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(12) Patent Application Publication (10) Pub. No.: US 2016/0000843 A1 Lowe Et Al

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(12) Patent Application Publication (10) Pub. No.: US 2016/0000843 A1 Lowe Et Al US 2016.000O843A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/0000843 A1 LOWe et al. (43) Pub. Date: Jan. 7, 2016 (54) HIGH CANNABIDIOL CANNABIS STRAINS Publication Classification (71) Applicant: MJAR Holdings, LLC, Miami, FL (US) (51) Int. Cl. A61E36/85 (2006.01) (72) Inventors: James Lowe, Denver, CO (US); A63L/92 (2006.01) Matthew Curran, Denver (CO); A63L/047 (2006.01) Benjamin Franz, Denver (CO) (52) U.S. Cl. CPC ............. A61K 36/185 (2013.01); A61 K3I/047 (73) Assignee: MUAR Holdings, LLC, Miami, FL (US) (2013.01); A6 IK3I/92 (2013.01) (21) Appl. No.: 14/755,275 (57) ABSTRACT (22) Filed: Jun. 30, 2015 The invention described herein relates to a cannabis cultivar O O that produces high concentrations of cannabidiol. The inven Related U.S. Application Data tion further relates to preparations and products derived from (60) Provisional application No. 62/019,810, filed on Jul. 1, the cannabis cultivar. Also provided are methods of treating 2014, provisional application No. 62/031.538, filed on conditions that are treatable by cannabidiol. by administering Jul. 31, 2014. a preparation or product derived from the cannabis cultivar. US 2016/0000843 A1 Jan. 7, 2016 HIGH CANNABDOL CANNABSSTRANS the glioma tumor, PCT Publication WO/2007/148094 dis closes use of cannabinoids composition for the treatment of CROSS-REFERENCE TO OTHER neuropathic pain; and U.S. Pat. Publication US2010/0286098 APPLICATIONS discloses a method of treating tissue injury in a patient with colitis administering the cannabinoids. 0001. This application claims priority to U.S. Provisional 0009 While a wide range of medical uses has been iden Application Ser. No. 62/019,810, filed Jul. 1, 2014, and tified, the benefits achieved by cannabinoids for a particular 62/031.538, filed Jul. 31, 2014, each of which is incorporated disease or condition are believed to be attributable to a sub herein by reference in its entirety. group of cannabinoids or to individual cannabinoids. That is BACKGROUND OF THE INVENTION to say that different Subgroups or single cannabinoids have beneficial effects on certain conditions, while other sub 0002 1. Field of the Invention groups or individual cannabinoids have beneficial effects on 0003. This invention is directed in part to cannabis culti other conditions. For example, THC is the main psychoactive vars with high concentrations of cannabidiol and/or canna cannabinoid produced by Cannabis and is well-characterized bidiolic acid and low concentrations of A9-tetrahydrocannab for its biological activity and potential therapeutic application inol and/or tetrahydrocannabinolic acid. in a broad spectrum of diseases. CBD, another major cannab 0004 2. State of the Art inoid constituent of Cannabis, acts as an inverse agonist of the 0005 Cannabis has long been considered to have medici CB1 and CB2 cannabinoid receptors. Unlike THC, CBD does nal properties. Many states, such as Colorado, Washington, not produce psychoactive effects in humans. CBD is reported Oregon, California, Alaska, Maine, Hawaii, Nevada, Ver to exert analgesic, antioxidant, anti-inflammatory, and immu mont, Montana, Rhode Island, New Mexico, Michigan, New nomodulatory effects. Jersey, allow the use of medicinal cannabis by persons with 0010 Terpenes, including terpenoids, are another class of debilitating medical conditions as certified by physicians. compounds that are produced by cannabis. Reportedly, as 0006 Cannabinoids, which are compounds derived from many as 200 or more terpenes can be produced by cannabis cannabis, are a group of chemicals from Cannabis species, plants, although the types and ratios ofterpenes produced by including Cannabis sativa, Cannabis ruderalis, and Can a cannabis strain are dependent on genetics and growth con nabis indica plant that are known to activate cannabinoid ditions (e.g., lighting, fertilization, Soil, watering frequency/ receptors (i.e., CB1 and CB2) in cells. There are at least 85 amount, humidity, carbon dioxide concentration, and the different cannabinoids that can be isolated from cannabis. like), as well as age, maturation, and time of day. Terpenes Plant cannabinoids are termed “phytocannabinoids.” Can have been shown to have medicinal properties, and may be nabinoids are also produced endogenously in humans and responsible for at least a portion of the medicinal value of other animals and are termed “endocannabinoids.” “Syn cannabis. thetic cannabinoids' are manmade chemicals with the same/ 0011. Some of the medical benefits attributable to one or similar structures as phytocannabinoids or endocannab more of the terpenes isolated from cannabis include treatment inoids. of sleep disorders, psychosis, anxiety, epilepsy and seizures, pain, microbial infections (fungal, bacterial, etc.), cancer, 0007 Cannabinoids are cyclic molecules exhibiting par inflammation, spasms, gastric reflux, depression, and asthma. ticular properties, such as the ability to easily cross the blood Some terpenes have been shown to: lower the resistance brain barrier, weak toxicity and few side effects. The most across the blood-brain barrier, act on cannabinoid receptors notable cannabinoids produced by cannabis are A9-tetrahy and other neuronal receptors, stimulate the immune system, drocannabinol (i.e., THC) and cannabidiol (i.e., CBD). and/or Suppress appetite. 0008. Some of the medical benefits attributable to one or 0012 To date, however, medicinal marijuana is used as a more of the cannabinoids isolated from cannabis include generic product whereby the patient utilizes the entirety of the treatment of pain, nausea, AIDS-related weight loss and wast different cannabinoids to achieve medicinal results. Efforts ing, multiple Sclerosis, allergies, infection, depression, have been made to maximize the medicinal benefit of can migraine, bipolar disorders, hypertension, post-stroke neuro nabis for a patient having a particular condition, but Such protection, epilepsy, and fibromyalgia, as well as inhibition of efforts are invariably complicated. For example, because tumor growth, angiogenesis and metastasis. Studies have THC is psychoactive, Some patients and regulatory authori shown that cannabinoids may also be useful for treating con ties view cannabis with high CBD (and low THC) as being an ditions such as glaucoma, Parkinson's disease, Huntington's alternative to traditional marijuana that is acceptable, legally, disease, migraines, inflammation, Crohn's disease, dystonia, medically, and/or culturally. Additionally, cannabis rheumatoid arthritis, emesis due to chemotherapy, inflamma tory bowel disease, atherosclerosis, posttraumatic stress dis employed by a patient lacks consistent cannabinoid compo order, cardiac reperfusion injury, prostate carcinoma, and nents and concentrations, and thereby fails to provide the Alzheimer's disease. For example, U.S. Pat. No. 6,630,507 maximum benefit to the patient. discloses cannabinoids for use as antioxidants and neuropro 0013 Cannabis expresses a large number of cannabinoids tectants; U.S. Pat. No. 7,105,685 discloses cannabinoids for which are useful in the treatment of a variety of diseases. the treatment of diseases associated with immune dysfunc However, the usefulness of a cannabis cultivar for a particular tion, particularly HIV disease and neoplastic disorders; U.S. disease is dependent upon the concentration of one or more Pat. No. 7,109,245 discloses cannabinoids useful as vasocon specific cannabinoids, and/or the ratio between amounts of strictors; U.S. Pat. Publication US2011/0257256 discloses cannabinoids, produced by the cultivar. THC-CBD composition for use in treating or preventing Cog nitive Impairment and Dementia; PCT Publication WO/2009/ SUMMARY OF THE INVENTION 147439 discloses use of cannabinoids in the manufacture of a 0014 Cannabis and products or preparations thereof can medicament for use in the treatment of cancer, in particular be used to treat a variety of medical conditions in patients. US 2016/0000843 A1 Jan. 7, 2016 However, the effectiveness of a given cannabis strain or cul drocannabinolic acid concentration of less than about 1% by tivar in the treatment of a certain medical condition or symp weight. In a preferred embodiment, the cannabis cultivar tom is dependent on the type(s) of cannabinoids present in the produces an assayable combined A9-tetrahydrocannabinol cultivar, strain, or preparation, both with respect to the and tetrahydrocannabinolic acid concentration of less than amount of given cannabinoids and the ratios thereof. Cannab about 0.1% by weight. inoid types and concentrations are dependent on a number of 0021. In one embodiment, the cannabis cultivar produces factors, including cultivar or strain type (e.g., genetic back an estimated active cannabidiol concentration is at least about ground), growth conditions, harvest conditions, and methods 18% by weight. In one embodiment, the cannabis cultivar of preparation. produces an estimated active cannabidiol concentration is at 0015 Cannabidiol (CBD) has been implicated in the treat least about 20% by weight. ment of a wide variety of diseases and symptoms, including 0022. In one embodiment, the cannabis cultivar produces cancer, nausea, chronic pain, spasms, seizures/epilepsy, anxi an active A9-tetrahydrocannabinol concentration of less than ety, psoriasis, Crohn's disease, rheumatoid arthritis, diabetes, about 3% by weight. In one embodiment, the cannabis culti schizophrenia, post-traumatic stress disorder (PTSD), alco var produces an active A9-tetrahydrocannabinol
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