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Early Intervention QuarterlyThe Spring 2013 RESEARCHNEWS 2 RESEARCH DISCOVERIES IN THE NEWS 5 INTERVIEW WITH A RESEARCHER Judith N. Rapoport, M.D. 7 DIAGNOSTIC TOOLS FOR YOUTHS David Shaffer, M.D. 8 FREQUENTLY ASKED QUESTIONS ON EARLY INTERVENTION 10 SUICIDE PREVENTION John J. Mann, M.D. 13 NARSAD INDEPENDENT INVESTIGATOR GRANTS 40 exceptional researchers with a variety of new approaches to understand and treat mental illness 20 NEW TREATMENTS 24 GLOSSARY Page 5 FEATURES 11 A FAMILY STORY FOCUS Well Into Recovery from Schizoaffective Disorder on 22 WOMEN’S MENTAL HEALTH CONFERENCE: EARLY Two Presentation Summaries INTERVENTION Scientific “The Brain & Behavior Research Foundation Scientific Council has grown to include 138 volunteer members, each of whom Council bring special skills and unique knowledge bases that cover every aspect of brain and behavior research. The reach of the Brain & Beha vior Research Foundation support extends to the world's leading medical research and care facilities. Our effort knows no borders. The impact of our effort is not only in the development of promising scientists, but also in the focus it brings to the challenge and urgent need of bringing hope and better lives to all those living with mental illness.” Herbert Pardes, M.D. President, Scientific Council President Executi ve Vice Chairman of the Board of Trustees, Herbert Pardes, M.D. NewYork-Presbyterian Hospital Vice President Emeritus Floyd E. Bloom, M.D. George K. Aghajanian, M.D. Frederick K. Goodwin, M.D. James H. Meador-Woodruff, M.D. Schahram Akbarian, M.D., Ph.D. Joshua A. Gordon, M.D., Ph.D. Herbert Y. Meltzer, M.D. Huda Akil, Ph.D. Anthony A. Grace, Ph.D. Richard J. Miller, Ph.D. Susan G. Amara, Ph.D. Paul Greengard, Ph..D Karoly Mirnics, M.D. Stewart A. Anderson, M.D. Elizabeth Gould, Ph.D. Bita Moghaddam, Ph.D. Nancy C. Andreasen, M.D., Ph.D. Suzanne N. Haber, Ph.D. Dennis L. Murphy, M.D. Amy F.T. Arnsten, Ph.D. Philip D. Harvey, Ph.D. Charles B. Nemeroff, M.D., Ph.D. Jay M. Baraban, M.D., Ph.D. Stephan Heckers, M.D. Eric J. Nestler, M.D., Ph.D. Jack D. Barchas, M.D. René Hen, Ph.D. Andrew A. Nierenberg, M.D. Samuel H. Barondes, M.D. Fritz A. Henn, M.D., Ph.D. Patri cio O'Donnell, M.D., Ph.D. Francine Mary Benes, M.D., Ph.D. Robert M.A. Hirschfeld, M.D. Steven M. Paul, M.D. Wade H. Berrettini, M.D., Ph.D. Steven E. Hyman, M.D. Godfrey D. Pearlson, M.D. Randy D. Blakely, Ph.D. Robert B. Innis, M.D., Ph.D. Daniel S. Pine, M.D. Pierre Blier, M.D., Ph.D. Jonathan A. Javitch, M.D., Ph.D. Robert M. Post, M.D. Robert W. Buchanan, M.D. Daniel C. Javitt, M.D., Ph.D. James B. Potash, M.D., M.P.H. Peter F. Buckley, M.D. Lewis L. Judd, M.D. Steven G. Potkin, M.D. William E. Bunney, Jr., M.D. Peter W. Kalivas, Ph.D. Pasko Rakic, M.D., Ph.D. Joseph D. Buxbaum, Ph.D. Eric R. Kandel, M.D. Judith L. Rapoport, M.D. William F. Byerley, M.D. Richard S.E. Keefe, Ph.D. Perry F. Renshaw, M.D., Ph.D., M.B.A. Marc G. Caron, Ph.D. Samuel J. Keith, M.D. Kerry J. Ressler, M.D., Ph.D. William T. Carpenter, Jr., M.D. Martin B. Keller, M.D. Carolyn B. Robinowitz, M.D. Cameron S. Carter, M.D. John R. Kelsoe, M.D. Bryan L. Roth, M.D., Ph.D. BJ Casey, Ph.D. Kenneth S. Kendler, M.D. John L. R. Rubenstein, M.D., Ph.D. Dennis S. Charney, M.D. James L. Kennedy, M.D. Bernardo Sabatini, M.D., Ph.D. Bruce M. Cohen, M.D., Ph.D. Robert M. Kessler, M.D. Elaine Sande rs-Bush, Ph.D. Jonathan D. Cohen, M.D., Ph.D. Kenneth K. Kidd, Ph.D. Akira Sawa, M.D., Ph.D. Richard Coppola, D.Sc. Mary-Claire King, Ph.D. Alan F. Schatzberg, M.D. Joseph T. Coyle, M.D. Rachel G. Klein, Ph.D. Nina R. Schooler, Ph.D. Jacqueline N. Crawley, Ph.D. John H. Krystal, M.D. Robert Schwarcz, Ph.D. Karl Deisseroth, M.D., Ph.D. Francis S. Lee, M.D., Ph.D. Philip Seeman, M.D., Ph.D. J. Raymond DePaulo, Jr., M.D. James F. Leckman, M.D. Solomon H. Snyder, M.D., D.Sc., D.Phil. Ariel Y. Deutch, Ph.D. Ellen Leibenluft, M.D. (Hon. Causa) Wayne C. Drevets, M.D. Robert H. Lenox, M.D. John S. Strauss, M.D. Ronald S. Duman, Ph.D. David A. Lewis, M.D. John David Sweatt, Ph.D. Jan A. Fawcett, M.D. Jeffrey A. Lieberman, M.D. John A. Talbott, M.D. Stan B. Floresco, Ph.D. Irwin Lucki, Ph.D. Carol A. Tamminga, M.D. Judith M. Ford, Ph.D. Robert C. Malenka, M.D., Ph.D. Laurence H. Tecott, M.D., Ph.D. Alan Frazer, Ph.D. Anil K. Malhotra, M.D. Ming T. Tsuang, M.D., Ph.D., D.Sc. Robert R. Freedman, M.D. Husseini K. Manj i, M.D., FRCPC Leslie G. Ungerleider, Ph.D. Fred H. Gage, Ph.D. J. John Mann, M.D. Rita J. Valentino, Ph.D. Aurelio Galli, Ph.D. John S. March, M.D., M.P.H. Nora D. Volkow, M.D. Mark S. George, M.D. Helen S. Mayberg, M.D. Mark E. von Zastrow, M.D., Ph.D. Elliot S. Gershon, M.D. Robert W. McCarley, M.D. Karen Dineen Wagner, M.D., Ph.D. Mark A. Geyer, Ph.D. Bruce S. McEwen, Ph.D. Daniel R. Weinberger, M.D. Jay Adam Gingrich, M.D., Ph.D. Paul R. McHugh, M.D. Jon-Kar Zubieta, M.D., Ph.D. David Goldman, M.D., Ph.D. Ronald McKay, Ph.D. Board of Directors Dear Members of Our Foundation Community, OFFICERS Chairman All of us who are concerned with questions of mental Stephen A. Lieber health know that neuropsychiatric research is flourishing. New technologies are opening new vistas to understand- Vice President Suzanne Golden ing the brain and neuroscientists working across disci- plines and across borders are taking new approaches to Secretary improve available treatments. The once far-flung vision of John B. Hollister prevention and cure is within our sight. We are all also Treasurer keenly aware of gaps in how much is understood about Arthur Radin, CPA the brain, how and when to appropriately intervene to treat its illnesses and how to recognize early on what is becoming a serious mental health issue. DIRECTORS Anne E. Abramson Mark H. Alcott, Esq. Tragedies such as that in Newtown, CT last December have intensified aware- J. Anthony Boeckh ness of this gap as well as the public dialogue around mental illness. Our point Bonnie D. Hammerschlag of view is tha t accelerating funding for neuropsychiatric research needs to be George B. Handran, Esq. Ken Harrison a part of this conversation. With increased focus on understanding what Carole Mallement causes mental illness and identifying early warning signs, we will be able to Milton Maltz intervene before the illnesses progress to a state where they are much more Hon. Sue Myrick difficult to treat. And even more importantly, with effective early intervention, Marc R. Rappa port Barbara K. Streicker we should be able to reduce the occurrence of untreated mental illness, which Robert S. Warshaw, Esq. sometimes presents a risk of violence—whether it is violence of the patient Robert Weisman, Esq. toward him/herself or toward others. EX-OFFICIO President & CEO The projects of some of the scientists the Foundation has funded through Jeffrey Borenstein, M.D. its NARSAD Grants for work on developing diagnostic and early intervention techniques are described in this issue of The Quarterly. Not surprisingly, a President, Scientific Council Herbert Pardes, M.D. number of these studies are focused on children and young people; exciting new methods are being explored aimed at recognizing and treating mental President Emerita illnesses as early as possible so as to lessen their escalating impact over time. Constance E. Lieber It goes without saying that the Foundation’s ability to fund these and many other important advances in neuroscience depends on our donors. I have been very moved over the past several months as I have stepped into the role The as the new President and CEO of the Foundation to observe at first hand the Quarterly dedication of our donors. The level of passion and commitment to find real CREDITS: answers to the complex issues presented by mental illness is quite remarkable. Writers: It is a passion shared by the researchers we fund, and together we are making Judith N. Schwartz significant progress. With thousands of NARSAD Grantees work ing everyday to Peter Tarr, Ph.D. find solutions, we are continually progressing to improve the lives of those still Editors: suffering with these illnesses. As the new leader of this Foundation, I commit Laura C. Wells, to pursuing the funding to accelerate the rate of research and keeping you Vice President, abreast of the significant and exciting progress being made. Marketing and Communications Elizabeth Reinish With your continued support of the cutting edge research we fund, we can get to soluti ons we need—for this generation and the next. Layout/Design: Lorraine Divone Production and Art Director Sincerely, On the Cover: Judith L. Rapoport, M.D. Jeffrey Borenstein, M.D. President & CEO bbrfoundation.org 1 Research Discoveries in the News Research Discoveries in the News Landmark Study Shows Common Genetic Links Across 5 Major Psychiatric Disorders Jordan W.
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