Computational Studies of Drug Repurposing Targeting P-Glycoprotein Mediated Multidrug-Resistance Phenotypes in Agents of Neglect
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Bulletin Leading the Fight Against Heartworm Disease
BULLETIN LEADING THE FIGHT AGAINST HEARTWORM DISEASE SEPTEMBER HEARTWORM 2017 Q&A VOLUME 44 No. 3 Heartworm History: In What Year Was Heartworm First INSIDE THIS ISSUE Treated? Page 4 From the President Page 8 Research Update Abstracts from the Literature Page 14 Heartworm Hotline: Role of Heat Treatment in Diagnostics Page 19 NEW! Best Practices: Minimizing Heartworm Transmission in Relocated Dogs uestions from members, prac- published in the 1998 AHS Symposium 1 titioners, technicians, and the Proceedings. Dr. Roncalli wrote, “The Page 21 Qgeneral public are often submit- first trial to assess the efficacy of a Welcome Our New AHS ted to the American Heartworm Society microfilaricide (natrium antimonyl tar- Student Liaisons (AHS) via our website. Two of our AHS trate) was conducted some 70 years Board members, Dr. John W.McCall and ago (1927) in Japan by S. Itagaki and R. Page 25 Dr. Tom Nelson, provided the resources Makino.2 Fuadin (stibophen), a trivalent In the News: Surgeons to answer this question: In What Year antimony compound, was tested, intra- Remove a Heartworm from Was Heartworm First Treated? venously, as a microfilaricide by Popescu the Femoral Artery of a Cat The first efforts to treat canine heart- in 1933 in Romania and by W.H. Wright worm disease date back to the 1920s. Dr. and P.C. Underwood in 1934 in the USA. Page 26 Nelson referenced a review article by Dr. In 1949, I.C. Mark evaluated its use Quarterly Update Raffaele Roncalli, “Tracing the History of intraperitoneally.” What’s New From AHS? Heartworms: A 400 Year Perspective,” Continues on page 7 American Heartworm Society / PO Box 8266, Wilmington, DE 19803-8266 Become an American Heartworm Society www.heartwormsociety.org / [email protected] fan on Facebook! Follow us on Twitter! OUR GENEROUS SPONSORS PLATINUM LEVEL PO Box 8266 Wilmington, DE 19803-8266 [email protected] www.heartwormsociety.org Mission Statement The mission of the American Heartworm Society is to lead the vet- erinary profession and the public in the understanding of heartworm disease. -
Veterinary Guide to Resistance & Parasites
Veterinary Guide to Resistance & Parasites How to make the Get Rotation Right deworming strategy part of your equine health wellness protocol. ||||||||||||||||||||||||||||||||||||||||| GET ROTATION RIGHT Resistant parasites – veterinary involvement is needed now. Deworming has come a long way in the past 50 years – from products that were nearly toxic and required complicated tubing to the easy-to-administer dewormers we know now. As more horse owners recognize the value of regular deworming, past troublemakers such as large strongyles have become much less of a threat. Still, deworming is nothing to take lightly. As internal parasites become more resistant, your expertise is needed Horseowners unknowingly more than ever to make sure deworming programs remain efficient contribute to resistance. and effective. Only with veterinary involvement will we control parasite • Rotating brand names, not populations, combat resistance and get rotation right. chemical classes – general confusion about when and RESISTANCE IS REAL: MULTIPLE DRUGS, MULTIPLE PARASITES. how to use different classes • No new drug class since avermectins in 1981. of dewormers. • Benzimidazole resistance in cyathostomes.1-3 • Lack of knowledge about • Pyrantel resistance in cyathostomes and ascarids.4-8,11 resistance issues. • Ivermectin and moxidectin resistance among ascarids.8,9,11 • Deworming many horses more • Early warning signs of macrocyclic-lactone-resistant cyathostomes.10 frequently than necessary. • Health-related issues caused by parasites: • Misunderstanding about the ~ Ascarids (roundworms) unique properties of larvicidal Verminous pneumonia: cough, nasal discharge, low-grade fever treatments and how to maximize Unthriftiness – rough hair coat their efficacy. Intestinal obstruction/colic • Underdosing their horses. Intestinal perforation leading to peracute death Decreased performance and reduced weight gain ~ Cyathostomes (small strongyles) Most common in young and old horses, but can afflict any horse. -
Table of Contents Introduction
TABLE OF CONTENTS INTRODUCTION............................................................................................................. 2 DEFINITIONS .................................................................................................................. 2 ADVERSE EVENT REPORTING FOR ANIM AL DRUGS ....................................... 4 CANINE HEARTW ORM DISEASE.............................................................................. 7 M ACROCYCLIC LACTONES ...................................................................................... 8 PROHEART 6 PRODUCT INFORM ATION ............................................................... 8 REGULATORY HISTORY OF PROHEART 6 ......................................................... 10 ADE REPORTS FOR PROHEART 6 AND OTHER HEARTW ORM PREVENTIVES .............................................................................................................. 11 PROHEART 6 ADES ..................................................................................................... 16 TRENDS IN PROHEART 6 ADE REPORTING ....................................................... 19 CLINICAL M ANIFESTATIONS ................................................................................. 22 ANAPHYLAXIS/ANAPHYLACTOID REACTIONS ................................................................ 22 CONVULSIONS ................................................................................................................ 24 LIVER SIGNS.................................................................................................................. -
210867Orig1s000
CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 210867Orig1s000 OTHER REVIEW(S) Clinical Inspection Summary (CIS) NDA 210867 (Moxidectin) Clinical Inspection Summary Date May 31, 2018 From John Lee, M.D., Medical Officer Janice Pohlman, M.D., M.P.H., Team Leader Kassa Ayalew, M.D., M.P.H., Branch Chief Good Clinical Practice Assessment Branch (GCPAB) Division of Clinical Compliance Evaluation (DCCE) Office of Scientific Investigations (OSI) To Kristine Park, Ph.D., Regulatory Project Manager Hiwot Hiruwy, M.D., Ph.D., Medical Officer Dmitri Iarikov, M.D., Ph.D., Clinical Team Leader Sumati Nambiar, M.D., M.P.H., Director Division of Anti-Infective Products (DAIP) Application NDA 210867 Applicant Medicines Development for Global Health (MDGH) Drug Moxidectin (trade name pending) NME Yes Review Status Priority Proposed Indication Treatment of ochocerciasis due to Onchocerca volvulus Consultation Date December 15, 2017 CIS Goal Date June 1, 2018 Action Goal Date June 13, 2018 PDUFA Due Date June 13, 2018 I. OVERALL ASSESSMENT OF FINDINGS Studies 3110A1-200-GH and 3110A1-3000-AF/ONCBL60801 were audited at good clinical practice (GCP) inspections of a clinical investigator (CI) and a contract research organization (CRO). For both inspections, the establishment inspection report (EIR) has not been received from the field office and the inspection outcome shown is based on preliminary communication with the field investigator. Both inspections revealed significant GCP deficiencies, typically (apparently) deficiencies in recordkeeping (Form FDA 483 issued at CI inspection, not issued at CRO inspection). Evidence of serious deficiencies indicative of unreliable study data was not observed and study conduct otherwise appeared GCP-compliant. -
Comparative Genomics of the Major Parasitic Worms
Comparative genomics of the major parasitic worms International Helminth Genomes Consortium Supplementary Information Introduction ............................................................................................................................... 4 Contributions from Consortium members ..................................................................................... 5 Methods .................................................................................................................................... 6 1 Sample collection and preparation ................................................................................................................. 6 2.1 Data production, Wellcome Trust Sanger Institute (WTSI) ........................................................................ 12 DNA template preparation and sequencing................................................................................................. 12 Genome assembly ........................................................................................................................................ 13 Assembly QC ................................................................................................................................................. 14 Gene prediction ............................................................................................................................................ 15 Contamination screening ............................................................................................................................ -
I Comparative Activity of Anthelmintic
Retour au menu Comparative activity of anthelmintic drugs, mebendazole, praziquantel and albendazole against Hymenolepis M. Gala1 ’ diminufa in experimentally infected S. R. Chin ’ Irats GALAL (MT), CHIN (S. R.). Comparaison de l’action de différents CAVIER and ROSSIGNOL (3) studied the taenicidal anthelminttuques (mébendazole, praziquantel et albendazole) contre properties of albendazole, mebendazole, niclosamide Hymenoleph diminuta chez des rats expérimentalement Infectés. Rev. Elev. Méd. vét. Pays trop., 1987, 40 (2) : 147-150. and praziquantel in experimentally infected mice and found that praziquantel and niclosamide have similar Des rats expérimentalement infectés avec If. diminufa ont été traités par voie orale avec trois anthelminthiques, administrés soit en dose taenicidal propet-ties. unique, soit en tiers de dose 3 jours consécutifs. Le praziquantel (250 mgkg ou 83 mg/k&j 3 fois) et I’alhendazole (800 mgkg ou Now are reported the comparative efficacy of meben- 167 mgkg/j 3 fois) ont totalement éliminé les vers, alors que le dazole, praziquantel and albendazole against experi- mébendazole (500 rng/kg- - ou 167 mg/kg/i- -. 3 fois) ne les a aue oartielle- mental infection of rats with H. diminuta, using single ment éliminés, avec une efficacité de 76 p. 160. Parmi ces j anthel- and divided oral doses for 3 consecutive days, 30 days mlnthlques, il n’a pas été relevé de différence signiiïcative d’efkacité entre les différents dosages pour chaque traitement. Aucune toxicité after infection. n’est apparue chez les rats traités. Mots CES : Rat - Helminthosc - Hymenolepis diminuta - Anthelminthique - Mébendazole - Prazi- quantel - Albendazole - Infection expérimentale. MATERIALS AND METHODS INTRODUCTION Definitive and intermediate hosts Albino rats (Rattus norvegicus) of both sexes and H. -
Redalyc.Determination of Niclosamide and Its Metabolites in Liver And
Acta Scientiae Veterinariae ISSN: 1678-0345 [email protected] Universidade Federal do Rio Grande do Sul Brasil Kartalovic, Brankica; Pucarevic, Mira; Markovic, Zoran; Stankovic, Marko; Novakov, Nikolina; Pelic, Milos; Cirkovic, Miroslav Determination of Niclosamide and its Metabolites in Liver and Muscles of Common Carp (Cyprinus carpio) Fingerlings Acta Scientiae Veterinariae, vol. 45, 2017, pp. 1-6 Universidade Federal do Rio Grande do Sul Porto Alegre, Brasil Available in: http://www.redalyc.org/articulo.oa?id=289053641022 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative Acta Scientiae Veterinariae, 2017. 45: 1490. RESEARCH ARTICLE ISSN 1679-9216 Pub. 1490 Determination of Niclosamide and its Metabolites in Liver and Muscles of Common Carp (Cyprinus carpio) Fingerlings Brankica Kartalović1 , Mira Pucarević2, Zoran Marković3, Marko Stanković3, Nikolina Novakov4, Milos Pelić1 & Miroslav Ćirković1 ABSTRACT Background: Niclosamide is a medication used to treat tapeworm infestation in animals and humans. It is also lampricide and molluscicide, and can be used in in agriculture as a pesticide. In the treatment of parasitic diseases in fish, niclosamide can be used as bath or mixed with the feed. Its most important use in common carp (Cyprinus carpio) is for the treatment of Bothriocephalus acheilognathi, which is a very common parasite in this fish species. The aim of this study was to de- termine the concentrations of niclosamide (NIC) and its metabolite 2-chloro 4-nitro aniline (CNA) and 5-chloro salycilic acid (CSA) in the liver and muscles of common carp fingerlings. -
Efficacy of Albendazole and Moxidectin and Resistance To
Veterinary Parasitology 189 (2012) 387–389 Contents lists available at SciVerse ScienceDirect Veterinary Parasitology jo urnal homepage: www.elsevier.com/locate/vetpar Short communication Efficacy of albendazole and moxidectin and resistance to ivermectin against Libyostrongylus douglassii and Libyostrongylus dentatus in ostriches a a b Lara Pereira de Souza , Rosane Teixeira Lelis , Igor Rio Apa Granja , a a,∗ Renato Augusto DaMatta , Clóvis de Paula Santos a Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense, 28013-602 Campos dos Goytacazes, RJ, Brazil b Rioapavestruzes, 28013-600 Guarani, MG, Brazil a r t i c l e i n f o a b s t r a c t Article history: Anthelmintic resistance has emerged globally as a problem amongst nematode of livestock Received 17 February 2012 and has been particularly well documented in equine and small ruminants. There are no Received in revised form 18 April 2012 studies regarding the efficacy of anthelmintics against the hematophagous nematodes in Accepted 20 April 2012 ostriches, Libyostrongylus dentatus; and just a few on L. douglassii. Here the efficacy of alben- dazole, ivermectin and moxidectin were evaluated against these two species in an ostrich Keywords: farm in Minas Gerais state, Brazil. The feces were collected on the day of treatment and Libyostrongylus douglassii after 13 days of an oral dose of albendazole (6 mg/kg), or an injected dose (0.2 mg/kg) of Libyostrongylus dentatus ivermectin or moxidectin. The fecal egg count reduction test and coprocultures were per- Anthelmintic resistance Ostrich formed to determine possible resistance against the drugs used. -
Parasiticides: Fenbendazole, Ivermectin, Moxidectin Livestock
Parasiticides: Fenbendazole, Ivermectin, Moxidectin Livestock 1 Identification of Petitioned Substance* 2 3 Chemical Names: 48 Ivermectin: Heart Guard, Sklice, Stomectol, 4 Moxidectin:(1'R,2R,4Z,4'S,5S,6S,8'R,10'E,13'R,14'E 49 Ivomec, Mectizan, Ivexterm, Scabo 6 5 ,16'E,20'R,21'R,24'S)-21',24'-Dihydroxy-4 50 Thiabendazole: Mintezol, Tresaderm, Arbotect 6 (methoxyimino)-5,11',13',22'-tetramethyl-6-[(2E)- 51 Albendazole: Albenza 7 4-methyl-2-penten-2-yl]-3,4,5,6-tetrahydro-2'H- 52 Levamisole: Ergamisol 8 spiro[pyran-2,6'-[3,7,1 9]trioxatetracyclo 53 Morantel tartrate: Rumatel 9 [15.6.1.14,8.020,24] pentacosa[10,14,16,22] tetraen]- 54 Pyrantel: Banminth, Antiminth, Cobantril 10 2'-one; (2aE, 4E,5’R,6R,6’S,8E,11R,13S,- 55 Doramectin: Dectomax 11 15S,17aR,20R,20aR,20bS)-6’-[(E)-1,2-Dimethyl-1- 56 Eprinomectin: Ivomec, Longrange 12 butenyl]-5’,6,6’,7,10,11,14,15,17a,20,20a,20b- 57 Piperazine: Wazine, Pig Wormer 13 dodecahydro-20,20b-dihydroxy-5’6,8,19-tetra- 58 14 methylspiro[11,15-methano-2H,13H,17H- CAS Numbers: 113507-06-5; 15 furo[4,3,2-pq][2,6]benzodioxacylooctadecin-13,2’- Moxidectin: 16 [2H]pyrano]-4’,17(3’H)-dione,4’-(E)-(O- Fenbendazole: 43210-67-9; 70288-86-7 17 methyloxime) Ivermectin: 59 Thiabendazole: 148-79-8 18 Fenbendazole: methyl N-(6-phenylsulfanyl-1H- 60 Albendazole: 54965-21-8 19 benzimidazol-2-yl) carbamate 61 Levamisole: 14769-72-4 20 Ivermectin: 22,23-dihydroavermectin B1a +22,23- 21 dihydroavermectin B1b 62 Morantel tartrate: 26155-31-7 63 Pyrantel: 22204-24-6 22 Thiabendazole: 4-(1H-1,3-benzodiazol-2-yl)-1,3- 23 thiazole -
Tutorial Article a Review of the Use of Moxidectin in Horses J
EVE 08-054 Schumacher 17/9/08 09:34 Page 2 546 EQUINE VETERINARY EDUCATION / AE / october 2008 Tutorial Article A review of the use of moxidectin in horses J. SCHUMACHER* AND J. TAINTOR Department of Clinical Sciences, J.T. Vaughan Teaching Hospital, College of Veterinary Medicine, Auburn University, Alabama, 36849-5522, USA. Keywords: horse; moxidectin; ivermectin; cyathostomins; ascarids; ectoparasites; resistance Summary which are produced naturally from soil-dwelling Streptomyces microorganisms, are divided into 2 classes of anti-parasitic Moxidectin has broad-spectrum anti-nematodal and drugs, the avermectins and the milbemycins. The first anti-arthropodal activities in the horse but is not macrocyclic lactone introduced to the equine market was the effective against tapeworms or flukes. Moxidectin and avermectin, ivermectin, which was introduced in 1981. That ivermectin have the same efficacy against internal, adult drug revolutionised control of endoparasites and ectoparasites parasites of horses. Moxidectin, however, is highly in many different species because of its relative safety and effective in eliminating encysted and hypobiotic larval efficacy against most economically important parasitic stages of cyathostomins, whereas ivermectin is not. diseases. Since the introduction of ivermectin, other Treatment of horses with moxidectin results in an egg- macrocyclic lactones have been introduced, including reappearance period (ERP) of 15–24 weeks. Because of albamectin, eprinomectin, doramectin, selamectin, moxidectin its long ERP, moxidectin is labelled to be used at and milbemycin A3/A4. Ivermectin, albamectin and 12 week intervals. Moxidectin may provide protection moxidectin are marketed for use in horses. against infection by ingested cyathostomin larvae for 2–3 weeks after it is administered. -
Sheet1 Page 1 a Abamectin Acetazolamide Sodium Adenosine-5-Monophosphate Aklomide Albendazole Alfaxalone Aloe Vera Alphadolone A
Sheet1 A Abamectin Acetazolamide sodium Adenosine-5-monophosphate Aklomide Albendazole Alfaxalone Aloe vera Alphadolone Acetate Alpha-galactosidase Altrenogest Amikacin and its salts Aminopentamide Aminopyridine Amitraz Amoxicillin Amphomycin Amphotericin B Ampicillin Amprolium Anethole Apramycin Asiaticoside Atipamezole Avoparcin Azaperone B Bambermycin Bemegride Benazepril Benzathine cloxacillin Benzoyl Peroxide Benzydamine Bephenium Bephenium Hydroxynaphthoate Betamethasone Boldenone undecylenate Boswellin Bromelain Bromhexine 2-Bromo-2-nitropan-1, 3 diol Bunamidine Buquinolate Butamisole Butonate Butorphanol Page 1 Sheet1 C Calcium glucoheptonate (calcium glucoheptogluconate) Calcium levulinate Cambendazole Caprylic/Capric Acid Monoesters Carbadox Carbomycin Carfentanil Carnidazole Carnitine Carprofen Cefadroxil Ceftiofur sodium Centella asiatica Cephaloridine Cephapirin Chlorine dioxide Chlormadinone acetate Chlorophene Chlorothiazide Chlorpromazine HCl Choline Salicylate Chondroitin sulfate Clazuril Clenbuterol Clindamycin Clomipramine Clopidol Cloprostenol Clotrimazole Cloxacillin Colistin sulfate Copper calcium edetate Copper glycinate Coumaphos Cromolyn sodium Crystalline Hydroxycobalamin Cyclizine Cyclosporin A Cyprenorphine HCl Cythioate D Decoquinate Demeclocycline (Demethylchlortetracycline) Page 2 Sheet1 Deslorelin Desoxycorticosterone Pivalate Detomidine Diaveridine Dichlorvos Diclazuril Dicloxacillin Didecyl dimethyl ammonium chloride Diethanolamine Diethylcarbamazine Dihydrochlorothiazide Diidohydroxyquin Dimethylglycine -
Pest Management Strategic Plan for Beef Cattle in Tennessee and Kentucky
Pest Management Strategic Plan for Beef Cattle in Tennessee and Kentucky Summary of Workshops held in January 2005 Princeton, KY and Nashville, TN Prepared by J. Patrick Parkman, IPM Coordinator University of Tennessee Institute of Agriculture Contact: J. Patrick Parkman (865) 974-7138 [email protected] Sponsored by the Southern Region Integrated Pest Management Center, USDA Cooperative State Research, Education and Extension Service Executive Summary With a combined total of 2,238,000 beef cows, Kentucky and Tennessee are the top two beef cattle production states east of the Mississippi. Cash receipts for cattle and calves sales in 2004 totaled $620,650,000 for Kentucky (15% of all receipts) and $514,338,000 for Tennessee (20% of all receipts). In Tennessee, cattle and calves is the leading agricultural commodity. The significance of this industry underscores the importance of reviewing the status of beef cattle pest management in these states and making recommendations for improvement. This document presents the conclusions of two one-day meetings involving producers and state Extension personnel. The meetings were held in response to regulatory actions such as the Food Quality Protection Act which may affect availability of pest management products; to the emergence of new technologies; and to ongoing and new threats to the industry such as pesticide resistance and increased pest pressure. The document includes an overview of production practices, pest incidence and importance, and current pest management practices. Arthropods are far and away the most important pest of cattle in these states, therefore, these pests are given the most emphasis. The priorities developed by meeting participants and published here should serve as a guideline to researchers, Extension personnel, regulators and industry leaders when addressing pest management issues facing beef cattle producers in Kentucky and Tennessee.