Clinical Aspects of Aconitum Preparations*
Reviews 1017 Clinical Aspects of Aconitum Preparations* Authors Chi-Jung Tai1,3 #, Mohamed El-Shazly1, 2 #, Tung-Ying Wu4, Kun-Tai Lee5, 6, Dezső Csupor 7, Judit Hohmann7, Fang-Rong Chang1, 8,9, 10, Yang-Chang Wu1,4, 11,12 Affiliations The affiliations are listed at the end of the article Key words Abstract tion has changed with the application of new l" Aconitum ! technologies for the accurate analysis of its toxic l" Ranunculaceae Aconite species have played an important role in components and the development of efficient de- l" fuzi human history. Aconitum species have been used toxification protocols. Some Asian countries l" monkshood worldwide as poisons as well as remedies. Their started small clinical trials to evaluate the potency l" traditional Chinese medicine l" Ayurvedic medicine potential in targeting several ailments such as and safety of different marketed aconite prepara- pain, rheumatism, and lethargy has been recog- tions. The current review summarizes therapeu- nized by Western, Chinese, and Indian health care tic uses of aconite preparations in China, Taiwan, practitioners. Aconite use in herbal preparations India, and Japan. It also highlights clinical trial re- has declined, especially in Europe and the United sults with special emphasis on their limitations. States, in the first half of the twentieth century Modern drugs and pharmacopoeial preparations due to several reported toxicity cases. The situa- derived from aconite are also discussed. received March 16, 2015 revised May 14, 2015 accepted May 17, 2015 Introduction Rchb. [6]. Several isoquinoline alkaloids and phe- Bibliography ! nethylamine derivatives have also been isolated, DOI http://dx.doi.org/ Aconitum, also known as monkshood, wolfʼs bane, such as higenamine from A.
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