatis S, Radiation therapy of anal canal cancer: from the musculoskeletal system. H, Khamphan C, Fenoglietto P, Puxeu J, Fedele D, Scorsetti M. conformal therapy to volumetric modulated arc Radiographics. 2014;34(1):217-233. I Mancosu P, Brualla L. Total monitor units influence on plan quality therapy. F 2.729; Ranking 0.725. Monte Carlo simulation of TrueBeam flattening- parameters in volumetric modulated arc therapy BMC Cancer. 2014 Nov 18;14:833. IF 3.319; filter-free beams using varian phase-space files: for breast case. Ranking 0.638. Del Grande F, Subhawong T, Flammang A, Fayad comparison with experimental data. Phys Med. 2014;30(3):296-300. IF 1.849; LM. Med Phys. 2014 May;41(5):051707. IF 3.012; Ranking 0.583. Wang PM, Hsu WC, Chung NN, Chang FL, Jang Chemical shift imaging at 3 Tesla: effect of echo Ranking 0.8. CJ, Fogliata A, Scorsetti M, Cozzi L. time on assessing bone marrow abnormalities. Navarria P, Ascolese AM, Tomatis S, Cozzi L, De Feasibility of stereotactic body radiation therapy Skeletal Radiol. 2014;43(8):1139-1147. IF 1.743; Clivio A, Belosi MF, Cozzi L, Nicolini G, Vanetti E, Rose F, Mancosu P, Alongi F, Clerici E, Lobefalo F, with volumetric modulated arc therapy and Ranking 0.525. Bolard G, Fenoglietto P, Krauss H, Fogliata A. Tozzi A, Reggiori G, Fogliata A, Scorsetti M. high intensity photon beams for hepatocellular On the determination of reference levels for quality Stereotactic body radiotherapy (SBRT) in lung carcinoma patients. Del Grande F, Subhawong T, Weber K, Aro M, assurance of flattening filter free photon beams in oligometastatic patients: role of local treatments. Radiat Oncol. 2014;9:18. IF 2.36; Ranking 0.683. Mugera C, Fayad LM. radiation therapy. Radiat Oncol. 2014;9(1):91. IF 2.36; Ranking Detection of soft-tissue sarcoma recurrence: added Med Phys. 2014;41(2):021713. IF 3.012; 0.683. Surgery value of functional MR imaging techniques at 3.0 T. Ranking 0.8. Radiology. 2014;271(2):499-511. IF 6.214; Scorsetti M, Alongi F, Clerici E, Comito T, Fogliata Corni V, Lucchina S, Fusetti C. Ranking 0.975. Comito T, Cozzi L, Clerici E, Campisi MC, Liardo A, Iftode C, Mancosu P, Navarria P, Reggiori G, Is Masson's tumour only a slow-growing benign RL, Navarria P, Ascolese A, Tozzi A, Iftode C, De Tomatis S, Villa E, Cozzi L. neoplasm? A case report. Del Grande F, Tatizawa-Shiga N, Jalali Farahani S, Rose F, Villa E, Personeni N, Rimassa L, Santoro Stereotactic body radiotherapy with flattening Hand Surg. 2014;19(3):445-447. Chalian M, Fayad LM. A, Fogliata A, Mancosu P, Tomatis S, Scorsetti M. filter-free beams for prostate cancer: assessment Chemical shift imaging: preliminary experience as Stereotactic Ablative Radiotherapy (SABR) in of patient-reported quality of life. Cristaudi A, Matthey-Gié ML, Demartines N, an alternative sequence for defining the extent of inoperable oligometastatic disease from colorectal J Cancer Res Clin Oncol. 2014;140(10):1795- Christoforidis D. a bone tumor. cancer: a safe and effective approach. 800. IF 3.009; Ranking 0.603. Prospective Assessment of Trocar-Specific Quant Imaging Med Surg. 2014;4(3):173-180. BMC Cancer. 2014;14:619. IF 3.319; Ranking Morbidity in Laparoscopy. 0.638. Scorsetti M, Navarria P, De Rose F, Ascolese World J Surg, 2014;38(12):3089-3096. IF Dreizin D, Ahlawat S, Del Grande F, Fayad LM. A, Clerici E, Franzese C, Lobefalo F, Reggiori G, 2.348; Ranking 0.726. Gradient-echo in-phase and opposed-phase Fogliata A, Belosi F, Clivio A, Navarria P, Nicolini G, Mancosu P, Tomatis S, Fogliata A, Cozzi L. chemical shift imaging: role in evaluating bone Scorsetti M, Vanetti E, Cozzi L. Outcome and toxicity profiles in the treatment Farid KJ, Gefen A, Harder Y, Iaizzo P, Cullifford marrow. On the pre-clinical validation of a commercial of locally advanced lung cancer with volumetric AT4th, Scheiner J, Bajaj S. Clin Radiol. 2014;69(6):648-657. IF 1.663; model-based optimisation engine: Application to modulated arc therapy. Highlights from the International Forum on Deep Ranking 0.483. volumetric modulated arc therapy for patients with J Cancer Res Clin Oncol. 2014;140(11):1937- Tissue Injury Evolution: A Research-based Scientific

126 Scientific Report 2014 7. Publications in 2014 127 Collaborative. Nebiker C, Han J, Eppenberger-Castori S, Iezzi Tröster B, Fusetti C. Dermatology Ostomy Wound Manage 2014;60(2): 18-28. IF G, Hirt C, Amicarella F, Cremonesi E, Huber X, Muss das Vieleckbein bei der Sattelgelenksarthrose 1.299; Ranking 0.416. Padovan E, Angrisani B, Droeser R A, Rosso R, immer entfernt worden? [Is it necessary to remove Bertoli R, Mondino C, Andreocchi L, Bernasconi E, Bolli M, Oertli D, von Holzen U, Adamina M, Muraro the whole trapezium in thumb osteoarthritis]. Mainetti C. Garofalo F, Christoforidis D, Di Summa PG, Gay M G, Memgus C, Zajac P, Sconocchia G, Zuber M, Ther Umsch. 2014;71(7):410-414. Fotosensibilità ai farmaci. B, Cherix S, Raffoul W, Demartines N, Matter M. Tornillo L, Terracciano L, Spagnoli GC. Tribuna Medica Ticinese 2014,79(12):303-307. The unresolved case of sacral chordoma: from GM – CSF production by tumor cells is associated Van den Berg J, Pedrotti M, Canevascini R, misdiagnosis to challenging surgery and medical with improved survival in colorectal cancer. Chimchila Chevili S, Giovannacci L, Rosso R. Nuclear Medicine therapy resistance. Clin Cancer Res. 2014;20(12):3094-106. IF In-stent restenosis: mid-term results of debulking Ann Coloproctol. 2014;30(3):122-31. 8.193; Ranking 0.94. using excimer laser and drug-eluting balloons: Treglia G, Ceriani L, Giovanella L. sustained benefit? F-18-DOPA PET/CT revealed a neuroendocrine Harder Y, Allan AA, Eder M, Kovacs L, Schantz JT, Posabella A, Galetti K, Engelberger S, Giovannacci J Invasive Cardiol 2014;26(7):333-337. IF 0.824; tumor located in an unusual site. Machens HG. L, Gyr T, Rosso R. Ranking: 0.139. Schweizer Krebsbulletin. 2014;34:267-268. Eigenfetttransfer zur Korrektur von erworbenen A huge mucinous cystadenoma of ovarian: a rare Zanisi L, Fraulini C, Salsano F, Mazzucchelli L, Konturdefekten und Volumenasymmetrien nach case report and review of the literature. Winkler T, Dai XY, Mielke G, Vogt S, Buechner H, Paone G, Pedrazzini A. rekonstruktiven Brusteingriffen. Rare Tumors 2014; 6(2):5225. Schantz JT, Harder Y, Machens HG, Morlock MM, Patologia in pillole Nr. 88. Carcinoma follicolare Plastische Chirurgie 2014; 1:26-36. Schilling AF. della variante oncocitica in struma ovarii. Reckhenrich AK, Kirsch BM, Wahl EA, Schenck Three-dimensional quantification of calcium salt- Tribuna medica ticinese. 2014;79:159-161. Largo RD, Tchang LAH, Mele V, Scherberich A, TL, Rezaeian F, Harder Y, Foehr P, Machens HG, composite resorption (CSC) in vitro by micro- Harder Y, Wettstein R, Schaefer DJ. Egana JT. computed tomography (micro-CT). Nursing Medicine Efficacy, safety, and complications of autologous Surgical sutures filled with adipose-derived stem JOM. 2014; 66(4):559-565. fat grafting to healthy breast tissue: A systematic cells promote wound healing. Walther-Veri S, Bernardi-Zucca I. review. PLOS One. 2014; 9(3): e91169. IF 3.534; Ranking Wettstein R, Tchang LAH, Largo RD, Schantz JT, Giornata di studio organizzata da SUPSI, la J Plast Reconstr Aesthet Surg. 2014 67(4):437- 0.873. Machens HG, Schaefer DJ, Harder Y. Plateforme latine de recherche en soins palliatifs 448. IF 1.474. Eigenfettgewebetransplantation und Brustkrebs: et fin de vie e l’Ente Ospedaliero Cantonale di Ticino. Schantz JT, Harder Y, Largo R, Müller D, Was wissen wir heute? Palliative ch. 2014;3:38-39. Lee JT, Marquez TT, Clerc D, Gie O, Demartines Wettstein R, Tchang LA, Schaefer DJ, Machens Plastische Chirurgie 2014;2:81-86. N, Madoff RD, Rothenberger DA, Christoforidis D. HG, Hutmacher DW. Willems Cavalli Y. Pursestring closure of the stoma site leads to Gewinnung, Aufbereitung und Applikation autologer Publications in non-peer-reviewed journals in Pflege in der Rehabilitation: Veränderungen und fewer wound infections: results from a multicenter Fettzellen. 2014 Zukunftsaussichten am Beispiel Tessin. randomized controlled trial. Plastische Chirurgie 2014;2:87-92. H+ Hospital Forum Competence 2014;(10):36. Dis Colon Rectum. 2014;57(11):1282-1289. IF Internal Medicine 3.198; Ranking 0.893. Schmauss D, Harder Y, Machens HG, Lohmeyer Oncology JA. Bertoli R, Andreocchi L, Franscella S, Bernasconi E. Lucchina S, Fusetti C. Rapidly growing histologicall confirmed female Ginecomastia da farmaci. Pascale M, Marongiu B, Pesce G, Barizzi J, A touch of humanity. Hands on stamps: Brazil breast in a genotypically confirmed male. Tribuna Medica Ticinese 2014;79(9):225-227. Wyttenbach R, Treglia G, Bordoni A, Stoffel F, 1979- 150th Anniversary of the first publication J Plast Reconstr Aesthet Surg. 2014 67(4):e114- Roggero E. in Braille Writing. 115. IF 1.474. Canonica-Lepori A, Andreocchi L, Bissig M, Gestione multidisciplinare dei pazienti con tumori J Hand Surg Am. 2014;39(2):345. IF 1.655; Bernasconi E. urogenitali presso l'ente ospedaliero cantonale. Ranking 0.589. Schmauss D, Wettstein R, Tobalem M, Machens Favismo: fave, ma non solo! Tribuna medica ticinese. 2014; 79:245-248. HG, Rezaeian F, Harder Y. New Treatment Tribuna Medica Ticinese 2014;79(1):23-26. Müller D, Kwak MS, Rezaeian F, Harder Y. Strategies to reduce Burn Wound Progression. Palliative Care Das chronische Lymphödem und seine Neue Behandlungsstrategien zur Verringerung Poncini G, Pironi M, Parlato S, Bertoli R, Monotti R. rekonstruktive Therapie. der Brandwundenprogression. Vitamina B12. Pereira Mestre R, Stelmes JJ, Azinwi NC, Pesce G, Onkologie 2014; 4:262-264. IF 0.835; Ranking 0.055. GMS Ger Plast Reconstr Aesthet Surg 2014 4:1-12. Tribuna Medica Ticinese 2014;79(2):59-62. Cartolari R, Sanna P.

128 Scientific Report 2014 7. Publications in 2014 129 Multidisciplinary management of bone metastases Eigenfettgewebetransplantation in die Brust, ja Poster: PROtocolized Care to Reduce HYpotension in pregnancy (CPP2014). in advanced cancer care. aber. after Spinal Anesthesia (ProCRHYSA randomized Oral communication: Aortic dissection in the third Schweizer Krebsbulletin 2014;34(3):203-208. Schweizerisches Medizin-Forum trial): Statistical Plan. trimester of preganancy in a pluriparus without 2014;14(49):954-956. Antwerp, Belgium, 27th-29th November 2014. risk factors. Radiation Oncology Venice, Italy, 20th-23rd February 2014. Communications at medical conference in Saporito A, Lo Piccolo A, Franceschini D, Tomasetti Pittoni P, Valli MC, Richetti A. 2014 R, Anselmi L. Hurni Y, Vigo F, Lipp Von Wattenwyl BM, Il carcinoma dell’endometrio Qual è il ruolo della Third annual World Congress on Ultrasound in Ochsenbein-Kölble N, Canonica C. radioterapia oggi? Anaesthesiology Medical Education (WCUME). 16. Kongress der Deutsche Gesellschaft für Onkologiepflege 2014 March. Poster: Thoracic ultrasound for confirmation of Pränatal und Geburtsmedizin DGPGM. Ceruti S, Peruzzo M, Franceschini D, De Vivo S, Lo correct lung exclusion before one lung ventilation Poster: Fetal Cholelithiasis: Antenatal diagnosis Physical medicine and rehabilitation Piccolo A, De Bianchi D, Anselmi L, Saporito A. in thoracic surgery. and neonatal follow-up in a case of twin pregnancy Third annual World Congress on Ultrasound in Portland, Oregon (USA), 9th-12th October 2014. - A case report and review of the literature. Manelli A, Schiavone N, Vapino G, Beghello L, Cipolli Medical Education (WCUME). Bonn, Germany, 14th-16th May 2014. A, Trucco E. Oral communication: PROtocolized Care to Reduce Geriatrics Osservazioni sull'uso di resistenze elastiche HYpotension after Spinal Anesthesia (ProCRHYSA Hurni Y, Vigo F, Lipp Von Wattenwyl BM, e pneumatiche nella riabilitazione della spalla randomized trial). Quadri P, Levorato A, Meroni F, Bolliger I, Rocchi S, Ochsenbein-Kölble N, Canonica C. operata di cuffia dei rotatori. Portland, Oregon (USA), 9th-12th October 2014. Zanda E, Zemp D, Tettamanti M, Lucca U. SGGG Jahreskongress gynécologie suisse 2014. La Riabilitazione. 2014;1 vol. XLVIII. Alzheimer's Association International Conference Poster: Fetal Cholelithiasis: Antenatal diagnosis Ceruti S, Peruzzo M, Minotti B, Franceschini D, 2014. and neonatal follow-up in a case of twin pregnancy Marti C, Prigione G, Manelli A, Schiavone N. De Vivo S, Lo Piccolo A, De Bianchi D, Anselmi L, Poster: Association of gait and balance with - A case report and review of the literature. Approccio riabilitativo nel paziente oncologico in Saporito A. incidence od dementia in a population of mildly Interlaken, Switzerland, 25th-27th June 2014. ambito degenziale. Congresso Nazionale della Società Italiana di cognitively impaired patients: the Canton Ticino La Riabilitazione. 2014;1 vol. XLIII. Anestesia, Analgesia e Rianimazione e Terapia Study. Montagna G, Meani F, Zgraggen L, Polli C, Intensiva (SIAARTI). Copenhagen, Denmark, 12th–17th July 2014. Filippakos F, Gyr T. Surgery Oral communication: PROtocolized Care to Reduce Published in: Alzheimer’s & Dementia 2014; SGGG Jahreskongress gynécologie suisse 2014. HYpotension after Spinal Anesthesia (ProCRHYSA 10(Issue 4 Suppl): P745. Poster: Laparoendoscopic single-site surgery Candrian C, Schiavone N, Del Grande F, Marbach randomized trial). (LESS) for adnexal masses: our experience. F, Walch G. Venice, Italy, 22nd-25th October 2014. Gynaecology Interlaken, Switzerland, 25th-27th June 2014. La periartropatia omeroscapolare non esiste la tendinite calcarea. Ceruti S, Peruzzo M, Minotti B, Franceschini D, Cattoni E, Meani F, Mazzucchelli L, Canonica C, Intensive Care Medicine Tribuna Medica Ticinese 2014;79(5):147-149. De Vivo S, Lo Piccolo A, De Bianchi D, Anselmi L, Caccia G, Wyss D, Richetti L, Gyr T. Saporito A. SGGG Jahreskongress gynécologie suisse 2014. Comery A, Bocchi A, Degiorgi A, Ghanfili E, Conti M, Candrian C, Schiavone N, Del Grande F, Marbach 10th Winfocus World Congress. Poster: Ductal Carcinoma in situ influences the Malacrida R, Merlani P. Assemblée annuelle SGI- F, Walch G. Poster: PROtocolized Care to Reduce HYpotension reoperation rates of breast cancer patients. SSMI 2014. La periartropatia omeroscapolare – le patologie after Spinal Anesthesia (ProCRHYSA randomized Interlaken, Switzerland, 25th-27th June 2014. Poster: “Organ donation process in a Regional dell’articolazione acromio-claveari. trial): Statistical Plan. Hospital - Learning from mistakes”. Tribuna Medica Ticinese 2014;79(11):279-282. Kuala Lumpur, Malaysia, 15th-19th November Cattoni E, Salvatore S, Filippakos F, Leidi L, Gyr T. Interlaken, Switzerland, 29th-31st October 2014. 2014. SGGG Jahreskongress gynécologie suisse 2014. Dessi K, Arigoni M, Candrian C. Oral communication: Is urodynamic evaluation of Conti M, Merlani P. Le fratture mediche costali-intervenire chirurgica- Ceruti S, Peruzzo M, Minotti B, Franceschini D, any value before prolapse surgery? Assemblée annuelle SGI-SSMI 2014. mente? De Vivo S, Lo Piccolo A, De Bianchi D, Anselmi L, Interlaken, Switzerland, 25th-27th June 2014. Poster: Prospective pilot study of the impact of Tribuna Medina Ticinese 2014;79(4):119-122. Saporito A. web-based conferencing on continuous medical 4th International Fluid Academy Days (IFAD) Filippakos F. education in a critical care setting. Wettstein R, Ling B, Harder Y, Schaefer DJ. Meeting. The 3rd international congress on cardiac problems Interlaken, Switzerland, 29th-31st October 2014.

130 Scientific Report 2014 7. Publications in 2014 131 Gigon F, Merlani P, Ricou B. population. Abdominal aortic aneurysm: basics of endovascular Maastricht, Netherlands, 12th-14th May 2014. 27rd Annual Congress of the European Society of Interlaken, Switzerland, 4th-5th December 2014. repair. Intensive Care Medicine (ESICM) 2014. Leipzig, Germany, 28th-29th January 2014. van den Berg JC. Poster: Patients’ and relatives’ knowledge, Gabutti L. EuroPCR 2014. interests and communication about advance care ERA-EDTA Congress. van den Berg JC. Alternative solutions in lower limb revascularisa- planning. Oral communication: Towards a patient-tailored iCON 2014. tion: the classical way; balloon angioplasty, bare Barcelona, Spain, 27th September-1st October strategy. Treatment of in-stent restenosis in the SFA: metal sents. 2014. Amsterdam, Holland, 31st May – 3rd June 2014. results at three years using drug eluting balloons Paris, France, 20th-23rd May 2014. and debulking. Gigon F, Merlani P, Ricou B. Menafoglio A, Di Valentino M, Foglia P, Porretta Phoenix, Arizona, USA, 9th-13th February 2014. van den Berg JC. Assemblée annuelle SGI-SSMI 2014. A, Siragusa P, Romano GA, Pezzoli R, Maggi M, NCVH 2014. Poster: “Patients’ and relatives’ knowledge, Moschovitis G, Gallino A. van den Berg JC. 4F lower limb intervention. interests and communication wishes about Congress of the European Society of Cardiology. iCON 2014. New Orleans, Louisiana, USA, 28th-30th May 2014. advance care planning”. Oral communication: Cardiovascular screening in Endovascular treatment of iliofemoral deep venous Interlaken, Switzerland, 29th-31st October 2014. middle-aged individuals engaged in high intensity thrombosis. van den Berg JC. sport activities: implications, yield and cost-analysis. Phoenix, Arizona, USA, 9th-13th February 2014. MEET 2014. Internal Medicine Barcelona, Spain, 1st-3rd September 2014. Treatment of type II endoleak. van den Berg JC. Nice, France, 7th-11th June 2014. Di Valentino M, Menafoglio A, Porretta P, Foglia Schönholzer C. iCON 2014. P, Siragusa P, Romano GA, Pezzoli R, Maggi M, 46th Annual Meeting of the Swiss Society of Treatment of central venous stenoses related to van den Berg JC. Moschovitis G, Gallino A. Nephrology 2014. dialysis fistula: tips and tricks for endovascular CCVVC 2014. Congress of the Swiss Society of Cardiology. Oral communication: Final Symposium: The really treatment. Which patients and lesions benefit the most with Oral communication: Cardiovascular screening in tough Cases - Who cares and who pays? The Phoenix, Arizona, USA, 9th-13th February 2014. mechanical debulking-when should atherectomy middle-aged individuals engaged in high intensity peritoneal dialysis “quota” patient. be a stand-alone therapy. sport activities: implications, yield and cost-analysis. Interlaken, Switzerland, 4th-5th December 2014. van den Berg JC, Lee J. New York, New York, USA, 10th-11th June 2014. Interlaken, Switzerland, 11th-13th June 2014. SIR 2014. Wein B, Zurek M, Maeder M, Mach F, Moschovitis Bronchial artery embolization case show. van den Berg JC. Di Valentino M, Porretta AP, Foglia P, Siragusa P, G, Beer JH, Senges J, Pfister O. on behalf of EVITA- San Diego, California, USA, 22nd-27th March 2014. CCVVC 2014. Romano GA, Pezzoli R, Maggi M, Moschovitis G, RAID-HF-Registry. DEB technology in SFA lesions and is the future a Gallino A, Menafoglio A. Congress of the Swiss Society of Cardiology. van den Berg JC. combination with atherectomy. Congress of the Swiss Society of Cardiology. Poster: Iron-deficiency and associated factors GEST 2014. New York, New York, USA, 10th-11th June 2014. Poster: Electrocardiogram in young and middle- in patients with congestive heart failure in Case-based discussion: bronchial artery aged athletes: differences in characteristics and Switzerland: Insights from the EVITA-RAID-HF- embolization. van den Berg JC. prevalence of abnormalities. registry. San Francisco, California, USA, 1st-4th May 2014. SGR 2014. Interlaken, Switzerland, 11th-13th June 2014. Interlaken, Switzerland, 11th-13th June 2014. SUPERA clinical results in the SFA-resolving van den Berg JC. challenging situations. Forni Ogna V, Ogna A, Pruijm M, Vuistiner P, Ponte Interventional Radiology GEST 2014. Montreux, Switzerland, 12th-14th June 2014. B, Ackermann D, Gabutti L, Vakilzadeh N, Mohaupt Bronchial artery anatomy and variants. M, Martin P, Guessous I, Pechère-Bertschi A, van den Berg JC. San Francisco, California, USA, 1st-4th May 2014. Walker C, van den Berg JC. Paccaud F, Bochud M, Burnier M. CACVS 2014. AMP 2014. 46th Annual Meeting of the Swiss Society of The V12 RX covered stent as a problem solver for van den Berg JC. Roundtable laser atherectomy workshop. Nephrology. renal and visceral arteries. 18th EVC 2014. Chicago, Illinois, USA, 14th-16th August 2014. Poster: New anthropometry-based-age- and sex- Paris, France, 23rd-25th January 2014. Strategies for optimizing the safety of carotid specific reference values of the urinary 24-h van den Berg JC. stenting in the hyperacute period after onset of van den Berg JC. creatinine excretion based on the adult Swiss LINC 2014. symptoms. AMP 2014.

132 Scientific Report 2014 7. Publications in 2014 133 Laser atherectomy followed with DCB. Peripheral vascular intervention as an outpatient Poster: Evaluation of the SOFIA LEGIONELLA FIA in Swiss Society of Neurology, Annual Meeting. Chicago, Illinois, USA, 14th-16th August 2014. procedure. comparison with the BINAX NOW® LEGIONELLA Teriflunomide in Routine Clinical Practice: Design New York, New York, USA, 17th-20th November urinary antigen card in two National Reference of the TACO Study. van den Berg JC. 2014. Centers. Interlaken, Switzerland, 29th–31st October 2014. AMP 2014. Barcelona, Spain, 10th-13th May 2014. Pathophysiology and mechanism of action of stem van den Berg JC. Gobbi C, Penner I-K, Rohrer S, Schwager K, Stalla- cell therapy. 41st VEITH Symposium. Gaia V, De Respinis S, Monnin V, Arend S, Cellière Bourdillon A. Chicago, Illinois, USA, 14th-16th August 2014. 4 French instrumentation for lower extremity B, Girard V, Tonolla M. Joint Congress of European Neurology 2014. disease treatment as an outpatient: experience in ESCMID Study Group for Legionella Infections, Abstract: Teriflunomide in routine clinical practice: van den Berg JC. >2000 patients over 10 years: how to do it. ESGLI 2014. design of the TACO study. Paris Masterclass in PAD. New York, New York, USA, 18th-22nd November Poster: Rapid identification of Legionella spp. by Istanbul, Turkey, 31st May-3rd June 2014. How to improve the vascular access management? 2014. VITEK® MS. Published in: Eur J Neurol. 21(Suppl. 1):507. Paris, France, 12th September 2014. Barcelona, Spain, 17th-19th September 2014. van den Berg JC. Gobbi C, Riccitelli GC, Calabrese P, Pravatà E, van den Berg JC. VERVE Symposium. Neurology Candrian U, Guttmann CRG, Zecca C. Vascular Forum Milan Interventional Club. Long-term results of laser and DEB for In-Stent American Academy of Neurology. Dissezione aortica acuta e syndrome da malperfu- Restenosis. Agazzi P, Gobbi C. Treatment Satisfaction, Adherence and Behav- sione: tecniche endovascolari. Sydney, Australia, 4th-6th December 2014. 11th European Congress on Epileptology. ioural Assessment in Patients De – escalating Milan, Italy, 15th November 2014. Poster: Long term follow-up (over 10 years) from Natalizumab To Interferon Beta. van den Berg JC. of limbic encephalitis associated with voltage- Philadelphia, Pennsylvania, USA, 26th April - 3rd van den Berg JC. VERVE Symposium. gated potassium channel (VGKC)-complex/LGI1 May 2014. 41st VEITH Symposium. The use of neuro-interventional techniques in antibodies. Published in: Neurol. 2014;82(10 Use of collaterals for access and retrograde wire peripheral intervention. Stockholm, Sweden, 29th June – 3rd July 2014. Supplement):P7.235. passage: how to do it. Sydney, Australia, 4th-6th December 2014. Published in: Epilepsia 2014;55(Suppl. 2):162. doi: New York, New York, USA, 18th-22nd November 10.1111/epi.12675. Maino P. 2014. van den Berg JC. Swiss Pain Congress. VERVE Symposium. Caporro M, Gobbi C, Zecca C. Efficacious dorsal root ganglion stimulation for van den Berg JC. Endovascular treatment of anastomotic break- American Academy of Neurology. painful small fiber neuropathy SSIPM. 41st VEITH Symposium. down and false aneurysm after open surgical re- Life threatening asthmatic crisis after 6 months of Montreux, Switzerland, 21th–22nd November Laser atherectomy and stent graft vs. laser pair. fingolimod treatment. 2014. atherectomy and DEB for ISR: which is best and Sydney, Australia, 4th-6th December 2014. Philadelphia, Pennsylvania, USA, 26th April - 3rd why debulking is essential. May 2014. Maino P, Koetsier E. New York, New York, USA, 18th-22nd November van den Berg JC. Published in: Neurol. 2014;82(10 33rd Annual European Society Regional 2014. 6th International Congress Aortic Surgery and Supplement):P2.225. Anaesthesia (ESRA) Congress. Anesthesia “How to do it”. From surgical plate electrode to dorsal root van den Berg JC. Kidney function and blood pressure response to Caporro M, Gobbi C, Zecca C. ganglion stimulation, 29 year of effective 41st VEITH Symposium. renal artery stenting. ECTRIMS. neuropathic pain relief with neuromodulation: a Endovascular treatment of anastomotic complica- Milan, Italy, 11th-13th December 2014. Poster: Life threatening asthmatic crisis after case report. tions after open surgery – including false aneu- prolonged fingolimod treatment. Seville, Spain, 3rd-6th September 2014. rysms and infections. Laboratory Medicine Boston, Massachusetts, USA, 10th–13th New York, New York, USA, 18th-22nd November September 2014. Maino P, Perez RSGM, Koetsier E. 2014. Freydiere AM, Gervasoni K, Descours G, Published in: Mult Scler. 2014;20(1 suppl):450. World Pain Congress. Vandenesch F, Gérard L, Gaia V, Jarraud S. Accuracy of template-guided refill technique of van den Berg JC. 24th European Congress of Clinical Microbiology Gobbi C, Penner IK, Kamm C, Linnebank M, intrathecal pumps controlled by fluoroscopy. 22nd AIM Symposium. and Infectious Diseases, ECCMID 2014. Baumann A, Henny C, Schwager K, Achtnichts L. Maastricht, The Netherlands, 7th-10th May 2014.

134 Scientific Report 2014 7. Publications in 2014 135 Maino P, Koetsier E, Gobbi C. Pravatà E, Sestieri C, Caulo M, Riccitelli G, Zecca C, University of Berne, Switzerland, 2014. treatment option? 18th Annual Meeting of the North American Cianfoni A, Gobbi C. Interlaken, Switzerland, 29th–31st October 2014. Neuromodulation Society. RSNA 100th Scientific Assembly and Annual Sgroi S, Kaelin-Lang A, Capper-Loup C. Subbaroyan A case study in targeted spinal cord Meeting. 18th MDS International Congress of Parkinson’s Zecca C, Kamm CP, Riccitelli GC, Heldner MR, stimulation (SCS) for small fiber neuropathy: the Abstract SSG12-08: Brain intrinsic Resting-State Disease and Movement Disorders. Caporro M, Staedler S, Gobbi C. clinical utility of the dorsal root ganglion (DRG) as a Functional Connectivity modulation induced by Poster: Role of the opioid receptors on the motor American Academy of Neurology. neuromodulation target. mental effort in Multiple Sclerosis patients with activity and dyskinesia in 6-OHDA parkinsonian Natalizumab in Multiple Sclerosis with Spinal Las Vegas, Nevada, USA, 11th-14th December Fatigue. rats. Involvement. 2014. Chicago, Illinois, USA, 30th November–5th Stockholm, Sweden, 8th-12th June 2014. Philadelphia, Pennsylvania, USA, 26th April -3rd May December 2014. 2014. Maino P, Koetsier E, Gobbi C, Subbaroyan J. Sgroi S, Capper-Loup C, Kaelin-Lang A. Published in: Neurol. 2014;82(10 North American Neuromodulation Society, 18th Riccitelli GC, Rocca MA, Gobbi C, Pagani E, Pravatà SSN Meeting 2014 and Clinical Neurosciences. Supplement):P7.209. Annual Meeting. E, Radaelli M, Martinelli-Boneschi F, Falini A, Comi Spontaneous locomotor activity and L-DOPA A case study in targeted spinal cord stimulation G, Filippi M. induced dyskinesia are not linked in 6-OHDA Zecca C, Kamm CP, Riccitelli G, Heldner MR, (SCS) for small fiber neuropathy: The clinical Joint Congress of European Neurology 2014. parkinsonian rats. Caporro M, Städler C, Gobbi C. utility of the dorsal root ganglion (DRG) as a Abstract: Forceps minor damage and co- Bern, Switzerland, 24th-25th January 2014 Joint Congress of European Neurology 2014. neuromodulation target. occurrence of depression and fatigue in multiple Abstract: Natalizumab in spinal relapsing-remitting Las Vegas, Nevada, 11th-14th December 2014. sclerosis. Sgroi S, Capper-Loup C, Kaelin-Lang A. multiple sclerosis. Istanbul, Turkey, 31st May-3rd June 2014. SFN Neuroscience. Istanbul, Turkey, 31st May-3rd June 2014. Piorkowska K, Antoniello A, Davranche A, Paganetti Published in: Eur J Neurol. 21(Suppl. 1):195. Poster: Different involvement of opioid receptors Published in: Eur J Neurol. 21(Suppl. 1):457. P, Pihlgren M, Adolfsson O, Gafner V, Di Cara DM, in motor control and levodopa induced dyskinesia. Hotzel I, Ayalon G, Pfeifer A, Muhs A. Riccitelli GC, Rocca MA, Pagani E, Preziosa P, Washington DC, USA, 15th-19th November 2014. Zecca C, Pravatà E, Rocca MA, Riccitelli GC, SFN Neuroscience. Martinelli V, Comi, Filippi M, Gobbi C. Cianfoni A, Filippi M, Gobbi C. Development of sensitive assays for specific Quarta Giornata della Ricerca Clinica della Svizzera Valci L, Pravatà E, Kuhlen D, Gobbi C, Dalolio M, ECTRIMS. detection of phosphorylated Tau in human tissue. Italiana. Cianfoni A, Reinert M. Poster: Brain intrinsic resting-state functional Washington DC, USA, 15th-19th November 2014. Abstract: Influence of depression and fatigue on Quarta Giornata della Ricerca Clinica della Svizzera connectivity modulation induced by mental effort in brain damage in multiple sclerosis. Italiana. multiple sclerosis patients with fatigue. Pravatà E, Riccitelli GC, Rocca MA, Pagani E, Bellinzona, Switzerland, 28th March 2014. Abstract: Un caso di encefalocele intra- Boston, Massachusetts, USA, 10th–13th Radaelli M, Martinelli-Boneschi F, Comi C, Filippi M, diploico dell’area motoria primaria: implicazioni September 2014. Gobbi C. Rocca MA, Valsasina P, Pravatà E, Radaelli M, elettrofisiologiche durante la chirurgia. Published in: Mult Scler. 2014;20(1 suppl):120. Quarta Giornata della Ricerca Clinica della Svizzera Martinelli-Boneschi F, Gobbi C, Falini A, Comi G, Bellinzona, Switzerland, 28th March 2014. Italiana. Filippi M. Zecca C, Riccitelli GC, Caporro M, Kamm C, Abstract: Selective WM damage is associated to ECTRIMS. Zanini C, Maino P. Heldmer MR, Pravatà E, Panicari L, Candrian U, the co-occurrence of depression and fatigue in Poster: Depressive symptoms in MS patients are Conference on Communication, Medicine and Gobbi C. multiple sclerosis. associated with abnormal hippocampal resting Ethics. Quarta Giornata della Ricerca Clinica della Svizzera Bellinzona, Switzerland, 28th March 2014. state functional connectivity. P531. Boston, What matters to the patient. Doctors' views on Italiana. Massachusetts, Boston, Massachusetts, USA, how to operationalize the patient perspective in Abstract: Natalizumab in spinal relapsing-remitting Pravatà E, Sestieri C, Caulo M, Riccitelli G, Zecca C, 10th–13th September 2014. the field of chronic pain. multiple sclerosis. Pifferini V, Navarajah N, Cianfoni A, Gobbi C. Published in: Mult Scler. 2014; 20(1 suppl):303. Lugano, Switzerland, 26th-28th June 2014. Bellinzona, Switzerland, 28th March 2014. Quarta Giornata della Ricerca Clinica della Svizzera Italiana. Sgroi S, Capper-Loup C, Kaelin-Lang A. Zecca C, Disanto G, Panicari L, Candrian U, Neuroradiology Abstract: Modulation of brain MRI functional DKF Clinical Day. Staedler C, Gobbi C. connectivity induced by cognitive effort in MS ENK and DYN neuropeptides correlate differently Swiss Society of Neurology, Annual Meeting. Bartalena T, Rinaldi MF, Pravatà E, Cianfoni A, patients with fatigue. with motor activity and levodopa induced dyskinesia Switching from first line immune modulating Bartalena L, Bartalena D. Bellinzona, Switzerland, 28th March 2014. in parkinsonian rats. treatments to glatiramer acetate: A valid 46° Congresso Nazionale SIRM.

136 Scientific Report 2014 7. Publications in 2014 137 Oral communication: RM total-body senza mdc in Cianfoni A, Raz E, Daniele R, Reinert M, Pesce G, Thrombectomie Mécanique à la Phase Aigue des Angiographic Outcomes after 15-year experience. meno di 1 ora con sequenze morfologiche, DWI Bonaldi G. AVC Ischémique par Occlusion en Tandem. Nancy, France, 18th-20th June 2014. ed angio-RM usando l'imaging parallelo: la nostra XXth Symposium Neuroradiologicum. Paris, France, 3rd-5th April 2014. esperienza su soggetti asintomatici. Oral communication: Vertebral Body Stenting Robert T. Firenze, Italy, 22nd-25th May 2014. and Cement Augmentation to Restore Structural Robert T. 2nd World AVM Congress. Stability in Extreme Spinal Osteolysis. Congrès annuel de la Société française de Incidence of External Ventricular Drainage Bartalena T, Rinaldi MF, Pravatà E, Cianfoni A, Istanbul, Turkey, 7th-12th September 2014. Neuroradiologie. Placement on Rebleeding of Ventricular Bartalena L, Bartalena D. Traitement Endovasculaire des AVC Ischémiques Arteriovenous Malformations. 46° Congresso Nazionale SIRM. Massari F, Bonaldi G, Cianfoni A. du Territoire Carotidien. Nancy, France, 18th-20th June 2014. Poster: Black blood imaging del poligono di Willis XXth Symposium Neuroradiologicum. Paris, France, 3rd-5th April 2014. con sequenze SPACE T2. Poster: Interventional Neuroradiology C-Spine Robert T. Firenze, Italy, 22nd-25th May 2014. Procedures. Robert T. 11th SNIS Congress. Istanbul, Turkey, 7th-12th September 2014. Congrès annuel de la Société française de Angiographic Factors Influencing the Success Bartalena T, Rinaldi MF, Pravatà E, Cianfoni A, Neuroradiologie. of Endovascular Treatment of Arteriovenous Rimondi E, Bartalena L. Pravatà E, Sestieri C, Caulo M, Riccitelli G, Zecca C, Poster: Traitement Endovasculaire des AVC Malformations involving the Corpus Callosum. 46° Congresso Nazionale SIRM. Cianfoni A, Gobbi C. Ischémiques du Territoire Carotidien: Efficacité, Colorado Springs, Colorado, USA, 28th-31st July Poster: Imaging isotropico T2-pesato del rachide XXth Symposium Neuroradiologicum. Facteurs Pronostiques Cliniques, Radiologiques et 2014. con sequenze SPACE: applicazioni cliniche e guida Poster: Brain Intrinsic resting-state functional Angiogrqphiques. al post-processing. connectivity modulation induced by mental effort in Paris, France, 3rd-5th April 2014. Robert T. Firenze, Italy, 22nd-25th May 2014. multiple sclerosis patients with fatigue. 11th SNIS Congress. Istanbul, Turkey, 7th-12th September 2014. Robert T. Endovascular Treatment of Posterior Fossa Bartalena T, Rinaldi MF, Pravatà E, Cianfoni A, Congrès annuel de la Société française de Arteriovenous Malformations: Clinical and Rimondi E, Bartalena L. Pravatà E, Sestieri C, Caulo M, Riccitelli G, Zecca C, Neuroradiologie. Angiographic Outcomes after 15-year experience. 46° Congresso Nazionale SIRM. Cianfoni A, Gobbi C. Poster: Le Stent Neuroform EZ dans le Traitement Colorado Springs, Colorado, USA, 28th-31st July Poster: Localizers a confronto: vantaggi delle RSNA 100th Meeting. des Anévrismes Intracrâniens. 2014. sequenze Single Shot Turbo Spin Echo T2 pesate Oral communication: Brain Intrinsic resting-state Paris, France, 3rd-5th April 2014. rispetto alle Spoiled Gradient Echo T1 pesate nella functional connectivity modulation induced by Robert T. pianificazione degli esami RM. mental effort in multiple sclerosis patients with Robert T. 11th SNIS Congress. Firenze, Italy, 22nd-25th May 2014. fatigue. Congrès annuel de la Société française de Incidence of External Ventricular Drainage Chicago, Illinois, USA, 29th November–5th Neuroradiologie. Placement on Rebleeding of Ventricular Bartalena T, Rinaldi MF, Pravatà E, Cianfoni A, December 2014. Stent Retriever Capture: Expérience chez 26 Arteriovenous Malformations. Rimondi E, Bartalena L. Patients ayant présenté un AVC Ischémique. Colorado Springs, Colorado, USA, 28th-31st July 46° Congresso Nazionale SIRM. Neurosurgery Paris, France, 3rd-5th April 2014. 2014. Poster: Valore aggiunto delle sequenze coronali mirate sull'osso sacro nello studio RM del rachide Robert T. Robert T. Robert T. lombare. Congrès annuel de la Société française de 2nd World AVM Congress. 11th SNIS Congress. Firenze, Italy, 22nd-25th May 2014. Neuroradiologie. Angiographic Factors Influencing the Success Single Center Experience with the ADAPT Prise en Charge Multi-Disciplinaire des of Endovascular Treatment of Arteriovenous Technique for Acute Ischemic Stroke. Bartalena T, Rinaldi MF, Pravatà E, Cianfoni A, Malformations Artério-Veineuses de la Fosse Malformations involving the Corpus Callosum. Colorado Springs, Colorado, USA, 28th-31st July Rossi G, Bartalena L. Postérieure. Nancy, France, 18th-20th June 2014. 2014. 46° Congresso Nazionale SIRM. Paris, France, 3rd-5th April 2014. Poster: Utilizzo delle sequenze VIBE T1 con Robert T. Robert T. soppressione del grasso nei casi di spondilolisi Robert T. 2nd World AVM Congress. European association of neurosurgical societies lombare. Congrès annuel de la Société française de Endovascular Treatment of Posterior Fossa annual meeting (EANS 2014). Firenze, Italy, 22nd-25th May 2014. Neuroradiologie. Arteriovenous Malformations: Clinical and Trigeminal Neuralgia due to Arterialization of the

138 Scientific Report 2014 7. Publications in 2014 139 Superior Petrosal Vein in the Context of Dural or complications. L, Kuhlen D, Reinert M. Bellinzona, Switzerland, 28th March 2014. Cerebral Arteriovenous Shunt. Lugano, Switzerland, April 2014. 63° Congresso Nazionale della Società Italiana di Prague, Czech Republic, 12th-17th October 2014. Neurochirurgia (SINCH). Ossola N, Ravetta FL, Bertolotti D, Walther-Veri S, Scarone P, Ruggeri L, Kurzbuch A, Valci L, Bottani Poster: Trattamento delle fratture vertebrali Sanna P. Robert T. L, Kuhlen D, Reinert M. con tecnica percutanea e neuronavigazione con 36th ESPEN Congress. European association of neurosurgical societies Joint Annual Meeting 2014: Swiss Society of Neu- sistema O-Arm. Poster: PP183-MON: Development of a Clinical annual meeting (EANS 2014). rosurgery, Swiss Society of Clinical Neurophysiol- Vicenza, Italy, 25th September 2014. Nutrition Network in the Public Hospitals in Cribriform Plate Dural Arteriovenous Fistulas: ogy, Swiss Society of Neuropaediatrics. southern Switzerland. Technical Difficulties and Complications Avoidance. Poster: Systematic use of intraoperative cone Valsecchi D, Reinert M. Geneva, Switzerland, 6th-9th September 2014. Prague, Czech Republic, 12th-17th October 2014. beam-computed tomography with navigation SGNC (Federal Congress of Neurosurgical Society). (o-arm) in screw positioning: review of a 1-year Poster: Surgical treatment with or without Braunschweig G, Walther-Veri S, Bernard M, Robert T. single center experience. preoperative DSA in a one-year serie of patients Gamondi C, Borasio GD. Society of Vascular and Interventional Neurology, Zurich, Switzerland, 12th June 2014. with cerebral aneurysm. Congresso Nazionale delle Cure Palliative. SVIN 7th annual meeting. Zurich, Switzerland, 13th June 2014. Poster: Questionnements Ethiques Dans Le Cribriform Plate Dural Arteriovenous Fistulas: Scarone P. Cadre D’un Projet De Recherche Sur Les Aspects Technical Difficulties and Complications Avoidance. Simposio Patologia degenerative del rachide Valsecchi D, Scarone P. psychologiques Et Existentiels. Hollywood, Florida, USA, 7th-9th November 2014. lombare. Symposioum on Spine Diseases. Biel, Switzerland, 26th-27th November 2014. Oral communication: Scoliosi lombare degenera- "Pedicle screw fixation with O-arm technology: Robert T. tiva: indicazioni chirurgiche. retrospective analysis of our experience". Pedrazzani C. Société de Neurochirurgie de Langue Française. Lugano, Switzerland, 26th June 2014. Lugano, Switzerland, 26th June 2014. 3° Congresso Nazionale Associazione Italiana Trigeminal Neuralgia due to Arterialization of the Infermieri di Area Oncologica (AIIAO). Superior Petrosal Vein in the Context of Dural or Scarone P. Nursing Medicine Oral communication: Buone pratiche assistenziali: Cerebral Arteriovenous Shunt. 6th SYNS Symposium “Intensive Care/Spine”. Nursing e fatigue. December 2014. Oral communication: Low Back Pain. Bianchi M, Lussu S, Pedrazzani C, Keller N, Ancona, Italy, 29th-31st May 2014. Griesalp, Berner Oberland, Switzerland, 29th-31st Valcarenghi D. Robert T. August 2014. 18th Annual SASRO Meeting 2014. Pedrazzani C. Société de Neurochirurgie de Langue Française. Oral communication: Evidence based practice Assistenza Infermieristica e Ricerca - Congresso Cribriform Plate Dural Arteriovenous Fistulas: Scarone P. (EBP) in Radiotherapy: a Research Project pro- Annuale: “Linee guida e decisioni infermieristiche”. Technical Difficulties and Complications Avoidance. 6th SYNS Symposium “Intensive Care/Spine”. posed by IOSI. L’applicazione delle raccomandazioni nella pratica December 2014. Oral communication: Degenerative spondylolisthe- Lugano, Switzerland, 27th-29th March 2014. quotidiana: l’esperienza degli infermieri dell’Istituto sis. Oncologico della Svizzera Italiana. Rochat-Negro T, Scarone P, Kurzbuch A, Valci L, Griesalp, Berner Oberland, Switzerland, 29th-31st Bianchi M, Lussu S, Pedrazzani C, Valcarenghi D. Torino, Italy, 12th December 2014. Bottani L, Kuhlen D, Reinert M. August 2014. 9a Conferenza Nazionale GIMBE: Evidence e 63° Congresso Nazionale della Società Italiana di Innovazioni per la Sostenibilità della Sanità Pubblica. Pedrazzoli C, Columpsi-Ricci P. Neurochirurgia (SINCH). Scarone P, Botta D, Kurzbuch A, Valci L, Bottani L, La sinergia fra ricerca e prassi nell'utilizzo dei 18th Annual SASRO Meeting 2014 Poster: Coblazione, Artrodesi Percutanea Toraco- Kuhlen D, Reinert M. cateteri venosi centrali a inserimento periferico Oral communication: How do patients perceive Lombare E Cifoplastica Con Stent In Un Caso 63° Congresso Nazionale della Società Italiana di (PICC) all'Istituto Oncologico della Svizzera Italiana. their radiotherapy treatment pathway: what can Di Lesione Metastatica T12: Esecuzione Della Neurochirurgia (SINCH). Bologna, Italy, 14th March 2014. we learn from personal experiences? Procedura In Sala Angiografica Con Equipe Ibrida Oral communication: Decompressione Microchi- Lugano, Switzerland, 27th-29th March 2014. Neurochirurgica-neuroradiologica. rurgica Senza Fusione Nel Trattamento Della Ste- Bianchi M, Pedrazzani C, Valcarenghi D. Vicenza, Italy, 25th September 2014. nosi Del Canale Lombare e della Spondilolistesi Quarta Giornata della Ricerca Clinica della Svizzera Pesenti-Salzmann C, Bianchi M. Degenerativa: In Quali Pazienti? Italiana. 1st Swiss Cancer Congress. Scarone P. Vicenza, Italy, 25th September 2014. Poster: Come cambia l'immagine corporea delle Poster: Pilotprojekt: Sexualberatung und M.O.R.E Symposium (sponsored by MEDACTA). donne dopo l'atelier "Look Good …Feel Better: i -counseling am Istituto Oncologico della Svizzera Oral communication: Minimally invasive surgery Scarone P, Mandelli J, Kurzbuch A, Valci L, Bottani primi risultati. Italiana (IOSI) durch eine in Klinischer Sexologie

140 Scientific Report 2014 7. Publications in 2014 141 ausgebildete Pflegespezialistin. cholangiocarcinoma: a meta-analysis. Bern, Switzerland, 4th September 2014. Gothenburg, Sweden, 18th-22th October 2014. Published in: Eur J Nucl Med Mol Imaging. 2014; Pesenti-Salzmann C, Pellandini J. 41(Suppl 2):S151-S705. Congresso Nazionale delle Cure Palliative. 2013 - Un anno di pallclick. Ayati N, Assadi M, Yarani M, Zakavi SR, Jangjoo A, Biel, Switzerland, 26th-27th November 2014. Memar B, Treglia G, Aliakbarian M, Mehrabibahar M, Sadeghi R. Walther-Veri S, Gamondi C. Annual Meeting of the Society of Nuclear Medicine Congresso Nazionale delle Cure Palliative. and Molecular Imaging. Poster: Palliative sedation: perceptions and Poster: Combined radiotracer and blue dye meth- experiences of the Palliative Care Team in ods for sentinel node mapping in papillary thyroid Southern Switzerland. carcinoma. Biel, Switzerland, 26th-27th November 2014. St. Louis, Missouri, USA, 7th-11th June 2014. Published in: J Nucl Med. 2014;55:1937. Walther-Veri S, Gamondi C. Congresso Nazionale delle Cure Palliative. Ayati N, Ghooshkhanei H, Treglia G, Sabouri G, Ceriani L. Menton, France, 19th-20th September 2014. Oral communication: Indikationen, Prozedere und Davoodi R, Sadeghi R. Quarta Giornata della Ricerca Clinica della Svizzera outcomes der palliative Sedierung: Retrospektive Annual Meeting of the Society of Nuclear Medicine Italiana. Ceriani L, Zucca E, Martelli M, Zinzani PL, Govi S, Studie auf einer palliativstation. and Molecular Imaging. Oral communication: Prognostic value of functional Stelitano C, Vitolo U, Brusamolino E, Cabras G, Biel, Switzerland, 26th-27th November 2014. Poster: Risk stratification and prognosis determi- PET parameters in patients with primary mediasti- Rigacci L, Balzarotti M, Salvi F, Montoto S, Lopez- nation using 18F-FDG PET imaging in endometrial nal diffuse large B cell lymphoma. Guillermo A, Johnson P, Giovanella L. Willems Cavalli Y. cancer patients: a systematic review and meta- Bellinzona, Switzerland, 28th March 2014. Annual Congress of the Swiss Society of Radiology Advocacy infermieristica e medica: la tutela del analysis. and Swiss Society of Nuclear Medicine. paziente e la collaborazione interdisciplinare nella St. Louis, Missouri, USA, 7th-11th June 2014. Ceriani L. Oral communication: Predictive value of the 18FDG cura. Published in: J Nucl Med 2014;55:1573. XVI Symposium of cardiology of regio insubrica. PET-derived quantitative parameters in primary Oral communication: Come prendere una deci- Invited lecture: PET-CT and hybrid imaging in mediastinal diffuse large B-cell lymphoma. sione etica in ambito clinico. Ayati N, Sadeghi R, Ghooshkhanei H, Treglia G, cardiology. Montreux, Switzerland, 12th-14th June 2014. Mendrisio, Switzerland, 2nd April 2014. Sabouri G, Davoodi R. Manno, Switzerland, 2nd April 2014. Published in: Nukleamedizin 2014;53:A111-A126. Annual Congress of the European Association of Willems Cavalli Y. Nuclear Medicine and Molecular Imaging. Ceriani L. Chauvie S, Biggi A, Versari A, Guerra L, Ceriani LEP – Tagung Datenqualität – Dateninterpretation. Poster: Risk stratification and prognosis determi- European Society of Medical Oncology Congress L, Coronado M, Luminari S, Federico M, Zucca E, Oral communication: Anwendung und Nutzen der nation using 18F-FDG PET imaging in endometrial 2014, ESMO–EANM Joint Symposium. Martelli M, Caballero M, Gallamini A. Pflegedaten aus Sicht einer Direktorin Pflege. cancer patients: a systematic review and meta- Invited lecture: Potential and pitfalls in PET-imaging Poster: PET scanner clinical trial qualification for Olten, Switzerland, 13th March 2014. analysis. of lymphoma. worldwide onco-haematological studies. Gothenburg, Sweden, 18th-22th October 2014. Madrid, Spain, 26th-30th September 2014. Menton, France, 19th-20th September 2014. Nuclear Medicine Published in: Eur J Nucl Med Mol Imaging. 2014;41(Suppl 2):S151-S705. Ceriani L, Barrington S, Biggi A, Malkowski B, Giovanella L. Annunziata S, Pizzuto D, Caldarella C, Sadeghi R, Metser U, Versari A, Zucca E, Chauvie S. Thyroid Carcinoma Biomarkers Forum. Giovanella L, Treglia G, Giordano A. Ceriani L. 5th International Workshop on PET in Lymphoma. Invited lecture: Circulating markers of thyroid Annual Congress of the European Association of LyFE Forum for Excellence “What’s new in lymphoid Poster: Impact of specific training in the tumors: new insight and clinical impact. Nuclear Medicine and Molecular Imaging. neoplasias?” performance of the central review panel in the Wuhan, China, 25th April 2014. Poster: Diagnostic accuracy of Fluorine-18-Fluoro- Invited lecture: PET-imaging: when can it be used to ongoing IELSG37 study of primary mediastinal deoxyglucose positron emission tomography in the direct lymphoma treatment? lymphoma. Giovanella L. evaluation of the primary tumor in patients with Bellinzona, Switzerland, 14th-16th February 2014.

142 Scientific Report 2014 7. Publications in 2014 143 Annual Congress of the Swiss Society of Radiology and treatment of most frequent tumours at the Poster flash presentation: Discordance rate be- Vienna, Austria, 25th-27th September 2014. and Swiss Society of Nuclear Medicine. Oncology Institute of Southern Switzerland”. tween radiolabelled choline PET/CT and bone scin- Invited lecture: Treatment and Follow-up of Differ- Oral communication: Role of PET in the follow-up of tigraphy in detecting bone metastases of prostate Treglia G. entiated Thyroid Carcinoma: an Update. head & neck tumours. cancer. Workshop “Revised guidelines on diagnosis Montreux, Switzerland, 12th-14th June 2014 Oral communication: Presentation and activities of Bellinzona, Switzerland, 28th March 2014. and treatment of most frequent tumours at the EOC Competence Centre for Thyroid Diseases. Oncology Institute of Southern Switzerland. Giovanella L. Locarno, Switzerland, 29th November 2014. Treglia G. Oral communication: New PET indications. Thyroid Cancer Summer School. Workshop “Focus on: lung neuroendocrine Locarno, Switzerland, 29th November 2014. Invited lecture: High-sensitive thyroglobulin. Paone G, Treglia G, Ruberto T, Ceriani L, Giovanella tumours”. University of Marburg, Germany, August 2014. L. Invited lecture: Metabolic and radioreceptor Treglia G, Sadeghi R, Annunziata S, Caldarella C, Quarta Giornata della Ricerca Clinica della Svizzera imaging. Bertagna F, Giovanella L. Giovanella L. Italiana. Reggio Emilia, Italy, 16th May 2014. Annual Congress of the European Association of 38th European Thyroid Association Meeting- Poster: Clinical impact of 18F-FDG PET/CT in the Nuclear Medicine and Molecular Imaging. Cancer Research Network Symposium. management of patients with cancer of unknown Treglia G, Sadeghi R, Caldarella C, Ceriani L, Poster: Diagnostic accuracy of F18-FDG PET in the Invited lecture: Discovering DTC recurrence by origin. Giovanella L. post-chemotherapy management of patients with conventional versus highly sensitive Tg assays. Bellinzona, Switzerland, 28th March 2014. Annual Congress of the Swiss Society of Radiology seminoma: a meta-analysis. Santiago de Compostela, Spain, 6th-10th September and Swiss Society of Nuclear Medicine. Gothenburg, Sweden, 18th-22th October 2014. 2014 Paone G, Treglia G, Ruberto T, Ceriani L, Giovanella Oral communication: Detection rate of Tc- Published in: Eur J Nucl Med Mol Imaging. L. 99m-MIBI SPECT/CT in patients with primary 2014;41(Suppl 2):S151-S705. Giovanella L. Annual Congress of the Swiss Society of Radiology hyperparathyroidism: a meta-analysis. Symposium “New aspects in diagnosis, therapy and Swiss Society of Nuclear Medicine. Montreux, Switzerland, 12th-14th June 2014. Treglia G, Zucca E, Sadeghi R, Cavalli F, Giovanella and follow-up of differentiated thyroid carcinoma”. Oral communication: Can we use the PET/CT Published in: Nukleamedizin 2014;53:A111-A126. L, Ceriani L. Invited lecture: Recombinant TSH: clinical trials imaging for local staging in advanced glottic 5th International Workshop on PET in Lymphoma. and indication. cancer? Clinical impact and comparison with Treglia G, Sadeghi R, Annunziata S, Ceriani L, Poster: Detection rate of F18-FDG PET in patients Brescia, Italy, 15th-16th September 2014. conventional imaging. Giovanella L. with marginal zone lymphoma of the MALT type: a Montreux, Switzerland, 12th-14th June 2014. Annual Congress of the Swiss Society of Radiology meta-analysis. Giovanella L. Published in: Nukleamedizin 2014;53:A111-A126. and Swiss Society of Nuclear Medicine. Menton, France, 19th-20thSeptember 2014. Symposium “From thyroid nodular disease to Poster: 18F-FDG-PET or PET/CT in the differential differentiated thyroid cancer: clinical management Piccardo A, Massollo M, Puntoni M, Foppiani L, diagnosis between malignant and benign pleural Oncology and new approaches”. Naseri M, Treglia G, Arlandini A, Catrambone U, lesions: diagnostic performance meta-analyses in Invited lecture: Serum, sonographic and metabolic Bandelloni R, Cabria M, Giovanella L, Villavecchia G. patients with or without cancer history. Bernhard J, Luo W, Ribi K, Colleoni M, Burstein biomarkers in the differential diagnosis of thyroid Annual Congress of the European Association of Montreux, Switzerland, 12th-14th June 2014. HJ, Tondini C, Pinotti G, Spazzapan S, Ruhstaller T, nodules. Nuclear Medicine and Molecular Imaging. Published in: Nukleamedizin 2014;53:A111-A126. Puglisi F, Pavesi L, Parmar V, Regan MM, Pagani Messina, Italy, 18th December 2014. Oral communication: Role of 18F-FDG PET/CT in O, Fleming GF, Francis PA, Coates AS, Gelber RD, Presurgical Characterization of Thyroid Nodules Treglia G. Goldhirsch A, Walley B, for the SOFT and TEXT Massara R, Brizi MG, Treglia G, Farchione A, Lanza with Indeterminate Fine Needle Aspiration Workshop “The multidisciplinary approach for lung investigators and International Breast Cancer F, Bonomo L. Cytology. Comparison with neck ultrasonography tumours”. Study Group. XXXXVI Congress of the Italian Society of Medical and 99mTc MIBI scintigraphy. Oral communication: Role of PET in lung tumours. Patient-reported endocrine symptoms, sexual Radiology. Gothenburg, Sweden, 18th-22th October 2014. Mendrisio, Switzerland, 18th June 2014. functioning and quality of life (QoL) in the IBCSG Poster: Functional Imaging in pancreatic neuroen- Published in: Eur J Nucl Med Mol Imaging. TEXT and SOFT trials: adjuvant treatment docrine tumours. 2014;41(Suppl 2):S151-S705. Treglia G. with exemestane (E) plus ovarian function Firenze, Italy, 22th-25th May 2014. 14th International workshop on multiple endocrine suppression (OFS) versus tamoxifen (T) plus OFS Treglia G. neoplasia and other rare endocrine tumors. in premenopausal women with hormone receptor- Paone G. Quarta Giornata della Ricerca Clinica della Svizzera Invited lecture: Medullar thyroid carcinoma: positive (HR+) breast cancer (BC). Workshop “Revised guidelines on diagnosis Italiana. functional imaging. 2014 Annual Meeting of the American Society of

144 Scientific Report 2014 7. Publications in 2014 145 Clinical Oncology (ASCO). the Salivary Gland Is Associated with Improved Symposium (SABCS). 2014. Chicago, Illinois, USA, 30th May- 3rd June 2014; Prognosis When Arising in a Background of Advanced HER2 positive breast cancer treated Sjögren’s Disease and May Not Benefit from Local with trastuzumab: is combination with chemo Vitolo U, Chiappella A, Martelli M, Ferreri AJ, Baldi Bernasconi E, Tarantelli C, Gaudio E, Kwee I, Rinaldi Therapy – IELSG 41. therapy always needed? Randomized Phase III trial I, Balzarotti M, Bottelli C, Conconi A, De Masi P, A, Cascione L, Stathis A, Riveiro ME, Zucca E, San Francisco, California, USA, 6th-9th December SAKK 22/99. Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Bertoni F. 2014. San Antonio, Texas, USA, 9th-13th December 2014. Bairey O, Orsucci L, Pavone V, Ricardi U, Storti S, American Society of Hematology, 56th Annual Gospodarowicz MK, Cavalli F, Sarris AH1, Zucca E. Meeting. Johansson H, Gray KP, Pagani O, Regan MM, Stathis A, Freedman AS, Flinn IW, Maddocks KJ, European Hematology Association 19th Congress. Poster: The BET-Bromodomain Inhibitor OTX015 Viale G, Aristarco V, Debora M, Puccio A, Roux S, Weitman S, Berdeja JG, Mejia AV, Zucca E, Green Poster: Rituximab-Chop Plus Intrathecal Metho- Is Active As a Single Agent and in Combination Maibach R, Colleoni M, Rabaglio-Poretti M, Coates R, Romanelli A, Zildjian SH, Ruiz-Soto R, Palomba L. trexate and Contralateral Testis Irradiation in Un- with Other Targeted Drugs in Preclinical Models of AS, Gel-ber RD, Goldhirsch A, Kammler R, Bonanni American Society of Hematology, 56th Annual treated Primary Testicular Diffuse Large B-Cell Mantle Cell Lymphoma. B, Walley BA. Meeting. Lymphoma: Long-Term Results of the IELSG-10 San Francisco, California, USA, 6th-9th December 37th Annual San Antonio Breast Cancer Poster: A Phase I Study of IMGN529, an Antibody- Trial. 2014. Symposium (SABCS). Drug Conjugate (ADC) Targeting CD37, in Adult Milan, Italy, 12th-15th June 2015. CYP19A1 and ESR1 polymorphisms and selected Patients with Relapsed or Refractory B-Cell Non- Cascione L, Gaudio E, Bernasconi E, Tarantelli C, early-onset side effects during combined endo-crine Hodgkin’s Lymphoma (NHL). Zucca E, Martelli M, Zinzani PL, Ferreri AJM, Rinaldi A, Testoni M, Bomben R, Gattei V, Kwee I, therapy in the IBCSG TEXT trial for premenopausal San Francisco, California, USA, 6th-9th December Russo E, Montoto S, Lopez Guillermo A, Davies AJ, Stathis A, Riveiro ME, Zucca E, Bertoni F. women with hor-mone receptor-positive (HR+) 2014. Johnson PWM, Giovanella L, Cavalli F, Ceriani L. American Society of Hematology, 56th Annual early breast cancer. European Hematology Association, 19th Congress. Meeting. San Antonio, Texas, USA, 9th-13th December 2014. Tarantelli C, Gaudio E, Kwee I, Rinaldi A, Stifanelli Oral communication: Prognostic Models for Poster: BET Bromodomain Inhibitor OTX015 M, Bernasconi E, Barassi, C Hillmann P, Stathis Primary Mediastinal B-Cell Lymphoma Derived Affects the Expression of Micrornas Involved in the Kimby E, Martinelli G, Ostenstad B, Mey U, Rauch A, Carrassa L, Broggini M, Stussi G, Fabbro D, from 18-FDG PET/CT Quantitative Parameters in Pathogenesis of Diffuse Large B-Cell Lymphoma. D, Wahlin BE, Hitz F, Hernberg M, Johansson AS, Hebeisen P, Betts F, Wicki A, Zucca E, Cmiljanovic the IELSG-26 Study. San Francisco, California, USA, 6th-9th December de Nully Brown P, Hagberg H, Ferreri AJM, Lohri V, Bertoni F. Milan, Italy, 12th-15th June 2015. 2014. A, Novak U, Zander T, Bersvendsen H, Bargetzi American Society of Hematology, 56th Annual M, Mingrone W, Krasniqi F, Dirnhofer S, Hawle H, Meeting. Paediatric surgery Fleury I, Chevret S, Pfreundschuh M, Salles G, Berardi S, Demmel S, Rondeau S, Zucca E. Poster: The Novel PI3K/mTOR Dual Inhibitor Coiffier B, van Oers MHJ, Gisselbrecht C, Zucca E, American Society of Hematology, 56th Annual PQR309 in Pre-Clinical Lymphoma Models: De Rosa V, Canavese F, Andreacchio A, Cravino M, Herold M, Ghielmini M, Thieblemont C Meeting. Demonstration of Anti-Tumor Activity As Single Marengo L, Mendoza M. American Society of Hematology, 56th Annual Oral communication: Rituximab Plus Lenalidomide Agent and in Combination and Identification of 74ème Congrès annuel de swiss orthopaedics Meeting. Improves the Complete Remission Rate in Com- Gene Expression Signatures Associated with (SSOT) 2014. Poster: No Increased Risk of Secondary parison with Rituximab Monotherapy in Untreated Response. Outcome of displaced distal tibial metaphyseal Neoplasms in Patients Treated with Rituximab for Follicular Lymphoma Patients in Need of Therapy. San Francisco, California, USA, 6th-9th December fractures in children between six and fifteen years Non-Hodgkin’s Lymphoma : A Meta-Analysis of 9 Primary Endpoint Analysis of the Randomized 2014. of age treated by elastic stable intramedullary Trials. Phase-2 Trial SAKK 35/10. nails. San Francisco, California, USA, 6th-9th December San Francisco, California, USA, 6th-9th December Thieblemont C, Stathis A, Inghirami G, Karlin L, St. Gallen, Switzerland, 25th-27th June 2014. 2014. 2014. Morschhauser F, Gleeson M, Broussais F, Amorim S, Salles G, Facon T, Cunningham D, Vey N, Bourdel Mendoza-Sagaon M. Jackson A, Michael Mian M, Kalpadakis C, Pangalis Pagani O, Klingbiel D, Ruhstaller T, Nolè F, F, Herait P, Zucca E. XXIIème Symposium de l’ASRCC (Association G, Stathis A, Porro E, McPhail E, Habermann T, Eppenberger S, Oehlschlegel C, Jürg Bernhard, American Society of Hematology, 56th Annual Suisse Romande de Chirurgie Coelioscopique). Ristow K, Cavalli F, Nowakowski G, Zucca E. Brauchli P, Hess D, Mamot C, Munzone E, Meeting. Forum du Crédit Suisse. American Society of Hematology, 56th Annual Pestalozzi B, Rabaglio M, Ribi K, Rochlitz C, Poster: A Phase 1 Study of the BET-Bromodomain Robotic Surgery in Children. Meeting. Rothgiesser K, Thürlimann B, von Moos R, Zaman Inhibitor OTX015 in Patients with Non-Leukemic Geneva, Switzerland, 27th -28th March 2014. Poster: Extranodal Marginal Zone Lymphoma of K and Goldhirsch A. Hematologic Malignancies. Mucosa-Associated Lymphoid Tissue (MALT) of 37th Annual San Antonio Breast Cancer San Francisco, California, USA, 6th-9th December Mendoza-Sagaon M, Hamitaga F, Voumard NM.

146 Scientific Report 2014 7. Publications in 2014 147 23rd annual congress of the International Pediatric Nationaler Palliative Care Kongress. iche in oncologia. Oral communication: RapidArc (RA) technique vs Endosurgery Group (IPEG). Poster: Questionnements éthiques dans le Invited lecture: Conseguenze a lungo termine della Intensity-Modulated adjuvant Single-Incision laparoscopic inguinal hernia repair cadre d’un projet de recherche sur les aspects radioterapia sulla funzione sessuale nel paziente radiotherapy (IMRT) in breast cancer: acute in girls. psychologiques et existentiels. con carcinoma prostatico. toxicities comparison. Edinburgh, Scotland, 22nd-26th July 2014. Bienne, Switzerland, 26th-27th October 2014. Rozzano, Italy, 8th November 2014. Lugano, Switzerland, 27th-29th March 2014.

Mendoza-Sagaon M, Hamitaga F, Voumard NM. Ossola N, Ravetta F, Bertolotti D, Walther Veri S, Belkacemi Y, Kaidar-Person O, Poortmans P, M. Stelmes JJ, Azinwi NC. 4th annual congress of the European Society of Sanna P, on behalf of the Commissione Nutrizione Ozsahin M, Valli MC, Russell N, Kunkler I, Hermans 9ième Journée Romande de Radio-Oncologie. Pediatric Endoscopic Surgeons (ESPES). EOC. J, Kuten A, van Tienhoven G, Westenberg H. Oral communication: Analyse des facteurs Single-Incision laparoscopic inguinal hernia repair The European Society for Clinical Nutrition and 56th annual ASTRO meeting. prognostiques et mortalité à 30 jours après in girls. Metabolism (ESPEN); 2014 Annual Congress. Abstract: Patterns of practice of nodal radiotherapy Radiothérapie palliative. Expérience de notre Bratislava, Slovakia, 1st-3rd October 2014. Poster: Development of a Clinical Nutrition Network in breast cancer: Results of the EORTC “Nora” centre sur une série de 140 patients. in the Public Hospitals in Southern Switzerland. survey. Lausanne, Switzerland, 2nd October 2014. Palliative Care Geneva, Switzerland, 6th-9th September 2014. San Francisco, California, USA, 14th-17th Septem- ber 2014. Stelmes JJ, Richetti A, Valli MC, Pesce GF, Azinwi Bardelli D, Del Torso M, Zocchi-Aeberli M, Bianchi Pesenti-Salzmann C, Pellandini J. NC, Pittoni P, Fanti P, Martucci F. 18th Annual M, Neuenschwander H. Nationaler Palliative Care Kongress. Leva S, Pittoni P, Pesce GF, Martucci F, Azinwi SASRO meeting. XXI Congresso Nazionale SICP. Poster: 2013 - Un anno di Pallclick. NC, Fanti P, Stelmes JJ, Rottoli G, Tettamanti M, Poster: The role of planned PEG in patients with Oral communication: CALL ME: uno strumento Bienne, Switzerland, 26th-27th October 2014. Richetti A, Valli MC. head and neck cancer treated with radiotherapy. per identificare precocemente il paziente di cure 18th Annual SASRO meeting. Lugano, Switzerland, 27th-29th March 2014. palliative. Walther Veri S. Oral communication: Assessment of reproducibility Arezzo, Italy, 9th-12th October 2014. Nationaler Palliative Care Kongress. and stability during deep inspiration breath hold Struikmans H, Poortmans P, Kirkove C, Budach Oral communication: Indikationen, Prozedere und (DIBH) radiotherapy (RT) for left-sided breast V, Maingon P, Valli MC, Collette S, Fourquet A, Bardelli D, Luraghi R, Hefti S. Neuenschwander H. outcomes der palliativen Sedierung: Retrospektive cancer patients and evaluation of geometrical Bartelink H, Van den Bogaert W. XXI Congresso Nazionale SICP. Studie auf einer Palliativstation. heart displacements. 9th European Breast Cancer Conference (EBCC-9). Poster: Integrazione dei servizi specialistici in Cure Bienne, Switzerland, 26th-27th October 2014. Lugano, Switzerland, 27th-29th March 2014. Abstract: “The benefit of regional irradiation in Palliative intra ed extra ospedalieri in Ticino. stage I-III breast cancer: 10 years results of the Arezzo, Italy, 9th-12th October 2014. Walther Veri S. Martucci F, Stelmes JJ, Valli MC, Pesce GF, Pittoni EORTC ROG and BCG phase III trial 22922/10925. Giornata GIOTI su: Farmaci orali di nuova P, Fanti P, Azinwi NC, Richetti A. 18th Annual Glasgow, Great Britain, 19th-21st March 2014. Fusi-Schmidhauser T, Bardelli D, Pellandini J, generazione in oncologia. SASRO meeting. Sanna P, e gruppo redazione Pallclick. Oral communication: Trattamento del dolore Oral communication: Use of Image Guided Valli MC. XXI Congresso Nazionale SICP. cronico e ruolo infermieristico. Radiotherapy (IGRT) and 4D CT in Stereotactic 18th Annual SASRO meeting. Oral communication: PALLCLICK: manuale Cadempino, Switzerland, 20th November 2014. Body Radiotherapy (SBRT) of lung cancer: IOSI Oral communication: The impact of 18FDG-PET/ elettronico di Cure Palliative. experience. CT in modifying the treatment strategy in locally Arezzo, Italy, 9th-12th October 2014. Walther Veri S, Gamondi C. Lugano, Switzerland, 27th-29th March 2014. advanced or high risk breast cancer patients in Nationaler Palliative Care Kongress. XVIII. Gamondi C, Borasio G. Poster: Palliative Sedation: Perceptions and Pesce GF. Lugano, Switzerland, 27th-29th March 2014. Workshop. 20th International Congress on Experiences of the Palliative Care Team in Neuro-oncology meeting. Palliative Care. Southern Switzerland. Invited lecture: Role of the reirradiation: is it a place Valli MC. Assisted suicide: the role of families and health Bienne, Switzerland, 26th-27th October 2014. for radiosurgery? JSASS Congress 2014. care institutions. Naples, Italy, 3rd-4th July 2014. Oral communication: Accelerated Partial Breast Montreal (CA). September 2014. Radiation Oncology Irradiation: the Ticino experience. Lugano, Pittoni P, Pesce GF, Martucci F, Azinwi NC, Fanti Switzerland, 11th-12th September 2014. Gamondi C, Borasio GD, Bernard M, Braunschweig Azinwi NC, Pesce GP. P, Stelmes JJ, Richetti A, Valli MC. 18th Annual G. Il sabato dell’andrologia, Problematiche androlog- SASRO meeting. Valli MC, Pesce G, Martucci F, Azinwi NC, Pittoni P,

148 Scientific Report 2014 7. Publications in 2014 149 Fanti P, Stelmes JJ, Leva S, Richetti A. Agten CA, Del Grande F, Fucentese SF, Blatter S, gie in den Karotiden und Femoralarterien mit Hilfe Frankfurt, Germany, 24th-27th May 2014. 18th annual SASRO meeting. Pfirrmann CW, Sutter R. der nicht-invasiven MRT-Plaquebildgebung. Böttcher J, Clerici N, Castelanelli S, Candrian C. Abstract: How to check and eventually decrease ESSR 2014. Hamburg, Germany, 28th-31st May 2014. Le 101e Congrès annuel de la Société Suisse de prescription, simulation, treatment study and Oral communication: Unicompartmental Knee Chirurgie. treatment delivery errors in a paperless RT Arthroplasty MRI: Impact of Slice-Encoding for Porretta AP, Alerci M, Gallino A, von Segesser Poster: Patient satisfaction after anterior cruciate department. Metal Artifact Correction MRI on Image Quality, LK, Inglese L, Guerra A, Bogen M, Di Valentino M, ligament reconstruction in outpatient surgery. Lugano, Switzerland, 27th-29th March 2014. Findings, and Therapy Decision. Wyttenbach R. Bern, Switzerland, 21st-23rd May 2014. Riga, Latvia, 26th-28th June 2014. SGR-SSR Congress. Wick W, Gorlia T, Van Den Bent MJ, Vecht CJ, Telementoring: An effective strategy to support Böttcher J, Clerici N, Castelanelli S, Candrian C. Steuve J, Brandes AA, Platten M, Kosch MA, Hegi Agten CA, Del Grande F, Fucentese SF, Blatter S, technical skill acquisition in endovascular aneurysm Le 101e Congrès annuel de la Société Suisse de ME, Lhermitte B, Golfinopoulos V, Campone M, Pfirrmann CW, Sutter R. repair. Chirurgie. Frenel JS, Taphoorn MJB, Pesce GA, Roth P. RSNA 2014 Montreux, Switzerland, 12th-14th June 2014. Oral communication: Patient satisfaction after ASCO 2014. Oral communication: Unicompartmental Knee shoulder arthroscopy in outpatient surgery. Abstract: Radiation therapy and concurrent plus Arthroplasty MRI: Impact of Slice-Encoding for Regini F, Mazzoni LN, Busoni S, Matteuzzi B, Santini Bern, Switzerland, 21st-23rd May 2014. adjuvant temsirolimus (CCI-779) versus chemo Metal Artifact Correction MRI on Image Quality, PQR, Wyttenbach R. irradiation with temozolomide in newly diagnosed Findings, and Therapy Decision. Congresso SIRM 2014. Candrian C. glioblastoma without methylation of the MGMT Chicago, Illinois, USA, 30th November-5th Valutazione multi-parametrica della perfusione The Eastern Orthopaedic Association’s Annual gene promoter. December 2014. epatica con l’utilizzo di sequenze RM in diffusione Meeting. Chicago, USA, 29th May-3rd June 2014. (DWI): correlazione con la misurazione del flusso Oral communication: Subscapularis Fatty Infiltra- Published in: J Clin Oncol. 2014;32:5s. Ahlawat S, Dreizin D, Del Grande F, Fayad LM. portale tramite acquisizioni Phase Contrast (PC). tion And Clinical Evaluation After Tenotomy In Total Electronic exhibit ARRS 2014. Florence, Italy, 22nd-25th May 2014. Shoulder Arthroplasty. Yordanov K, Valli MC, Pittoni P, Martucci F, Pesce Gradient Echo In-phase and Opposed-phase Amelia Island, Florida, USA, 22nd-25th October GF, Azinwi NC, Stelmes JJ, Fanti P, Richetti A. Chemical Shift Imaging: Current concepts for Schneebeli A, Cescon C, Del Grande F, Vincenzo G, 2014. 7th European Multidisciplinary Colorectal Cancer Evaluating the Bone Marrow. Biordi F, Barbero M. Congress (EMCCC). San Diego, California, USA, 4th-9th May 2014. ISEK 2014. Christoforidis D. Poster: Acute gastrointestinal and genitourinary Real-time elastography using an external reference Clinical challenges in IBD management: from toxicity in rectal cancer patients treated with Del Grande F, Fayad LM. material: preliminary results of achilles tendon literature data to clinical practice. preoperative Intensity Modulated Radiation Electronic exhibit RSNA 2014. elasticity pattern. Oral communication: Challenging cases in Crohn’s Therapy- Rapid Arc (IMRT-Rapid Arc). Bone Marrow Signal Changes on MRI: What Is Roma, Italy, 15th-18th July 2014. disease. Amsterdam, The Netherlands, 23rd-25th November Normal? Humanitas Research Hospital, Rozzano-Milan, 2014. Chicago, Illinois, USA, 30th November-5th Schneebeli A, Cescon C, Del Grande F, Vincenzo G, Italy, 9th June 2014. December 2014. Biordi F, Barbero M. Radiology ISEK 2014. Christoforidis D. Helck A, Bianda N, Canton G, Yuan C, Reiser MF, Test-retest reliability of real-time elastography 35. Tagung der Schweizerischen Arbeitsgruppe Abay S, Silver M, Wang KC, Del Grande F, Carrino Gallino A, Wyttenbach R, Saam T. using an external reference material: preliminary für Koloproktologie. JA. European Congress of Radiology (ECR 2014). results. Oral communication: Minimal-invasive Therapie- Electronic exhibit RSNA 2014. Intra-individual comparison of carotid and femoral Roma, Italy, 15th-18th July 2014. konzepte für Analfisteln. Illustration and MRI Atlas of the Ankle: 3D-MR atherosclerotic plaque features with in vivo MR Bern, Switzerland, 18th January 2014. Imaging at 3-Tesla of the Ligaments, Tendons, and plaque imaging (SS 1815), B-1039. Surgery Cartilage of the Ankle and Hindfoot, Accompanied Vienna, Austria, 6th-10th March 2014. Christoforidis D. by Detailed Original Medical Illustration of the Böttcher J, Candrian C. 12. Dreiländertreffen der Arbeitsgemeinschaften Deltoid Ligamentous Complex. Helck A, Bianda N, Canton G, Yuan C, Reiser M, The 15th European Congress of Trauma & Emer- für Minimalinvasive Chirurgie. Chicago, Illinois, USA, 30th November-5th December Gallino A, Wyttenbach R, Saam T. gency Surgery & 2nd World Trauma Congress. Oral communication: Kolonkarzinom: Probleme 2014. 95. Deutscher Röntgenkongress. Poster: Patient satisfaction after shoulder arthros- rund um die linke Flexur. Intra-individueller Vergleich der Plaquemorpholo- copy in outpatient surgery. Bern, Switzerland, 31st January-1st February

150 Scientific Report 2014 7. Publications in 2014 151 2014. Christoforidis D. Bern, Switzerland, 21st-23rd May 2014. firmed male. Christoforidis D. Riunione dello IOSI per la discussione delle linee Exner GU, Candrian C. Galtür, Austria, January 2014. Le 101e Congrès annuel de la Société Suisse de guida in oncologia “Blaubuch”. 74. Jahreskongress der Swiss orthopaedics Chirurgie. Oral communication: Chirurgia mini invasiva (SGOT) 2014. Harder Y, Allan A, Finck T, Müller DF, Eder M, Oral communication: Colectomie droite laparo- transanale per il carcinoma del retto. Poster: Treatment of aneurysmal bone cysts with Kovacs L, Schantz JT, Machens HG. 131. Kongress scopique avec "Complete Mesorectal Excision": Locarno, Switzerland, 29th November 2014. alcoholoc preparations. der Deutschen Gesellschaft für Chirurgie (DGCH). Technique opératoire et revue de la littérature. St. Gallen, Switzerland, 25th-26th June 2014. Oral communication: Resorptionsverhalten von Bern, Switzerland, 21st-23rd May 2014. Celio D, Regazzoni S, Rosso R, Giovannacci L. Eigenfett in der rekonstruierten Brust unter Le 101e Congrès annuel de la Société Suisse de Fusetti C, Brunetti S, Lucchina S, Prevital T, Berücksichtigung von adjuvanter Bestrahlung und Christoforidis D. Chirurgie. Saporito A. Rauchen. Le 101e Congrès annuel de la Société Suisse de Oral communication: Hypofibrinogenemia: an SGH-SSCM. Berlin, Germany, 25th-28th March 2014. Chirurgie. atypical cause of acute ischemia of the upper limb. Calm or not calm? Impact of an informational video Oral communication: SALTC Masterclass in colo- Bern, Switzerland, 21st-23rd May 2014. on patient's anxiety and satisfaction. A prospective Harder Y. rectal laparoscopic surgery: update. study. Kolloquim: Rekonstruktion durch Eigengewe- Bern, Switzerland, 21st-23rd May 2014. Cristaudi A, Galetti K, Rosso R, Christoforidis D. Thun, Switzerland, 13th-14th November 2014. befetttransfer; Klinik für Hand-, Plastische, Rekon- Le 101e Congrès annuel de la Société Suisse de struktive und Verbrennungschirurgie, BG-Klinikum Christoforidis D. Chirurgie. Gächter B. Tübingen. Simposio Primaverile di chirurgia – La diverticolite Poster: Reduced port colectomy through the stoma Gemeinsamer Kongress der Schweizerischen Oral communication: Resorptionsverhalten nach semplice e la pancreatite. site following short term loop transversostomy for Gesellschaft für Wundbehandlung. Eigenfetttransfer in der Brustchirurgie. Oral communication: Gestione ambulatoriale della occlusive sigmoid cancer. Oral communication: Patientenzentrierte Wundbe- Tübingen, Germany, March 2014. diverticolite semplice: collaborazione fra ospedale Bern, Switzerland, 21st-23rd May 2014. handlung. e medici curanti. Biel, Switzerland, 25th September 2014. Harder Y. Lugano, Switzerland, 12th June 2014. Cristaudi A, Galetti K, Rosso R, Christoforidis D. Autologous Fat Grafting Symposium (SGPRAEC). 9th Scientific and Annual Meeting of the European Gächter B. Oral communication: Fat grafting to the recon- Christoforidis D. Society of Coloproctology. 12° Corso di aggiornamento per il medico di base. structed breast: Course of fat reabsorpation and Schweizerische Gesellschaft für Allgemein Poster: Reduced port colectomy through the stoma Oral communication: Cura delle ulcere. morbidity. Chirurgie und Traumatologie (SGATC) 18. Bieler site following short term loop transversostomy for Giubiasco, Switzerland, 10th October 2014. Basel, Switzerland, 9th May 2014. Fortbildungstage. occlusive sigmoid cancer. Oral communication: Sigmoidectomie par laparos- Barcelona, Spain, 24th- 26th September 2014. Gächter B. Harder Y, Allan AA, Müller D, Eder M, Kovacs L, copie avec extraction trans-rectale. 2. Treffen Fachgruppe Biochiurgie “Geburtsort Schantz JT, Machens HG. Biel, Switzerland, 4th-5th September 2014. Dessì K, Minervini F, Mezzetto L, Rosso R, Lucy”. 50. Kongress der Schweizerischen Gesellschaft Giovannacci L. Oral communication: Problemfall Maden. für Plastische, Rekonstruktive und Ästhetische Christoforidis D. Le 101e Congrès annuel de la Société Suisse de Grossdietwil, Switzerland, 2nd December 2014. Chirurgie (SGPRAC) & 2. Jahrestagung der Jahreskongress Schweizerische Gesellschaft für Chirurgie. Gesellschaft für Ästhetische Chirurgie (SGÄC). Viszeralchirurgie” (SGVC). Oral communication: Hemodialysis vascular ac- Harder Y. Oral communication: Surgical refinement of the Oral communication: Impact of safety margins and cess: retrospective analysis of four swiss center. 21st European Plastic Surgical Week. reconstructed breast with autologous fat grafting: lymphnodes on outcome in colorectal cancer. Bern, Switzerland, 21st-23rd May 2014. Oral communication: Engraftment of a free single centre analysis of surgery-related morbidity Interlaken, Switzerland, 11th September 2014. flap despite early pedicle thrombosis due to and graft resorption. Engelberger S, Salomon du Mont L, Holzer T, antithrombin III deficiency. Geneva, Switzerland, 5th-6th September 2014. Christoforidis D. Dubuis C, Saucy F, Deglise S, Corpataux J-M. Galtür, Austria, January 2014. Corso di aggiornamento regionale Ticinese OMCT. Le 101e Congrès annuel de la Société Suisse de Harder Y. Oral communication: Chirurgia colorettale sempre Chirurgie. Harder Y. Joint Swiss and Austrian Society of Senology meno invasiva: sviluppi tecnici. Oral communication: Early experience with the 21st European Plastic Surgical Week. Congress - Senoforum 2014. Manno, Switzerland, 12th November 2014. Innova TM self expanding stent system in the Oral communication: Rapidly growing histologically Oral communication: Microvascular lymph node treatment of femoropopliteal occlusive disease. confirmed female breast in a genotypically con- transfer to treat chronic lymphedema: One

152 Scientific Report 2014 7. Publications in 2014 153 surgical option? peripheren Nerven und Gefässe (DAM). Chirurgie. Chirurgie. Lugano, Switzerland, 11th-12th September 2014. Oral communication: Die Mikrovaskuläre Poster: An unlucky combination: a rare case of Oral communication: Ligation of intersphincteric Lymphknotentransplantation: Was wissen wir talus and scaphoid pseudarthrosis. fistula track (LIFT) for transsphincteric anal fistula: Harder Y. heute? Bern, Switzerland, 21st-23rd May 2014. initial experience. 45. Jahrestagung der Deutschen Gesellschaft der Zurich, Switzerland, 11th-13th December 2014. Bern, Switzerland, 21st-23rd May 2014. Plastischen, Rekonstruktiven und Ästhetischen Minervini F, Mezzetto L, Dessì K, Tschurtschenthaler Chirurgen (DGPRÄC). 19. Jahrestagung der Harder Y, Allan AA, Eder M, Müller DF, Kovacs L, I, Merlani P, Giovannacci L, Rosso R. Pravini B, Rosso R, Christoforidis D. Vereinigung der Deutschen Ästhetisch-Plastischen Schantz JT, Machens HG. Le 101e Congrès annuel de la Société Suisse de 9th Scientific and Annual Meeting of the European Chirurgen (VDÄPC) & 52. Jahrestagung 45. Jahrestagung der Deutschen Gesellschaft der Chirurgie. Society of Coloproctology. Österreichischen Gesellschaft für Plastische, Plastischen, Rekonstruktiven und Ästhetischen Oral communication: Carotid surgery for sympto- Poster: Ligation of intersphincteric fistula track for Ästhetischen und Rekonstruktive Chirurgen Chirurgen (DGPRÄC), 19. Jahrestagung der matic octogenarian patients: a single centre, ret- transsphincteric fistula: initial experience. (ÖGPÄRC). Vereinigung der Deutschen Ästhetisch-Plastischen rospective analysis. Barcelona, Spain, 24th- 26th September 2014. Oral communication: Vom “surgical delay” bis Chirurgen (VDÄPC) & 52. Jahrestagung Bern, Switzerland, 21st-23rd May 2014. zur nicht invasiven Gewebekonditionierung – Ein Österreichischen Gesellschaft für Plastische, Rezaeian F, Harder Y. historischer Überblick. Ästhetischen und Rekonstruktive Chirurgen Müller DF, Harder Y, Kwak M, Eder M, Kovacs L, 45. Jahrestagung der Deutschen Gesellschaft der Munich, Germany, 11th-13th September 2014. (ÖGPÄRC). Machens HG. Plastischen, Rekonstruktiven und Ästhetischen Oral communication: Einfluss von Nikotin 45. Jahrestagung der Deutschen Gesellschaft der Chirurgen (DGPRÄC). 19. Jahrestagung der Harder Y. und Bestrahlung auf die Resorption von Plastischen, Rekonstruktiven und Ästhetischen Vereinigung der Deutschen Ästhetisch-Plastischen International Conference on Repair, Regeneration transplantiertem Eigenfett zur Korrektur Chirurgen (DGPRÄC). 19. Jahrestagung der Chirurgen (VDÄPC) & 52. Jahrestagung and Reconstruction. von Sekundärdefekten nach rekonstruktiven Vereinigung der Deutschen Ästhetisch-Plastischen Österreichischen Gesellschaft für Plastische, Oral communication: Autologous fat grafting as a Brusteingriffen. Chirurgen (VDÄPC) & 52. Jahrestagung Ästhetischen und Rekonstruktive Chirurgen therapeutic agent: Is there a state of the art? Munich, Germany, 11th-13th September 2014. Österreichischen Gesellschaft für Plastische, (ÖGPÄRC). London, United Kingdom, 25th–27th September Ästhetischen und Rekonstruktive Chirurgen Oral communication: Experimentelle Ansätze zur 2014. Harder Y, Wettstein R, Rezaeian F, Schmauss D, (ÖGPÄRC). nicht invasiven Gewebepräkonditionierung in der Menger MD, Machens HG. Oral communication: 3,5 Jahre freie Plastischen Chirurgie. Harder Y. 36. Jahrestagung der Deutschsprachigen Lymphknotentransplantation zur Behandlung des Munich, Germany, 11th-13th September 2014. Symposium – Interdisziplinäre Behandlung des Arbeitsgemeinschaft für Mikrochirurgie der chronischen Lymphödems – Nutzen und Risiken. Mammakarzinoms. peripheren Nerven und Gefässe (DAM). Munich, Germany, 11th-13th September 2014. Rezaeian F, Schmauss D, Wettstein R, Erni D, Oral communication: Supermikrochirurgische Oral communication: Erhöhte Prädisposition Menger MD, Giovanoli P, Machens HG, Harder Y. Strategien zur Behandlung des chronischen Lym- für ischämiebedingte Lappenkomplikationen im Pototschnig H, Machens HG, Müller DF, Harder Y. 50. Kongress der Schweizerischen Gesellschaft phödems. fortgeschrittenen Alter als Folge einer verminderten 45. Jahrestagung der Deutschen Gesellschaft der für Plastische, Rekonstruktive und Ästhetische Ludwigshafen, Germany, 27th September 2014. Reaktionsfähigkeit der Kapillargefäße. Plastischen, Rekonstruktiven und Ästhetischen Chirurgie (SGPRAC) & 2. Jahrestagung der Zurich, Switzerland, 11th-13th December 2014. Chirurgen (DGPRÄC). 19. Jahrestagung der Gesellschaft für Ästhetische Chirurgie (SGÄC). Harder Y, Müller D, Kwak MS, Wagner S, Machens Vereinigung der Deutschen Ästhetisch-Plastischen Oral communication: From “surgical delay” to non- HG. Iriberri I, Candrian C, Freehill MT, Raiss P, Boileau Chirurgen (VDÄPC) & 52. Jahrestagung invasive tissue preconditioning in plastic surgery: a 15. Unionstagung der Schweizerischen P, Walch G. Österreichischen Gesellschaft für Plastische, historical overview. Gesellschaften für Gefässkrankheiten (USGG). AAOS Annual Meeting. Ästhetischen und Rekonstruktive Chirurgen Geneva, Switzerland, 5th-6th September 2014. Oral communication: Reconstruction of non- Poster: Should Reverse Total Shoulder (ÖGPÄRC). functional lymph node basins using microvascolar Arthroplasty be the Index Procedure in Over 80 Oral communication: Lappenüberleben durch Rosso R. lymph node transfer in chronic lymphedema. Year Old Patients? frühzeitiges Engraftment nach AT-3-Mangel- The 31th International Gastrointestinal Surgery St. Gallen, Switzerland, 12th-14th November 2014. New Orleans, Louisiana, USA 11th-15th March assoziierter Pedikel-Thrombose. Workshop 2014. 2014. Munich, Germany, 11th-13th September 2014. Oral communication: Acute situations in abdomi- Harder Y. nal surgery: clinical scenarios I. 36. Jahrestagung der Deutschsprachigen Mazzucchelli RA, Müller J, Candrian C. Pravini B, Rosso R, Christoforidis D. Davos, Switzerland, 22nd-28th February 2014. Arbeitsgemeinschaft für Mikrochirurgie der Le 101e Congrès annuel de la Société Suisse de Le 101e Congrès annuel de la Société Suisse de

154 Scientific Report 2014 7. Publications in 2014 155 Rosso R. ierung zur Verhinderung von Ischämie-assoziierten Inflammatory Bowel Diseases. In: Bruera E, Higginson I, von Gunten CF, Morita The 31th International Gastrointestinal Surgery Wundheilungsstörungen und Hautnekrosen – eine In: Cistaro A, editors. Atlas of PET/CT in Pediatric T, editors. Textbook of Palliative Medicine and Workshop 2014. klinische Pilotstudie an der Brust. Patients. Springer; 2014:199-200. ISBN: 978-88- Supportive Care. 2nd ed. 2014. Oral communication: Open abdomen – therapeutic Munich, Germany, 11th-13th September 2014. 470-5357-1 (Print) 978-88-470-5358-8 (Online). options for closure of laparostomy. Davos, Switzerland, 22nd-28th February 2014. van Aaken J, Fusetti C, Lucchina S, Beaulieu JY, Treglia G, Cistaro A. Hofmeister E. Mycobacteriosis. Rosso R. SGH-SSCM. In: Cistaro A, editors. Atlas of PET/CT in Pediatric Schweizerische Gesellschaft für Allgemein Non inferiority of treating boxer's fracture with soft Patients. Springer, 2014:217-219. ISBN: 978-88- Chirurgie und Traumatologie (SGATC) 18. Bieler cast compared to reduction and cast. 470-5357-1 (Print) 978-88-470-5358-8 (Online). Fortbildungstage. Thun, Switzerland, 13th-14th November 2014. Oral communication: Prise en charge de la Treglia G, Cistaro A. cholécystite chez la femme enceinte. Publications in books in 2014 Neurofibromatosis. Biel, Switzerland, 4th-5th September 2014. In: Cistaro A, editors. Atlas of PET/CT in Pediatric Interventional Radiology Patients. Springer, 2014:229-231. ISBN: 978-88- Schaefer DJ, Tchang LAH, Largo RD, Harder Y, 470-5357-1 (Print) 978-88-470-5358-8 (Online). Wettstein R, Pittet B. van den Berg JC. 50. Kongress der Schweizerischen Gesellschaft Internal iliac artery embolization as an adjunct to Treglia G, Cistaro A. für Plastische, Rekonstruktive und Ästhetische endovascular aneurysm repair. Sarcoidosis. Chirurgie (SGPRAC) & 2. Jahrestagung der In: JC Stanley, FJ. Veith, TW. Wakefield, editors. In: Cistaro A, editors. Atlas of PET/CT in Pediatric Gesellschaft für Ästhetische Chirurgie (SGÄC). Current therapy in vascular and endovascular Patients. Springer, 2014:223-228. ISBN: 978-88- Oral communication: Swiss recommendations for surgery. 470-5357-1 (Print) 978-88-470-5358-8 (Online). autologous fat grafting in the breast. Philadelphia, Elsevier Saunders, 2014:253-256. Geneva, Switzerland, 5th-6th September 2014. Treglia G, Salsano M, Annunziata S. Neurology PET tracers in glioma imaging. Schmauss D, Finck T, Mehta S, Farhadi J, Egana In: Adamson DC, editors. Gliomas: Classification, JT, Machens HG, Harder Y. Pignatti R. Symptoms, Treatment and Prognosis. Nova 101. Kongress der Schweizerischen Gesellschaft Neuropsychology of Anorexia Nervosa. Publisher, 2014:139-143. für Chirurgie (SGC). In: Sassaroli S, Ruggiero GM, editors. New ISBN:978-1-63117-868-9 (Print) ISBN: 978-1- Oral communication: Local heat preconditioning Developments in Anorexia Nervosa Research. 63117-875-7 (Online). to prevent wound breakdown and skin necrosis: A Hauppauge, NY, Nova Science Publishers, translational study. 2014:75-94. Oncology Bern, Switzerland, 21st-23rd May 2014. Nuclear Medicine Zucca E, Bertoni F, Cavalli F. Schmauss D, Finck T, Mehta S, Farhadi J, Egaña T, MALT and other marginal zone lymphoma. Chapter Machens HG, Harder Y. Taralli S, Stefanelli A, Treglia G. 7. 45. Jahrestagung der Deutschen Gesellschaft der Role of PET in Cancer Diagnosis. In: Marcus R, Sweetenham JW, Williams ME Plastischen, Rekonstruktiven und Ästhetischen In: Barh D, Carpi A, Verma M, Gunduz M, editors. editors. Lymphoma. Pathology, Diagnosis, and Chirurgen (DGPRÄC). 19. Jahrestagung der Cancer Biomarkers: Minimal and Noninvasive Early Treatment. 2nd ed. Cambridge University Press, Vereinigung der Deutschen Ästhetisch-Plastischen Diagnosis and Prognosis. CRC Press, 2014:39- Cambridge, 2014. Chirurgen (VDÄPC) & 52. Jahrestagung 46. Österreichischen Gesellschaft für Plastische, ISBN: 978-1-4665-8428-0 (Print), 978-1-4665- Palliative Care Ästhetischen und Rekonstruktive Chirurgen 8429-7 (Online). (ÖGPÄRC). Gamondi C, Neuenschwander H. Oral communication: Lokale Hitzepräkondition- Treglia G, Alongi P. Pathophysiology of fatigue.

156 Scientific Report 2014 7. Publications in 2014 157 8 Appendices 8. Appendices

Appendix 1 - Research projects funded by ABREOC in 2008

Lead Investigator Other researchers Institute Study title Status report (December 2014) Andreas Perren Roberto Malacrida / Elena Iapichino/ Davide Corbella / Fabrizio Barazzoni / Regional Hospital of Bellinzona Contenzione fisica vs farmacologica nel paziente intu- Closed. Publication still ongoing Valentina di Bernardo / Ines Sperandino/ Cristina Sommacal and Valli - Intensive Care Medicine bato: conseguenze cliniche (Physical vs. drug restraint in the intubated patient: clinical consequences) Gianfranco John Petri Fabio Garofalo / Robin Chanda / M. Lazzaro / Luca Deabate / F. Strano / Regional Hospital of Bellinzona Diabete in ortopedia: gestione peri-operatoria del Closed. (final report presented) Paola Genini / Ivana Roguljic and Valli - Orthopaedics paziente diabetico - Infusione endovenosa continua d'insulina rapida (IECI) versus correzioni con insulina sottocute (regime standard) (Diabetes in orthopedics: perioperative management of the diabetic patient - a continuous intravenous infusion of rapid insulin (IEC) versus corrections with subcutaneous insulin (standard regimen)) Piercarlo Saletti Sara De Dosso / Milo Frattini / Luca Mazzucchelli / Emanuele Zucca IOSI Oncology Analisi dei marcatori molecolari ERCC-1, TS, p53 e Closed and published in Cancer Chemother pTEN in pazienti affetti da adenocarcinoma gastrico o Pharmacol, 72(1):159-65, 2013: "ERCC1 predicts della giunzione esofagogastrica operati radicalmente e outcome in patients with gastric cancer treated with sottoposti a chemioterapia precauzionale (Analysis of adjuvant cisplatin-based chemotherapy" molecular markers ERCC-1, TS, p53 and PTEN in pa- tients affected by gastric or esophagogastric junction adenocarcinoma, who are radically operated and have undergone a preventive chemotherapy) Olivia Pagani Monica Taborelli / Gabriella Bianchi-Micheli / Manuela Sarti IOSI Oncology Analisi della qualità dell'informazione nei colloqui di con- Closed. Publication still ongoing sulenza genetica per predisposizione a malattie tumorali (Analysis of the quality of information in genetic coun- seling for predisposition to cancer diseases) Luca Giovanella Luca Ceriani / Franco Keller IOSI Nuclear Medicine Metabolismo calcico nel morbo di Basedow Closed and published in Eur J Clin Invest, 41(1):93-7, (Calcium metabolism in Basedow disease) 2011: "Evaluation of serum parathyroid hormone- related peptide in hyperthyroid patients" Luca Giovanella / Luca Mazzucchelli / Luca Ceriani / Sergio Suriano IOSI Nuclear Medicine/Oncology Significato prognostico della 18fdg-PET/CT (Prognostic In progress Emanuele Zucca significance of 18fdg-PET/CT) Mario Bianchetti Peter Johannes Schulz / Maria Caiata Zufferey Regional Hospital of Bellinzona Convivere con una malattia cronica e genetica: il caso Closed and published in Nephrol Dial Transplant, and Valli - Paediatrics della sindrome di Gitelman (Living with a chronic and ge- 27(8): 3196-3201, 2012: "Living with Gitelman dis- netic disease: the Gitelman syndrome) ease: an insight into patients' daily experiences" Michele Ghielmini Jürg Stamm / Alden Moccia / Alessandra Fusconi IOSI Oncology Preservazione della fertilità mediante crioconservazione In progress di tessuto ovarico (Fertility preservation through cryo- preservation of ovarian tissue)

160 Scientific Report 2014 8. Appendices 161 Appendix 2 - Research projects funded by ABREOC in 2009

Lead Investigator Other researchers Institute Title Status report (December 2014) Olivia Pagani Aron Goldhirsch / Franco Cavalli / Laura Richetti IOSI - Oncology Database CARMA: raccolta di dati clinici, retrospettivi In progress e prospettici, in pazienti con carcinoma mammario per valutare l’impatto sull’outcome dei fattori prognostici e predittivi identificati alla diagnosi (CARMA database: collection of retrospective and prospective clinical data in breast cancer patients to assess the impact on out- come of prognostic and predictive factors identified when diagnosed) Luca Giovanella Franco Keller / Sergio Suriano IOSI nuclear Medicine Procalcitonina e carcinoma midollare tiroideo (Procalci- Closed and published in Clin Chem Lab Med, tonin and medullary thyroid carcinoma) 51(7):1477-81, 2013: "Comparison of serum calci- tonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules" Gian Paolo Ramelli Alessandra Ferrarini Regional Hospital of Bellinzona Creazione di una banca dati dei pazienti pediatrici con Closed and published in Dev Med Child Neurol, and Valli - Paediatrics ritardo mentale assistiti dal Servizio di Neuropediatria 56(3):290, 2014: "Chromosomal microarray among dell’Ospedale Regionale di Bellinzona e Valli, Bellinzona, children with intellectual disability: a useful diagnostic San Giovanni (Database creation of pediatric patients tool for the clinical geneticist" with mental retardation assisted by neuropaediatrics Service of the Regional Hospital of Bellinzona and Valli, Bellinzona, San Giovanni) Martin Bolli Riccardo Vandoni / Luca Mazzucchelli / Milo Frattini Regional Hospital of Bellinzona Espressione e ruolo prognostico di marcatori moleco- Closed (final report presented) and Valli - Surgery lari, biologici e clinici nell'epatocarcinoma (Expression and prognostic role of molecular, biological and clinical markers in hepatocarcinoma) Carlo Cereda Claudio Bassetti / Claudio Staedler / Laura Zampieri / Antonio Carota Regional Hospital of Lugano - Impatto sanitario dell’implementazione di una struttura In progress Neurocenter of Southern Switzerland di cure continue neurologiche (Stroke Unit) in seno al (NSI) Neurocentro (EOC) della Svizzera Italiana - studio os- servazionale community-based sulle malattie cerebro- vascolari acute in territorio ticinese. (Health impact of a structure of continuous neurological treatment (stroke unit) within the Neurocenter (EOC) of Southern Switzer- land- observational community-based study of acute cer- ebrovascular diseases in Ticino) Pierluigi Quadri Fabiano Meroni /Rita Pezzati / Damiano Zemp / Lorena Curia/ Carola Regional Hospital of Mendrisio - La paura di cadere negli anziani: intervento fisioterapico Closed (ongoing data analysis) Celeste / Silvia Ambrogio / Simona Chiari / Francesca Gallina / Nicola Geriatrics e approccio cognitivo (imagery) (Fear of falling in the el- Schiavone / Gianluca Guffanti derly: physiotherapy intervention and cognitive approach (imagery)) Claudia Gamondi M. Caiata Zufferey / Joyce Pellandini IOSI Oncology (Palliative Care Unit) Assisted Suicide: attitudes and experiences of bereaved Closed and published in Ann Oncol, 24(6):1639-44, families and beloved ones. An exploratory study 2013: "Families’ experiences with patients who died after assisted suicide: a retrospective interview study in southern Switzerland" Emanuele Zucca Francesco Bertoni / Marco Zaffalon / Cassio Polpo de Campos IOSI Oncology Sviluppo di nuovi algoritmi per l'identificazione di mod- Closed and publication is ongoing in Computational elli prognostici in pazienti affetti da linfomi mediante Statistics and Data Analysis l'ottimizzazione della gestione dei dati mancanti (Devel- opment of new algorithms for the identification of prog- nostic models in patients with lymphomas by optimizing the management of missing data) Marcello Di Valentino Augusto Gallino / Stefano Muzzarelli Regional Hospital of Bellinzona No Smoke Pub Study Closed and published in Eur J Public Health. 2014; and Valli - Cardiology pii: cku067. [Epub ahead of print]: Reduction of ST- elevation myocardial infarction in Canton Ticino (Switzerland) after smoking bans in enclosed public places-: No Smoke Pub Study Michele Ghielmini Oreste Mora / Lucia Marelli / Carla Pedrazzani / Monica Bianchi / Mauro IOSI Oncology Fattibilità e accettabilità di una valutazione rapida multi- Closed. Publication still ongoing Tettamanti / Pierluigi Quadri dimensionale per il paziente oncologico anziano: studio pilota osservazionale (Feasibility and acceptability of a quick multidimensional assessment for the elderly can- cer patient: an observational pilot study)

162 Scientific Report 2014 8. Appendices 163 Appendix 3 - Research projects funded by ABREOC in 2010

Lead Investigator Other researchers Institute Study title Status report (December 2014) Rolf Wyttenbach Zsolt Szücs-Farkas / Nathalie Médioni Regional Hospital of Bellinzona Extracardiac Findings on Cardiac Magnetic Resonance Closed and published in Eur Radiol, 22(6):1295-302, and Valli - Radiology Imaging Studies 2012:"Extracardiac findings detected by cardiac magnetic resonance imaging"

Luca Giovanella Franco Keller / Sergio Suriano / Luca Ceriani IOSI Nuclear Medicine Dosaggio calcitonina su agoaspirato tiroideo (Dosage of Closed and published in Diagn Cytopathol, 41(3): 226- calcitonin in thyroid fine-needle aspiration) 229, 2013: "Calcitonin measurement on fine needle washouts: preanalytical issues and normal reference values" and in Clin Endocrinol (Oxf), 80(1):135-140, 2014: "Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: a retrospective multicentre study" Luca Giovanella Luca Ceriani / Sergio Suriano / Riccardo Ricci IOSI Nuclear Medicine Diagnosi differenziale dei noduli tiroidei con citologia non- Closed (ongoing data analysis) diagnostica mediante 18FDG-PET/CT (Differential diag- nosis of thyroid nodules with non-diagnostic cytology by 18FDG-PET/CT) Luca Giovannacci Raffaele Rosso / Filippo Del Grande / Reto Canevascini / Stephane Regional Hospital Fattibilità di un programma di screening ecografico Closed. Publication still ongoing. Schlunke / Josua van den Berg / Hans Stricker of Lugano - Vascular Surgery dell'aneurisma dell'aorta addominale nella popolazione afferente all'Ospedale Regionale di Lugano (Feasibility of a abdominal aortic aneurysm ultrasound screening program in the population served by Regional Hospital of Lugano) Gian Paolo Ramelli Tamara Gonzalez / Nadia Zanda / Emanuelle Rossini ORBV Paediatrics Creazione di una banca dati dei pazienti pediatrici con Closed and published in Eur J Paediatr Neurol, 19 disturbo dello spettro autistico assistiti dal Servizio di (3): 386-387, 2015: "High prevalence of pathologic Neuropediatria dell’Ospedale Regionale di Bellinzona copy number variants detected by chromosomal mi- e Valli, Bellinzona (San Giovanni) (Database creation of croarray in Swiss-Italian children with autism spec- paediatric patients with autism spectrum disorder as- trum disorders" sisted by neuropaediatrics Service of Regional Hospital of Bellinzona and Valli, Bellinzona (San Giovanni) Michele Ghielmini Andrea Bordoni / Luca Mazzucchelli / Alessandra Spitale IOSI Oncology Indicatori di qualità nel trattamento oncologico: progetto Closed and published in BMJ Open, 3(7), 2013: di ricerca nella Svizzera Italiana (Indicators of Quality of "Quality indicators of clinical cancer care (QC3) in Cancer Care in Southern Switzerland) colorectal cancer"; in Schweizer Krebsbulletin, 3: 205-208, 2012: "Quality Indicators of Clinical Can- cer Care (QC3) in the territory of Canton Ticino: a population-based study"; in Tribuna Medica Ticinese, 76: 51-55, 2011: "Indicatori di qualità nelle cure on- cologiche studio QC3" Augusto Gallino Marcello Di Valentino / Julija Klimusina / Regional Group of Ticino cardiologists Regional Hospital Sindrome X coronarica: ruolo della funzione endoteliale: Closed and published in Cardiovascular Medi- of Bellinzona and Valli - Cardiology un sotto-studio della coorte svizzera italiana del registro cine,16(1): 20–28, 2013: "Cardiac X syndrome: an italiano sulla sindrome X (Cardiac X Syndrome: role of overview of the literature and the local experience in endothelial function: a substudy of the Swiss-Italian co- Southern Switzerland" hort of the italian Registry on X Syndrome) Andrea Menafoglio Marcello Di Valentino / Reto Pezzoli / Julija Klimusina / Augusto Gallino Regional Hospital Impatto dello screening cardiovascolare con elettrocar- Closed and published in Cardiovascular Medicine, of Bellinzona and Valli - Cardiology diogramma in giovani atleti (Impact of cardiovascular 16:11-19, 2013 screening with ECG in young (12-35 years) competitive athletes) Dario Valcarenghi Paola Di Giulio / Monica Bianchi / Carla Pedrazzani / Sonia Tosi Casado / IOSI nursing Service La sorveglianza del dolore allo IOSI: a che punto siamo? Closed (final report presented) Christa Pedrazzoli Hutz (Pain monitoring at the IOSI: where are we?) Claudio Gobbi Chiara Zecca / Ursula Candrian / Marta Garcia Calle / Mara Gola / Regional Hospital of Lugano - A prospective, randomized, double-blind, placebo-con- In progress Costanzo Limoni / Liliane Petrini Neurocenter of Southern trolled, parallel-group, phase IV study of oral prednisone Switzerland (NSI) taper vs. placebo following intravenous steroids for the treatment of acute relapses in multiple sclerosis within the Ticino cohort

164 Scientific Report 2014 8. Appendices 165 Lead Investigator Other researchers Institute Study title Status report (December 2014) Piercarlo Saletti Milo Frattini / Luca Mazzucchelli / Sara De Dosso IOSI Oncology Ruolo predittivo di EGFR, PIK3CA e PTEN nella risposta In progress al trattamento radio-chemioterapico preoperatorio in pazienti affetti da carcinoma rettale localmente avanza- to (Predictive role of EGFR, PIK3CA and PTEN in the re- sponse to preoperative radio-chemotherapy in patients with locally advanced rectal carcinoma) Roberto Malacrida Valentina Di Bernardo / Nicola Grignoni / Chantal Marazia / Andreas Regional Hospital of Lugano - L'intimità nelle cure intensive del Canton Ticino (Intimacy Closed. Publication still ongoing Perren / Michael Llamas / Alberto Pagnamenta / Ines Sperandio / intensive care Medicine in the intensive care unit of the Canton Ticino) Rosanna Di Nocolantonio / Attilio Sicilia / Barbara Schulte

Alberto Pagnamenta Moreno Doninelli / Michael Llamas / Andreas Perren / Roberto Malacrida Regional Hospital of Mendrisio - Impatto di una strategia comunicativa sulla soddisfazi- Closed. Publication still ongoing / Kurt Schmidlin / Hans Ulrich Rothen intensive care Medicine one dei familiari in medicina intensiva (Impact of a com- munication strategy on the relatives' satisfaction in in- tensive care medicine) Manuela Sarti Sandra Pinton / Pina Carbone / Carlo Catapano / Enrico Roggero / IOSI Oncology Expression analysis of putative stem cell markers in Closed and presented as scientific communica- Franco Cavalli human malignant prostate tumour and prognostic tions at national and international conferences and implications published in Nature, 515(7525): 134-137, 2014: "Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer" Dario Valcarenghi Monica Bianchi / Claudia Gamondi Palmesino / Sonia Tosi Casado / IOSI nursing Service / Oncology L'inserimento di un programma di arte-terapia per Closed (final report presented) Christa Pedrazzoli Hutz / Carla Pedrazzani pazienti oncologici ricoverati allo IOSI: uno studio pilota (Introduction of art therapy program for cancer pa- tients admitted to the IOSI: a pilot study) Enrico Roggero Barbara Marongiu / Mariarosa Pascale / Andrea Alimonti / Flavio Stoffel IOSI Oncology Studio pilota per confrontare i profili genomici e metabo- Closed and published in Tribuna medica ticinese, / Franco Cavalli lomici di pazienti con cancro alla prostata alla diagnosi 79: 245-248, 2014: "Gestione multidisciplinare dei e durante la progressione della malattia con lo scopo di pazienti con tumori urogenitali presso l'ente ospe- identificare specifiche alterazioni genetiche e metaboli- daliero cantonale" che intra-individuali (Pilot study comparing genomic and metabolomic profiling of patients with prostate cancer at diagnosis and during disease progression to find specific intra-individual genetic and metabolic alterations)

166 Scientific Report 2014 8. Appendices 167 Appendix 4 - Research projects funded by ABREOC in 2011

Lead Investigator Other researchers Institute Study title Status report (December 2014) Luca Giovanella Massimo Bongiovanni / Sergio Suriano IOSI nuclear Medicine Noduli tiroidei con citologia indeterminata: ruolo diagnos- In progress tico di elastosonografia e marcatori immunocitochimici. (Thyroid nodules with indeterminate cytology: diagnostic role of elastography and immunocytochemical markers) Claudia Gamondi Chantal Corti Polti / Murielle Pott IOSI Oncology (Palliative Care Unit) Parteciper à un suicide assisté: étude exploratoire sur Closed. Publication still ongoing l'expérience des proches et leurs représentations de la fin de vie, de la mort et du deuil. (The experience of the family in assisted suicide) Claudia Gamondi Paola Di Giulio / Michele Egloff IOSI Oncology (Palliative Care Unit) Epidemiology of dying in Southern Switzerland: circum- Closed (ongoing data analysis) stances of death. Dimitri Christoforidis Mike Schmalzbauer / Alberto Posabella / Raffaele Rosso Regional Hospital of Lugano - Surgery Due tecniche chirurgiche per il trattamento delle cisti In progress sacro-coccigee: uno studio randomizzato e controllato (Two surgical techniques for the treatment of sacro- coccygeal cysts: a randomized and controlled study) Florian Bihl Antonio Lanzavecchia Regional Hospital of Bellinzona Valutazione della risposta immunitaria cellulare nei con- In progress and Valli - Gastroenterology fronti del virus dell'epatite B in vari stadi dell'infezione: caratterizzazione di risposte di linfociti T e B ed analisi di nuovi epitopi virali (Evaluation of the cellular immune response against the hepatitis B virus in various stages of infection: characterization of responses of T and B lymphocytes and analysis of new viral epitopes) Christina Caporale/ Claudio Bassetti / Fabio Conti / Claudio Petrillo / René Müri / Thomas Regional Hospital of Lugano - Riabilitazione combinata alla stimolazione biemisferica In progress Carlo Cereda Nyffeler / Antonino Uncini / Daniel Zutter Neurocenter of Southern transcranica con corrente continua diretta in pazienti Switzerland (NSI) con ictus subacuto al fine di aumentare il recupero mo- torio degli arti superiori. (Rehabilitation combined with bihemispheric transcranial direct current stimulation in subacute ischemic stroke to increase upper limb motor recovery) Franco Keller Mauro Imperiali / Roberto Della Bruna/ Luca Martinolli EOLAB Department Valutazione dell'introduzione di apparecchi POCT per Closed (presented at "Congresso Svizzero di me- l'emogasanalisi nell'urgenza ospedaliera e pre-ospe- dicina di laboratorio -Swiss conference of laboratory daliera (Evaluation of the introduction of POCT devices medicine (Swiss medLab)" for blood gas analysis in the hospital and pre-hospital emergency) Marco Pons Andrea Azzola / Alessia Riglietti / Claudio Bassetti / Mauro Manconi / Carlo Regional Hospital Le apnee centrali in corso di TIA/ictus ischemico: el- In progress Cereda / Liliane Petrini / Guido Ferretti / Massimo Pagani / Fabio Esposito / of Lugano - internal Medicine ementi clinici, prognostici e fiosiopatologici (The central Costanzo Limoni apneas during the TIA / ischemic stroke: clinical, prog- nostic and physiopathological elements) Rolf Wyttenbach Stefano Colagrande / Francesco Regini / Elisa Ardemagni Regional Hospital of Bellinzona Multi-parametric evaluation of liver perfusion by MR-Dwl closed and published in J Comput Assist Tomogr, and Valli -Radiology under fasting and postprandial conditions in healthly 2015 Feb 13 [Epub ahead of print]: "Assessment volunteers: correlation with quantitative phase-contrast of Liver Perfusion by IntraVoxel Incoherent Motion portal venous flow measurements (IVIM) Magnetic Resonance-Diffusion-Weighted Im- aging: Correlation With Phase-Contrast Portal Ve- nous Flow Measurements" Salvatore Galati Carsten Möller / Claudio Städler/ Chiara Prosperetti / Mauro Manconi / Regional Hospital of Lugano - Ruolo della sleep homeostasis nello sviluppo delle disci- In progress Simone Sarasso / Marcello Massimini Neurocenter of Southern nesie indotte dalla L-Dopa nei pazienti affetti da malattia Switzerland (NSI) di Parkinson in fase avanzata (Role of sleep homeostasis in the development of dyskinesias induced by L-dopa in patients with advanced stage of Parkinson's disease) Gianfranco Pesce Azinwi Ngwa Che / Antonella Richetti / Jolanda De Jong IOSI Radio-Oncology Protocollo di irradiazione cerebrale ipofrazionata o ra- In progress diochirurgia (IGRT o modalità stereotassica della cavità di resezione in pazienti sottoposti ad asportazione chi- rurgica di metastasi cerebrale singola da tumori solidi (Hypofractionated cerebral irradiation protocol or ra- diosurgery (IGRT or stereotaxic mode) of the resection cavity in patients undergoing surgical removal of single cerebral metastasis from solid tumours)

168 Scientific Report 2014 8. Appendices 169 Appendix 5 - Research projects funded by ABREOC in 2012-2013

Lead Investigator Other researchers Institute Study title Status report (December 2014) Andrea Menafoglio Marcello Di Valentino / Patrick Siragusa / Gian-Antonio Romano / Reto Regional Hospital of Bellinzona Impatto dello screening cardiovascolare in atleti master tra 35 e 65 anni (Pre- Closed and published in Br Pezzoli / Giorgio Moschovitis and Valli - Cardiology participation Screening and Assessment of Cardiovascular diseases in Masters J Sports Med. 2014 Nov Athletes (PSA-Masters Study)) 13 [Epub ahead of print]: "Cardiovascular evaluation of middle-aged individuals engaged in high-intensity sport activities: implications for workload, yield and economic costs" Leonardo Sacco Leonardo Sacco / Guido Ongaro / Fabiano Meroni / Riccardo Pignatti / Regional Hospital of Lugano - L'alterazione di A-BETA 42, TAU e FOSFO-TAU nel liquor di pazienti con deficit In progress Claudio Staedler / Franco Keller Neurocenter of Southern cognitivo lieve (CDR 0.5) sono indice indiretto di accumulo di amiloide e danno Switzerland (NSI) neuronale. I test di memoria semantica, memoria ecologica e dual task sono congruenti con il processo neurodegenerativo? (The alteration in A-BETA 42, TAU and PHOSPHO-TAU in the cerebrospinal fluid of patients with mild cognitive impairment (CDR 0.5) is an indirect sign of amyloid accumulation and neuronal damage. Are semantic memory, ecological memory and dual task tests consist- ent with the neurodegenerative process?) Enos Bernasconi Francesco Bertoni / Emanuele Zucca / Stephan Dirnhofer Regional Hospital of Lugano - A survey of treatment modalities and outcome analysis of HIV-related B-cell lym- Closed. Publication still Infectious diseases phomas from the Swiss HIV Cohort Study ongoing Dario Valcarenghi Monica Bianchi / Carla Pedrazzani / Agostino Chiriatti / Massimiliano IOSI nursing Service L'educazione del paziente al trattamento farmacologico antitumorale orale (Pa- Closed (ongoing data Zanon tient education to oral cancer therapy) analysis) Luciano Wannesson Milo Frattini / Luca Mazzucchelli / Francesca Molinari IOSI Oncology Analisi dell'espressione genica di ROR1 nei carcinomi polmonari: un nuovo mar- In progress catore nell'ottica di nuove terapie bersaglio-specifiche (Gene expression analysis of ROR1 in lung carcinomas: a new marker in view of new target-specific thera- pies) Manuela Sarti Gianluca Civenni / Flavio Stoffel / Carlo Catapano / Giuseppina Carbone IOSI Oncology Isolation and characterization of epithelial stem cells from human prostate bi- In progress opsies Cristiana Sessa Sara De Dosso / Anastasios Stathis IOSI Oncology Studio di Fase I con la combinazione di chemioterapia contenente platino e endo- In progress metacina (Phase I study evaluating indomethacin in combination with platinum- based chemotherapy) Claudio Gobbi Emanuele Pravatà / Chiara Zecca / Valeria Pifferini / Navarajah Nadarajah / Regional Hospital of Lugano - Brain Default Mode and Attention Network MR Functional Connectivity Changes Closed (final report and a Alessandro Cianfoni / Leonardo Sacco / Riccardo Pignatti Neurocenter of Southern After Task-induced Precipitation of Cognitive Fatigue in Patients with Multiple poster presented at confer- Switzerland (NSI) Sclerosis ences) Mauro Imperiali / Franco Keller EOLAB Department / Studio di marcatori biochimici tiroidei (Study of thyroid biochemical markers) In progress Luca Giovanella IOSI nuclear Medicine Olivier Giannini Damiano Zemp / Claudio Cereghetti / Mauro Tettamanti / Pierluigi Quadri Regional Hospital of Mendrisio - Influenza dell'emodialisi sull'attività fisica e sulle capacità motorie in pazienti con In progress internal Medicine insufficienza renale cronica stadio 5 (K/DOQI) (Influence of haemodyalisis on physical activity and motor skills of patients with chronic kidney disease, stage 5 (K/DOQI). Mario G. Bianchetti Giacomo D. Simonetti / Alberto Bettinelli / Francesco Barretta Regional Hospital of Bellinzona Meccanismi soggiacenti l'iponatriemia della polmonite del bambino acquisita in In progress and Valli - Paediatrics comunità (Mechanisms underlying hyponatremia of community-acquired pneu- monia in children) Alessandra Pia Augusto Gallino / Peter J. Schwartz /Isabella Sudano /Juljia Klimusina Regional Hospital of Bellinzona Cardiomiopatia di Tako-Tsubo e Sindrome X Cardiaca: nuove prospettive patofi- In progress Porretta and Valli - Cardiology siologiche nell'ambito di due cardiopatie orfane (Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: New Insights into the pathophysiology of two orphan car- diac diseases) Manuela Sarti Carlo Catapano / Giuseppina Carbone / Enrico Roggero / Sandra Pinton IOSI Oncology Circulating microRNAs in plasma/serum as biomarkers for prostate cancer In progress / Ramon Garcia-Escudero / Flavio Stoffel / Brunello Mazzola / Fernando Jermini / Mauro Castelnuovo Michele Ghielmini Vilma Ratti / Cristina Marini / Carla Pedrazzani IOSI Oncology Studio caso-controllo dell'impatto di una scelta terapeutica basata sulla valutazi- In progress one multidimensionale del paziente oncologico in età geriatrica (Case-control study of the impact of a therapeutic choice based on multi-dimensional assess- ment of elderly cancer patients)

170 Scientific Report 2014 8. Appendices 171 Appendix 6 - Research projects funded by ABREOC in 2014

Lead Investigator Other researchers Institute Study title Expected study duration Luca Giovanella Luca Ceriani / Pierpaolo Trimboli IOSI Nuclear Medicine Analisi Ecostrutturale quantitativa: ruolo diagnostico dif- 36 months ferenziale nella patologia nodulare tiroidea (Echostruc- tural quantitative analysis: differential diagnostic role in nodular thyroid disease) Luca Gabutti Igor Salvadé / Giorgia Bianchi Regional Hospital A. Valore predittivo del magnesio ionizzato sulla magne- 2 months (in progress) of Locarno - Internal Medicine semia totale e variazioni intradialitiche: uno studio di popolazione; B. Conseguenze emodinamiche del cambia- mento di concentrazione di magnesio nel dializzato: uno studio in cross-over (A. Predictive value of ionized mag- nesium on total magnesemia and intradialytic variations: a population study; B. Consequences of hemodynamic change in magnesium concentration in the dialysate: a cross-over study) Silvia Miano Mauro Manconi / Valdo Pezzoli / Gian Paolo Ramelli Regional Hospital Markers polisonnografici del disturbo dell’attenzione ed 24 months of Lugano - Neurocenter iperattività in età pediatrica e disturbi del sonno (Poly- of Southern Switzerland (NSI) somnographic markers of attention deficit and hyperac- tivity disorder in pediatric age and sleep disorders) Stephany Fulda Chiara Prosperetti Regional Hospital of Lugano - "Infra-slow oscillations during sleep in healthy subjects 18 months Neurocenter of Southern and subjects with restless legs syndrome/periodic leg Switzerland (NSI) movements during sleep (RLS/PLMS)" Enrico Roggero Luca Mazzucchelli / Mariarosa Pascale IOSI Oncology Studio pilota epidemiologico sulla prevalenza del virus 12 months del papilloma umano nei soggetti affetti da carcinoma della prostata nella popolazione ticinese (Epidemiological pilot study on prevalence of human papillomavirus in indi- viduals with prostate cancer in the population in Ticino) Giorgio Treglia Ramin Sadeghi / Salvatore Annunziata IOSI Nuclear Medicine Meta-analisi sull’accuratezza diagnostica della PET/TC 12 months con fluorodesossiglucosio nello studio dei tumori delle vie biliari (Meta-analysis on diagnostic accuracy of PET/ CT scans with fluorodeoxyglucose in the study of biliary tract tumours) Gianfranco Pesce Azinwi Ngwa Che / Antonella Richetti / Yolanda De Jong / Luca Giovanella / IOSI Radio-Oncology Radioterapia ipofrazionata ad alta conformazionalità 48 months Rolf Wyttenbach (IGRT) in pazienti con recidiva biochimica di adenocarci- noma della prostata e malattia oligometastatica: studio pilota prospettico di fase II (Highly conformational hypo- fractionated radiation therapy (IGRT) in patients with biochemical recurrence of prostate adenocarcinoma and oligometastatic disease: a prospective phase II pilot study) Carla Pedrazzani Dario Valcarenghi / Monica Bianchi / Christa Pedrazzoli Hutz / Andrea IOSI Nursing Service L'astenia nei pazienti oncologici allo IOSI (Asthenia in 12 months Bordoni cancer patients at the IOSI) Chiara Zecca Claudio Gobbi / Gianna Riccitelli / Alessandro Cianfoni / Emanuele Pravatà Regional Hospital of Lugano - Brain MRI functional connectivity and neuropsychologi- 30 months Neurocenter of Southern cal assessment in multiple sclerosis patients with mi- Switzerland (NSI) graine

Appendix 7 - 2014 EOC Projects subject to General Authorisation (AG) Collaborators (in addition Approval by Ethics to the LI) having access Expected study Committee of Canton No. Study title Lead Investigator (LI) Other researchers to non-anonymized data duration Ticino 1/AG14 Analisi dell'espressione genica di ROR1 nei carcinomi polmonari: un nuovo marcatore Luciano Wanesson Milo Frattini, Luca Milo Frattini, Luca Mazzuc- 12 months Approved nell'ottica di nuove terapie bersaglio-specifiche (Analysis of gene expression of ROR1 in Mazzucchelli, Francesca chelli, Samantha Epistolo, (7th May 2014) lung cancers: a new marker in view of new target-specific therapies) Molinari Francesca Molinari, Alice Ref. EC 2800 Riva, Giovanna Schiavone, Vittoria Martin

172 Scientific Report 2014 8. Appendices 173 Impressum

Copyright © Ente Ospedaliero Cantonale

Editing EOC Head Office Communication Service EOC Medical Area Simonetta Incerpi (translation/revision)

Graphic concept and layout mhi identity design consultants, Sorengo

Photos Francesco Ciriello Gianluca Chiarello Alessandro Crinari EOC Archive