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Overview of Planned Or Ongoing Studies of Drugs for the Treatment of COVID-19

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Overview of Planned Or Ongoing Studies of Drugs for the Treatment of COVID-19 Version of 16.06.2020 Overview of planned or ongoing studies of drugs for the treatment of COVID-19 Table of contents Antiviral drugs ............................................................................................................................................................. 4 Remdesivir ......................................................................................................................................................... 4 Lopinavir + Ritonavir (Kaletra) ........................................................................................................................... 7 Favipiravir (Avigan) .......................................................................................................................................... 14 Darunavir + cobicistat or ritonavir ................................................................................................................... 18 Umifenovir (Arbidol) ........................................................................................................................................ 19 Other antiviral drugs ........................................................................................................................................ 20 Antineoplastic and immunomodulating agents ....................................................................................................... 24 Convalescent Plasma ............................................................................................................................................ 24 Immunoglobulins .................................................................................................................................................. 46 Monoclonal antibodies ......................................................................................................................................... 47 Tocilizumab (RoActemra) alone or in combination with other drugs .............................................................. 47 Sarilumab (Kevzara) ......................................................................................................................................... 54 Siltuximab (Sylvant) ......................................................................................................................................... 57 Bevacizumab (Avastin) ..................................................................................................................................... 58 Other monoclonal antibodies .......................................................................................................................... 58 Interferons ............................................................................................................................................................ 67 Protein kinase inhibitors ...................................................................................................................................... 71 Ruxolitinib (Jakavi) ........................................................................................................................................... 71 Baricitinib (Olumiant) ....................................................................................................................................... 75 Other protein kinase inhibitors ........................................................................................................................ 76 Other immunomodulating drugs.......................................................................................................................... 78 Anti-inflammatory drugs .......................................................................................................................................... 93 Leflunomide ..................................................................................................................................................... 93 Colchicine ......................................................................................................................................................... 94 Naproxen ......................................................................................................................................................... 97 Ibuprofen ......................................................................................................................................................... 97 Piclidenoson (CF101) ........................................................................................................................................ 98 Glucocorticoids ......................................................................................................................................................... 98 Stem cell therapy ....................................................................................................................................................103 Cardiovascular drugs ..............................................................................................................................................118 Angiotensin receptor blocker or ACE inhibitor...................................................................................................118 Other ..................................................................................................................................................................122 Spironolactone ...............................................................................................................................................122 Amiodarone and Verapamil ...........................................................................................................................122 Prazosin ..........................................................................................................................................................122 Ifenprodil........................................................................................................................................................123 Atorvastatin ...................................................................................................................................................124 Blood and blood forming organs ............................................................................................................................124 Alteplase ........................................................................................................................................................124 Aspirin ............................................................................................................................................................124 Defibrotide .....................................................................................................................................................125 Tranexamic acid .............................................................................................................................................125 Tinzaparin.......................................................................................................................................................125 1 Version of 16.06.2020 Antitrombin ....................................................................................................................................................126 Dipyridamidole ...............................................................................................................................................126 Dociparstat sodium ........................................................................................................................................127 Enoxaparin .....................................................................................................................................................127 Heparin ..........................................................................................................................................................131 Nafamostat ....................................................................................................................................................132 Ilomedin .........................................................................................................................................................132 Plasminogen Activator ...................................................................................................................................133 Prolongin ........................................................................................................................................................133 Ulinastatin ......................................................................................................................................................133 ACE-2 ......................................................................................................................................................................133 Angiotensin 1-7 .......................................................................................................................................................134 Chloroquine or hydroxychloroquine .......................................................................................................................135 Other drugs studied for the treatment or prevention of COVID-19 .......................................................................173 Alimentary tract and metabolism ......................................................................................................................173
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