9Th Annual Enhancing Neuroscience Diversity Through Undergraduate Research Education Experiences (ENDURE) Meeting
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Connections Opportunities
FY2O11Annual Report e m B r a C i n g opportunities M e M b e r s S e r v i n g t e C h n o l o g i e s o u t r e a c h M e M o r y T r a i n i n g SCIENCE D i s C o v e r y B r a i n R e s e a R c h v a l u e A d v o c A c y S u p p o r t i n g C i r C u i t i nternational m i s s i o n f u t u r e E v o l v i n g D y n a m i c a C tion Potential C o g n i t i o n f o s t e r i n g connections e m B r a C i n g opportunities f o s t e r i n g R e s e a R c h S e r v i n g o u t r e a c h SCIENCE E v o l v i n g B r Technologies v a l u e S u p p o r t i n g D y n a A d v o c A c y m i s s i o n I n t e r n a t I o n a l C i r C u i t f u t u r e M e M o r y C o g n i t i o n t r a i n i n g 2010-2011 Society for Neuroscience Council OFFICERS Susan G. -
Scientists Honored for Research Unveiling Molecular Machines the Month of May Brought the Good Prestigious Honors in Science
june 2012 volume 8, issue 3 Advancing Biomedical Science, Education, and Health Care Scientists honored for research unveiling molecular machines The month of May brought the good prestigious honors in science. On the Campylobacter, which together cause chains of amino acids are formed into news that two School of Medicine 29th, Arthur L. Horwich, m.d., was most of the world’s food-borne illness. three-dimensional, functional struc- scientists, each of whom have done named a winner of the Shaw Prize Galán’s group has thoroughly tures. Misfolded proteins have been pathbreaking work on molecular ma- in Life Science and Medicine, along characterized the Salmonella “needle implicated in many diseases, including chines involved in human disease, had with his longtime scientific col- complex,” a syringe-like organelle Alzheimer’s disease and amyotrophic received high honors for their research. laborator Franz-Ulrich Hartl, m.d., through which the bacterium injects lateral sclerosis (als). On May 1 Jorge E. Galán, ph.d., dr.med., of the Max Planck Institute bacterial proteins into host cells during In 1989, Horwich’s lab, in collabo- d.v.m., chair and Lucille P. Markey of Biochemistry in Germany. infection, modulating the function ration with Hartl and his postdoctoral Professor of Microbial Pathogenesis Galán is renowned for his research of those cells for its own advantage. mentor Walter Neupert m.d., ph.d., and professor of cell biology, was elect- on the cell biology, biochemistry, im- In 2004, Galán and colleagues used discovered a specialized protein in yeast ed a member of the National Academy munobiology, and structural biology of cryoelectron microscopy to visualize called Hsp60 that acts as a protein- of Sciences (nas), one of the most the bacterial pathogens Salmonella and the three-dimensional structure of the folding machine. -
Directvote Election: Candidate Bios
DirectVote Election: Candidate Bios Councilor Slot 2 Your Voting Status: Select 0 to 1 from below. Selected: 0 Vote For: Lisa Monteggia Lisa Monteggia Administrative Accomplishments: I have been involved in numerous administrative roles at UT Southwestern Medical Center, including Faculty Search Committees, membership in the Animal Resource Center advisory committee, Institutional Animal Care and Use Committee, Graduate Student Admissions committee, as well as the development of the Behavioral Core Facility. These opportunities have provided me with the skills and experience to deal with the needs and operations of basic science —in particular animal research— in a complex medical school campus. Degree, Institute, Year Earned: BS, University of Illinois-Urbana, 1989 MS, University of Illinois-Urbana, 1991 PhD, The Chicago Medical School, 1998 Postdoctoral fellow, Yale University, 1998-2000 Research Areas: My research interest is the molecular and cellular mechanisms underlying psychiatric disorders and neuropsychiatric treatment strategies. My laboratory studies two critical areas of translational brain research, mechanisms underlying antidepressant action and synaptic alterations that lead to the pathophysiology of the Rett syndrome. Our focus is on the role of synaptic plasticity mechanisms that may underlie these disorders and suggest potential targets for therapeutics. Current Position(s) at Your Current Institution: Ginny and John Eulich Professorship in Autism Spectrum Disorders, Professor of Neuroscience, UT Southwestern Medical -
NRIC 2014 Event Program
Event Program WEDNESDAY, SEPTEMBER 24 Nebraska EPSCoR: Advancing Nebraska Through Transformative Research & Workforce Development HILTON OMAHA epscor.nebraska.edu nric.nebraska.edu Message from the Nebraska EPSCoR Director Notes: Dear Participants, Welcome to the 2014 Nebraska Neuroscience Symposium. Research in the field of neuroscience continues to make dynamic discoveries, each advance yielding greater understanding of the brain: humanity’s principal resource for addressing the challenges and possibilities we face. Your interactions here are part of what moves this work forward. Nebraska EPSCoR is proud to host this gathering. EPSCoR—the Experimental Program to Stimulate Competitive Research—was created by the U.S. Congress to improve research infrastructure and capacity of a group of states. We work with research and education partners to enhance their capabilities and benefit Nebraska’s workforce development and economic growth. At today’s symposium—our 10th annual event and second devoted to neuroscience—we appreciate National Science Foundation funding in support of these important connections. Our speakers bring expertise from standout careers. We greatly value their presence and hope you enjoy the knowledge transfer and networking opportunities. F. Fred Choobineh, P.E., Ph.D. Director, Nebraska EPSCoR Table of Contents Agenda... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ..1 Morning Session.. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .2 Afternoon Session. 5 Poster -
Essential Role of Brain-Derived Neurotrophic Factor in Adult Hippocampal Function
Essential role of brain-derived neurotrophic factor in adult hippocampal function Lisa M. Monteggia*†, Michel Barrot*, Craig M. Powell*, Olivier Berton*, Victor Galanis*, Terry Gemelli*, Sven Meuth*, Andreas Nagy‡, Robert W. Greene*, and Eric J. Nestler* *Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9070; and ‡Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5 Edited by Floyd E. Bloom, The Scripps Research Institute, La Jolla, CA, and approved May 27, 2004 (received for review March 26, 2004) Brain-derived neurotrophic factor (BDNF) regulates neuronal de- specific enolase–tetracycline transcriptional activator (NSE– velopment and function. However, it has been difficult to discern tTA) line are on a BL6͞SJL ϫ ICR background, the TetOp-Cre its role in the adult brain in influencing complex behavior. Here, we are on an ICR background, and the floxed BDNF mice are on use a recently developed inducible knockout system to show that a BL6͞sv129 background. The NSE–tTA mice (14) and the deleting BDNF in broad forebrain regions of adult mice impairs TetOp-Cre mice (15, 16) were maintained as homozygotes then hippocampal-dependent learning and long-term potentiation. We crossed to generate the bigenic mice. The floxed LacZ reporter use the inducible nature of this system to show that the loss of mice (17) or floxed BDNF mice (13) were then crossed with the BDNF during earlier stages of development causes hyperactivity bigenic NSE–tTA͞TetOp-Cre mice to generate the inducible and more pronounced hippocampal-dependent learning deficits. KO mice. All experiments were performed on littermates de- We also demonstrate that the loss of forebrain BDNF attenuates rived from this mating paradigm to ensure analysis by matched the actions of desipramine, an antidepressant, in the forced swim controls. -
Jean-Pierre G. Changeux
EDITORIAL ADVISORY COMMITTEE Marina Bentivoglio Larry F. Cahill Stanley Finger Duane E. Haines Louise H. Marshall Thomas A. Woolsey Larry R. Squire (Chairperson) The History of Neuroscience in Autobiography VOLUME 4 Edited by Larry R. Squire ELSEVIER ACADEMIC PRESS Amsterdam Boston Heidelberg London New York Oxford Paris San Diego San Francisco Singapore Sydney Tokyo This book is printed on acid-free paper. (~ Copyright 9 byThe Society for Neuroscience All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail: [email protected]. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting "Customer Support" and then "Obtaining Permissions." Academic Press An imprint of Elsevier 525 B Street, Suite 1900, San Diego, California 92101-4495, USA http ://www.academicpress.com Academic Press 84 Theobald's Road, London WC 1X 8RR, UK http://www.academicpress.com Library of Congress Catalog Card Number: 2003 111249 International Standard Book Number: 0-12-660246-8 PRINTED IN THE UNITED STATES OF AMERICA 04 05 06 07 08 9 8 7 6 5 4 3 2 1 Contents Per Andersen 2 Mary Bartlett Bunge 40 Jan Bures 74 Jean Pierre G. Changeux 116 William Maxwell (Max) Cowan 144 John E. Dowling 210 Oleh Hornykiewicz 240 Andrew F. -
LISA M. MONTEGGIA, Ph.D
LISA M. MONTEGGIA, Ph.D. RANK/TITLE: Barlow Family Director of the Vanderbilt Brain Institute Professor, Department of Pharmacology Address: Vanderbilt University MRBIII, Suite 7140 465 21st Avenue South Nashville, TN 37240-7933 PH: (615) 936-5483 FX: (615) 6936-3613 EM: [email protected] EDUCATION: University of Illinois, Urbana, IL – B.S.- Microbiology – 1989 University of Illinois, Urbana, IL – M.S. – Biology – 1991 The Chicago Medical School, North Chicago, IL – Ph.D. – Neuroscience – 1999 (Dr. Marina Wolf, PI) POSTDOCTORAL TRAINING: 1998-2000 Department of Psychiatry (Dr. Eric Nestler, PI) Yale University, New Haven, CT OTHER TRAINING: 1991-1994 Associate Scientist, Department of Neuroscience, Abbott Laboratories, Abbott Park, IL 1994-1998 Scientist, Department of Neuroscience, Abbott Laboratories, Abbott Park, IL ACADEMIC APPOINTMENTS: 09/2000-10/2002 Research Assistant Professor, Department of Psychiatry, UT Southwestern, Dallas, TX 10/2002-09/2009 Assistant Professor, Department of Psychiatry, UT Southwestern, Dallas, TX 09/2009-09/2013 Associate Professor (tenure), Department of Psychiatry, UT Southwestern, Dallas, TX 06/2010-06/2018 Ginny and John Eulich Professorship in Autism Spectrum Disorders 09/2013-06/2018 Professor, Department of Neuroscience, UT Southwestern, Dallas, TX 07/2018- Director, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 07/2018- Professor of Pharmacology, Vanderbilt University, Nashville, TN AWARDS/HONORS: 1985-1989 University of Illinois, Full Academic Tuition Scholarship 1991 Top 10% of Teaching Assistants for Excellence in Teaching, University of Illinois 1998-2000 NIH/NIDA Postdoctoral Training Grant, Yale University 2001 Young Investigator Award, NARSAD 2002 American College of Neuropsychopharmacology/Bristol-Myers Squibb Travel Award 2003 Developmental Neurobiology and Child Psychiatry, Otsuka Travel Award 2003 College on Problems on Drug Dependence, Center for Addictive Diseases Travel Award 2003 Young Investigator Award, NARSAD 2005 Daniel X. -
Anxiety-Related Interventions in Rodent Defense Behaviors
bioRxiv preprint doi: https://doi.org/10.1101/020701; this version posted November 18, 2015. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Anxiety-related interventions in rodent defense behaviors: systematic review and meta-analyses Authors Farhan Mohammad1, Joses Ho2, Chun Lei Lim, Jia Hern Woo, Dennis Jun Jie Poon2, Bhumika Lamba2 & Adam Claridge-Chang1, 2, 3, 4 Affiliations 1. Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore 138673 2. Institute for Molecular and Cell Biology, Agency for Science Technology and Research, Singapore 138673 3. Department of Physiology, National University of Singapore, Singapore 138673 4. Corresponding author: [email protected] Keywords anxiety, defense, behavior, rodent, stress, serotonin, meta-analysis 1 bioRxiv preprint doi: https://doi.org/10.1101/020701; this version posted November 18, 2015. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. ABSTRACT Background Assays measuring defense behavior in rodents, including the elevated plus maze, open field and light-dark box assays, have been widely used in preclinical models of anxiety to study the ability of therapeutic interventions to modulate the anxiety-like state. However, many important proposed anxiety-modulating factors, including genes, drugs and stressors have had paradoxical effects in these assays across different studies. -
Joshua T. Vogelstein –
Joshua T. Vogelstein, Ph.D., Assistant Professor, JHU – Curriculum Vitae 2021/09/23 Assistant Professor, Department of Biomedical Engineering Johns Hopkins University B [email protected] Joshua T. Vogelstein Í jovo.me Personal Information Primary Appointment 08/14 – Assistant Professor, Department of Biomedical Engineering, JHU, Baltimore, MD, USA. Joint Appointments 09/19 – Joint Appointment, Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA. 08/15 – Joint Appointment, Department of Applied Mathematics and Statistics, JHU, Baltimore, MD, USA. 08/14 – Joint Appointment, Department of Neuroscience, JHU, Baltimore, MD, USA. 08/14 – Joint Appointment, Department of Computer Science, JHU, Baltimore, MD, USA. Institutional and Center Appointments 08/15 – Steering Committee, Kavli Neuroscience Discovery Institute (KNDI), Baltimore, MD, USA. 08/14 – Core Faculty, Institute for Computational Medicine, JHU, Baltimore, MD, USA. 08/14 – Core Faculty, Center for Imaging Science, JHU, Baltimore, MD, USA. 08/14 – Assistant Research Faculty, Human Language Technology Center of Excellence, JHU, Balti- more, MD, USA. 10/12 – Affiliated Faculty, Institute for Data Intensive Engineering and Sciences, JHU, Baltimore, MD, USA. Education & Training 2003 – 2009 Ph.D in Neuroscience, Johns Hopkins School of Medicine, Advisor: Eric Young, Thesis: OOPSI: a family of optical spike inference algorithms for inferring neural connectivity from population calcium imaging . 2009 – 2009 M.S. in Applied Mathematics & Statistics, Johns Hopkins University. 1998 – 2002 B.A. in Biomedical Engineering, Washington University, St. Louis. Academic Experience 08/18 – Director of Biomedical Data Science Focus Area, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. 05/16 – Visiting Scientist, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA. -
The Receptors
The Receptors Volume 26 Series Editor Giuseppe Di Giovanni Department of Physiology & Biochemistry Faculty of Medicine and Surgery, University of Malta, Malta. The Receptors book Series, founded in the 1980’s, is a broad-based and wellrespected series on all aspects of receptor neurophysiology. The series presents published volumes that comprehensively review neural receptors for a specifi c hormone or neurotransmitter by invited leading specialists. Particular attention is paid to in-depth studies of receptors’ role in health and neuropathological processes. Recent volumes in the series cover chemical, physical, modeling, biological, pharmacological, anatomical aspects and drug discovery regarding different receptors. All books in this series have, with a rigorous editing, a strong reference value and provide essential up-to-date resources for neuroscience researchers, lecturers, students and pharmaceutical research. More information about this series at http://www.springer.com/series/7668 Robin A.J. Lester Editor Nicotinic Receptors Editor Robin A.J. Lester Department of Neurobiology University of Alabama at Birmingham Birmingham , AL , USA ISBN 978-1-4939-1166-0 ISBN 978-1-4939-1167-7 (eBook) DOI 10.1007/978-1-4939-1167-7 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014947538 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. -
An in Vitro Characterization of the Raphe Nucleus and the Effects of Ssris on Synaptic Function
AN IN VITRO CHARACTERIZATION OF THE RAPHE NUCLEUS AND THE EFFECTS OF SSRIS ON SYNAPTIC NEUROTRANSMISSION APPROVED BY SUPERVISORY COMMITTEE ________________________________________ Ilya Bezprozvanny, Ph.D. ________________________________________ Lisa Monteggia, Ph.D. ________________________________________ Joseph Albanesi, Ph.D ________________________________________ Melanie Cobb, Ph.D ________________________________________ Ege Kavalali, Ph.D Dedicated to my parents, Funke and Bashir Ashimi, my sister Laide and brother Idris, future husband Taofeek, and the rest of my family and friends for all their unconditional love and continued support. AN IN VITRO CHARACTERIZATION OF THE RAPHE NUCLEUS AND THE EFFECTS OF SSRIS ON SYNAPTIC NEUROTRANSMISSION By SUNBOLA SHEFIAT ASHIMI DISSERTATION Presented to the Faculty of the Graduate School of Biomedical Sciences The University of Texas Southwestern Medical Center at Dallas In Partial Fulfillment of the Requirements For the Degree of DOCTOR OF PHILOSOPHY The University of Texas Southwestern Medical Center at Dallas Dallas, Texas June 2010 Copyright by Sunbola Shefiat Ashimi, 2010 All Rights Reserved ACKNOWLEDGEMENTS I would like to thank Dr. Lisa Monteggia for her mentorship, support, and friendship over the past five years. I would also like to thank Dr. Ege Kavalali for his guidance and teaching me about the wonderful world of synaptic transmission. Regards to the past and present members of the Monteggia lab for their continued support, especially Erika Nelson, Megumi Adachi, and Waseem Akhtar for their training, scientific advice, and friendship. I want to thank Anita Autry for being such a wonderful and gracious friend to have taken this journey with. Also, I thank Melissa Mahgoub for her treasured friendship and for reminding me that there are still special people in the world. -
Eisch CV 083119 Webpage
Amelia J. Eisch, Ph.D. Curriculum Vitae, 31 August 2019 Tenured Professor Mail address: Abramson Research Center University of Pennsylvania Perelman School of Medicine (PennMed) and Room 402F Children's Hospital of Philadelphia (CHOP) Research Institute 3615 Civic Center Blvd. Email: [email protected], [email protected], Philadelphia, PA 19104-4318 or [email protected] Physical address: 68 Osler Circle Office telephone: (215) 590-1931 Philadelphia, PA 19104 EDUCATION Yale University, New Haven, CT 1986-1990 Bachelor of Arts in Psychology with Biology Track, cum laude University of California at Irvine, Irvine, CA 1990-1997 Doctor of Philosophy in Biological Sciences, received June 1997 Department of Psychobiology Yale University Medical School, New Haven, CT 1997-2000 Department of Psychiatry Postdoctoral Fellowship RESEARCH EXPERIENCE AND EMPLOYMENT UnderGraduate Research, Advisor, Dr. Richard J. Gerrig 1988-1989 Department of Psychology, Yale University: Memory retrieval during language comprehension UnderGraduate Research, Advisor, Dr. J. Steve Reznick 1988-1989 Department of Psychology, Yale University: Shyness in infant twins UnderGraduate Honors Research Thesis, Advisor, Dr. Mark A. Riddle 1989-1990 Child Study Center, Yale University Medical Center Socioeconomic impact on symptomatology in Gilles de la Tourette’s syndrome Doctoral Thesis, Research, and TeachinG Assistant, Advisor, Dr. John F. Marshall 1990-1997 Department of Psychobiology, University of California at Irvine Neuronal consequences of repeated administration of