Amelia J. Eisch, Ph.D. Curriculum Vitae, 31 August 2019 Tenured Professor Mail address: Abramson Research Center University of Pennsylvania Perelman School of Medicine (PennMed) and Room 402F Children's Hospital of Philadelphia (CHOP) Research Institute 3615 Civic Center Blvd. Email: [email protected], [email protected], Philadelphia, PA 19104-4318 or [email protected] Physical address: 68 Osler Circle Office telephone: (215) 590-1931 Philadelphia, PA 19104

EDUCATION

Yale University, New Haven, CT 1986-1990 Bachelor of Arts in Psychology with Biology Track, cum laude

University of California at Irvine, Irvine, CA 1990-1997 Doctor of Philosophy in Biological Sciences, received June 1997 Department of Psychobiology

Yale University Medical School, New Haven, CT 1997-2000 Department of Psychiatry Postdoctoral Fellowship

RESEARCH EXPERIENCE AND EMPLOYMENT

Undergraduate Research, Advisor, Dr. Richard J. Gerrig 1988-1989 Department of Psychology, Yale University: Memory retrieval during language comprehension

Undergraduate Research, Advisor, Dr. J. Steve Reznick 1988-1989 Department of Psychology, Yale University: Shyness in infant twins

Undergraduate Honors Research Thesis, Advisor, Dr. Mark A. Riddle 1989-1990 Child Study Center, Yale University Medical Center Socioeconomic impact on symptomatology in Gilles de la Tourette’s syndrome

Doctoral Thesis, Research, and Teaching Assistant, Advisor, Dr. John F. Marshall 1990-1997 Department of Psychobiology, University of California at Irvine Neuronal consequences of repeated administration of methamphetamine

Postdoctoral Fellow, Advisor, Dr. Eric J. Nestler 08/1997-08/2000 Department of Psychiatry, Yale University Medical School Neuroadapations to drugs of abuse and antidepressants Assistant Professor, Research Track 09/2000-09/2002 Department of Psychiatry, UT Southwestern Medical Center (UTSW): Opiates and adult neurogenesis Assistant Professor, Tenure Track 10/2002-08/2009 Department of Psychiatry, UTSW: Adult neurogenesis and psychiatric and neurologic disorders Member, Integrative Biology and Neuroscience graduate programs Associate Professor with Tenure 09/2009-08/2016 Department of Psychiatry, UTSW Adjunct Faculty, UTSW: 10/2016-04/2018 Limbic circuit plasticity, dentate gyrus adult neurogenesis, and normal and pathological brain functioning Member, Integrative Biology and Neuroscience graduate programs

Member, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern 10/2015-04/2018

Tenured Professor 09/2016-present University of Pennsylvania Perelman School of Medicine Mahoney Institute of Neuroscience (09/2016-present) and Department of Neuroscience (06/2017-present) Member, Graduate Groups: Neuroscience (NGG, 09/2016-present), Pharmacology (PGG, 09/2017-present) The Children's Hospital of Philadelphia (CHOP) Department of Anesthesiology and Critical Care Medicine (09/2016-present) Research focus: Hippocampal Circuitry in Brain Health, Injury, and Disease Lab nickname: Limbic Circuitry, Mental Function, and New Neurons of the Postnatal Brain (LMNoP)

1 Eisch, Amelia J. HONORS, FELLOWSHIPS, AND AWARDS Graduate cum laude, Yale University, New Haven, CT 1990

Honors Conferred for undergraduate research thesis, Yale University, New Haven, CT 1990 “Socioeconomic impact on symptomatology in Gilles de la Tourette’s syndrome”

Summer Research Fellowship, National Science Foundation 1990 For work performed in the Department of Psychobiology, University of California, Irvine

California Reagents Tuition Fellowship, University of California, Irvine, CA 1990-1991

Steinhaus Award for Excellence in Teaching, University of California, Irvine, CA 1991

California Reagents Fellowship, University of California, Irvine, CA 1993 National Research Service Award, Institutional Predoctoral Fellowship 1993-1995 National Institute on Drug Abuse/National Institutes of Health (NIH). University of California, Irvine National Research Service Award, Individual Predoctoral Fellowship NIH/NIDA F31 DA0056471995-1997 “Processes underlying methamphetamine-induced neurotoxicity”, direct costs: $26,016/year Travel Fellowship for Meeting of the College on Problems of Drug Dependence 1996 National Institute on Drug Abuse/National Institutes of Health, total award: $1,000. San Juan, Puerto Rico National Research Service Award, Institutional Postdoctoral Fellowship 1997-1999 Department of Psychiatry, Yale University. National Institute on Drug Abuse/NIH, T32 DA 7290

Young Investigator Award, National Alliance for Research on Schizophrenia and Depression 2002-2004 “Brain-derived neurotrophic factor (BDNF) in the ventral midbrain: A role in depression”, total award: $60,000

Featured Young Investigator, National Alliance for Research on Schizophrenia and Depression 2003 Presented research on “Brain-derived neurotrophic factor and depression” at annual meeting in NY, NY

Travel Fellowship for Society for Neuroscience Meeting 2004 National Institute on Drug Abuse/National Institutes of Health, total award: $500. San Diego, CA

Co-Chair of inaugural minisymposium at annual meeting of Society for Neuroscience 2004 “New Horizons for New Neurons: Adult Neurogenesis and Psychiatry”, San Diego, CA

Young Investigator Award, National Alliance for Research on Schizophrenia and Depression 2004-2006 “Periadolescent methylphenidate and adult hippocampal neurogenesis”, total award: $60,000

Nominated as Outstanding Teacher of the Year 2005, 2007 Department of Psychiatry, UT Southwestern Medical Center

Educator of Distinction, Joseph B. Whitehead Foundation, Atlanta, GA 2006 Chapter Program Award for UT Southwestern Chapter of Sigma Xi (AJ Eisch, President) 2008 Sigma Xi, The Scientific Research Society Nominated for The University of Texas Academy of Health Science Education 2009 Honor Society and Action Group to advance the quality of education in Texas Universities

Kavli Frontiers of Science Fellow, National Academy of Sciences, USA 2010

Chair of session on Neural Stem Cells 2010 Kavli Frontiers of Science/National Academy of Sciences annual meeting, Irvine, CA

Selected as inaugural Seymour Benzer Lecturer, National Academy of Sciences 2011 Award established by Nobel Laureate Sydney Brenner to honor a researcher in neuroscience or genetics

Nominated by UTSW to apply for ELAM program (Executive Leadership in Academic Medicine) 2011

Finalist, 2012 Award for Excellence in Postdoctoral Mentoring 2012 UT Southwestern Medical Center Second place nomination, 2013 Minnie Stevens Piper Foundation Professorship 2013 UT Southwestern Medical Center

Graduate Student-Nominated 2015 Seminar Speaker 2015 Department of Biology, Drexel University, Philadelphia, PA

2 Eisch, Amelia J. Vice President 2019 Philadelphia Chapter of the Society for Neuroscience

Annual Student-Selected Speaker 2019 Neuroscience Program, University of Massachusetts Medical School, Worcester, MA

RESEARCH GRANTS ONGOING GRANTS

1) National Aeronautics and Space Administration (NASA) NNX15AE09G (UTSW) 01/30/15-07/17/17 Type: Ground-Based Study in Space Radiation 80NSSC17K0060 (CHOP) 08/01/17-07/31/20 Title: HZE particle exposure-induced improvement of pattern separation in mature mice: alterations in mission-relevant behaviors and neural circuitry Role: Principal Investigator Total direct costs: $1,058,509 (Years 1-4)

2) NIH National Institute on Stroke and Neurological Disorders (NINDS) T32NS007413 07/01/18-06/30/23 Type: Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research T32 Training Grant Title: Training Program in Neurodevelopmental Disabilities Role: co-Director (with Eric D. Marsh; PI: MB Robinson) Total direct costs: $1,923,000 (Years 21-25)

3) NIH NIMH R15 MH117628 05/17/19 - 04/30/21 Type: R15 AREA Grant Title: Deconstructing Depression Susceptibility and Emotional Resilience in Rats Role: Co-I (PI: K Lambert, University of Richmond) Total direct costs: $437,538 (Years 1-2)

4) Translational Research Institute for Space Health (TRISH) and NASA 08/01/19 - 07/31/21 Type: Postdoctoral Fellowship Cooperative Agreement NNX16AO69A Title: Effects of Galactic Cosmic Radiation on Translationally Relevant Cognitive Behaviors and Response to Social Stress Role: Postdoctoral Mentor (Trainee: Fred C. Kiffer) Total direct costs: $150,000 (Years 1-2)

PENDING GRANTS

Pennsylvania Department of Health Proposed project dates: 06/01/19-05/31/23 (awaiting decision) Type: Collaborative Research Grant Title: Individualized Guidelines for Opioid Dosing Based on Role: Co-Investigator (PI: Hakon Hakonarson) Genetic Risk and Mechanisms

NIH NIDA (due Oct 16, 2019) Proposed project dates: 07/01/20-06/30/22 Type: R21 Exploratory/Developmental Research Grant Title: Targeting memory circuits to protect Role: Principal Investigator against opioid relapse

NIH NIMH (due Feb 5, 2019) Proposed project dates: 09/01/20-08/31/25 Type: R01 Research Project Grant Title: Entorhinal cortex-dentate gyrus circuit control Role: Principal Investigator of negative valence and cognitive systems

NIH NINDS (due Feb 16, 2020) Proposed project dates: 09/01/20-03/31/22 Type: R21 Exploratory/Developmental Research Grant Title: Traumatic brain injury-induced Role: co-Principal Investigator (with Akiva Cohen) neurogenesis: friend or foe?

COMPLETED GRANTS

NIH National Institute of Mental Health (NIMH) P50 MH66172 2002-2007 Type: Silvio O. Conte Center Grant, Eric J. Nestler, Principal Investigator Title: Neural substrates of appetitive behavior in mood and motivation Role: Project Co-Leader Total direct costs to Eisch: $50,000/yr (Years 1-5) National Alliance for Research on Schizophrenia and Depression (NARSAD) 2002-2004 Type: Young Investigator Award Title: Brain-derived neurotrophic factor (BDNF) in the ventral midbrain: A role in depression Role: Principal Investigator Total direct costs: $30,000/yr (Year 1-2)

NIH National Institute of Aging (NIA) 2003-2004 Type: Pilot Grant from UT Southwestern Medical Center Alzheimer's Disease Center (NIH/NIA P30AG12300) Title: Adult neurogenesis in a mouse model of Alzheimer’s disease Role: Principal Investigator Total direct costs: $30,000/yr (Year 1) 3 Eisch, Amelia J. National Alliance for Research on Schizophrenia and Depression (NARSAD) 2004-2006 Type: Young Investigator Award Title: Periadolescent methylphenidate and adult hippocampal neurogenesis Role: Principal Investigator Total direct costs: $30,000/yr (Years 1-2) National Aeronautics and Space Administration (NASA) NNX07AP84G 09/01/07-08/31/11 Type: Ground-Based Study in Space Radiation Title: The impact of HZE particles on adult neural stem cells and neurogenesis Role: Co-Principal Investigator (w/Benjamin P. Chen). Total direct costs to Eisch: $100,000/year (Years 1-4)

NIH National Institute on Drug Abuse (NIDA) R21 DA 023701 04/01/08-03/31/10 Type: R21 Exploratory Developmental Research Grant (no cost extension through 03/31/11) Title: Cdk5 and adult hippocampal neurogenesis Role: Principal Investigator Total direct costs: $275,000 over 2 yr

Norwegian Department of Public Health (Nasjonalt Folkehelseinstitutt) 12/1/10-11/30/11 Title: Influence of methadone on adult rat hippocampal neurogenesis Role: Principal Investigator Total direct costs: $50,000/yr (Year 1) NIH National Institute of Disorders of the Kidney (NINDK) 06/01/10-05/31/11 Type: Pilot Grant from UT Southwestern O’Brien Kidney Core Research Center (NIH P30 DK079328) Title: Stem cells in the adult kidney: application of a novel transgenic mouse Role: Principal Investigator Total direct costs: $42,145/yr (Year 1)

National Alliance for Research on Schizophrenia and Depression (NARSAD) 09/01/10-09/14/12 Type: Independent Investigator Award Title: Adult neurogenesis and stress-induced social avoidance Role: Principal Investigator Total direct costs: $50,000/yr (Years 1-2)

NIH National Institute on Drug Abuse (NIDA) R01 DA 016765-07S1 09/29/10-09/28/11 Type: R01 Research Project Grant Supplement (ARRA) Title: Opiates and adult neurogenesis Role: Principal Investigator Total direct costs: $150,000/yr (Year 1) NIH National Institute on Drug Abuse (NIDA) R01 DA 016765 07/01/03-01/31/15 Type: R01 Research Project Grant Title: Opiates and adult neurogenesis Total direct costs: $200,000/yr (Years 1-5) Role: Principal Investigator $225,000/yr (Years 6-end)

National Aeronautics and Space Administration (NASA) NNX12AB55G 11/10/11-11/09/15 Type: Ground-Based Study in Space Radiation Title: Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior Role: Principal Investigator Total direct costs: ~$283,000/yr (Years 1-3), $182,400 (Year 4)

NIH National Institute on Drug Abuse (NIDA) T32 DA 007290-21 07/01/08-05/31/16* Type: Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research T32 Training Grant Title: Basic Science Training Program in Drug Abuse Research Role: Principal Investigator (2008-present) Total direct costs: $462,102/yr (Years 21-25) Supported 6 predoctoral and 5 postdoctoral researchers in research on basic neuroscience of addiction in T32 faculty member laboratories at UT Southwestern Medical Center. *Note: When I moved to PennMed/CHOP in Fall 2016, I transferred this to David W. Self (UTSW) June 1, 2016. Actual end date is 06/30/18. NIH National Institute of Mental Health (NIMH) 1R25MH101078 07/01/14-06/30/19 Type: R25 Title: Translational Research Activities in Neuropsychiatry (TRAIN) Role: Basic Science Liaison, 5% (PI, Madhukar Trivedi) Total direct costs: $250,000/yr (5% to Eisch) *Note: As I moved to PennMed/CHOP in Fall 2016, I resigned from this grant application effective August 30, 2016. Actual end date of grant was 06/30/19.

NIH National Institute of Mental Health (NIMH) R21MH107945 08/15/15-06/30/17 (NCE to 06/30/18) Type: R21 Research Project Grant Title: Molecular and chemogenetic control of dentate gyrus inputs: Role: Principal Investigator a novel approach to combat depression-like behavior

NIH National Institute on Drug Abuse (NIDA) K02DA023555 08/01/07-12/31/17 (NCE until 12/31/18) Type: K02 Independent Scientist Award (Renewal) Title: New Horizons in Adult Neurogenesis Role: Principal Investigator Total direct costs: ~$111,438/yr (Years 6-10) 4 Eisch, Amelia J. PUBLICATIONS

116 total: 82 Peer-reviewed Research Papers 1 Non-peer-reviewed Research Paper 33 Peer-reviewed Reviews Also shown below: 2 Books or Journal Issues Edited 5 Media Communications Citations indices (www.googlescholar.com) for AJ Eisch as of 31 August 2019: total citations: 19479 citations since 2014: 8837 h-index: 61 h-index since 2014: 44 i10-index: 98 i10-index since 2014: 92

Complete List of Published Work in MyBibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/amelia.eisch.1/bibliography/40778882/public/?sort=date&direction=as cending

PEER-REVIEWED RESEARCH PAPERS (82 total)

1) Eisch AJ, Gaffney M, Weihmuller FB, O'Dell SJ, Marshall JF. Striatal subregions are differentially vulnerable to the neurotoxic effects of methamphetamine. Brain Research. 598:321-326 (1992). PMID 1486494. Cited over 100 times 2) Eisch AJ, O'Dell SJ, Marshall JF. Striatal and cortical NMDA receptors are altered by a neurotoxic regimen of methamphetamine. Synapse. 22:217-225 (1996). PMID 9132989. Cited over 100 times 3) Eisch AJ, Schmued LC, Marshall JF. Characterization of cortical Fluoro-Jade labeling after a neurotoxic regimen of methamphetamine. Synapse. 30:329-333 (1997). PMID 9776136. Cited over 100 times 4) Eisch AJ and Marshall JF. Methamphetamine neurotoxicity: Dissociation of striatal dopamine terminal damage from parietal cortical cell body injury. Synapse. 30:433-445 (1998). PMID 9826235. Cited over 100 times 5) Eisch AJ, Lammers C-H, Yajima S, Mouradian MM, Nestler EJ. In vivo regulation of glial-derived neurotrophic factor-inducible transcription factor (GIF) by kainic acid. Neuroscience. 94:629-636 (1999). PMID 10579223. 6) Messer CJ, Eisch AJ, Carlezon WA, Whisler K, Shen L, Wolf DH, Westphal H, Collins F, Russell DS, Nestler EJ. Role for GDNF in biochemical and behavioral adaptations to drugs of abuse. Neuron. 26:1-20 (2000). PMID 10798408. Cited over 100 times 7) Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ. Opiates inhibit neurogenesis in the adult rodent dentate gyrus. Proceedings of the National Academy of Sciences, USA. 97:7579-7584 (2000). PMID 10840056, PMC 16588. Cited over 600 times 8) Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Antidepressant treatment increases the birth and survival of neurons in the adult rat hippocampus. Journal of Neuroscience. 20:9104-9110 (2000). PMID 11124987. Cited over 3000 times 9) Monteggia LM, Eisch AJ, Tang MD, Kaczmarek LK, Nestler EJ. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Molecular Brain Research. 81:129-139 (2000). PMID 11000485. Cited over 100 times 10) Chen ACH, Eisch AJ, Sakai N, Takahashi M, Nestler EJ, Duman RS. Regulation of GFRalpha-1 and GFRalpha-2 mRNAs in rat brain by electroconvulsive seizure. Synapse. 39:42-50 (2001). PMID 11071708. 11) Hwang CK, D'Souza UM, Eisch AJ, Yajima S, Lammers CH, Yang Y, Lee SH, Kim YM, Nestler EJ,

5 Eisch, Amelia J. Mouradian MM. Dopamine receptor regulating factor, DRRF: A zinc finger transcription factor. Proceedings of the National Academy of Sciences, USA. 98:7558-7563 (2001). PMID 11390978, PMC 34707. 12) Barrot MB, Olivier JDA, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC, Zachariou V, Nestler EJ. CREB activity in the nucleus accumbens shell control gating of behavioral responses to emotional stimuli. Proceedings of the National Academy of Sciences, USA. 99:11435-11440 (2002). PMID 12165570, PMC 123274. Cited over 500 times 13) Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ, DiLeone RJ. Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. Journal of Neuroscience, 23:3106-3111 (2003). PMID 12716916. Cited over 300 times 14) Bolaños CA, Perrotti LI, Edwards S, Eisch AJ, Barrot M, Olson VG, Russell DS, Neve RL, Nestler EJ. Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood- related behaviors. Journal of Neuroscience, 20:7569-7576 (2003). PMID 12930795. 15) Eisch AJ, Bolaños CA, Wit J, Simonak RD, Pudiak CM, Barrot M, Verhaagen J, Nestler EJ. BDNF in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biological Psychiatry, 54:994-1005 (2003). PMID 14625141. Cited over 400 times 16) Mandyam CD, Norris R, Eisch, AJ. Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone. Journal of Neuroscience Research. 76:783-794 (2004). PMID 15160390. Cited over 100 times 17) Beech RD, Cleary MA, Treloar HB, Eisch AJ, Harrist AV, Zhong W, Greer CA, Duman RS, Picciotto MR. Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neuron. Journal of Comparative Neurology. 475:128-141 (2004). PMID 15176089. 18) Harrist A, Beech RD, King SL, Zanardi A, Cleary MA, Caldarone BJ, Eisch AJ, Zoli M, Picciotto MR. Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptor. Synapse. 54:200-206 (2004). PMID 15472930. 19) Waugh JL, Lou AC, Eisch AJ, Monteggia LM, Muly EC, Gold SJ. Regional, cellular, and subcellular localization of RGS10 in rodent brain. Journal of Comparative Neurology. 481:299-313 (2005). PMID 15593368. 20) Olson VG, Zabetian CP, Barrot M, Eisch AJ, Hughes T, Neve RL, Nestler EJ. Regulation of Drug Reward by CREB: Evidence for Two Functionally Distinct Subregions of the Ventral Tegmental Area. Journal of Neuroscience. 25:5553-5562 (2005). PMID 15944383. Cited over 100 times 21) D’Sa C, Eisch AJ, Bolger GB, Duman RS. Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration. European Journal of Neuroscience. 22:1463-1475 (2005). PMID 16190900. 22) Donovan MD, Yazdani O, Norris RD, Games RD, German DC, Eisch AJ. Decreased adult hippocampal neurogenesis and granule cell number in the PDAPP mouse model of Alzheimer’s Disease. Journal of Comparative Neurology. 495:70-83 (2006). PMID 16432899. Cited over 300 times 23) Lagace DC, Yee JK, Bolaños CA, Eisch AJ. Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesis. Biological Psychiatry. 60:1121-1130 (2006). PMID 16893528. 24) Harburg GC, Hall FS, Harrist AV, Sora I, Uhl GR, Eisch AJ. Knockout of the mu opioid receptor enhances survival of adult-generated hippocampal granule cell neurons. Neuroscience. 144:77-87 (2006). PMID 17055658, PMC 2230097. 25) Russo SJ, Bolaños CA, Theobald DE, Decarolis N, Kumar A, Renthal NE, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ. IRS-2-Akt in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates. Nature Neuroscience. 10:93-99 (2007). PMID 17143271. Comment in Nature Neuroscience. 10(1):9-10 (2007) Recommended article, Faculty of 1000 Biology

6 Eisch, Amelia J. Cited over 100 times 26) Battiste J, Helms AW, Lagace DC, Kim E, Mandyam CD, Eisch AJ, Johnson JE. Ascl1 defines sequentially generated lineage restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development. 134:285-293 (2007). PMID 17166924. Cited over 100 times 27) Lagace DC, Fischer SJ, Eisch AJ. Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in mice. Hippocampus. 17:175-180 (2007). PMID 17286277. Cited over 100 times 28) Mandyam CD, Harburg GC and Eisch AJ. Determination of key technical aspects of precursor detection and division in the adult mouse subgranular zone. Neuroscience. 146:108-122 (2007). PMID 17307295, PMC 2230096. Cited over 100 times 29) Ongur D, Pohlman J, Eisch AJ, Patel TB, Edwin F, Heckers S, Cohen BM, Carlezon Jr., WA. Electroconvulsive seizures stimulate cellular proliferation and reduce expression of Sprouty within the prefrontal cortex of rats. Biological Psychiatry. 62:505-512 (2007). PMID 17336937. 30) Mandyam CD, Wee S. Eisch AJ, Richardson HN, Koob GF. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. The Journal of Neuroscience. 27(42):11442–11450 (2007). PMID 17942739, PMC 2741502. Cited over 100 times 31) Krishnan V, Han M-H, Graham D, Berton O, Renthal W, Laplant Q, Graham A, Russo S, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green T, Neve R, Chakravarty S, Eisch AJ, Self DW, Lee F, Tamminga C, Cooper D, Gershenfeld H, Nestler EJ Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 131:391-404 (2007). PMID 17956738. Comment in Cell 131(2):232-4 Oct 19 (2007) Recommended article, Faculty of 1000 Biology Exceptional article, Faculty of 1000 Medicine Cited over 1300 times 32) Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, Dileone RJ, Greer CA, Mandyam CD, Eisch AJ. Dynamic contribution of nestin- expressing stem cells to adult neurogenesis. The Journal of Neuroscience. 27:12623–12629 (2007). PMID 18003841, PMC 2587597. Recommended article, Faculty of 1000 Biology Cited over 300 times 33) Fischer SJ, Arguello AA, Charlton JJ, Fuller DC, Zachariou V, Eisch AJ. Morphine dependence and regulation of subgranular zone proliferation relies on administration paradigm. Neuroscience. 151:1217- 1224 (2007). PMID 18248906. 34) Donovan MH, Yamaguchi M, Eisch AJ. Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus. Hippocampus. 18:435-439 (2008). PMID 18240316, PMC 2553009. 35) Mandyam CD, Crawford E, Lee S, Eisch AJ, Rivier CL and Richardson HN. Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus. Developmental Neurobiology. 68(5):575-589 (2008). PMID 18264994, PMC 3679899. 36) Noonan MA, Choi K-H, Self DW, Eisch AJ. Withdrawal from cocaine self-administration enhances hippocampal neurogenesis, but normalizes proliferation and maturation of neural progenitors, in the adult dentate gyrus subgranular zone. The Journal of Neuroscience. 28:2516-2526 (2008). PMID 18322096. Recommended article, Faculty of 1000 Biology Cited over 100 times 37) Krishnan V, Graham A, Mazei-Robison MS, Lagace DC, Kim KS, Birnbaum S, Eisch AJ, Han PL, Storm DR, Zachariou V, Nestler EJ. Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting. Biological Psychiatry. 64(4):336-343 (2008). PMID 18468583, PMC 2580057. 38) Mandyam CD, Wee S, Crawford EF, Eisch AJ, Richardson HN, Koob GF. Varied access to intravenous

7 Eisch, Amelia J. methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biological Psychiatry. 64(11):958-965 (2008). PMID 18490002, PMC 2587157. Cited over 100 times 39) Krishnan V, Han MH, Mazei-Robison M, Iñiguez SD, Ables JL, Vialou V, Berton O, Ghose S, Covington HE 3rd, Wiley MD, Henderson RP, Neve RL, Eisch AJ, Tamminga CA, Russo SJ, Bolaños CA, Nestler EJ. AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biological Psychiatry. 64(8):691-700 (2008). PMID 18639865, PMC 2742561. Cited over 100 times 40) de Chevigny A, Cooper O, Vinuela A, Reske-Nielsen C, Lagace DC, Eisch AJ, Isascon O. Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after TGFalpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells. 26(9):2349-2360 (2008). PMID 18556510, PMC 2649803. 41) Arguello AA, Harburg GC, Schonborn JR, Mandyam CD, Yamaguchi M, Eisch AJ. Time course of morphine’s effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons. Neuroscience, 157(1):70-79 (2008). PMID 18832014, PMC 2694451. 42) Lagace DC, Benavides DR, Kansy JW, Musacchio A, Greengard P, Bibb JA, Eisch AJ. Cdk5 is essential for adult hippocampal neurogenesis. Proceedings of the National Academy of Sciences, USA. 105(47):18567-18571 (2008). PMID 19017796, PMC 2587597. Cited over 100 times 43) Arguello AA, Fischer SJ, Schonborn JR, Markus RW, Brekken RA, Eisch AJ. Effect of chronic morphine on the dentate gyrus neurogenic microenvironment. Neuroscience. 159(3):1003-1010 (2009). PMID 19356684, PMC 2694451. 44) Gao Z, Ure K, Ables JL, Lagace DC, Nave K-A, Goebbels S, Eisch AJ, Hsieh J. NeuroD1 is essential for the survival and maturation of adultborn neurons. Nature Neuroscience, 12(9):1090-1092 (2009). PMID 19701197, PMC 3365543. Commented on in Nature Neuroscience Sep;12(9):1079-81 (2009) Recommended article, Faculty of 1000 Biology Cited over 300 times 45) Coremans V, Ahmed T, Balschun D, D’Hooge R, De Vriese A, Cremer J, Antonucci F, Moons M, Baekelandt V, Reumers V, Cremer H, Eisch AJ, Lagace DC, Janssens T, Bozzi Y, Caleo M, Conway EM. Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin. BMC Neuroscience, 11(2):1-19 (2010). PMID 20051123, PMC 2817683. 46) Noonan MA, Bulin SE, Fuller D, Eisch AJ. Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of addiction. The Journal of Neuroscience, 30(1):304-315 (2010). PMID 20053911, PMC 2844797. Featured in Nature, Research Highlights, 1/14/10 doi:10.1038/463138b Cited over 100 times 47) Lagace DC, Donovan MH, Farnbauch LA, DeCarolis NA, Berton O, Nestler EJ, Krishnan V, Eisch AJ. Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance. Proceedings of the National Academy of Sciences, USA. 107(9):4436-4441 (2010). PMID 20176946, PMC 2840117. Cited over 200 times 48) Li L, Harms KH, Ventura PB, Lagace DC, Eisch AJ, Cunningham LA. Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic. Glia, 58(13):1610-1619 (2010). PMID 20578055, PMC 2919586. Cited over 100 times 49) Ables JL, DeCarolis NA, Johnson MA, Rivera PD, Gao Z, Cooper DC, Radtke F, Hsieh J, Eisch AJ. Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells. The Journal of Neuroscience, 30(31):10484-10492 (2010). PMID 20685991, PMC 2935844. Recommended article, Faculty of 1000 Biology Cited over 250 times 50) Zaccaria KJ, Lagace DC, Eisch AJ, McCasland JS. Autistic-like behavioral phenotype in GAP43

8 Eisch, Amelia J. deficient mice. Genes, Brains, and Behavior, 2010 9(8):985-996 (2010). PMID 20707874, PMC 2975747. 51) LaPlant Q, Vialou V, Covington III HE, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolaños CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature Neuroscience. 13(9):1137-1143 (2010). PMID 20729844, PMC 2928863. Commented on in Nature Neuroscience 13(9):1041-3 (2010) Cited over 400 times 52) Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han M-H, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, Kim Y, Morrison JH, Russo SJ.. IkappaB kinase regulates social defeat stress induced synaptic and behavioral plasticity. The Journal of Neuroscience. 31(1):314-321 (2011). PMID 21209217, PMC 3219041. Cited over 200 times 53) Blundell J, Blaiss CA, Lagace DC, Eisch AJ, Powell CM. Block of glucocorticoid synthesis during re- activation inhibits extinction of an established fear memory. Neurobiology of Learning and Memory, 95(4): 453-460 (2011). PMID 21333745, PMC 3356929. 54) Kim EJ, Ables JL, Dickel LK, Eisch AJ, Johnson JE. Ascl1 (Mash1) defines cells with long-term neurogenic potential in subgranular and subventricular zones in adult mouse brain. PLoS One, 6(3, e18472):1-6 (2011). PMID 21483754, PMC 3069117. Cited over 100 times 55) Guo W, Allan AM, Zong R, Zhang L, Johnson EB, Schaller EG, Murthy AC, Goggin SL, Eisch AJ, Oostra BA, Nelson DL, Jin P, Zhao X. Ablation of FMRP in adult neural stem cells disrupts hippocampal-dependent learning. Nature Medicine, 17(5):559-565. (2011). PMID 21516088, PMC 3140952. Cited over 100 times 56) Choi KH, Edwards S, Graham D, Larson E, Whisler/Edwards K, Simmons D, Friedman A, Walsh J, Rahman Z, Monteggia LM, Eisch AJ, Neve R, Nestler EJ, Han MH, Self DW. Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. The Journal of Neuroscience. 31(21):7927-7937 (2011). PMID 21613507, PMC 3103081. 57) Speed HE, Blaiss CA, Kim A, Haws ME, Melvin NR, Jennings M, Eisch AJ, Powell CM. Delayed reduction of hippocampal synaptic transmission and spines following exposure to repeated, subclinical doses of organophosphorus pesticide in adult mice. Toxicological Sciences. 125(1):196-208 (2012). PMID 21948870, PMC 3247802. 58) Sankararaman A, Masiulis I*, Richardson DR*, Andersen JM, Mørland J, Eisch AJ. Methadone does not alter key parameters of adult hippocampal neurogenesis in the heroin-naïve rat. Neuroscience Letters. 516(1):99-104 (2012). PMID 22487733, PMC not applicable (not NIH funded). *equal contribution 59) Petrik D, Jiang Y, Birnbaum SG, Powell CM, Kim M-S, Hsieh J^, Eisch AJ^. Functional and mechanistic exploration of an adult neurogenesis-promoting small-molecule. The Journal of the Federation of American Societies for Experimental Biology (The FASEB Journal). 26(8):3148-3162 (2012). PMID 22542682, PMC 3405259. ^co-corresponding authors 60) Teixeira CM, Kron MM, Masachs N, Zhang H, Lagace DC, Martinez A, Reillo I, Duan X, Bosch C, Pujadas L, Brunso L, Song H, Eisch AJ, Borrell V, Howell BW, Parent JM, Soriano E. Cell-autonomous inactivation of the Reelin pathway impairs adult neurogenesis in the hippocampus. The Journal of Neuroscience. 32(35):12051-12065 (2012). PMID 22933789, PMC 3475414. 61) Decarolis NA, Mechanic M, Petrik D, Carlton AF, Malhotra S, Ables JL, Bachoo R, Lagace DC, Eisch AJ. In vivo contribution of nestin- and GLAST-lineage cells to adult hippocampal neurogenesis. Hippocampus. 23: 708–719 (2013). PMID 23554226, PMC 3718551. 62) Petrik D, Yun S*, Latchney SE*, Kamrudin S, LeBlanc JA, Bibb JA, Eisch AJ. Early postnatal in vivo gliogenesis from nestin-lineage progenitors requires Cdk5. PLoS One, 8(8, e72819):1-11 (2013). PMID 23991155, PMC 3753242. *equal contribution 63) Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, 9 Eisch, Amelia J. Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch AJ, Metzger D, Crabtree G, Irmler M, Poot R, Götz M. The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. Cell Stem Cell. 13(4):403-418 (2013). PMID 23933087, PMC 4098720. Cited over 100 times 64) Rivera PD*, Shih H-Y*, LeBlanc JA, Cole MG, Amaral WZ, Mukherjee S, Zhang S, Lucero MJ, DeCarolis NA, Chen BPC, Eisch AJ. Acute and fractionated exposure to high-LET 56Fe HZE particle radiation both result in similar long-term deficits in adult hippocampal neurogenesis. Radiation Research. 180(6):658-667 (2013). PMID 24320054, PMC 3930069. *equal contribution 65) Latchney SE, Masiulis I, Zaccaria KJ, Lagace DC, Powell CM, McCasland JS, Eisch AJ. Developmental and adult GAP-43 deficiency in mice dynamically alters hippocampal neurogenesis and mossy fiber volume. Developmental Neuroscience. 36(1):44-63 (2014). PMID 24576816, PMC 4035301. 66) Latchney SE, Rivera PD, Mao XW, Ferguson VL, Bateman TA, Stodieck LS, Nelson GA, Eisch AJ. The effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment. Journal of Applied Physiology. Jun 15;116(12):1593-1604 (2014). PMID 24744382, PMC 4152162. 67) Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Molecular Psychiatry. 20(4): 500-508 (2014). PMID 24751964, PMC 4206684. Cited over 100 times 68) DeCarolis NA*, Rivera PD*, Ahn HF, Shih H-Y, Amaral WZ, LeBlanc JA, Malhotra S, Mukherjee S, Chen BPC, Eisch AJ. 56Fe particle exposure results in long-lasting genomic instability and transiently suppresses adult hippocampal neurogenesis in vivo. Life Sciences in Space Research. 2:70-79 (2014). PMID 25170435, PMC 4142527. *equal contribution, listed alphabetically 69) Rivera PD, Raghavan RK, Yun S, Latchney SE, McGovern M-K, Birnbaum SG, Eisch AJ. Retrieval of morphine-associated context induces cFos in dentate gyrus neurons. Hippocampus. 25(4):409-414 (2014). PMID 25424867, PMC 436845. 70) Latchney SE, Jaramillo TC, Rivera PD, Espinosa-Bacerra F, Eisch AJ^, Powell CM^. Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neuroscience Letters. 591:86-92 (2015). PMID 25668489, PMC 4363293. ^co-corresponding authors 71) Cho K-O, Ito N*, Lybrand Z*, Brulet R, Zhang L, Good L, Ure K, Nave K-A, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J. Aberrant hippocampal neurogenesis drives epilepsy and associated cognitive decline. Nature Communications. 6:1-13 (2015). PMID 25808087, PMC 4375780. *equal contribution Cited over 100 times 72) Latchney SE*, Jiang Y*, Petrik DP, Eisch AJ^, Hsieh J^. Inducible knockout of Mef2A/C/D from nestin- expressing stem/progentior cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo. The Journal of the Federation of American Societies for Experimental Biology (The FASEB Journal). 29(12):5059-5071 (2015). PMID 26286136, PMC 4653059. *equal contribution ^co-corresponding authors 73) Petrik D, Latchney SE*, Masiulis I*, Yun S*, Zhang Z*, Wu JI^, Eisch AJ^. Chromatin remodeling factor Brg1 supports the early maintenance and late responsiveness of nestin-lineage adult neural stem and progenitor cells. Stem Cells. 33(12):3655-3665 (2015). PMID 26418130, PMC 4713255. *equal contribution, listed alphabetically ^co-corresponding authors 74) Yun S, Donovan MH, Ross MN, Richardson DR, Reister R, Farnbauch LA, Fisher SJ, Riethmacher D, Gershenfeld HK, Lagace DC^, Eisch AJ^. Stress-Induced Anxiety- and Depressive-Like Phenotype Associated with Transient Reduction in Neurogenesis in Adult Nestin-CreERT2/Diphtheria Toxin Fragment A 10 Eisch, Amelia J. Transgenic Mice. PLoS One 11(1):e0147256 (2016). PMID 26795203, PMC 4721672. ^co-corresponding authors 75) Bulin SE, Mendoza ML, Richardson DR, Song KH, Solberg TD, Yun S, Eisch AJ. Dentate Gyrus Neurogenesis Ablation via Cranial Irradiation Enhances Morphine Self-administration and Locomotor Sensitization. Addiction Biology. 23(2):665-675 (2017). PMID 27198520, PMC 5775053. 76) Celen C, Chuang J-C, Luo X, Walker AK, Nijem N, Chung A, Nguyen LH, Nassour I, Budhipramono A, Sun X, Zhang S, Bok LA, McEntagart M, Gevers E, Birnbaum SG, Eisch AJ, Santen G.W.E., Chahrour M, Zhu H. Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. eLife, 11(6). pii: e25730 (2017). PMID 28695822, PMC 5515576. 77) Whoolery CW, Walker AK, Lucero MJ, Richardson DR, Reynolds RP, Beddow DH, Clark KL, Shih H-Y, LeBlanc JA, Cole MG, Amaral WZ, Mukherjee S, Zhang S, Ahn F, Bulin SE, DeCarolis NA, Rivera PD, Chen BPC, Yun S, Eisch AJ. Whole Body Exposure to 28Si Radiation Dose-Dependently Disrupts Dentate Gyrus Neurogenesis and Proliferation in the Short-Term and New Neuron Survival and Contextual Fear Conditioning in the Long-Term. Radiation Research, 188(5):532-551 (2017). PMID 28945526, PMC 5901735. 78) Ochoa Escamilla C*, Filonova I*, Walker AK, Xuan Z, Holehonnur R, Espinosa F, Liu S, Thyme SB, Lopez-Garcia IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM. Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature, 9;551(7679):227- 231 (2017). PMID 29088697, PMC 5787033. *equal contribution 79) Yun S, Reynolds RP, Petrof I, White A. Rivera PD, Segev A, Gibson AD, Suarez M, Desalle MJ, Ito N, Mukherjee S, Richardson DR, Kang CE, Ahrens-Nicklas RC, Soler I, Chetkovich DM, Kourrich S, Coulter DA, Eisch AJ. Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive. Nature Medicine, 24(5):658-666 (2018). PMID 29662202, PMC 5948139. 80) Zanni G*, Deutsch HM*, Rivera PD, Shih H-Y, LeBlanc JA, Amaral WZ, Lucero MJ, Redfield RL, DeSalle MJ, Chen BPC, Whoolery CW, Reynolds RP, Yun S, Eisch AJ. Whole-body 12C irradiation transiently decreases mouse hippocampal dentate gyrus proliferation and immature neuron number, but does not change new neuron survival rate. International Journal of Molecular Sciences, 19(10), pii:E3078. doi:10.3390/ijms19103078. (2018) PMID 30304778, PMC 6213859. *equal contribution 81) Rivera PD, Simmons SJ, Reynolds RP, Just AL, Birnbaum SG, Eisch AJ. Image-guided cranial irradiation-induced ablation of dentate gyrus neurogenesis impairs extinction of recent morphine reward memories. Hippocampus. Feb 18. doi: 10.1002/hipo.23071. (2019) PMID 30779299, PMC in progress. 82) Snitow ME, Zanni G, Ciesielski B, Burgess-Jones P, Eisch AJ, O’Brien WT, Klein PS. Adult hippocampal neurogenesis is not necessary for the response to lithium in the forced swim test. Neuroscience. Mar 30; 704: 67-72. doi: 10.1016/j.neulet.2019.03.052. (2019) PMID 30940476, PMC 6594907.

NON-PEER-REVIEWED RESEARCH PAPERS (1 total) 1) Zanni G, Featherstone BS, DeSalle MJ, Deutsch HM, Barr GA*, Eisch AJ*. Development and validation of a novel oral oxycodone self-administration protocol for female and male rats. bioRxiv 690735 doi: https://doi.org/10.1101/690735 *co-corresponding authors

PEER-REVIEWED REVIEW PAPERS, CHAPTERS, BOOKS, AND WEB CONTRIBUTIONS (33 total) 1) Nestler EJ, Barrot M, DiLeone R, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of Depression. Neuron. 34:13-25 (2002). PMID 11931738. Cited over 3000 times 2) Eisch AJ. Adult neurogenesis: implications for neuropsychiatry. Progress in Brain Research. 138:317- 344 (2002). PMID 12432777. Cited over 100 times 3) Eisch AJ and Nestler EJ. To be or not to be: Adult neurogenesis and psychiatry. Clinical Neuroscience Research. 2:93-108 (2002). 4) Eisch AJ and Mandyam CD. Drug dependence and addiction, II: Adult neurogenesis and drug abuse. American Journal of Psychiatry. 161:426 (2004). PMID 14992964. 11 Eisch, Amelia J. 5) Eisch AJ and Mandyam CD. Beyond BrdU: Basic and clinical implications for analysis of endogenous cell cycle proteins. In Focus on Stem Cell Research, EV Greer (Ed.), Nova Scientific. 111-142 (2004). 6) German DC and Eisch AJ. Mouse models of Alzheimer's disease: Insight into treatment. Reviews in the Neurosciences. 15:353-369 (2004). PMID 15575491. Cited over 100 times 7) Thome J and Eisch AJ. Neurogenesis: Relevance for pathophysiology and pharmacotherapy of psychiatric disorders (language: German). Nervenarzt. 76:11-19 (2005). PMID 15316619. 8) Eisch AJ. The involvement of brain-derived neurotrophic factor in memory and depression. McGraw-Hill Education Yearbook of Science and Technology. McGraw-Hill Press, New York. (2005). 9) Eisch AJ and Mandyam CD. Adult neurogenesis and CNS cell cycle analysis: Novel tools for exploration of the neural causes and correlates of psychiatric disorders. In Cell Cycle in the Central Nervous System. D Janigro (Ed.), Humana Press, New York. (2005). 10) Lagace DC and Eisch AJ. Mood stabilizing drugs: Are their neuroprotective aspects clinically relevant? Psychiatric Clinics of North America. 28:399-414 (2005). PMID 15826739. 11) Eisch AJ. Common neural adaptations and bidirectional influences of stress and addiction: Recent insights from basic research. Journal of Dual Diagnosis. 1:25-46 (2005). 12) Eisch AJ and Harburg GC. Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology. Hippocampus. 16:271-286 (2006). PMID 16411230. Cited over 100 times 13) Noonan MA and Eisch AJ. In vivo regulation of neural progenitors by cannabinoids. Chemistry Today. 24:28-32 (2006). 14) Lagace DC, Noonan MA, Eisch AJ. Hippocampal neurogenesis: a matter of survival. American Journal of Psychiatry. 164:205 (2007). PMID 17267780. 15) Eisch AJ and Mandyam CD. Adult neural progenitors: Can analysis of endogenous cell cycle proteins move us “beyond BrdU”? Current Pharmaceutical Biotechnology. 8:147-165 (2007). PMID 17584088. 16) DeCarolis NA, Wharton KA, Eisch AJ. Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging. BioEssays. 30:102-106 (2008). PMID 18200563. 17) Eisch AJ, Cameron HA, Encinas JM, Meltzer LA, Ming G-L, Wadiche-Overstreet LS. Adult neurogenesis, mental health, and mental illness: Hope or hype? The Journal of Neuroscience. 28(46): 11785-11791 (2008). PMID 19005040, PMC 2793333. Cited over 200 times 18) Johnson MA, Ables JL, Eisch AJ. Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches. BMB Reports. 42(5):245-259 (2009). PMID 19470237, PMC3601036. 19) Jessberger S^, Gage FH^, Eisch AJ^, Lagace DC^. Making a neuron: Cdk5 in embryonic and adult neurogenesis. Trends in Neuroscience. 32(11):575-582 (2009). PMID 19782409, PMC 2767479. ^co-corresponding authors 20) DeCarolis NA and Eisch AJ. Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation. Neuropharmacology. 58(6):884-93 (2010). PMID 20060007, PMC 2839019. Cited over 200 times 21) Hsieh J and Eisch AJ. Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiology of Aging. 39(1):73-84 (2010). PMID 20114075, PMC 2874108. Cited over 100 times 22) Ables JL, Breunig JJ, Eisch AJ^, Rakic P^. Not(ch) Just Development: Notch signaling in the Adult Brain. Nature Reviews Neuroscience. 12(5):269-283 (2011). PMID 21505516, PMC 3159580. ^co-corresponding authors Feature article, Nature Reviews Neuroscience Cited over 300 times 23) Bulin SE, Sankararaman A, Eisch AJ. Psychostimulants, opiates, and adult hippocampal neurogenesis. In Drug Addiction and Adult Neurogenesis. MF Olive (Ed.), Research Signpost/Transworld Research Network Publishers, Karala, India (2011). 24) Masiulis I, Yun S, Eisch AJ. The interesting interplay between interneurons and adult hippocampal 12 Eisch, Amelia J. neurogenesis. Molecular Neurobiology. 44(3):287-302 (2011). PMID 21956642, PMC 3756898. 25) Petrik D, Lagace DC, Eisch AJ. The neurogenesis hypothesis of affective and anxiety disorders: are we mistaking the scaffolding for the building? Neuropharmacology. 62(1):21-34 (2012). PMID 21945290, PMC 3698048. Cited over 200 times 26) Latchney SE and Eisch AJ. Therapeutic application of neural stem cells and adult neurogenesis for neurodegenerative disorders: regeneration and beyond. European Journal of Neurodegenerative Diseases. 1(3):335-351 (2012). PMID 25729743, PMC 4340249. 27) Eisch AJ and Petrik D. Neurogenesis and depression: a road to remission? Science. 338 (6103):72-75 (2012). PMID 23042885, PMC 3756889. Cited over 300 times 28) Bulin SE, Masiulis I, Rivera PD, Eisch AJ. Addiction, Hippocampal Neurogenesis, and Neuroplasticity in the Adult Brain. In Biological Research on Addiction: Comprehensive Addictive Behaviors and Disorders. Editor PG Miller. Elsevier Inc., San Diego: Academic Press, pp. 291-303 (2013). 29) Kuhn HG, Eisch AJ, Spalding K, Peterson DA. Detection and Phenotypic Characterization of Adult Neurogenesis. In Adult Neurogenesis, 2nd Edition. Editors: Gage FH, Kempermann G, Song HJ. Cold Spring Harbor Press. 8(3):a025981. (2016). 30) Norbury JW, Schimmerling W, Slaba TC, Azzam E, Badavi FF, Baiocco G, Benton E, Bindi V, Blakely EA, Blattnig SR, Boothman DA, Borak1 TB, Britten RA, Curtis S, Dingfelder M, Durante M, Dynan W, Eisch AJ, Elgart SR, Goodhead DT, Guida PM, Heilbronn LH, Hellweg CE, Huff JL, Kronenberg A, La Tessa C, Lowenstein D, Miller J, Morita T, Narici L, Nelson GA, Norman RB, Ohnishi T, Ottolenghi A, Patel ZS, Reitz G, Adam Rusek A, Schreurs A-S, Scott-Carnell LA, Semones E, Shay JW, Shurshakov VA, Sihver L, Simonsen LC, Story M, Turker MS, Uchihori Y, Williams J, Zeitlin CJ. Galactic cosmic ray simulation at the NASA Space Radiation Laboratory. Life Sciences in Space Research, 8:38-51 (2016). PMID 26948012, PMC 5771487. 31) Mendoza ML, Anderson EM, Kourrich S, Eisch AJ. A NAc for Spinal Adjustments After Cocaine And Stress. Biological Psychiatry, 79(11):872–874 (2016). PMID 27198520, PMC 5784216. 32) Yun S, Reynolds RP, Masiulis I, Eisch AJ. Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis. Nature Medicine, 22(11):1239-1247 (2016). PMID 27783068, PMC 5791154. 33) Lambert K, Eisch AJ, Galea, L, Kempermann G, Merzenich M. Optimizing brain performance: Identifying mechanisms of adaptive neurobiological plasticity. Neuroscience & Biobehavioral Reviews, in press.

BOOKS AND JOURNAL ISSUES EDITED (2 total) 1) Guest Editor, Behavioural Brain Research special issue “Adult neurogenesis and behavior”, 227: 2 (2012). 2) Co-Editor (with HG Kuhn), Neural Stem Cells in Development, Adulthood, and Disease. Volume in the Series: Stem Cell Biology and Regenerative Medicine. Series editor: Kursad Turksen. Springer Scientific, New York: Humana Press (2015).

MEDIA COMMUNICATIONS (5 total) 1) Eisch AJ. Microscopy II: Image Analysis & 3D Reconstruction, Purdue University Cytometry Laboratories, www.cyto.purdue.edu (2005). 2) Eisch AJ. Video of presentation as Inaugural Seymour Benzer Lecturer, National Academy of Sciences: http://www.youtube.com/DistinctiveVoicesBC#p/u/0/-jD5vl7xkuo. Sponsored by Nobel Laureate Sydney Brenner to honor researcher in neuroscience or genetics. Presented as part of “Distinctive Voices @ The Beckman Center” for the National Academy of Sciences, Irvine, CA (2011)

3) Eisch AJ. Interviewed for Brain Matters, UT Austin Graduate Student Podcast: http://brainpodcast.com/post/98909134504/one-of-our-favorite-guests-dr-amelia-eisch-gave or available via iTunes in Brain Matters podcast, episode released July 1, 2015. Recorded in Austin, TX (2014) 4) Eisch AJ. Featured Principal Investigator for NASA Space Radiation Element (SRPE) Newsletter, http://spaceradiation.usra.edu/newsletter/2014/Summer/ (2014)

13 Eisch, Amelia J. 5) Eisch AJ. http://gizmodo.com/the-surprising-effect-that-space-radiation-had-on-mouse-1737857245, http://www.ibtimes.com.au/mice-perform-better-space-radiation-ray-hope-human-colony-mars-1479833, http://myinforms.com/en-au/a/18488848-mice-perform-better-in-space-radiation-ray-of-hope-for-human- colony-on-mars/ (2015)

APPOINTMENTS, SOCIETIES, AND JOURNAL AFFILIATIONS

Member, Society for Neuroscience (000154765) 1991-present

Member, Integrative Biology Graduate Program at UT Southwestern 2002-present

President, UT Southwestern chapter of Sigma Xi 2005-2010 Honor Society for Scientist/Engineers

Member, UT Southwestern chapter of Sigma Xi 2005-2016 Honor Society for Scientist/Engineers

Co-founder and Organizer, Stem Cells in Neuroscience (SCIN) 2005-2015 Basic research workshop group at UT Southwestern

Member, Neuroscience Graduate Program at UT Southwestern 2008-present Member of Standing Study Section, CSR/NIH Neurobiology of Motivated Behavior (NMB) 2009-2013

Associate Editor, Neuroscience Letters 2009-2013 Neuro/gliogenesis, cell lineage/development, and cortical development

Review Editor, Frontiers in Neurogenesis 2009-present Editorial Board, Developmental Neuroscience 2011-2015

Editorial Board, European Journal of Neurodegenerative Diseases 2011-present

Member, International Society of Neurochemistry 2012-present Editorial Board, Brain Plasticity 2013-present

Member, Radiation Research Society 2013-present

Consulting Editor, Behavioral Neuroscience 2014-present

Invited Member, Central Nervous System Working Group (CNSWG) 2015-2017 NASA Space Radiation Element Panel that discusses adverse CNS effects of space radiation exposure and reports results to attendees of the annual meeting of Human Research and Performance Investigators Editorial Board, THREE (The Health Risks of Extraterrestrial Environments) 2015-2020 Associate Editor, NASA-sponsored encyclopedic on-line website on space radiation and human risk Member, International College of Neuropsychopharmacology (CINP) 2015-2017

Member, Philadelphia Chapter of the Society for Neuroscience (PCSfN) 2017-present

Member, Pavlovian Society 2017-present

Membership Committee, Radiation Research Society 2018-present

Vice President, Philadelphia Chapter of the Society for Neuroscience 2019

Ad-hoc reviewer for 60+ journals including Ageing Research Reviews, Behavioral Brain Research, Behavioral Pharmacology, Bioelectromagnetics, Biological Psychiatry, Brain Plasticity, Brain Research, Brain Research Bulletin, Cell Research, Cell Stem Cell, Cellular and Molecular Life Sciences, Cerebral Cortex, CNS Neurological Disorders and Drug Targets, Current Biology, Current Opinion in Neurobiology, Developmental Neuroscience, Drug and Alcohol Dependence, eLife, eNeuro, Epilepsia, European Journal of Neuroscience, Experimental Neurology, FASEB Journal, Frontiers in Neuroscience, Genes Brains and Behavior, Hippocampus, International Journal of Molecular Science, International Journal of Neuropsychopharmacology, International Journal of Radiation Oncology, Biology, Physics; Journal of Alzheimer’s Disease, Journal of Clinical Investigation, Journal of Comparative Neurology, Journal of Internal Medicine, Journal of Neurochemistry, Journal of Neuroendocrinology, Journal of Neuroscience, Journal of Neuroscience Research, Journal of Pharmacology and Experimental Therapeutics, Life Sciences in Space Research, Molecular and 14 Eisch, Amelia J. Cellular Neuroscience, Molecular Neurobiology, Molecular Pharmacology, Molecular Psychiatry, Nature, Nature Communications, Nature Medicine, Nature Neuroscience, Neurobiology of Aging, Neurobiology of Disease, Neurobiology of Learning and Memory, Neurobiology of Stress, Neuron, Neuropharmacology, Neuropsychopharmacology, Neuroscience, Neuroscience Letters, Neuroscience Research, Neurotoxicology and Teratology, Oncotarget, Pain, Pediatric Research, Physiology and Behavior, Proceedings of the National Academy of Science-USA, Progress in Neuropsychopharmacology and Behavioral Pharmacology, Psychiatry Research, Psychoneuroendocrinology, Psychopharmacology, Public Library of Science Biology, Public Library of Science One, Radiation Research, Science, Scientific Reports, Stem Cells, Stem Cell Research, Synapse, Trends in Neuroscience.

REVIEW PANELS FOR RESEARCH GRANTS (International, National, Federal, State, Local Agencies) Date of confirmed future reviews in italics

INTERNATIONAL review panels (mail reviewer unless otherwise indicated) Wellcome Trust, United Kingdom 2004, 2006 Medical Research Council of South Africa, South Africa 2006 Auckland Medical Research Foundation, New Zealand 2008 Ontario Mental Health Foundation, Canada 2008 Deutsche Forschungsgemeinschaft (German Research Foundation) 2010 Science Foundation Ireland mail reviewer: 2010, 2012 site reviewer: 2015 Swiss National Science Foundation 2014 Marsden Fund, Royal Society of New Zealand 2014

NATIONAL (NON-FEDERAL) review panels Alzheimer’s Association 2007

FEDERAL review panels (in-person review unless otherwise indicated) NIH/Center for Scientific Review Brain Disorders and Clinical Neuroscience study section (ZRG1-CNNT 02) 2003 Behavioral Neuroscience F03A Fellowship Meeting 2006, 2014 Special Emphasis Panel/Scientific Review Group (ZDA1 RXL-E 24) 2006 Special Emphasis Panel/Scientific Review Group (ZDA1 RXL-E-03) 2006 Neural Cell Fate (NCF) Study Section, ad hoc 2008 Substance Abuse and Glial Regulation of Nervous System Function (ZDA MXH-H 11 1; RFA DA-08-013.14.15) 2008 Neurobiology of Motivated Behavior (NMB) Study Section, ad hoc 2008 Neurodevices and Neuroimaging Review Panel (ZRG1 ETTN-F (99) RRFA) 2009 Special Emphasis Panel/Scientific Review Group (ZRG1 BCMB-A 51) 2009 Special Emphasis Panel/Scientific Review Group (ZRG1 MDCN-A 58) 2009 Special Emphasis Panel/Scientific Review Group (ZRG1 ETTN-A 58) 2009 Neurobiology of Motivated Behavior (NMB) Study Section, standing member 2009-2013 Neurodevelopment, Synaptic Plasticity and Neurodegeneration F03A Fellowship Meeting 2010 Transformative R01 panel 2012 (mail) Special Emphasis Panel/Scientific Review Group (ZRG1 MDCN-G 02) 2012 (internet assisted meeting) Comparison of Integrated Review Groups 2014 (internet assisted meeting) Special Emphasis Panel/Scientific Review Group (ZMH1 ERB-Y) 2014 (teleconference) NIMH Fellowship Review Special Review, Molecular, Cellular and Developmental Neurosciences 2017 (teleconference) 2017/05 ZRG1 MDCN-C (04) M

15 Eisch, Amelia J. Molecular Neuropharmacology and Signaling Study Section (MNPS) 2017 (teleconference) Special Review, Neural Regulation of Cancer 2018 (virtual meeting) 2018/05 ZRG1 OBT-B (55) R Molecular Neuropharmacology and Signaling Study Section (MNPS) 2018 (teleconference) Molecular Neuropharmacology and Signaling Study Section (MNPS) 2018 (teleconference)

National Institutes of Health National Institute of Aging (NIA) P01 Reverse site visit meeting 2006 National Institute on Alcohol Abuse and Alcoholism (NIAAA) Stem Cell Research for Alcohol-related Disorders (RFA-ZAA1-GG22) 2002, 2003 Biomedical Research Subcommittee 2004 National Institute on Drug Abuse (NIDA) Cutting Edge Basic Research Award (CEBRA) 2003, 2004, 2005, 2009, 2011, 2015 Consequences of marijuana use on the developing brain (RFA-DA-04-016) 2004 Program Project Review Group (ZDA1 RXL-E 30) 2007 National Institute of Mental Health (NIMH) R03 B/Start study section 2004 HIV and Psychiatric Comorbidity (RFA-MH-07-020-021, ZMH1 ERB-S-07) 2006 Section on Neuroplasticity, NIMH Board of Scientific Counselors, ad hoc 2012, 2016 Neuroscience Predoctoral T32 Special Emphasis Review Panel 2018

National Space and Aeronautics Administration (NASA)/National Space Biomedical Research Institute (NSBRI) CNS NSCOR (program project) review panel 2007, 2012 Space Radiobiology Review Panel, CNS applications 2009, 2012, 2015 Postdoctoral Fellowship Review Panel 2011 (phone) Crew Health Step-2 Neurobehavioral Effects 2015 (teleconference) Crew Health and Performance in Space Exploration Missions 2017 (teleconference) Human Exploration Research Opportunities (NNJ16ZSA001N-FLAGSHIP1) NASA Research Opportunities in Space Biology (May ‘19) 2019 (Chair of committee) ROSBio 2019 Flight and Ground Review [19SB_FG], NNH18ZTT001N-FG

National Science Foundation 2007, 2015

STATE review panels NYSTEM (New York State Department of Health and the Empire State Stem Cell Board) 2008

LOCAL/INSTITUTIONAL review panels NIH SCORE program, UTHSC San Antonio 2005-2007 NIH Center for Environmental and Rural Health Pilot Grant Program 2005 Texas A&M University Internal Grant Program, City University of New York 2007 NIH Alzheimer’s Disease Center Pilot Grant Program 2008 UT Southwestern Medical Center Women’s Health Research, Yale University Medical School 2010 Pre-NIH Internal Grant Review Program 2015 University of Alabama Birmingham 16 Eisch, Amelia J.

NATIONAL AND INTERNATIONAL PRESENTATIONS AND WORKING GROUP PARTICIPATION (149 total)

1) 03/00 Boston College, Department of Psychology, Boston, MA

2) 08/00 National Institute on Drug Abuse, Molecular Genetics Laboratory, Bethesda, MD

3) 08/0 Netherlands Institute for Brain Research, “Plasticity in the Adult Brain”, Amsterdam, the Netherlands

4) 01/02 Grand Rounds in Psychiatry, UT Southwestern Medical Center, Dallas, TX

5) 02/02 INSERM Phillipe Laudat Conference on “Neural Stem Cells: From Development to the Clinic” Aix-les-Bains, France 6) 05/02 Regis University, Denver, CO

7) 06/02 Dutch Endo-Psycho-Neuro Conference. Session on “Adult Neurogenesis: Potential and Problems”, Doorwerth, The Netherlands

8) 02/03 National Institute of Drug Abuse, workshop on “Stem Cells and Drug Abuse”, Bethesda, MD

9) 04/03 UT Texas Health Science Center, Department of Biology. San Antonio, TX 10) 05/03 Society for Biological Psychiatry. Session on “Environmental and Pharmacological Regulation of Adult Neurogenesis”, Philadelphia, PA

11) 05/03 The Catholic University of Korea, College of Medicine. Seoul, South Korea

12) 06/03 University of Illinois, Champaign Urbana, Department of Psychology. Champaign, IL

13) 11/03 Invited to present research as winner of Young Investigator Award National Alliance for Research on Schizophrenia and Depression. New York, NY 14) 12/03 University Health Science Center, Department of Pharmacology. Denver, CO

15) 03/04 6th Neurochemistry Winter Conference. Session on “Drug Addiction and Hippocampal Plasticity”, Solden, Austria

16) 03/04 Trinity College, Department of Biology. San Antonio, TX

17) 04/04 Texas A&M, Department of Psychology. College Station, TX

18) 05/04 Harvard University, McLean Hospital, Department of Psychiatry. Belmont, MA

19) 10/04 National Institute of Drug Abuse, workshop on “Mechanisms of Brain Resiliency and Repair”, Bethesda, MD

20) 10/04 Co-Chair of minisymposium “New Horizons for New Neurons: Adult Neurogenesis and Psychiatry” selected for annual meeting of the Society for Neuroscience, San Diego, CA (inaugural year of minisymposium)

21) 01/05 Elan Pharmaceuticals, South San Francisco, CA

22) 09/05 Yale University, Department of Psychiatry. New Haven, CT

23) 01/06 Invited participant, The Academy of Medicine, Engineering and Science of Texas (TAMEST) annual conference, Houston, TX

24) 02/06 UT Austin, Department of Psychology. Austin, TX

25) 03/06 Invited participant, NIH Blueprint meeting on neurodegeneration, Bethesda, MD

26) 09/06 Texas Academy of Math and Sciences, University of North Texas. Denton, TX

27) 11/06 Howard University, Department of Biology. Washington, DC

28) 05/07 Katholieke Universiteit Leuven, Flanders Institute for Biotechnology (VIB), Leuven, Belgium 29) 06/07 University Medical Centre Groningen, Behavioral & Cognitive Neurosciences Symposium on “Glia and stem cells: new functions beyond support and repair”. Groningen, The Netherlands 30) 09/07 Texas Academy of Math and Sciences, University of North Texas. Denton, TX

31) 09/07 University of New Mexico, Department of Neurosciences. Albuquerque, NM

17 Eisch, Amelia J. 32) 10/07 Korean Society of Medical Biochemistry and Molecular Biology Autumn Symposium, Seoul, South Korea

33) 10/07 National Aeronautics and Space Administration, Houston, TX 34) 11/07 UT Southwestern Medical Center, Neuroscience Seminar for “Genes to Behavior: New Horizons in the Treatment of Brain Disease”. Dallas, TX

35) 11/07 University of North Texas, Biological Sciences Seminar. Denton, TX

36) 03/08 UT Southwestern Medical Center, Cancer Center Retreat, Dallas, TX

37) 04/08 UT Southwestern Medical Center, STARS Symposium on “What’s New in Stem Cells?”, Dallas, TX

38) 06/08 National Aeronautics and Space Administration, Annual meeting of CNS Researchers, Philadelphia, PA

39) 09/08 Emory University, Department of Pharmacology, Atlanta, GA

40) 09/08 National Institute of Drug Abuse, Intramural Research Speaker Program, Bethesda, MD 41) 10/08 Texas Academy of Math and Sciences, University of North Texas. Denton, TX

42) 11/08 Invited speaker, National Institute of Drug Abuse premeeting at the annual meeting for the Society for Neuroscience on “Cortical Development and Substance Abuse Induced Abnormality.” San Diego, CA

43) 11/08 Chair and speaker, inaugural minisymposium “Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?” selected for annual meeting of the Society for Neuroscience, San Diego, CA

44) 12/08 Howard University School of Medicine, Department of Physiology and Biophysics. Washington, DC

45) 12/08 University of Toledo Health Science Center, Department of Neuroscience, Toledo, OH 46) 01/09 Invited speaker, 24th Annual Winter Conference on Current Issues In Developmental Psychobiology, St. Croix, United States Virgin Islands 47) 02/09 Invited speaker, meeting of the American Neuropsychiatry Association as part of session entitled "New Approaches to the Modulation of Emotional Circuitry," San Antonio, TX 48) 03/09 Invited speaker, “Neurofest”, State University of New York Upstate Medical Center, Syracuse, NY

49) 04/09 Invited speaker, meeting of the American Society for Pharmacology and Experimental Therapeutics as part of session entitled "Neuroplastic and Neurodegenerative Changes Associated with Drug Abuse and Addiction," New Orleans, LA

50) 05/09 BIO International Technology Convention Symposium, session on "Neurogenesis: Enhancing brain cell growth for the treatment of depression," Atlanta, GA

51) 06/09 CREST Neuroscience International Symposium, session on “Hippocampal neurogenesis: its implication in neural functions and mental diseases", Awaji Island, Japan

52) 06/09 Kyoto University, Institute for Virus Research. Kyoto, Japan

53) 06/09 Hoshi University, School of Pharmacy and Pharmaceutical Sciences. Tokyo, Japan

54) 06/09 Tohoku University, Department of Developmental Neuroscience. Sendai, Japan

55) 07/09 National Institute for Medical Research, London, England

56) 07/09 Helmholtz Zentrum München, Munich, Germany

57) 07/09 Center for Regenerative Therapies, Dresden, Germany

58) 07/09 Hoffman La-roche, Basel, Switzerland 59) 07/09 International Heavy Ion Symposium, Cologne, Germany

60) 07/09 International Narcotics Research Conference, NIDA Symposium speaker, Portland, OR

61) 07/09 UT Southwestern Medical Center, Student Undergraduate Research Fellowship (SURF) series Dallas, TX 62) 09/09 University of South Dakota, Sanford School of Medicine. Invited speaker for annual symposium on “Research Frontiers in Brain Function and Disorders”. Ponca, NE 18 Eisch, Amelia J. 63) 10/09 UT Southwestern Medical Center, Student Teacher Access to Resources at UT Southwestern (STARS). Symposium on Radiation Risks Associated with Space Travel. Dallas, TX

64) 11/09 Hotchkiss Brain Institute, University of Calgary, Calgary, Ontario, Canada 65) 12/09 UT San Antonio, Department of Psychiatry Grand Rounds Speaker. San Antonio, TX

66) 04/10 The Scripps Research Institute, La Jolla, CA

67) 04/10 Binghamton University, Harpur College Dean’s Workshop Series in Psychology. Binghamton, NY 68) 05/10 Canadian College of Neuropsychopharmacology, Speaker for Special Presidential Lecture Series on “Adult Hippocampal Neurogenesis and Psychiatry”. Ottawa, Canada

69) 05/10 NASA, Debate Participant for Panel on CNS Risks, 21st Annual NASA Space Radiation Investigators' Workshop, Upton, NY

70) 06/10 NASA, Space Radiation Summer School speaker, Brookhaven, NY

71) 06/10 UT Southwestern, Student Teacher Access to Resources at Southwestern (STARS) summer seminar series, Dallas, TX

72) 07/10 International Narcotics Research Conference, Featured Symposium Speaker, Malmö, Sweden 73) 07/10 University of Gothenburg, Institute for Brain Research, Gothenburg, Sweden

74) 07/10 UT Southwestern. Summer Undergraduate Research Fellowship (SURF) seminar series, Dallas, TX 75) 08/10 23rd Annual European College of Neuropsychopharmacology (ECNP), invited Speaker for symposium “Stress and affective disorders: new insights from animal models”. Amsterdam, The Netherlands.

76) 09/10 Institute of Neuroscience, INSERM, Bordeaux, France 77) 09/10 European Behavioural Pharmacology Society (EBPS) workshop on “Drugs, Psychiatric Disorders, and Neurogenesis. Session “Drugs of abuse and new neurons.” Tours, France 78) 09/10 University of Pittsburgh School of Medicine, Translational Neuroscience Programs, Pittsburgh, PA

79) 10/10 1st Meeting on the Pharmacological Modulation of Adult Neurogenesis, Closing Plenary Lecturer, Novaro, Italy

80) 11/10 UT Southwestern, Student Teacher Access to Resources at UT Southwestern (STARS). Fall symposium speaker on “The Nervous System”, Dallas, TX

81) 11/10 Kavli Frontiers of Science Meeting, National Academy of Sciences, USA, Chair of and speaker for session “Neural Stem Cells”. The Beckman Center, Irvine, CA

82) 11/10 Mt. Sinai School of Medicine, Friedman Brain Institute Translational Neuroscience Seminar Series, NY, NY

83) 12/10 University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, Philadelphia, PA

84) 01/11 Keystone Meeting on Adult Neurogenesis, Taos, NM

85) 02/11 Inaugural Seymour Benzer Lecturer, National Academy of Sciences. Sponsored by Nobel Laureate Sydney Brenner to honor researcher in neuroscience or genetics. Presented as part of “Distinctive Voices @ The Beckman Center” for the National Academy of Sciences, Irvine, CA. Video available: http://www.youtube.com/DistinctiveVoicesBC#p/u/0/-jD5vl7xkuo

86) 09/11 Euroglia Meeting, Session “Glia and neural stem cells in cognitive and psychiatric disorders”. Prague, Czech Republic

87) 09/11 Italian Society of Pharmacology 35th National Congress, Plenary Lecturer. Bologna, Italy 88) 11/11 Anxiety and Depression: 21st Neuropharmacology Conference. Session “Emerging non- monoaminergic targets”. Tyson’s Corner, VA. Due to unexpected family medical reasons, a colleague (Dr. Diane Lagace, University of Ottawa) presented our work on my behalf.

89) 03/12 UT Dallas, Center for Brain Health, Brain Health Scientific Frontiers lecture series. Dallas, TX 90) 07/12 Meeting of EPHAR: The Federation of European Pharmacological Societies. Co-Chair and Speaker 19 Eisch, Amelia J. for symposium sponsored by the Italian Society of Pharmacology on “The pharmacological modulation of adult neural stem/progenitor cells”. Granada, Spain 91) 09/12 Pfizer Pharmaceuticals, Psychiatric and Behavioral Disorders Group, Cambridge, MA

92) 10/12 Annual Meeting of The Society of Neuroscience, Clinical Neuroscience Social speaker. New Orleans, LA 93) 10/12 Annual Meeting of The Society of Neuroscience, invitation-only information exchange between grantees from National Institute on Drug Abuse (NIDA) and representatives of the Institut National de la Santé et de la Recherche Medicale (INSERM), New Orleans, LA

94) 04/13 Meeting of The International Society for Neurochemistry and The American Society for Neurochemistry, Speaker for symposium on “Neurogenesis and Neuropsychiatric Diseases”, Cancun, Mexico

95) 04/13 UT Southwestern Medical Center, Department of Psychiatry, Grand Rounds, Dallas, TX

96) 09/13 Annual meeting of the Radiation Research Society, New Orleans, LA 97) 10/13 Texas A&M University (TAMU) Institute for Neuroscience (TAMIN) Seminar Series. College Station, TX 98) 11/13 Annual meeting of The Society of Neuroscience, Clinical Neuroscience Social speaker. New Orleans, LA

99) 11/13 University of Gothenberg, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Gothenberg, Sweden

100) 01/14 University of Texas at Dallas, Brain Health Center, BrainHealth Frontiers Lecture Series, Dallas, TX

101) 01/14 University of Texas at Dallas, Brain Health Center, Trainee Education Seminar, Dallas, TX 102) 02/14 Centre for Cellular and Molecular Biology, Hyderabad, India

103) 02/14 Conference on Adult Neurogenesis: From Stem Cells to Therapies Symposium, sponsored by Tata Institute of Fundamental Research, Mumbai, India

104) 02/14 National Centre for Biological Sciences (TIFR), Department of Neurobiology, Bangalore, India 105) 02/14 NASA, Human Research Program Investigator’s Workshop, Session “Central Nervous System Risks”, Galveston, TX 106) 02/14 Keynote speaker for NEURON (North East Undergraduate Research Organization for Neuroscience), Quinnipiac University Medical School, North Haven, CT

107) 02/14 Neuroscience Seminar Series speaker, Interdepartmental Neuroscience Program, Yale University, New Haven, CT 108) 03/14 University of Rochester, Department of Neurobiology and Anatomy. Rochester, NY

109) 03/14 UT Austin, Department of Psychology. Austin, TX

110) 04/14 University North Texas, Keynote Speaker for the Biology Graduate Student Association Research Day. Denton, TX 111) 04/14 Wesleyan University, Department of Biology, Neuroscience, and Behavior. Middletown, CT

112) 05/14 UT San Antonio Health Science Center, Keynote speaker for Center for Biomedical Neuroscience retreat, San Antonio, TX

113) 05/14 Cleveland Clinic, Lerner Research Institute, Cleveland, OH

114) 07/14 UT Southwestern Medical Center, Seminar speaker for Student-Teacher Access to Resources at Southwestern (STARS) Program. Dallas, TX

115) 07/14 UT Southwestern Medical Center, Seminar speaker for Student Undergraduate Research Fellowship (SURF) Program. Dallas, TX 116) 09/14 Works in Progress presenter, UT Southwestern’s NASA Specialized Center of Research (NSCOR) for the Estimation of Solid Tumor Cancer Risks from Space Radiation, Dallas, TX 117) 09/14 Speaker and Faculty Mentor, Route28 Summits in Neurobiology: “Adult Neurogenesis: New Perspectives.” Frauenchiemsee Bavaria, Germany 20 Eisch, Amelia J. 118) 11/14 Speaker, German Stem Cell Network (GSCN) and 6th meeting of the BMBP-funded Independent Research Groups in the Neurosciences, Joint Satellite Meeting on Neural Stem Cells, Heidelberg, Germany 119) 01/15 Speaker, Thirty-Ninth Annual Winter Conference on The Neurobiology of Learning & Memory, Session on: Adult Hippocampal Neurogenesis: Behavioral Functions at the Intersection of Cognition and Emotion. Park City, UT 120) 01/15 Department seminar speaker, University of Alabama, Birmingham, Department of Neurobiology, Birmingham, AL

121) 03/15 Cajal Institute, CSIC. Madrid, Spain 122) 03/15 University of Valencia, Invited speaker for First Joint Meeting University of Valencia and UT Southwestern Medical Center. Valencia, Spain 123) 04/15 University of Pennsylvania/Children’s Hospital of Philadelphia, Department of Anesthesiology and Critical Care. Philadelphia, PA 124) 06/15 UT Southwestern Medical Center, Seminar speaker for Student Undergraduate Research Fellowship (SURF) Program. Dallas, TX 125) 07/15 9th IBRO World Congress, Symposium speaker, “Adult neurogenesis: from circuit to function”. Rio de Janeiro, Brazil (https://www.youtube.com/watch?v=T1aEzEAzwNM) 126) 07/15 XII European Meeting on Glial Cells in Health and Disease (Euroglia), Symposium Co-organizer and speaker, “A Disrupted Gliogenic/Neurogenic Equilibrium Is Essential for the Injury Response of Adult Neural Stem Cells”. Bilbao, Spain 127) 07/15 Department of Neuroscience, University of Connecticut Health Center. Farmington, CT 128) 10/15 Annual retreat, NIDA-sponsored PharmacoNeuroImmunology Training Program (T32 DA007097) at University of Minnesota, Keynote speaker. St. Paul, MN 129) 11/15 Department of Biology, Drexel University, Graduate Student-Nominated 2015 Seminar Speaker. Philadelphia, PA 130) 03/16 International meeting Inaugural Fusion Neurogenesis Meeting: implications for lifelong development and disease, Invited speaker. Cancun, Mexico 131) 03/16 UT Southwestern Medical Center, Radiation Oncology Retreat. Dallas, TX 132) 06/16 International Behavioral Neuroscience Meeting (IBNS), Speaker for Symposium “Resilience Redux: Better Living Through Neurobiology Research”. Budapest, Hungary 133) 07/16 3rd European Conference on Adult Neurogenesis, Invited speaker. Bordeaux, France 134) 11/16 Co-Chair of minisymposium “Spanning the central-peripheral divide: bridging the gap to find novel strategies to target depression” selected for annual meeting of the Society for Neuroscience, San Diego, CA 135) 01/17 NASA Human Research Program/Investigators Workshop Meeting. Chair of session on CNS effects. Galveston, TX, USA 136) 02/17 Children’s Hospital of Philadelphia (CHOP) Intellectual and Developmental Disabilities Research Center. Invited speaker. Philadelphia, PA USA 137) 03/17 University of Richmond, Department of Psychology. Invited speaker. Richmond, VA, USA 138) 06/17 Translation workshop invitee and participant, NASA Human Research Program’s Space Radiation and Human Factors & Behavioral Performance organizations. Johnson Spaceflight Center, Houston, TX, USA 139) 09/17 Temple University, Center for Substance Abuse, Department of Psychology. Invited speaker. Philadelphia, PA, USA 140) 10/17 Annual meeting of the Radiation Research Society, Symposium speaker. Cancun, Mexico

141) 12/17 Department of Anesthesiology and Critical Care, Research in Progress, Title of talk: “New neurons in the postnatal brain: what are they good for? And what is good for them?” Hospital of the University of Pennsylvania. Philadelphia, PA 142) 06/18 University at Buffalo, 2nd Annual Stem Cells in Regenerative Medicine Symposium, Speaker, “New neurons in the postnatal brain: what are they good for? And what is good for them”. Buffalo, NY 21 Eisch, Amelia J. 143) 06/18 International Behavioral Neuroscience Meeting (IBNS), Speaker for Symposium “Optimizing Brain Performance: Identifying Mechanisms of Adaptive Neurobiological Plasticity”. Title of talk: “Crossing the memory-mood divide: stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive and improves memory in mice”. Boca Raton, FL143) 144) 10/18 Georgia State University, Brains & Behavior Distinguished Lecture Series. Atlanta, GA 145) 11/18 Children’s Hospital of Philadelphia, Speaker, 2018-2019 Faculty Lecture Series. Philadelphia, PA 146) 02/19 EMBO International Neurogenesis Conference, Speaker, Bangalore, India 147) 03/19 International meeting Inaugural 2nd Neurogenesis Meeting: implications for lifelong development and disease, Invited speaker. Title of talk: #ItsBetterUpstream? Targeting Hippocampal Afferents to Manipulate Behavior. Nassau, The Bahamas 148) 04/19 Lifespan Brain Institute (LiBI) symposium "Early Contributors and Modulators of Brain Development", University of Pennsylvania Perelman School of Medicine and Children’s Hospital of Philadelphia, Invited speaker. Title of talk: New Neurons in the Postnatal Brain: What Are They Good For? And What Is Good For Them? Philadelphia, PA 149) 04/19 Department of Psychology, Colby College, Invited speaker. Waterville, ME Future presentations 10/19 Department of Psychiatry, UT Southwestern Medical Center, Grand Rounds Speaker, Dallas, TX 03/20 Neuroscience Program, University of Massachusetts Medical School, Annual Student-Selected Speaker, Worcester, MA 03/20 Neuroscience P01 Speaker, University of Maryland School of Medicine Medical School, Baltimore, MD

MEETING ORGANIZATION 1) Co-organizer, Philadelphia Chapter of the Society for Neuroscience Annual Meeting, held April 2019, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 2) Organizer, CHOP Division of Anesthesiology Basic Research, Neurobiology Seminar, Philadelphia, PA (2018-2019, 2019-2020)

SERVICE

INSTITUTIONAL SERVICE Service, UT SOUTHWESTERN MEDICAL CENTER Judge, predoctoral Sigma Xi abstract competitions 2002-2010 Judge, Graduate Student Organization and Postdoctoral Association poster sessions 2002-2010 Organizer, “Fourth Academy” medical student event on exercise and the brain 2004 Member, Six-year Planning Committee for 2008-2014 2005-2009 Ph.D. and Postdoctoral Research Training Subcommittee Organizer and Co-founder of Stem Cells in Neuroscience (SCIN) 2005-present Workshop group at UT Southwestern. Organizes “works in progress” talks by UT Southwestern graduate student and postdoctoral researchers in the field of neural stem cell research. President of UT Southwestern chapter of Sigma Xi 2005-2010 Honor Society for Scientist/Engineers. Spearheaded annual graduate student/postdoctoral fellow abstract competition. Speaker, Medical Science Training Program Women’s Luncheon 2006 Judge, postdoctoral Sigma Xi abstract competitions 2006-2009 Speaker, Medical Science Training Program Women’s Luncheon 2009 Member, Six-year Planning Committee for 2010-2016 2009-2011 Ph.D. and Postdoctoral Research Training Subcommittee President Ex-Officio, UT Southwestern Sigma Xi chapter, Scientific Honor Society 2010-2011 Member, Six-year Planning Committee for 2012-2018 2011-2016

22 Eisch, Amelia J. Ph.D. and Postdoctoral Research Training Subcommittee Member, Disability Accommodations Committee 2013-2016 Medical, Graduate, and Allied Health Schools Volunteer Mentor, Faculty Summer Sabbatical Program 2014-2016 University of Texas at El Paso/UTSW BUILD (Building Infrastructure Leading to Diversity) grant

Moderator and Participant, Panel “Effectively Facilitating a Journal Club” 2015 Southwestern Academy of Teachers (SWAT) Annual Educational Symposium Inaugural faculty member, UT Southwestern chapter of SACNAS 2015 (Society for the Advancement of Chicanos/Hispanics and Native Americans in Science) Moderator and Participant, Panel “How to Run an Effective and Efficient Basic Science Laboratory” 2016 SACNAS Quarterly UT Southwestern Meeting Moderator and Participant, Panel “Effective Laboratory Management” 2016 SWAT Annual Educational Symposium

Service, DEPARTMENT OF PSYCHIATRY, UT SOUTHWESTERN

Director, Histology, Imaging, and Confocal Microscopy Services 2002-2010 Confocal facility for the Department of Psychiatry and UT Southwestern Cancer Center Research and Education Director, Summer Training in Drug Abuse Research 2004-2009 Education Training Grant (R25 DA18843; PI: B. Adinoff) Administrator, Basic Science Training in Drug Abuse 2005-2008 Institutional Training Grant, T32 DA7290 Administrator, Basic Science Training in the Neurobiology of Mental Illness 2005-2008 Institutional Training Grant, T32 MH076690 Principal Investigator, Basic Science Training in Drug Abuse 2008-2016 Institutional Training Grant, T32 DA7290 Director, Quantitative Morphology Core 2010-2016 Offers consultation and services to Department of Psychiatry researchers relevant to tissue preparation, immunohisto- and cytochemical staining, and microscopic quantification analysis. Member, Department of Psychiatry Faculty Search Committee 2011-2016

Service, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE/CHOP Member, PennMed Neuroscience Graduate Group (NGG) admissions committee 2016-present Co-Chair, 2019-present

Member, Steering committee member, CHOP IDDRC (Intellectual and Developmental Disabilities Research Center) training grant (T32-NS007413, PI: MB Robinson) 2016-present

Member, PennMed NGG Executive Committee 2017-present

Member, CHOP Animal Space Committee/Department of Veterinary Medicine 2016-2017 Member, CHOP Test of Change Committee 2017-2018

Faculty Mentor, CHOP Office of Postdoctoral Affairs 2017 Responsible Conduct of Research Fall Event

Member, CHOP Department of Veterinary Medicine Faculty Advisory Committee 2018-present Vice Chair, 2019-present

Invited Leader, CHOP Women’s Employee Resource Group Speed Networking 2018

Discussion Leader, The Penn Reading Project: “Year of Why” 2018 The Bridge of San Luis Rey by Thornton Wilder

CHOP Postdoctoral Fellowship for Academic Diversity 2018-present Faculty Advisor and Committee Member

23 Eisch, Amelia J. Biomedical Graduate Studies Liaison, UPenn Graduate Council of Faculties (GCF) 2018-present One of two BGS members serving on this advisory body to the Provost and Vice Provost for Education GCF review liaison, Earth & Environmental Science Graduate Group, December 2018

CHOP Office of Academic Training and Outreach Programs 2018-present Panel member, “Preparing for Faculty Positions in Academia: The Interview”, Oct 2018 Panel moderator, “Preparing for Faculty Positions in Academia: Starting Up Your First Lab”, Mar 2019

Penn Biomedical Postdoctoral Programs 2019-present Discussion Leader, Research Misconduct and Policies for Handling Misconduct, Mar 2019

Member, CHOP Neuroscience Research and Innovation Workgroup 2019-present Basic and Translational Science Subgroup

Member, CHOP IDDRC Alavi-Dabiri Postdoctoral Fellowship committee 2019-present

Discussion Leader, The Penn Reading Project: “Year of Data” 2019 The Weapons of Math Destruction by Cathy O'Neil

CHOP Postdoctoral Fellowship for Academic Diversity 2019-present Chair

TEACHING (Medical, Predoctoral, Postdoctoral, and Postgraduate)

MEDICAL AND GRADUATE SCHOOL DIDACTIC AND SMALL GROUP TEACHING Teaching, UT SOUTHWESTERN MEDICAL CENTER Lecturer, Neurobiology of Drug Addiction, Neuroscience Program (3 lectures/year) 2000-2007 Lecturer, Neuropharmacology, Neuroscience Program (2 lectures/year) 2000-2007 Discussion Leader, Responsible Conduct of Science, DBS Graduate Core Course 2000-2007 Co-Leader, Neurodegeneration/Neuroplasticity Journal Club, Integ. Biology Program 2000-present Lecturer, Medical Student Clerkship rotations (3 lectures/year) 2003, 2004 Term paper reader, DBS Graduate Core Course (2 papers/year) 2003, 2005, 2006 Discussion leader for DBS Graduate Core Course (Cells thread) 2005, 2006 Lecturer, Medical Science Training Program seminar series 2005 Neuroscience Program pre-qualifier term paper reader 2006, 2009, 2010 Lecturer, Division of Basic Science training grant seminar 2007 Lecturer, Developmental Neurogenetics, Neuroscience Program (2 lectures/year) 2007-2011 Lecturer, Mechanisms of Drugs Action, Cell Regulation Program (2-4 lectures/year) 2008-2012 Lecturer, Neurobiology of Drug Addiction, Neuroscience Program (1 lecture/year) 2009, 2011, 2013, 2015 Lecturer, Texas Howard Hughes Medical Institution (HHMI) Fellows, Medical School (1 lecture/year) 2015 Teaching, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE Lecturer, Nervous System Injury and Repair, Neuroscience Graduate Group (NGG, 2 lectures/year) 2017 Founder and organizer, NGG GRIPPs (NGG and GLIA Research in Progress Presentations) 2017-present University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Preceptor, Independent Study (Ruthie Wittenberg), NGG (3h/week x 12 weeks) 2017, 2018 Lecturer, Depression/Anxiety/Fear Circuits, Clinical Neuroscience Training Program, (2h/year) 2018 Lecturer, Pharmacology Graduate Group (PGG) Journal Club, (1h/year) 2018

POSTGRADUATE TEACHING Postgraduate teaching, UT SOUTHWESTERN MEDICAL CENTER Lecturer, “Advanced Neuroscience”, PGYIII & IV Psychiatry Residents (5-7 lectures/yr) 2000-2003 Course co-director, “Advanced Neuroscience”, PGYIII & IV Psychiatry Residents. Coordinated lectures and presented 5-7 lectures/yr 2003-2007 Lecturer, “Advanced Neuroscience”, PGYIII & IV Psychiatry Residents (2 lectures/yr) 2008-2009

24 Eisch, Amelia J. TRAINING AND MENTORING COMMITTEES

POSTDOCTORAL MENTOR COMMITTEES (6 total) Postdoctoral mentor committee, UT SOUTHWESTERN MEDICAL CENTER (1) 1) Touyia Vu, PhD, K22 application mentoring committee, Fall 2014 Postdoctoral mentor committee, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE (2) 2) Alexey Ostroumov, PhD, working with John Dani. K01 application mentoring committee, Spring 2018 3) Melinda (Mindy) Snitow, PhD, working with Peter Klein. F32 application mentoring committee, Fall 2018 Postdoctoral mentor committee, CHILDREN’S HOSPITAL OF PHILADELPHIA (3) 4) Ana Cristancho, MD-PhD, working with Eric Marsh. K08 application mentoring committee, Fall 2019 5) Evelyn K. Shih, MD-PhD, working with Todd Kilbaugh. K08 application mentoring committee, Fall 2019 6) Joanna Mattis, PhD, received Ph.D. in from Stanford University (lab of Karl Deisseroth). Postdoctoral fellow working with Ethan Goldberg. DP5 application mentoring committee, Fall 2019

PREDOCTORAL DISSERTATION COMMITTEES (38 total) Predoctoral dissertation committees, UT SOUTHWESTERN MEDICAL CENTER (29 total) **diversity trainee 1) Trainee: Philip Wrage, Mentor: Malu Tansey. Cell Regulation graduate program. Thesis title: Adipose- derived stromal cells contribute to spinal cord repair but are not neural-crest derived stem cells. Defended June 2007. 2) Trainee: Kris Krishnan (MSTP), Mentor: Eric Nestler. Neuroscience graduate program. Thesis title: Vulnerability and resilience to social defeat: the role of neuroplasticity within the mesolimbic dopamine circuit. Defended May 2008. 3) Trainee: Diana Simmons, Mentor: David Self. Neuroscience graduate program. Thesis title: Mu opioid receptor involvement in cocaine addiction. Defended February 2009. 4) Trainee: Irene Masiulus Bowen, Mentor: Joachim Herz. Integrative Biology graduate program, Chair of committee. Thesis title: Regulation and function of ApoER2 and VLDLR in the central nervous and reproductive systems. Defended April 2009. 5) **Trainee: Sheila Alcantara, Mentor: Luis Parada. Genetics and Development graduate program. Thesis title: Neural stem cells in brain tumor development. Defended May 2009. 6) Trainee: Kristin Tolson, Mentor: Andrew Zinn. Integrative Biology graduate program. Thesis title: Postnatal Sim1 Deficiency Causes Hyperphagic Obesity. Defended October 2009. 7) Trainee: Euiseok Kim, Mentor: Jane Johnson. Neuroscience graduate program. Thesis title: Neurogenesis and Gliogenesis of Ascl1 (Mash1) Expressing Progenitors in the CNS. Defended December 2009. 8) **Trainee: Terina N. Martinez, Mentor: Malu Tansey. Integrative Biology graduate program. Thesis title: Neuroinflammation, TNF, and ceramide-dependent signaling: putative pathways for neurotoxicity in Parkinson’s disease. Defended March 2010. 9) Trainee: Ashley S. Harms, Mentor: Malu Tansey. Integrative Biology graduate program. Thesis title: The role of Tumor Necrosis Factor (TNF) in microglial activation and progressive degeneration of dopaminergic neurons. Defended March 2010. 10) Trainee: Kerstin Ure, Mentor: Jenny Hsieh. Integrative Biology graduate program, Chair of committee. Thesis title: Transcriptional regulation of adult neurogenesis by NRSF1/REST and NeuroD1. Defended October 2010. 11) Trainee: Lori Boies, Mentor: Robert Bachoo. Genes and Development graduate program, Chair of committee. Thesis title: Novel astrocyte-specific transgenic mice identify distinct populations of transient amplifying progenitor cells and long-lived neural stem cells in the subgranular zone of the adult mouse brain. Defended November 2010. 12) Trainee: Timothy Catchpole, Mentor: Mark Henkemeyer. Genetics and Development graduate program. Thesis title: Eph-B and Ephrin-B signaling in migration and proliferation of stem cells. Defended December 2010. 13) Trainee: Katie Seamans, Mentor: Matthew Goldberg. Neuroscience graduate program. Thesis title: Behavioral, Neurochemical, and Histological Characterization of Mice Deficient for Parkin, DJ-1, and Antioxidant Proteins. Defended April 2011. (Was committee member until 12/2010). 14) Trainee: Michael Edward Haws (MSTP), Mentor: Craig Powell. Neuroscience graduate program, 25 Eisch, Amelia J. committee Chair. Thesis title: Effects of Regional Deletion of Rab3A-interacting Molecule and PTEN on Brain Function. Defended May 2012. 15) Trainee: Alan Lesslyong, Mentor: Carol Tamminga. Neuroscience graduate program. On academic leave. 16) Trainee: Marian Marvin, Mentor: Matt Goldberg. Neuroscience graduate program. On academic leave. 17) Trainee: Angie Lin (MSTP), Mentor: David Russell. Integrative Biology graduate program, Chair of committee. Thesis topic: Cholesterol and NMDA receptors. Earned Master’s Degree, Summer 2010. 18) Trainee: Matthew Cummings, Mentor: Todd Eager. Integrative Biology graduate program. Thesis title: Therapeutic modulation of experimental autoimmune encephalomyelitis by gamma secretase inhibition. Defended December 2013. 19) Trainee: Charles Taylor, Mentor: Matt Goldberg. Neuroscience graduate program, Chair of committee. Returned to medical school program in 2012. 20) Trainee: Angela Walker, Mentor: Jeff Zigman. Neuroscience graduate program. Chair of committee. Thesis title: Investigating the enteroendocrine-brain axis: ghrelin and ECL cell physiology and ghrelin action on mood and complex eating. Defended April 2014. 21) **Trainee: Jessica Perez, Mentor: Carol Tamminga. Neuroscience graduate program. Will defend November 2018. 22) Trainee: Meghan Hennis, Mentor: Matt Goldberg. Neuroscience graduate program. Thesis title: Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson’s disease. Defended November 2013. 23) Trainee: Rebecca Brulet, Mentor: Jenny Hsieh. Genetics and Development graduate program. Thesis title: The role of NeuroD1 in physiological and pathological neurogenesis. Defended December 2016. 24) **Trainee: Daniel (D.J.) Araujo, Mentor: Genevieve Konopka. Neuroscience graduate program. Chair of committee. Thesis title: Brain-region-specific contributions of FoxP1 to autism and intellectual disability phenotypes. Defended June 2017. 25) Trainee: Courtney Lane (MSTP), Mentor: Joachim Herz. Neuroscience graduate program. Thesis title: ApoE receptors in Alzheimer’s and CNS function. Defended May 2015. 26) Trainee: Hillary Cansler, Mentor: Julian Meeks. Neuroscience graduate program. Member of her committee until Spring, 2016. 27) Trainee: Cindy Wang, Mentor: Jiang Wu. Genetics and Development graduate program. Earned Master’s, Fall 2014. 28) Trainee: Tabitha Ting (MSTP), Mentor: Beth Levine. Integrative Biology graduate program. Chair of committee until Spring, 2016. 29) **Trainee: Christine Ochoa, Mentor: Craig Powell. Neuroscience graduate program. Neuroscience graduate program. Thesis title: Understanding autism pathology: insights from genetic mouse model manipulation of KCTD13 and shank3. Defended June 2017. Predoctoral dissertation committees, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE (3 total) 30) Trainee: Julia (Kate) Brynildsen, Mentor: Julie Blendy. Neuroscience Graduate Group, PhD candidate. Chair of committee. 31) Trainee: Nathaniel (Nate) Sotuyo, Mentor: Stewart Anderson. Co-Mentor: Ethan Goldberg. Neuroscience Graduate Group, VMD-PhD candidate. 32) Trainee: Khadija Wilson, Mentor: Benjamin Garcia. Co-Mentor: Ethan Goldberg. Pharmacology Graduate Group, PhD candidate.

Predoctoral dissertation committees/External committee member, OTHER INSTITUTIONS (6 total) 33) Trainee: Gloria Mak, Mentor: Sam Weiss, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. Thesis topic: Social interactions and adult neurogenesis. Defended November 17, 2009. 34) Trainee: Maithe Arruda Carvalho, Mentor: Paul Frankland, University of Toronto, Toronto, Canada. Thesis title: A role for adult born neurons in memory processing. Defended September 18, 2012. 35) Trainee: Martina Boström, Mentor: Klas Blomgren, University of Gothenburg, Gothenburg, Sweden. Thesis topic: Influence of early life irradiation on hippocampal neurogenesis. Defended November 29, 2013. 36) Trainee: Steven Arriaga, Mentor: Brian Derrick, University of Texas San Antonio, TX, USA. Thesis 26 Eisch, Amelia J. topic: Vestibular loss and adult hippocampal neurogenesis. 37) Trainee: Elizabeth Belcher, Mentor: Kerry O’Banion, University of Rochester, NY, USA. Thesis topic: Inflammation and cognition. Defended June, 2019. 38) Trainee: Ian Mahar, Mentor: Mechawar Naguib, McGill University, Montreal, Canada. Thesis topic: Neuregulin-1/ErbB activity in hippocampal plasticity and psychopathology. Defended November, 2015.

PREDOCTORAL CANDIDACY EXAMINATION COMMITTEES (22 total) Candidacy exam trainees, UT SOUTHWESTERN MEDICAL CENTER (20) **diversity trainee 1) Eric Johnson, Integrative Biology graduate program. Spring 2003. 2) Rich Trinko, Neuroscience graduate program. Spring 2004. 3) Denise Ramirez, Integrative Biology graduate program. Spring 2005. 4) Inik Chang, Integrative Biology graduate program. Spring 2006. 5) **Terina Martinez, Integrative Biology graduate program. Spring 2007. 6) Ashley Harms, Integrative Biology graduate program. Spring 2008. 7) Angie Lin, Integrative Biology graduate program. Spring 2009. 8) Rachel Arey, Neuroscience graduate program. Spring 2009. 9) Yi Xu, Integrative Biology graduate program. Spring 2010. 10) Jueqi Chen, Integrative Biology graduate program. Spring 2011. 11) Daniel Epstein, Neuroscience graduate program. Spring 2011. Chair of committee. 12) Katelyn Finch, Integrative Biology graduate program. Spring 2012. 13) Lauren Luethy, Neuroscience graduate program. Spring 2012. Chair of committee. 14) Stephanie Lepp, Neuroscience graduate program. Fall 2012. 15) Ivan Lee, Integrative Biology graduate program. Spring 2013. Chair of committee. 16) Andrew Eugene Sohn, Neuroscience graduate program. Fall 2013. 17) Alexandra Willcockson, Integrative Biology graduate program. Spring 2014. 18) Elizabeth Pelser, Neuroscience graduate program. Fall 2014. 19) Fangzhou Zhao, Integrative Biology graduate program. Spring 2015. 20) Shidan Wang, Neuroscience graduate program. Fall 2015. Chair of committee.

Candidacy exam trainees, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE (2) 21) Ruthie Wittenberg, Neuroscience graduate group. Spring 2018. Chair of committee 22) Melanie Schaffer, Neuroscience graduate group. Spring 2019. Chair of committee

TRAINEES MENTORED IN LABORATORY RESEARCH

ROTATING PREDOCTORAL TRAINEES (39 total) Rotating predoctoral trainees, UT SOUTHWESTERN MEDICAL CENTER (35) **diversity trainee 1) Ozgur Karakazu, Winter 2003. 2) Michael Donovan, Spring 2003. 3) Ed Hurlock, Summer 2003. 4) Euiseok Kim, Fall 2003. 5) Denise Ramirez, Fall 2003. 6) Deanna Wallace-Black, Winter 2004. 7) **Charcacia Sanders, Spring 2004. 8) Michele Noonan (Maiden name: Ostrogonacz), Summer 2004. 9) **Amy Arguello, Fall 2004. 10) Nathan DeCarolis, Summer 2005. 11) **Phuong Tran, Fall 2005. 12) Anita Autry, Fall 2005. 13) **Terina Martinez, Winter 2005. 14) James Sullivan, Winter 2005. 15) Colleen Dewey, Spring 2006. 16) Kerstin Ure, Spring 2006. 27 Eisch, Amelia J. 17) Alan Lesselyong, Spring 2007. 18) Michael Robichaux, Summer 2008. 19) **Shamsideen Ojelade, first Fall rotation 2008. 20) **Phillip Rivera, second Fall rotation 2008. 21) Sarah Bulin, second Fall rotation 2008. 22) **Maria Carreira, first Fall rotation 2009. 23) Chris Walz, first Fall rotation 2009. 24) Aparna Sankararaman, second Fall rotation 2009. 25) **Marilyn Archer, second Fall rotation 2009. 26) Angela Walker, Winter rotation 2010. 27) Maithili Dalvi, Winter rotation 2010. 28) Jared Hooks, first Fall rotation 2010. 29) **Daniel Araujo, first Fall rotation 2011. 30) Cody Whoolery, first Fall rotation 2014. 31) Anant Gharpure, first Fall rotation 2014. 32) **Matthew Mendoza, second Fall rotation 2014. 33) Amy Zwierzchowski-Zarate, first Fall rotation 2015. 34) **Vanessa Torres, second Fall rotation 2015. 35) Yixin Zang, second Winter rotation 2016. Rotating predoctoral trainees, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE (4) **diversity trainee 36) **Naseem Jasmia, Neuroscience Graduate Group (NGG), Fall rotation 2016. 37) **Lyles R. Clark, NGG, Winter rotation 2017. 38) Darrell Eacret, NGG, Summer rotation 2017. 39) Delaney Fischer, NGG, Fall rotation 2017.

ROTATING MEDICAL STUDENT TRAINEES (4 total) UT SOUTHWESTERN MEDICAL CENTER (4) 1) Jessica L. Ables, MS1 rotation, Summer 2004 (later joined MSTP program). 2) Nora Edwards, MSTP rotation, Summer 2004. 3) Rania Shebaro, MS IV rotation, Summer 2008. 4) Mary-Katherin McGovern, MS1 rotation Summer 2010 (co-mentor with Shari Birnbaum).

ROTATING PSYCHIATRY RESIDENT TRAINEES (1 total) UT SOUTHWESTERN MEDICAL CENTER 1) Amit Pradhan, M.D., UT Southwestern Psychiatry PGYII Resident, Research-Track, Fall 2007.

PREDOCTORAL TRAINEES (13 total) Predoctoral trainees, UT SOUTHWESTERN MEDICAL CENTER (12) **diversity trainee 1) Michael H. Donovan Joined Eisch Lab in June 2003. Earned predoctoral trainee position on NIMH institutional National Research Service Grant (T32 MH076690). Received individual National Research Service Predoctoral Award from NIMH/NIH (F31 MH075457). Defended dissertation in Neuroscience Program in March 2008. Title: Regulation of adult hippocampal neurogenesis: Insights from mouse models of dementia and depression. After defense, Dr. Donovan accepted NIH postdoctoral fellowships in the labs of Dr. David Copenhagen and Dr. Larry Tecott (both at UCSF).

2) Gwyndolen C. Harburg Joined Eisch Lab in June 2004. Earned predoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290). Defended dissertation in Integrative Biology Program in June 2007. Title: The impact of opioids and opiates on adult hippocampal neurogenesis. After defense, Dr. Harburg completed postdoctoral fellowships in stem cell research with Jane Visvader (Walter 28 Eisch, Amelia J. and Eliza Hall Research Institute, Melbourne, Australia) and Dr. N. Hinck at UC Santa Cruz.

3) Michele A. Noonan (Maiden name: Ostrogonacz) Joined Eisch Lab in June 2005. Earned predoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290). Received individual National Research Service Predoctoral Award from NIDA/NIH (F31 DA021045). Defended dissertation in Neuroscience Program in December 2008. Title: The role of adult neurogenesis in cocaine addiction. After defense, Dr. Noonan took a postdoctoral fellowship in the lab of Linda Hsieh-Wilson (Cal Tech, HHMI). 4) **Amy A. Arguello Joined Eisch Lab in June 2005. Supported by a four-year predoctoral Diversity Supplement linked to Dr. Eisch’s grant entitled “Opiates and adult neurogenesis” (R01 DA016765) from NIH/NIDA. Defended dissertation in Neuroscience Program in January 2009. Title: The impact of chronic morphine on adult hippocampal progenitor cells and the neurogenic niche. After defense, Dr. Arguello accepted a postdoctoral fellowship in the laboratory of Christina Alberini at Mount Sinai School of Medicine, and then a second postdoctoral position with Rita Fuchs at University of North Carolina/University of Washington-Pullman. In 2014, received K99/R00 NIH/NIDA award.

5) Jessica L. Ables (MSTP student) Joined Eisch Lab in September 2005. Earned predoctoral trainee position on NIMH institutional National Research Service Grant (T32 MH076690). Defended dissertation in Integrative Biology Program in June 2009. Title: The role of Notch1 in adult hippocampal neurogenesis and function. After defense, Dr. Ables finished medical school/MD-PhD (at Mount Sinai School of Medicine) and accepted a postdoctoral fellowship in the laboratory of Nathaniel Heintz at The Rockefeller University.

6) Nathan A. DeCarolis Joined Eisch Lab in March 2006. Earned predoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290). Received individual NINDS National Research Service Predoctoral Award (F31 NS064632). Defended dissertation in Integrative Biology Program March 2010. Title: Exploring a functional disconnect between nestin-expressing Type-1 cells and adult hippocampal neurogenesis. After defense, Dr. DeCarolis accepted a postdoctoral fellowship in Theo Palmer’s laboratory, Stanford University.

7) **Phillip D. Rivera Joined Eisch Lab in January 2009. Passed qualifying exams in the Integrative Biology Program in July 2011. Supported by a four-year predoctoral Diversity Supplement linked to Dr. Eisch’s grant entitled “Opiates and adult neurogenesis” (R01 DA016765) from NIH/NIDA beginning 5/15/10. Earned predoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA 007290, January 1 2014 – December 2014). Defended dissertation in Integrative Biology Program December 2014. Title: Exploring the role and sensitivity of the hippocampal dentate gyrus: from addiction-relevant memories to the influence of space radiation on hippocampal neurogenesis. After defense, Dr. Rivera accepted a postdoctoral fellowship in the laboratory of Dr. Staci Bilbo at Duke University.

8) Sarah E. Bulin Joined Eisch Lab in January 2009. Passed qualifying exams in the Neuroscience Program in Spring 2010. Submitted an individual National Research Service Predoctoral Award application to NIDA entitled Morphine and adult neurogenesis which received a score of 32. Earned predoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290, October 1 2012 – March 31 2015).

29 Eisch, Amelia J. Defended Ph.D. in Integrative Biology from UT Southwestern March 27, 2015. Title: The role of adult hippocampal neurogenesis in morphine addiction. After defense, Dr. Bulin began a postdoctoral fellowship in the laboratory of Dr. David Morilak at UT Health Science Center San Antonio.

9) Ashley S.Harms Title: The role of Tumor Necrosis Factor (TNF) in microglial activation and progressive degeneration of dopaminergic neurons Defended Ph.D. in Integrative Biology from UT Southwestern March 2010 (lab of Malu Tansey). Joined Eisch laboratory for a short time (March-May 2010) while waiting for the start of her postdoctoral fellowship in the laboratory of David Standeart at University of Alabama, Birmingham.

10) Aparna Sankararaman Joined Eisch Lab in April 2010. Passed qualifying exams in the Integrative Biology Program in Spring 2011. Dismissed from laboratory and UT Southwestern Graduate Program in May 2012 for scientific misconduct and academic dishonesty. Inquiries about this incident can be addressed to Dr. Eisch, Dr. Yi Liu (head of Integrative Biology Graduate Program), and/or the UT Southwestern Office of the Dean.

11) Cody W. Whoolery Joined Eisch Lab in January 2015. Joined Integrative Biology Graduate Program. Earned predoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290, July 1, 2015 - present). Effective August 27, 2016 became co-mentored by Dr. Ann Stowe (UTSW) and Dr. Eisch (who began at PennMed Sept 1, 2016). Graduated April, 2018 from Integrative Biology Graduate Program. After defense, Dr. Whoolery accepted a position at Reata Pharmaceuticals, succeeding in his career goal of being placed on a leadership track in a biotech/pharmaceutical company.

12) **Matthew L. Mendoza Joined Eisch Lab in January 2015. Joined Neuroscience Graduate Program. Earned predoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290, June 1, 2015 - present). As Dr. Eisch departed UTSW for UPenn in the Summer of 2016, June 1, 2016 Matt joined lab of Lenora Volk at UTSW. Predoctoral trainees, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE (1) **diversity trainee 13) **Lyles R. Clark Joined Eisch Lab in March 2017. Member of UPenn Neuroscience Graduate Group. Summer 2018 designated a Hearst Summer Scholar.

POSTDOCTORAL TRAINEES (14 total) Postdoctoral trainees, UT SOUTHWESTERN MEDICAL CENTER (10) **diversity trainee 1) Chitra D. Mandyam, Ph.D. Received Ph.D. in Pharmacology from University of Houston in 2002. Was Eisch Laboratory postdoctoral fellow from February 2001 to June 2004. Earned individual National Research Service Postdoctoral Award from NIDA (F32 DA018017). In July 2004, earned an Assistant Professor position at the The Scripps Research Institute, San Diego, CA. Has received multiple K/R grants from NIH to support her independent laboratory.

2) Diane C. Lagace, Ph.D. Received Ph.D. in Pharmacology from Dalhouise University, Nova Scotia, Canada in July 2004. Was Eisch Laboratory postdoctoral fellow from September 2004 to January 2008. Earned individual postdoctoral research fellowship from Canadian Institute for Health Research (3 year grant).

30 Eisch, Amelia J. In February 2008, was promoted to Instructor at UT Southwestern Medical Center and received a Young Investigator Award from the National Alliance for Research on Schizophrenia and Depression (2 year grant). In January 2009, Dr. Lagace established her independent laboratory at the University of Ottawa/Ottawa Health Research Institute, Ottawa, Canada. Has received multiple competitive grants from the Canadian government to support her independent laboratory (NSERC, CIHR).

3) Stephanie J. Fischer, Ph.D. Received Ph.D. in Neuroscience from Mayo Clinic Graduate School, Rochester, MN in May 2002. Was Eisch Laboratory postdoctoral fellow from June 2005 to May 2007. Earned postdoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290). In June 2007, Dr. Fischer took a position leading 9th grade science and AP biology at the Booker T. Washington Creative Arts Magnet High School in the Dallas Independent School District. She is currently a faculty member in the Department of Biology, University of Texas, Tyler, Tyler, TX.

4) Madeleine A. Johnson, Ph.D. Received Ph.D. in Neuroscience from Columbia University, NY, NY in May 2008. Was Eisch Laboratory postdoctoral fellow from June 2008 to June 2010. Earned postdoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290). In 2010, received a merit-based scholarship to attend NYU School of Science Journalism. Science writer, genomeweb.com.

5) Neal R. Melvin, Ph.D. Received Ph.D. in Neuroscience from University of Lethbridge, Alberta, Canada in August 2008. Was Eisch Laboratory postdoctoral fellow from November 2008 to July 2010. Earned individual postdoctoral research fellowship from Alberta Heritage Medical Foundation. In August 2010, accepted an Assistant Professorship at Quest University in Canada.

6) David Petrik, Ph.D. Received Ph.D. in Neuroscience from UT Health Science Center at San Antonio in July 2008. Was Eisch Laboratory postdoctoral fellow from November 2008 through February 2013. In March 2013, joined the laboratory of Dr. Magdalena Götz, Helmholtz, Munich, Germany In 2019, joined

7) Irene Masiulus Bowen, Ph.D. Received Ph.D. in Integrative Biology from UT Southwestern in Spring 2009 (lab of Joachim Herz). Was Eisch Laboratory postdoctoral fellow from January 2010 to May 2012. Earned postdoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290). In 2012, was selected to be Manager of Quantitative Morphology Core, Department of Psychiatry, UT Southwestern Medical Center. Now faculty member, Collin College, McKinney, TX.

8) Sanghee Yun, Ph.D. Received Ph.D. from University of Utah in Neurobiology and Anatomy in December 2009 (lab of Ed Levine). Eisch Laboratory postdoctoral fellow from February 2011 – June 2016. Earned postdoctoral trainee position on NIMH institutional National Research Service Grant (T32 MH076690, 07/01/13 – present). Oct 1 2016, began position as Non-tenure Track Research Assistant Professor at University of Pennsylvania Perelman School of Medicine

9) **Sarah E. Latchney, Ph.D. Received Ph.D. in Environmental Toxicology, University of Rochester in November 2011 (lab of Lisa Opanashuk). Eisch Laboratory postdoctoral fellow from March 2012 – November 2015. Supported by a 1.75-year postdoctoral Diversity Supplement linked to Dr. Eisch’s grant entitled “Opiates and adult neurogenesis” (R01 DA016765) from NIH/NIDA, 9/15/12-04/30/14. Earned postdoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290, 05/01/15 – present). In 2015, accepted position as science/medical writer at Dava Oncology, Dallas, TX. In 2019, accepted tenure-track position as Assistant Professor of Biology and Neuroscience, St. Mary's College of Maryland, St. Mary’s City, MD. 31 Eisch, Amelia J. 10) Angela K. Walker, Ph.D. Received Ph.D. in Neuroscience, UT Southwestern Medical Center in April 2014 (lab of Jeffrey Zigman). Postdoctoral fellow from January 2015 – April 2016. Earned postdoctoral trainee position on NIDA institutional National Research Service Grant (T32 DA007290, beginning May 1 2015). In 2016, when Dr. Eisch moved to PennMed/CHOP, Dr. Walker opted to stay in Dallas and accepted position as postdoctoral fellow in the laboratory of Dr. Craig Powell, UT Southwestern Medical Center.

Postdoctoral trainees, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE (4) 11) Giulia Zanni, Ph.D. Received Ph.D. in Neuroscience in 2015 from the University of Gothenburg, Sweden (lab of Klas Blomgren). Postdoctoral fellow from March 2017 – May 2019. Moved to New York to pursue specific postdoctoral training in early life development.

12) Steven J. Simmons, Ph.D. Received Ph.D. in Neuroscience in June 2018 from the Temple University (lab of John Muschamp). Postdoctoral fellow from 29 June 2018 – present. Earned postdoctoral trainee position on NINDS-funding institutional National Research Service Grant, “Training Program in Neurodevelopmental Disabilities” (T32 NS007413, PI MB Robinson), 06/29/18 – present 13) Danielle G. Barber, M.D.-Ph.D. Received M.D.-Ph.D. from Yale University/NIDA (labs of Marina Picciotto and Bruce Hope) Postdoctoral fellow from July 2019 – present. Mentor: Amelia Eisch. Earned slot institutional postdoctoral National Research Service Grant (PIs Dichter and Jensen), effective 07/01/19 14) **Frederico C. Kiffer, Ph.D. Received Ph.D. in Pharmaceutical Sciences (Neuroscience Focus) from University of Arkansas for Medical Sciences April 13, 2019 (labs of Antonio Allen and Marjan Boerma). Postdoctoral fellow from July 2019 – present. Earned postdoctoral fellowship from the Translational Research Institute for Space Health (TRISH)/NASA. Mentor: Amelia Eisch.

INFORMAL MENTORING (attend Eisch Lab Meetings, meet with Eisch on regular basis) (2) Predoctoral Fellows Ruthie E. Wittenberg Member of John Dani’s Lab, informally co-mentored by Eisch. Member of UPenn Neuroscience Graduate Group. Postdoctoral Fellows Melinda Snitow, Ph.D. Received Ph.D. in Cell/Cellular and Molecular Biology in June 2015 from the University of Pennsylvania (lab of Edward E. Morrisey). Postdoctoral fellow from May 2016 – present. Mentor: Peter Klein. Earned individual postdoctoral National Research Service Grant, “Mechanism of lithium in neurogenesis and behavior” (F32 MH113334, PI ME Snitow), 03/15/18 – 03/14/21

UNDERGRADUATE TRAINEES (42 total) College attended and special honors or fellowships achieved for work is also noted. Undergraduate trainees, UT SOUTHWESTERN MEDICAL CENTER (24) **diversity trainee 1) Ryan Simonak (Rice University) Summer 2001 & 2002. Stanley Summer Scholar. 2) Lina Seikh (UT Austin) Summer 2003. Summer Undergraduate Research Fellow (SURF). 3) Amy Mahan (Trinity College) Summer 2005 (SURF). 4) Ricky Markus (UT Austin) Summer 2005. Summer Training in Drug Abuse Research (S-TDAR). 5) Stephen Bell (UT Dallas) Winter 2006 (UT Dallas Green Fellow). Opted not to complete program. For details 32 Eisch, Amelia J. of departure, contact Dr. Eisch or Dr. Nancy Street, Director of the UTSW SURF program. 6) David Pyle (Texas A&M) Summer 2006 (QP-SURF). 7) Josh Schonborn (Oberlin College) Summer 2006 & 2007 (S-TDAR fellow). 8) **Dante Gonzalez (St. Mary’s University) Summer 2007 (SURF). 9) Greg Wallingford (Notre Dame University) Summer 2007. 10) Jae Kwak (University of Michigan) Summer 2008, Summer 2011. 11) Moushumi Dey (Weslyan) Summer 2008 (SURF). 12) Ramya Raghavan (Austin College). Summer 2009 (SURF), Winter Independent Study 2010 (for credit at Austin College), Summer 2010 (SURF), throughout 2010-2011 school year for Austin College Capstone project. 13) Tahmina Mahmood (UT Dallas). Summer 2009 and volunteered throughout 2009-2010 academic year. 14)** Adam Carlton (Cornell University, UT Dallas). Summer 2010 (supported by NIDA Diversity Supplement from Eisch Opiate R01), and throughout the 2010-2012 school years. 15) Sohail Kamrudin (U Michigan). Summer 2010, Summer 2011. 16) Monica Tamil (UT Dallas) Winter-Spring 2011 (UT Dallas Green Fellow). 17) Rachel Redfield (University of Maryland) Fall 2011. 18) Alanna Just (Quest University) Summer 2012 (SURF). 19) Michael He (Rice University) Summer 2013. 20) **Emily Fernandez Garcia (University of Puerto Rico) Summer 2013 (SURF). 21) Bianca Siegel (Tulane University) Summer 2013 (SURF). Opted not to complete the 8-week program. For details of departure, contact Dr. Eisch or Dr. Nancy Street, Director of the UTSW SURF program. 22) Ryan Reynolds (UT Dallas) Spring 2014 (UT Dallas Green Fellow) and Summer 2014 (lab intern). 23) David Beddow (UT Dallas) Spring 2015 (UT Dallas Green Fellow). 24) Eric Kim (Texas A&M) Summer 2016. Undergraduate trainees, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE (18) **diversity trainee 25) Hannah Deutsch (U Penn) Summer 2017 – May 2019. 26) Adam Gibson (U Richmond) Summer 2017. 27) **Ivan Soler (Vassar) Summer 2017: PennMed SUIP (Summer Undergraduate Internship Program) fellow, and Summer 2018 – present: PENN PREP Post-baccalaureate Program. 28) **Nana K. Acquah (U Penn) January 2018 – present. 29) **Emmanuel Alvarez (Rowan U) Summer 2018: PennMed SUIP (Summer Undergraduate Internship Program) fellow. 30) Matt (Matty) Yuen (Dartmouth College) Summer 2018: CHOP Research Institute Summer Scholars Program (CRISSP) 31) Alex Zhou (U Penn) December 2018 – present. 32) Danny Kutsovsky (U Penn) December 2018 – present. 33) William Haury (U Penn) January 2019 – present. Summer 2019, volunteer. 34) Raena Greenbaum (U Penn) January 2019 – present. 35) **Marsha Edwards (U Penn) January 2019 – present. 36) **Ismail Ouddi (U Penn) February 2019 – May 2019. 37) Youvin Chang (U Penn) Ray and Diana Vagelos Life Sciences Trainee. April 2019 – present. 38) Priya Kumar (UPenn) Summer 2019. Penn Undergraduate Research Mentee (PURM). 39) Jordyn Schwartz (Dickinson College) Summer 2019, volunteer. 40) Dana Raphael (UPenn) Summer 2019. Penn Undergraduate Research Mentee (PURM). 41) **Rikley Costa Paixao (Philadelphia Community College) Summer 2019. CRISSP fellow. 42) **Catalina Guzman (Rutgers) Summer 2019 – present: PENN PREP Post-baccalaureate Program.

HIGH SCHOOL TRAINEES (31 total) Special high school programs attended and special honors or fellowships achieved for work is also noted. High school trainees, UT SOUTHWESTERN MEDICAL CENTER (28) **diversity trainee 1) Jessica Yee (Texas Academy of Math and Science student, or TAMS) Summer 2003 & 2004. Stanley Summer Scholar. 2) Emily Hsu (TAMS student) Summer 2004. Semi-finalist, Siemens Westinghouse Competition. 33 Eisch, Amelia J. 3) Sean Yue (TAMS student) Summer 2005. Semi-finalist, Siemens Westinghouse Competition. 4) Santhra Sebastian (TAMS student) Summer 2005. 5) Monica Lu (TAMS student) Summer 2005. Semi-finalist, Siemens Westinghouse Competition 6) Santhra Sebastian (TAMS student) Summer 2005. 7) Stephanie Rogan (Highland Park High School) Summer 2006 & 2007. 8) Angel Cook (DISD) Summer 2007. Student/Teacher Access to Resources at Southwestern (STARS). 9) Jason Wang (TAMS) Summer 2007. TAMS summer scholarship. 10) Lurit Bepo (TAMS) Summer 2007. 11) Amina Igeh (TAMS) Summer 2007. 12) Chandana Ravikumar (TAMS) Summer 2007. 13) Arathi Ramamurthi (TAMS) Summer 2007. 14) Harry Han (TAMS) Summer 2008. S-TDAR fellow. 15) Ramneek Manchanda (Carrollton High School) Summer 2008. 16) Allison Quast (TAMS) Summer 2008. 17) Xiafei Ye (TAMS). Summer 2008. 18) Ramya Raghavan (TAMS). Summer 2008. TAMS summer scholarship. 19) **Adam Carlton (Richardson High School). Winter 2008, Summer 2009. 20) Jim Chen (TAMS) Summer 2009. TAMS summer scholarship. 21) Sohail Kamrudin (TAMS). Summer 2009. 22) Erika Clark (TAMS). Summer 2010, Summer 2011 (as SURF student). SURF position generously supported by grant from Texas Initiative “Mechanisms of Disease and Translational Science” grant, PI Helen Yin, Ph.D. 23) Crystal Chen (Richardson High School). Summer 2010, Summer 2011. 24) Avanika Khanna (TAMS). Summer 2010. 25) Junho Ahn (TAMS). Summer 2011. 26) Ashesh Trivedi (Carroll Medical Academy). Summer 2012. 27) **Christopher Washington (UIC College Prep High School). Summer 2015. Physician Scientist Training Program (PSTP). 28) Uma Ramesh (TAMS). Summer 2016. High school trainees, UNIVERSITY OF PENNSYLVANIA PERELMAN SCHOOL OF MEDICINE (3) **diversity trainee 29) **Clarissa Fuentes (The Hockaday School). Summer 2017 and Summer 2018. STEM-PREP Program. 30) Aishwarya Vemulapalli (The Peddie School). Summer 2018. Research Science Signature Experience (EXP). 31) Eileen Yang (The Peddie School). Summer 2019. Research Science Signature Experience (EXP).

VISITING/SABBATICAL RESEARCHERS (3 total) UT SOUTHWESTERN MEDICAL CENTER (3) Spring 2008: Jannon Fuchs, Ph.D. Professor, Department of Biological Sciences, University of North Texas. Spring 2012: Andrew Naylor, Ph.D. Researcher, University of Gothenburg, Sweden. October 2012-March 2014: Naoki Ito, Ph.D. Assistant Professor, Kitasato University, Tokyo, Japan.

TECHNICAL STAFF (in progress)

Past: Mara Cole Matthew J. DeSalle Adam D. Gibson Laure Farnbauch Junie LeBlanc Melanie Lucero Shveta Malhotra Rebekah Norris Ryan P. Reynolds Devon R. Richardson 34 Eisch, Amelia J. Cindy P. Schwartz Maiko Suarez

Present: Kyung Jin Ahn (July 2018 – present) Hannah M. Deutsch (June 2019 – present) Fionya H. Tran (June 2018 – present)

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