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Bromomethane CAS #: 74-83-9 Revised By: RRD Toxicology Unit Revision Date: August 14, 2015

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Bromomethane CAS #: 74-83-9 Revised By: RRD Toxicology Unit Revision Date: August 14, 2015 CHEMICAL UPDATE WORKSHEET Chemical Name: Bromomethane CAS #: 74-83-9 Revised By: RRD Toxicology Unit Revision Date: August 14, 2015 (A) Chemical-Physical Properties Part 201 Value Updated Value Reference Source Comments Molecular Weight (g/mol) 94.94 94.94 EPI EXP Physical State at ambient temp Liquid Gas MDEQ Melting Point (˚C) 179 -93.70 EPI EXP Boiling Point (˚C) 3.5 3.50 EPI EXP Solubility (ug/L) 1.45E+7 1.52E+07 EPI EXP Vapor Pressure (mmHg at 25˚C) 1672 1.62E+03 EPI EXP HLC (atm-m³/mol at 25˚C) 1.42E-2 7.34E-03 EPI EXP Log Kow (log P; octanol-water) 1.18 1.19 EPI EXP Koc (organic carbon; L/Kg) 14.5 13.22 EPI EST Ionizing Koc (L/kg) NR NA NA Diffusivity in Air (Di; cm2/s) 0.08 1.00E-01 W9 EST Diffusivity in Water (Dw; cm2/s) 8.0E-6 1.3468E-05 W9 EST CHEMICAL UPDATE WORKSHEET Bromomethane (74-83-9) Part 201 Value Updated Value Reference Source Comments Soil Water Partition Coefficient NR NR NA NA (Kd; inorganics) Flash Point (˚C) NA 194 PC EXP Lower Explosivity Level (LEL; 0.1 0.1 CRC EXP unit less) Critical Temperature (K) 467.00 EPA2004 EXP Enthalpy of Vaporization 5.71E+03 EPA2004 EXP (cal/mol) Density (g/mL, g/cm3) 1.6755 CRC EXP EMSOFT Flux Residential 2 m 2.69E-05 2.80E-05 EMSOFT EST (mg/day/cm2) EMSOFT Flux Residential 5 m 6.53E-05 6.86E-05 EMSOFT EST (mg/day/cm2) EMSOFT Flux Nonresidential 2 m 3.83E-05 4.47E-05 EMSOFT EST (mg/day/cm2) EMSOFT Flux Nonresidential 5 m 9.24E-05 1.09E-04 EMSOFT EST (mg/day/cm2) 2 CHEMICAL UPDATE WORKSHEET Bromomethane (74-83-9) (B) Toxicity Values/Benchmarks Source/Reference/ Comments/Notes Part 201 Value Updated Value Date /Issues Reference Dose 1.4E-3 2.0E-2 OPP, 2013 (RfD) (mg/kg/day) Rat subchronic Tier 1 Source: Complete gavage study EPA-OPP: (Danse et al., Basis: OPP is the more current than IRIS, PPRTV and ATSDR. 1984); NOAEL=1.4 OPP chronic RfD = 0.022 mg/kg-day. mg/kg/day. Critical Study: Mertens, J. (1997) A 24-Month Chronic Dietary Study of Methyl UF=1000. Bromide in Rats: Final Report: Lab Project Number: WIL-49014. Unpublished study Critical effect = prepared by WIL Research Labs., Inc. 4972p. (44462501) epithelial Method(s): In a combined chronic toxicity/carcinogenicity study (MRID hyperplasia of the 44462501), microencapsulated methyl bromide was administered to 4 groups of forestomach. male and female Crl:CD®(SD)BR rats for a period of 12 or 24 months (interim and main study, respectively) in the diet at concentrations of 0 (diet control), 0 Entry date: (placebo control), 0.5, 2.5, 50, or 250 ppm (equivalent to 0, 0.02, 0.11, 2.20 and 5/26/1988 11.10 mg/kg/day in males and 0, 0.03, 0.15, 2.92 and 15.12 mg/kg/day in females. Groups of 50 males and 50 females were designated for the main study RfD details and were treated for up to 104 weeks. Groups of 20 males and 20 females were sacrificed at 52 weeks in the diet control, placebo control, 50 ppm group and the 250 ppm group. Critical effect: decreased body weight gain and food consumption in males End point or Point of Departure (POD): NOAEL = 2.2 mg/kg-day (50 ppm) for males Uncertainty Factors: UF = 100 (10 each for intraspecies variability and interspecies extrapolation) Source and date: EPA-OPP, 9/13/2013. IRIS (2015) refers to OPP for toxicity updates of methylbromide. Tier 1 and 2 Sources: EPA:OPP: Other OPP values: Per EPA-OPP (9/13/2013), 1) acute RfD for females ages 13-50 years = 0.014 (1.4E-2) mg/kg-day: 3 CHEMICAL UPDATE WORKSHEET Bromomethane (74-83-9) Source/Reference/ Comments/Notes Part 201 Value Updated Value Date /Issues Critical Study (ies): Breslin, W.; Zablotny, C.; Bradley, G. (1990) Methyl Bromide Inhalation Teratology Study in New Zealand White Rabbits: Lab Project Number: K-000681-033. Unpublished study prepared by The Dow Chemical Co. 362 p. (41580401) Method(s): rabbit developmental study: pregnant New Zealand White rabbits (26 animals/dose) were exposed by whole body inhalation to 0, 20, 40 or 80 ppm MeBr vapor for 6 hr./day on Days 6-16 of gestation. Mating was conducted using artificial insemination. Critical effect: developmental toxicity – agenesis (absence) of the gall bladder in the fetus and increased incidence of fused sternebrae End point or Point of Departure (POD): NOAEL = 40 ppm (14 mg/kg-day) Uncertainty Factors: UF = 100 (10 each for intraspecies variability and interspecies extrapolation); FQPA SF = 1X 2) acute RfD for general population including infants and children = 0.9 mg/kg-day: Critical Study (ies): Driscoll, C.; Hurley, J. (1993) Methyl Bromide: Single Exposure Vapor Inhalation Neurotoxicity Study in Rats: Lab Project Number: 92N1197. Unpublished study prepared by Union Carbide, 558 p. May 27, 1993. (42793601), Method(s): acute rat neurotoxicity study: CD rats (15 rats/sex/dose) were exposed by whole body inhalation to 0, 30, 100 or 350 ppm MeBr vapor for 6 hours (equivalent to males: 0, 27, 90 or 314 mg/kg/day and females: 0, 30, 101, or 354 mg/kg/day). Critical effect: decreased activity, increase in number of animals with drooping/half-closed eyelids and alertness, decreased rears, decreased motor activity, increased piloerection and decreased body temperature End point or Point of Departure (POD): NOAEL = 100 ppm (90 mg/kg-day) Uncertainty Factors: UF = 100 (10 each for intraspecies variability and interspecies extrapolation); FQPA SF = 1X 4 CHEMICAL UPDATE WORKSHEET Bromomethane (74-83-9) Source/Reference/ Comments/Notes Part 201 Value Updated Value Date /Issues IRIS: Per IRIS (7/1/1991), RfD = 1.4E-3 mg/kg-day Critical Study: Danse, L.H.J.C., F.L. van Velsen and C.A. van der Heijden. 1984. Methylbromide: Carcinogenic effects in the rat forestomach. Toxicol. Appl. Pharmacol. 72: 262-271). Method(s): Wistar rats (10/sex/dose) were exposed to 0, 0.4, 2, 10, or 50 mg/kg by gavage for 5 days/week for 13 weeks Critical effect: epithelial hyperplasia in the forestomach End point or Point of Departure (POD): NOAEL = 2.0 mg/kg; schedule-adjusted NOAEL = 1.4 mg/kg/day Uncertainty Factors: UF = 1,000 (10 each for intraspecies variability, interspecies extrapolation and use of a subchronic study) Source and date: IRIS, Last revision date - 7/1/1991. An IRIS screening-level review in 2001 identified one or more significant new studies. PPRTV: Per PPRTV (6/5/2007), subchronic p-RfD = 5.0E-3 mg/kg-day Critical Study: Danse, L.H.J.C., F.L. van Velsen and C.A. van der Heijden. 1984. Methylbromide: Carcinogenic effects in the rat forestomach. Toxicol. Appl. Pharmacol. 72: 262-271). Method(s): Wistar rats (10/sex/dose) were exposed to 0, 0.4, 2, 10, or 50 mg/kg by gavage for 5 days/week for 13 weeks Critical effect: forestomach hyperplasia in rats End point or Point of Departure (POD): NOAEL = 2 mg/kg; NOAEL(ADJ) = 1.4 mg/kg-day Uncertainty Factors: UF = 300 (10 each for intraspecies variability and interspecies extrapolation, and 3 for database deficiencies) Source and date: PPRTV, 6/5/2007 MRL: Per ATSDR (9/1992), no chronic oral MRL at this time. An oral intermediate MRL = 0.003 mg/kg-day is available: From 4/2015 MRL list. Critical Study (ies): Danse, L.H.J.C., F.L. van Velsen and C.A. van der Heijden. 1984. Methylbromide: Carcinogenic effects in the rat forestomach. Toxicol. Appl. 5 CHEMICAL UPDATE WORKSHEET Bromomethane (74-83-9) Source/Reference/ Comments/Notes Part 201 Value Updated Value Date /Issues Pharmacol. 72: 262-271). Method(s): Bromomethane was administered to Wistar rats (10/sex/dose) by gavage 5 days/week for 13 weeks at 0, 0.4, 2, 10, or 50 mg/kg. Critical effect: hyperplasia and ulcers End point or Point of Departure (POD): adjusted NOAEL = 0.4 mg/kg-day Uncertainty Factors: UF = 100 (10 each for intraspecies variability and interspecies extrapolation) Tier 3 Source: MDEQ: Per DEQ-CCD/RRD (5/26/1988), RfD = 1.4E-3 mg/kg-day. See Part 201 RfD details. Oral Cancer Slope Factor (CSF) -- NA MDEQ, 2015 (mg/kg-day)-1) Tier 1 and 2 Sources: IRIS: Per IRIS (1989), bromomethane is classified as D (not classifiable as to human carcinogenicity) based on inadequate human and animal data: a single mortality Complete study from which direct exposure associations could not be deduced and studies in several animal species with too few animals, too brief exposure or observation time for adequate power. EPA-OPP: Per OPP (2013), methyl bromide is classified as “Not Likely to be Carcinogenic to Humans" based on a weight of evidence evaluation of the toxicity NA CSF details database including no indications of carcinogenesis observed in the chronic rodent bioassays. PPRTV: Per PPRTV (6/05/07), there is inadequate information to assess the carcinogenic potential of bromomethane in humans. MRL: NA; MRLs are for non-cancer effects only. Tier 3 Source: MDEQ: Per DEQ-CCD, no value at this time. Reference Concentration 5.0E+0 1.0E+1 PPRTV, 2007 (RfC) or Initial 6 CHEMICAL UPDATE WORKSHEET Bromomethane (74-83-9) Source/Reference/ Comments/Notes Part 201 Value Updated Value Date /Issues Threshold Screening Level (ITSL) (µg/m³) Tier 2 Source: PPRTV: Basis: PPRTV (6/5/2007) is the more current than IRIS.
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