Drug Utilisation of Codeine in Children: EMA Analyses of the Health Improvement Network and of the IMS Health German Databases

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11 February 2013 EMA/65632/2013/

Drug utilisation of codeine in children: EMA analyses of The Health Improvement Network and of the IMS Health German databases

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1. PASS information

Title Drug utilisation of codeine in children: EMA analyses of The Health Improvement Network and of the IMS Health German databases

Protocol version identifier 1.0

Date of last version of the protocol 18 January 2013

EU PAS Register No: Study not registered

Active substance Codeine ATC code: R05DA04, N02AA59, N02AA79

Medicinal product(s):

Product reference:

Procedure number:

Study initiator EMA

Research question and objectives On 3 October 2012, the European Medicines Agency started a review of codeine-containing medicines under Article 31 of Directive 2001/83/EC. Recent concerns have arisen over an increased risk of morphine toxicity when codeine is given to children after surgery. In particular, cases have been reported of fatal or life-threatening respiratory depression in children who are ultra-rapid metabolisers and were given codeine after surgical removal of the tonsils. On 31 October 2012 the scope of the review was extended from post-surgery pain relief in children to pain relief in children.

This study seeks to determine the extent to which codeine is prescribed or dispensed to children and the incidence of death occurring within this population.

Analyses are done in the THIN database (UK general practice) and IMS database (German general and specialists practice).

Authors Gianmario Candore & Kristian Svendsen

2. Marketing authorisation holder

Marketing authorisation holder(s) Multiple

Table of contents

1. PASS information ...... 2

2. Marketing authorisation holder ...... 2

3. Responsible parties ...... 5

4. Rationale and background ...... 5

5. Research question and objectives ...... 5

6. Research methods ...... 6 6.1. Study design - THIN ...... 6 6.1.1. Setting ...... 6 6.1.2. Variables ...... 6 6.1.3. Data sources ...... 7 6.1.4. Study size ...... 7 6.1.5. Data management ...... 7 6.1.6. Data analysis ...... 7 6.1.7. Limitations of the research methods ...... 7 6.2. Study design - IMS ...... 7 6.2.1. Setting ...... 7 6.2.1. Variables ...... 8 6.2.2. Data sources ...... 8 6.2.5. Study size ...... 8 6.2.3. Data management ...... 8 6.2.4. Data analysis ...... 8 6.2.5. Limitations of the research methods ...... 8 6.3. Study design – Comparison of prevalence in UK, Germany, Denmark and Sweden ...... 8 6.3.1. Setting ...... 8 6.3.2. Variables ...... 8 6.3.3. Data sources ...... 8 6.3.4. Study size ...... 9 6.3.5. Data management ...... 9 6.3.6. Data analysis ...... 9 6.3.7. Limitations of the research methods ...... 9

7. Plans for disseminating and communicating study results ...... 9

8. Results ...... 10 8.1. THIN ...... 10 8.2 IMS ...... 14 8.3 Comparison of prevalence in UK, Germany, Denmark and Sweden ...... 15 8.4 Discussion and summary ...... 16

9. References ...... 18

ANNEX 1. Codes used in THIN analysis ...... 19

ANNEX 2. Codes used in IMS analysis ...... 28

List of Abbreviations

AMR: Acceptable Mortality Reporting

ATC: Anatomical Therapeutic Chemical, World Health Organisation classification system for drugs.

CYP2D6: Cytochrome P450 2D6, liver enzyme

EMA: European Medicines Agency

EU: European Union

GP: General Practitioner, Family Doctor

PRAC: Pharmacovigilance Risk Assessment Committee

THIN: The Health Improvement Network

3. Responsible parties

Project lead: Gianmario Candore & Kristian Svendsen

Clinical lead: Kevin Blake

Statistical and sign-off: Jim Slattery

4. Rationale and background

On 3 October 2012, the European Medicines Agency (EMA) started a review of codeine-containing medicines at the request of the United Kingdom regulatory authority under Article 31 of Directive 2001/83/EC. Codeine is a widely used analgesic, authorised for use in adults and children and also indicated as a cough suppressant. In the European Union (EU), codeine-containing medicines have been approved via national procedures, and are available either on prescription or over the counter in different Member States. Codeine is marketed as a single-ingredient medicine or in combination with other substances such as acetyl salicylic acid or paracetamol.

Codeine is converted into morphine in the body by the CYP2D6 enzyme. It is well known that some patients who are ‘CYP2D6 ultra-rapid metabolisers’ convert codeine to morphine at a faster than normal rate, resulting in higher than normal levels of morphine in their blood. High levels of morphine can lead to toxic effects such as breathing difficulties. Prevalence of the mutations causing ultra-rapid metabolising varies widely between countries and has been estimated in Europe from 1% in the Nordic countries and 4% in Germany up to 10% of the Portuguese, Italian, Greek and Spanish population (Ingelman-Sundberg, 2005). Recent concerns have arisen over an increased risk of morphine toxicity when codeine is given to children after surgery. In particular, a very small number of cases have been reported of fatal or life-threatening respiratory depression in children who are ultra-rapid metabolisers and were given codeine after surgical removal of the tonsils or adenoids. After discussions, on 31 October 2012 the scope of the review was extended from post-surgery pain relief in children to pain relief in children.

5. Research question and objectives

The PRAC review will evaluate the impact of new and existing information from available sources on the benefit risk balance of codeine-containing medicines when used for pain relief in children.

The present analyses concern the utilisation of codeine in children and the incidence of death occurring within this population.

Codeine has a wide variety of formulations, combinations and indications. Since both pain and cough, codeine’s two primary indications, are symptoms belonging to many different possible indications this limited the possibility to conduct a proper analysis of reasons for use. We decided to focus on a single indication: tonsillectomy/adenoidectomy since it is frequently performed in young children, may require post-operative pain relief and was mentioned by the FDA in their enquiry into the use of codeine in children (FDA, 2012).

Analyses will be performed in the THIN database (UK general practice) and IMS database (German general and specialists practice). Prevalence data from these sources will also be compared with data from Sweden and Denmark which is available on-line.

Objective:

• Estimate of prevalence of codeine exposure in children in the UK, DE, SE and DK;

• Incidence of death in UK children prescribed codeine by different time windows;

• Cause of death analysis in UK children prescribed codeine and dying within a short time frame;

• UK prevalence of prescription of codeine in tonsillectomy and/or adenoidectomy procedures, given these specific procedures were an initial source of concern.

6. Research methods

6.1. Study design - THIN

6.1.1. Setting

The study population is from the THIN source population less than 20 years old with a prescription of codeine during the study period. The choice of 19 years old as a cut-off will allow comparing the results with Danish and Swedish national data.

The period of valid data collection will be defined from the left censoring date up to the right censoring date as follows:

- Left censoring date: the latest of the Acceptable Mortality Reporting (AMR) date of the GP practice, the computerisation date of the GP practice or the date a patient enrolled into a GP practice;

- Right censoring date: the earliest of the date a patient died, the date a patient was transferred out of the GP practice or the last collection date for the GP practice.

The study period is restricted from 1st January 2001 to 31st December 2011.

6.1.2. Variables

Identification of codes for codeine is detailed in Annex 1.

Date of death was taken from the electronic ‘Patient’ file.

Cause of death information was searched for in the ‘Additional Health Data’ and the ‘Medical’ files using both the ‘Read code’ for cause of death (for more information on Read Code please refer to http://www.eastlancspct.nhs.uk/EasySiteWeb/getresource.axd?AssetID=45796&) and any other information entered on the date of death.

Tonsillectomy and/or adenoidectomy procedures were searched for in the ‘Medical’ file using the Read codes.

6.1.3. Data sources

The THIN General Practitioner database version September 2012. Data includes 11,350,933 patients from a total of 559 practices. Of these patients 9,593,278 are classed as acceptable for research and 3,802,018 patients are currently registered with active THIN practices.

6.1.4. Study size

This study is an exploratory analysis of THIN data. No sample size or power calculations were performed.

6.1.5. Data management

All analysis was performed in SAS Enterprise Guide 4.3.

6.1.6. Data analysis

• Prevalence

o number and percentage of children prescribed codeine per year from 2001 to 2011;

o prevalence stratified according to age groups and gender • Death

o incidence of death in children prescribed codeine at different time intervals after the last prescription of codeine;

o cause of death was further analysed when the death occurs within two weeks • Number of tonsillectomy and/or adenoidectomy procedures in children and the percentage with a prescription of codeine in different time intervals;

• Extent of acute use estimated by the percentage of children with only one prescription received during a calendar year or over the study period out of all children prescribed codeine.

6.1.7. Limitations of the research methods

• Data are restricted to a subset of UK general practitioners’ practices;

• The primary data source: THIN is data collected from General Practitioners’ computer software. This poses some challenges in what is recorded and what is not. Data sent from other sources such as hospitals might not always be recorded, and dates will not automatically be correct so some caution is needed;

• Any prescription prescribed by a physician at a hospital would be missing;

• Codeine is available over-the-counter in the United Kingdom and this use is not captured

6.2. Study design - IMS

6.2.1. Setting

The study population was identified from the IMS source population less than 20 years old with a prescription of codeine during the study period. The choice of 19 years old as a cut-off allowed comparison of the results with Danish and Swedish national data.

The study period is restricted from 1st January 2001 to 31st December 2011.

6.2.1. Variables

Identification of codes for codeine is detailed in Annex 2.

6.2.2. Data sources

The IMS Health German database version September 2012. The database contains information from general practitioners and specialists working outside hospital. 25,178,025 patients are in the data, while about 5 million patients are active in any calendar year.

6.2.5. Study size

This study is an exploratory analysis of IMS data. No sample size or power calculations is performed.

6.2.3. Data management

Initial analysis was performed in IMS Disease Analyser.

6.2.4. Data analysis

This analysis is mainly exploratory and only investigated:

• Prevalence

o number and percentage of children prescribed codeine in 2011;

o prevalence stratified according to age groups and gender • Extent of acute use estimated by number of prescriptions received during a calendar year or over the study period

6.2.5. Limitations of the research methods

• Data are restricted to a subset of German general practitioners’ and specialists practices;

• The primary data source (IMS) is data collected from physicians’ computer software. This poses some challenges in what is recorded and what is not. Data sent from other sources such as hospitals might not always be recorded, and dates will not automatically be correct so some caution is needed.

• Any prescription prescribed by a physician at a hospital would be missing.

6.3. Study design – Comparison of prevalence in UK, Germany, Denmark and Sweden

6.3.1. Setting

The study population is derived from the UK and German analyses conducted and the entire population of Denmark and Sweden.

The study period is restricted to 2011.

6.3.2. Variables

Identification of codes for codeine is detailed in Annex 1 for UK, Annex 2 for Germany and the following ATC codes for Denmark and Sweden: R05DA04, N02AA59, N02AA79.

6.3.3. Data sources

The Danish and Swedish data comes from the respective national prescription databases:

• Sweden: Socialstyrelsen, http://192.137.163.49/sdb/lak/val.aspx

• Denmark: Statens Serum Institut, http://www.medstat.dk/en

6.3.4. Study size

This study shows descriptive data from different sources.

6.3.5. Data management

Data for Denmark and Sweden are available online aggregated by age group and gender.

6.3.6. Data analysis

• Prevalence

o percentage of children exposed to codeine in 2011;

o stratified according to age groups 6.3.7. Limitations of the research methods

Differences of data sources (prescribed in the UK and Germany; dispensed in Denmark and Sweden).

7. Plans for disseminating and communicating study results

The study results will be forwarded to the PRAC Rapporteur and PRAC within the timeframe for the PRAC review.

8. Results

8.1. THIN

• Prevalence

A total of 91,112 children age 0 – 19 years old were prescribed codeine out of 2,515,938 children in THIN during the study period.

Figure 1 and 2 present an overview of the prevalence stratified by gender and age group over time. While the overall prevalence does not change dramatically over the period analysed and it’s higher in female and in the older age groups, in the younger age groups there is a decline, particularly in the 0 – 4 years old group where there is a decline from 0.30% in 2005 to 0.06% in 2011.

Figure 1: Gender stratified prevalence by year

1.60%

1.40%

1.20%

1.00%

0.80%

0.60%

0.40%

0.20%

0.00% 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 Male 0.83% 0.80% 0.80% 0.76% 0.84% 0.87% 0.88% 0.82% 0.81% 0.75% 0.69% Female 1.31% 1.27% 1.30% 1.28% 1.40% 1.42% 1.51% 1.50% 1.47% 1.42% 1.41% Total 1.06% 1.02% 1.04% 1.01% 1.11% 1.13% 1.18% 1.15% 1.13% 1.08% 1.04% Male Female Total

Figure 2: Age group stratified prevalence by year

3.50%

3.00%

2.50%

2.00%

1.50%

1.00%

0.50%

0.00% 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 0 - 4 0.34% 0.29% 0.32% 0.30% 0.30% 0.29% 0.28% 0.22% 0.15% 0.13% 0.06% 5 - 9 0.34% 0.31% 0.29% 0.27% 0.32% 0.31% 0.31% 0.25% 0.21% 0.20% 0.14% 10 - 14 0.99% 0.88% 0.86% 0.78% 0.84% 0.85% 0.89% 0.85% 0.81% 0.73% 0.75% 15 - 19 2.72% 2.72% 2.76% 2.71% 2.96% 3.03% 3.15% 3.12% 3.18% 3.08% 3.04%

0 - 4 5 - 9 10 - 14 15 - 19

Figure 3 shows prevalence stratified by both gender and age for the year 2011 where both the gender difference and the strong increase in the codeine prescribing for children aged 10 and older can be noticed.

Figure 3: Gender and age group stratified prevalence - 2011

• Death

Table 1 shows the number and percentage of children prescribed codeine who died during the study period and the corresponding background rate of death among THIN children during the same period stratified by gender.

Table 1: Gender stratified death for children prescribed codeine and children THIN population Codeine prescribed THIN Gender Death % Death % Death Male 161 0.45% 0.21% Female 128 0.23% 0.12% Total 289 0.32% 0.16%

Table 2 focuses on the incidence of death in children prescribed codeine at different intervals after the last prescription of codeine: a total of 10 children died within 14 days.

Table 2: Death at different intervals for children prescribed codeine (2001 – 2011) Time Interval Deaths Less than 4 days 3 4 to 7 days 2 8 to 14 days 5 15 to 30 days 12 31 to 90 days 30 More than 90 days 206 Death date missing 31

In the 31 patients where death date was missing, medical events and text comments were investigated to check that death did not appear within a short time period from codeine prescription. None of these patients seem to appear in this category.

In the 10 patients dead within 14 days, additional information on medical events and cause of deaths were retrieved. In addition, de-identification of text comments was requested from THIN to gain more information; a summary of the patient information is reported in table 3. None of these patients have a reported cause of death related to codeine toxicity.

Table 3: Cause of death in children who died within 14 days (2001 – 2011) Time to Previous Year of Patient Gender Age Reason of death death codeine use death Less than 4 Unknown, palliative 1 Female 2 No 2011 days patient Less than 4 2 Male 2 Unknown No 2003 days Less than 4 3 Female 7 Cancer No 2006 days 4 Male 5 4 to 7 days Cancer Yes 2006 Unknown, sickly patient with 5 Female 7 4 to 7 days Yes 2011 frequent hospital admissions 6 Female 9 8 to 14 days Metabolic acidosis Yes 2004 Cancer 7 Male 9 8 to 14 days Yes 2003 complications Intracranial 8 Female 12 8 to 14 days No 2004 haemorrhage 9 Male 13 8 to 14 days Cancer No 2001 10 Male 14 8 to 14 days Cancer Yes 2005 No tonsillectomy or adenoidectomy was conducted in these patients within plus/minus 365 days of the final prescription before death

• Extent of acute use

More than 80% of children prescribed codeine received only one codeine prescription during a calendar year and more than 70% received only one codeine prescription during the whole study period.

• Tonsillectomy and/or adenoidectomy

Table 4 shows the number of tonsillectomy and/or adenoidectomy procedures in children and the percentage with a prescription of codeine in different time intervals in relation to the surgical procedure: codeine was prescribed in 9% of tonsillectomy procedures and 0.5% of adenoidectomies (within +/- 7 days).

The peak of prescription was in the period 4 to 7 days post-operatively.

Table 4: Codeine prescribed in tonsillectomy and/or adenoidectomy procedures (2001 – 2011) Surgical procedure Tonsillectomy Adenoidectomy Both Tot number of events 21,171 7,317 8,254 Total with codeine 14,376 830 1,472 prescription Same day 1.9% 0.1% 0.4% +/- 3 days 2.3% 0.2% 0.7% -3 days 0.3% 0.0% 0.1% +3 days 1.9% 0.2% 0.6% +/- 4 to 7 days 4.7% 0.3% 1.5% -4 to -7 days 0.3% 0.0% 0.1% +4 to +7 days 4.4% 0.3% 1.4% +/- 8 to 30 days 2.0% 0.3% 0.5% -8 to -30 days 0.7% 0.1% 0.2% +8 to +30 days 1.3% 0.2% 0.3% Unrelated (> 30 days) 57.0% 10.6% 14.8%

8.2 IMS

• Prevalence

In IMS Germany a total of 59,625 children received at least one prescription of codeine during the study period. In 2011, there were 12,259 codeine-prescribed children, this was 0.34% of the total population of children in 2011 (3,547,640).

Figure 4 shows prevalence stratified by both gender and age for the year 2011: prevalence is stable across both categories. In order to calculate the prevalence all patients in the database aged 0-19 were used as the denominator, not only the active ones (as it was done for THIN). The older the patient the greater the chance that he or she is no longer contributing to the database; however the extent of this issue is at present unknown.

Figure 4: Gender and age group stratified prevalence - 2011

The data was also stratified according to age groups for comparison with other countries (see section 8.3).

• Acute use

In the study period, a total of 99,529 codeine prescriptions to 59,625 children give an average number of prescriptions per children of 1.67. This indicates that use is predominately acute.

8.3 Comparison of prevalence in UK, Germany, Denmark and Sweden

• Prevalence

Figure 5 shows the prevalence of children prescribed codeine stratified by age group in the UK, Germany, Denmark and Sweden for the year 2011.

Figure 5: Age group stratified prevalence country comparison - 2011

3.5%

3.0%

2.5%

2.0%

1.5%

1.0%

0.5%

0.0% 0 - 4 5 - 9 10 - 14 15 - 19 UK Denmark Sweden Germany

From figure 5 it can be noticed that Germany has a stable prevalence across all age groups and shows the highest prevalence in the younger groups (0 to 9 years old) and the lowest in the older group. All other countries show an increasing prevalence with age, with the United Kingdom having the most marked increase.

8.4 Discussion and summary

1) Prevalence:

The main findings with regard to prevalence are:

• Total number of children in THIN (UK) prescribed codeine in 2001 - 2011 is 91,112; in IMS (Germany) in the same period is 59,625;

• In THIN prevalence of codeine use is slightly above 1% in the group of patients age 0 to 19; it has not changed overall during the period analysed, however, there are trends for lower prescribing in the youngest age groups;

• If compared with Denmark and Sweden, prevalence in UK is substantially higher in all age groups in spite of the different data sources;

• Germany is the only country with a seemingly stable prevalence across all age groups and shows the highest prevalence in the age groups 0 to 9 years old and the lowest in the older group.

The data sources used to present prevalence have differences in how the data is recorded as well as how the prevalence is calculated. In THIN the data is exclusively from GPs prescriptions giving an underestimate of the real prevalence because codeine is available over the counter (OTC) at pharmacies in the UK. Also prescriptions prescribed outside the GP are not captured. On the other hand prescription data always overestimate use since prescriptions are not always dispensed and dispensed drugs are not always taken.

The IMS German data contains data from both GP and private practices with specialists including paediatricians. However the German data has no standardized way of determining if the patient is still active and eligible for drug use. We selected to use all patients in the database. This will give an underestimation of the prevalence in general. Because of these issues the main focus of the analysis has been on using the UK THIN data.

The Swedish and Danish data comes from dispensed data from all pharmacies and as such it captures a larger proportion of the total use.

Finally, it should be considered that the populations analysed are mainly from Northern Europe; this population has the lowest proportion of CYP2D6 ultra-rapid metabolisers around 1-4% (Ingelman- Sundberg, 2005).

2) Prevalence by gender and age in THIN and IMS:

The main findings with regard to gender and age stratified prevalence are:

• In THIN, females have a substantially higher prevalence than males (double in 2011), while in IMS prevalence is similar between genders;

• In THIN, the gender difference appears for children aged 10 and older; in IMS the similarity between genders is constant across all ages considered.

The results by gender should be reliable and representative of the population as a whole. However the age prevalence should be interpreted more carefully for IMS since the use of the complete database (not only the active patients as in THIN) might skewer the results. The older children have had a longer possible follow-up in the database and are more likely to be lost to follow up (by moving or

16 simply changing GP), compared to the younger children with only a short time period in the IMS database.

3) Death:

The main findings of the analysis of cause of death are:

• In THIN, during the study period, 10 patients were identified to have died within two weeks from the last codeine prescription;

• None of these patients have a reported cause of death related to codeine toxicity;

• No tonsillectomy and/or adenoidectomy were conducted in these patients within plus/minus 365 days of the final prescription before death.

Death is recorded in THIN since GP is usually aware of patient’s death and he/she is required to record the information. Cause of death can also be populated in the database; however this is often not the case. While the date of death is considered reliable, the cause of death had to be found indirectly for a majority of the 10 patients dead within 14 days after a codeine prescription. This has been done searching their medical records and in the free text fields the GPs can use.

4) Tonsillectomy and/or adenoidectomy

• In THIN, codeine was prescribed in relation to 9% of tonsillectomy procedures in children (+/- 7 days);

• In THIN, codeine prescribing with adenoidectomy was lower (0.5% within +/- 7 days)

A relatively low co-prescribing of codeine in children receiving tonsillectomy and/or adenoidectomy has been found in THIN. However codeine prescribed at the hospital during the procedure or codeine given at the hospital is not captured by THIN.

5) Acute vs. repeat use:

• Both in THIN and IMS, prescription seems predominantly for acute use.

Gianmario Candore/Kristian Svendsen

Study Lead

Date: 11 February 2013

9. References

Food and Drug Administration. FDA Drug Safety Communication: Codeine use in certain children after tonsillectomy and/or adenoidectomy may lead to rare, but life-threatening adverse events or death. 15 August 2011. http://www.fda.gov/Drugs/DrugSafety/ucm313631.htm (accessed 07/02/13).

Fredheim OMS, Log T, Olsen W, et al. Prescriptions of opioids to children and adolescents; a study from a national prescription database in Norway. Paediatr Anaesth 2010;20:537-44.

Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J. 2005;5(1):6-13.

ANNEX 1. Codes used in THIN analysis

BNF1 BNF2 BNF3 generic name ATC multilexeid 04.07.01.00 00.00.00.00 00.00.00.00 ACETYLSALICYLIC ACID / CODEINE PHOSPHATE MG TAB N02B A51 99781992 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN & CODEINE 500 MG TAB N02B A51 96585992 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN & CODEINE 75 MG TAB 96950992 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN & CODEINE paed 75 MG TAB 96111992 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN / CAFFEINE CIT./ CODEINE PHOS./ 200 MG TAB 93271992 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN + CODEINE disp tab 400mg + 8mg N02B A51 96217997 04.07.01.01 00.00.00.00 00.00.00.00 ASPIRIN + CODEINE PHOSPHATE & CAFFEINE disp tab 94356998 04.07.01.01 00.00.00.00 00.00.00.00 ASPIRIN + CODEINE PHOSPHATE & CAFFEINE tabs 93320998 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN + CODEINE PHOSPHATE & CAFFEINE tabs N02B A51 94356997 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN + CODEINE sol tab 500mg + 8mg N02B A51 96217996 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN + CODEINE tabs 400mg + 8mg N02B A51 96217998 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN/CODEINE PHOSPHATE/PARACETAMOL 250 MG TAB 99737992 04.07.01.00 00.00.00.00 00.00.00.00 ASPIRIN/CODEINE PHOSPHATE/PARACETAMOL 300 MG TAB 99899992 03.09.02.00 00.00.00.00 00.00.00.00 BROMPHENIRAMINE /CODEINE PHOSPHATE / 2 MG ELI 96993992 03.09.02.00 00.00.00.00 00.00.00.00 BROMPHENIRAMINE MALEATE & CODEINE elixir 95089998 04.07.04.01 00.00.00.00 00.00.00.00 BUCLIZINE HYD/CODEINE PHOS/DOCUSATE SOD/ 6.25 MG TAB 96122992 04.07.04.01 00.00.00.00 00.00.00.00 BUCLIZINE HYD/CODEINE PHOS/PARACET / COD 6.25 MG TAB N02C 96997992 04.07.01.00 00.00.00.00 00.00.00.00 CAFFEINE /CODEINE PHOS /PARACETAMOL TAB N02B E51 95871992 04.07.01.00 00.00.00.00 00.00.00.00 CAFFEINE /CODEINE PHOS./DOXYLAMINE SUCCI 30 MG TAB 96128992 04.07.01.00 00.00.00.00 00.00.00.00 CAFFEINE CITRATE/CODEINE PHOSPHATE/PARAC 15 MG TAB 97014992 04.07.01.00 00.00.00.00 00.00.00.00 CAFFEINE HYDRATE /CODEINE PHOSPHATE /PAR 10 MG TAB 96598992 04.07.01.00 00.00.00.00 00.00.00.00 CAFFEINE/CODEINE PHOS./DIPHENHYDRAMINE H 50 MG TAB N02B E51 97016992 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 91123998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 91195998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 91940998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 93233990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 93259996 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 93761990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 93820990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 93941990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 94827998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 97876988 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 30mg + 500mg N02B E51 98737997 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 8mg+500mg N02B E51 85545998 04.07.02.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 8mg+500mg 92855998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 8mg+500mg N02B E51 92869990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 8mg+500mg N02B E51 92909990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 8mg+500mg N02B E51 96753996 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 8mg+500mg N02B E51 97582997 04.07.02.00 00.00.00.00 00.00.00.00 CO-CODAMOL caps 8mg+500mg R05D A04 99358998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL EFF 30MG/500MG TAB N02B E51 93342992 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 86582998

04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 87547998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 91123997 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 92417990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 92533990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 92780990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 93259998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 93819990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 94284990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 94827997 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 95206990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 95609990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 96987990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 30mg + 500mg N02B E51 97934990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 92377990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 94157990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 94470990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 94489990 04.07.02.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg R05D A04 95450998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 96304990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 96753997 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 97071990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 97125990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 97207989 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 97582998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 97876990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 97984990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL eff tab 8mg+500mg N02B E51 99674990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL sf eff pwdr 30mg + 500mg N02B E51 89015998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL sf eff pwdr 30mg + 500mg N02B E51 89016998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL sf eff pwdr 60mg + 1000mg N02B E51 89016997 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL sf eff pwdr 60mg + 1000mg N02B E51 90729998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 12.8mg + 500mg N02B E51 84015998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 12.8mg + 500mg N02B E51 87997998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 12.8mg + 500mg N02B E51 92891998 04.07.02.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 15mg + 500mg 81934998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 15mg + 500mg N02B E51 91235998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 15mg + 500mg N02B E51 91806998 04.07.02.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 15mg + 500mg 92079990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 15mg + 500mg N02B E01 95449998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 91123996 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 91195997 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 93259997 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 93708990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 93762990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 93817990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 94762990

04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 95003990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 95267990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 97876989 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 98737998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 99674988 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 30mg + 500mg N02B E51 99677989 04.07.04.01 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02C 89184998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 92461990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 93021990 04.07.01.02 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg 93328998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 94677990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 95345990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 95411990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 95451998 04.07.02.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg R05D A04 95452998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 95671990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 96122990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 96184990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 96753998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 96824990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 96983990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 97207990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 97244990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 97676990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 98184990 04.07.04.01 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02C 98213998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 98470998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 98577990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 99674989 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 99675990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 99676990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 99677990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAMOL tabs 8mg+500mg N02B E51 99678990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAPRIN disp tab 8mg+400mg N02B A51 93099990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAPRIN disp tab 8mg+400mg N02B A51 97919998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAPRIN disp tab 8mg+400mg N02B A51 98093997 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAPRIN disp tab 8mg+400mg N02B A51 98576990 04.07.01.01 00.00.00.00 00.00.00.00 CO-CODAPRIN disp tab 8mg+400mg 99280989 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAPRIN sol tab 8mg+500mg N02B A51 94612998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAPRIN sol tab 8mg+500mg N02B A51 99818998 04.07.01.01 00.00.00.00 00.00.00.00 CO-CODAPRIN tabs 8mg+400mg 97922990 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAPRIN tabs 8mg+400mg N02B A51 98093998 04.07.01.00 00.00.00.00 00.00.00.00 CO-CODAPRIN tabs 8mg+400mg N02B A51 98575990 04.07.01.01 00.00.00.00 00.00.00.00 CO-CODAPRIN tabs 8mg+400mg 98593990 04.07.01.01 00.00.00.00 00.00.00.00 CO-CODAPRIN tabs 8mg+400mg 98594990 04.07.01.01 00.00.00.00 00.00.00.00 CO-CODAPRIN tabs 8mg+400mg 99279990

04.07.01.01 00.00.00.00 00.00.00.00 CO-CODAPRIN tabs 8mg+400mg 99280990 04.07.01.01 00.00.00.00 00.00.00.00 CO-CODAPRIN tabs 8mg+400mg 99809990 04.07.01.00 00.00.00.00 00.00.00.00 CODAGESIC TAB 93481992 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE & PARACETAMOL 8 MG TAB N02B E51 93308992 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE & PARACETAMOL TAB N02B E51 93849992 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE 8MG & PARACETAMOL 500MG SUP 97188992 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE CO SOLUBLE TAB 97181992 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE CO TAB 95895992 03.09.02.00 00.00.00.00 00.00.00.00 CODEINE PHOS /DIPHENHYDRAMINE HYD. /MENT 5.7 MG ELI 96166992 03.09.02.00 00.00.00.00 00.00.00.00 CODEINE PHOS/EPHEDRINE HYD/PROMETHAZINE LIN R05X 93307992 03.09.02.00 00.00.00.00 00.00.00.00 CODEINE PHOS/GUAIPHENESIN/PSEUDOEPHEDRIN 3 MG ELI 96167992 03.09.02.00 00.00.00.00 00.00.00.00 CODEINE PHOS/GUAIPHENESIN/PSEUDOEPHEDRIN 7.5 MG ELI 93310992 10.01.01.00 00.00.00.00 00.00.00.00 CODEINE PHOS/IBUPROFEN SR (20MG/300MG) TAB M01A E 95852992 01.04.02.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE / MAGNESIUM CHLORIDE MG MIX 96165992 04.07.01.01 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + ASPIRIN & CAFFEINE disp tab 96617997 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + ASPIRIN & CAFFEINE tabs N02B A51 93863998 04.07.01.01 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + ASPIRIN & CAFFEINE tabs 96617998 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + ASPIRIN disp tab 8mg+400mg N02B A51 92141998 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + ASPIRIN sol tab 8mg + 500mg N02B A51 89898998 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + ASPIRIN tabs 8mg+400mg N02B A51 89787998 03.09.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + CREOSOTE syrp 1.9mg + 16.75mg 93313998 03.09.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + CREOSOTE syrp 1.9mg + 16.75mg 93314998 01.04.02.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + DICYCLOVERINE & SALTS liq R05D A04 94103998 01.04.02.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + DICYCLOVERINE & SALTS liq 94105998 04.07.01.02 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + DIPHENHYDRAMINE, PARACETAMOL, 94275998 PHENYLEPHRINE, CAFFEINE & VITAMIN C tabs

03.09.02.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + GUAIACOL expectorant R05X 90330998 03.09.02.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + GUAIACOL expectorant 90333998 01.04.02.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + KAOLIN susp 10mg + 3g/10ml A07D A52 94104998 01.04.02.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + KAOLIN susp 10mg + 3g/10ml R05D A04 99518998 03.09.02.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + MENTHOL elixir 15mg/5ml R05X 94267998 03.09.02.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + MENTHOL elixir 15mg/5ml 94269998 03.09.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + OTHER INGREDIENTS pastille 88375998 03.09.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + OTHER INGREDIENTS pastille 88376998 04.07.04.01 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL & BUCLIZINE tabs N02C 93966998 8mg+500mg+6.25mg 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL caps 30mg + 500mg N02B E51 94767998 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL caps 8mg+500mg N02B E51 90643998 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL eff tab 30mg + 500mg N02B E51 88880998 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL eff tab 8mg + 500mg N02B E51 96616997 04.07.01.02 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL elixir paed 94767997 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL sf eff pwdr 30mg + 500mg N02B E51 98553997 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL sf eff pwdr 60mg + 1000mg N02B E51 98553998 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL tabs 12.8mg + 500mg N02B E51 84014998 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL tabs 15mg + 500mg N02B E51 89068998 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL tabs 30mg + 500mg N02B E51 96616996 04.07.01.00 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL tabs 8mg + 500mg N02B E51 96616998

04.07.01.02 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL, DIPHENHYDRAMINE & 93817998 CAFFEINE tabs 400mg+10mg+5mg+50mg

04.07.01.02 00.00.00.00 00.00.00.00 CODEINE PHOSPHATE + PARACETAMOL, DOXYLAMINE & CAFFEINE 93816998 tabs 10mg + 450mg + 5mg + 30mg

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04.07.01.00 00.00.00.00 00.00.00.00 PARACETAMOL + CODEINE PHOSPHATE, DOXYLAMINE & CAFFEINE N02B E51 99085998 tabs 450mg+10mg+5mg+30mg

04.07.01.00 00.00.00.00 00.00.00.00 PARACETAMOL + CODEINE tabs 500mg + 12.8mg N02B E51 87993998 04.07.01.02 00.00.00.00 00.00.00.00 PARACETAMOL + CODEINE, HYOSCINE & CAFFEINE tabs 93324998 04.07.01.00 00.00.00.00 00.00.00.00 PARACETAMOL + CODEINE, HYOSCINE & CAFFEINE tabs N02B E51 93327998 04.07.01.02 00.00.00.00 00.00.00.00 PARACETAMOL + DIPHENHYDRAMINE, CODEINE, PHENYLEPHRINE, 94281998 CAFFEINE & VITAMIN C tabs

04.07.01.00 00.00.00.00 00.00.00.00 PARACETAMOL,CAFFEINE,CODEINE & NICOTINAM TAB 97865992 04.07.01.00 00.00.00.00 00.00.00.00 PARACETAMOL/CODEINE PHOSPHATE 500 MG TAB N02B E51 93597992 03.04.01.00 00.00.00.00 00.00.00.00 PHENYLEPHRINE + DIPHENHYDRAMINE, PARACETAMOL, CODEINE, 84441998 CAFFEINE & VITAMIN C tabs

04.07.01.02 00.00.00.00 00.00.00.00 PHENYLEPHRINE + DIPHENHYDRAMINE, PARACETAMOL, CODEINE, 94265998 CAFFEINE & VITAMIN C tabs

03.09.02.00 00.00.00.00 00.00.00.00 PHENYLEPHRINE + DIPHENHYDRAMINE, PARACETAMOL, CODEINE, R01B A 94279998 CAFFEINE & VITAMIN C tabs

03.09.02.00 00.00.00.00 00.00.00.00 PSEUDOEPHEDRINE + BROMPHENIRAMINE & CODEINE PHOSPHATE R05X 88403998 elixir 03.09.01.00 00.00.00.00 00.00.00.00 PSEUDOEPHEDRINE + BROMPHENIRAMINE & CODEINE PHOSPHATE 94313998 elixir 03.09.02.00 00.00.00.00 00.00.00.00 PSEUDOEPHEDRINE + BROMPHENIRAMINE & CODEINE PHOSPHATE R05X 99753998 elixir 03.09.01.00 00.00.00.00 00.00.00.00 PSEUDOEPHEDRINE + BROMPHENIRAMINE & CODEINE PHOSPHATE 94313997 paed syrp 03.09.02.00 00.00.00.00 00.00.00.00 PSEUDOEPHEDRINE + BROMPHENIRAMINE & CODEINE PHOSPHATE R05X 98679998 paed syrp 04.07.02.00 00.00.00.00 00.00.00.00 SOLPADEINE FORTE TAB R05D A04 95599992 04.07.02.00 00.00.00.00 00.00.00.00 TERCOLIX 15 MG SYR R05D A04 98159992 04.07.01.00 00.00.00.00 00.00.00.00 Co-codamol 15mg/500mg capsules 81102998 04.07.01.00 00.00.00.00 00.00.00.00 Co-codamol 15mg/500mg capsules 81101998 04.07.01.00 04.07.02.00 04.07.01.00 Co-codamol 15mg/500mg effervescent tablets sugar free N02B E51 81219998 04.07.01.00 04.07.02.00 04.07.01.00 Co-codamol 15mg/500mg tablets N02B E51 86502979 04.07.01.00 04.07.01.00 04.07.02.00 Co-codamol 30mg/500mg tablets N02B E51 95687979 04.07.01.00 04.07.01.00 04.07.02.00 Co-codamol 30mg/500mg tablets N02B E51 58621979 04.07.01.00 04.07.01.00 04.07.02.00 Co-codaprin 8mg/400mg tablets N02B A51 70038979 03.09.01.00 04.07.02.00 00.00.00.00 Codeine 3mg/5ml linctus paediatric R05D A04 96919979 10.01.01.00 04.07.02.00 10.01.01.00 IBUPRO+CODEINE 200/12.8mg tabs M01A E51 93048992 04.07.01.00 04.07.02.00 04.07.01.00 PARACET+COD 500mg/15mg eff tab N02B E51 81218998 04.07.01.00 00.00.00.00 00.00.00.00 PARADEINE TAB A06A B04 97869992

ANNEX 2. Codes used in IMS analysis

Product-No Product-Name WHO-ATC5_Code Substance 21939 TUSSORETARD N ??????? DIPHENHYDRAMINE + CODEINE + NOSCAPINE 341 ANTI-OPT (LVS) ??????? SALICYLAMIDE + PARACETAMOL + CODEINE 46407 CODIPRONT MONO R05DA04 CODEINE 74647 GELONIDA N02AA69 PARACETAMOL + CODEINE 1267 CODIPRONT ??????? PHENYLTOLOXAMINE + CODEINE 576 AZUR COMPOSITUM N02AA59 PARACETAMOL + CAFFEINE + CODEINE 576 AZUR COMPOSITUM N02AA59 PARACETAMOL + CAFFEINE + CODEINE 576 AZUR COMPOSITUM N02AA59 PARACETAMOL + CAFFEINE + CODEINE 576 AZUR COMPOSITUM N02AA69 PARACETAMOL + CAFFEINE + CODEINE 690 BENADRYL M.CODEIN ??????? DIPHENHYDRAMINE + CODEINE 691 BENADRYL M.COD.ALT ??????? DIPHENHYDRAMINE + CODEINE 691 BENADRYL M.COD.ALT ??????? DIPHENHYDRAMINE + CODEINE 23023 PARACETAM.COM.STAD N02AA69 PARACETAMOL + CODEINE 796 BISOLVON GRIBLETT. ??????? ACETYLSALICYLIC ACID + BROMHEXINE + CODEINE 797 BISOLVON GRI.MTK>> ??????? ACETYLSALICYLIC ACID + BROMHEXINE + CODEINE 23023 PARACETAM.COM.STAD N02AA69 PARACETAMOL + CODEINE 867 BRONCHICUM C.COD. ??????? CODEINE + ASPIDOSPERMA QUEBRACHO + SAPONARIA OFFICINALIS 26765 COMBAREN N02AA65 DICLOFENAC + CODEINE 24591 CODEINUM PHOSP.B-C R05DA04 CODEINE 87781 PARACETAM.COMP.AL N02AA69 PARACETAMOL + CODEINE 74647 GELONIDA N02AA69 PARACETAMOL + CODEINE 1197 CIBALEN N ??????? PROPYPHENAZONE + CODEINE + DROFENINE 1197 CIBALEN N ??????? PROPYPHENAZONE + CODEINE + DROFENINE 1197 CIBALEN N ??????? PROPYPHENAZONE + CODEINE + DROFENINE 1197 CIBALEN N ??????? PROPYPHENAZONE + CODEINE + DROFENINE 1197 CIBALEN N ??????? PROPYPHENAZONE + CODEINE + DROFENINE 1197 CIBALEN N ??????? PROPYPHENAZONE + CODEINE + DROFENINE 1257 CODEINUM PHOSP.ALT R05DA04 CODEINE 1257 CODEINUM PHOSP.ALT R05DA04 CODEINE 1257 CODEINUM PHOSP.ALT R05DA04 CODEINE 1257 CODEINUM PHOSP.ALT R05DA04 CODEINE 1259 CODICAPS B ??????? BROMHEXINE + CHLORPHENAMINE + CODEINE 1259 CODICAPS B ??????? BROMHEXINE + CHLORPHENAMINE + CODEINE 1260 CODICAPS A ??????? CHLORPHENAMINE + CODEINE 1260 CODICAPS A ??????? CHLORPHENAMINE + CODEINE 1260 CODICAPS A ??????? CHLORPHENAMINE + CODEINE 1260 CODICAPS A ??????? CHLORPHENAMINE + CODEINE 1262 CODICOMPREN ALT R05DA04 CODEINE 1262 CODICOMPREN ALT R05DA04 CODEINE 1263 CODIDOXAL ??????? CODEINE + DOXYCYCLINE 1264 CODIPERTUSSIN(ATM) R05DA04 CODEINE 1264 CODIPERTUSSIN(ATM) R05DA04 CODEINE 1264 CODIPERTUSSIN(ATM) R05DA04 CODEINE

1265 CODIPERTUSSIN R05DA04 CODEINE 1266 CODIPRONT C.EXPECT ??????? GUAIFENESIN + PHENYLTOLOXAMINE + CODEINE 1266 CODIPRONT C.EXPECT ??????? GUAIFENESIN + PHENYLTOLOXAMINE + CODEINE 1266 CODIPRONT C.EXPECT ??????? GUAIFENESIN + PHENYLTOLOXAMINE + CODEINE 1267 CODIPRONT ??????? PHENYLTOLOXAMINE + CODEINE 1267 CODIPRONT ??????? PHENYLTOLOXAMINE + CODEINE 1267 CODIPRONT ??????? PHENYLTOLOXAMINE + CODEINE 1267 CODIPRONT ??????? PHENYLTOLOXAMINE + CODEINE 1267 CODIPRONT ??????? PHENYLTOLOXAMINE + CODEINE 1269 CODYL N ??????? DOXYLAMINE + CODEINE 1363 CONTRANEURAL N ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 1363 CONTRANEURAL N ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 1363 CONTRANEURAL N ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 79897 CODEINTROPFEN CT R05DA04 CODEINE 79897 CODEINTROPFEN CT R05DA04 CODEINE 2601 GELONIDA NA ??????? SALICYLIC ACID + PARACETAMOL + CODEINE 1846 DOLO VISANO ??????? ACETYLSALICYLIC ACID + MEPROBAMATE + CODEINE 1846 DOLO VISANO ??????? ACETYLSALICYLIC ACID + MEPROBAMATE + CODEINE 1870 DOLVIRAN ALT N02AA59 CAFFEINE + ACETYLSALICYLIC ACID + CODEINE 1870 DOLVIRAN ALT N02AA59 CAFFEINE + ACETYLSALICYLIC ACID + CODEINE 1870 DOLVIRAN ALT N02AA59 CAFFEINE + ACETYLSALICYLIC ACID + CODEINE 87870 MAKATUSSIN CODEIN R05DA04 CODEINE 23480 CODICAPS R05DA04 CODEINE 1265 CODIPERTUSSIN R05DA04 CODEINE 2601 GELONIDA NA ??????? SALICYLIC ACID + PARACETAMOL + CODEINE 2601 GELONIDA NA ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 2601 GELONIDA NA ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 2601 GELONIDA NA ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 2601 GELONIDA NA ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 3191 IPALAT C.CODEIN ??????? EPHEDRINE + CODEINE + CEPHAELIS IPECACUANHA 3670 LONARID N N02AA59 PARACETAMOL + CAFFEINE + CODEINE 3670 LONARID N N02AA59 PARACETAMOL + CAFFEINE + CODEINE 3670 LONARID N N02AA59 PARACETAMOL + CAFFEINE + CODEINE 3670 LONARID N N02AA59 PARACETAMOL + CAFFEINE + CODEINE 3670 LONARID N N02AA59 PARACETAMOL + CAFFEINE + CODEINE 3670 LONARID N N02AA59 PARACETAMOL + CAFFEINE + CODEINE 3670 LONARID N N02AA59 PARACETAMOL + CAFFEINE + CODEINE 3840 MELROSUM M.CODEIN ??????? CODEINE + HONEY 3897 MEXE N02AA69 PARACETAMOL + CODEINE 3897 MEXE N02AA69 PARACETAMOL + CODEINE 3909 MIGRAEFLUX ??????? PARACETAMOL + CODEINE + DIMENHYDRINATE 3909 MIGRAEFLUX ??????? PARACETAMOL + CODEINE + DIMENHYDRINATE 3909 MIGRAEFLUX ??????? PARACETAMOL + CODEINE + DIMENHYDRINATE 3909 MIGRAEFLUX ??????? PARACETAMOL + CODEINE + DIMENHYDRINATE 3918 MIGRAENE-KRANIT N ??????? PARACETAMOL + PROPYPHENAZONE + CODEINE 3925 MIGRALAVE ??????? PARACETAMOL + CODEINE + BUCLIZINE

3925 MIGRALAVE ??????? PARACETAMOL + CODEINE + BUCLIZINE 3925 MIGRALAVE ??????? PARACETAMOL + CODEINE + BUCLIZINE 4096 MUSKEL TRANC.C.COD ??????? PARACETAMOL + CHLORMEZANONE + CODEINE 4096 MUSKEL TRANC.C.COD ??????? PARACETAMOL + CHLORMEZANONE + CODEINE 4097 MUSKEL TRANC.COMP ??????? PARACETAMOL + CHLORMEZANONE + CODEINE 4097 MUSKEL TRANC.COMP ??????? PARACETAMOL + CHLORMEZANONE + CODEINE 4179 NEDOLON A N02AA59 ACETYLSALICYLIC ACID + CODEINE 4180 NEDOLON P N02AA69 PARACETAMOL + CODEINE 4180 NEDOLON P N02AA69 PARACETAMOL + CODEINE 4515 OPTIPECT KODEIN R05DA04 CODEINE 4517 OPTIPYRIN ??????? ETHENZAMIDE + CODEINE + TROSPIUM 4517 OPTIPYRIN ??????? ETHENZAMIDE + CODEINE + TROSPIUM 26765 COMBAREN N02AA65 DICLOFENAC + CODEINE 4713 PECTINFANT N ??????? CODEINE + DIPHENYLPYRALINE 4960 PRAECIMED N ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 4960 PRAECIMED N ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 4961 PRAECINEURAL N02AA59 ACETYLSALICYLIC ACID + CODEINE 4961 PRAECINEURAL N02AA59 GLYCINE + ACETYLSALICYLIC ACID + CODEINE 77103 CODEINSAFT CT R05DA04 CODEINE 46407 CODIPRONT MONO R05DA04 CODEINE 39970 VOLTAREN PLUS N02AA65 DICLOFENAC + CODEINE 5672 SPASMO CIB.COMP S ??????? PROPYPHENAZONE + CODEINE + DROFENINE 5672 SPASMO CIB.COMP S ??????? PROPYPHENAZONE + CODEINE + DROFENINE 5672 SPASMO CIB.COMP S ??????? PROPYPHENAZONE + CODEINE + DROFENINE 5672 SPASMO CIB.COMP S ??????? PROPYPHENAZONE + CODEINE + DROFENINE 5672 SPASMO CIB.COMP S ??????? PROPYPHENAZONE + CODEINE + DROFENINE 5672 SPASMO CIB.COMP S ??????? PROPYPHENAZONE + CODEINE + DROFENINE 23480 CODICAPS R05DA04 CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 25451 LONGTUSSIN (RCP) R05FA02 GUAIFENESIN + CODEINE 6173 TREUPEL ??????? SALICYLAMIDE + PARACETAMOL + CODEINE 6173 TREUPEL ??????? SALICYLAMIDE + PARACETAMOL + CODEINE 6173 TREUPEL ??????? SALICYLAMIDE + PARACETAMOL + CODEINE 6173 TREUPEL ??????? SALICYLAMIDE + PARACETAMOL + CODEINE 6173 TREUPEL ??????? SALICYLAMIDE + PARACETAMOL + CODEINE 6173 TREUPEL ??????? SALICYLAMIDE + PARACETAMOL + CODEINE 6173 TREUPEL ??????? SALICYLAMIDE + PARACETAMOL + CODEINE 23480 CODICAPS R05DA04 CODEINE

6195 TRICODEIN ALT R05DA04 CODEINE 6195 TRICODEIN ALT R05DA04 CODEINE 6253 TUSSORETARD ??????? CODEINE + NOSCAPINE 6548 VIBRATUSSAL ??????? CODEINE + DOXYCYCLINE 690 BENADRYL M.CODEIN ??????? DIPHENHYDRAMINE + CODEINE 7154 CODIPRONT EUP>> ??????? PHENYLTOLOXAMINE + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 46407 CODIPRONT MONO R05DA04 CODEINE 233305 BRONCH.MON.COD(NAT R05DA04 CODEINE 233305 BRONCH.MON.COD(NAT R05DA04 CODEINE 2601 GELONIDA NA ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 24591 CODEINUM PHOSP.B-C R05DA04 CODEINE 51032 CODICOMPREN (GSK) R05DA04 CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 39970 VOLTAREN PLUS N02AA65 DICLOFENAC + CODEINE 35503 CODIPRONT SVP>> ??????? PHENYLTOLOXAMINE + CODEINE 42476 CODEINUM PHOSP(GSK R05DA04 CODEINE 8832 CODICEPT R05DA04 CODEINE 7154 CODIPRONT EUP>> ??????? PHENYLTOLOXAMINE + CODEINE 8833 CODYL (ABT) ??????? CODEINE + PAPAVERINE + NOSCAPINE 8919 AZUR COMPOSIT.SC A N02AA69 PARACETAMOL + CODEINE 2601 GELONIDA NA ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 46407 CODIPRONT MONO R05DA04 CODEINE 4179 NEDOLON A N02AA59 ACETYLSALICYLIC ACID + CODEINE 4960 PRAECIMED N ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 79897 CODEINTROPFEN CT R05DA04 CODEINE 9934 TITRETTA PROPYPH. ??????? PROPYPHENAZONE + CODEINE 15914 NEO-CODION R05DA04 CODEINE 42476 CODEINUM PHOSP(GSK R05DA04 CODEINE 84179 CODIPRONT AC9>> ??????? PHENYLTOLOXAMINE + CODEINE 74947 PARACETACOD-RATIOP N02AA69 PARACETAMOL + CODEINE 10370 EXPECTAL S ??????? SULFOGAIACOL + CODEINE + THYMUS VULGARE 56309 SILERIN CC R05DA04 CODEINE 4960 PRAECIMED N ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 56309 SILERIN CC R05DA04 CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 11284 BENADRYL N M.COD. ??????? DIPHENHYDRAMINE + CODEINE 690 BENADRYL M.CODEIN ??????? DIPHENHYDRAMINE + CODEINE 294738 TITRETTA PARACET. N02AA69 PARACETAMOL + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 107847 CIBALGIN COMP. ??????? PROPYPHENAZONE + CODEINE 87781 PARACETAM.COMP.AL N02AA69 PARACETAMOL + CODEINE 1870 DOLVIRAN ALT N02AA59 ACETYLSALICYLIC ACID + CODEINE 48064 PARACETAM.COMP SOH N02AA69 PARACETAMOL + CODEINE 9934 TITRETTA PROPYPH. ??????? PROPYPHENAZONE + CODEINE

51032 CODICOMPREN (GSK) R05DA04 CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 7154 CODIPRONT EUP>> ??????? PHENYLTOLOXAMINE + CODEINE 13540 ERGO-LONARID N ??????? PARACETAMOL + CODEINE + DIHYDROERGOTAMINE 9324 MIGRAEFLUX N N02BE51 PARACETAMOL + CODEINE 9324 MIGRAEFLUX N N02BE51 PARACETAMOL + CODEINE 576 AZUR COMPOSITUM N02AA69 PARACETAMOL + CAFFEINE + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 3897 MEXE N02AA69 PARACETAMOL + CODEINE 23023 PARACETAM.COM.STAD N02AA69 PARACETAMOL + CODEINE 8919 AZUR COMPOSIT.SC A N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 26765 COMBAREN N02AA65 DICLOFENAC + CODEINE 23480 CODICAPS R05DA04 CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 17789 FORTALIDON S ??????? PROPYPHENAZONE + CODEINE 35501 CODIPRONT WTH>> ??????? PHENYLTOLOXAMINE + CODEINE 19367 LONARID N02AA69 PARACETAMOL + CODEINE 15914 NEO-CODION ??????? CODEINE + ETHYLMORPHINE 35496 CODIPRONT GRK>> ??????? PHENYLTOLOXAMINE + CODEINE 3918 MIGRAENE-KRANIT N ??????? PARACETAMOL + PROPYPHENAZONE + CODEINE 1265 CODIPERTUSSIN R05DA04 CODEINE 64161 OPTIPYRIN PFL N02AA69 PARACETAMOL + CODEINE 19367 LONARID N02AA69 PARACETAMOL + CODEINE 66573 PILFOR P N02AA69 PARACETAMOL + CODEINE 78866 PARACET COMP CT N02AA69 PARACETAMOL + CODEINE 107814 DOLVIRAN (HEX) N02AA66 CAFFEINE + ACETYLSALICYLIC ACID + CODEINE 78866 PARACET COMP CT N02AA69 PARACETAMOL + CODEINE 107814 DOLVIRAN (HEX) N02AA59 CAFFEINE + ACETYLSALICYLIC ACID + CODEINE 13540 ERGO-LONARID N ??????? PARACETAMOL + CODEINE + DIHYDROERGOTAMINE 10370 EXPECTAL S ??????? SULFOGAIACOL + CODEINE + THYMUS VULGARE 35472 CODEINTROPFEN RIB R05DA04 CODEINE 107814 DOLVIRAN (HEX) N02AA66 CAFFEINE + ACETYLSALICYLIC ACID + CODEINE 4515 OPTIPECT KODEIN R05DA04 CODEINE 107847 CIBALGIN COMP. ??????? PROPYPHENAZONE + CODEINE 35495 CODIPRONT E-M>> ??????? PHENYLTOLOXAMINE + CODEINE 394932 TUSSORET (AES) R05DA04 CODEINE 64422 CODIPRONT KHP>> ??????? PHENYLTOLOXAMINE + CODEINE 21607 DICTON HUSTEN- R05DA04 CODEINE 21607 DICTON HUSTEN- R05DA04 CODEINE 35495 CODIPRONT E-M>> ??????? PHENYLTOLOXAMINE + CODEINE 13540 ERGO-LONARID N ??????? PARACETAMOL + CODEINE + DIHYDROERGOTAMINE 17789 FORTALIDON S ??????? PROPYPHENAZONE + CODEINE 9934 TITRETTA PROPYPH. ??????? PROPYPHENAZONE + CODEINE

19367 LONARID N02AA69 PARACETAMOL + CODEINE 3918 MIGRAENE-KRANIT N ??????? PARACETAMOL + PROPYPHENAZONE + CODEINE 21782 MIRFUSOT +CODEIN N ??????? CODEINE + THYMUS VULGARE 84633 AZUR COMPOSITUM SC N02AA69 PARACETAMOL + CODEINE 64422 CODIPRONT KHP>> ??????? PHENYLTOLOXAMINE + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 21939 TUSSORETARD N ??????? DIPHENHYDRAMINE + CODEINE + NOSCAPINE 21939 TUSSORETARD N ??????? DIPHENHYDRAMINE + CODEINE + NOSCAPINE 13540 ERGO-LONARID N ??????? PARACETAMOL + CODEINE + DIHYDROERGOTAMINE 17789 FORTALIDON S ??????? PROPYPHENAZONE + CODEINE 2601 GELONIDA NA ??????? SALICYLIC ACID + PARACETAMOL + CODEINE 19367 LONARID N02AA69 PARACETAMOL + CODEINE 46407 CODIPRONT MONO R05DA04 CODEINE 107847 CIBALGIN COMP. ??????? PROPYPHENAZONE + CODEINE 19367 LONARID N02AA69 PARACETAMOL + CODEINE 71813 CODIPRONT OTI>> ??????? PHENYLTOLOXAMINE + CODEINE 6173 TREUPEL N02AA69 PARACETAMOL + CODEINE 22931 BRONCHOFOR.+KODEIN R05DA04 CODEINE 88763 SPASM.CI.C.S EUP>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 19367 LONARID N02AA69 PARACETAMOL + CODEINE 23076 TUSSIPECT M.COD.N ??????? EPHEDRINE + CODEINE + THYMUS VULGARE 15914 NEO-CODION R05DA04 CODEINE 867 BRONCHICUM C.COD. ??????? MENTHOL + CODEINE 35494 CODIPRONT BRA>> ??????? PHENYLTOLOXAMINE + CODEINE 9934 TITRETTA PROPYPH. ??????? CAFFEINE + PROPYPHENAZONE + CODEINE 23076 TUSSIPECT M.COD.N ??????? EPHEDRINE + CODEINE + THYMUS VULGARE 74647 GELONIDA N02AA69 PARACETAMOL + CODEINE 11284 BENADRYL N M.COD. ??????? DIPHENHYDRAMINE + CODEINE 21607 DICTON HUSTEN- R05DA04 CODEINE 35496 CODIPRONT GRK>> ??????? PHENYLTOLOXAMINE + CODEINE 3840 MELROSUM M.CODEIN ??????? CODEINE + HONEY 6173 TREUPEL N02AA69 PARACETAMOL + CODEINE 19367 LONARID N02AA69 PARACETAMOL + CODEINE 6248 TUSSIPECT M.CODEIN R05DA04 CODEINE 19367 LONARID N02AA69 PARACETAMOL + CODEINE 24237 PECTINFANT S R05DA04 CODEINE 15914 NEO-CODION ??????? CODEINE + ETHYLMORPHINE 6173 TREUPEL N02AA69 PARACETAMOL + CODEINE 25178 TUSSORET ALT R05DA04 CODEINE 25357 CODIPRONT RETARD ??????? PHENYLTOLOXAMINE + CODEINE 25357 CODIPRONT RETARD ??????? PHENYLTOLOXAMINE + CODEINE 90725 SPASM.CI.C.S E-M>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 25451 LONGTUSSIN (RCP) ??????? GUAIFENESIN + CODEINE + CHLORPHENOXAMINE 25620 TUSSAMAG CODEIN R05DA04 CODEINE 35499 CODIPRONT MTK>> ??????? PHENYLTOLOXAMINE + CODEINE 35503 CODIPRONT SVP>> ??????? PHENYLTOLOXAMINE + CODEINE

84633 AZUR COMPOSITUM SC N02AA69 PARACETAMOL + CODEINE 15914 NEO-CODION ??????? CODEINE + ETHYLMORPHINE 91904 SPASM.CI.C.S MTK>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 3758 MAKATUSSIN (MAK) ??????? CODEINE + DROSERA ROTUNDIFOLIA 8919 AZUR COMPOSIT.SC A N02AA59 PARACETAMOL + CAFFEINE + CODEINE 107847 CIBALGIN COMP. ??????? PROPYPHENAZONE + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 25620 TUSSAMAG CODEIN R05DA04 CODEINE 25620 TUSSAMAG CODEIN R05DA04 CODEINE 8919 AZUR COMPOSIT.SC A N02AA59 PARACETAMOL + CAFFEINE + CODEINE 1870 DOLVIRAN ALT N02AA59 ACETYLSALICYLIC ACID + CODEINE 42476 CODEINUM PHOSP(GSK R05DA04 CODEINE 294738 TITRETTA PARACET. N02AA69 PARACETAMOL + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 1870 DOLVIRAN ALT N02AA59 ACETYLSALICYLIC ACID + CODEINE 15914 NEO-CODION ??????? CODEINE + ETHYLMORPHINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 15914 NEO-CODION R05DA04 CODEINE 2601 GELONIDA NA ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 74947 PARACETACOD-RATIOP N02AA69 PARACETAMOL + CODEINE 91904 SPASM.CI.C.S MTK>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 64161 OPTIPYRIN PFL N02AA69 PARACETAMOL + CODEINE 35472 CODEINTROPFEN RIB R05DA04 CODEINE 394932 TUSSORET (AES) R05DA04 CODEINE 73482 BRONCH.MON.COD.ALT R05DA04 CODEINE 35501 CODIPRONT WTH>> ??????? PHENYLTOLOXAMINE + CODEINE 71813 CODIPRONT OTI>> ??????? PHENYLTOLOXAMINE + CODEINE 73482 BRONCH.MON.COD.ALT R05DA04 CODEINE 90819 CODIPRONT ME.>> ??????? PHENYLTOLOXAMINE + CODEINE 9934 TITRETTA PROPYPH. ??????? PROPYPHENAZONE + CODEINE 66573 PILFOR P N02AA69 PARACETAMOL + CODEINE 84179 CODIPRONT AC9>> ??????? PHENYLTOLOXAMINE + CODEINE 84179 CODIPRONT AC9>> ??????? PHENYLTOLOXAMINE + CODEINE 64422 CODIPRONT KHP>> ??????? PHENYLTOLOXAMINE + CODEINE 88763 SPASM.CI.C.S EUP>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 25178 TUSSORET ALT R05DA04 CODEINE 35477 CODIFORTON R05DA04 CODEINE 1265 CODIPERTUSSIN R05DA04 CODEINE 85911 SPASMO CIB.S WTH>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 576 AZUR COMPOSITUM N02AA59 PARACETAMOL + CAFFEINE + CODEINE 9934 TITRETTA PROPYPH. ??????? PROPYPHENAZONE + CODEINE 5672 SPASMO CIB.COMP S ??????? PROPYPHENAZONE + CODEINE + DROFENINE 5672 SPASMO CIB.COMP S ??????? PROPYPHENAZONE + CODEINE + DROFENINE 88386 CONTRAN.PARAC/COD. N02AA69 PARACETAMOL + CODEINE 71813 CODIPRONT OTI>> ??????? PHENYLTOLOXAMINE + CODEINE 75902 CODIPRONT A+S>> ??????? PHENYLTOLOXAMINE + CODEINE

1260 CODICAPS A ??????? CHLORPHENAMINE + CODEINE 60400 TRICODEIN (NV-) R05DA04 CODEINE 91664 SPASM.CI.C.S KHP>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 35496 CODIPRONT GRK>> ??????? PHENYLTOLOXAMINE + CODEINE 89339 CODIPRONT BT5>> ??????? PHENYLTOLOXAMINE + CODEINE 75902 CODIPRONT A+S>> ??????? PHENYLTOLOXAMINE + CODEINE 75902 CODIPRONT A+S>> ??????? PHENYLTOLOXAMINE + CODEINE 35494 CODIPRONT BRA>> ??????? PHENYLTOLOXAMINE + CODEINE 89339 CODIPRONT BT5>> ??????? PHENYLTOLOXAMINE + CODEINE 91664 SPASM.CI.C.S KHP>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 35494 CODIPRONT BRA>> ??????? PHENYLTOLOXAMINE + CODEINE 76433 CODIPRONT GWL>> ??????? PHENYLTOLOXAMINE + CODEINE 90819 CODIPRONT ME.>> ??????? PHENYLTOLOXAMINE + CODEINE 87752 DOLVIRAN (BAY)ALT N02AA59 CAFFEINE + ACETYLSALICYLIC ACID + CODEINE 3840 MELROSUM M.CODEIN ??????? CODEINE + HONEY 60400 TRICODEIN (NV-) R05DA04 CODEINE 9934 TITRETTA PROPYPH. ??????? PROPYPHENAZONE + CODEINE 39970 VOLTAREN PLUS N02AA65 DICLOFENAC + CODEINE 107270 CODIPRONT GPP>> ??????? PHENYLTOLOXAMINE + CODEINE 35499 CODIPRONT MTK>> ??????? PHENYLTOLOXAMINE + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 25178 TUSSORET ALT R05DA04 CODEINE 35496 CODIPRONT GRK>> ??????? PHENYLTOLOXAMINE + CODEINE 35495 CODIPRONT E-M>> ??????? PHENYLTOLOXAMINE + CODEINE 63444 CODI OPT R05DA04 CODEINE 42476 CODEINUM PHOSP(GSK R05DA04 CODEINE 15914 NEO-CODION R05DA04 CODEINE 76433 CODIPRONT GWL>> ??????? PHENYLTOLOXAMINE + CODEINE 84179 CODIPRONT AC9>> ??????? PHENYLTOLOXAMINE + CODEINE 39521 GELONIDA NA MPA>> ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 26765 COMBAREN N02AA65 DICLOFENAC + CODEINE 46407 CODIPRONT MONO R05DA04 CODEINE 35501 CODIPRONT WTH>> ??????? PHENYLTOLOXAMINE + CODEINE 5672 SPASMO CIB.COMP S ??????? PROPYPHENAZONE + CODEINE + DROFENINE 48064 PARACETAM.COMP SOH N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 35494 CODIPRONT BRA>> ??????? PHENYLTOLOXAMINE + CODEINE 85059 SPASMO CIB.S MPA>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 2601 GELONIDA NA ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 35499 CODIPRONT MTK>> ??????? PHENYLTOLOXAMINE + CODEINE 51683 PARACETAM.+COD.PSZ N02AA69 PARACETAMOL + CODEINE 27838 TITRETTA M.BELLAD. ??????? PROPYPHENAZONE + ATROPINE + CODEINE 60549 TRYASOL M.CODEIN ??????? CODEINE + AMMONIUM 27838 TITRETTA M.BELLAD. ??????? PROPYPHENAZONE + ATROPINE + CODEINE 9934 TITRETTA PROPYPH. ??????? CAFFEINE + PROPYPHENAZONE + CODEINE

1863 DOLOMO ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 796 BISOLVON GRIBLETT. ??????? ACETYLSALICYLIC ACID + BROMHEXINE + CODEINE 25178 TUSSORET ALT R05DA04 CODEINE 9934 TITRETTA PROPYPH. ??????? CAFFEINE + PROPYPHENAZONE + CODEINE 1257 CODEINUM PHOSP.ALT R05DA04 CODEINE 35502 CODIPRONT REA>> ??????? PHENYLTOLOXAMINE + CODEINE 67256 CONTRANEURAL FORTE N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 30735 ANTINEUR.C.COD.WIN ??????? ACETYLSALICYLIC ACID + PHENACETIN + CODEINE 67256 CONTRANEURAL FORTE N02AA69 PARACETAMOL + CODEINE 27838 TITRETTA M.BELLAD. ??????? PROPYPHENAZONE + ATROPINE + CODEINE 9934 TITRETTA PROPYPH. ??????? CAFFEINE + PROPYPHENAZONE + CODEINE 35502 CODIPRONT REA>> ??????? PHENYLTOLOXAMINE + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 51683 PARACETAM.+COD.PSZ N02AA69 PARACETAMOL + CODEINE 25620 TUSSAMAG CODEIN R05DA04 CODEINE 3897 MEXE N02AA69 PARACETAMOL + CODEINE 1267 CODIPRONT ??????? PHENYLTOLOXAMINE + CODEINE 75314 CODIPRONT AL6>> ??????? PHENYLTOLOXAMINE + CODEINE 75314 CODIPRONT AL6>> ??????? PHENYLTOLOXAMINE + CODEINE 75314 CODIPRONT AL6>> ??????? PHENYLTOLOXAMINE + CODEINE 75314 CODIPRONT AL6>> ??????? PHENYLTOLOXAMINE + CODEINE 107270 CODIPRONT GPP>> ??????? PHENYLTOLOXAMINE + CODEINE 76433 CODIPRONT GWL>> ??????? PHENYLTOLOXAMINE + CODEINE 35483 CODIPR.C.EXP.BRA>> ??????? GUAIFENESIN + PHENYLTOLOXAMINE + CODEINE 35501 CODIPRONT WTH>> ??????? PHENYLTOLOXAMINE + CODEINE 76614 CODIPRONT ARW>> ??????? PHENYLTOLOXAMINE + CODEINE 690 BENADRYL M.CODEIN ??????? DIPHENHYDRAMINE + CODEINE 35493 CODIPRONT EUM>> ??????? PHENYLTOLOXAMINE + CODEINE 7154 CODIPRONT EUP>> ??????? PHENYLTOLOXAMINE + CODEINE 76614 CODIPRONT ARW>> ??????? PHENYLTOLOXAMINE + CODEINE 76614 CODIPRONT ARW>> ??????? PHENYLTOLOXAMINE + CODEINE 35483 CODIPR.C.EXP.BRA>> ??????? GUAIFENESIN + PHENYLTOLOXAMINE + CODEINE 3897 MEXE N02AA69 PARACETAMOL + CODEINE 51683 PARACETAM.+COD.PSZ N02AA69 PARACETAMOL + CODEINE 78899 SPASMO CIB.S E-M>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 25620 TUSSAMAG CODEIN R05DA04 CODEINE 79677 SPASMO CIB.S EUP>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 3897 MEXE N02AA69 PARACETAMOL + CODEINE 80196 CODIPRONT AEP>> ??????? PHENYLTOLOXAMINE + CODEINE 80196 CODIPRONT AEP>> ??????? PHENYLTOLOXAMINE + CODEINE 35495 CODIPRONT E-M>> ??????? PHENYLTOLOXAMINE + CODEINE 80196 CODIPRONT AEP>> ??????? PHENYLTOLOXAMINE + CODEINE 80196 CODIPRONT AEP>> ??????? PHENYLTOLOXAMINE + CODEINE 81511 SPASMO CIB.S KHP>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 89069 CODIPRONT MVT>> ??????? PHENYLTOLOXAMINE + CODEINE

82453 SPASMO CIB.S MTK>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 107270 CODIPRONT GPP>> ??????? PHENYLTOLOXAMINE + CODEINE 83589 CODIPRONT PW9>> ??????? PHENYLTOLOXAMINE + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 89069 CODIPRONT MVT>> ??????? PHENYLTOLOXAMINE + CODEINE 35481 CODIPR.C.EXP.ACA>> ??????? GUAIFENESIN + PHENYLTOLOXAMINE + CODEINE 87752 DOLVIRAN (BAY)ALT N02AA59 CAFFEINE + ACETYLSALICYLIC ACID + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 89069 CODIPRONT MVT>> ??????? PHENYLTOLOXAMINE + CODEINE 74647 GELONIDA N02AA69 PARACETAMOL + CODEINE 90725 SPASM.CI.C.S E-M>> ??????? PROPYPHENAZONE + CODEINE + DROFENINE 90819 CODIPRONT ME.>> ??????? PHENYLTOLOXAMINE + CODEINE 91272 ANTITUS.BUERG.TABL R05DA04 CODEINE 35492 CODIPRONT ACA>> ??????? PHENYLTOLOXAMINE + CODEINE 178913 PARACETAMOL+COD.EH N02AA69 PARACETAMOL + CODEINE 89339 CODIPRONT BT5>> ??????? PHENYLTOLOXAMINE + CODEINE 39970 VOLTAREN PLUS N02AA65 DICLOFENAC + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 87752 DOLVIRAN (BAY)ALT N02AA59 CAFFEINE + ACETYLSALICYLIC ACID + CODEINE 39521 GELONIDA NA MPA>> ??????? PARACETAMOL + ACETYLSALICYLIC ACID + CODEINE 294738 TITRETTA PARACET. N02AA69 PARACETAMOL + CODEINE 19367 LONARID N02AA69 PARACETAMOL + CODEINE 35503 CODIPRONT SVP>> ??????? PHENYLTOLOXAMINE + CODEINE 576 AZUR COMPOSITUM N02AA59 PARACETAMOL + CAFFEINE + CODEINE 576 AZUR COMPOSITUM N02AA59 PARACETAMOL + CAFFEINE + CODEINE 54522 CODEINPHOSPHAT WIN R05DA04 CODEINE 91272 ANTITUS.BUERG.TABL R05DA04 CODEINE 89339 CODIPRONT BT5>> ??????? PHENYLTOLOXAMINE + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 1267 CODIPRONT ??????? PHENYLTOLOXAMINE + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 294738 TITRETTA PARACET. N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 28146 TRYASOL CODEIN ALT R05DA04 CODEINE 516118 SPASMO-CIB.CO.S EH ??????? PROPYPHENAZONE + CODEINE + DROFENINE 25451 LONGTUSSIN (RCP) R05FA02 GUAIFENESIN + CODEINE 51683 PARACETAM.+COD.PSZ N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 54522 CODEINPHOSPHAT WIN R05DA04 CODEINE 131299 TRYASOL CODEIN(P-W R05DA04 CODEINE 131299 TRYASOL CODEIN(P-W R05DA04 CODEINE 131299 TRYASOL CODEIN(P-W R05DA04 CODEINE 35493 CODIPRONT EUM>> ??????? PHENYLTOLOXAMINE + CODEINE

74647 GELONIDA N02AA69 PARACETAMOL + CODEINE 87781 PARACETAM.COMP.AL N02AA69 PARACETAMOL + CODEINE 84633 AZUR COMPOSITUM SC N02AA69 PARACETAMOL + CODEINE 131299 TRYASOL CODEIN(P-W R05DA04 CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 706353 CODEINTROPFEN HEX. R05DA04 CODEINE 5902 TALVOSILEN N02AA69 PARACETAMOL + CODEINE 706353 CODEINTROPFEN HEX. R05DA04 CODEINE 233305 BRONCH.MON.COD(NAT R05DA04 CODEINE 769227 PARACETAM/COD.BENE N02AA69 PARACETAMOL + CODEINE