Scientific Report 2014
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Scientific Report 2014 Ente Ospedaliero Cantonale Index Preface 5 4. Swiss Clinical Trial Organization 87 4.1 EOC Clinical Trial Unit (CTU-EOC) 88 1. Oncology Institute of Southern Switzerland (IOSI) 9 1.1 Medical Oncology Service 11 5. Scientific Research Advisory Board (ABREOC) 91 1.2 Radiation Oncology Service 12 1.3 Medical Physics Unit of the Radiation Oncology Service 16 6. Official Registry of the EOC clinical studies 95 1.4 Nuclear Medicine Service and PET/CT Centre 17 (EOC Database of clinical studies) 1.5 Palliative Care Service 20 1.6 Haematology Service 21 7. Publications in 2014 99 1.7 Research Division 23 Publications in peer-reviewed journals in 2014 104 1.8 IOSI Nursing Service 31 Publications in non-peer-reviewed journals in 2014 129 Communications at medical conference in 2014 130 2. Neurocenter of Southern Switzerland (NSI) 35 Publications in books in 2014 156 2.1 Multiple Sclerosis Centre 36 2.2 Sleep and Epilepsy group 39 8. Appendices 159 2.3 Movement Disorders Centre 42 Appendix 1 - Research projects funded by ABREOC in 2008 160 2.4 Stroke Centre 45 Appendix 2 - Research projects funded by ABREOC in 2009 162 2.5 Neuropsychology 46 Appendix 3 - Research projects funded by ABREOC in 2010 164 2.6 Neurosurgery 47 Appendix 4 - Research projects funded by ABREOC in 2011 168 2.7 Neuroradiology 50 Appendix 5 - Research projects funded by ABREOC in 2012 - 2013 170 2.8 Neuroanaesthesia 51 Appendix 6 - Research projects funded by ABREOC in 2014 172 2.9 Laboratory for Biomedical Neurosciences (LBN) 52 Appendix 7 - 2014 EOC Projects subject to General Authorisation (AG) 172 3. EOC Multisite Departments and Services 59 3.1 EOC Department of Surgery 60 3.2 EOC Department of Internal Medicine 64 3.3 EOC Department of Intensive Care Medicine 74 3.4 EOC Department of Laboratory Medicine 75 3.5 Paediatrics Services 76 3.6 Anaesthesiology Services 80 3.7 Dermatology and Allergology/Clinical Immunology Services 80 3.8 Geriatric Service 81 3.9 Radiology Services 82 Together for a better care Preface Preface For the EOC, the year 2014 was characterized This positive development in quality of translational Furthermore, I would like to highlight that the I would like to end by mentioning a famous quote: by a high scientific productivity. Indeed, scientific and clinical research activities, conducted within Official Registry of the EOC clinical studies has “The ultimate goal of our hard work is not the productivity of the EOC continued its upward the hospitals and Institutes of the EOC, is one been created and has been effective since April reward, it is the pleasure of making the best use of trend as per quantity and quality of its publications of the fundamental pillars within the newly- 2014 (see chapter 6). cognitive abilities belonging to Homo Sapiens. (+62% of 2011 peer-reviewed publications, see established Human Medicine Master of the Currently, 222 studies are entered into the (Lo scopo ultimo di quanto si produce non è il also charts in chapter 7), its impact factor (4% of Faculty of Biomedical Sciences of the Università Database, which will be made available on the premio, ma il piacere di utilizzare al meglio le all publications were in top-level scientific journals) della Svizzera Italiana. website www.eoc.ch by the end of 2015. capacità cognitive delle quali è dotato l'Homo and its number of clinical trials. Furthermore, the The EOC Official Registry is a very important tool to Sapiens) EOC is comparable, in number of publications Last but not least, such a growing development define strategies for further development in clinical (Rita Levi-Montalcini)”. and total impact factor, to other two important in scientific research is the best basis to ensure research of the EOC; besides, it will be essential to Cantonal Hospitals: Luzerner Kantonsspital (LUKS) that our patients increasingly receive updated and support the Human Medicine Master. and St. Gallen (KSSG). timely treatments, thanks to the prompt transfer Fabrizio Barazzoni MD MPH All this reflects the dedication and the excellence of the most recent knowledge from this sector to Finally, I wish to express my gratitude to all those FMH Prevention and Public Health Head of the Medical Area of the EOC Head Office of our scientists and clinical investigators, who patients. who contributed to a further growth in knowledge Chairman of the Scientific Research Advisory Board continue to receive high recognition at national produced by scientific research in the clinical field Bellinzona, 3rd July 2015 and international levels. However, special thanks In the various chapters included in this Scientific with great dedication, commitment and passion. should also go to the Clinical Trial Unit (CTU-EOC) Report, it is possible to follow, in more details, the This is because we are convinced that patients that promotes a culture of studies and favourable lines of research developed in the laboratories can be provided with a better healthcare quality conditions in the field of clinical research, assisting, and in all the clinical Services or Departments of in hospitals where research is actively carried out; for instance, in the process of grant writing and the EOC and to understand the deepest meaning our first goal remains to cure our patients. supporting educational programs for all those of their value. All major areas in medicine and involved in research. biology are actively developed and are covered by translational and clinical research projects. 6 Scientific Report 2014 Preface 7 1 Oncology Institute of Southern Switzerland (IOSI) 1. Oncology Institute of Southern Switzerland (IOSI) The IOSI includes all the specializations dealing with (IOR) and are run by the "Fondazione ticinese per the success achieved in 2014 in more details. achieve this result in such a short period of time. oncology within the EOC in a single organizational la ricerca e la cura dei linfomi" (Ticino Foundation In this introduction I would just like to highlight However, in the field of research nothing is won structure. The IOSI has been devised on the basis for the research and treatment of lymphomas), the decision of our regional Parliament, which forever. Therefore, the achievement of this crucial of the North American model of "comprehensive although functionally, they are part of the IOSI’s at the end of last year, decided to create a new goal should not be viewed as the end point of our cancer centres", but has its own particular research division. Biomedical Department at USI (Università della journey it is rather, a happy beginning of a new era structure, as it has a horizontal structure Svizzera Italiana), which is our University. After of growth. throughout the EOC. IOSI and Research: Balance of a Year taking this decision, now the new department has Research has always been a pivotal priority for to be practically implemented. It will encompass Prof. Franco Cavalli MD Therefore the IOSI is intended to be an all-inclusive the IOSI. Our yearly research budget with more a Medical Master School (MMS), but will also Scientific Director structure, containing all the specializations that than 8 million CHF represents about 15% of the have a second sector (biomedical research), to deal with the diagnosis, treatment and research in total budget of IOSI, a proportion that almost no which our IOR should be affiliated even before the 1.1 Medical Oncology Service the field of tumour diseases. one among the other similar cancer institution in beginning of the activity of MMS. The procedure Prof. Michele Ghielmini MD Switzerland can reach. Functionally, the Research for this affiliation is already ongoing and should Medical Director of the IOSI and Head Doctor The IOSI has six Services: medical oncology, Division of IOSI encompasses both the clinical part be concluded in the course of this year. This will radio-oncology, haematology, nuclear medicine, as well as research, which is carried out in the represent not only the ultimate recognition of the It is well known, but worthwhile to be repeated palliative care and research. Each service has its laboratories of IOR. This ensures that the clinical quality of the research activities we have been continuously, that patients are much better treated own research program coordinated by the the part and the laboratory research are closely carrying out in the last few years, but will also in health structures where research is carried IOSI Scientific Board, which decides on common connected, which is still something that many mean this is a guarantee for the long-term stability out. Indeed, the physician, who spends some of his research guidelines. The research laboratories cancer institutes in Switzerland do not have. of IOR. When we started to develop our research working time (and very often also of his free time!) of the Institute for Research in Biomedicine (IRB) I will tackle this subject later on, when I present laboratories a little over 10 years ago, we would to deal with clinical studies and research is obliged are part of the Institute of Oncology Research the activity of the research division of the IOSI, never have dreamed of being able to not only to be very updated, but also to predict the future developments in his field. 10 Scientific Report 2014 1. Oncology Institute of Southern Switzerland (IOSI) 11 Research is absolutely necessary to become a without this assessment (Dr. Ratti and Dr. Marini). The scientific activities of the Radiation-Oncology doses and fractionation schedules for ductal specialist in a specific disease within oncology. Department, with the contribution of the carcinoma in situ (DCIS) of the breast. At the IOSI there are always more organised Main funding physicians and a research nurse/data manager, Lead investigator IOSI: MC.