(ESI) for Integrative Biology. This Journal Is © the Royal Society of Chemistry 2017

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Electronic Supplementary Material (ESI) for Integrative Biology. This journal is © The Royal Society of Chemistry 2017

Table 1 Enriched GO terms with p-value ≤ 0.05 corresponding to the over-expressed genes upon perturbation with the lung-toxic compounds. Terms with corrected p-value less than 0.001 are shown in bold.

GO:0043067 regulation of programmed GO:0010941 regulation of cell death cell death GO:0042981 regulation of apoptosis GO:0010033 response to organic sub- stance GO:0043068 positive regulation of pro- GO:0010942 positive regulation of cell grammed cell death death GO:0006357 regulation of transcription GO:0043065 positive regulation of apop- from RNA polymerase II promoter tosis GO:0010035 response to inorganic sub- GO:0043066 negative regulation of stance apoptosis GO:0043069 negative regulation of pro- GO:0060548 negative regulation of cell death grammed cell death GO:0016044 membrane organization GO:0042592 homeostatic process GO:0010629 negative regulation of gene ex- GO:0001568 blood vessel development pression GO:0051172 negative regulation of nitrogen GO:0006468 protein amino acid phosphoryla- compound metabolic process tion GO:0070482 response to oxygen levels GO:0045892 negative regulation of transcription, DNA-dependent GO:0001944 vasculature development GO:0046907 intracellular transport GO:0008202 steroid metabolic process GO:0045934 negative regulation of nucle- obase, nucleoside, nucleotide and nucleic acid metabolic process GO:0006917 induction of apoptosis GO:0016481 negative regulation of transcription GO:0016125 sterol metabolic process GO:0012502 induction of programmed cell death GO:0001666 response to hypoxia GO:0051253 negative regulation of RNA metabolic process GO:0008203 cholesterol metabolic process GO:0010551 regulation of speciﬁc transcription from RNA polymerase II promoter

1 Table 2 Enriched GO terms with p-value ≤ 0.05 corresponding to the under-expressed genes upon perturbation with the lung-toxic compounds. Terms with corrected p-value less than 0.001 are shown in bold.

GO:0022403 cell cycle phase GO:0022402 cell cycle process GO:0000278 mitotic cell cycle GO:0007049 cell cycle GO:0000279 M phase GO:0046907 intracellular transport GO:0048285 organelle ﬁssion GO:0051329 interphase of mitotic cell cycle GO:0043068 positive regulation of pro- GO:0010942 positive regulation of cell grammed cell death death GO:0051325 interphase GO:0051726 regulation of cell cycle GO:0043065 positive regulation of apop- GO:0000087 M phase of mitotic cell cy- tosis cle GO:0051301 cell division GO:0000280 nuclear division GO:0007067 mitosis GO:0033554 cellular response to stress GO:0032268 regulation of cellular protein GO:0043067 regulation of programmed cell metabolic process death GO:0010941 regulation of cell death GO:0006468 protein amino acid phosphorylation GO:0042981 regulation of apoptosis GO:0006974 response to DNA damage stimu- lus GO:0006350 transcription GO:0080135 regulation of cellular response to stress GO:0010564 regulation of cell cycle process GO:0009057 macromolecule catabolic process GO:0032774 RNA biosynthetic process GO:0016310 phosphorylation GO:0051276 chromosome organization GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0010605 negative regulation of macro- GO:0007059 chromosome segregation molecule metabolic process GO:0006913 nucleocytoplasmic transport

2 Table 3 Detailed results using the CMAP query tool for identifying drugs whose gene expression signatures have positive or negative correlation to the search query. As a search query the top 500 over- and under-expressed genes were used. The CMAP query tool scored every instance according to its correlation to the search query and sorted the output in descending order. For more details see https://www.broadinstitute.org/cmap

rank batch cmap name dose cell score instance id 1 636 tamoxifen 7 µM MCF7 1 2212 2 626 thioridazine 10 µM MCF7 0.988 1655 3 725 thioridazine 10 µM MCF7 0.964 5227 4 636 terfenadine 8 µM MCF7 0.963 2227 5 730 metergoline 10 µM MCF7 0.96 5344 6 506 trifluoperazine 10 µM MCF7 0.956 1004 7 506 thioridazine 10 µM MCF7 0.944 1010 8 691 trimipramine 10 µM MCF7 0.943 4163 9 657 prenylamine 10 µM MCF7 0.942 2886 10 744 terfenadine 8 µM MCF7 0.941 6823 11 765 prochlorperazine 10 µM MCF7 0.926 6975 12 771 perhexiline 10 µM MCF7 0.925 7441 13 726 loperamide 8 µM MCF7 0.924 5267 14 505 calmidazolium 5 µM MCF7 0.924 906 15 736 pyrvinium 3 µM MCF7 0.92 5439 16 727 thioridazine 10 µM PC3 0.919 4454 17 731 mefloquine 10 µM PC3 0.919 5724 18 712 tonzonium bromide 7 µM PC3 0.919 4617 19 744 clomipramine 11 µM MCF7 0.917 6825 20 700 cloperastine 11 µM MCF7 0.917 4732 21 505 trifluoperazine 10 µM MCF7 0.914 910 22 755 fluspirilene 8 µM MCF7 0.914 6463 23 636 astemizole 9 µM MCF7 0.914 2211 24 699 alexidine 7 µM MCF7 0.913 4721 25 757 thioridazine 10 µM MCF7 0.913 5590 26 603 thioridazine 10 µM PC3 0.912 1230 27 755 tonzonium bromide 7 µM MCF7 0.912 6457 28 663 rescinnamine 6 µM MCF7 0.912 2785 29 744 astemizole 9 µM MCF7 0.911 6807 30 707 suloctidil 12 µM MCF7 0.909 5021 31 691 thioridazine 10 µM MCF7 0.909 4164 32 725 prochlorperazine 10 µM MCF7 0.908 5212 33 636 mefloquine 10 µM MCF7 0.908 2210 34 725 trifluoperazine 10 µM MCF7 0.906 5221 35 657 mometasone 8 µM MCF7 0.905 2896

3 36 727 trifluoperazine 10 µM PC3 0.9 4448 37 603 trifluoperazine 10 µM PC3 0.899 1224 38 506 fluphenazine 10 µM MCF7 0.895 1017 39 626 trifluoperazine 10 µM MCF7 0.895 1649 40 707 amoxapine 13 µM MCF7 0.894 4996 41 502 rottlerin 10 µM MCF7 0.892 941 42 755 phenoxybenzamine 12 µM MCF7 0.889 6451 43 502 resveratrol 10 µM MCF7 0.885 958 44 767 fluphenazine 10 µM MCF7 0.876 6954 45 707 fluspirilene 8 µM MCF7 0.874 5008 46 736 protriptyline 13 µM MCF7 0.871 5438 47 741 homochlorcyclizine 10 µM MCF7 0.871 5998 48 736 trifluoperazine 8 µM MCF7 0.87 5442 49 745 mefloquine 10 µM MCF7 0.87 6205 50 646 pimozide 9 µM MCF7 0.867 3178 51 728 astemizole 9 µM PC3 0.866 4471 52 743 pimozide 9 µM MCF7 0.865 6780 53 708 bepridil 10 µM MCF7 0.863 5674 54 506 prochlorperazine 10 µM MCF7 0.863 995 55 707 clomifene 7 µM MCF7 0.863 4994 56 502 pyrvinium 1 µM MCF7 0.863 978 57 736 propafenone 11 µM MCF7 0.862 5437 58 737 perhexiline 10 µM MCF7 0.859 5501 59 682 methylbenzethonium 9 µM PC3 0.858 3768 chloride 60 752 tetrandrine 6 µM MCF7 0.857 6082 61 747 proadifen 10 µM MCF7 0.857 7165 62 743 tamoxifen 7 µM MCF7 0.856 6768 63 637 antimycin A 7 µM MCF7 0.853 2261 64 632 niclosamide 12 µM MCF7 0.849 1498 65 771 trichostatin A 100 nM MCF7 0.849 7407 66 748 benzethonium chlo- 9 µM MCF7 0.848 7207 ride 67 505 ionomycin 2 µM MCF7 0.841 882 68 633 loperamide 8 µM MCF7 0.841 1533 69 633 perphenazine 10 µM MCF7 0.841 1540 70 726 phenoxybenzamine 12 µM MCF7 0.838 5248 71 771 nortriptyline 13 µM MCF7 0.837 7422 72 771 trifluoperazine 8 µM MCF7 0.837 7420 73 632 miconazole 10 µM MCF7 0.836 1477 74 758 loperamide 8 µM MCF7 0.833 5632 75 731 syrosingopine 6 µM PC3 0.832 5733

4 76 685 cloperastine 11 µM MCF7 0.832 3608 77 705 rescinnamine 6 µM MCF7 0.83 4386 78 757 prochlorperazine 10 µM MCF7 0.827 5575 79 655 amiodarone 6 µM MCF7 0.826 3296 80 751 methylbenzethonium 9 µM MCF7 0.826 6045 chloride 81 758 phenoxybenzamine 12 µM MCF7 0.825 5613 82 729 promethazine 12 µM MCF7 0.824 5317 83 681 cloperastine 11 µM PC3 0.824 3710 84 603 prochlorperazine 10 µM PC3 0.823 1215 85 757 15-delta 10 µM MCF7 0.823 5591 prostaglandin J2 86 636 ivermectin 5 µM MCF7 0.82 2213 87 737 prenylamine 10 µM MCF7 0.819 5489 88 718 prenylamine 10 µM PC3 0.819 5070 89 632 thioridazine 10 µM MCF7 0.817 1486 90 698 alexidine 7 µM PC3 0.815 7397 91 619 trifluoperazine 8 µM HL60 0.815 2389 92 736 amitriptyline 13 µM MCF7 0.815 5453 93 707 sulconazole 9 µM MCF7 0.815 4998 94 689 trimipramine 10 µM PC3 0.814 4083 95 727 prochlorperazine 10 µM PC3 0.813 4439 96 727 fluphenazine 10 µM PC3 0.813 4461 97 707 maprotiline 13 µM MCF7 0.813 5022 98 653 bepridil 10 µM MCF7 0.811 2629 99 711 methylbenzethonium 9 µM MCF7 0.811 3943 chloride 100 670 cloperastine 11 µM MCF7 0.811 3408 101 730 lynestrenol 14 µM MCF7 0.809 5355 102 741 nortriptyline 13 µM MCF7 0.809 6003 103 729 desipramine 13 µM MCF7 0.808 5292 104 616 mefloquine 10 µM PC3 0.808 2048 105 656 thiostrepton 2 µM MCF7 0.807 2823 106 603 fluphenazine 10 µM PC3 0.807 1237 107 772 Prestwick-559 8 µM MCF7 0.807 7462 108 711 promazine 12 µM MCF7 0.806 3927 109 706 miconazole 10 µM MCF7 0.804 4960 110 656 norcyclobenzaprine 15 µM MCF7 0.804 2830 111 752 benzethonium chlo- 9 µM MCF7 0.804 6070 ride 112 702 methylbenzethonium 9 µM PC3 0.802 4325 chloride

5 113 705 thiostrepton 2 µM MCF7 0.799 4385 114 735 hexetidine 12 µM MCF7 0.799 5420 115 729 puromycin 7 µM MCF7 0.798 5310 116 505 pararosaniline 10 µM MCF7 0.796 893 117 677 pyrvinium 3 µM MCF7 0.795 3518 118 694 norcyclobenzaprine 15 µM MCF7 0.794 4776 119 730 trichostatin A 100 nM MCF7 0.793 5336 120 689 thioridazine 10 µM PC3 0.791 4085 121 772 pimethixene 10 µM MCF7 0.791 7468 122 765 thioridazine 10 µM MCF7 0.788 6989 123 692 norcyclobenzaprine 15 µM PC3 0.787 4190 124 626 15-delta 10 µM MCF7 0.787 1656 prostaglandin J2 125 687 fenbendazole 13 µM MCF7 0.787 3888 126 505 celastrol 3 µM MCF7 0.786 887 127 682 promazine 12 µM PC3 0.786 3752 128 745 disulfiram 13 µM MCF7 0.786 6210 129 771 homochlorcyclizine 10 µM MCF7 0.785 7417 130 754 pyrvinium 3 µM PC3 0.784 6339 131 729 flupentixol 8 µM MCF7 0.784 5307 132 701 cloperastine 11 µM PC3 0.783 4271 133 771 econazole 9 µM MCF7 0.782 7427 134 505 5109870 25 µM MCF7 0.782 904 135 713 clioquinol 13 µM PC3 0.782 4663 136 731 thiethylperazine 6 µM PC3 0.782 5756 137 690 niclosamide 12 µM MCF7 0.78 4136 138 758 clioquinol 13 µM MCF7 0.779 5623 139 730 cyproheptadine 12 µM MCF7 0.778 5340 140 714 flupentixol 8 µM PC3 0.778 6708 141 713 phenoxybenzamine 12 µM PC3 0.778 4652 142 745 phenazopyridine 16 µM MCF7 0.777 6234 143 673 sulconazole 9 µM MCF7 0.776 3373 144 771 flunarizine 8 µM MCF7 0.776 7412 145 750 thioridazine 10 µM HL60 0.775 6189 146 708 tonzonium bromide 7 µM MCF7 0.775 5678 147 653 chlorprothixene 11 µM MCF7 0.774 2627 148 757 fulvestrant 1 µM MCF7 0.774 5565 149 747 tetrandrine 6 µM MCF7 0.773 7178 150 714 desipramine 13 µM PC3 0.772 6693 151 662 syrosingopine 6 µM MCF7 0.772 2753 152 663 trichostatin A 100 nM MCF7 0.771 2794

6 153 725 trichostatin A 100 nM MCF7 0.77 5209 154 772 triflupromazine 10 µM MCF7 0.77 7466 155 687 chlorcyclizine 12 µM MCF7 0.769 3893 156 744 clofilium tosylate 8 µM MCF7 0.769 6830 157 678 sertaconazole 8 µM MCF7 0.769 3550 158 741 econazole 9 µM MCF7 0.769 6008 159 626 tanespimycin 1 µM MCF7 0.769 1651 160 737 chlorpromazine 11 µM MCF7 0.769 5493 161 754 trifluoperazine 8 µM PC3 0.768 6341 162 616 astemizole 9 µM PC3 0.767 2049 163 653 clomifene 7 µM MCF7 0.766 2624 164 707 progesterone 13 µM MCF7 0.766 4992 165 772 clemastine 9 µM MCF7 0.766 7485 166 626 prochlorperazine 10 µM MCF7 0.765 1640 167 702 promazine 12 µM PC3 0.765 4308 168 746 nicergoline 8 µM MCF7 0.765 6251 169 707 prochlorperazine 7 µM MCF7 0.765 5010 170 731 raloxifene 8 µM PC3 0.764 5759 171 707 thioguanosine 13 µM MCF7 0.763 4989 172 765 trifluoperazine 10 µM MCF7 0.762 6984 173 744 verteporfin 3 µM MCF7 0.762 6817 174 692 quinisocaine 13 µM PC3 0.761 4207 175 741 dosulepin 12 µM MCF7 0.761 5986 176 757 fluphenazine 10 µM MCF7 0.761 5597 177 680 alexidine 7 µM PC3 0.76 3699 178 502 wortmannin 1 µM MCF7 0.76 977 179 713 loperamide 8 µM PC3 0.76 4672 180 671 trichostatin A 100 nM MCF7 0.76 3462 181 626 troglitazone 10 µM MCF7 0.759 1657 182 603 LY-294002 10 µM PC3 0.759 1236 183 671 drofenine 11 µM MCF7 0.759 3455 184 748 abamectin 5 µM MCF7 0.759 7218 185 718 chlorpromazine 11 µM PC3 0.758 5074 186 619 pergolide 10 µM HL60 0.758 2403 187 735 metitepine 8 µM MCF7 0.758 5413 188 504 wortmannin 1 µM MCF7 0.758 869 189 627 noretynodrel 13 µM MCF7 0.757 1696 190 753 azacyclonol 15 µM PC3 0.757 6298 191 699 clemizole 11 µM MCF7 0.756 4695 192 695 simvastatin 10 µM MCF7 0.756 4828 193 772 bromperidol 10 µM MCF7 0.755 7457

7 194 626 vorinostat 10 µM MCF7 0.755 1645 195 657 parthenolide 16 µM MCF7 0.755 2885 196 632 trichostatin A 100 nM MCF7 0.754 1471 197 616 ivermectin 5 µM PC3 0.753 2051 198 636 ursolic acid 9 µM MCF7 0.753 2230 199 736 imipramine 13 µM MCF7 0.753 5440 200 730 propranolol 14 µM MCF7 0.753 5358 201 670 monensin 6 µM MCF7 0.752 3443 202 700 benzamil 11 µM MCF7 0.752 4760 203 725 sirolimus 100 nM MCF7 0.752 5204 204 765 tanespimycin 1 µM MCF7 0.752 6985 205 655 butoconazole 8 µM MCF7 0.752 3288 206 629 8-azaguanine 26 µM HL60 0.751 1833 207 747 fendiline 11 µM MCF7 0.751 7188 208 653 suloctidil 12 µM MCF7 0.75 2651 209 726 haloperidol 11 µM MCF7 0.749 5273 210 506 trichostatin A 100 nM MCF7 0.749 992 211 504 carbamazepine 100 nM MCF7 0.749 835 212 748 alimemazine 5 µM MCF7 0.749 7235 213 664 meptazinol 15 µM HL60 0.748 2906 214 765 15-delta 10 µM MCF7 0.748 6990 prostaglandin J2 215 712 perphenazine 10 µM PC3 0.748 4637 216 502 5253409 17 µM MCF7 0.748 961 217 748 isoconazole 10 µM MCF7 0.748 7211 218 767 troglitazone 10 µM MCF7 0.746 6949 219 726 meclozine 9 µM MCF7 0.746 5244 220 506 15-delta 10 µM MCF7 0.745 1011 prostaglandin J2 221 757 LY-294002 10 µM MCF7 0.745 5596 222 745 syrosingopine 6 µM MCF7 0.744 6213 223 602 trichostatin A 100 nM HL60 0.744 1153 224 732 spiperone 10 µM PC3 0.743 5777 225 729 felodipine 10 µM MCF7 0.742 5294 226 648 tetryzoline 17 µM HL60 0.742 2507 227 726 clioquinol 13 µM MCF7 0.742 5258 228 502 trichostatin A 1 µM MCF7 0.741 981 229 765 LY-294002 10 µM MCF7 0.741 6987 230 670 medrysone 12 µM MCF7 0.741 3403 231 646 clotrimazole 12 µM MCF7 0.741 3166

8 232 502 5224221 12 µM MCF7 0.741 956 233 683 chlorcyclizine 12 µM PC3 0.74 3810 234 626 fluphenazine 10 µM MCF7 0.74 1662 235 626 geldanamycin 1 µM MCF7 0.74 1653 236 765 fulvestrant 1 µM MCF7 0.739 6965 237 746 fluorometholone 11 µM MCF7 0.738 6247 238 505 5114445 10 µM MCF7 0.738 901 239 626 tanespimycin 1 µM MCF7 0.738 1643 240 636 nicergoline 8 µM MCF7 0.738 2220 241 725 sirolimus 100 nM MCF7 0.737 5218 242 767 tanespimycin 1 µM MCF7 0.737 6926 243 748 fluphenazine 8 µM MCF7 0.737 7234 244 671 dienestrol 15 µM MCF7 0.736 3448 245 649 mephentermine 9 µM HL60 0.736 2563 246 772 penbutolol 6 µM MCF7 0.736 7476 247 734 ivermectin 5 µM PC3 0.735 5853 248 662 piperlongumine 13 µM MCF7 0.735 2757 249 719 deptropine 8 µM PC3 0.734 5118 250 747 albendazole 15 µM MCF7 0.734 7164 251 747 piperacetazine 10 µM MCF7 0.734 7191 252 729 propofol 22 µM MCF7 0.734 5306 253 513 prochlorperazine 10 µM MCF7 0.734 1053 254 725 fluphenazine 10 µM MCF7 0.733 5234 255 706 lasalocid 7 µM MCF7 0.733 4985 256 765 trichostatin A 100 nM MCF7 0.733 6972 257 751 famprofazone 11 µM MCF7 0.733 6029 258 504 pyrvinium 1 µM MCF7 0.733 870 259 727 LY-294002 10 µM PC3 0.733 4451 260 670 ethoxyquin 18 µM MCF7 0.732 3421 261 728 clomipramine 11 µM PC3 0.732 4487 262 505 clotrimazole 50 µM MCF7 0.731 905 263 713 amiodarone 6 µM PC3 0.731 4657 264 671 raloxifene 8 µM MCF7 0.73 3480 265 703 withaferin A 1 µM PC3 0.73 4554 266 505 colforsin 50 µM MCF7 0.729 913 267 505 rottlerin 10 µM MCF7 0.729 914 268 657 trichostatin A 100 nM MCF7 0.729 2881 269 745 raloxifene 8 µM MCF7 0.729 6235 270 735 dequalinium chlo- 8 µM MCF7 0.728 5396 ride 271 670 trichostatin A 100 nM MCF7 0.728 3428

9 272 729 danazol 12 µM MCF7 0.728 5315 273 730 fluoxetine 12 µM MCF7 0.728 5356 274 506 wortmannin 10 nM MCF7 0.727 1023 275 756 protriptyline 13 µM MCF7 0.727 6498 276 687 withaferin A 1 µM MCF7 0.727 3902 277 671 ebselen 15 µM MCF7 0.727 3458 278 642 mebendazole 14 µM MCF7 0.727 2300 279 729 chlorprothixene 11 µM MCF7 0.727 5291 280 602 tretinoin 1 µM HL60 0.727 1152 281 725 tanespimycin 1 µM MCF7 0.726 5203 282 744 oxyphenbutazone 12 µM MCF7 0.725 6844 283 655 meclozine 9 µM MCF7 0.725 3285 284 765 tanespimycin 1 µM MCF7 0.724 6978 285 757 LY-294002 10 µM MCF7 0.724 5587 286 698 levomepromazine 9 µM PC3 0.724 7399 287 756 trichostatin A 100 nM MCF7 0.724 6493 288 505 HC toxin 100 nM MCF7 0.724 909 289 710 maprotiline 13 µM PC3 0.724 6676 290 686 methylbenzethonium 9 µM MCF7 0.723 3850 chloride 291 657 dosulepin 12 µM MCF7 0.723 2864 292 506 genistein 10 µM MCF7 0.723 1015 293 734 fluphenazine 8 µM PC3 0.722 5880 294 750 prochlorperazine 10 µM HL60 0.722 6174 295 678 ronidazole 20 µM MCF7 0.721 3557 296 504 oxaprozin 300 µM MCF7 0.721 863 297 645 gossypol 8 µM HL60 0.72 2202 298 707 clorgiline 13 µM MCF7 0.719 5005 299 626 LY-294002 10 µM MCF7 0.718 1661 300 683 fenbendazole 13 µM PC3 0.718 3805 301 506 troglitazone 10 µM MCF7 0.718 1012 302 655 puromycin 7 µM MCF7 0.717 3310 303 754 protriptyline 13 µM PC3 0.717 6338 304 647 metergoline 10 µM MCF7 0.717 3221 305 734 alimemazine 5 µM PC3 0.717 5881 306 655 felodipine 10 µM MCF7 0.716 3295 307 765 tanespimycin 1 µM MCF7 0.716 6986 308 1057 0297417-0002B 10 µM MCF7 0.716 6902 309 653 dequalinium chlo- 8 µM MCF7 0.715 2631 ride 310 766 naftifine 12 µM MCF7 0.715 7032 311 757 sirolimus 100 nM MCF7 0.715 5567

10 312 506 sirolimus 100 nM MCF7 0.715 1001 313 757 tanespimycin 1 µM MCF7 0.715 5586 314 504 resveratrol 10 µM MCF7 0.715 841 315 619 perhexiline 10 µM HL60 0.715 2410 316 765 alvespimycin 100 nM MCF7 0.714 6973 317 720 chlorcyclizine 12 µM MCF7 0.714 4367 318 753 butoconazole 8 µM PC3 0.714 6288 319 743 oxybutynin 10 µM MCF7 0.714 6770 320 665 iopanoic acid 7 µM HL60 0.713 2965 321 653 thioguanosine 13 µM MCF7 0.713 2619 322 664 zalcitabine 19 µM HL60 0.712 2932 323 619 minocycline 8 µM HL60 0.712 2405 324 766 ﬂunarizine 8 µM MCF7 0.712 7013 325 728 acepromazine 9 µM PC3 0.712 4494 326 705 ciclosporin 3 µM MCF7 0.712 4411 327 506 tanespimycin 1 µM MCF7 0.711 1005 328 665 pyrvinium 3 µM HL60 0.711 2957 329 762 nortriptyline 13 µM PC3 0.711 7300 330 655 hexetidine 12 µM MCF7 0.711 3318 331 743 drofenine 11 µM MCF7 0.711 6776 332 757 trichostatin A 100 nM MCF7 0.711 5572 333 647 vanoxerine 8 µM MCF7 0.71 3240 334 767 haloperidol 10 µM MCF7 0.71 6923 335 664 ﬂuticasone 8 µM HL60 0.71 2928 336 506 fulvestrant 1 µM MCF7 0.71 985 337 1003 thioridazine 10 µM PC3 0.709 5921 338 663 quinisocaine 13 µM MCF7 0.709 2807 339 714 chlorprothixene 11 µM PC3 0.709 6692 340 730 rolipram 15 µM MCF7 0.709 5330 341 502 carbamazepine 100 nM MCF7 0.708 952 342 646 etacrynic acid 13 µM MCF7 0.708 3181 343 506 LY-294002 10 µM MCF7 0.708 1019 344 707 metixene 12 µM MCF7 0.707 5018 345 747 tomatidine 10 µM MCF7 0.706 7166 346 719 parthenolide 16 µM PC3 0.706 5105 347 506 alvespimycin 100 nM MCF7 0.706 993 348 772 trichostatin A 100 nM MCF7 0.706 7453 349 712 bepridil 10 µM PC3 0.706 4613 350 647 clorgiline 13 µM MCF7 0.706 3219 351 758 amiodarone 6 µM MCF7 0.705 5618 352 502 quinostatin 10 µM MCF7 0.705 973

11 353 751 gossypol 8 µM MCF7 0.705 6058 354 626 sirolimus 100 nM MCF7 0.705 1646 355 753 dequalinium chlo- 8 µM PC3 0.704 6296 ride 356 710 prochlorperazine 7 µM PC3 0.704 6664 357 506 LY-294002 10 µM MCF7 0.704 1007 358 715 metergoline 10 µM PC3 0.704 6744 359 758 trichostatin A 100 nM MCF7 0.703 5625 360 678 triﬂuridine 14 µM MCF7 0.703 3559 361 767 tanespimycin 1 µM MCF7 0.703 6937 362 676 tracazolate 12 µM MCF7 0.703 7339 363 680 mebendazole 14 µM PC3 0.702 3671 364 731 phenazopyridine 16 µM PC3 0.702 5758 365 712 bisacodyl 11 µM PC3 0.701 4616 366 634 menadione 23 µM HL60 0.701 2439 367 630 suloctidil 12 µM HL60 0.701 1297 368 504 5224221 12 µM MCF7 0.7 839 369 665 pivampicillin 9 µM HL60 0.7 2945 370 633 bromocriptine 5 µM MCF7 0.7 1507 371 659 luteolin 14 µM HL60 0.7 3041 372 1071 MS-275 10 µM PC3 0.7 7074 373 744 cyproterone 10 µM MCF7 0.699 6806 374 766 talampicillin 8 µM MCF7 0.699 7014 375 672 simvastatin 10 µM MCF7 0.699 3340 376 730 desoxycortone 12 µM MCF7 0.698 5357 377 677 trichostatin A 100 nM MCF7 0.698 3510 378 657 bromperidol 10 µM MCF7 0.698 2872 379 619 trichostatin A 100 nM HL60 0.698 2375 380 767 LY-294002 10 µM MCF7 0.698 6945 381 513 thioridazine 10 µM MCF7 0.698 1068 382 758 testosterone 12 µM MCF7 0.698 5636 383 744 securinine 18 µM MCF7 0.698 6831 384 618 mebendazole 14 µM HL60 0.697 2338 385 746 thioproperazine 6 µM MCF7 0.697 6265 386 746 spironolactone 10 µM MCF7 0.697 6255 387 729 trichostatin A 100 nM MCF7 0.696 5308 388 502 ionomycin 2 µM MCF7 0.696 979 389 706 trichostatin A 100 nM MCF7 0.696 4954 390 705 trichostatin A 100 nM MCF7 0.696 4388 391 710 metixene 12 µM PC3 0.696 6672 392 677 tribenoside 8 µM MCF7 0.695 3507

12 393 744 diperodon 9 µM MCF7 0.695 6836 394 632 ticlopidine 13 µM MCF7 0.695 1475 395 647 metitepine 8 µM MCF7 0.695 3231 396 703 beta-escin 3 µM PC3 0.694 4544 397 705 terconazole 8 µM MCF7 0.694 4407 398 513 tanespimycin 1 µM MCF7 0.693 1056 399 765 sirolimus 100 nM MCF7 0.693 6967 400 633 trichostatin A 100 nM MCF7 0.693 1535 401 729 cisapride 9 µM MCF7 0.693 5305 402 743 nocodazole 13 µM MCF7 0.693 6793 403 765 troglitazone 10 µM MCF7 0.693 6991 404 46 thioridazine 10 µM MCF7 0.693 417 405 736 trichostatin A 100 nM MCF7 0.693 5441 406 750 fluphenazine 10 µM HL60 0.693 6196 407 707 trichostatin A 100 nM MCF7 0.693 5017 408 619 fenoterol 10 µM HL60 0.692 2378 409 738 rimexolone 11 µM MCF7 0.691 5517 410 513 fluphenazine 10 µM MCF7 0.69 1075 411 694 trichostatin A 100 nM MCF7 0.69 4770 412 708 perphenazine 10 µM MCF7 0.69 5698 413 664 alprostadil 11 µM HL60 0.69 2938 414 738 enilconazole 13 µM MCF7 0.689 5538 415 676 trichostatin A 100 nM MCF7 0.689 7324 416 655 progesterone 13 µM MCF7 0.689 3287 417 602 thioridazine 10 µM HL60 0.689 1171 418 729 hydrocortisone 11 µM MCF7 0.689 5284 419 657 resveratrol 18 µM MCF7 0.689 2865 420 513 tanespimycin 1 µM MCF7 0.689 1044 421 657 Prestwick-559 8 µM MCF7 0.689 2877 422 1082 irinotecan 100 µM MCF7 0.688 7498 423 704 thiostrepton 2 µM PC3 0.687 4563 424 765 nordihydroguaiaretic 1 µM MCF7 0.687 6983 acid 425 633 chlorhexidine 8 µM MCF7 0.687 1525 426 618 trichostatin A 100 nM HL60 0.687 2370 427 747 trifluridine 14 µM MCF7 0.686 7176 428 504 prazosin 10 µM MCF7 0.686 826 429 748 ivermectin 5 µM MCF7 0.686 7206 430 504 quinostatin 10 µM MCF7 0.685 865 431 656 benperidol 10 µM MCF7 0.685 2836 432 610 thioridazine 10 µM PC3 0.685 1905

13 433 602 prochlorperazine 10 µM HL60 0.684 1156 434 752 abamectin 5 µM MCF7 0.684 6081 435 676 zuclopenthixol 9 µM MCF7 0.684 7356 436 636 isoconazole 10 µM MCF7 0.684 2218 437 765 sirolimus 100 nM MCF7 0.684 6981 438 743 berberine 11 µM MCF7 0.683 6791 439 628 chlorpromazine 11 µM PC3 0.683 1822 440 626 valproic acid 1 mM MCF7 0.683 1634 441 504 blebbistatin 17 µM MCF7 0.683 837 442 765 LY-294002 10 µM MCF7 0.682 6995 443 738 proguanil 14 µM MCF7 0.682 5506 444 767 geldanamycin 1 µM MCF7 0.681 6946 445 627 chlorpromazine 11 µM MCF7 0.681 1700 446 1055 0297417-0002B 10 µM MCF7 0.681 6900 447 772 trazodone 10 µM MCF7 0.681 7452 448 506 valproic acid 1 mM MCF7 0.68 989 449 653 ouabain 5 µM MCF7 0.68 2656 450 744 dihydroergotamine 3 µM MCF7 0.679 6840 451 725 nordihydroguaiaretic 1 µM MCF7 0.678 5220 acid 452 735 butoconazole 8 µM MCF7 0.678 5388 453 506 LY-294002 10 µM MCF7 0.678 1016 454 626 LY-294002 10 µM MCF7 0.678 1652 455 636 spironolactone 10 µM MCF7 0.678 2226 456 670 flecainide 8 µM MCF7 0.678 3418 457 602 geldanamycin 1 µM HL60 0.677 1169 458 745 clotrimazole 12 µM MCF7 0.677 6207 459 771 doxepin 13 µM MCF7 0.677 7415 460 67 calmidazolium 5 µM MCF7 0.677 486 461 701 gossypol 8 µM PC3 0.677 4296 462 771 pimethixene 10 µM MCF7 0.676 7426 463 637 trichostatin A 100 nM MCF7 0.676 2268 464 765 tanespimycin 1 µM MCF7 0.676 6966 465 752 hexestrol 15 µM MCF7 0.675 6077 466 655 trichostatin A 100 nM MCF7 0.675 3312 467 754 doxepin 13 µM PC3 0.675 6337 468 660 fluspirilene 8 µM HL60 0.675 3086 469 622 clonidine 15 µM HL60 0.675 1555 470 726 trichostatin A 100 nM MCF7 0.674 5260 471 673 fluvastatin 9 µM MCF7 0.674 3370 472 671 proadifen 10 µM MCF7 0.674 3446

14 473 757 tanespimycin 1 µM MCF7 0.674 5578 474 699 mebendazole 14 µM MCF7 0.674 4694 475 762 triamterene 16 µM PC3 0.674 7307 476 767 15-delta 10 µM MCF7 0.674 6948 prostaglandin J2 477 504 trichostatin A 1 µM MCF7 0.674 873 478 752 trichostatin A 100 nM MCF7 0.674 6085 479 731 disulﬁram 13 µM PC3 0.674 5729 480 729 ﬂuvastatin 9 µM MCF7 0.674 5290 481 670 levonorgestrel 13 µM MCF7 0.673 3406 482 703 chlorcyclizine 12 µM PC3 0.673 4546 483 603 acetylsalicylic acid 100 µM PC3 0.673 1204 484 705 beclometasone 8 µM MCF7 0.673 4403 485 502 5211181 12 µM MCF7 0.673 950 486 746 ellipticine 16 µM MCF7 0.672 6253 487 751 beta-escin 3 µM MCF7 0.672 6050 488 502 tanespimycin 1 µM MCF7 0.672 947 489 727 sirolimus 100 nM PC3 0.672 4445 490 725 tanespimycin 1 µM MCF7 0.672 5223 491 502 geldanamycin 1 µM MCF7 0.672 972 492 771 norethisterone 13 µM MCF7 0.671 7414 493 765 vorinostat 10 µM MCF7 0.671 6980 494 678 cyclopentolate 12 µM MCF7 0.671 3555 495 772 dirithromycin 5 µM MCF7 0.671 7446 496 1021 5707885 50 µM PC3 0.67 6390 497 1054 0297417-0002B 10 µM PC3 0.67 6895 498 729 paclitaxel 5 µM MCF7 0.67 5320 499 633 cyproheptadine 12 µM MCF7 0.67 1521 500 766 trichostatin A 100 nM MCF7 0.669 7005 501 735 azacyclonol 15 µM MCF7 0.669 5398 502 738 bufexamac 18 µM MCF7 0.669 5515 503 633 loxapine 9 µM MCF7 0.669 1516 504 744 acepromazine 9 µM MCF7 0.668 6832 505 506 monorden 100 nM MCF7 0.668 999 506 694 quinisocaine 13 µM MCF7 0.668 4791 507 612 niclosamide 12 µM HL60 0.668 1998 508 743 dipivefrine 10 µM MCF7 0.667 6766 509 772 aminoglutethimide 17 µM MCF7 0.667 7463 510 603 clozapine 10 µM PC3 0.667 1229 511 657 propafenone 11 µM MCF7 0.667 2871 512 725 trichostatin A 1 µM MCF7 0.667 5231

15 513 1089 CP-645525-01 10 µM PC3 0.667 7527 514 506 tanespimycin 1 µM MCF7 0.666 1006 515 626 tanespimycin 1 µM MCF7 0.666 1631 516 673 trichostatin A 100 nM MCF7 0.666 3395 517 662 harmine 16 µM MCF7 0.665 2750 518 750 triﬂuoperazine 10 µM HL60 0.665 6183 519 653 prochlorperazine 7 µM MCF7 0.665 2641 520 772 cortisone 11 µM MCF7 0.665 7458 521 718 trichostatin A 100 nM PC3 0.664 5065 522 654 corticosterone 12 µM MCF7 0.664 3244 523 662 papaverine 11 µM MCF7 0.664 2747 524 506 tanespimycin 1 µM MCF7 0.663 998 525 513 fulvestrant 1 µM MCF7 0.663 1043 526 655 bisacodyl 11 µM MCF7 0.662 3297 527 713 clozapine 12 µM PC3 0.662 4670 528 694 mebhydrolin 5 µM MCF7 0.661 4795 529 707 prasterone 12 µM MCF7 0.661 5019 530 729 profenamine 11 µM MCF7 0.661 5296 531 506 haloperidol 10 µM MCF7 0.661 983 532 726 amiodarone 6 µM MCF7 0.661 5253 533 710 suloctidil 12 µM PC3 0.661 6675 534 725 monorden 100 nM MCF7 0.66 5216 535 648 phenazopyridine 16 µM HL60 0.66 2537 536 762 econazole 9 µM PC3 0.66 7305 537 727 LY-294002 10 µM PC3 0.659 4463 538 732 nicergoline 8 µM PC3 0.659 5775 539 725 LY-294002 10 µM MCF7 0.659 5224 540 699 halcinonide 9 µM MCF7 0.659 4703 541 626 alvespimycin 100 nM MCF7 0.659 1638 542 504 tanespimycin 1 µM MCF7 0.659 831 543 1002 thioridazine 10 µM MCF7 0.658 5916 544 771 indometacin 11 µM MCF7 0.658 7409 545 502 5255229 13 µM MCF7 0.658 949 546 725 fulvestrant 1 µM MCF7 0.658 5202 547 603 haloperidol 10 µM PC3 0.658 1203 548 706 omeprazole 12 µM MCF7 0.658 4951 549 635 tolazamide 13 µM HL60 0.658 2482 550 506 vorinostat 10 µM MCF7 0.657 1000 551 726 dipyridamole 8 µM MCF7 0.657 5252 552 754 trichostatin A 100 nM PC3 0.656 6340 553 737 antimycin A 7 µM MCF7 0.656 5472

16 554 654 primaquine 9 µM MCF7 0.656 3279 555 744 trichostatin A 100 nM MCF7 0.656 6820 556 627 trichostatin A 100 nM MCF7 0.656 1672 557 743 cycloserine 39 µM MCF7 0.655 6782 558 647 ascorbic acid 22 µM MCF7 0.655 3225 559 688 ﬂuvoxamine 9 µM PC3 0.655 3995 560 683 withaferin A 1 µM PC3 0.655 3819 561 627 8-azaguanine 26 µM MCF7 0.655 1670 562 757 vorinostat 10 µM MCF7 0.654 5580 563 757 geldanamycin 1 µM MCF7 0.654 5588 564 738 trichostatin A 100 nM MCF7 0.654 5511 565 707 methapyrilene 13 µM MCF7 0.654 4990 566 706 betahistine 17 µM MCF7 0.653 4956 567 746 hexestrol 15 µM MCF7 0.653 6252 568 626 fulvestrant 1 µM MCF7 0.653 1630 569 729 phenylpropanolamine 21 µM MCF7 0.653 5298 570 706 palmatine 10 µM MCF7 0.653 4957 571 505 sirolimus 100 nM MCF7 0.653 921 572 655 digoxin 5 µM MCF7 0.653 3283 573 632 dicycloverine 12 µM MCF7 0.653 1483 574 661 trichostatin A 100 nM HL60 0.652 3114 575 743 mebeverine 9 µM MCF7 0.652 6795 576 719 trichostatin A 100 nM PC3 0.652 5086 577 735 trichostatin A 100 nM MCF7 0.652 5417 578 765 trichostatin A 1 µM MCF7 0.651 6993 579 767 fulvestrant 1 µM MCF7 0.651 6925 580 748 glibenclamide 8 µM MCF7 0.65 7202 581 711 helveticoside 7 µM MCF7 0.65 3945 582 618 tropicamide 14 µM HL60 0.65 2347 583 708 metyrapone 18 µM MCF7 0.65 5667 584 656 terconazole 8 µM MCF7 0.65 2844 585 506 haloperidol 10 µM MCF7 0.65 1024 586 691 trichostatin A 100 nM MCF7 0.65 4153 587 1086 CP-645525-01 10 µM MCF7 0.649 7515 588 743 trichostatin A 100 nM MCF7 0.649 6784 589 757 LY-294002 10 µM MCF7 0.649 5599 590 504 monorden 100 nM MCF7 0.649 836 591 502 5248896 11 µM MCF7 0.649 955 592 644 conessine 11 µM HL60 0.648 2135 593 690 ﬂuvoxamine 9 µM MCF7 0.648 4114 594 772 noretynodrel 13 µM MCF7 0.648 7471

17 595 670 meclofenoxate 14 µM MCF7 0.648 3405 596 636 dihydroergotamine 3 µM MCF7 0.648 2244 597 603 wortmannin 10 nM PC3 0.647 1243 598 699 dilazep 6 µM MCF7 0.647 4688 599 750 genistein 10 µM HL60 0.647 6194 600 654 digitoxigenin 11 µM MCF7 0.647 3275 601 614 terfenadine 8 µM HL60 0.647 1381 602 644 picrotoxinin 14 µM HL60 0.647 2161 603 730 chlortetracycline 8 µM MCF7 0.647 5360 604 665 piribedil 12 µM HL60 0.646 2951 605 626 fulvestrant 10 nM MCF7 0.646 1663 606 767 trichostatin A 100 nM MCF7 0.646 6932 607 710 clomifene 7 µM PC3 0.646 6648 608 698 tiapride 11 µM PC3 0.646 7362 609 726 butyl hydroxyben- 21 µM MCF7 0.645 5245 zoate 610 764 pimozide 9 µM PC3 0.645 7132 611 772 fenoﬁbrate 11 µM MCF7 0.645 7474 612 676 etofenamate 11 µM MCF7 0.645 7327 613 660 nitrendipine 11 µM HL60 0.644 3087 614 506 sirolimus 100 nM MCF7 0.644 987 615 506 clozapine 10 µM MCF7 0.644 1009 616 627 hydroﬂumethiazide 12 µM MCF7 0.644 1687 617 744 sertaconazole 8 µM MCF7 0.644 6811 618 689 myricetin 13 µM PC3 0.644 4090 619 642 clemizole 11 µM MCF7 0.644 2301 620 502 oxaprozin 300 µM MCF7 0.644 971 621 502 monorden 100 nM MCF7 0.644 953 622 646 fendiline 11 µM MCF7 0.644 3190 623 661 protriptyline 13 µM HL60 0.644 3119 624 752 Prestwick-689 10 µM MCF7 0.643 6076 625 772 risperidone 10 µM MCF7 0.642 7449 626 662 trichostatin A 100 nM MCF7 0.642 2777 627 706 tracazolate 12 µM MCF7 0.641 4964 628 626 trichostatin A 100 nM MCF7 0.641 1637 629 711 trichostatin A 100 nM MCF7 0.64 3979 630 656 pentamidine 7 µM MCF7 0.64 2834 631 633 azathioprine 14 µM MCF7 0.64 1528 632 750 valproic acid 200 µM HL60 0.64 6173 633 744 clobetasol 9 µM MCF7 0.64 6835 634 772 acetazolamide 18 µM MCF7 0.64 7461

18 635 736 budesonide 9 µM MCF7 0.64 5431 636 645 famprofazone 11 µM HL60 0.639 2174 637 732 lidoflazine 8 µM PC3 0.639 5804 638 758 haloperidol 11 µM MCF7 0.639 5638 639 733 piperacetazine 10 µM PC3 0.639 5834 640 754 propafenone 11 µM PC3 0.639 6336 641 726 azathioprine 14 µM MCF7 0.639 5262 642 645 benfotiamine 9 µM HL60 0.639 2177 643 618 tolbutamide 15 µM HL60 0.638 2359 644 95 resveratrol 50 µM MCF7 0.638 595 645 678 verteporfin 3 µM MCF7 0.638 3556 646 750 sirolimus 100 nM HL60 0.638 6201 647 647 colchicine 10 µM MCF7 0.638 3213 648 707 ouabain 5 µM MCF7 0.637 5026 649 758 meclozine 9 µM MCF7 0.637 5607 650 656 cetirizine 9 µM MCF7 0.637 2829 651 664 zardaverine 15 µM HL60 0.637 2926 652 734 trichostatin A 100 nM PC3 0.637 5882 653 506 sirolimus 100 nM MCF7 0.637 1022 654 663 emetine 7 µM MCF7 0.637 2801 655 767 vorinostat 10 µM MCF7 0.637 6939 656 513 sirolimus 100 nM MCF7 0.637 1045 657 653 flupentixol 8 µM MCF7 0.637 2643 658 662 DL-thiorphan 16 µM MCF7 0.637 2752 659 771 difenidol 12 µM MCF7 0.637 7406 660 75 gefitinib 10 µM HL60 0.636 541 661 772 betulin 9 µM MCF7 0.636 7454 662 682 lanatoside C 4 µM PC3 0.636 3771 663 703 alpha-ergocryptine 7 µM PC3 0.636 4552 664 633 ciprofloxacin 11 µM MCF7 0.636 1522 665 764 1,4- 15 µM PC3 0.636 7139 chrysenequinone 666 706 protoveratrine A 5 µM MCF7 0.635 4963 667 670 furaltadone 11 µM MCF7 0.635 3413 668 618 kawain 17 µM HL60 0.635 2337 669 649 ethoxyquin 18 µM HL60 0.635 2559 670 730 digoxin 5 µM MCF7 0.635 5324 671 630 bepridil 10 µM HL60 0.635 1274 672 623 metergoline 10 µM HL60 0.635 1606 673 505 tanespimycin 1 µM MCF7 0.634 916 674 663 seneciphylline 12 µM MCF7 0.634 2797

19 675 644 succinylsulfathiazole 11 µM HL60 0.634 2166 676 772 dexpanthenol 19 µM MCF7 0.634 7455 677 626 sirolimus 100 nM MCF7 0.634 1632 678 628 8-azaguanine 26 µM PC3 0.634 1791 679 656 trichostatin A 100 nM MCF7 0.633 2835 680 695 oxetacaine 9 µM MCF7 0.633 4829 681 758 pentoxyverine 8 µM MCF7 0.633 5610 682 727 sirolimus 100 nM PC3 0.633 4431 683 671 alimemazine 5 µM MCF7 0.633 3478 684 708 eticlopride 11 µM MCF7 0.633 5695 685 699 trichostatin A 100 nM MCF7 0.633 4710 686 762 dosulepin 12 µM PC3 0.632 7284 687 654 ciclosporin 3 µM MCF7 0.632 3267 688 673 monobenzone 20 µM MCF7 0.632 3391 689 741 trichostatin A 100 nM MCF7 0.632 5987 690 662 physostigmine 6 µM MCF7 0.632 2768 691 765 acetylsalicylic acid 100 µM MCF7 0.632 6964 692 650 15-delta 10 µM HL60 0.632 2691 prostaglandin J2 693 644 co-dergocrine mesi- 6 µM HL60 0.632 2136 late 694 648 sulfapyridine 16 µM HL60 0.632 2538 695 626 trichostatin A 1 µM MCF7 0.632 1659 696 741 metrifonate 16 µM MCF7 0.632 5989 697 695 buﬂomedil 12 µM MCF7 0.632 4840 698 663 bicuculline 11 µM MCF7 0.631 2796 699 1049 fulvestrant 1 µM MCF7 0.631 6872 700 513 alvespimycin 100 nM MCF7 0.631 1051 701 640 dihydroergocristine 6 µM HL60 0.631 1745 702 665 Prestwick-1083 9 µM HL60 0.631 2976 703 750 tanespimycin 1 µM HL60 0.631 6166 704 646 clomipramine 11 µM MCF7 0.631 3182 705 513 trichostatin A 100 nM MCF7 0.631 1050 706 642 dilazep 6 µM MCF7 0.631 2294 707 502 5252917 14 µM MCF7 0.631 944 708 626 nordihydroguaiaretic 1 µM MCF7 0.63 1648 acid 709 635 6-azathymine 31 µM HL60 0.63 2466 710 698 monensin 6 µM PC3 0.63 7402 711 732 thioproperazine 6 µM PC3 0.63 5791 712 662 tomatidine 10 µM MCF7 0.63 2746

20 713 687 camptothecin 11 µM MCF7 0.63 3887 714 644 emetine 7 µM HL60 0.63 2145 715 642 griseofulvin 11 µM MCF7 0.63 2293 716 502 prazosin 10 µM MCF7 0.629 942 717 513 sirolimus 100 nM MCF7 0.629 1059 718 771 trazodone 10 µM MCF7 0.629 7410 719 602 tanespimycin 1 µM HL60 0.629 1159 720 729 flucytosine 31 µM MCF7 0.629 5289 721 701 benzamil 11 µM PC3 0.629 4294 722 738 nisoxetine 13 µM MCF7 0.629 5516 723 718 pizotifen 9 µM PC3 0.629 5072 724 663 dydrogesterone 13 µM MCF7 0.628 2811 725 751 Prestwick-674 14 µM MCF7 0.628 6034 726 504 5248896 11 µM MCF7 0.628 838 727 719 mometasone 8 µM PC3 0.627 5116 728 673 profenamine 11 µM MCF7 0.627 3376 729 672 reserpine 7 µM MCF7 0.627 3341 730 632 cinchocaine 12 µM MCF7 0.627 1469 731 735 verapamil 8 µM MCF7 0.627 5387 732 772 tetracaine 13 µM MCF7 0.627 7473 733 502 felodipine 10 µM MCF7 0.627 965 734 715 cyproheptadine 12 µM PC3 0.626 6740 735 664 etilefrine 18 µM HL60 0.626 2930 736 673 equilin 15 µM MCF7 0.626 3377 737 725 alvespimycin 100 nM MCF7 0.626 5210 738 663 hydroxyachillin 14 µM MCF7 0.626 2812 739 670 lithocholic acid 11 µM MCF7 0.626 3433 740 766 hydroflumethiazide 12 µM MCF7 0.626 7019 741 708 trichostatin A 100 nM MCF7 0.626 5693 742 656 betahistine 17 µM MCF7 0.626 2833 743 704 chloropyramine 12 µM PC3 0.626 4589 744 710 amoxapine 13 µM PC3 0.625 6650 745 750 tanespimycin 1 µM HL60 0.625 6185 746 767 sirolimus 100 nM MCF7 0.625 6927 747 1008 trichostatin A 1 µM MCF7 0.625 5945 748 663 retrorsine 11 µM MCF7 0.625 2784 749 629 betazole 27 µM HL60 0.625 1854 750 700 gossypol 8 µM MCF7 0.625 4762 751 663 harman 18 µM MCF7 0.624 2806 752 633 dipyridamole 8 µM MCF7 0.624 1517 753 670 flunixin 8 µM MCF7 0.624 3411

21 754 758 azathioprine 14 µM MCF7 0.624 5627 755 754 remoxipride 10 µM PC3 0.624 6342 756 1032 5155877 10 µM PC3 0.624 6544 757 602 LY-294002 10 µM HL60 0.624 1177 758 671 isoetarine 12 µM MCF7 0.624 3451 759 506 tanespimycin 1 µM MCF7 0.623 986 760 683 beta-escin 3 µM PC3 0.623 3807 761 1043 STOCK1N-35696 15 µM MCF7 0.623 6577 762 629 noretynodrel 13 µM HL60 0.623 1860 763 673 phthalylsulfathiazole 10 µM MCF7 0.623 3371 764 713 menadione 23 µM PC3 0.623 4662 765 628 trichostatin A 100 nM PC3 0.623 1793 766 664 sanguinarine 12 µM HL60 0.623 2927 767 762 homochlorcyclizine 10 µM PC3 0.622 7295 768 748 harmine 16 µM MCF7 0.622 7209 769 708 hycanthone 11 µM MCF7 0.622 5691 770 687 beta-escin 3 µM MCF7 0.622 3890 771 664 trichostatin A 100 nM HL60 0.622 2904 772 754 fenoterol 10 µM PC3 0.622 6331 773 653 procainamide 15 µM MCF7 0.622 2618 774 619 isotretinoin 13 µM HL60 0.622 2407 775 664 pronetalol 15 µM HL60 0.622 2902 776 626 monorden 100 nM MCF7 0.622 1644 777 663 solanine 5 µM MCF7 0.622 2808 778 765 tretinoin 1 µM MCF7 0.622 6971 779 612 thioridazine 10 µM HL60 0.621 1986 780 743 alprenolol 14 µM MCF7 0.621 6789 781 746 mianserin 13 µM MCF7 0.621 6260 782 695 emetine 7 µM MCF7 0.621 4827 783 670 sulfamethoxypyridazine14 µM MCF7 0.621 3409 784 513 tanespimycin 1 µM MCF7 0.621 1064 785 642 kawain 17 µM MCF7 0.621 2299 786 673 ganciclovir 16 µM MCF7 0.621 3368 787 617 tolfenamic acid 15 µM PC3 0.621 2120 788 1029 STOCK1N-35215 10 µM PC3 0.62 6427 789 634 epiandrosterone 14 µM HL60 0.62 2444 790 622 oxytetracycline 8 µM HL60 0.62 1553 791 662 cytisine 21 µM MCF7 0.62 2759 792 673 ethaverine 9 µM MCF7 0.62 3375 793 745 amodiaquine 9 µM MCF7 0.62 6224 794 708 dioxybenzone 16 µM MCF7 0.62 5699

22 795 751 lanatoside C 4 µM MCF7 0.62 6048 796 633 haloperidol 11 µM MCF7 0.62 1539 797 626 valproic acid 50 µM MCF7 0.62 1647 798 720 orphenadrine 13 µM MCF7 0.619 4359 799 713 haloperidol 11 µM PC3 0.619 4678 800 699 nitrofurantoin 17 µM MCF7 0.619 4697 801 635 pentamidine 7 µM HL60 0.619 2473 802 695 salsolidin 16 µM MCF7 0.619 4810 803 663 vitexin 9 µM MCF7 0.619 2810 804 761 trichostatin A 100 nM PC3 0.619 7245 805 746 tretinoin 13 µM MCF7 0.619 6243 806 707 estrone 15 µM MCF7 0.619 4993 807 623 cefoperazone 6 µM HL60 0.618 1627 808 745 sulfametoxydiazine 14 µM MCF7 0.618 6212 809 642 nitrofurantoin 17 µM MCF7 0.618 2303 810 720 withaferin A 1 µM MCF7 0.618 4376 811 730 nilutamide 13 µM MCF7 0.617 5362 812 629 procaine 15 µM HL60 0.617 1838 813 720 beta-escin 3 µM MCF7 0.617 4364 814 656 selegiline 18 µM MCF7 0.617 2826 815 730 ioversol 5 µM MCF7 0.617 5326 816 728 cyproterone 10 µM PC3 0.617 4470 817 765 valproic acid 200 µM MCF7 0.617 6974 818 726 equilin 15 µM MCF7 0.617 5255 819 695 trichostatin A 100 nM MCF7 0.617 4821 820 513 LY-294002 10 µM MCF7 0.617 1065 821 731 trichostatin A 100 nM PC3 0.617 5745 822 758 dipyridamole 8 µM MCF7 0.617 5617 823 741 thalidomide 15 µM MCF7 0.617 5990 824 766 glafenine 10 µM MCF7 0.617 7018 825 626 valproic acid 200 µM MCF7 0.617 1639 826 694 benperidol 10 µM MCF7 0.616 4781 827 766 artemisinin 14 µM MCF7 0.616 7007 828 603 sirolimus 100 nM PC3 0.616 1207 829 647 desipramine 13 µM MCF7 0.616 3212 830 655 metixene 12 µM MCF7 0.616 3313 831 616 tamoxifen 7 µM PC3 0.615 2050 832 690 azacitidine 16 µM MCF7 0.615 4128 833 753 verapamil 8 µM PC3 0.615 6287 834 603 vorinostat 10 µM PC3 0.615 1220 835 730 hesperetin 13 µM MCF7 0.615 5350

23 836 698 dilazep 6 µM PC3 0.615 7364 837 614 dihydroergotamine 3 µM HL60 0.615 1398 838 1082 trichostatin A 1 µM MCF7 0.615 7499 839 757 tretinoin 1 µM MCF7 0.614 5571 840 692 pyrimethamine 16 µM PC3 0.614 4194 841 506 trichostatin A 1 µM MCF7 0.614 1014 842 757 fulvestrant 10 nM MCF7 0.614 5598 843 756 alfaxalone 12 µM MCF7 0.614 6514 844 732 saquinavir 5 µM PC3 0.614 5770 845 636 trichostatin A 100 nM MCF7 0.614 2247 846 623 etoposide 7 µM HL60 0.614 1626 847 757 trifluoperazine 10 µM MCF7 0.613 5584 848 1075 MS-275 10 µM PC3 0.613 7084 849 622 tretinoin 13 µM HL60 0.613 1548 850 677 naftifine 12 µM MCF7 0.613 3536 851 603 LY-294002 10 µM PC3 0.613 1227 852 766 asiaticoside 4 µM MCF7 0.612 7004 853 727 sirolimus 100 nM PC3 0.612 4466 854 657 mesoridazine 7 µM MCF7 0.612 2874 855 653 benfluorex 10 µM MCF7 0.612 2621 856 505 docosahexaenoic 100 µM MCF7 0.612 881 acid ethyl ester 857 727 nordihydroguaiaretic 1 µM PC3 0.612 4447 acid 858 1002 rotenone 1 µM MCF7 0.612 5915 859 1008 rotenone 1 µM MCF7 0.611 5943 860 765 fluphenazine 10 µM MCF7 0.611 6996 861 728 sertaconazole 8 µM PC3 0.611 4475 862 707 etoposide 7 µM MCF7 0.611 5027 863 622 terbutaline 7 µM HL60 0.611 1585 864 642 trimethoprim 14 µM MCF7 0.611 2307 865 654 fusaric acid 22 µM MCF7 0.611 3245 866 750 15-delta 10 µM HL60 0.611 6190 prostaglandin J2 867 1092 semustine 100 µM MCF7 0.611 7540 868 707 methotrexate 9 µM MCF7 0.61 5000 869 642 phenformin 17 µM MCF7 0.61 2312 870 655 cisapride 9 µM MCF7 0.61 3305 871 602 sirolimus 100 nM HL60 0.61 1148 872 706 pyrazinamide 32 µM MCF7 0.61 4962 873 767 LY-294002 10 µM MCF7 0.61 6953

24 874 754 nabumetone 18 µM PC3 0.61 6327 875 766 etodolac 14 µM MCF7 0.61 7006 876 613 bromocriptine 5 µM HL60 0.61 2007 877 715 benﬂuorex 10 µM PC3 0.61 6727 878 754 amitriptyline 13 µM PC3 0.61 6353 879 726 cotinine 23 µM MCF7 0.609 5246 880 752 trioxysalen 18 µM MCF7 0.609 6078 881 743 piperidolate 11 µM MCF7 0.609 6772 882 502 bucladesine 2 µM MCF7 0.609 959 883 752 phenazopyridine 16 µM MCF7 0.609 6100 884 705 dicycloverine 12 µM MCF7 0.609 4405 885 720 rifabutin 5 µM MCF7 0.609 4349 886 623 adenosine phos- 11 µM HL60 0.609 1622 phate 887 670 deferoxamine 6 µM MCF7 0.609 3417 888 632 troleandomycin 5 µM MCF7 0.609 1465 889 749 kaempferol 14 µM HL60 0.609 6157 890 622 spiperone 10 µM HL60 0.608 1559 891 506 valproic acid 200 µM MCF7 0.608 994 892 656 6-azathymine 31 µM MCF7 0.608 2827 893 1066 thapsigargin 100 nM MCF7 0.608 7053 894 757 sirolimus 100 nM MCF7 0.608 5581 895 766 morantel 11 µM MCF7 0.608 7010 896 1065 lomustine 100 µM PC3 0.608 7050 897 766 clorsulon 11 µM MCF7 0.608 7025 898 746 tropine 28 µM MCF7 0.608 6264 899 719 rimexolone 11 µM PC3 0.608 5092 900 502 5182598 25 µM MCF7 0.607 976 901 616 isoconazole 10 µM PC3 0.607 2056 902 506 geldanamycin 1 µM MCF7 0.607 1008 903 636 disulﬁram 13 µM MCF7 0.607 2215 904 627 moxisylyte 13 µM MCF7 0.607 1682 905 647 etoposide 7 µM MCF7 0.607 3241 906 650 prochlorperazine 10 µM HL60 0.607 2675 907 751 isosorbide 17 µM MCF7 0.607 6038 908 706 lactobionic acid 11 µM MCF7 0.607 4950 909 1032 trichostatin A 1 µM PC3 0.607 6546 910 728 oxyphenbutazone 12 µM PC3 0.606 4506 911 737 pizotifen 9 µM MCF7 0.606 5491 912 603 tanespimycin 1 µM PC3 0.606 1226 913 729 apomorphine 6 µM MCF7 0.606 5283

25 914 657 scoulerine 12 µM MCF7 0.606 2891 915 730 zaprinast 15 µM MCF7 0.606 5349 916 748 delsoline 9 µM MCF7 0.605 7212 917 647 maprotiline 13 µM MCF7 0.605 3236 918 743 canrenoic acid 10 µM MCF7 0.605 6783 919 677 lymecycline 7 µM MCF7 0.605 3514 920 731 dizocilpine 12 µM PC3 0.605 5746 921 755 trichostatin A 100 nM MCF7 0.605 6454 922 701 trichostatin A 100 nM PC3 0.605 4302 923 627 nifedipine 12 µM MCF7 0.605 1692 924 632 oxetacaine 9 µM MCF7 0.604 1484 925 710 famotidine 12 µM PC3 0.604 6665 926 707 (-)-MK-801 12 µM MCF7 0.604 5003 927 657 etamivan 18 µM MCF7 0.604 2879 928 746 DL-thiorphan 16 µM MCF7 0.604 6249 929 623 clenbuterol 13 µM HL60 0.604 1613 930 673 propofol 22 µM MCF7 0.604 3386 931 749 verteporﬁn 3 µM HL60 0.604 6133 932 603 sirolimus 100 nM PC3 0.604 1221 933 617 hydrastinine 16 µM PC3 0.604 2119 934 707 methoxsalen 19 µM MCF7 0.604 5007 935 1091 CP-319743 10 µM PC3 0.604 7537 936 627 imipramine 13 µM MCF7 0.604 1685 937 627 carbamazepine 17 µM MCF7 0.604 1683 938 662 pyridoxine 19 µM MCF7 0.603 2751 939 746 trichostatin A 100 nM MCF7 0.603 6276 940 654 trichostatin A 100 nM MCF7 0.603 3243 941 738 parthenolide 16 µM MCF7 0.603 5530 942 637 etofylline 18 µM MCF7 0.603 2256 943 617 trichostatin A 100 nM PC3 0.603 2105 944 748 milrinone 19 µM MCF7 0.602 7210 945 756 alfadolone 10 µM MCF7 0.602 6506 946 688 niclosamide 12 µM PC3 0.602 4018 947 627 procaine 15 µM MCF7 0.602 1674 948 613 dipyridamole 8 µM HL60 0.602 2017 949 678 natamycin 6 µM MCF7 0.602 3548 950 642 metaraminol 9 µM MCF7 0.602 2298 951 767 acetylsalicylic acid 100 µM MCF7 0.602 6924 952 757 valproic acid 1 mM MCF7 0.602 5569 953 651 drofenine 11 µM HL60 0.602 2714 954 711 lanatoside C 4 µM MCF7 0.602 3963

26 955 627 amitriptyline 13 µM MCF7 0.601 1701 956 693 cyclobenzaprine 13 µM PC3 0.601 4252 957 708 epiandrosterone 14 µM MCF7 0.601 5687 958 725 valproic acid 1 mM MCF7 0.601 5206 959 732 ebselen 15 µM PC3 0.601 5778 960 729 loxapine 9 µM MCF7 0.601 5293 961 627 triamterene 16 µM MCF7 0.601 1697 962 771 ﬂavoxate 9 µM MCF7 0.601 7405 963 619 pimethixene 10 µM HL60 0.601 2395 964 692 reserpine 7 µM PC3 0.601 4203 965 708 bromocriptine 5 µM MCF7 0.601 5665 966 730 rolitetracycline 8 µM MCF7 0.601 5331 967 729 estradiol 15 µM MCF7 0.601 5318 968 634 puromycin 7 µM HL60 0.601 2448 969 734 pridinol 10 µM PC3 0.6 5860 970 651 isoetarine 12 µM HL60 0.6 2711 971 741 imipenem 13 µM MCF7 0.6 5997 972 663 xylazine 18 µM MCF7 0.6 2788 973 686 helveticoside 7 µM MCF7 0.6 3851 974 618 salbutamol 17 µM HL60 0.6 2344 975 725 vorinostat 10 µM MCF7 0.6 5217 976 736 molsidomine 17 µM MCF7 0.6 5426 977 610 niclosamide 12 µM PC3 0.6 1916 978 750 clozapine 10 µM HL60 0.599 6188 979 663 gramine 23 µM MCF7 0.599 2799 980 753 paracetamol 26 µM PC3 0.599 6284 981 650 triﬂuoperazine 10 µM HL60 0.599 2684 982 619 diethylcarbamazine 10 µM HL60 0.599 2394 983 615 antimycin A 7 µM HL60 0.599 1414 984 626 rosiglitazone 10 µM MCF7 0.599 1658 985 1069 MG-262 100 nM PC3 0.599 7068 986 719 bufexamac 18 µM PC3 0.599 5090 987 700 fenbufen 16 µM MCF7 0.599 4743 988 678 piperidolate 11 µM MCF7 0.599 3551 989 736 alfaxalone 12 µM MCF7 0.599 5451 990 731 clotrimazole 12 µM PC3 0.598 5726 991 748 diclofenac 13 µM MCF7 0.598 7215 992 1033 5155877 10 µM MCF7 0.598 6549 993 1012 LY-294002 10 µM MCF7 0.598 5965 994 751 pempidine 13 µM MCF7 0.598 6027 995 706 dl-alpha tocopherol 9 µM MCF7 0.598 4961

27 996 756 halofantrine 7 µM MCF7 0.598 6509 997 622 etacrynic acid 13 µM HL60 0.598 1565 998 1080 CP-319743 10 µM MCF7 0.598 7486 999 613 hesperetin 13 µM HL60 0.598 2031 1000 695 procyclidine 12 µM MCF7 0.598 4817 1001 751 halcinonide 9 µM MCF7 0.598 6040 1002 756 scopoletin 21 µM MCF7 0.598 6510 1003 767 nordihydroguaiaretic 1 µM MCF7 0.597 6942 acid 1004 645 Prestwick-685 11 µM HL60 0.597 2188 1005 772 8-azaguanine 26 µM MCF7 0.597 7444 1006 672 chloropyramine 12 µM MCF7 0.596 3350 1007 748 trichostatin A 100 nM MCF7 0.596 7236 1008 698 clemizole 11 µM PC3 0.596 7371 1009 747 natamycin 6 µM MCF7 0.596 7167 1010 646 trichostatin A 100 nM MCF7 0.596 3177 1011 1051 trichostatin A 1 µM MCF7 0.596 6879 1012 622 clomipramine 11 µM HL60 0.596 1566 1013 732 hexestrol 15 µM PC3 0.596 5776 1014 676 naftopidil 9 µM MCF7 0.595 7331 1015 648 metoprolol 6 µM HL60 0.595 2543 1016 616 disulﬁram 13 µM PC3 0.595 2053 1017 663 trimethylcolchicinic 12 µM MCF7 0.595 2802 acid 1018 698 Prestwick-685 11 µM PC3 0.595 7382 1019 642 riluzole 15 µM MCF7 0.595 2295 1020 627 mefenamic acid 17 µM MCF7 0.595 1699 1021 685 levonorgestrel 13 µM MCF7 0.595 3606 1022 727 15-delta 10 µM PC3 0.595 4455 prostaglandin J2 1023 650 tretinoin 1 µM HL60 0.594 2671 1024 504 rottlerin 10 µM MCF7 0.594 825 1025 767 tanespimycin 1 µM MCF7 0.594 6944 1026 619 telenzepine 9 µM HL60 0.594 2388 1027 748 neomycin 4 µM MCF7 0.594 7221 1028 633 amoxapine 13 µM MCF7 0.594 1513 1029 626 LY-294002 10 µM MCF7 0.594 1664 1030 733 proadifen 10 µM PC3 0.594 5807 1031 767 alvespimycin 100 nM MCF7 0.594 6933 1032 670 cefazolin 8 µM MCF7 0.594 3426 1033 665 rimexolone 11 µM HL60 0.593 2955

28 1034 626 wortmannin 10 nM MCF7 0.593 1668 1035 602 LY-294002 10 µM HL60 0.593 1168 1036 617 oxymetazoline 13 µM PC3 0.593 2114 1037 753 nizatidine 12 µM PC3 0.593 6305 1038 729 monobenzone 20 µM MCF7 0.593 5312 1039 635 norcyclobenzaprine 15 µM HL60 0.593 2469 1040 720 diethylstilbestrol 15 µM MCF7 0.593 4369 1041 615 trichostatin A 100 nM HL60 0.593 1421 1042 741 nifedipine 12 µM MCF7 0.593 6006 1043 513 LY-294002 10 µM MCF7 0.593 1074 1044 647 methotrexate 9 µM MCF7 0.593 3214 1045 765 chlorpromazine 1 µM MCF7 0.593 6977 1046 677 rimexolone 11 µM MCF7 0.593 3516 1047 650 tanespimycin 1 µM HL60 0.593 2678 1048 649 ﬂunixin 8 µM HL60 0.593 2552 1049 646 mepacrine 8 µM MCF7 0.593 3179 1050 645 halcinonide 9 µM HL60 0.592 2185 1051 627 epirizole 17 µM MCF7 0.592 1681 1052 513 15-delta 10 µM MCF7 0.592 1069 prostaglandin J2 1053 744 aminophenazone 17 µM MCF7 0.592 6818 1054 626 chlorpromazine 1 µM MCF7 0.592 1642 1055 756 nipecotic acid 31 µM MCF7 0.592 6500 1056 753 chlorpropamide 14 µM PC3 0.592 6291 1057 756 enilconazole 13 µM MCF7 0.592 6518 1058 730 zidovudine 15 µM MCF7 0.592 5333 1059 725 alpha-estradiol 10 nM MCF7 0.592 5207 1060 44 valproic acid 1 mM HL60 0.591 409 1061 744 hydrocotarnine 13 µM MCF7 0.591 6827 1062 622 labetalol 11 µM HL60 0.591 1550 1063 726 phthalylsulfathiazole 10 µM MCF7 0.591 5249 1064 671 pipenzolate bro- 9 µM MCF7 0.591 3460 mide 1065 1090 irinotecan 100 µM MCF7 0.591 7530 1066 707 doxazosin 7 µM MCF7 0.59 4988 1067 670 levomepromazine 9 µM MCF7 0.59 3440 1068 771 ifenprodil 8 µM MCF7 0.59 7404 1069 748 azaperone 12 µM MCF7 0.59 7231 1070 633 hesperetin 13 µM MCF7 0.59 1531 1071 730 caﬀeic acid 22 µM MCF7 0.59 5352 1072 647 hycanthone 11 µM MCF7 0.59 3229

29 1073 626 tretinoin 1 µM MCF7 0.59 1636 1074 707 glipizide 9 µM MCF7 0.589 4991 1075 662 (+)-chelidonine 11 µM MCF7 0.589 2779 1076 706 liothyronine 6 µM MCF7 0.589 4947 1077 617 antimycin A 7 µM PC3 0.589 2098 1078 513 haloperidol 10 µM MCF7 0.589 1041 1079 665 talampicillin 8 µM HL60 0.589 2954 1080 737 ifenprodil 8 µM MCF7 0.589 5463 1081 756 aminocaproic acid 30 µM MCF7 0.589 6501 1082 676 proscillaridin 8 µM MCF7 0.588 7340 1083 744 napelline 11 µM MCF7 0.588 6824 1084 671 corbadrine 22 µM MCF7 0.588 3450 1085 730 mitoxantrone 8 µM MCF7 0.588 5354 1086 735 methotrexate 9 µM MCF7 0.588 5419 1087 633 apomorphine 6 µM MCF7 0.588 1505 1088 655 ﬂuoxetine 12 µM MCF7 0.588 3314 1089 664 letrozole 14 µM HL60 0.588 2916 1090 653 amoxicillin 11 µM MCF7 0.588 2620 1091 713 cephaeline 6 µM PC3 0.588 4651 1092 670 ﬂumetasone 10 µM MCF7 0.588 3410 1093 506 nordihydroguaiaretic 1 µM MCF7 0.588 1003 acid 1094 735 dobutamine 12 µM MCF7 0.588 5386 1095 1073 trichostatin A 1 µM PC3 0.588 7077 1096 748 mepyramine 10 µM MCF7 0.588 7223 1097 622 albendazole 15 µM HL60 0.587 1547 1098 660 tyloxapol 4 µM HL60 0.587 3074 1099 1053 trichostatin A 1 µM MCF7 0.587 6891 1100 747 mifepristone 9 µM MCF7 0.587 7183 1101 655 amphotericin B 4 µM MCF7 0.587 3303 1102 677 penbutolol 6 µM MCF7 0.587 3534 1103 616 mianserin 13 µM PC3 0.587 2068 1104 752 clobetasol 9 µM MCF7 0.587 6095 1105 687 rifabutin 5 µM MCF7 0.587 3873 1106 693 procyclidine 12 µM PC3 0.587 4233 1107 708 ketoconazole 8 µM MCF7 0.586 5685 1108 706 apramycin 7 µM MCF7 0.586 4959 1109 649 medrysone 12 µM HL60 0.586 2544 1110 752 strophanthidin 10 µM MCF7 0.586 6087 1111 713 trichostatin A 100 nM PC3 0.586 4665 1112 718 roxarsone 15 µM PC3 0.586 5051

30 1113 647 trichostatin A 100 nM MCF7 0.586 3227 1114 751 benzamil 11 µM MCF7 0.586 6056 1115 616 canrenoic acid 10 µM PC3 0.586 2065 1116 631 naringenin 15 µM HL60 0.586 1342 1117 602 ﬂuphenazine 10 µM HL60 0.586 1178 1118 677 procarbazine 16 µM MCF7 0.586 3533 1119 694 conessine 11 µM MCF7 0.585 4777 1120 709 miconazole 10 µM PC3 0.585 6615 1121 733 cinchonidine 14 µM PC3 0.585 5833 1122 680 0173570-0000 10 µM PC3 0.585 3690 1123 670 spiramycin 5 µM MCF7 0.585 3419 1124 715 carbachol 22 µM PC3 0.585 6742 1125 628 imipramine 13 µM PC3 0.584 1807 1126 765 LY-294002 10 µM MCF7 0.584 6998 1127 626 acetylsalicylic acid 100 µM MCF7 0.584 1629 1128 772 thiamine 12 µM MCF7 0.584 7479 1129 701 PNU-0230031 10 µM PC3 0.584 4288 1130 730 fusidic acid 7 µM MCF7 0.584 5353 1131 642 tropicamide 14 µM MCF7 0.584 2309 1132 663 boldine 12 µM MCF7 0.584 2804 1133 766 pargyline 20 µM MCF7 0.584 7016 1134 715 trichostatin A 100 nM PC3 0.584 6736 1135 678 piperacetazine 10 µM MCF7 0.584 3574 1136 758 latamoxef 7 µM MCF7 0.584 5609 1137 767 tanespimycin 1 µM MCF7 0.584 6943 1138 618 riluzole 15 µM HL60 0.584 2334 1139 656 tiabendazole 20 µM MCF7 0.584 2840 1140 699 levomepromazine 9 µM MCF7 0.583 4723 1141 734 isoconazole 10 µM PC3 0.583 5857 1142 766 dyclonine 12 µM MCF7 0.583 7022 1143 1030 5707885 50 µM MCF7 0.583 6433 1144 755 butyl hydroxyben- 21 µM MCF7 0.583 6446 zoate 1145 718 antimycin A 7 µM PC3 0.583 5053 1146 730 ethaverine 9 µM MCF7 0.583 5337 1147 662 dacarbazine 22 µM MCF7 0.583 2754 1148 712 eticlopride 11 µM PC3 0.583 4634 1149 744 labetalol 11 µM MCF7 0.583 6809 1150 708 bisacodyl 11 µM MCF7 0.583 5677 1151 111 paclitaxel 100 nM MCF7 0.582 640 1152 627 acetazolamide 18 µM MCF7 0.582 1686

31 1153 677 asiaticoside 4 µM MCF7 0.582 3504 1154 653 trichostatin A 100 nM MCF7 0.582 2639 1155 714 cisapride 9 µM PC3 0.582 6706 1156 734 abamectin 5 µM PC3 0.582 5864 1157 650 thioridazine 10 µM HL60 0.582 2690 1158 730 adenosine phos- 11 µM MCF7 0.582 5359 phate 1159 671 cinoxacin 15 µM MCF7 0.582 3463 1160 647 ketanserin 7 µM MCF7 0.582 3209 1161 728 labetalol 11 µM PC3 0.582 4473 1162 754 ﬂavoxate 9 µM PC3 0.581 6326 1163 743 picotamide 10 µM MCF7 0.581 6787 1164 730 idazoxan 17 µM MCF7 0.581 5347 1165 505 5286656 50 µM MCF7 0.581 889 1166 618 metoclopramide 12 µM HL60 0.581 2353 1167 738 bupivacaine 12 µM MCF7 0.581 5537 1168 645 ethotoin 20 µM HL60 0.581 2196 1169 710 ciclopirox 15 µM PC3 0.581 6677 1170 686 trichostatin A 100 nM MCF7 0.581 3868 1171 753 aminohippuric acid 21 µM PC3 0.581 6294 1172 671 hexylcaine 13 µM MCF7 0.581 3447 1173 766 mesoridazine 7 µM MCF7 0.581 7017 1174 695 nifuroxazide 15 µM MCF7 0.581 4835 1175 710 ﬂuspirilene 8 µM PC3 0.581 6662 1176 734 corbadrine 22 µM PC3 0.58 5854 1177 731 etacrynic acid 13 µM PC3 0.58 5742 1178 635 thiostrepton 2 µM HL60 0.58 2462 1179 749 (-)-isoprenaline 16 µM HL60 0.58 6149 1180 702 helveticoside 7 µM PC3 0.58 4327 1181 659 latamoxef 7 µM HL60 0.579 3028 1182 655 ciclopirox 15 µM MCF7 0.579 3317 1183 735 terguride 12 µM MCF7 0.579 5400 1184 690 trichostatin A 100 nM MCF7 0.579 4112 1185 771 cortisone 11 µM MCF7 0.579 7416 1186 687 PHA-00745360 10 µM MCF7 0.579 3907 1187 504 felodipine 10 µM MCF7 0.579 848 1188 672 trimipramine 10 µM MCF7 0.579 3342 1189 765 monorden 100 nM MCF7 0.579 6979 1190 663 co-dergocrine mesi- 6 µM MCF7 0.579 2793 late 1191 738 resveratrol 18 µM MCF7 0.579 5509 1192 662 hydrocotarnine 13 µM MCF7 0.579 2765

32 1193 698 0173570-0000 10 µM PC3 0.579 7389 1194 747 trichostatin A 100 nM MCF7 0.579 7179 1195 727 trichostatin A 1 µM PC3 0.579 4458 1196 663 sulfabenzamide 14 µM MCF7 0.579 2814 1197 711 phentolamine 13 µM MCF7 0.578 3971 1198 663 sparteine 17 µM MCF7 0.578 2790 1199 743 ramipril 10 µM MCF7 0.578 6792 1200 618 phentolamine 13 µM HL60 0.578 2362 1201 645 pempidine 13 µM HL60 0.578 2172 1202 616 diazoxide 17 µM PC3 0.578 2052 1203 750 wortmannin 10 nM HL60 0.578 6202 1204 627 diprophylline 16 µM MCF7 0.578 1689 1205 603 15-delta 10 µM PC3 0.578 1231 prostaglandin J2 1206 727 wortmannin 10 nM PC3 0.578 4467 1207 505 wortmannin 10 nM MCF7 0.578 911 1208 754 piribedil 12 µM PC3 0.578 6333 1209 676 pancuronium bro- 5 µM MCF7 0.578 7329 mide 1210 677 etomidate 16 µM MCF7 0.578 3519 1211 766 nimesulide 13 µM MCF7 0.577 7024 1212 695 cyclobenzaprine 13 µM MCF7 0.577 4834 1213 664 zuclopenthixol 9 µM HL60 0.577 2936 1214 618 6- 18 µM HL60 0.577 2351 benzylaminopurine 1215 1016 erastin 20 µM MCF7 0.577 6364 1216 680 Prestwick-685 11 µM PC3 0.577 3683 1217 714 profenamine 11 µM PC3 0.577 6697 1218 1094 trichostatin A 1 µM MCF7 0.577 7550 1219 656 tobramycin 9 µM MCF7 0.577 2841 1220 753 dextromethorphan 11 µM PC3 0.577 6300 1221 706 lysergol 16 µM MCF7 0.577 4966 1222 602 monorden 100 nM HL60 0.577 1160 1223 772 chlorzoxazone 24 µM MCF7 0.576 7456 1224 766 mecamylamine 20 µM MCF7 0.576 7023 1225 703 citalopram 1 µM PC3 0.576 4555 1226 747 benzydamine 12 µM MCF7 0.576 7169 1227 654 lumicolchicine 10 µM MCF7 0.576 3254 1228 1043 PHA-00665752 10 µM MCF7 0.576 6578 1229 753 dobutamine 12 µM PC3 0.576 6286 1230 762 nifedipine 12 µM PC3 0.576 7303

33 1231 757 rosiglitazone 10 µM MCF7 0.576 5593 1232 633 paclitaxel 5 µM MCF7 0.576 1542 1233 623 probucol 8 µM HL60 0.575 1608 1234 730 midecamycin 5 µM MCF7 0.575 5345 1235 635 propylthiouracil 23 µM HL60 0.575 2476 1236 646 mifepristone 9 µM MCF7 0.575 3185 1237 655 pirenperone 10 µM MCF7 0.575 3316 1238 1088 daunorubicin 1 µM MCF7 0.575 7525 1239 1012 fulvestrant 1 µM MCF7 0.575 5964 1240 693 oxetacaine 9 µM PC3 0.575 4246 1241 680 0175029-0000 1 µM PC3 0.575 3694 1242 726 clenbuterol 13 µM MCF7 0.575 5266 1243 661 esculetin 22 µM HL60 0.575 3120 1244 642 hydralazine 20 µM MCF7 0.575 2311 1245 646 oxybutynin 10 µM MCF7 0.575 3168 1246 728 dihydroergotamine 3 µM PC3 0.574 4502 1247 755 clioquinol 13 µM MCF7 0.574 6461 1248 718 pivampicillin 9 µM PC3 0.574 5046 1249 767 sirolimus 100 nM MCF7 0.574 6940 1250 678 oxprenolol 13 µM MCF7 0.574 3568 1251 678 ciprofibrate 14 µM MCF7 0.574 3561 1252 762 imipenem 13 µM PC3 0.574 7294 1253 731 amodiaquine 9 µM PC3 0.573 5747 1254 676 etamsylate 15 µM MCF7 0.573 7335 1255 766 chloroquine 8 µM MCF7 0.573 7012 1256 685 flumetasone 10 µM MCF7 0.573 3610 1257 680 0173570-0000 1 µM PC3 0.573 3693 1258 745 ricinine 24 µM MCF7 0.573 6206 1259 743 monocrotaline 12 µM MCF7 0.573 6771 1260 683 flutamide 14 µM PC3 0.573 3803 1261 738 deptropine 8 µM MCF7 0.573 5543 1262 627 triflupromazine 10 µM MCF7 0.573 1691 1263 772 piroxicam 12 µM MCF7 0.572 7445 1264 602 haloperidol 10 µM HL60 0.572 1144 1265 648 fluorometholone 11 µM HL60 0.572 2509 1266 707 hydroxyzine 9 µM MCF7 0.572 5006 1267 681 sulfamethoxypyridazine14 µM PC3 0.572 3711 1268 631 cyanocobalamin 3 µM HL60 0.572 1315 1269 757 acetylsalicylic acid 100 µM MCF7 0.571 5564 1270 615 ornidazole 18 µM HL60 0.571 1425 1271 766 moxisylyte 13 µM MCF7 0.571 7015

34 1272 738 scoulerine 12 µM MCF7 0.571 5536 1273 687 CP-690334-01 10 µM MCF7 0.571 3906 1274 1028 F0447-0125 10 µM MCF7 0.571 6424 1275 747 pyridoxine 19 µM MCF7 0.571 7171 1276 706 benzthiazide 9 µM MCF7 0.571 4952 1277 753 amoxicillin 11 µM PC3 0.571 6285 1278 695 seneciphylline 12 µM MCF7 0.571 4822 1279 686 furaltadone 11 µM MCF7 0.571 3838 1280 699 Prestwick-685 11 µM MCF7 0.571 4705 1281 750 tanespimycin 1 µM HL60 0.571 6184 1282 725 geldanamycin 1 µM MCF7 0.571 5225 1283 711 famprofazone 11 µM MCF7 0.571 3928 1284 1085 daunorubicin 1 µM PC3 0.571 7511 1285 677 S-propranolol 14 µM MCF7 0.571 3523 1286 718 Prestwick-920 14 µM PC3 0.571 5056 1287 602 15-delta 10 µM HL60 0.571 1172 prostaglandin J2 1288 677 torasemide 11 µM MCF7 0.57 3517 1289 623 clofazimine 8 µM HL60 0.57 1624 1290 743 yohimbine 10 µM MCF7 0.57 6777 1291 618 nitrofurantoin 17 µM HL60 0.57 2341 1292 680 trichostatin A 100 nM PC3 0.57 3688 1293 654 piperine 14 µM MCF7 0.57 3263 1294 728 trichostatin A 100 nM PC3 0.57 4483 1295 756 pizotifen 9 µM MCF7 0.57 6513 1296 727 LY-294002 10 µM PC3 0.569 4460 1297 665 S-propranolol 14 µM HL60 0.569 2961 1298 718 homatropine 11 µM PC3 0.569 5058 1299 730 buspirone 9 µM MCF7 0.569 5343 1300 646 cloﬁlium tosylate 8 µM MCF7 0.569 3187 1301 646 guanethidine 13 µM MCF7 0.569 3171 1302 682 trichostatin A 100 nM PC3 0.569 3787 1303 663 glimepiride 8 µM MCF7 0.569 2809 1304 513 LY-294002 10 µM MCF7 0.569 1077 1305 670 sulfadimidine 13 µM MCF7 0.569 3422 1306 670 demeclocycline 8 µM MCF7 0.569 3404 1307 502 ikarugamycin 2 µM MCF7 0.569 974 1308 746 methacholine chlo- 20 µM MCF7 0.569 6248 ride 1309 650 tanespimycin 1 µM HL60 0.569 2666 1310 663 diﬂorasone 8 µM MCF7 0.569 2798

35 1311 704 trichostatin A 100 nM PC3 0.569 4565 1312 771 dyclonine 12 µM MCF7 0.569 7423 1313 700 phenformin 17 µM MCF7 0.568 4747 1314 660 nimodipine 10 µM HL60 0.568 3103 1315 772 esculetin 22 µM MCF7 0.568 7459 1316 746 azlocillin 8 µM MCF7 0.568 6262 1317 732 skimmianine 15 µM PC3 0.568 5766 1318 695 (+/-)-catechin 14 µM MCF7 0.568 4837 1319 698 0175029-0000 1 µM PC3 0.568 7392 1320 698 mebendazole 14 µM PC3 0.567 7370 1321 746 propidium iodide 6 µM MCF7 0.567 6277 1322 642 metoclopramide 12 µM MCF7 0.567 2315 1323 683 trichostatin A 100 nM PC3 0.567 3791 1324 630 ouabain 5 µM HL60 0.567 1302 1325 690 amiloride 13 µM MCF7 0.567 4109 1326 708 domperidone 7 µM MCF7 0.567 5701 1327 694 mestranol 13 µM MCF7 0.567 4792 1328 733 strophanthidin 10 µM PC3 0.567 5826 1329 678 meropenem 10 µM MCF7 0.567 3564 1330 678 azaperone 12 µM MCF7 0.567 3573 1331 660 (-)-MK-801 12 µM HL60 0.567 3081 1332 513 geldanamycin 1 µM MCF7 0.567 1066 1333 753 baclofen 19 µM PC3 0.567 6313 1334 680 clemizole 11 µM PC3 0.566 3672 1335 1090 fulvestrant 1 µM MCF7 0.566 7534 1336 734 vinpocetine 11 µM PC3 0.566 5859 1337 1071 trichostatin A 1 µM PC3 0.566 7073 1338 705 proscillaridin 8 µM MCF7 0.566 4404 1339 700 demeclocycline 8 µM MCF7 0.566 4728 1340 772 Prestwick-981 11 µM MCF7 0.566 7464 1341 618 fenbendazole 13 µM HL60 0.566 2360 1342 708 droperidol 11 µM MCF7 0.566 5690 1343 756 nisoxetine 13 µM MCF7 0.566 6496 1344 756 remoxipride 10 µM MCF7 0.566 6503 1345 662 acepromazine 9 µM MCF7 0.566 2769 1346 695 SR-95531 11 µM MCF7 0.566 4820 1347 756 adrenosterone 13 µM MCF7 0.566 6486 1348 636 nalbuphine 10 µM MCF7 0.566 2225 1349 602 tanespimycin 1 µM HL60 0.566 1147 1350 695 primaquine 9 µM MCF7 0.566 4845 1351 715 ethaverine 9 µM PC3 0.566 6737

36 1352 758 alfuzosin 9 µM MCF7 0.565 5605 1353 629 metrifonate 16 µM HL60 0.565 1839 1354 743 oxedrine 24 µM MCF7 0.565 6798 1355 633 guanabenz 14 µM MCF7 0.565 1544 1356 765 valproic acid 50 µM MCF7 0.565 6982 1357 707 bezaﬁbrate 11 µM MCF7 0.565 4999 1358 1031 5707885 50 µM PC3 0.565 6438 1359 662 berberine 11 µM MCF7 0.565 2770 1360 660 terguride 9 µM HL60 0.565 3096 1361 662 riboﬂavin 11 µM MCF7 0.565 2760 1362 744 benzylpenicillin 11 µM MCF7 0.565 6839 1363 691 cinchocaine 12 µM MCF7 0.564 4149 1364 725 tanespimycin 1 µM MCF7 0.564 5222 1365 633 erythromycin 5 µM MCF7 0.564 1510 1366 707 edrophonium chlo- 20 µM MCF7 0.564 5001 ride 1367 65 LY-294002 10 µM PC3 0.564 461 1368 658 spectinomycin 10 µM HL60 0.564 2987 1369 662 lobeline 11 µM MCF7 0.564 2763 1370 735 dextromethorphan 11 µM MCF7 0.564 5401 1371 725 fulvestrant 10 nM MCF7 0.564 5235 1372 1045 dinoprostone 10 µM MCF7 0.564 6590 1373 678 dexpropranolol 14 µM MCF7 0.564 3553 1374 657 10- 19 µM MCF7 0.564 2893 methoxyharmalan 1375 727 trichostatin A 100 nM PC3 0.564 4436 1376 603 valproic acid 200 µM PC3 0.564 1214 1377 700 sulfamethoxypyridazine14 µM MCF7 0.564 4733 1378 700 prilocaine 16 µM MCF7 0.564 4749 1379 705 sparteine 17 µM MCF7 0.564 4391 1380 611 perphenazine 10 µM PC3 0.564 1956 1381 744 zomepirac 13 µM MCF7 0.564 6815 1382 748 praziquantel 13 µM MCF7 0.564 7228 1383 636 nocodazole 13 µM MCF7 0.563 2239 1384 657 sulfasalazine 10 µM MCF7 0.563 2882 1385 747 isoetarine 12 µM MCF7 0.563 7170 1386 664 methyldopate 15 µM HL60 0.563 2940 1387 729 benserazide 14 µM MCF7 0.563 5322 1388 756 deptropine 8 µM MCF7 0.563 6523 1389 720 santonin 16 µM MCF7 0.563 4353 1390 765 alpha-estradiol 10 nM MCF7 0.563 6970 1391 695 quercetin 12 µM MCF7 0.563 4846

37 1392 751 solasodine 10 µM MCF7 0.563 6025 1393 661 proxymetacaine 12 µM HL60 0.563 3113 1394 702 trichostatin A 100 nM PC3 0.562 4344 1395 757 tanespimycin 1 µM MCF7 0.562 5585 1396 755 idazoxan 17 µM MCF7 0.562 6465 1397 665 levocabastine 9 µM HL60 0.562 2948 1398 766 enalapril 8 µM MCF7 0.562 7026 1399 738 mefenamic acid 17 µM MCF7 0.562 5534 1400 715 desoxycortone 12 µM PC3 0.562 6758 1401 603 valproic acid 50 µM PC3 0.562 1222 1402 670 ﬂuocinonide 8 µM MCF7 0.562 3414 1403 685 Prestwick-664 8 µM MCF7 0.562 3613 1404 689 betulinic acid 9 µM PC3 0.562 4101 1405 683 diethylstilbestrol 15 µM PC3 0.562 3812 1406 694 probenecid 14 µM MCF7 0.562 4771 1407 718 indometacin 11 µM PC3 0.561 5049 1408 617 levamisole 17 µM PC3 0.561 2094 1409 681 benzamil 11 µM PC3 0.561 3738 1410 655 epiandrosterone 14 µM MCF7 0.561 3306 1411 642 nalidixic acid 15 µM MCF7 0.561 2297 1412 670 alpha-ergocryptine 7 µM MCF7 0.561 3434 1413 727 clozapine 10 µM PC3 0.561 4453 1414 637 nifenazone 13 µM MCF7 0.561 2285 1415 761 artemisinin 14 µM PC3 0.561 7247 1416 626 clozapine 10 µM MCF7 0.56 1654 1417 728 aminophenazone 17 µM PC3 0.56 4481 1418 732 trichostatin A 100 nM PC3 0.56 5802 1419 686 dantrolene 12 µM MCF7 0.56 3867 1420 618 proglumide 12 µM HL60 0.56 2363 1421 656 salsolidin 16 µM MCF7 0.56 2824 1422 741 isotretinoin 13 µM MCF7 0.56 6017 1423 619 trazodone 10 µM HL60 0.56 2379 1424 685 medrysone 12 µM MCF7 0.56 3603 1425 1088 CP-645525-01 10 µM MCF7 0.56 7522 1426 1007 LY-294002 10 µM PC3 0.56 5942 1427 757 valproic acid 200 µM MCF7 0.559 5574 1428 659 (+)-isoprenaline 11 µM HL60 0.559 3046 1429 694 galantamine 11 µM MCF7 0.559 4772 1430 687 ethotoin 20 µM MCF7 0.559 3892 1431 727 vorinostat 10 µM PC3 0.559 4444 1432 714 propofol 22 µM PC3 0.559 6707

38 1433 729 hesperidin 7 µM MCF7 0.559 5313 1434 626 haloperidol 10 µM MCF7 0.559 1628 1435 751 promazine 12 µM MCF7 0.559 6028 1436 729 dexibuprofen 19 µM MCF7 0.559 5311 1437 642 salbutamol 17 µM MCF7 0.559 2306 1438 616 nomifensine 11 µM PC3 0.559 2062 1439 678 (-)-isoprenaline 16 µM MCF7 0.559 3571 1440 737 indometacin 11 µM MCF7 0.559 5468 1441 654 lysergol 16 µM MCF7 0.559 3261 1442 670 eucatropine 12 µM MCF7 0.559 3416 1443 647 methyldopa 19 µM MCF7 0.559 3234 1444 714 promethazine 12 µM PC3 0.559 6717 1445 746 lidoflazine 8 µM MCF7 0.559 6278 1446 727 tanespimycin 1 µM PC3 0.558 4430 1447 685 trichostatin A 100 nM MCF7 0.558 3643 1448 719 bupivacaine 12 µM PC3 0.558 5112 1449 623 ketanserin 7 µM HL60 0.558 1593 1450 748 vinpocetine 11 µM MCF7 0.558 7213 1451 750 monorden 100 nM HL60 0.558 6178 1452 745 terbutaline 7 µM MCF7 0.558 6240 1453 502 blebbistatin 17 µM MCF7 0.558 954 1454 649 tinidazole 16 µM HL60 0.558 2568 1455 629 imipramine 13 µM HL60 0.558 1849 1456 1055 scriptaid 10 µM MCF7 0.558 6901 1457 1028 STOCK1N-35215 10 µM MCF7 0.557 6422 1458 677 betulin 9 µM MCF7 0.557 3513 1459 698 nitrofurantoin 17 µM PC3 0.557 7373 1460 719 resveratrol 18 µM PC3 0.557 5084 1461 733 tetrandrine 6 µM PC3 0.557 5821 1462 743 vinburnine 14 µM MCF7 0.557 6802 1463 695 tolazoline 20 µM MCF7 0.557 4844 1464 111 pentamidine 100 µM MCF7 0.557 639 1465 657 triflusal 16 µM MCF7 0.557 2867 1466 635 orciprenaline 8 µM HL60 0.557 2485 1467 725 chlorpromazine 1 µM MCF7 0.557 5214 1468 686 fluocinonide 8 µM MCF7 0.557 3839 1469 1012 PF-00875133-00 10 µM MCF7 0.557 5967 1470 636 dexamethasone 9 µM MCF7 0.557 2242 1471 602 nordihydroguaiaretic 1 µM HL60 0.557 1164 acid 1472 617 chlorzoxazone 24 µM PC3 0.556 2100

39 1473 602 valproic acid 200 µM HL60 0.556 1155 1474 734 ramifenazone 14 µM PC3 0.556 5879 1475 743 propoxycaine 12 µM MCF7 0.556 6803 1476 628 morantel 11 µM PC3 0.556 1798 1477 757 wortmannin 10 nM MCF7 0.556 5603 1478 506 acetylsalicylic acid 100 µM MCF7 0.556 984 1479 685 meclofenoxate 14 µM MCF7 0.556 3605 1480 647 methylergometrine 9 µM MCF7 0.556 3222 1481 632 oxybuprocaine 12 µM MCF7 0.556 1476 1482 670 mephentermine 9 µM MCF7 0.556 3425 1483 703 orphenadrine 13 µM PC3 0.556 4537 1484 743 antazoline 13 µM MCF7 0.555 6775 1485 1052 trichostatin A 1 µM PC3 0.555 6886 1486 689 trichostatin A 100 nM PC3 0.555 4072 1487 680 dilazep 6 µM PC3 0.555 3665 1488 677 ozagrel 15 µM MCF7 0.555 3503 1489 767 LY-294002 100 nM MCF7 0.555 6935 1490 670 fenoprofen 7 µM MCF7 0.555 3412 1491 734 neomycin 4 µM PC3 0.555 5867 1492 665 trichostatin A 100 nM HL60 0.555 2949 1493 504 geldanamycin 1 µM MCF7 0.555 864 1494 752 cefuroxime 9 µM MCF7 0.555 6088 1495 616 nocodazole 13 µM PC3 0.555 2076 1496 615 gemﬁbrozil 16 µM HL60 0.555 1430 1497 513 tanespimycin 1 µM MCF7 0.555 1063 1498 1043 trichostatin A 1 µM MCF7 0.555 6579 1499 692 canavanine 14 µM PC3 0.555 4197 1500 719 gliclazide 12 µM PC3 0.554 5089 1501 720 alpha-ergocryptine 7 µM MCF7 0.554 4374 1502 619 niﬂumic acid 14 µM HL60 0.554 2399 1503 762 proxyphylline 17 µM PC3 0.554 7290 1504 506 valproic acid 500 µM MCF7 0.554 1020 1505 745 alclometasone 8 µM MCF7 0.554 6229 1506 764 dipivefrine 10 µM PC3 0.554 7124 1507 1010 valinomycin 100 nM MCF7 0.554 5957 1508 762 Trolox C 16 µM PC3 0.554 7304 1509 623 methylergometrine 9 µM HL60 0.554 1607 1510 671 securinine 18 µM MCF7 0.553 3470 1511 630 N6- 14 µM HL60 0.553 1271 methyladenosine 1512 700 0179445-0000 10 µM MCF7 0.553 4755

40 1513 738 chrysin 16 µM MCF7 0.553 5505 1514 698 0173570-0000 1 µM PC3 0.553 7391 1515 662 pseudopelletierine 21 µM MCF7 0.553 2766 1516 688 amiloride 13 µM PC3 0.553 3990 1517 772 acetohexamide 12 µM MCF7 0.553 7482 1518 772 etomidate 16 µM MCF7 0.552 7460 1519 707 velnacrine 12 µM MCF7 0.552 4997 1520 750 LY-294002 10 µM HL60 0.552 6186 1521 613 loperamide 8 µM HL60 0.552 2033 1522 719 prednisolone 11 µM PC3 0.552 5101 1523 658 roxithromycin 5 µM HL60 0.552 2992 1524 727 tanespimycin 1 µM PC3 0.552 4450 1525 659 carbachol 22 µM HL60 0.552 3042 1526 656 L-methionine 22 µM MCF7 0.552 2831 sulfoximine 1527 764 Prestwick-1084 16 µM PC3 0.552 7125 1528 754 proxymetacaine 12 µM PC3 0.551 6332 1529 631 ginkgolide A 10 µM HL60 0.551 1324 1530 709 lysergol 16 µM PC3 0.551 6621 1531 738 cyclizine 13 µM MCF7 0.551 5525 1532 1011 tanespimycin 1 µM PC3 0.551 5958 1533 642 mephenesin 22 µM MCF7 0.551 2304 1534 755 dioxybenzone 16 µM MCF7 0.551 6478 1535 744 clonidine 15 µM MCF7 0.551 6814 1536 751 Prestwick-685 11 µM MCF7 0.551 6043 1537 656 tenoxicam 12 µM MCF7 0.551 2860 1538 657 molsidomine 17 µM MCF7 0.551 2862 1539 505 5152487 10 µM MCF7 0.551 896 1540 766 isoxicam 12 µM MCF7 0.551 7028 1541 748 noscapine 10 µM MCF7 0.55 7204 1542 756 proxymetacaine 12 µM MCF7 0.55 6492 1543 671 mevalolactone 31 µM MCF7 0.55 3459 1544 698 trichostatin A 100 nM PC3 0.55 7387 1545 711 ﬂuocinonide 8 µM MCF7 0.55 3933 1546 762 tranylcypromine 24 µM PC3 0.55 7293 1547 754 ranitidine 11 µM PC3 0.55 6324 1548 678 meprylcaine 15 µM MCF7 0.55 3544 1549 686 deferoxamine 6 µM MCF7 0.55 3842 1550 715 digoxin 5 µM PC3 0.55 6724 1551 630 androsterone 14 µM HL60 0.55 1296 1552 648 ricinine 24 µM HL60 0.55 2505

41 1553 698 cefazolin 8 µM PC3 0.549 7385 1554 678 milrinone 19 µM MCF7 0.549 3552 1555 758 digoxigenin 10 µM MCF7 0.549 5640 1556 703 CP-320650-01 10 µM PC3 0.549 4557 1557 662 tetrahydroalstonine 11 µM MCF7 0.549 2748 1558 96 ciclosporin 1 µM MCF7 0.549 602 1559 611 azacyclonol 15 µM PC3 0.549 1937 1560 683 santonin 16 µM PC3 0.549 3795 1561 698 metaraminol 9 µM PC3 0.549 7368 1562 504 Y-27632 3 µM MCF7 0.548 832 1563 714 felodipine 10 µM PC3 0.548 6695 1564 671 vidarabine 15 µM MCF7 0.548 3445 1565 729 primidone 18 µM MCF7 0.548 5323 1566 741 tranylcypromine 24 µM MCF7 0.548 5996 1567 744 epivincamine 11 µM MCF7 0.548 6838 1568 660 butyl hydroxyben- 21 µM HL60 0.548 3069 zoate 1569 726 clozapine 12 µM MCF7 0.548 5265 1570 623 colchicine 10 µM HL60 0.547 1598 1571 648 trichostatin A 100 nM HL60 0.547 2523 1572 651 pipenzolate bro- 9 µM HL60 0.547 2719 mide 1573 771 lisinopril 9 µM MCF7 0.547 7403 1574 678 saquinavir 5 µM MCF7 0.547 3549 1575 692 digitoxigenin 11 µM PC3 0.547 4217 1576 718 minocycline 8 µM PC3 0.547 5077 1577 631 digitoxigenin 11 µM HL60 0.547 1339 1578 772 ioxaglic acid 3 µM MCF7 0.547 7470 1579 699 riluzole 15 µM MCF7 0.547 4689 1580 766 tiratricol 6 µM MCF7 0.546 7011 1581 737 trichostatin A 100 nM MCF7 0.546 5484 1582 756 octopamine 21 µM MCF7 0.546 6491 1583 603 valproic acid 500 µM PC3 0.546 1240 1584 673 capsaicin 13 µM MCF7 0.546 3372 1585 610 miconazole 10 µM PC3 0.546 1896 1586 727 alvespimycin 100 nM PC3 0.546 4437 1587 612 isoxsuprine 12 µM HL60 0.546 1985 1588 745 dizocilpine 12 µM MCF7 0.546 6223 1589 726 lorglumide 8 µM MCF7 0.546 5254 1590 749 benzylpenicillin 11 µM HL60 0.546 6155 1591 700 bromopride 12 µM MCF7 0.546 4741 1592 771 fenoﬁbrate 11 µM MCF7 0.546 7432

42 1593 751 helveticoside 7 µM MCF7 0.546 6047 1594 691 xylazine 18 µM MCF7 0.546 4147 1595 751 sulfachlorpyridazine 14 µM MCF7 0.546 6046 1596 730 N6- 14 µM MCF7 0.546 5332 methyladenosine 1597 700 medrysone 12 µM MCF7 0.546 4727 1598 615 ﬂufenamic acid 14 µM HL60 0.546 1420 1599 647 nicardipine 8 µM MCF7 0.545 3215 1600 726 testosterone 12 µM MCF7 0.545 5271 1601 694 idoxuridine 11 µM MCF7 0.545 4785 1602 642 sulfamethoxazole 16 µM MCF7 0.545 2296 1603 630 chlorprothixene 11 µM HL60 0.545 1272 1604 658 reserpine 7 µM HL60 0.545 3003 1605 681 medrysone 12 µM PC3 0.545 3705 1606 1081 semustine 100 µM PC3 0.545 7492 1607 656 propylthiouracil 23 µM MCF7 0.544 2837 1608 734 mepyramine 10 µM PC3 0.544 5869 1609 719 pyrantel 11 µM PC3 0.544 5088 1610 694 roxithromycin 5 µM MCF7 0.544 4778 1611 736 tribenoside 8 µM MCF7 0.544 5429 1612 727 haloperidol 10 µM PC3 0.544 4468 1613 654 buﬂomedil 12 µM MCF7 0.543 3274 1614 772 atracurium besilate 3 µM MCF7 0.543 7477 1615 678 mephenytoin 18 µM MCF7 0.543 3580 1616 699 monensin 6 µM MCF7 0.543 4726 1617 642 tiapride 11 µM MCF7 0.543 2292 1618 671 sulfanilamide 23 µM MCF7 0.543 3449 1619 750 nordihydroguaiaretic 1 µM HL60 0.543 6182 acid 1620 681 levonorgestrel 13 µM PC3 0.543 3708 1621 623 methyldopa 19 µM HL60 0.543 1619 1622 633 zimeldine 10 µM MCF7 0.543 1512 1623 629 amitriptyline 13 µM HL60 0.543 1865 1624 753 chlorhexidine 8 µM PC3 0.542 6302 1625 657 hydrastine hy- 10 µM MCF7 0.542 2889 drochloride 1626 626 estradiol 100 nM MCF7 0.542 1633 1627 46 chlorpromazine 10 µM MCF7 0.542 419 1628 736 raubasine 10 µM MCF7 0.542 5459 1629 708 procainamide 15 µM MCF7 0.542 5663 1630 1059 trichostatin A 1 µM MCF7 0.542 6910 1631 505 5151277 14 µM MCF7 0.542 903

43 1632 753 trichostatin A 100 nM PC3 0.542 6316 1633 514 trichostatin A 100 nM MCF7 0.542 1112 1634 767 monorden 100 nM MCF7 0.542 6938 1635 735 zoxazolamine 24 µM MCF7 0.542 5390 1636 602 fulvestrant 1 µM HL60 0.542 1146 1637 505 5140203 15 µM MCF7 0.541 908 1638 704 novobiocin 6 µM PC3 0.541 4569 1639 750 valproic acid 500 µM HL60 0.541 6199 1640 748 nomifensine 11 µM MCF7 0.541 7217 1641 683 orphenadrine 13 µM PC3 0.541 3801 1642 725 LY-294002 10 µM MCF7 0.541 5233 1643 617 xylometazoline 14 µM PC3 0.541 2107 1644 765 haloperidol 10 µM MCF7 0.541 6963 1645 735 nicardipine 8 µM MCF7 0.541 5397 1646 698 griseofulvin 11 µM PC3 0.541 7363 1647 634 iohexol 5 µM HL60 0.541 2461 1648 627 sulindac 11 µM MCF7 0.541 1693 1649 730 betamethasone 10 µM MCF7 0.54 5328 1650 671 isopropamide 8 µM MCF7 0.54 3461 iodide 1651 700 trichostatin A 100 nM MCF7 0.54 4768 1652 736 procarbazine 16 µM MCF7 0.54 5452 1653 629 carbamazepine 17 µM HL60 0.54 1847 1654 700 ketoprofen 16 µM MCF7 0.54 4751 1655 1093 semustine 100 µM PC3 0.54 7545 1656 713 dipyridamole 8 µM PC3 0.54 4656 1657 764 trichostatin A 100 nM PC3 0.54 7136 1658 1045 AG-028671 10 µM MCF7 0.54 6587 1659 1065 trichostatin A 1 µM PC3 0.54 7047 1660 650 nordihydroguaiaretic 1 µM HL60 0.54 2683 acid 1661 738 telenzepine 9 µM MCF7 0.539 5521 1662 649 ﬂumetasone 10 µM HL60 0.539 2551 1663 1049 SC-560 10 µM MCF7 0.539 6870 1664 648 hexestrol 15 µM HL60 0.539 2515 1665 756 proxyphylline 17 µM MCF7 0.539 6494 1666 695 piperine 14 µM MCF7 0.539 4830 1667 734 azaperone 12 µM PC3 0.539 5877 1668 718 piracetam 28 µM PC3 0.539 5043 1669 671 ribostamycin 7 µM MCF7 0.539 3444 1670 765 fulvestrant 10 nM MCF7 0.539 6997 1671 755 ﬂorfenicol 11 µM MCF7 0.539 6460

44 1672 682 phentolamine 13 µM PC3 0.539 3779 1673 619 indometacin 11 µM HL60 0.539 2377 1674 671 cefoxitin 9 µM MCF7 0.539 3477 1675 1066 0316684-0000 10 µM MCF7 0.538 7052 1676 676 sitosterol 10 µM MCF7 0.538 7332 1677 658 liothyronine 6 µM HL60 0.538 2984 1678 688 etofenamate 11 µM PC3 0.538 3989 1679 617 ethosuximide 28 µM PC3 0.538 2116 1680 619 doxepin 13 µM HL60 0.538 2384 1681 636 pindolol 16 µM MCF7 0.538 2238 1682 676 meptazinol 15 µM MCF7 0.538 7326 1683 707 megestrol 10 µM MCF7 0.538 5013 1684 713 guanfacine 14 µM PC3 0.538 4660 1685 613 trichostatin A 100 nM HL60 0.538 2035 1686 671 zomepirac 13 µM MCF7 0.538 3454 1687 772 levamisole 17 µM MCF7 0.537 7450 1688 735 prazosin 10 µM MCF7 0.537 5416 1689 738 sulindac 11 µM MCF7 0.537 5528 1690 1064 trichostatin A 1 µM MCF7 0.537 7043 1691 747 kaempferol 14 µM MCF7 0.537 7196 1692 635 terconazole 8 µM HL60 0.537 2484 1693 633 cotinine 23 µM MCF7 0.537 1511 1694 631 bacampicillin 8 µM HL60 0.537 1337 1695 712 epiandrosterone 14 µM PC3 0.537 4626 1696 748 estriol 14 µM MCF7 0.537 7220 1697 647 betaxolol 12 µM MCF7 0.537 3208 1698 653 cefalexin 11 µM MCF7 0.536 2628 1699 753 ampicillin 10 µM PC3 0.536 6307 1700 673 3-acetylcoumarin 21 µM MCF7 0.536 3382 1701 618 clemizole 11 µM HL60 0.536 2339 1702 700 Prestwick-674 14 µM MCF7 0.536 4738 1703 753 aminophylline 10 µM PC3 0.536 6295 1704 630 clebopride 8 µM HL60 0.536 1292 1705 632 idoxuridine 11 µM MCF7 0.536 1480 1706 1030 trichostatin A 1 µM MCF7 0.536 6434 1707 62 prochlorperazine 10 µM MCF7 0.536 455 1708 648 alclometasone 8 µM HL60 0.536 2532 1709 748 pirenzepine 9 µM MCF7 0.536 7226 1710 603 tanespimycin 1 µM PC3 0.536 1225 1711 654 cyclobenzaprine 13 µM MCF7 0.536 3268 1712 710 (+)-isoprenaline 11 µM PC3 0.535 6663

45 1713 754 benzonatate 7 µM PC3 0.535 6334 1714 692 mebhydrolin 5 µM PC3 0.535 4211 1715 730 carbachol 22 µM MCF7 0.535 5342 1716 708 altretamine 19 µM MCF7 0.535 5688 1717 663 protoveratrine A 5 µM MCF7 0.535 2800 1718 687 orphenadrine 13 µM MCF7 0.535 3883 1719 691 co-dergocrine mesi- 6 µM MCF7 0.535 4152 late 1720 765 sirolimus 100 nM MCF7 0.535 7001 1721 671 butacaine 13 µM MCF7 0.535 3469 1722 767 trichostatin A 1 µM MCF7 0.535 6951 1723 632 hexamethonium 10 µM MCF7 0.534 1482 bromide 1724 695 R-atenolol 15 µM MCF7 0.534 4841 1725 762 trichostatin A 100 nM PC3 0.534 7285 1726 1050 trichostatin A 1 µM PC3 0.534 6874 1727 682 ﬂuocinonide 8 µM PC3 0.534 3757 1728 640 resveratrol 18 µM HL60 0.534 1715 1729 632 naphazoline 16 µM MCF7 0.534 1466 1730 1035 5194442 20 µM MCF7 0.534 6558 1731 656 probenecid 14 µM MCF7 0.534 2825 1732 627 metrifonate 16 µM MCF7 0.534 1675 1733 617 methocarbamol 17 µM PC3 0.534 2111 1734 729 amikacin 7 µM MCF7 0.534 5314 1735 615 chlorphenesin 16 µM HL60 0.534 1432 1736 718 lobelanidine 11 µM PC3 0.534 5080 1737 1091 irinotecan 100 µM PC3 0.534 7535 1738 729 urapidil 9 µM MCF7 0.533 5295 1739 603 LY-294002 100 nM PC3 0.533 1216 1740 632 ethambutol 14 µM MCF7 0.533 1481 1741 28 trichostatin A 100 nM MCF7 0.533 331 1742 743 carbinoxamine 10 µM MCF7 0.533 6786 1743 738 phensuximide 21 µM MCF7 0.533 5522 1744 728 diperodon 9 µM PC3 0.533 4498 1745 725 LY-294002 100 nM MCF7 0.533 5213 1746 767 LY-294002 10 µM MCF7 0.533 6956 1747 654 amantadine 10 µM MCF7 0.532 3280 1748 665 quinpirole 16 µM HL60 0.532 2977 1749 681 ﬂumetasone 10 µM PC3 0.532 3712 1750 671 carbinoxamine 10 µM MCF7 0.532 3466 1751 715 pilocarpine 15 µM PC3 0.532 6741 1752 762 meticrane 15 µM PC3 0.532 7282

46 1753 623 dobutamine 12 µM HL60 0.532 1589 1754 747 clindamycin 9 µM MCF7 0.532 7172 1755 506 chlorpromazine 1 µM MCF7 0.532 997 1756 705 paromomycin 6 µM MCF7 0.532 4420 1757 736 tolfenamic acid 15 µM MCF7 0.532 5454 1758 752 sulfamethizole 15 µM MCF7 0.532 6099 1759 757 trichostatin A 1 µM MCF7 0.532 5594 1760 1076 lomustine 100 µM MCF7 0.532 7089 1761 726 3-acetylcoumarin 21 µM MCF7 0.531 5259 1762 645 flunisolide 9 µM HL60 0.531 2168 1763 642 ofloxacin 11 µM MCF7 0.531 2302 1764 734 repaglinide 9 µM PC3 0.531 5862 1765 681 lomefloxacin 10 µM PC3 0.531 3723 1766 1008 monorden 100 nM MCF7 0.531 5947 1767 513 acetylsalicylic acid 100 µM MCF7 0.531 1042 1768 670 piperacillin 7 µM MCF7 0.531 3420 1769 676 tocainide 17 µM MCF7 0.531 7351 1770 513 valproic acid 1 mM MCF7 0.531 1047 1771 502 5279552 22 µM MCF7 0.531 960 1772 751 metamizole sodium 12 µM MCF7 0.531 6030 1773 743 methylprednisolone 11 µM MCF7 0.531 6785 1774 712 zimeldine 10 µM PC3 0.531 4609 1775 771 glafenine 10 µM MCF7 0.531 7418 1776 657 lobelanidine 11 µM MCF7 0.531 2897 1777 750 sirolimus 100 nM HL60 0.531 6180 1778 705 chloropyramine 12 µM MCF7 0.531 4414 1779 615 norfloxacin 13 µM HL60 0.53 1406 1780 658 propantheline bro- 9 µM HL60 0.53 3013 mide 1781 513 troglitazone 10 µM MCF7 0.53 1070 1782 504 ikarugamycin 2 µM MCF7 0.53 866 1783 632 amprolium 13 µM MCF7 0.53 1479 1784 513 tretinoin 1 µM MCF7 0.53 1049 1785 733 trichostatin A 100 nM PC3 0.53 5822 1786 746 sulfamethizole 15 µM MCF7 0.53 6272 1787 718 norethisterone 13 µM PC3 0.53 5055 1788 762 metrifonate 16 µM PC3 0.53 7287 1789 619 fenofibrate 11 µM HL60 0.53 2401 1790 727 geldanamycin 1 µM PC3 0.53 4452 1791 718 ifenprodil 8 µM PC3 0.53 5044 1792 645 fludroxycortide 9 µM HL60 0.53 2184

47 1793 762 ozagrel 15 µM PC3 0.529 7281 1794 1001 AG-013608 10 µM PC3 0.529 5909 1795 693 primaquine 9 µM PC3 0.529 4263 1796 654 levothyroxine 5 µM MCF7 0.529 3249 sodium 1797 680 salbutamol 17 µM PC3 0.529 3677 1798 703 rifabutin 5 µM PC3 0.529 4527 1799 727 tanespimycin 1 µM PC3 0.529 4442 1800 649 demeclocycline 8 µM HL60 0.529 2545 1801 694 pyrimethamine 16 µM MCF7 0.529 4779 1802 698 Prestwick-665 12 µM PC3 0.529 7380 1803 1080 fulvestrant 1 µM MCF7 0.529 7490 1804 756 nomegestrol 11 µM MCF7 0.529 6525 1805 718 niflumic acid 14 µM PC3 0.529 5071 1806 693 simvastatin 10 µM PC3 0.529 4244 1807 712 ketoconazole 8 µM PC3 0.529 4624 1808 646 tretinoin 13 µM MCF7 0.529 3165 1809 702 flunisolide 9 µM PC3 0.529 4303 1810 756 isometheptene 8 µM MCF7 0.529 6524 1811 756 nabumetone 18 µM MCF7 0.529 6487 1812 730 hemicholinium 7 µM MCF7 0.529 5339 1813 710 sulconazole 9 µM PC3 0.528 6652 1814 644 dydrogesterone 13 µM HL60 0.528 2156 1815 616 aminophenazone 17 µM PC3 0.528 2060 1816 761 flunarizine 8 µM PC3 0.528 7252 1817 646 benzydamine 12 µM MCF7 0.528 3169 1818 87 HNMPA-(AM)3 5 µM PC3 0.528 583 1819 718 denatonium ben- 9 µM PC3 0.528 5061 zoate 1820 752 kinetin 19 µM MCF7 0.528 6073 1821 683 parbendazole 16 µM PC3 0.528 3799 1822 1001 valinomycin 100 nM PC3 0.528 5911 1823 753 metolazone 11 µM PC3 0.528 6292 1824 657 raubasine 10 µM MCF7 0.528 2898 1825 709 lovastatin 10 µM PC3 0.528 6633 1826 701 flumetasone 10 µM PC3 0.528 4272 1827 632 amiloride 13 µM MCF7 0.528 1470 1828 767 fulvestrant 10 nM MCF7 0.528 6955 1829 699 glycopyrronium 10 µM MCF7 0.528 4709 bromide 1830 718 allantoin 25 µM PC3 0.527 5052 1831 101 LM-1685 10 µM MCF7 0.527 612

48 1832 746 papaverine 11 µM MCF7 0.527 6245 1833 661 alfaxalone 12 µM HL60 0.527 3135 1834 635 sisomicin 3 µM HL60 0.527 2493 1835 754 iopanoic acid 7 µM PC3 0.527 6348 1836 701 diphenylpyraline 13 µM PC3 0.527 4299 1837 656 omeprazole 12 µM MCF7 0.527 2828 1838 619 cortisone 11 µM HL60 0.527 2385 1839 657 imipenem 13 µM MCF7 0.527 2873 1840 748 bergenin 12 µM MCF7 0.527 7224 1841 647 chlorpropamide 14 µM MCF7 0.526 3210 1842 710 methotrexate 9 µM PC3 0.526 6654 1843 68 ﬂuphenazine 10 µM MCF7 0.526 490 1844 642 phentolamine 13 µM MCF7 0.526 2323 1845 632 diﬂunisal 16 µM MCF7 0.526 1490 1846 662 monocrotaline 12 µM MCF7 0.526 2749 1847 662 isocorydine 12 µM MCF7 0.526 2780 1848 641 1,4- 15 µM HL60 0.526 1773 chrysenequinone 1849 1054 scriptaid 10 µM PC3 0.526 6896 1850 1084 daunorubicin 1 µM MCF7 0.525 7507 1851 631 ciclosporin 3 µM HL60 0.525 1331 1852 725 haloperidol 10 µM MCF7 0.525 5200 1853 706 sulfabenzamide 14 µM MCF7 0.525 4979 1854 42 LY-294002 10 µM ssMCF7 0.525 401 1855 44 sodium phenylbu- 1 mM HL60 0.525 411 tyrate 1856 616 ursolic acid 9 µM PC3 0.525 2067 1857 747 nalbuphine 10 µM MCF7 0.525 7177 1858 656 sisomicin 3 µM MCF7 0.525 2853 1859 751 sulfamerazine 15 µM MCF7 0.525 6036 1860 651 trichostatin A 100 nM HL60 0.525 2721 1861 631 pepstatin 6 µM HL60 0.525 1328 1862 630 naftidrofuryl 8 µM HL60 0.525 1267 1863 636 pirenzepine 9 µM MCF7 0.525 2234 1864 616 nicergoline 8 µM PC3 0.525 2058 1865 772 chlorphenesin 16 µM MCF7 0.525 7472 1866 629 acetazolamide 18 µM HL60 0.525 1850 1867 747 suxibuzone 9 µM MCF7 0.524 7163 1868 746 saquinavir 5 µM MCF7 0.524 6246 1869 631 lysergol 16 µM HL60 0.524 1325 1870 1085 BCB000039 10 µM PC3 0.524 7510 1871 42 sirolimus 100 nM ssMCF7 0.524 402

49 1872 738 prednicarbate 8 µM MCF7 0.524 5544 1873 761 morantel 11 µM PC3 0.524 7250 1874 602 tanespimycin 1 µM HL60 0.524 1167 1875 719 prednicarbate 8 µM PC3 0.524 5119 1876 617 etofylline 18 µM PC3 0.524 2093 1877 685 hydralazine 20 µM MCF7 0.524 3621 1878 617 ranitidine 11 µM PC3 0.524 2088 1879 748 sulfadoxine 13 µM MCF7 0.524 7205 1880 753 methotrexate 9 µM PC3 0.524 6318 1881 655 serotonin 19 µM MCF7 0.523 3311 1882 757 nordihydroguaiaretic 1 µM MCF7 0.523 5583 acid 1883 729 ﬂorfenicol 11 µM MCF7 0.523 5300 1884 758 3-hydroxy-DL- 18 µM MCF7 0.523 5641 kynurenine 1885 745 gallamine triethio- 4 µM MCF7 0.523 6215 dide 1886 616 atropine oxide 12 µM PC3 0.523 2054 1887 648 tetrandrine 6 µM HL60 0.523 2520 1888 654 cefadroxil 11 µM MCF7 0.523 3259 1889 1026 erastin 20 µM MCF7 0.523 6412 1890 644 solanine 5 µM HL60 0.523 2152 1891 762 nipecotic acid 31 µM PC3 0.523 7296 1892 683 chlorambucil 13 µM PC3 0.523 3788 1893 661 ursodeoxycholic 10 µM HL60 0.523 3105 acid 1894 681 Prestwick-674 14 µM PC3 0.523 3716 1895 681 fenbufen 16 µM PC3 0.522 3721 1896 677 levocabastine 9 µM MCF7 0.522 3509 1897 630 benﬂuorex 10 µM HL60 0.522 1266 1898 751 ethotoin 20 µM MCF7 0.522 6052 1899 729 methylergometrine 9 µM MCF7 0.522 5303 1900 766 laudanosine 11 µM MCF7 0.522 7030 1901 767 valproic acid 200 µM MCF7 0.522 6934 1902 513 sirolimus 100 nM MCF7 0.522 1080 1903 616 dihydroergotamine 3 µM PC3 0.522 2081 1904 703 guaifenesin 20 µM PC3 0.522 4549 1905 701 PNU-0230031 1 µM PC3 0.522 4291 1906 612 oxetacaine 9 µM HL60 0.522 1984 1907 756 Prestwick-920 14 µM MCF7 0.522 6497 1908 627 benzonatate 7 µM MCF7 0.522 1679 1909 693 trichostatin A 100 nM PC3 0.522 4237 1910 672 mestranol 13 µM MCF7 0.521 3346

50 1911 661 pirlindole 12 µM HL60 0.521 3140 1912 748 ramifenazone 14 µM MCF7 0.521 7233 1913 613 cyproheptadine 12 µM HL60 0.521 2021 1914 656 phenacetin 22 µM MCF7 0.521 2832 1915 708 colchicine 10 µM MCF7 0.521 5675 1916 771 chenodeoxycholic 10 µM MCF7 0.521 7433 acid 1917 671 sulfametoxydiazine 14 µM MCF7 0.521 3453 1918 743 pyrithyldione 24 µM MCF7 0.521 6801 1919 655 nitrofural 20 µM MCF7 0.521 3320 1920 673 carbachol 22 µM MCF7 0.52 3380 1921 670 sulfadimethoxine 13 µM MCF7 0.52 3441 1922 698 mephenesin 22 µM PC3 0.52 7374 1923 682 spiramycin 5 µM PC3 0.52 3762 1924 45 trichostatin A 100 nM ssMCF7 0.52 413 1925 766 xylometazoline 14 µM MCF7 0.52 7020 1926 751 pramocaine 12 µM MCF7 0.52 6054 1927 677 roxarsone 15 µM MCF7 0.52 3511 1928 602 vorinostat 10 µM HL60 0.52 1161 1929 690 oxybuprocaine 12 µM MCF7 0.52 4115 1930 728 clobetasol 9 µM PC3 0.52 4497 1931 617 flufenamic acid 14 µM PC3 0.52 2104 1932 644 seneciphylline 12 µM HL60 0.52 2140 1933 602 tanespimycin 1 µM HL60 0.52 1166 1934 726 bephenium hydrox- 9 µM MCF7 0.52 5263 ynaphthoate 1935 615 etofylline 18 µM HL60 0.52 1409 1936 747 cinchonidine 14 µM MCF7 0.519 7190 1937 644 palmatine 10 µM HL60 0.519 2138 1938 719 nisoxetine 13 µM PC3 0.519 5091 1939 645 helveticoside 7 µM HL60 0.519 2192 1940 700 levonorgestrel 13 µM MCF7 0.519 4730 1941 749 oxyphenbutazone 12 µM HL60 0.519 6160 1942 754 S-propranolol 14 µM PC3 0.519 6343 1943 642 indapamide 11 µM MCF7 0.519 2322 1944 754 tubocurarine chlo- 5 µM PC3 0.519 6351 ride 1945 615 ethosuximide 28 µM HL60 0.519 1433 1946 743 Prestwick-1084 16 µM MCF7 0.519 6767 1947 718 flufenamic acid 14 µM PC3 0.519 5059 1948 715 fluoxetine 12 µM PC3 0.519 6757 1949 629 sulfacetamide 16 µM HL60 0.518 1859

51 1950 702 phentolamine 13 µM PC3 0.518 4336 1951 692 atovaquone 11 µM PC3 0.518 4201 1952 718 dapsone 16 µM PC3 0.518 5078 1953 765 clozapine 10 µM MCF7 0.518 6988 1954 745 butacaine 13 µM MCF7 0.518 6225 1955 636 chlorphenamine 10 µM MCF7 0.518 2217 1956 748 corbadrine 22 µM MCF7 0.518 7208 1957 772 bacitracin 3 µM MCF7 0.518 7448 1958 698 pentolonium 7 µM PC3 0.518 7375 1959 682 helveticoside 7 µM PC3 0.518 3770 1960 632 levodopa 20 µM MCF7 0.518 1472 1961 685 heliotrine 13 µM MCF7 0.518 3615 1962 757 troglitazone 10 µM MCF7 0.518 5592 1963 744 (-)-isoprenaline 16 µM MCF7 0.518 6833 1964 772 difenidol 12 µM MCF7 0.518 7447 1965 653 clozapine 12 µM MCF7 0.518 2644 1966 612 trichostatin A 100 nM HL60 0.517 1971 1967 752 ramifenazone 14 µM MCF7 0.517 6097 1968 753 nitrendipine 11 µM PC3 0.517 6304 1969 728 stachydrine 22 µM PC3 0.517 4469 1970 644 harmaline 14 µM HL60 0.517 2149 1971 1050 H-89 500 nM PC3 0.517 6873 1972 738 bethanechol 20 µM MCF7 0.517 5539 1973 618 pentolonium 7 µM HL60 0.517 2343 1974 647 phenylpropanolamine 21 µM MCF7 0.517 3217 1975 676 moxonidine 17 µM MCF7 0.517 7343 1976 654 calcium pantothen- 8 µM MCF7 0.517 3248 ate 1977 771 pergolide 10 µM MCF7 0.517 7434 1978 662 diclofenac 13 µM MCF7 0.517 2756 1979 504 5252917 14 µM MCF7 0.517 828 1980 752 napelline 11 µM MCF7 0.517 6084 1981 728 securinine 18 µM PC3 0.517 4493 1982 46 haloperidol 10 µM MCF7 0.517 418 1983 514 cytochalasin B 21 µM MCF7 0.517 1122 1984 728 ampyrone 20 µM PC3 0.517 4507 1985 504 5255229 13 µM MCF7 0.516 833 1986 603 trichostatin A 1 µM PC3 0.516 1234 1987 653 pentoxyverine 8 µM MCF7 0.516 2623 1988 754 budesonide 9 µM PC3 0.516 6330 1989 678 ondansetron 12 µM MCF7 0.516 3575

52 1990 720 tinidazole 16 µM MCF7 0.516 4370 1991 689 solanine 5 µM PC3 0.516 4087 1992 661 remoxipride 10 µM HL60 0.516 3124 1993 623 metitepine 8 µM HL60 0.516 1616 1994 767 wortmannin 10 nM MCF7 0.516 6959 1995 688 azacitidine 16 µM PC3 0.516 4010 1996 754 dimenhydrinate 9 µM PC3 0.516 6352 1997 705 vitexin 9 µM MCF7 0.516 4413 1998 687 2,6- 27 µM MCF7 0.516 3889 dimethylpiperidine 1999 602 sirolimus 100 nM HL60 0.516 1162 2000 743 butirosin 5 µM MCF7 0.516 6779 2001 615 xylometazoline 14 µM HL60 0.516 1423 2002 720 CP-320650-01 10 µM MCF7 0.515 4379 2003 656 etifenin 12 µM MCF7 0.515 2838 2004 708 betaxolol 12 µM MCF7 0.515 5669 2005 502 tretinoin 1 µM MCF7 0.515 966 2006 745 dienestrol 15 µM MCF7 0.515 6208 2007 1027 erastin 20 µM PC3 0.515 6417 2008 736 acemetacin 10 µM MCF7 0.515 5460 2009 28 mercaptopurine 100 µM MCF7 0.515 334 2010 772 methocarbamol 17 µM MCF7 0.515 7467 2011 709 SR-95639A 10 µM PC3 0.515 6632 2012 645 karakoline 11 µM HL60 0.515 2203 2013 630 cefalexin 11 µM HL60 0.514 1273 2014 1002 PF-00562151-00 10 µM MCF7 0.514 5917 2015 753 nicardipine 8 µM PC3 0.514 6297 2016 660 prazosin 10 µM HL60 0.514 3098 2017 766 triprolidine 13 µM MCF7 0.514 7008 2018 1083 trichostatin A 1 µM PC3 0.514 7503 2019 738 prednisolone 11 µM MCF7 0.514 5526 2020 701 0179445-0000 10 µM PC3 0.514 4289 2021 726 clofazimine 8 µM MCF7 0.514 5277 2022 623 sulfafurazole 15 µM HL60 0.514 1603 2023 692 benperidol 10 µM PC3 0.514 4196 2024 644 trichostatin A 100 nM HL60 0.514 2137 2025 756 ribavirin 16 µM MCF7 0.514 6521 2026 636 triamcinolone 10 µM MCF7 0.514 2241 2027 1009 trichostatin A 1 µM PC3 0.514 5950 2028 622 clotrimazole 12 µM HL60 0.514 1549 2029 712 betaxolol 12 µM PC3 0.514 4608

53 2030 632 acebutolol 11 µM MCF7 0.514 1493 2031 749 oxedrine 24 µM HL60 0.513 6156 2032 713 pentoxyverine 8 µM PC3 0.513 4649 2033 708 ritodrine 12 µM MCF7 0.513 5680 2034 746 ondansetron 12 µM MCF7 0.513 6270 2035 737 ceftazidime 6 µM MCF7 0.513 5473 2036 619 norethisterone 13 µM HL60 0.512 2383 2037 686 ﬂudrocortisone 9 µM MCF7 0.512 3866 2038 771 bufexamac 18 µM MCF7 0.512 7413 2039 734 gabapentin 23 µM PC3 0.512 5875 2040 732 mianserin 13 µM PC3 0.512 5786 2041 734 diclofenac 13 µM PC3 0.512 5861 2042 630 anisomycin 15 µM HL60 0.512 1304 2043 630 zoxazolamine 24 µM HL60 0.512 1270 2044 718 imidurea 10 µM PC3 0.512 5062 2045 653 ritodrine 12 µM MCF7 0.512 2635 2046 736 ranitidine 11 µM MCF7 0.512 5425 2047 670 isocarboxazid 17 µM MCF7 0.512 3424 2048 709 acebutolol 11 µM PC3 0.512 6631 2049 651 ebselen 15 µM HL60 0.512 2717 2050 767 valproic acid 1 mM MCF7 0.511 6929 2051 738 adipiodone 4 µM MCF7 0.511 5510 2052 736 nabumetone 18 µM MCF7 0.511 5428 2053 672 tolmetin 13 µM MCF7 0.511 3347 2054 756 pirlindole 12 µM MCF7 0.511 6519 2055 653 naftidrofuryl 8 µM MCF7 0.511 2622 2056 506 rosiglitazone 10 µM MCF7 0.511 1013 2057 738 pyrantel 11 µM MCF7 0.511 5513 2058 1079 colforsin 500 nM PC3 0.511 7104 2059 623 maprotiline 13 µM HL60 0.511 1621 2060 618 dilazep 6 µM HL60 0.511 2333 2061 694 spectinomycin 10 µM MCF7 0.511 4773 2062 654 carbarsone 15 µM MCF7 0.511 3250 2063 653 androsterone 14 µM MCF7 0.51 2650 2064 726 digoxigenin 10 µM MCF7 0.51 5275 2065 642 lomeﬂoxacin 10 µM MCF7 0.51 2310 2066 745 physostigmine 6 µM MCF7 0.51 6226 2067 692 trichostatin A 100 nM PC3 0.51 4184 2068 645 heliotrine 13 µM HL60 0.51 2180 2069 633 moroxydine 19 µM MCF7 0.51 1527 2070 720 Prestwick-1100 9 µM MCF7 0.51 4356

54 2071 1076 fulvestrant 1 µM MCF7 0.51 7091 2072 762 epirizole 17 µM PC3 0.51 7292 2073 689 tolmetin 13 µM PC3 0.51 4088 2074 603 valproic acid 1 mM PC3 0.51 1209 2075 764 cycloserine 39 µM PC3 0.509 7134 2076 710 trichostatin A 100 nM PC3 0.509 6671 2077 627 betazole 27 µM MCF7 0.509 1690 2078 710 thioguanosine 13 µM PC3 0.509 6643 2079 602 chlorpromazine 1 µM HL60 0.509 1158 2080 1033 trichostatin A 1 µM MCF7 0.509 6551 2081 642 pentolonium 7 µM MCF7 0.509 2305 2082 754 procaine 15 µM PC3 0.509 6329 2083 659 profenamine 11 µM HL60 0.509 3038 2084 648 delsoline 9 µM HL60 0.509 2513 2085 686 lanatoside C 4 µM MCF7 0.509 3852 2086 687 guaifenesin 20 µM MCF7 0.509 3897 2087 1066 SB-202190 1 µM MCF7 0.509 7054 2088 650 trichostatin A 1 µM HL60 0.508 2694 2089 615 pentetrazol 29 µM HL60 0.508 1408 2090 682 famprofazone 11 µM PC3 0.508 3753 2091 87 butein 10 µM PC3 0.508 582 2092 653 tacrine 16 µM MCF7 0.508 2633 2093 636 thioproperazine 6 µM MCF7 0.508 2236 2094 617 tranylcypromine 24 µM PC3 0.508 2101 2095 750 tanespimycin 1 µM HL60 0.508 6177 2096 712 capsaicin 13 µM PC3 0.508 4612 2097 758 aciclovir 18 µM MCF7 0.508 5643 2098 642 tolbutamide 15 µM MCF7 0.508 2320 2099 767 chlorpromazine 1 µM MCF7 0.507 6936 2100 692 conessine 11 µM PC3 0.507 4191 2101 680 tiapride 11 µM PC3 0.507 3663 2102 764 oxybutynin 10 µM PC3 0.507 7126 2103 647 zidovudine 15 µM MCF7 0.507 3211 2104 700 etiocholanolone 14 µM MCF7 0.507 4764 2105 6 chlorpropamide 100 µM MCF7 0.507 141 2106 1015 trichostatin A 1 µM PC3 0.507 5981 2107 640 laudanosine 11 µM HL60 0.507 1741 2108 670 thiamazole 35 µM MCF7 0.506 3432 2109 662 demecarium bro- 6 µM MCF7 0.506 2773 mide 2110 629 nifedipine 12 µM HL60 0.506 1856

55 2111 714 puromycin 7 µM PC3 0.506 6711 2112 754 tolfenamic acid 15 µM PC3 0.506 6354 2113 617 thalidomide 15 µM PC3 0.506 2095 2114 672 iocetamic acid 7 µM MCF7 0.506 3361 2115 734 convolamine 12 µM PC3 0.506 5876 2116 659 propofol 22 µM HL60 0.506 3048 2117 731 cicloheximide 14 µM PC3 0.506 5743 2118 629 triamterene 16 µM HL60 0.505 1861 2119 670 tinidazole 16 µM MCF7 0.505 3430 2120 746 mephenytoin 18 µM MCF7 0.505 6275 2121 729 glycocholic acid 9 µM MCF7 0.505 5316 2122 758 guanfacine 14 µM MCF7 0.505 5621 2123 618 flutamide 14 µM HL60 0.505 2358 2124 726 methyldopa 19 µM MCF7 0.505 5272 2125 615 levamisole 17 µM HL60 0.505 1410 2126 710 progesterone 13 µM PC3 0.505 6646 2127 513 vorinostat 10 µM MCF7 0.505 1058 2128 771 aminoglutethimide 17 µM MCF7 0.504 7421 2129 750 alpha-estradiol 10 nM HL60 0.504 6169 2130 756 articaine 12 µM MCF7 0.504 6517 2131 53 trifluoperazine 10 µM MCF7 0.504 421 2132 647 dobutamine 12 µM MCF7 0.504 3206 2133 695 salsolinol 15 µM MCF7 0.504 4816 2134 698 kawain 17 µM PC3 0.504 7369 2135 766 etamivan 18 µM MCF7 0.504 7021 2136 683 Prestwick-1100 9 µM PC3 0.504 3798 2137 615 nimesulide 13 µM HL60 0.504 1428 2138 627 diphenhydramine 14 µM MCF7 0.504 1708 2139 730 (-)-atenolol 15 µM MCF7 0.504 5325 2140 752 fluorocurarine 12 µM MCF7 0.504 6083 2141 733 benzydamine 12 µM PC3 0.504 5811 2142 681 phenformin 17 µM PC3 0.504 3725 2143 702 citiolone 25 µM PC3 0.503 4311 2144 690 ginkgolide A 10 µM MCF7 0.503 4121 2145 616 chlorphenamine 10 µM PC3 0.503 2055 2146 622 methylprednisolone 11 µM HL60 0.503 1567 2147 708 capsaicin 13 µM MCF7 0.503 5673 2148 685 PNU-0230031 10 µM MCF7 0.503 3629 2149 670 bendroflumethiazide 9 µM MCF7 0.503 3415 2150 1014 trichostatin A 1 µM MCF7 0.503 5976 2151 757 alvespimycin 100 nM MCF7 0.503 5573

56 2152 708 Prestwick-860 35 µM MCF7 0.502 5679 2153 603 genistein 10 µM PC3 0.502 1235 2154 619 dimenhydrinate 9 µM HL60 0.502 2400 2155 680 metaraminol 9 µM PC3 0.502 3669 2156 630 dextromethorphan 11 µM HL60 0.502 1281 2157 640 parthenolide 16 µM HL60 0.502 1736 2158 710 methoxsalen 19 µM PC3 0.502 6661 2159 1073 MG-262 100 nM PC3 0.502 7079 2160 636 isoniazid 29 µM MCF7 0.502 2246 2161 732 bupropion 14 µM PC3 0.502 5782 2162 753 pralidoxime 23 µM PC3 0.502 6283 2163 692 minoxidil 19 µM PC3 0.502 4216 2164 718 hydrastinine 16 µM PC3 0.502 5075 2165 738 gliclazide 12 µM MCF7 0.501 5514 2166 628 naproxen 17 µM PC3 0.501 1828 2167 1093 CP-944629 10 µM PC3 0.501 7549 2168 681 0179445-0000 10 µM PC3 0.501 3733 2169 751 betonicine 25 µM MCF7 0.501 6063 2170 746 quinidine 11 µM MCF7 0.501 6267 2171 678 cycloserine 39 µM MCF7 0.501 3562 2172 1080 semustine 100 µM MCF7 0.501 7487 2173 636 acenocoumarol 11 µM MCF7 0.5 2240 2174 628 diprophylline 16 µM PC3 0.5 1811 2175 736 tubocurarine chlo- 5 µM MCF7 0.5 5449 ride 2176 654 mebhydrolin 5 µM MCF7 0.5 3269 2177 678 Prestwick-1085 15 µM MCF7 0.5 3554 2178 1079 6-bromoindirubin- 500 nM PC3 0.5 7106 3’-oxime 2179 728 clidinium bromide 9 µM PC3 0.5 4499 2180 633 chlortetracycline 8 µM MCF7 0.5 1541 2181 765 LY-294002 100 nM MCF7 0.5 6976 2182 513 wortmannin 10 nM MCF7 0.5 1081 2183 750 troglitazone 10 µM HL60 0.5 6191 2184 708 N-acetyl-L-leucine 23 µM MCF7 0.5 5683 2185 504 5182598 25 µM MCF7 0.5 868 2186 632 diphemanil metil- 10 µM MCF7 0.499 1494 sulfate 2187 615 scopolamine N- 10 µM HL60 0.499 1415 oxide 2188 686 promazine 12 µM MCF7 0.499 3833 2189 712 trichostatin A 100 nM PC3 0.499 4632 2190 663 gelsemine 12 µM MCF7 0.499 2817

57 2191 628 amitriptyline 13 µM PC3 0.499 1823 2192 689 tiaprofenic acid 15 µM PC3 0.499 4091 2193 689 levothyroxine 5 µM PC3 0.499 4069 sodium 2194 635 quercetin 12 µM HL60 0.499 2499 2195 691 ticlopidine 13 µM MCF7 0.499 4155 2196 700 diphenylpyraline 13 µM MCF7 0.499 4765 2197 710 clorgiline 13 µM PC3 0.499 6659 2198 698 ﬂudroxycortide 9 µM PC3 0.499 7378 2199 762 isotretinoin 13 µM PC3 0.499 7315 2200 707 famotidine 12 µM MCF7 0.498 5011 2201 745 dihydrostreptomycin 3 µM MCF7 0.498 6228 2202 660 tonzonium bromide 7 µM HL60 0.498 3080 2203 677 phensuximide 21 µM MCF7 0.498 3521 2204 1049 PF-00562151-00 10 µM MCF7 0.498 6868 2205 628 procaine 15 µM PC3 0.498 1796 2206 602 valproic acid 1 mM HL60 0.498 1150 2207 633 dehydrocholic acid 10 µM MCF7 0.498 1523 2208 645 isosorbide 17 µM HL60 0.498 2183 2209 649 isocarboxazid 17 µM HL60 0.498 2562 2210 627 sulfacetamide 16 µM MCF7 0.497 1695 2211 636 canrenoic acid 10 µM MCF7 0.497 2228 2212 745 meprylcaine 15 µM MCF7 0.497 6204 2213 731 tetracycline 8 µM PC3 0.497 5757 2214 613 amoxapine 13 µM HL60 0.497 2013 2215 715 propranolol 14 µM PC3 0.497 6759 2216 766 disopyramide 12 µM MCF7 0.497 7035 2217 694 pepstatin 6 µM MCF7 0.497 4790 2218 751 chlorcyclizine 12 µM MCF7 0.497 6053 2219 504 5211181 12 µM MCF7 0.497 834 2220 737 niﬂumic acid 14 µM MCF7 0.497 5490 2221 748 pridinol 10 µM MCF7 0.496 7214 2222 614 astemizole 9 µM HL60 0.496 1365 2223 677 proguanil 14 µM MCF7 0.496 3505 2224 748 repaglinide 9 µM MCF7 0.496 7216 2225 627 sulfaphenazole 13 µM MCF7 0.496 1673 2226 747 triamcinolone 10 µM MCF7 0.496 7192 2227 738 oxolinic acid 15 µM MCF7 0.496 5519 2228 673 esculin 12 µM MCF7 0.496 3390 2229 709 trichostatin A 100 nM PC3 0.496 6609 2230 746 cinoxacin 15 µM MCF7 0.496 6257

58 2231 749 cyproterone 10 µM HL60 0.496 6124 2232 622 pimozide 9 µM HL60 0.495 1562 2233 703 ethotoin 20 µM PC3 0.495 4545 2234 712 naringin 7 µM PC3 0.495 4605 2235 686 famprofazone 11 µM MCF7 0.495 3834 2236 602 LY-294002 10 µM HL60 0.495 1180 2237 730 oxantel 7 µM MCF7 0.495 5338 2238 654 brompheniramine 9 µM MCF7 0.495 3271 2239 655 biotin 16 µM MCF7 0.495 3289 2240 704 pentamidine 7 µM PC3 0.495 4573 2241 617 gemﬁbrozil 16 µM PC3 0.495 2113 2242 628 acetohexamide 12 µM PC3 0.495 1829 2243 513 chlorpromazine 1 µM MCF7 0.495 1055 2244 764 ronidazole 20 µM PC3 0.494 7131 2245 754 sulfacetamide 16 µM PC3 0.494 6349 2246 708 chlormezanone 15 µM MCF7 0.494 5697 2247 758 pirenperone 10 µM MCF7 0.494 5639 2248 692 hydroxyachillin 14 µM PC3 0.494 4213 2249 1057 STOCK1N-28457 20 µM MCF7 0.494 6906 2250 698 halcinonide 9 µM PC3 0.494 7379 2251 713 naloxone 11 µM PC3 0.494 4645 2252 731 sulfametoxydiazine 14 µM PC3 0.494 5732 2253 632 pyrimethamine 16 µM MCF7 0.494 1474 2254 750 LY-294002 10 µM HL60 0.494 6198 2255 747 ursolic acid 9 µM MCF7 0.494 7181 2256 772 trapidil 19 µM MCF7 0.494 7475 2257 691 corticosterone 12 µM MCF7 0.494 4145 2258 612 cimetidine 16 µM HL60 0.494 1964 2259 755 promethazine 12 µM MCF7 0.494 6477 2260 637 meclofenamic acid 12 µM MCF7 0.494 2291 2261 735 ascorbic acid 22 µM MCF7 0.494 5407 2262 1013 LY-294002 10 µM PC3 0.494 5970 2263 1074 pioglitazone 10 µM MCF7 0.493 7083 2264 1006 LY-294002 10 µM MCF7 0.493 5937 2265 735 amphotericin B 4 µM MCF7 0.493 5404 2266 635 phenacetin 22 µM HL60 0.493 2471 2267 616 clindamycin 9 µM PC3 0.493 2057 2268 107 resveratrol 50 µM MCF7 0.493 622 2269 514 monensin 11 µM MCF7 0.493 1105 2270 738 carbamazepine 17 µM MCF7 0.493 5518 2271 727 troglitazone 10 µM PC3 0.493 4456

59 2272 646 oxytetracycline 8 µM MCF7 0.493 3170 2273 734 leflunomide 15 µM PC3 0.493 5884 2274 744 iopromide 5 µM MCF7 0.493 6842 2275 738 flucloxacillin 8 µM MCF7 0.493 5527 2276 1066 colforsin 500 nM MCF7 0.493 7055 2277 761 etodolac 14 µM PC3 0.492 7246 2278 743 acetylsalicylsalicylic 13 µM MCF7 0.492 6778 acid 2279 693 zuclopenthixol 9 µM PC3 0.492 4261 2280 628 sulfacetamide 16 µM PC3 0.492 1817 2281 617 nimesulide 13 µM PC3 0.492 2112 2282 730 benfluorex 10 µM MCF7 0.492 5327 2283 615 tiratricol 6 µM HL60 0.492 1412 2284 1029 0225151-0000 10 µM PC3 0.492 6426 2285 637 pentetrazol 29 µM MCF7 0.492 2255 2286 612 acebutolol 11 µM HL60 0.492 1993 2287 703 tinidazole 16 µM PC3 0.492 4548 2288 762 ketorolac 11 µM PC3 0.492 7286 2289 718 perhexiline 10 µM PC3 0.491 5081 2290 762 lymecycline 7 µM PC3 0.491 7291 2291 752 tetryzoline 17 µM MCF7 0.491 6069 2292 619 nortriptyline 13 µM HL60 0.491 2391 2293 678 cyproterone 10 µM MCF7 0.491 3545 2294 653 coralyne 10 µM MCF7 0.491 2652 2295 1092 CP-944629 10 µM MCF7 0.491 7544 2296 746 methanthelinium 10 µM MCF7 0.491 6254 bromide 2297 747 hecogenin 9 µM MCF7 0.491 7175 2298 618 dantrolene 12 µM HL60 0.491 2369 2299 754 sulfasalazine 10 µM PC3 0.491 6346 2300 678 ramipril 10 µM MCF7 0.49 3572 2301 689 cinchocaine 12 µM PC3 0.49 4068 2302 615 aztreonam 9 µM HL60 0.49 1435 2303 629 sulindac 11 µM HL60 0.49 1857 2304 692 isoxsuprine 12 µM PC3 0.49 4205 2305 615 meclofenamic acid 12 µM HL60 0.49 1445 2306 688 ginkgolide A 10 µM PC3 0.49 4002 2307 745 cicloheximide 14 µM MCF7 0.49 6220 2308 670 dicoumarol 12 µM MCF7 0.49 3423 2309 699 ofloxacin 11 µM MCF7 0.49 4696 2310 650 chlorpromazine 1 µM HL60 0.49 2677 2311 714 glycocholic acid 9 µM PC3 0.49 6716

60 2312 603 alpha-estradiol 10 nM PC3 0.49 1210 2313 682 sulfachlorpyridazine 14 µM PC3 0.49 3769 2314 1046 5194442 20 µM PC3 0.49 6594 2315 622 mepacrine 8 µM HL60 0.49 1563 2316 738 ﬂumequine 15 µM MCF7 0.49 5529 2317 645 eldeline 8 µM HL60 0.49 2171 2318 710 hydroxyzine 9 µM PC3 0.489 6660 2319 753 zoxazolamine 24 µM PC3 0.489 6290 2320 746 methazolamide 17 µM MCF7 0.489 6268 2321 642 dantrolene 12 µM MCF7 0.489 2329 2322 699 0173570-0000 10 µM MCF7 0.489 4712 2323 649 eucatropine 12 µM HL60 0.489 2556 2324 619 dropropizine 17 µM HL60 0.489 2398 2325 715 lynestrenol 14 µM PC3 0.489 6756 2326 734 oxprenolol 13 µM PC3 0.489 5871 2327 736 remoxipride 10 µM MCF7 0.488 5443 2328 694 atovaquone 11 µM MCF7 0.488 4786 2329 615 tolfenamic acid 15 µM HL60 0.488 1437 2330 713 meclozine 9 µM PC3 0.488 4646 2331 694 isoxsuprine 12 µM MCF7 0.488 4789 2332 632 doxylamine 10 µM MCF7 0.488 1473 2333 602 trichostatin A 1 µM HL60 0.488 1175 2334 709 tracazolate 12 µM PC3 0.488 6619 2335 732 tretinoin 13 µM PC3 0.488 5767 2336 737 adrenosterone 13 µM MCF7 0.487 5464 2337 762 fenspiride 13 µM PC3 0.487 7298 2338 695 succinylsulfathiazole 11 µM MCF7 0.487 4847 2339 514 tyrphostin AG-825 25 µM MCF7 0.487 1114 2340 745 etanidazole 19 µM MCF7 0.487 6211 2341 615 hyoscyamine 14 µM HL60 0.487 1424 2342 715 erythromycin 5 µM PC3 0.487 6729 2343 612 dicycloverine 12 µM HL60 0.487 1983 2344 754 oxymetazoline 13 µM PC3 0.487 6350 2345 617 hyoscyamine 14 µM PC3 0.487 2108 2346 738 aztreonam 9 µM MCF7 0.487 5535 2347 631 amantadine 10 µM HL60 0.487 1344 2348 647 clenbuterol 13 µM MCF7 0.487 3228 2349 618 phenformin 17 µM HL60 0.487 2350 2350 676 nifurtimox 14 µM MCF7 0.487 7328 2351 631 carcinine 22 µM HL60 0.487 1305 2352 618 ketoprofen 16 µM HL60 0.486 2354

61 2353 729 moroxydine 19 µM MCF7 0.486 5304 2354 705 levodopa 20 µM MCF7 0.486 4394 2355 617 scopolamine N- 10 µM PC3 0.486 2099 oxide 2356 618 trimethoprim 14 µM HL60 0.485 2345 2357 752 cefalotin 10 µM MCF7 0.485 6079 2358 762 pivmecillinam 8 µM PC3 0.485 7312 2359 640 tubocurarine chlo- 5 µM HL60 0.485 1738 ride 2360 714 monobenzone 20 µM PC3 0.485 6713 2361 706 harpagoside 8 µM MCF7 0.485 4981 2362 713 ﬂurbiprofen 16 µM PC3 0.485 4674 2363 660 promethazine 12 µM HL60 0.485 3100 2364 671 methacholine chlo- 20 µM MCF7 0.485 3452 ride 2365 615 pentoxifylline 14 µM HL60 0.485 1444 2366 615 alverine 8 µM HL60 0.485 1426 2367 682 deferoxamine 6 µM PC3 0.485 3760 2368 710 bretylium tosilate 10 µM PC3 0.485 6674 2369 766 levocabastine 9 µM MCF7 0.485 7009 2370 629 hydroﬂumethiazide 12 µM HL60 0.485 1851 2371 1092 BCB000038 10 µM MCF7 0.484 7542 2372 1002 tanespimycin 1 µM MCF7 0.484 5914 2373 694 epitiostanol 13 µM MCF7 0.484 4788 2374 693 fosfosal 18 µM PC3 0.484 4239 2375 692 mestranol 13 µM PC3 0.484 4208 2376 650 valproic acid 1 mM HL60 0.484 2669 2377 42 wortmannin 10 nM ssMCF7 0.484 404 2378 753 amphotericin B 4 µM PC3 0.484 6303 2379 710 doxazosin 7 µM PC3 0.484 6642 2380 746 skimmianine 15 µM MCF7 0.484 6242 2381 1079 trichostatin A 1 µM PC3 0.484 7105 2382 506 tretinoin 1 µM MCF7 0.484 991 2383 1029 F0447-0125 10 µM PC3 0.484 6429 2384 710 luteolin 14 µM PC3 0.484 6658 2385 735 chlorpropamide 14 µM MCF7 0.483 5391 2386 734 nadide 6 µM PC3 0.483 5873 2387 743 aconitine 6 µM MCF7 0.483 6797 2388 75 1,5-isoquinolinediol 100 µM HL60 0.483 543 2389 35 LY-294002 10 µM HL60 0.483 361 2390 506 valproic acid 50 µM MCF7 0.483 1002 2391 708 tyloxapol 4 µM MCF7 0.483 5672

62 2392 744 riboﬂavin 11 µM MCF7 0.483 6822 2393 713 sulfafurazole 15 µM PC3 0.483 4661 2394 732 quinidine 11 µM PC3 0.483 5793 2395 750 haloperidol 10 µM HL60 0.483 6203 2396 614 nicergoline 8 µM HL60 0.482 1374 2397 709 lactobionic acid 11 µM PC3 0.482 6605 2398 706 Prestwick-857 12 µM MCF7 0.482 4980 2399 617 alverine 8 µM PC3 0.482 2110 2400 637 ethosuximide 28 µM MCF7 0.482 2280 2401 628 moxisylyte 13 µM PC3 0.482 1804 2402 687 parbendazole 16 µM MCF7 0.482 3881 2403 746 Prestwick-1085 15 µM MCF7 0.482 6250 2404 738 hyoscyamine 14 µM MCF7 0.482 5524 2405 745 trioxysalen 18 µM MCF7 0.481 6216 2406 756 ﬂucloxacillin 8 µM MCF7 0.481 6507 2407 1003 tanespimycin 1 µM PC3 0.481 5919 2408 749 azaperone 12 µM HL60 0.481 6151 2409 743 midodrine 14 µM MCF7 0.481 6804 2410 56 sodium phenylbu- 1 mM PC3 0.481 434 tyrate 2411 618 phenelzine 17 µM HL60 0.481 2357 2412 616 picotamide 10 µM PC3 0.481 2070 2413 743 sulfaquinoxaline 12 µM MCF7 0.481 6788 2414 614 pirenzepine 9 µM HL60 0.481 1388 2415 1000 valinomycin 100 nM MCF7 0.481 5906 2416 1005 sirolimus 100 nM PC3 0.481 5932 2417 694 calcium pantothen- 8 µM MCF7 0.48 4775 ate 2418 617 chlorphenesin 16 µM PC3 0.48 2115 2419 612 amprolium 13 µM HL60 0.48 1979 2420 713 azathioprine 14 µM PC3 0.48 4667 2421 630 tacrine 16 µM HL60 0.48 1278 2422 647 sulfafurazole 15 µM MCF7 0.48 3218 2423 749 thiethylperazine 6 µM HL60 0.48 6154 2424 1085 CP-863187 10 µM PC3 0.48 7512 2425 727 fulvestrant 1 µM PC3 0.48 4429 2426 712 ritodrine 12 µM PC3 0.48 4619 2427 693 dydrogesterone 13 µM PC3 0.48 4254 2428 746 dorzolamide 11 µM MCF7 0.48 6259 2429 641 syrosingopine 6 µM HL60 0.48 1761 2430 737 trimetazidine 12 µM MCF7 0.48 5479 2431 678 oxedrine 24 µM MCF7 0.48 3578

63 2432 641 papaverine 11 µM HL60 0.479 1755 2433 506 alpha-estradiol 10 nM MCF7 0.479 990 2434 502 depudecin 1 µM MCF7 0.479 982 2435 730 cefotiam 7 µM MCF7 0.479 5361 2436 720 tolbutamide 15 µM MCF7 0.479 4362 2437 660 bephenium hydrox- 9 µM HL60 0.479 3089 ynaphthoate 2438 680 mephenesin 22 µM PC3 0.479 3675 2439 671 methazolamide 17 µM MCF7 0.479 3474 2440 761 talampicillin 8 µM PC3 0.479 7254 2441 709 meclocycline 6 µM PC3 0.479 6637 2442 636 tetracycline 8 µM MCF7 0.479 2243 2443 714 apomorphine 6 µM PC3 0.479 6683 2444 1061 trichostatin A 1 µM MCF7 0.479 6916 2445 753 coralyne 10 µM PC3 0.478 6317 2446 701 demeclocycline 8 µM PC3 0.478 4267 2447 626 alpha-estradiol 10 nM MCF7 0.478 1635 2448 735 baclofen 19 µM MCF7 0.478 5414 2449 715 midecamycin 5 µM PC3 0.478 6745 2450 712 bromocriptine 5 µM PC3 0.478 4604 2451 687 trichostatin A 100 nM MCF7 0.478 3872 2452 702 eldeline 8 µM PC3 0.478 4306 2453 762 norﬂoxacin 13 µM PC3 0.477 7283 2454 752 butirosin 5 µM MCF7 0.477 6080 2455 662 aconitine 6 µM MCF7 0.477 2776 2456 603 tanespimycin 1 µM PC3 0.477 1218 2457 756 tiletamine 15 µM MCF7 0.477 6516 2458 623 practolol 15 µM HL60 0.477 1587 2459 710 estrone 15 µM PC3 0.477 6647 2460 603 estradiol 100 nM PC3 0.477 1208 2461 758 bephenium hydrox- 9 µM MCF7 0.477 5628 ynaphthoate 2462 631 N-acetylmuramic 14 µM HL60 0.477 1326 acid 2463 640 Prestwick-559 8 µM HL60 0.477 1728 2464 627 todralazine 15 µM MCF7 0.476 1677 2465 504 depudecin 1 µM MCF7 0.476 874 2466 736 iopanoic acid 7 µM MCF7 0.476 5448 2467 701 ketoprofen 16 µM PC3 0.476 4286 2468 713 cotinine 23 µM PC3 0.476 4650 2469 758 clozapine 12 µM MCF7 0.476 5630 2470 732 ﬂuorometholone 11 µM PC3 0.476 5771

64 2471 644 trimethylcolchicinic 12 µM HL60 0.476 2146 acid 2472 656 colistin 3 µM MCF7 0.476 2851 2473 732 azlocillin 8 µM PC3 0.476 5788 2474 650 ﬂuphenazine 10 µM HL60 0.476 2697 2475 663 picrotoxinin 14 µM MCF7 0.476 2816 2476 719 thiocolchicoside 7 µM PC3 0.476 5095 2477 705 sulpiride 12 µM MCF7 0.475 4389 2478 628 metrifonate 16 µM PC3 0.475 1797 2479 653 bezaﬁbrate 11 µM MCF7 0.475 2630 2480 35 trichostatin A 100 nM HL60 0.475 364 2481 761 glafenine 10 µM PC3 0.475 7257 2482 767 tretinoin 1 µM MCF7 0.475 6931 2483 623 vanoxerine 8 µM HL60 0.475 1625 2484 709 omeprazole 12 µM PC3 0.475 6606 2485 1022 F0447-0125 10 µM MCF7 0.475 6396 2486 693 R-atenolol 15 µM PC3 0.475 4259 2487 767 valproic acid 50 µM MCF7 0.474 6941 2488 729 nicotinic acid 32 µM MCF7 0.474 5301 2489 729 diltiazem 9 µM MCF7 0.474 5309 2490 678 propoxycaine 12 µM MCF7 0.474 3583 2491 762 iobenguane 11 µM PC3 0.474 7299 2492 747 meropenem 10 µM MCF7 0.474 7180 2493 631 fusaric acid 22 µM HL60 0.474 1308 2494 702 eucatropine 12 µM PC3 0.474 4316 2495 1069 SB-203580 1 µM PC3 0.474 7066 2496 746 ifosfamide 15 µM MCF7 0.474 6279 2497 708 practolol 15 µM MCF7 0.474 5664 2498 612 tolazoline 20 µM HL60 0.474 2000 2499 619 lisinopril 9 µM HL60 0.474 2371 2500 695 cyclopenthiazide 11 µM MCF7 0.474 4813 2501 737 norethisterone 13 µM MCF7 0.473 5474 2502 1082 meteneprost 10 µM MCF7 0.473 7500 2503 761 aceclofenac 11 µM PC3 0.473 7269 2504 634 metixene 12 µM HL60 0.473 2451 2505 613 diltiazem 9 µM HL60 0.473 2032 2506 695 gibberellic acid 12 µM MCF7 0.473 4818 2507 754 raubasine 10 µM PC3 0.473 6360 2508 627 isoxicam 12 µM MCF7 0.473 1698 2509 613 azathioprine 14 µM HL60 0.473 2028 2510 741 harmol 16 µM MCF7 0.473 6022

65 2511 615 tranylcypromine 24 µM HL60 0.473 1417 2512 766 aceclofenac 11 µM MCF7 0.473 7029 2513 764 ramipril 10 µM PC3 0.472 7144 2514 1000 AG-013608 10 µM MCF7 0.472 5904 2515 734 glibenclamide 8 µM PC3 0.472 5849 2516 513 trichostatin A 1 µM MCF7 0.472 1072 2517 720 pramocaine 12 µM MCF7 0.472 4368 2518 1085 16- 10 µM PC3 0.472 7509 phenyltetranorprostaglandin E2 2519 701 medrysone 12 µM PC3 0.472 4266 2520 725 troglitazone 10 µM MCF7 0.472 5229 2521 25 LY-294002 10 µM MCF7 0.472 318 2522 698 salbutamol 17 µM PC3 0.472 7376 2523 688 trichostatin A 100 nM PC3 0.472 3993 2524 737 denatonium ben- 9 µM MCF7 0.472 5480 zoate 2525 633 aciclovir 18 µM MCF7 0.472 1543 2526 505 5162773 7 µM MCF7 0.472 892 2527 714 estradiol 15 µM PC3 0.472 6718 2528 645 Prestwick-664 8 µM HL60 0.471 2178 2529 688 oxybuprocaine 12 µM PC3 0.471 3996 2530 677 lansoprazole 11 µM MCF7 0.471 3529 2531 694 trimethylcolchicinic 12 µM MCF7 0.471 4787 acid 2532 1016 PF-01378883-00 10 µM MCF7 0.471 6363 2533 715 rolitetracycline 8 µM PC3 0.471 6731 2534 685 metoclopramide 12 µM MCF7 0.471 3625 2535 1034 5194442 20 µM PC3 0.471 6553 2536 622 guanethidine 13 µM HL60 0.471 1554 2537 762 netilmicin 3 µM PC3 0.471 7302 2538 635 etifenin 12 µM HL60 0.471 2477 2539 631 calcium pantothen- 8 µM HL60 0.471 1311 ate 2540 653 domperidone 7 µM MCF7 0.471 2655 2541 756 adipiodone 4 µM MCF7 0.471 6490 2542 670 guaifenesin 20 µM MCF7 0.471 3431 2543 616 acenocoumarol 11 µM PC3 0.471 2077 2544 762 phenindione 18 µM PC3 0.471 7289 2545 758 butyl hydroxyben- 21 µM MCF7 0.47 5608 zoate 2546 712 oleandomycin 5 µM PC3 0.47 4615 2547 1088 suramin sodium 10 µM MCF7 0.47 7524

66 2548 629 epirizole 17 µM HL60 0.47 1845 2549 719 scoulerine 12 µM PC3 0.47 5111 2550 689 propylthiouracil 23 µM PC3 0.47 4076 2551 734 vidarabine 15 µM PC3 0.47 5850 2552 712 procainamide 15 µM PC3 0.47 4602 2553 677 netilmicin 3 µM MCF7 0.47 3524 2554 614 cefotaxime 8 µM HL60 0.47 1389 2555 505 5213008 18 µM MCF7 0.469 898 2556 631 buﬂomedil 12 µM HL60 0.469 1338 2557 685 6- 18 µM MCF7 0.469 3623 benzylaminopurine 2558 680 pentolonium 7 µM PC3 0.469 3676 2559 703 2,6- 27 µM PC3 0.469 4543 dimethylpiperidine 2560 655 colecalciferol 10 µM MCF7 0.469 3298 2561 513 nordihydroguaiaretic 1 µM MCF7 0.469 1061 acid 2562 506 estradiol 100 nM MCF7 0.469 988 2563 613 baclofen 19 µM HL60 0.469 2036 2564 73 staurosporine 10 nM SKMEL5 0.469 508 2565 504 5279552 22 µM MCF7 0.469 843 2566 653 bisoprolol 9 µM MCF7 0.469 2642 2567 757 sirolimus 100 nM MCF7 0.469 5602 2568 752 ﬂuorometholone 11 µM MCF7 0.469 6071 2569 95 geldanamycin 1 µM MCF7 0.468 593 2570 746 bupropion 14 µM MCF7 0.468 6256 2571 765 rosiglitazone 10 µM MCF7 0.468 6992 2572 691 carteolol 12 µM MCF7 0.468 4176 2573 603 LY-294002 10 µM PC3 0.468 1239 2574 636 clindamycin 9 µM MCF7 0.468 2219 2575 762 ethosuximide 28 µM PC3 0.468 7308 2576 702 vincamine 11 µM PC3 0.468 4341 2577 738 rilmenidine 8 µM MCF7 0.468 5532 2578 1020 5707885 50 µM MCF7 0.468 6385 2579 705 etamsylate 15 µM MCF7 0.468 4399 2580 513 LY-294002 100 nM MCF7 0.468 1054 2581 682 metamizole sodium 12 µM PC3 0.467 3754 2582 732 butamben 21 µM PC3 0.467 5792 2583 633 midecamycin 5 µM MCF7 0.467 1526 2584 693 minaprine 11 µM PC3 0.467 4230 2585 699 PNU-0251126 1 µM MCF7 0.467 4714 2586 680 mephentermine 9 µM PC3 0.467 3685

67 2587 741 diphenhydramine 14 µM MCF7 0.467 6020 2588 699 fludroxycortide 9 µM MCF7 0.467 4702 2589 101 geldanamycin 1 µM MCF7 0.467 611 2590 603 haloperidol 10 µM PC3 0.467 1244 2591 1000 trichostatin A 1 µM MCF7 0.466 5903 2592 687 pramocaine 12 µM MCF7 0.466 3894 2593 619 pinacidil 16 µM HL60 0.466 2406 2594 603 chlorpromazine 1 µM PC3 0.466 1217 2595 628 triflupromazine 10 µM PC3 0.466 1813 2596 1077 lomustine 100 µM PC3 0.466 7094 2597 505 quercetin 1 µM MCF7 0.466 917 2598 702 mexiletine 19 µM PC3 0.466 4338 2599 755 nitrendipine 11 µM MCF7 0.465 6464 2600 1004 sirolimus 100 nM MCF7 0.465 5927 2601 678 dorzolamide 11 µM MCF7 0.465 3565 2602 753 melatonin 17 µM PC3 0.465 6293 2603 703 lithocholic acid 11 µM PC3 0.465 4551 2604 622 fluphenazine 8 µM HL60 0.465 1577 2605 753 clopamide 12 µM PC3 0.465 6301 2606 680 Prestwick-665 12 µM PC3 0.465 3681 2607 690 cefotetan 7 µM MCF7 0.465 4116 2608 719 flumequine 15 µM PC3 0.464 5104 2609 748 oxprenolol 13 µM MCF7 0.464 7225 2610 616 pindolol 16 µM PC3 0.464 2075 2611 752 streptozocin 15 µM MCF7 0.464 6098 2612 750 LY-294002 10 µM HL60 0.464 6195 2613 698 PNU-0251126 10 µM PC3 0.464 7388 2614 613 famotidine 12 µM HL60 0.464 2029 2615 718 octopamine 21 µM PC3 0.464 5050 2616 650 valproic acid 200 µM HL60 0.464 2674 2617 612 cinchocaine 12 µM HL60 0.463 1969 2618 714 fluvastatin 9 µM PC3 0.463 6691 2619 1090 CP-319743 10 µM MCF7 0.463 7532 2620 612 idoxuridine 11 µM HL60 0.463 1980 2621 659 paracetamol 26 µM HL60 0.463 3025 2622 708 terguride 9 µM MCF7 0.463 5694 2623 764 picotamide 10 µM PC3 0.463 7140 2624 635 tiabendazole 20 µM HL60 0.463 2479 2625 720 thiamazole 35 µM MCF7 0.463 4372 2626 654 7- 15 µM MCF7 0.462 3258 aminocephalosporanic acid

68 2627 686 ﬂecainide 8 µM MCF7 0.462 3843 2628 719 oxolinic acid 15 µM PC3 0.462 5094 2629 712 hycanthone 11 µM PC3 0.462 4630 2630 737 diethylcarbamazine 10 µM MCF7 0.462 5485 2631 714 diltiazem 9 µM PC3 0.462 6710 2632 704 sparteine 17 µM PC3 0.462 4568 2633 727 monorden 100 nM PC3 0.462 4443 2634 1078 thapsigargin 100 nM MCF7 0.462 7100 2635 623 desipramine 13 µM HL60 0.462 1596 2636 681 tropicamide 14 µM PC3 0.462 3722 2637 82 deferoxamine 100 µM MCF7 0.461 573 2638 709 fursultiamine 9 µM PC3 0.461 6630 2639 683 levcycloserine 39 µM PC3 0.461 3789 2640 700 metoclopramide 12 µM MCF7 0.461 4750 2641 1053 AG-012559 10 µM MCF7 0.461 6889 2642 719 enilconazole 13 µM PC3 0.461 5113 2643 714 trichostatin A 100 nM PC3 0.461 6709 2644 1074 CAY-10397 10 µM MCF7 0.461 7082 2645 698 cefamandole 8 µM PC3 0.461 7394 2646 741 Trolox C 16 µM MCF7 0.46 6007 2647 653 oxantel 7 µM MCF7 0.46 2632 2648 751 karakoline 11 µM MCF7 0.46 6059 2649 628 noretynodrel 13 µM PC3 0.46 1818 2650 622 bupropion 14 µM HL60 0.46 1564 2651 618 indapamide 11 µM HL60 0.46 2361 2652 735 clebopride 8 µM MCF7 0.46 5412 2653 734 estriol 14 µM PC3 0.46 5866 2654 630 clomifene 7 µM HL60 0.46 1269 2655 738 mometasone 8 µM MCF7 0.46 5541 2656 735 oxybenzone 18 µM MCF7 0.459 5410 2657 622 fendiline 11 µM HL60 0.459 1573 2658 618 lomeﬂoxacin 10 µM HL60 0.459 2348 2659 680 nitrofurantoin 17 µM PC3 0.459 3674 2660 714 methylergometrine 9 µM PC3 0.459 6704 2661 731 trioxysalen 18 µM PC3 0.459 5736 2662 28 trichostatin A 100 nM MCF7 0.459 332 2663 720 CP-690334-01 1 µM MCF7 0.459 4383 2664 622 trichostatin A 100 nM HL60 0.459 1561 2665 1044 AG-028671 10 µM PC3 0.459 6582 2666 614 dexamethasone 9 µM HL60 0.459 1396 2667 116 monastrol 100 µM PC3 0.459 668

69 2668 711 pempidine 13 µM MCF7 0.459 3926 2669 734 quipazine 9 µM PC3 0.459 5887 2670 640 propafenone 11 µM HL60 0.459 1722 2671 748 acenocoumarol 11 µM MCF7 0.459 7232 2672 726 flurbiprofen 16 µM MCF7 0.458 5269 2673 732 cefuroxime 9 µM PC3 0.458 5787 2674 654 metrizamide 5 µM MCF7 0.458 3255 2675 694 digitoxigenin 11 µM MCF7 0.458 4801 2676 734 bergenin 12 µM PC3 0.458 5870 2677 756 esculetin 22 µM MCF7 0.458 6499 2678 642 6- 18 µM MCF7 0.458 2313 benzylaminopurine 2679 689 corticosterone 12 µM PC3 0.458 4064 2680 640 scoulerine 12 µM HL60 0.458 1742 2681 712 niridazole 19 µM PC3 0.458 4621 2682 687 CP-690334-01 1 µM MCF7 0.458 3909 2683 741 triamterene 16 µM MCF7 0.458 6010 2684 712 josamycin 5 µM PC3 0.458 4631 2685 616 gentamicin 3 µM PC3 0.458 2082 2686 741 chenodeoxycholic 10 µM MCF7 0.458 6012 acid 2687 82 novobiocin 100 µM MCF7 0.457 576 2688 735 pralidoxime 23 µM MCF7 0.457 5383 2689 676 fluvoxamine 9 µM MCF7 0.457 7333 2690 709 sulfabenzamide 14 µM PC3 0.457 6634 2691 602 estradiol 100 nM HL60 0.457 1149 2692 654 chlorogenic acid 11 µM MCF7 0.457 3282 2693 754 betazole 27 µM PC3 0.457 6344 2694 715 caffeic acid 22 µM PC3 0.457 6753 2695 640 triflusal 16 µM HL60 0.457 1717 2696 614 spironolactone 10 µM HL60 0.456 1380 2697 758 equilin 15 µM MCF7 0.456 5620 2698 701 fenoprofen 7 µM PC3 0.456 4274 2699 703 spiradoline 1 µM PC3 0.456 4553 2700 692 roxithromycin 5 µM PC3 0.456 4192 2701 634 cephaeline 6 µM HL60 0.456 2429 2702 692 meptazinol 15 µM PC3 0.456 4188 2703 761 Prestwick-1082 12 µM PC3 0.456 7267 2704 628 carbamazepine 17 µM PC3 0.456 1805 2705 502 5230742 17 µM MCF7 0.455 970 2706 637 mefexamide 13 µM MCF7 0.455 2284 2707 660 flurbiprofen 16 µM HL60 0.455 3095

70 2708 678 estriol 14 µM MCF7 0.455 3563 2709 635 tetramisole 17 µM HL60 0.455 2489 2710 44 valproic acid 10 mM HL60 0.455 410 2711 685 sulfamethoxypyridazine14 µM MCF7 0.455 3609 2712 637 chlorzoxazone 24 µM MCF7 0.455 2263 2713 715 anisomycin 15 µM PC3 0.454 6764 2714 660 etynodiol 10 µM HL60 0.454 3102 2715 611 loperamide 8 µM PC3 0.454 1949 2716 755 megestrol 10 µM MCF7 0.454 6468 2717 736 isradipine 11 µM MCF7 0.454 5447 2718 753 dinoprost 8 µM PC3 0.454 6308 2719 750 valproic acid 50 µM HL60 0.454 6181 2720 761 mecamylamine 20 µM PC3 0.454 7263 2721 737 imidurea 10 µM MCF7 0.454 5481 2722 622 ﬁpexide 9 µM HL60 0.454 1560 2723 764 isopropamide 8 µM PC3 0.454 7133 iodide 2724 622 vinpocetine 11 µM HL60 0.454 1557 2725 700 nefopam 14 µM MCF7 0.454 4752 2726 651 doxycycline 8 µM HL60 0.453 2737 2727 746 naltrexone 10 µM MCF7 0.453 6241 2728 1003 rotenone 1 µM PC3 0.453 5920 2729 670 atractyloside 5 µM MCF7 0.453 3435 2730 695 dydrogesterone 13 µM MCF7 0.453 4836 2731 18 LM-1685 10 µM MCF7 0.453 253 2732 762 hydrastine hy- 10 µM PC3 0.453 7309 drochloride 2733 513 alpha-estradiol 10 nM MCF7 0.453 1048 2734 741 ketorolac 11 µM MCF7 0.453 5988 2735 711 acacetin 14 µM MCF7 0.452 3942 2736 1071 PHA-00816795 10 µM PC3 0.452 7072 2737 719 sulfadiazine 16 µM PC3 0.452 5098 2738 733 natamycin 6 µM PC3 0.452 5809 2739 718 diprophylline 16 µM PC3 0.452 5063 2740 713 probucol 8 µM PC3 0.452 4666 2741 660 estrone 15 µM HL60 0.452 3071 2742 735 chlorhexidine 8 µM MCF7 0.452 5403 2743 41 tretinoin 1 µM HL60 0.452 390 2744 718 tridihexethyl 11 µM PC3 0.452 5067 2745 659 monobenzone 20 µM HL60 0.452 3054 2746 617 mafenide 18 µM PC3 0.452 2124 2747 645 acacetin 14 µM HL60 0.452 2189

71 2748 616 trichostatin A 100 nM PC3 0.452 2084 2749 651 raloxifene 8 µM HL60 0.451 2738 2750 664 benzathine ben- 4 µM HL60 0.451 2939 zylpenicillin 2751 1080 BCB000040 10 µM MCF7 0.451 7488 2752 650 sirolimus 100 nM HL60 0.451 2681 2753 755 prazosin 10 µM MCF7 0.451 6475 2754 728 sulfanilamide 23 µM PC3 0.451 4474 2755 611 trichostatin A 100 nM PC3 0.451 1951 2756 640 chloroquine 8 µM HL60 0.45 1719 2757 673 dimethadione 31 µM MCF7 0.45 3367 2758 613 hydroxyzine 9 µM HL60 0.45 2024 2759 706 theobromine 22 µM MCF7 0.45 4958 2760 731 alclometasone 8 µM PC3 0.45 5752 2761 733 doxycycline 8 µM PC3 0.45 5838 2762 754 scopolamine N- 10 µM PC3 0.45 6335 oxide 2763 692 colistin 3 µM PC3 0.45 4212 2764 614 meﬂoquine 10 µM HL60 0.45 1364 2765 726 aciclovir 18 µM MCF7 0.45 5278 2766 737 pirlindole 12 µM MCF7 0.45 5497 2767 653 dextromethorphan 11 µM MCF7 0.45 2636 2768 1019 STOCK1N-35215 10 µM PC3 0.45 6380 2769 628 nifedipine 12 µM PC3 0.45 1814 2770 640 mesoridazine 7 µM HL60 0.449 1725 2771 622 cinnarizine 11 µM HL60 0.449 1558 2772 702 indapamide 11 µM PC3 0.449 4335 2773 752 alclometasone 8 µM MCF7 0.449 6094 2774 715 cefotiam 7 µM PC3 0.449 6762 2775 702 PHA-00851261E 1 µM PC3 0.449 4333 2776 710 velnacrine 12 µM PC3 0.449 6651 2777 513 valproic acid 50 µM MCF7 0.448 1060 2778 712 crotamiton 20 µM PC3 0.448 4628 2779 629 sulfadiazine 16 µM HL60 0.448 1852 2780 690 sisomicin 3 µM MCF7 0.448 4132 2781 633 hydroxyzine 9 µM MCF7 0.448 1524 2782 619 econazole 9 µM HL60 0.448 2396 2783 757 estradiol 10 nM MCF7 0.448 5601 2784 611 amoxapine 13 µM PC3 0.448 1931 2785 1086 11-deoxy-16,16- 10 µM MCF7 0.448 7514 dimethylprostaglandin E2

72 2786 729 ciproﬂoxacin 11 µM MCF7 0.448 5299 2787 650 trichostatin A 100 nM HL60 0.448 2672 2788 611 danazol 12 µM PC3 0.448 1954 2789 630 procainamide 15 µM HL60 0.448 1263 2790 681 trichostatin A 100 nM PC3 0.448 3746 2791 747 pseudopelletierine 21 µM MCF7 0.448 7184 2792 753 ganciclovir 16 µM PC3 0.447 6289 2793 46 clozapine 10 µM MCF7 0.447 416 2794 734 cefmetazole 8 µM PC3 0.447 5868 2795 745 cefepime 7 µM MCF7 0.447 6237 2796 749 trichostatin A 100 nM HL60 0.447 6143 2797 680 PNU-0251126 10 µM PC3 0.447 3689 2798 706 glimepiride 8 µM MCF7 0.447 4973 2799 693 nifuroxazide 15 µM PC3 0.447 4253 2800 630 buspirone 9 µM HL60 0.447 1282 2801 1079 0198306-0000 10 µM PC3 0.446 7102 2802 712 N-acetyl-L-leucine 23 µM PC3 0.446 4622 2803 651 corbadrine 22 µM HL60 0.446 2710 2804 649 cefazolin 8 µM HL60 0.446 2564 2805 1062 scriptaid 10 µM PC3 0.446 6919 2806 711 sulfachlorpyridazine 14 µM MCF7 0.446 3944 2807 764 yohimbine 10 µM PC3 0.446 7130 2808 709 naphazoline 16 µM PC3 0.446 6604 2809 683 tolbutamide 15 µM PC3 0.446 3804 2810 613 metolazone 11 µM HL60 0.445 2014 2811 733 Prestwick-689 10 µM PC3 0.445 5816 2812 735 aminophylline 10 µM MCF7 0.445 5395 2813 1008 AG-013608 10 µM MCF7 0.445 5944 2814 613 ciproﬂoxacin 11 µM HL60 0.445 2022 2815 710 dicloxacillin 8 µM PC3 0.445 6666 2816 658 trichostatin A 100 nM HL60 0.445 2993 2817 19 LY-294002 10 µM MCF7 0.445 258 2818 689 co-dergocrine mesi- 6 µM PC3 0.444 4071 late 2819 615 pargyline 20 µM HL60 0.444 1418 2820 735 amoxicillin 11 µM MCF7 0.444 5385 2821 734 praziquantel 13 µM PC3 0.444 5874 2822 718 torasemide 11 µM PC3 0.444 5057 2823 707 bretylium tosilate 10 µM MCF7 0.444 5020 2824 686 mepenzolate bro- 10 µM MCF7 0.444 3829 mide

73 2825 692 calcium pantothen- 8 µM PC3 0.444 4189 ate 2826 647 brinzolamide 10 µM MCF7 0.444 3230 2827 691 trimethadione 28 µM MCF7 0.444 4165 2828 703 diethylstilbestrol 15 µM PC3 0.444 4547 2829 688 troleandomycin 5 µM PC3 0.443 3985 2830 1071 CAY-10397 10 µM PC3 0.443 7071 2831 653 3-hydroxy-DL- 18 µM MCF7 0.443 2654 kynurenine 2832 700 PNU-0230031 10 µM MCF7 0.443 4754 2833 1009 rotenone 1 µM PC3 0.443 5948 2834 698 PNU-0251126 1 µM PC3 0.443 7390 2835 704 etamsylate 15 µM PC3 0.442 4576 2836 718 chloramphenicol 12 µM PC3 0.442 5047 2837 622 ketotifen 9 µM HL60 0.442 1583 2838 764 canrenoic acid 10 µM PC3 0.442 7135 2839 1021 orlistat 10 µM PC3 0.442 6388 2840 762 harmol 16 µM PC3 0.442 7320 2841 651 methazolamide 17 µM HL60 0.442 2733 2842 504 bucladesine 2 µM MCF7 0.442 842 2843 618 oﬂoxacin 11 µM HL60 0.441 2340 2844 737 minocycline 8 µM MCF7 0.441 5496 2845 733 terazosin 9 µM PC3 0.441 5831 2846 732 methacholine chlo- 20 µM PC3 0.441 5773 ride 2847 53 staurosporine 100 nM MCF7 0.441 423 2848 623 trichostatin A 100 nM HL60 0.441 1612 2849 736 benzonatate 7 µM MCF7 0.441 5435 2850 671 sulfamonomethoxine 14 µM MCF7 0.441 3484 2851 714 nicotinic acid 32 µM PC3 0.441 6702 2852 617 ornidazole 18 µM PC3 0.441 2109 2853 687 ﬂutamide 14 µM MCF7 0.441 3885 2854 645 beta-escin 3 µM HL60 0.441 2194 2855 712 kanamycin 7 µM PC3 0.441 4625 2856 703 CP-690334-01 10 µM PC3 0.441 4558 2857 698 guanadrel 8 µM PC3 0.44 7396 2858 1011 valinomycin 100 nM PC3 0.44 5962 2859 35 sodium phenylbu- 100 µM HL60 0.44 363 tyrate 2860 637 hyoscyamine 14 µM MCF7 0.44 2271 2861 747 cinnarizine 11 µM MCF7 0.44 7174 2862 709 harmaline 14 µM PC3 0.44 6623

74 2863 710 edrophonium chlo- 20 µM PC3 0.44 6655 ride 2864 727 fulvestrant 10 nM PC3 0.439 4462 2865 746 tremorine 15 µM MCF7 0.439 6273 2866 762 tiletamine 15 µM PC3 0.439 7311 2867 640 10- 19 µM HL60 0.439 1743 methoxyharmalan 2868 13 raloxifene 100 nM MCF7 0.439 202 2869 111 genistein 10 µM MCF7 0.439 638 2870 745 cytisine 21 µM MCF7 0.439 6217 2871 29 nitrendipine 10 µM MCF7 0.438 336 2872 689 trimethadione 28 µM PC3 0.438 4086 2873 732 methazolamide 17 µM PC3 0.438 5794 2874 1010 PF-00562151-00 10 µM MCF7 0.438 5954 2875 648 butamben 21 µM HL60 0.438 2531 2876 753 ascorbic acid 22 µM PC3 0.438 6306 2877 715 oxantel 7 µM PC3 0.437 6738 2878 514 3-hydroxy-DL- 9 µM MCF7 0.437 1109 kynurenine 2879 734 milrinone 19 µM PC3 0.437 5856 2880 651 iopamidol 5 µM HL60 0.437 2732 2881 689 amylocaine 15 µM PC3 0.437 4089 2882 117 monastrol 100 µM MCF7 0.437 681 2883 505 5186324 2 µM MCF7 0.437 900 2884 677 viomycin 5 µM MCF7 0.437 3541 2885 504 5230742 17 µM MCF7 0.437 862 2886 1065 AH-6809 1 µM PC3 0.437 7049 2887 756 gliquidone 8 µM MCF7 0.437 6505 2888 613 zimeldine 10 µM HL60 0.436 2012 2889 614 mianserin 13 µM HL60 0.436 1385 2890 33 valproic acid 10 mM MCF7 0.436 345 2891 13 sulfasalazine 100 µM MCF7 0.436 204 2892 732 tremorine 15 µM PC3 0.436 5799 2893 709 palmatine 10 µM PC3 0.436 6612 2894 1015 sirolimus 100 nM PC3 0.436 5980 2895 709 hydrochlorothiazide 13 µM PC3 0.436 6625 2896 1007 trichostatin A 1 µM PC3 0.436 5940 2897 731 physostigmine 6 µM PC3 0.436 5749 2898 613 naloxone 11 µM HL60 0.436 2006 2899 733 isoetarine 12 µM PC3 0.436 5812 2900 1006 trichostatin A 1 µM MCF7 0.436 5935 2901 709 Prestwick-682 6 µM PC3 0.435 6638

75 2902 635 nifuroxazide 15 µM HL60 0.435 2490 2903 714 phenylpropanolamine 21 µM PC3 0.435 6699 2904 752 butamben 21 µM MCF7 0.435 6093 2905 55 LY-294002 10 µM PC3 0.435 429 2906 755 bephenium hydrox- 9 µM MCF7 0.435 6466 ynaphthoate 2907 612 troleandomycin 5 µM HL60 0.435 1965 2908 612 hexamethonium 10 µM HL60 0.435 1982 bromide 2909 116 mercaptopurine 10 µM PC3 0.435 667 2910 754 isradipine 11 µM PC3 0.435 6347 2911 640 thiocolchicoside 7 µM HL60 0.435 1726 2912 733 meropenem 10 µM PC3 0.435 5824 2913 715 hesperetin 13 µM PC3 0.434 6750 2914 613 erythromycin 5 µM HL60 0.434 2010 2915 615 fenspiride 13 µM HL60 0.434 1422 2916 754 alverine 8 µM PC3 0.434 6345 2917 718 loracarbef 11 µM PC3 0.434 5073 2918 1026 PF-00539758-00 10 µM MCF7 0.434 6416 2919 732 hydroquinine 9 µM PC3 0.434 5789 2920 651 alimemazine 5 µM HL60 0.434 2736 2921 651 vidarabine 15 µM HL60 0.434 2706 2922 616 acetylsalicylsalicylic 13 µM PC3 0.434 2061 acid 2923 735 ampicillin 10 µM MCF7 0.434 5408 2924 647 chlormezanone 15 µM MCF7 0.433 3235 2925 683 ethotoin 20 µM PC3 0.433 3809 2926 641 pseudopelletierine 21 µM HL60 0.433 1774 2927 661 octopamine 21 µM HL60 0.433 3112 2928 1011 PF-00562151-00 10 µM PC3 0.433 5959 2929 5 alpha-estradiol 10 nM MCF7 0.433 122 2930 694 nystatin 4 µM MCF7 0.433 4807 2931 752 pheneticillin 10 µM MCF7 0.433 6105 2932 762 moracizine 9 µM PC3 0.433 7297 2933 761 dyclonine 12 µM PC3 0.433 7261 2934 692 propantheline bro- 9 µM PC3 0.433 4214 mide 2935 720 ethotoin 20 µM MCF7 0.433 4366 2936 755 oxybenzone 18 µM MCF7 0.433 6469 2937 622 alprenolol 14 µM HL60 0.432 1571 2938 1058 PF-00562151-00 10 µM PC3 0.432 6907 2939 733 dexpropranolol 14 µM PC3 0.432 5814 2940 689 carteolol 12 µM PC3 0.431 4096

76 2941 1080 15(S)-15- 10 µM MCF7 0.431 7489 methylprostaglandin E2 2942 1038 16,16- 10 µM PC3 0.43 6562 dimethylprostaglandin E2 2943 640 prenylamine 10 µM HL60 0.43 1737 2944 613 verapamil 8 µM HL60 0.43 2009 2945 702 lanatoside C 4 µM PC3 0.43 4328 2946 1011 estradiol 10 nM PC3 0.43 5960 2947 727 valproic acid 50 µM PC3 0.43 4446 2948 640 iobenguane 11 µM HL60 0.43 1729 2949 741 hydrastine hy- 10 µM MCF7 0.43 6011 drochloride 2950 603 fulvestrant 1 µM PC3 0.429 1205 2951 734 noscapine 10 µM PC3 0.429 5851 2952 514 BW-B70C 32 µM MCF7 0.429 1132 2953 753 terguride 12 µM PC3 0.429 6299 2954 29 azathioprine 100 µM MCF7 0.429 338 2955 706 fursultiamine 9 µM MCF7 0.429 4975 2956 613 loxapine 9 µM HL60 0.429 2016 2957 641 piperlongumine 13 µM HL60 0.429 1764 2958 615 thalidomide 15 µM HL60 0.428 1411 2959 738 sulfadiazine 16 µM MCF7 0.428 5523 2960 729 debrisoquine 9 µM MCF7 0.428 5288 2961 712 practolol 15 µM PC3 0.427 4603 2962 1 metformin 100 nM MCF7 0.427 3 2963 755 meglumine 20 µM MCF7 0.427 6445 2964 513 monorden 100 nM MCF7 0.427 1057 2965 734 nomifensine 11 µM PC3 0.427 5863 2966 642 phenelzine 17 µM MCF7 0.427 2319 2967 65 rofecoxib 10 µM PC3 0.427 463 2968 640 raubasine 10 µM HL60 0.427 1748 2969 514 demecolcine 12 µM MCF7 0.426 1103 2970 745 cyclopentolate 12 µM MCF7 0.426 6214 2971 617 oxolinic acid 15 µM PC3 0.426 2103 2972 680 oﬂoxacin 11 µM PC3 0.426 3673 2973 714 nitrofural 20 µM PC3 0.426 6721 2974 616 tranexamic acid 25 µM PC3 0.426 2085 2975 613 oleandomycin 5 µM HL60 0.426 2018 2976 734 atropine 6 µM PC3 0.425 5865 2977 682 ﬂecainide 8 µM PC3 0.425 3761 2978 709 methoxamine 16 µM PC3 0.425 6627

77 2979 31 2-deoxy-D-glucose 10 mM MCF7 0.425 344 2980 616 cefotaxime 8 µM PC3 0.424 2072 2981 614 triamcinolone 10 µM HL60 0.424 1395 2982 1047 16,16- 10 µM MCF7 0.424 6597 dimethylprostaglandin E2 2983 615 ranitidine 11 µM HL60 0.423 1404 2984 712 colchicine 10 µM PC3 0.423 4614 2985 1030 AG-013608 10 µM MCF7 0.423 6435 2986 1053 SB-202190 1 µM MCF7 0.423 6887 2987 761 atropine methoni- 11 µM PC3 0.423 7253 trate 2988 714 naftidrofuryl 8 µM PC3 0.423 6687 2989 611 bromocriptine 5 µM PC3 0.422 1925 2990 764 monocrotaline 12 µM PC3 0.422 7127 2991 640 imipenem 13 µM HL60 0.422 1724 2992 613 josamycin 5 µM HL60 0.422 2034 2993 90 resveratrol 50 µM PC3 0.421 662 2994 630 clozapine 12 µM HL60 0.421 1289 2995 710 etoposide 7 µM PC3 0.421 6681 2996 728 cefalotin 10 µM PC3 0.421 4482 2997 761 dihydroergocristine 6 µM PC3 0.421 7275 2998 641 physostigmine 6 µM HL60 0.421 1776 2999 751 ﬂudroxycortide 9 µM MCF7 0.421 6039 3000 655 cefotiam 7 µM MCF7 0.421 3319 3001 733 tomatidine 10 µM PC3 0.421 5808 3002 1004 fulvestrant 1 µM MCF7 0.421 5926 3003 614 tetracycline 8 µM HL60 0.421 1397 3004 1086 vinblastine 100 nM MCF7 0.42 7517 3005 623 kanamycin 7 µM HL60 0.42 1609 3006 687 chlorambucil 13 µM MCF7 0.42 3869 3007 617 pentetrazol 29 µM PC3 0.42 2092 3008 714 hesperidin 7 µM PC3 0.42 6714 3009 659 dimethadione 31 µM HL60 0.42 3029 3010 13 15-delta 10 µM MCF7 0.42 201 prostaglandin J2 3011 689 tobramycin 9 µM PC3 0.419 4081 3012 715 pipemidic acid 13 µM PC3 0.419 6752 3013 630 droperidol 11 µM HL60 0.419 1290 3014 632 minoxidil 19 µM MCF7 0.419 1496 3015 615 mefexamide 13 µM HL60 0.418 1438 3016 634 butoconazole 8 µM HL60 0.418 2427

78 3017 618 ethisterone 13 µM HL60 0.418 2366 3018 112 colchicine 100 nM MCF7 0.418 644 3019 683 oxaprozin 14 µM PC3 0.418 3794 3020 719 mefenamic acid 17 µM PC3 0.418 5109 3021 680 calcium folinate 8 µM PC3 0.418 3703 3022 640 gliclazide 12 µM HL60 0.418 1720 3023 1095 trichostatin A 1 µM PC3 0.417 7555 3024 42 alpha-estradiol 10 nM ssMCF7 0.417 403 3025 761 etamivan 18 µM PC3 0.417 7260 3026 678 benzylpenicillin 11 µM MCF7 0.417 3577 3027 682 bendroﬂumethiazide 9 µM PC3 0.417 3758 3028 732 papaverine 11 µM PC3 0.417 5769 3029 745 thiethylperazine 6 µM MCF7 0.417 6232 3030 701 tropicamide 14 µM PC3 0.415 4280 3031 712 droperidol 11 µM PC3 0.415 4629 3032 660 terguride 12 µM HL60 0.415 3082 3033 709 carisoprodol 15 µM PC3 0.415 6610 3034 610 dicycloverine 12 µM PC3 0.415 1902 3035 710 bemegride 26 µM PC3 0.414 6668 3036 651 clidinium bromide 9 µM HL60 0.414 2734 3037 736 10- 19 µM MCF7 0.414 5455 methoxyharmalan 3038 712 dioxybenzone 16 µM PC3 0.414 4638 3039 749 piretanide 11 µM HL60 0.414 6144 3040 765 genistein 10 µM MCF7 0.414 6994 3041 60 trichostatin A 100 nM PC3 0.414 448 3042 614 aminophenazone 17 µM HL60 0.414 1376 3043 709 liothyronine 6 µM PC3 0.414 6602 3044 1019 PF-00539758-00 10 µM PC3 0.414 6379 3045 718 diethylcarbamazine 10 µM PC3 0.413 5066 3046 701 betonicine 25 µM PC3 0.413 4301 3047 767 alpha-estradiol 10 nM MCF7 0.413 6930 3048 682 PHA-00851261E 10 µM PC3 0.413 3773 3049 728 amrinone 21 µM PC3 0.413 4488 3050 641 racecadotril 10 µM HL60 0.413 1782 3051 710 megestrol 10 µM PC3 0.413 6667 3052 764 ribostamycin 7 µM PC3 0.413 7123 3053 6 tamoxifen 1 µM MCF7 0.413 143 3054 715 zidovudine 15 µM PC3 0.412 6733 3055 610 amiloride 13 µM PC3 0.412 1890 3056 637 nimesulide 13 µM MCF7 0.412 2275

79 3057 622 praziquantel 13 µM HL60 0.412 1572 3058 713 bephenium hydrox- 9 µM PC3 0.412 4668 ynaphthoate 3059 612 sulfathiazole 16 µM HL60 0.412 1963 3060 1034 AG-028671 10 µM PC3 0.412 6557 3061 754 pinacidil 16 µM PC3 0.412 6356 3062 752 altizide 10 µM MCF7 0.411 6089 3063 687 paroxetine 1 µM MCF7 0.411 3904 3064 705 diphemanil metil- 10 µM MCF7 0.411 4416 sulfate 3065 718 gemfibrozil 16 µM PC3 0.411 5069 3066 704 tetramisole 17 µM PC3 0.41 4587 3067 1065 6-bromoindirubin- 500 nM PC3 0.41 7048 3’-oxime 3068 650 tanespimycin 1 µM HL60 0.41 2686 3069 761 moxisylyte 13 µM PC3 0.41 7255 3070 714 mimosine 20 µM PC3 0.41 6703 3071 693 picrotoxinin 14 µM PC3 0.41 4260 3072 683 alpha-ergocryptine 7 µM PC3 0.41 3817 3073 683 CP-690334-01 10 µM PC3 0.409 3823 3074 681 finasteride 11 µM PC3 0.409 3744 3075 734 acenocoumarol 11 µM PC3 0.409 5878 3076 745 trichostatin A 100 nM MCF7 0.409 6222 3077 708 crotamiton 20 µM MCF7 0.409 5689 3078 1 metformin 10 µM MCF7 0.408 2 3079 613 cotinine 23 µM HL60 0.408 2011 3080 761 aminocaproic acid 30 µM PC3 0.408 7258 3081 704 vitexin 9 µM PC3 0.408 4588 3082 614 trichostatin A 100 nM HL60 0.408 1400 3083 614 disulfiram 13 µM HL60 0.408 1369 3084 1017 PF-01378883-00 10 µM PC3 0.407 6368 3085 689 xylazine 18 µM PC3 0.407 4066 3086 720 lithocholic acid 11 µM MCF7 0.407 4373 3087 615 oxymetazoline 13 µM HL60 0.407 1431 3088 726 serotonin 19 µM MCF7 0.407 5268 3089 1014 sirolimus 100 nM MCF7 0.407 5975 3090 1020 0225151-0000 10 µM MCF7 0.406 6384 3091 709 Prestwick-857 12 µM PC3 0.405 6635 3092 764 drofenine 11 µM PC3 0.405 7129 3093 750 fulvestrant 10 nM HL60 0.405 6197 3094 701 karakoline 11 µM PC3 0.405 4297 3095 650 estradiol 100 nM HL60 0.404 2668

80 3096 39 cobalt chloride 100 µM MCF7 0.404 379 3097 682 proglumide 12 µM PC3 0.404 3780 3098 753 clebopride 8 µM PC3 0.404 6311 3099 622 antazoline 13 µM HL60 0.404 1556 3100 611 cyproheptadine 12 µM PC3 0.404 1938 3101 614 diazoxide 17 µM HL60 0.403 1368 3102 101 monastrol 100 µM MCF7 0.403 610 3103 751 flunisolide 9 µM MCF7 0.403 6023 3104 36 fulvestrant 1 µM MCF7 0.402 367 3105 612 naphazoline 16 µM HL60 0.402 1966 3106 682 PHA-00851261E 1 µM PC3 0.402 3776 3107 715 bisoprolol 9 µM PC3 0.402 6748 3108 109 colchicine 1 µM SKMEL5 0.402 630 3109 686 bendroflumethiazide 9 µM MCF7 0.402 3840 3110 82 copper sulfate 100 µM MCF7 0.402 575 3111 56 fasudil 10 µM PC3 0.401 436 3112 613 lisuride 12 µM HL60 0.401 2046 3113 109 valproic acid 1 mM SKMEL5 0.4 629 3114 628 dexpanthenol 19 µM PC3 0.4 1802 3115 1041 5155877 10 µM MCF7 0.399 6574 3116 628 sulfadiazine 16 µM PC3 0.399 1810 3117 1044 6-bromoindirubin- 500 nM PC3 0.399 6585 3’-oxime 3118 693 gibberellic acid 12 µM PC3 0.399 4234 3119 630 fusidic acid 7 µM HL60 0.398 1293 3120 689 furazolidone 18 µM PC3 0.398 4098 3121 58 oxamic acid 10 mM MCF7 0.397 439 3122 713 pentetic acid 10 µM PC3 0.397 4669 3123 5 dexamethasone 1 µM MCF7 0.397 123 3124 101 5666823 100 µM MCF7 0.397 609 3125 682 ethoxyquin 18 µM PC3 0.397 3764 3126 715 rolipram 15 µM PC3 0.397 6730 3127 640 dosulepin 12 µM HL60 0.396 1713 3128 69 fluphenazine 10 µM SKMEL5 0.396 494 3129 611 dipyridamole 8 µM PC3 0.396 1934 3130 641 folic acid 9 µM HL60 0.396 1790 3131 20 clofibrate 150 µM MCF7 0.396 263 3132 659 3-acetylcoumarin 21 µM HL60 0.396 3044 3133 20 ciclosporin 1 µM MCF7 0.396 261 3134 38 tamoxifen 1 µM ssMCF7 0.396 375 3135 614 dizocilpine 12 µM HL60 0.395 1386

81 3136 750 geldanamycin 1 µM HL60 0.395 6187 3137 603 trichostatin A 100 nM PC3 0.395 1212 3138 1052 AG-012559 10 µM PC3 0.395 6884 3139 659 caffeic acid 22 µM HL60 0.394 3053 3140 67 pirinixic acid 100 µM MCF7 0.394 487 3141 73 tanespimycin 1 µM SKMEL5 0.394 505 3142 714 tacrine 16 µM PC3 0.394 6698 3143 7 dexverapamil 10 µM MCF7 0.394 164 3144 611 apomorphine 6 µM PC3 0.394 1923 3145 640 bromperidol 10 µM HL60 0.393 1723 3146 733 clindamycin 9 µM PC3 0.393 5815 3147 610 levodopa 20 µM PC3 0.393 1892 3148 691 diflorasone 8 µM MCF7 0.393 4158 3149 693 emetine 7 µM PC3 0.393 4243 3150 612 captopril 17 µM HL60 0.392 1988 3151 640 hydrastine hy- 10 µM HL60 0.392 1740 drochloride 3152 1022 C-75 10 µM MCF7 0.392 6394 3153 610 amylocaine 15 µM PC3 0.392 1909 3154 614 naltrexone 10 µM HL60 0.392 1363 3155 709 theobromine 22 µM PC3 0.392 6613 3156 681 bromopride 12 µM PC3 0.391 3719 3157 513 fulvestrant 10 nM MCF7 0.391 1076 3158 754 Prestwick-1083 9 µM PC3 0.391 6357 3159 710 prasterone 12 µM PC3 0.391 6673 3160 1059 NS-398 10 µM MCF7 0.391 6911 3161 711 dicoumarol 12 µM MCF7 0.39 3941 3162 33 valproic acid 2 mM MCF7 0.39 346 3163 1052 SB-202190 1 µM PC3 0.39 6882 3164 70 valproic acid 1 mM ssMCF7 0.388 497 3165 705 iocetamic acid 7 µM MCF7 0.388 4425 3166 1028 C-75 10 µM MCF7 0.387 6423 3167 711 ethisterone 13 µM MCF7 0.387 3975 3168 651 hexylcaine 13 µM HL60 0.387 2708 3169 683 paroxetine 1 µM PC3 0.387 3821 3170 1010 tanespimycin 1 µM MCF7 0.386 5953 3171 733 trifluridine 14 µM PC3 0.386 5819 3172 720 citalopram 1 µM MCF7 0.386 4377 3173 714 meglumine 20 µM PC3 0.386 6685 3174 651 cicloheximide 14 µM HL60 0.386 2723 3175 33 valproic acid 500 µM MCF7 0.386 347

82 3176 616 ampyrone 20 µM PC3 0.385 2086 3177 622 benzydamine 12 µM HL60 0.384 1552 3178 56 novobiocin 100 µM PC3 0.384 435 3179 709 pyrazinamide 32 µM PC3 0.383 6617 3180 680 isocarboxazid 17 µM PC3 0.383 3684 3181 56 valproic acid 1 mM PC3 0.383 433 3182 713 cefalexin 11 µM PC3 0.383 4654 3183 658 scopolamine 12 µM HL60 0.381 3018 3184 623 methotrexate 9 µM HL60 0.381 1599 3185 628 isoxicam 12 µM PC3 0.381 1820 3186 514 (-)-catechin 11 µM MCF7 0.38 1101 3187 1044 STOCK1N-35874 14 µM PC3 0.38 6583 3188 701 phenformin 17 µM PC3 0.38 4283 3189 8 sulindac 100 µM MCF7 0.379 168 3190 29 nifedipine 10 µM MCF7 0.379 335 3191 611 glipizide 9 µM PC3 0.379 1926 3192 735 ganciclovir 16 µM MCF7 0.379 5389 3193 610 minoxidil 19 µM PC3 0.379 1914 3194 692 benzocaine 24 µM PC3 0.379 4224 3195 98 butein 10 µM MCF7 0.379 607 3196 1 metformin 10 µM MCF7 0.378 1 3197 610 trimethobenzamide 9 µM PC3 0.377 1920 3198 112 tioguanine 10 µM MCF7 0.377 642 3199 650 LY-294002 10 µM HL60 0.377 2696 3200 82 tetraethylenepentamine100 µM MCF7 0.376 574 3201 54 tanespimycin 1 µM MCF7 0.375 428 3202 1 metformin 1 mM MCF7 0.375 4 3203 615 iproniazid 14 µM HL60 0.375 1442 3204 1009 monorden 100 nM PC3 0.375 5952 3205 689 decamethonium 10 µM PC3 0.374 4094 bromide 3206 2 valproic acid 1 mM MCF7 0.374 23 3207 5 mesalazine 100 µM MCF7 0.373 124 3208 688 suprofen 15 µM PC3 0.373 4005 3209 750 trichostatin A 100 nM HL60 0.373 6171 3210 65 pirinixic acid 100 µM PC3 0.373 464 3211 715 ceforanide 8 µM PC3 0.373 6751 3212 41 estradiol 10 nM HL60 0.373 387 3213 7 rofecoxib 10 µM MCF7 0.371 166 3214 73 wortmannin 10 nM SKMEL5 0.371 506 3215 641 tetrahydroalstonine 11 µM HL60 0.371 1756

83 3216 61 tanespimycin 1 µM PC3 0.371 450 3217 734 mesalazine 26 µM PC3 0.37 5888 3218 704 sulpiride 12 µM PC3 0.37 4566 3219 68 monorden 100 nM MCF7 0.369 489 3220 36 imatinib 10 µM MCF7 0.369 366 3221 18 rofecoxib 10 µM MCF7 0.369 251 3222 683 citalopram 1 µM PC3 0.367 3820 3223 734 bucladesine 8 µM PC3 0.367 5886 3224 680 fludroxycortide 9 µM PC3 0.367 3679 3225 611 famotidine 12 µM PC3 0.365 1946 3226 733 nalbuphine 10 µM PC3 0.365 5820 3227 74 fulvestrant 1 µM ssMCF7 0.365 523 3228 685 ketoprofen 16 µM MCF7 0.365 3626 3229 610 isoxsuprine 12 µM PC3 0.365 1904 3230 612 lidocaine 15 µM HL60 0.364 1999 3231 612 amylocaine 15 µM HL60 0.364 1991 3232 96 nifedipine 10 µM MCF7 0.364 603 3233 120 colforsin 50 µM HL60 0.363 783 3234 709 oxolamine 9 µM PC3 0.363 6624 3235 613 metanephrine 17 µM HL60 0.362 2015 3236 107 4,5- 10 µM MCF7 0.362 624 dianilinophthalimide 3237 611 metanephrine 17 µM PC3 0.362 1933 3238 59 clofibrate 100 µM MCF7 0.362 444 3239 66 pirinixic acid 100 µM PC3 0.361 481 3240 62 cobalt chloride 100 µM MCF7 0.361 454 3241 693 sulfaguanidine 19 µM PC3 0.361 4257 3242 641 pyridoxine 19 µM HL60 0.361 1759 3243 612 minaprine 11 µM HL60 0.361 1968 3244 650 vorinostat 10 µM HL60 0.36 2680 3245 622 furosemide 12 µM HL60 0.359 1580 3246 628 betazole 27 µM PC3 0.359 1812 3247 622 amodiaquine 9 µM HL60 0.356 1570 3248 25 acetylsalicylic acid 100 µM MCF7 0.356 315 3249 702 fludrocortisone 9 µM PC3 0.354 4342 3250 692 zalcitabine 19 µM PC3 0.354 4215 3251 623 clorgiline 13 µM HL60 0.353 1604 3252 610 trichostatin A 100 nM PC3 0.353 1891 3253 623 debrisoquine 9 µM HL60 0.353 1591 3254 688 nafcillin 9 µM PC3 0.35 3983 3255 727 tanespimycin 1 µM PC3 0.35 4449

84 3256 623 chlorpropamide 14 µM HL60 0.348 1594 3257 514 doxycycline 14 µM MCF7 0.348 1113 3258 26b LY-294002 10 µM MCF7 0.347 328 3259 63 valproic acid 1 mM PC3 0.346 458 3260 2a metformin 10 µM MCF7 0.345 61 3261 37 troglitazone 10 µM HL60 0.345 370 3262 62 indometacin 100 µM MCF7 0.344 453 3263 1020 orlistat 10 µM MCF7 0.342 6383 3264 651 sulfamonomethoxine 14 µM HL60 0.341 2742 3265 610 tolnaftate 13 µM PC3 0.341 1919 3266 1022 AG-013608 10 µM MCF7 0.341 6395 3267 611 chlortetracycline 8 µM PC3 0.34 1958 3268 610 diﬂunisal 16 µM PC3 0.34 1908 3269 71 LY-294002 10 µM SKMEL5 0.34 501 3270 63 deferoxamine 100 µM PC3 0.34 460 3271 66 monorden 100 nM PC3 0.34 484 3272 610 minaprine 11 µM PC3 0.339 1888 3273 623 methapyrilene 13 µM HL60 0.339 1588 3274 610 cinchocaine 12 µM PC3 0.339 1889 3275 610 acebutolol 11 µM PC3 0.337 1911 3276 41 raloxifene 100 nM HL60 0.336 388 3277 611 metolazone 11 µM PC3 0.335 1932 3278 98 monastrol 20 µM MCF7 0.334 605 3279 610 prednisone 11 µM PC3 0.334 1897 3280 611 methotrexate 9 µM PC3 0.334 1957 3281 25 ﬂufenamic acid 10 µM MCF7 0.334 316 3282 59 arachidonic acid 10 µM MCF7 0.334 443 3283 68 dopamine 1 µM MCF7 0.333 491 3284 86 4,5- 10 µM PC3 0.332 578 dianilinophthalimide 3285 25 N- 10 µM MCF7 0.329 317 phenylanthranilic acid 3286 611 naloxone 11 µM PC3 0.328 1924 3287 611 paclitaxel 5 µM PC3 0.325 1959 3288 16 celecoxib 10 µM MCF7 0.323 206 3289 691 tiaprofenic acid 15 µM MCF7 0.321 4171 3290 611 zimeldine 10 µM PC3 0.32 1930 3291 611 cotinine 23 µM PC3 0.319 1929 3292 18 SC-58125 10 µM MCF7 0.317 254 3293 2 phenformin 10 µM MCF7 0.315 21 3294 651 cefoxitin 9 µM HL60 0.313 2735

85 3295 610 oxetacaine 9 µM PC3 0.312 1903 3296 23 sulindac 50 µM MCF7 0.312 307 3297 611 aciclovir 18 µM PC3 0.307 1960 3298 2 phenyl biguanide 10 µM MCF7 0.306 22 3299 108 monastrol 100 µM MCF7 0.303 627 3300 7 exemestane 10 nM MCF7 0.302 165 3301 610 khellin 15 µM PC3 0.3 1922 3302 610 sulfaguanidine 19 µM PC3 0.299 1913 3303 611 moroxydine 19 µM PC3 0.299 1944 3304 26b sirolimus 100 nM MCF7 0.29 326 3305 62 quinpirole 1 µM MCF7 0.286 456 3306 24 exisulind 50 µM MCF7 0.286 314 3307 611 baclofen 19 µM PC3 0.282 1952 3308 24 monastrol 100 µM MCF7 0.279 311 3309 19 dexamethasone 1 µM MCF7 0.278 255 3310 71 indometacin 100 µM SKMEL5 0.264 503 3311 69 iloprost 1 µM SKMEL5 0.259 496 3312 69 pirinixic acid 100 µM SKMEL5 0.232 495 3313 633 azacyclonol 15 µM MCF7 0 1520 3314 712 vanoxerine 8 µM PC3 0 4641 3315 687 diethylstilbestrol 15 µM MCF7 0 3895 3316 505 celecoxib 10 µM MCF7 0 922 3317 680 monensin 6 µM PC3 0 3704 3318 726 pirenperone 10 µM MCF7 0 5274 3319 654 betulinic acid 9 µM MCF7 0 3281 3320 709 lasalocid 7 µM PC3 0 6639 3321 725 15-delta 10 µM MCF7 0 5228 prostaglandin J2 3322 695 zuclopenthixol 9 µM MCF7 0 4843 3323 708 vanoxerine 8 µM MCF7 0 5702 3324 656 nifuroxazide 15 µM MCF7 0 2850 3325 685 gossypol 8 µM MCF7 0 3637 3326 680 levomepromazine 9 µM PC3 0 3701 3327 505 ikarugamycin 2 µM MCF7 0 918 3328 1068 0198306-0000 10 µM MCF7 0 7064 3329 642 trichostatin A 100 nM MCF7 0 2330 3330 1068 MG-262 100 nM MCF7 0 7063 3331 751 trichostatin A 100 nM MCF7 0 6064 3332 707 ciclopirox 15 µM MCF7 0 5023 3333 1068 SC-19220 10 µM MCF7 0 7060 3334 758 cephaeline 6 µM MCF7 0 5612

86 3335 665 tribenoside 8 µM HL60 0 2946 3336 753 hexetidine 12 µM PC3 0 6319 3337 1079 thapsigargin 100 nM PC3 0 7103 3338 758 clofazimine 8 µM MCF7 0 5642 3339 771 clemastine 9 µM MCF7 0 7443 3340 672 lasalocid 7 µM MCF7 0 3360 3341 634 ciclopirox 15 µM HL60 0 2456 3342 657 dihydroergocristine 6 µM MCF7 0 2895 3343 686 ethoxyquin 18 µM MCF7 0 3846 3344 772 halofantrine 7 µM MCF7 0 7469 3345 704 dicycloverine 12 µM PC3 0 4581 3346 626 haloperidol 10 µM MCF7 0 1669 3347 1017 erastin 20 µM PC3 0 6369 3348 656 lovastatin 10 µM MCF7 0 2854 3349 681 gossypol 8 µM PC3 0 3740 3350 700 ﬁnasteride 11 µM MCF7 0 4766 3351 665 procarbazine 16 µM HL60 0 2971 3352 706 lovastatin 10 µM MCF7 0 4978 3353 504 ionomycin 2 µM MCF7 0 871 3354 650 genistein 10 µM HL60 0 2695 3355 1068 SB-203580 1 µM MCF7 0 7061 3356 685 etiocholanolone 14 µM MCF7 0 3639 3357 661 Prestwick-983 17 µM HL60 0 3141 3358 700 betonicine 25 µM MCF7 0 4767 3359 751 ﬁnasteride 11 µM MCF7 0 6062 3360 656 pregnenolone 13 µM MCF7 0 2856 3361 647 clofazimine 8 µM MCF7 0 3239 3362 766 dihydroergocristine 6 µM MCF7 0 7034 3363 707 etynodiol 10 µM MCF7 0 5024 3364 685 benzamil 11 µM MCF7 0 3635 3365 673 digoxigenin 10 µM MCF7 0 3397 3366 505 carbamazepine 100 nM MCF7 0 919 3367 654 myricetin 13 µM MCF7 0 3270 3368 673 propranolol 14 µM MCF7 0 3396 3369 725 valproic acid 500 µM MCF7 0 5237 3370 656 quercetin 12 µM MCF7 0 2859 3371 726 cephaeline 6 µM MCF7 0 5247 3372 710 lisuride 12 µM PC3 0 6682 3373 725 wortmannin 10 nM MCF7 0 5240 3374 757 valproic acid 500 µM MCF7 0 5600 3375 616 thioproperazine 6 µM PC3 0 2073

87 3376 660 clioquinol 13 µM HL60 0 3084 3377 747 podophyllotoxin 10 µM MCF7 0 7198 3378 720 CP-690334-01 10 µM MCF7 0 4380 3379 772 cloxacillin 9 µM MCF7 0 7483 3380 725 clozapine 10 µM MCF7 0 5226 3381 653 anisomycin 15 µM MCF7 0 2658 3382 755 prasterone 12 µM MCF7 0 6474 3383 752 podophyllotoxin 10 µM MCF7 0 6103 3384 706 meclocycline 6 µM MCF7 0 4982 3385 725 sirolimus 100 nM MCF7 0 5239 3386 746 dexamethasone 9 µM MCF7 0 6271 3387 634 dinoprost 8 µM HL60 0 2446 3388 648 podophyllotoxin 10 µM HL60 0 2540 3389 712 domperidone 7 µM PC3 0 4640 3390 765 haloperidol 10 µM MCF7 0 7003 3391 1053 carmustine 100 µM MCF7 0 6888 3392 687 CP-320650-01 10 µM MCF7 0 3905 3393 634 hexetidine 12 µM HL60 0 2457 3394 645 pramocaine 12 µM HL60 0 2198 3395 767 clozapine 10 µM MCF7 0 6947 3396 655 cephaeline 6 µM MCF7 0 3290 3397 713 testosterone 12 µM PC3 0 4676 3398 713 pirenperone 10 µM PC3 0 4679 3399 617 nifenazone 13 µM PC3 0 2122 3400 672 nadolol 13 µM MCF7 0 3359 3401 79 15-delta 10 µM SKMEL5 0 564 prostaglandin J2 3402 726 timolol 9 µM MCF7 0 5280 3403 767 haloperidol 10 µM MCF7 0 6960 3404 751 etiocholanolone 14 µM MCF7 0 6060 3405 691 betulinic acid 9 µM MCF7 0 4181 3406 673 thioperamide 10 µM MCF7 0 3392 3407 670 diethylstilbestrol 15 µM MCF7 0 3429 3408 762 diphenhydramine 14 µM PC3 0 7318 3409 686 ﬂunisolide 9 µM MCF7 0 3828 3410 704 ciclosporin 3 µM PC3 0 4586 3411 726 thioperamide 10 µM MCF7 0 5270 3412 681 diphenylpyraline 13 µM PC3 0 3743 3413 654 naringenin 15 µM MCF7 0 3278 3414 641 dipivefrine 10 µM HL60 0 1752 3415 602 wortmannin 10 nM HL60 0 1184

88 3416 671 cicloheximide 14 µM MCF7 0 3464 3417 627 thiamphenicol 11 µM MCF7 0 1704 3418 710 ouabain 5 µM PC3 0 6680 3419 514 MG-132 21 µM MCF7 0 1140 3420 686 phentolamine 13 µM MCF7 0 3860 3421 626 valproic acid 500 µM MCF7 0 1665 3422 685 betonicine 25 µM MCF7 0 3642 3423 690 fluticasone 8 µM MCF7 0 4129 3424 613 chlortetracycline 8 µM HL60 0 2042 3425 649 monensin 6 µM HL60 0 2580 3426 1031 trichostatin A 1 µM PC3 0 6439 3427 765 wortmannin 10 nM MCF7 0 7002 3428 752 leflunomide 15 µM MCF7 0 6102 3429 653 N6- 14 µM MCF7 0 2626 methyladenosine 3430 754 tribenoside 8 µM PC3 0 6328 3431 772 Prestwick-983 17 µM MCF7 0 7480 3432 611 chlorhexidine 8 µM PC3 0 1942 3433 686 acacetin 14 µM MCF7 0 3849 3434 700 foliosidine 13 µM MCF7 0 4761 3435 703 fenbendazole 13 µM PC3 0 4542 3436 686 solasodine 10 µM MCF7 0 3830 3437 707 lisuride 12 µM MCF7 0 5028 3438 725 genistein 10 µM MCF7 0 5232 3439 685 diphenylpyraline 13 µM MCF7 0 3640 3440 640 clorsulon 11 µM HL60 0 1735 3441 745 (+)-chelidonine 11 µM MCF7 0 6236 3442 671 azlocillin 8 µM MCF7 0 3468 3443 641 demecarium bro- 6 µM HL60 0 1781 mide 3444 748 leflunomide 15 µM MCF7 0 7238 3445 614 nocodazole 13 µM HL60 0 1393 3446 737 diprophylline 16 µM MCF7 0 5482 3447 711 mexiletine 19 µM MCF7 0 3973 3448 686 mexiletine 19 µM MCF7 0 3862 3449 725 LY-294002 10 µM MCF7 0 5236 3450 680 merbromin 5 µM PC3 0 3700 3451 1031 AG-013608 10 µM PC3 0 6440 3452 1047 5194442 20 µM MCF7 0 6599 3453 1082 CP-944629 10 µM MCF7 0 7497 3454 710 diloxanide 12 µM PC3 0 6679 3455 713 clofazimine 8 µM PC3 0 4682

89 3456 757 clozapine 10 µM MCF7 0 5589 3457 602 genistein 10 µM HL60 0 1176 3458 772 mefexamide 13 µM MCF7 0 7478 3459 755 benserazide 14 µM MCF7 0 6482 3460 633 verapamil 8 µM MCF7 0 1509 3461 730 anisomycin 15 µM MCF7 0 5364 3462 662 vinburnine 14 µM MCF7 0 2781 3463 688 trihexyphenidyl 12 µM PC3 0 4015 3464 727 haloperidol 10 µM PC3 0 4427 3465 649 lithocholic acid 11 µM HL60 0 2571 3466 678 oxyphenbutazone 12 µM MCF7 0 3582 3467 649 trichostatin A 100 nM HL60 0 2566 3468 1001 trichostatin A 1 µM PC3 0 5908 3469 641 lobeline 11 µM HL60 0 1770 3470 706 khellin 15 µM MCF7 0 4987 3471 655 dicloxacillin 8 µM MCF7 0 3307 3472 686 0317956-0000 1 µM MCF7 0 3858 3473 685 myosmine 27 µM MCF7 0 3634 3474 690 trihexyphenidyl 12 µM MCF7 0 4133 3475 672 carbenoxolone 7 µM MCF7 0 3353 3476 1064 lomustine 100 µM MCF7 0 7045 3477 671 bergenin 12 µM MCF7 0 3467 3478 642 orphenadrine 13 µM MCF7 0 2318 3479 1009 AG-013608 10 µM PC3 0 5949 3480 728 cloﬁlium tosylate 8 µM PC3 0 4492 3481 603 sirolimus 100 nM PC3 0 1242 3482 718 ceftazidime 6 µM PC3 0 5054 3483 693 buﬂomedil 12 µM PC3 0 4258 3484 726 biperiden 11 µM MCF7 0 5279 3485 708 josamycin 5 µM MCF7 0 5692 3486 112 W-13 10 µM MCF7 0 643 3487 1051 BAS-012416453 38 µM MCF7 0 6880 3488 748 quipazine 9 µM MCF7 0 7240 3489 719 dropropizine 17 µM PC3 0 5106 3490 644 glimepiride 8 µM HL60 0 2154 3491 713 digoxigenin 10 µM PC3 0 4680 3492 1015 pioglitazone 10 µM PC3 0 5977 3493 649 alexidine 7 µM HL60 0 2576 3494 610 pyrimethamine 16 µM PC3 0 1894 3495 706 methyldopate 15 µM MCF7 0 4986 3496 640 mometasone 8 µM HL60 0 1746

90 3497 691 4- 20 µM MCF7 0 4175 hydroxyphenazone 3498 746 alpha-yohimbine 10 µM MCF7 0 6274 3499 682 vincamine 11 µM PC3 0 3784 3500 602 haloperidol 10 µM HL60 0 1185 3501 647 zaprinast 15 µM MCF7 0 3226 3502 504 5253409 17 µM MCF7 0 844 3503 728 isocorydine 12 µM PC3 0 4505 3504 771 isotretinoin 13 µM MCF7 0 7438 3505 613 danazol 12 µM HL60 0 2038 3506 707 brinzolamide 10 µM MCF7 0 5016 3507 685 foliosidine 13 µM MCF7 0 3636 3508 688 boldine 12 µM PC3 0 4004 3509 751 diphenylpyraline 13 µM MCF7 0 6061 3510 633 lynestrenol 14 µM MCF7 0 1537 3511 642 ﬂudrocortisone 9 µM MCF7 0 2328 3512 713 biperiden 11 µM PC3 0 4684 3513 725 haloperidol 10 µM MCF7 0 5241 3514 711 dantrolene 12 µM MCF7 0 3978 3515 764 methylprednisolone 11 µM PC3 0 7137 3516 681 betonicine 25 µM PC3 0 3745 3517 753 nimodipine 10 µM PC3 0 6320 3518 698 calcium folinate 8 µM PC3 0 7401 3519 614 clindamycin 9 µM HL60 0 1373 3520 701 etiocholanolone 14 µM PC3 0 4298 3521 764 cefapirin 9 µM PC3 0 7142 3522 687 spiradoline 1 µM MCF7 0 3901 3523 514 tyrphostin AG- 32 µM MCF7 0 1141 1478 3524 640 ajmaline 12 µM HL60 0 1749 3525 632 pheniramine 11 µM MCF7 0 1492 3526 657 ajmaline 12 µM MCF7 0 2899 3527 764 nocodazole 13 µM PC3 0 7145 3528 662 quipazine 9 µM MCF7 0 2782 3529 1033 PHA-00767505E 10 µM MCF7 0 6550 3530 672 furazolidone 18 µM MCF7 0 3358 3531 707 colecalciferol 10 µM MCF7 0 5002 3532 641 tomatidine 10 µM HL60 0 1754 3533 641 isocorydine 12 µM HL60 0 1787 3534 735 coralyne 10 µM MCF7 0 5418 3535 613 azacyclonol 15 µM HL60 0 2020 3536 706 oxolamine 9 µM MCF7 0 4969

91 3537 58 W-13 10 µM MCF7 0 440 3538 640 lobelanidine 11 µM HL60 0 1747 3539 690 nadolol 13 µM MCF7 0 4139 3540 714 loxapine 9 µM PC3 0 6694 3541 685 karakoline 11 µM MCF7 0 3638 3542 505 decitabine 100 nM MCF7 0 920 3543 634 vigabatrin 31 µM HL60 0 2452 3544 730 xamoterol 5 µM MCF7 0 5363 3545 686 citiolone 25 µM MCF7 0 3836 3546 1004 PF-00875133-00 10 µM MCF7 0 5923 3547 642 fenbufen 16 µM MCF7 0 2308 3548 641 hydroquinine 9 µM HL60 0 1775 3549 633 josamycin 5 µM MCF7 0 1534 3550 707 diloxanide 12 µM MCF7 0 5025 3551 725 rosiglitazone 10 µM MCF7 0 5230 3552 720 PHA-00745360 10 µM MCF7 0 4381 3553 772 quinpirole 16 µM MCF7 0 7481 3554 20 MK-886 1 µM MCF7 0 264 3555 704 levodopa 20 µM PC3 0 4571 3556 687 alpha-ergocryptine 7 µM MCF7 0 3900 3557 1023 F0447-0125 10 µM PC3 0 6401 3558 602 triﬂuoperazine 10 µM HL60 0 1165 3559 733 mifepristone 9 µM PC3 0 5827 3560 704 lidocaine 15 µM PC3 0 4596 3561 707 benzbromarone 9 µM MCF7 0 5015 3562 713 aciclovir 18 µM PC3 0 4683 3563 706 Prestwick-682 6 µM MCF7 0 4984 3564 691 furazolidone 18 µM MCF7 0 4178 3565 631 cefadroxil 11 µM HL60 0 1323 3566 690 benzathine ben- 4 µM MCF7 0 4140 zylpenicillin 3567 662 folic acid 9 µM MCF7 0 2783 3568 632 khellin 15 µM MCF7 0 1504 3569 699 PNU-0251126 10 µM MCF7 0 4711 3570 635 lovastatin 10 µM HL60 0 2494 3571 691 myricetin 13 µM MCF7 0 4170 3572 1091 11-deoxy-16,16- 10 µM PC3 0 7538 dimethylprostaglandin E2 3573 758 timolol 9 µM MCF7 0 5645 3574 755 estrone 15 µM MCF7 0 6448 3575 676 gabexate 10 µM MCF7 0 7357

92 3576 665 ozagrel 15 µM HL60 0 2942 3577 671 bucladesine 8 µM MCF7 0 3483 3578 720 CP-320650-01 1 µM MCF7 0 4382 3579 641 vinburnine 14 µM HL60 0 1788 3580 729 nitrofural 20 µM MCF7 0 5321 3581 766 meclofenamic acid 12 µM MCF7 0 7038 3582 686 PHA-00851261E 10 µM MCF7 0 3854 3583 617 iproniazid 14 µM PC3 0 2125 3584 622 glibenclamide 8 µM HL60 0 1546 3585 686 pempidine 13 µM MCF7 0 3832 3586 59 oligomycin 1 µM MCF7 0 442 3587 663 canadine 12 µM MCF7 0 2818 3588 671 iopromide 5 µM MCF7 0 3481 3589 647 hemicholinium 7 µM MCF7 0 3216 3590 613 perphenazine 10 µM HL60 0 2040 3591 637 metampicillin 10 µM MCF7 0 2286 3592 60 15-delta 10 µM PC3 0 446 prostaglandin J2 3593 1092 16- 10 µM MCF7 0 7541 phenyltetranorprostaglandin E2 3594 661 ribavirin 16 µM HL60 0 3142 3595 7a verapamil 10 µM MCF7 0 161 3596 98 thalidomide 100 µM MCF7 0 606 3597 713 clenbuterol 13 µM PC3 0 4671 3598 626 estradiol 10 nM MCF7 0 1666 3599 642 ethisterone 13 µM MCF7 0 2326 3600 648 leﬂunomide 15 µM HL60 0 2539 3601 727 valproic acid 500 µM PC3 0 4464 3602 60 diclofenac 10 µM PC3 0 445 3603 764 oxedrine 24 µM PC3 0 7150 3604 673 primidone 18 µM MCF7 0 3402 3605 678 kaempferol 14 µM MCF7 0 3579 3606 706 naphazoline 16 µM MCF7 0 4949 3607 756 azapropazone 13 µM MCF7 0 6522 3608 687 thiamazole 35 µM MCF7 0 3898 3609 736 pinacidil 16 µM MCF7 0 5456 3610 728 metoprolol 6 µM PC3 0 4508 3611 661 articaine 12 µM HL60 0 3138 3612 688 memantine 19 µM PC3 0 4017

93 3613 1089 15(S)-15- 10 µM PC3 0 7526 methylprostaglandin E2 3614 685 ﬁnasteride 11 µM MCF7 0 3641 3615 741 lansoprazole 11 µM MCF7 0 6009 3616 692 nystatin 4 µM PC3 0 4223 3617 673 diloxanide 12 µM MCF7 0 3399 3618 706 hydrochlorothiazide 13 µM MCF7 0 4970 3619 677 Prestwick-1103 20 µM MCF7 0 3540 3620 610 ticlopidine 13 µM PC3 0 1895 3621 730 bisoprolol 9 µM MCF7 0 5348 3622 736 nomegestrol 11 µM MCF7 0 5461 3623 686 dicoumarol 12 µM MCF7 0 3848 3624 615 chlorzoxazone 24 µM HL60 0 1416 3625 629 chlorpromazine 11 µM HL60 0 1864 3626 689 alprostadil 11 µM PC3 0 4099 3627 750 sirolimus 100 nM HL60 0 6167 3628 688 brompheniramine 9 µM PC3 0 4013 3629 706 harmaline 14 µM MCF7 0 4968 3630 637 mafenide 18 µM MCF7 0 2287 3631 633 edrophonium chlo- 20 µM MCF7 0 1519 ride 3632 613 moroxydine 19 µM HL60 0 2027 3633 720 PHA-00745360 1 µM MCF7 0 4384 3634 704 etilefrine 18 µM PC3 0 4590 3635 602 sirolimus 100 nM HL60 0 1183 3636 704 beclometasone 8 µM PC3 0 4580 3637 765 valproic acid 500 µM MCF7 0 6999 3638 657 harmalol 15 µM MCF7 0 2892 3639 771 prednisolone 11 µM MCF7 0 7424 3640 752 propidium iodide 6 µM MCF7 0 6104 3641 700 ﬂunixin 8 µM MCF7 0 4735 3642 766 Prestwick-1082 12 µM MCF7 0 7027 3643 634 melatonin 17 µM HL60 0 2431 3644 748 bambuterol 10 µM MCF7 0 7239 3645 650 valproic acid 500 µM HL60 0 2700 3646 1067 colforsin 500 nM PC3 0 7059 3647 687 Prestwick-1100 9 µM MCF7 0 3880 3648 649 alpha-ergocryptine 7 µM HL60 0 2572 3649 709 harpagoside 8 µM PC3 0 6636 3650 720 paroxetine 1 µM MCF7 0 4378 3651 753 prazosin 10 µM PC3 0 6315

94 3652 636 dizocilpine 12 µM MCF7 0 2232 3653 655 biperiden 11 µM MCF7 0 3321 3654 686 sulfadimidine 13 µM MCF7 0 3847 3655 75 SC-58125 10 µM HL60 0 542 3656 771 dropropizine 17 µM MCF7 0 7429 3657 623 clopamide 12 µM HL60 0 1605 3658 686 benfotiamine 9 µM MCF7 0 3837 3659 753 arecoline 17 µM PC3 0 6322 3660 754 acemetacin 10 µM PC3 0 6361 3661 748 convolamine 12 µM MCF7 0 7230 3662 637 iproniazid 14 µM MCF7 0 2288 3663 745 pheneticillin 10 µM MCF7 0 6239 3664 636 gentamicin 3 µM MCF7 0 2245 3665 629 acetohexamide 12 µM HL60 0 1870 3666 648 nadide 6 µM HL60 0 2529 3667 756 isradipine 11 µM MCF7 0 6508 3668 686 PHA-00851261E 1 µM MCF7 0 3857 3669 673 nizatidine 12 µM MCF7 0 3385 3670 603 troglitazone 10 µM PC3 0 1232 3671 1034 alprostadil 10 µM PC3 0 6555 3672 616 tetracycline 8 µM PC3 0 2080 3673 748 gabapentin 23 µM MCF7 0 7229 3674 682 ﬂudrocortisone 9 µM PC3 0 3785 3675 755 nimodipine 10 µM MCF7 0 6480 3676 673 xamoterol 5 µM MCF7 0 3401 3677 613 paclitaxel 5 µM HL60 0 2043 3678 756 Prestwick-983 17 µM MCF7 0 6520 3679 632 minaprine 11 µM MCF7 0 1468 3680 694 amantadine 10 µM MCF7 0 4806 3681 616 dexamethasone 9 µM PC3 0 2079 3682 772 ajmaline 12 µM MCF7 0 7484 3683 502 Y-27632 3 µM MCF7 0 948 3684 649 thiamazole 35 µM HL60 0 2570 3685 700 myosmine 27 µM MCF7 0 4759 3686 748 gentamicin 3 µM MCF7 0 7237 3687 1032 PHA-00767505E 10 µM PC3 0 6545 3688 771 dimenhydrinate 9 µM MCF7 0 7431 3689 1091 BCB000039 10 µM PC3 0 7536 3690 712 guanabenz 14 µM PC3 0 4642 3691 709 methyldopate 15 µM PC3 0 6640 3692 640 dirithromycin 5 µM HL60 0 1712

95 3693 681 etiocholanolone 14 µM PC3 0 3742 3694 689 gelsemine 12 µM PC3 0 4097 3695 614 dihydrostreptomycin 3 µM HL60 0 1391 3696 756 rilmenidine 8 µM MCF7 0 6512 3697 632 tolazoline 20 µM MCF7 0 1500 3698 681 foliosidine 13 µM PC3 0 3739 3699 644 rescinnamine 6 µM HL60 0 2130 3700 687 PHA-00745360 1 µM MCF7 0 3910 3701 766 adiphenine 11 µM MCF7 0 7037 3702 682 ethisterone 13 µM PC3 0 3783 3703 623 alfuzosin 9 µM HL60 0 1586 3704 686 proglumide 12 µM MCF7 0 3861 3705 687 phenelzine 17 µM MCF7 0 3884 3706 635 nystatin 4 µM HL60 0 2500 3707 663 Prestwick-682 6 µM MCF7 0 2819 3708 757 genistein 10 µM MCF7 0 5595 3709 691 amylocaine 15 µM MCF7 0 4169 3710 687 lithocholic acid 11 µM MCF7 0 3899 3711 685 phenformin 17 µM MCF7 0 3622 3712 640 thiamine 12 µM HL60 0 1744 3713 729 ambroxol 10 µM MCF7 0 5319 3714 695 Prestwick-967 26 µM MCF7 0 4833 3715 673 eticlopride 11 µM MCF7 0 3393 3716 728 (-)-isoprenaline 16 µM PC3 0 4495 3717 602 clozapine 10 µM HL60 0 1170 3718 613 chlorhexidine 8 µM HL60 0 2025 3719 681 nefopam 14 µM PC3 0 3730 3720 691 alprostadil 11 µM MCF7 0 4179 3721 690 brompheniramine 9 µM MCF7 0 4131 3722 718 isometheptene 8 µM PC3 0 5082 3723 617 meclofenamic acid 12 µM PC3 0 2128 3724 681 PNU-0230031 10 µM PC3 0 3732 3725 611 midecamycin 5 µM PC3 0 1943 3726 735 melatonin 17 µM MCF7 0 5393 3727 689 diﬂorasone 8 µM PC3 0 4077 3728 67 deferoxamine 100 µM MCF7 0 485 3729 686 0317956-0000 10 µM MCF7 0 3855 3730 631 meclocycline 6 µM HL60 0 1341 3731 628 triamterene 16 µM PC3 0 1819 3732 650 clozapine 10 µM HL60 0 2689 3733 672 indoprofen 14 µM MCF7 0 3345

96 3734 762 nifenazone 13 µM PC3 0 7314 3735 626 sirolimus 100 nM MCF7 0 1667 3736 1052 carmustine 100 µM PC3 0 6883 3737 1093 16- 10 µM PC3 0 7546 phenyltetranorprostaglandin E2 3738 1021 0225151-0000 10 µM PC3 0 6389 3739 741 Prestwick-1103 20 µM MCF7 0 6019 3740 653 hesperidin 7 µM MCF7 0 2648 3741 732 propidium iodide 6 µM PC3 0 5803 3742 692 pregnenolone 13 µM PC3 0 4218 3743 732 ifosfamide 15 µM PC3 0 5805 3744 676 benzathine ben- 4 µM MCF7 0 7359 zylpenicillin 3745 737 lobelanidine 11 µM MCF7 0 5500 3746 764 propoxycaine 12 µM PC3 0 7155 3747 660 megestrol 10 µM HL60 0 3091 3748 656 tetramisole 17 µM MCF7 0 2849 3749 617 pentoxifylline 14 µM PC3 0 2127 3750 610 naphazoline 16 µM PC3 0 1886 3751 1025 valdecoxib 10 µM PC3 0 6408 3752 690 canadine 12 µM MCF7 0 4138 3753 681 ketoprofen 16 µM PC3 0 3729 3754 711 ﬂudrocortisone 9 µM MCF7 0 3977 3755 676 fursultiamine 9 µM MCF7 0 7349 3756 1036 STOCK1N-35874 14 µM PC3 0 6561 3757 725 estradiol 10 nM MCF7 0 5238 3758 630 estradiol 15 µM HL60 0 1299 3759 705 etilefrine 18 µM MCF7 0 4415 3760 754 nomegestrol 11 µM PC3 0 6362 3761 691 solanine 5 µM MCF7 0 4166 3762 762 ribavirin 16 µM PC3 0 7316 3763 31 sodium phenylbu- 100 µM MCF7 0 341 tyrate 3764 753 oxybenzone 18 µM PC3 0 6309 3765 632 4- 20 µM MCF7 0 1497 hydroxyphenazone 3766 686 spiramycin 5 µM MCF7 0 3844 3767 633 lisuride 12 µM MCF7 0 1545 3768 708 guanabenz 14 µM MCF7 0 5703 3769 771 niﬂumic acid 14 µM MCF7 0 7430 3770 767 rosiglitazone 10 µM MCF7 0 6950

97 3771 610 doxylamine 10 µM PC3 0 1893 3772 631 cefixime 9 µM HL60 0 1310 3773 718 etofylline 18 µM PC3 0 5048 3774 615 piroxicam 12 µM HL60 0 1405 3775 688 fluticasone 8 µM PC3 0 4011 3776 766 viomycin 5 µM MCF7 0 7036 3777 631 N-acetyl-L-aspartic 23 µM HL60 0 1329 acid 3778 640 budesonide 9 µM HL60 0 1716 3779 1076 SC-19220 10 µM MCF7 0 7090 3780 647 ambroxol 10 µM MCF7 0 3238 3781 614 ampyrone 20 µM HL60 0 1402 3782 706 methoxamine 16 µM MCF7 0 4972 3783 758 methyldopa 19 µM MCF7 0 5637 3784 636 cefotaxime 8 µM MCF7 0 2235 3785 629 thiamphenicol 11 µM HL60 0 1867 3786 1032 dinoprostone 10 µM PC3 0 6547 3787 653 arecoline 17 µM MCF7 0 2657 3788 671 gabapentin 23 µM MCF7 0 3472 3789 738 cyclic adenosine 12 µM MCF7 0 5533 monophosphate 3790 664 gabexate 10 µM HL60 0 2937 3791 610 cimetidine 16 µM PC3 0 1884 3792 610 ethambutol 14 µM PC3 0 1900 3793 705 vancomycin 3 µM MCF7 0 4423 3794 603 fulvestrant 10 nM PC3 0 1238 3795 705 ethionamide 24 µM MCF7 0 4418 3796 671 amrinone 21 µM MCF7 0 3465 3797 637 chlorphenesin 16 µM MCF7 0 2279 3798 617 fenspiride 13 µM PC3 0 2106 3799 627 atracurium besilate 3 µM MCF7 0 1702 3800 629 isoflupredone 10 µM HL60 0 1873 3801 635 trimethadione 28 µM HL60 0 2486 3802 1074 PHA-00846566E 10 µM MCF7 0 7081 3803 710 etynodiol 10 µM PC3 0 6678 3804 1033 dinoprostone 10 µM MCF7 0 6552 3805 772 spaglumic acid 13 µM MCF7 0 7465 3806 629 metformin 24 µM HL60 0 1858 3807 654 bacampicillin 8 µM MCF7 0 3273 3808 614 midodrine 14 µM HL60 0 1403 3809 663 Prestwick-642 14 µM MCF7 0 2815 3810 661 Prestwick-920 14 µM HL60 0 3118

98 3811 691 L-methionine 22 µM MCF7 0 4151 sulfoximine 3812 694 canavanine 14 µM MCF7 0 4782 3813 692 scopolamine 12 µM PC3 0 4219 3814 704 Prestwick-692 7 µM PC3 0 4599 3815 634 ﬂuoxetine 12 µM HL60 0 2453 3816 738 bumetanide 11 µM MCF7 0 5542 3817 688 sulmazole 14 µM PC3 0 4009 3818 685 lomeﬂoxacin 10 µM MCF7 0 3620 3819 713 methyldopa 19 µM PC3 0 4677 3820 659 propranolol 14 µM HL60 0 3059 3821 617 cloxacillin 9 µM PC3 0 2126 3822 747 terazosin 9 µM MCF7 0 7187 3823 656 tiaprofenic acid 15 µM MCF7 0 2852 3824 731 terbutaline 7 µM PC3 0 5764 3825 687 ciclacillin 12 µM MCF7 0 3882 3826 734 gentamicin 3 µM PC3 0 5883 3827 718 levopropoxyphene 7 µM PC3 0 5083 3828 734 pirenzepine 9 µM PC3 0 5872 3829 766 pergolide 10 µM MCF7 0 7031 3830 709 cefaclor 10 µM PC3 0 6622 3831 720 spiradoline 1 µM MCF7 0 4375 3832 665 levopropoxyphene 7 µM HL60 0 2980 3833 610 idoxuridine 11 µM PC3 0 1899 3834 678 cefepime 7 µM MCF7 0 3581 3835 631 myricetin 13 µM HL60 0 1334 3836 1082 suramin sodium 10 µM MCF7 0 7496 3837 709 glimepiride 8 µM PC3 0 6628 3838 771 pinacidil 16 µM MCF7 0 7437 3839 655 iohexol 5 µM MCF7 0 3322 3840 743 cefoxitin 9 µM MCF7 0 6796 3841 35 sirolimus 100 nM HL60 0 362 3842 761 articaine 12 µM PC3 0 7272 3843 623 zidovudine 15 µM HL60 0 1595 3844 645 trichostatin A 100 nM HL60 0 2208 3845 735 2- 23 µM MCF7 0 5422 aminobenzenesulfonamide 3846 631 primaquine 9 µM HL60 0 1343 3847 682 mexiletine 19 µM PC3 0 3781 3848 1045 6-bromoindirubin- 500 nM MCF7 0 6589 3’-oxime 3849 635 pregnenolone 13 µM HL60 0 2497

99 3850 673 felbinac 19 µM MCF7 0 3398 3851 732 alpha-yohimbine 10 µM PC3 0 5800 3852 713 timolol 9 µM PC3 0 4685 3853 736 S-propranolol 14 µM MCF7 0 5444 3854 688 N-acetyl-L-aspartic 23 µM PC3 0 4007 acid 3855 603 rosiglitazone 10 µM PC3 0 1233 3856 649 glycopyrronium 10 µM HL60 0 2565 bromide 3857 672 iodixanol 3 µM MCF7 0 3362 3858 709 arcaine 15 µM PC3 0 6629 3859 705 Prestwick-642 14 µM MCF7 0 4419 3860 603 nordihydroguaiaretic 1 µM PC3 0 1223 acid 3861 631 corticosterone 12 µM HL60 0 1307 3862 661 enilconazole 13 µM HL60 0 3139 3863 653 estradiol 15 µM MCF7 0 2653 3864 656 vancomycin 3 µM MCF7 0 2858 3865 752 sulfapyridine 16 µM MCF7 0 6101 3866 670 glycopyrronium 10 µM MCF7 0 3427 bromide 3867 752 sulfaquinoxaline 12 µM MCF7 0 6090 3868 651 bucladesine 8 µM HL60 0 2741 3869 622 mifepristone 9 µM HL60 0 1569 3870 637 cloxacillin 9 µM MCF7 0 2289 3871 65 troglitazone 10 µM PC3 0 462 3872 8 amitriptyline 1 µM MCF7 0 167 3873 616 isoniazid 29 µM PC3 0 2083 3874 1049 STOCK1N-28457 20 µM MCF7 0 6869 3875 1025 PF-01378883-00 10 µM PC3 0 6410 3876 732 sulfamethizole 15 µM PC3 0 5798 3877 671 ifosfamide 15 µM MCF7 0 3485 3878 640 cyclizine 13 µM HL60 0 1731 3879 762 chenodeoxycholic 10 µM PC3 0 7310 acid 3880 654 SR-95639A 10 µM MCF7 0 3272 3881 764 antazoline 13 µM PC3 0 7128 3882 58 copper sulfate 100 µM MCF7 0 438 3883 685 nefopam 14 µM MCF7 0 3627 3884 1025 3-nitropropionic 10 µM PC3 0 6407 acid 3885 636 tranexamic acid 25 µM MCF7 0 2248 3886 650 haloperidol 10 µM HL60 0 2704 3887 634 nitrofural 20 µM HL60 0 2459

100 3888 741 ribavirin 16 µM MCF7 0 6018 3889 693 tolazoline 20 µM PC3 0 4262 3890 695 tocainide 17 µM MCF7 0 4838 3891 644 Prestwick-692 7 µM HL60 0 2165 3892 640 harmol 16 µM HL60 0 1750 3893 644 Prestwick-642 14 µM HL60 0 2160 3894 1003 PF-00562151-00 10 µM PC3 0 5922 3895 764 berberine 11 µM PC3 0 7143 3896 753 cefoperazone 6 µM PC3 0 6323 3897 698 glycopyrronium 10 µM PC3 0 7386 bromide 3898 661 ﬂucloxacillin 8 µM HL60 0 3128 3899 1087 BCB000038 10 µM PC3 0 7520 3900 20 indometacin 20 µM MCF7 0 262 3901 762 Prestwick-1103 20 µM PC3 0 7317 3902 663 benzocaine 24 µM MCF7 0 2822 3903 764 vinburnine 14 µM PC3 0 7154 3904 641 quipazine 9 µM HL60 0 1789 3905 1044 dinoprostone 10 µM PC3 0 6586 3906 747 folic acid 9 µM MCF7 0 7201 3907 627 acetohexamide 12 µM MCF7 0 1707 3908 75 monorden 100 nM HL60 0 544 3909 627 metformin 24 µM MCF7 0 1694 3910 677 ioxaglic acid 3 µM MCF7 0 3528 3911 706 cefaclor 10 µM MCF7 0 4967 3912 753 esculin 12 µM PC3 0 6310 3913 31 novobiocin 100 µM MCF7 0 342 3914 629 dapsone 16 µM HL60 0 1868 3915 728 iopromide 5 µM PC3 0 4504 3916 746 hexylcaine 13 µM MCF7 0 6244 3917 689 yohimbic acid 11 µM PC3 0 4082 3918 749 saquinavir 5 µM HL60 0 6127 3919 655 glycocholic acid 9 µM MCF7 0 3315 3920 762 heptaminol 22 µM PC3 0 7313 3921 680 sulfadimethoxine 13 µM PC3 0 3702 3922 648 pheneticillin 10 µM HL60 0 2542 3923 712 chlormezanone 15 µM PC3 0 4636 3924 709 khellin 15 µM PC3 0 6641 3925 686 piperacillin 7 µM MCF7 0 3845 3926 611 erythromycin 5 µM PC3 0 1928 3927 687 santonin 16 µM MCF7 0 3877

101 3928 649 sulfadimethoxine 13 µM HL60 0 2578 3929 712 androsterone 14 µM PC3 0 4635 3930 749 methanthelinium 10 µM HL60 0 6137 bromide 3931 707 dicloxacillin 8 µM MCF7 0 5012 3932 617 pargyline 20 µM PC3 0 2102 3933 702 ethisterone 13 µM PC3 0 4340 3934 648 cefmetazole 8 µM HL60 0 2524 3935 688 nadolol 13 µM PC3 0 4021 3936 711 vincamine 11 µM MCF7 0 3976 3937 1036 Gly-His-Lys 1 µM PC3 0 6560 3938 755 nilutamide 13 µM MCF7 0 6481 3939 699 sulfadimethoxine 13 µM MCF7 0 4724 3940 68 haloperidol 10 µM MCF7 0 492 3941 635 R-atenolol 15 µM HL60 0 2496 3942 634 trichostatin A 100 nM HL60 0 2450 3943 641 (+)-chelidonine 11 µM HL60 0 1786 3944 629 homatropine 11 µM HL60 0 1848 3945 637 pentoxifylline 14 µM MCF7 0 2290 3946 635 tiaprofenic acid 15 µM HL60 0 2492 3947 626 genistein 10 µM MCF7 0 1660 3948 1055 SB-203580 1 µM MCF7 0 6899 3949 683 PHA-00745360 1 µM PC3 0 3827 3950 1027 PF-00539758-00 10 µM PC3 0 6421 3951 616 triamcinolone 10 µM PC3 0 2078 3952 690 sulmazole 14 µM MCF7 0 4127 3953 613 lynestrenol 14 µM HL60 0 2037 3954 688 levobunolol 12 µM PC3 0 4016 3955 1075 CAY-10397 10 µM PC3 0 7087 3956 634 cisapride 9 µM HL60 0 2443 3957 690 chlorogenic acid 11 µM MCF7 0 4142 3958 702 dantrolene 12 µM PC3 0 4343 3959 514 yohimbine 23 µM MCF7 0 1119 3960 698 merbromin 5 µM PC3 0 7398 3961 641 noscapine 10 µM HL60 0 1753 3962 641 calycanthine 12 µM HL60 0 1771 3963 641 aconitine 6 µM HL60 0 1784 3964 712 felbinac 19 µM PC3 0 4639 3965 708 felbinac 19 µM MCF7 0 5700 3966 615 metampicillin 10 µM HL60 0 1440 3967 746 hydroquinine 9 µM MCF7 0 6263

102 3968 750 trichostatin A 1 µM HL60 0 6193 3969 632 tolnaftate 13 µM MCF7 0 1501 3970 641 berberine 11 µM HL60 0 1778 3971 676 ﬂuticasone 8 µM MCF7 0 7348 3972 693 quercetin 12 µM PC3 0 4264 3973 745 racecadotril 10 µM MCF7 0 6231 3974 688 gramine 23 µM PC3 0 3999 3975 733 pseudopelletierine 21 µM PC3 0 5828 3976 1004 pioglitazone 10 µM MCF7 0 5925 3977 603 estradiol 10 nM PC3 0 1241 3978 750 estradiol 10 nM HL60 0 6200 3979 633 famotidine 12 µM MCF7 0 1529 3980 634 amphotericin B 4 µM HL60 0 2441 3981 730 metanephrine 17 µM MCF7 0 5334 3982 70 novobiocin 100 µM ssMCF7 0 499 3983 754 10- 19 µM PC3 0 6355 methoxyharmalan 3984 629 heptaminol 22 µM HL60 0 1866 3985 771 acemetacin 10 µM MCF7 0 7442 3986 617 metampicillin 10 µM PC3 0 2123 3987 650 monorden 100 nM HL60 0 2679 3988 737 hydrastinine 16 µM MCF7 0 5494 3989 665 betulin 9 µM HL60 0 2952 3990 733 podophyllotoxin 10 µM PC3 0 5841 3991 1036 6-bromoindirubin- 500 nM PC3 0 6559 3’-oxime 3992 60 tretinoin 1 µM PC3 0 447 3993 1047 PHA-00767505E 10 µM MCF7 0 6596 3994 612 metronidazole 23 µM HL60 0 2003 3995 754 naproxen 17 µM PC3 0 6358 3996 688 canadine 12 µM PC3 0 4020 3997 505 topiramate 3 µM MCF7 0 915 3998 704 iocetamic acid 7 µM PC3 0 4600 3999 746 lobeline 11 µM MCF7 0 6258 4000 767 genistein 10 µM MCF7 0 6952 4001 692 amantadine 10 µM PC3 0 4222 4002 764 alprenolol 14 µM PC3 0 7141 4003 680 cefamandole 8 µM PC3 0 3696 4004 1087 11-deoxy-16,16- 10 µM PC3 0 7519 dimethylprostaglandin E2 4005 107 nocodazole 1 µM MCF7 0 621

103 4006 1001 estradiol 10 nM PC3 0 5910 4007 1094 vinblastine 100 nM MCF7 0 7551 4008 686 vincamine 11 µM MCF7 0 3865 4009 671 pyrithyldione 24 µM MCF7 0 3482 4010 713 3-hydroxy-DL- 18 µM PC3 0 4681 kynurenine 4011 644 benzocaine 24 µM HL60 0 2167 4012 700 karakoline 11 µM MCF7 0 4763 4013 1067 SB-202190 1 µM PC3 0 7058 4014 733 folic acid 9 µM PC3 0 5844 4015 631 lumicolchicine 10 µM HL60 0 1317 4016 17 tretinoin 1 µM MCF7 0 224 4017 635 tenoxicam 12 µM HL60 0 2501 4018 750 tretinoin 1 µM HL60 0 6170 4019 43 sodium phenylbu- 1 mM MCF7 0 407 tyrate 4020 702 0317956-0000 1 µM PC3 0 4334 4021 665 proguanil 14 µM HL60 0 2944 4022 771 lincomycin 9 µM MCF7 0 7411 4023 727 estradiol 10 nM PC3 0 4465 4024 719 bumetanide 11 µM PC3 0 5117 4025 661 rilmenidine 8 µM HL60 0 3133 4026 644 canadine 12 µM HL60 0 2163 4027 683 CP-320650-01 10 µM PC3 0 3822 4028 762 pentoxifylline 14 µM PC3 0 7319 4029 698 atractyloside 5 µM PC3 0 7393 4030 701 ﬁnasteride 11 µM PC3 0 4300 4031 659 primidone 18 µM HL60 0 3065 4032 644 Prestwick-682 6 µM HL60 0 2164 4033 749 Prestwick-1085 15 µM HL60 0 6131 4034 37 rofecoxib 10 µM HL60 0 371 4035 659 trichostatin A 100 nM HL60 0 3058 4036 758 biperiden 11 µM MCF7 0 5644 4037 635 vancomycin 3 µM HL60 0 2498 4038 733 ipratropium bro- 10 µM PC3 0 5823 mide 4039 629 diprophylline 16 µM HL60 0 1853 4040 1093 IC-86621 1 µM PC3 0 7548 4041 753 vigabatrin 31 µM PC3 0 6314 4042 663 succinylsulfathiazole 11 µM MCF7 0 2821 4043 611 verapamil 8 µM PC3 0 1927 4044 682 dantrolene 12 µM PC3 0 3786

104 4045 658 (+/-)-catechin 14 µM HL60 0 3012 4046 771 triprolidine 13 µM MCF7 0 7408 4047 683 tinidazole 16 µM PC3 0 3813 4048 1014 PF-00539745-00 10 µM MCF7 0 5974 4049 688 benzathine ben- 4 µM PC3 0 4022 zylpenicillin 4050 661 tiletamine 15 µM HL60 0 3137 4051 642 vincamine 11 µM MCF7 0 2327 4052 623 ambroxol 10 µM HL60 0 1623 4053 1027 orlistat 10 µM PC3 0 6420 4054 641 acepromazine 9 µM HL60 0 1777 4055 629 naproxen 17 µM HL60 0 1869 4056 1086 BCB000038 10 µM MCF7 0 7516 4057 18 celecoxib 10 µM MCF7 0 252 4058 733 sulfamonomethoxine 14 µM PC3 0 5843 4059 761 Prestwick-972 23 µM PC3 0 7266 4060 1065 PHA-00846566E 10 µM PC3 0 7046 4061 622 mepyramine 10 µM HL60 0 1568 4062 71 troglitazone 10 µM SKMEL5 0 504 4063 764 chlortalidone 12 µM PC3 0 7152 4064 761 naftiﬁne 12 µM PC3 0 7273 4065 752 metoprolol 6 µM MCF7 0 6106 4066 1095 vinblastine 100 nM PC3 0 7556 4067 644 hydroxyachillin 14 µM HL60 0 2157 4068 692 gabexate 10 µM PC3 0 4220 4069 640 sulfasalazine 10 µM HL60 0 1733 4070 651 iopromide 5 µM HL60 0 2739 4071 771 minocycline 8 µM MCF7 0 7436 4072 618 vincamine 11 µM HL60 0 2367 4073 53 thioridazine 1 µM MCF7 0 422 4074 764 carbinoxamine 10 µM PC3 0 7138 4075 1087 IC-86621 1 µM PC3 0 7518 4076 658 lasalocid 7 µM HL60 0 3021 4077 663 Prestwick-691 14 µM MCF7 0 2813 4078 690 pheniramine 11 µM MCF7 0 4130 4079 629 isoxicam 12 µM HL60 0 1862 4080 623 betaxolol 12 µM HL60 0 1592 4081 761 pergolide 10 µM PC3 0 7271 4082 747 ketotifen 9 µM MCF7 0 7199 4083 628 diphenhydramine 14 µM PC3 0 1830 4084 628 adiphenine 11 µM PC3 0 1831

105 4085 733 pyridoxine 19 µM PC3 0 5813 4086 767 estradiol 100 nM MCF7 0 6928 4087 660 dexibuprofen 19 µM HL60 0 3094 4088 671 iopamidol 5 µM MCF7 0 3473 4089 627 dapsone 16 µM MCF7 0 1705 4090 634 cefotiam 7 µM HL60 0 2458 4091 761 enalapril 8 µM PC3 0 7265 4092 73 SC-58125 10 µM SKMEL5 0 507 4093 733 hecogenin 9 µM PC3 0 5818 4094 764 mebeverine 9 µM PC3 0 7147 4095 761 laudanosine 11 µM PC3 0 7270 4096 641 convolamine 12 µM HL60 0 1779 4097 691 Prestwick-691 14 µM MCF7 0 4172 4098 70 copper sulfate 100 µM ssMCF7 0 500 4099 618 ﬂudrocortisone 9 µM HL60 0 2368 4100 664 cyclopenthiazide 11 µM HL60 0 2905 4101 627 naproxen 17 µM MCF7 0 1706 4102 504 tretinoin 1 µM MCF7 0 849 4103 664 Prestwick-984 9 µM HL60 0 2903 4104 733 kaempferol 14 µM PC3 0 5839 4105 631 carteolol 12 µM HL60 0 1340 4106 683 lycorine 12 µM PC3 0 3808 4107 629 adiphenine 11 µM HL60 0 1872 4108 649 calcium folinate 8 µM HL60 0 2579 4109 719 carbamazepine 17 µM PC3 0 5093 4110 628 hydroﬂumethiazide 12 µM PC3 0 1809 4111 71 sodium phenylbu- 200 µM SKMEL5 0 502 tyrate 4112 631 cefotetan 7 µM HL60 0 1319 4113 640 molsidomine 17 µM HL60 0 1711 4114 610 troleandomycin 5 µM PC3 0 1885 4115 705 lidocaine 15 µM MCF7 0 4421 4116 618 nalidixic acid 15 µM HL60 0 2336 4117 610 amprolium 13 µM PC3 0 1898 4118 648 streptozocin 15 µM HL60 0 2535 4119 747 isoniazid 29 µM MCF7 0 7197 4120 629 diphenhydramine 14 µM HL60 0 1871 4121 96 MK-886 1 µM MCF7 0 601 4122 1015 PF-00539745-00 10 µM PC3 0 5979 4123 602 fulvestrant 10 nM HL60 0 1179 4124 611 dehydrocholic acid 10 µM PC3 0 1940

106 4125 681 karakoline 11 µM PC3 0 3741 4126 615 hydrastinine 16 µM HL60 0 1436 4127 623 enoxacin 12 µM HL60 0 1597 4128 691 tenoxicam 12 µM MCF7 0 4182 4129 704 vancomycin 3 µM PC3 0 4598 4130 761 azapropazone 13 µM PC3 0 7277 4131 618 griseofulvin 11 µM HL60 0 2332 4132 610 metronidazole 23 µM PC3 0 1921 4133 729 naftidrofuryl 8 µM MCF7 0 5287 4134 749 mephenytoin 18 µM HL60 0 6158 4135 702 ﬂecainide 8 µM PC3 0 4318 4136 659 diloxanide 12 µM HL60 0 3062 4137 659 hymecromone 23 µM HL60 0 3045 4138 659 eticlopride 11 µM HL60 0 3056 4139 764 aconitine 6 µM PC3 0 7149 4140 612 phenazone 21 µM HL60 0 1989 4141 613 glipizide 9 µM HL60 0 2008 4142 513 valproic acid 500 µM MCF7 0 1078 4143 640 ceftazidime 6 µM HL60 0 1721 4144 641 trichostatin A 100 nM HL60 0 1785 4145 37 rosiglitazone 10 µM HL60 0 369 4146 66 imatinib 10 µM PC3 0 483 4147 628 dapsone 16 µM PC3 0 1827 4148 38 estradiol 10 nM ssMCF7 0 373 4149 613 guanabenz 14 µM HL60 0 2045 4150 513 haloperidol 10 µM MCF7 0 1082 4151 644 boldine 12 µM HL60 0 2148 4152 627 homatropine 11 µM MCF7 0 1684 4153 38 dexamethasone 1 µM ssMCF7 0 374 4154 611 josamycin 5 µM PC3 0 1950 4155 729 diclofenamide 13 µM MCF7 0 5286 4156 613 aciclovir 18 µM HL60 0 2044 4157 602 valproic acid 50 µM HL60 0 1163 4158 614 pindolol 16 µM HL60 0 1392 4159 613 haloperidol 11 µM HL60 0 2039 4160 729 mimosine 20 µM MCF7 0 5302 4161 658 carbenoxolone 7 µM HL60 0 3014 4162 628 metformin 24 µM PC3 0 1816 4163 1062 fulvestrant 1 µM PC3 0 6918 4164 66 celecoxib 10 µM PC3 0 482 4165 631 lactobionic acid 11 µM HL60 0 1309

107 4166 612 khellin 15 µM HL60 0 2004 4167 665 viomycin 5 µM HL60 0 2979 4168 54 staurosporine 10 nM MCF7 0 425 4169 610 sulpiride 12 µM PC3 0 1887 4170 631 mebhydrolin 5 µM HL60 0 1333 4171 38 raloxifene 100 nM ssMCF7 0 376 4172 22a ﬂudrocortisone 1 µM MCF7 0 282 4173 628 isoﬂupredone 10 µM PC3 0 1832 4174 614 tranexamic acid 25 µM HL60 0 1401 4175 631 chlorogenic acid 11 µM HL60 0 1346 4176 622 oxybutynin 10 µM HL60 0 1551 4177 764 naproxen 16 µM PC3 0 7146 4178 614 ivermectin 5 µM HL60 0 1367 4179 622 diperodon 9 µM HL60 0 1575 4180 1095 CP-863187 10 µM PC3 0 7558 4181 658 iodixanol 3 µM HL60 0 3023 4182 623 hemicholinium 7 µM HL60 0 1601 4183 610 sulfathiazole 16 µM PC3 0 1883 4184 614 thioproperazine 6 µM HL60 0 1390 4185 613 methotrexate 9 µM HL60 0 2041 4186 513 estradiol 10 nM MCF7 0 1079 4187 513 genistein 10 µM MCF7 0 1073 4188 628 sulfaphenazole 13 µM PC3 0 1794 4189 611 diltiazem 9 µM PC3 0 1948 4190 1038 PNU-0293363 10 µM PC3 0 6563 4191 610 hydrochlorothiazide 13 µM PC3 0 1906 4192 628 meticrane 15 µM PC3 0 1792 4193 611 lynestrenol 14 µM PC3 0 1953 4194 611 edrophonium chlo- 20 µM PC3 0 1936 ride 4195 611 lisuride 12 µM PC3 0 1962 4196 612 4- 20 µM HL60 0 1997 hydroxyphenazone 4197 612 ethambutol 14 µM HL60 0 1981 4198 611 oleandomycin 5 µM PC3 0 1935 4199 1077 fulvestrant 1 µM PC3 0 7096 4200 622 chlortalidone 12 µM HL60 0 1581 4201 612 miconazole 10 µM HL60 0 1977 4202 28 diclofenac 10 µM MCF7 0 333 4203 612 ticlopidine 13 µM HL60 0 1975 4204 611 hesperetin 13 µM PC3 0 1947 4205 628 allantoin 25 µM PC3 0 1800

108 4206 612 pyrimethamine 16 µM HL60 0 1974 4207 630 pentoxyverine 8 µM HL60 0 1268 4208 615 etodolac 14 µM HL60 0 1407 4209 612 levodopa 20 µM HL60 0 1972 4210 41 wortmannin 10 nM HL60 0 389 4211 622 tremorine 15 µM HL60 0 1579 4212 613 midecamycin 5 µM HL60 0 2026 4213 29 felodipine 10 µM MCF7 0 337 4214 613 apomorphine 6 µM HL60 0 2005 4215 614 picotamide 10 µM HL60 0 1387 4216 628 sulindac 11 µM PC3 0 1815 4217 689 ticlopidine 13 µM PC3 0 4074 4218 640 etamivan 18 µM HL60 0 1730 4219 614 nalbuphine 10 µM HL60 0 1379 4220 610 captopril 17 µM PC3 0 1907 4221 641 cinchonidine 14 µM HL60 0 1780 4222 765 valproic acid 1 mM MCF7 0 6969 4223 614 gallamine triethio- 4 µM HL60 0 1375 dide 4224 612 prednisone 11 µM HL60 0 1978 4225 615 pyrantel 11 µM HL60 0 1413 4226 623 ascorbic acid 22 µM HL60 0 1610 4227 613 edrophonium chlo- 20 µM HL60 0 2019 ride 4228 610 tolazoline 20 µM PC3 0 1918 4229 5 estradiol 10 nM MCF7 0 121 4230 761 chloroquine 8 µM PC3 0 7251 4231 630 trichostatin A 100 nM HL60 0 1284 4232 622 sulfinpyrazone 10 µM HL60 0 1574 4233 659 capsaicin 13 µM HL60 0 3034 4234 703 paroxetine 1 µM PC3 0 4556 4235 109 novobiocin 100 µM SKMEL5 0 632 4236 729 tacrine 16 µM MCF7 0 5297 4237 630 flupentixol 8 µM HL60 0 1288 4238 103 monastrol 20 µM MCF7 0 614 4239 630 oxantel 7 µM HL60 0 1277 4240 622 bambuterol 10 µM HL60 0 1582 4241 747 ticarcillin 9 µM MCF7 0 7185 4242 745 fluorocurarine 12 µM MCF7 0 6219 4243 616 neomycin 4 µM PC3 0 2066 4244 610 diphemanil metil- 10 µM PC3 0 1912 sulfate

109 4245 55 troglitazone 10 µM PC3 0 431 4246 641 hydrocotarnine 13 µM HL60 0 1772 4247 69 monorden 100 nM SKMEL5 0 493 4248 631 apigenin 15 µM HL60 0 1321 4249 613 ampicillin 10 µM HL60 0 2030 4250 109 benserazide 10 µM SKMEL5 0 631 4251 617 piroxicam 12 µM PC3 0 2089 4252 734 harmine 16 µM PC3 0 5855 4253 630 amoxicillin 11 µM HL60 0 1265 4254 1038 STOCK1N-35696 15 µM PC3 0 6564 4255 701 ﬂunixin 8 µM PC3 0 4273 4256 630 bisoprolol 9 µM HL60 0 1287 4257 610 hexamethonium 10 µM PC3 0 1901 bromide 4258 641 dacarbazine 22 µM HL60 0 1762 4259 1050 BAS-012416453 38 µM PC3 0 6876 4260 611 haloperidol 11 µM PC3 0 1955 4261 612 minoxidil 19 µM HL60 0 1996 4262 628 chloramphenicol 12 µM PC3 0 1795 4263 648 etanidazole 19 µM HL60 0 2510 4264 640 trichostatin A 100 nM HL60 0 1732 4265 659 phthalylsulfathiazole 10 µM HL60 0 3033 4266 658 fosfosal 18 µM HL60 0 2997 4267 615 cloxacillin 9 µM HL60 0 1443 4268 751 Prestwick-665 12 µM MCF7 0 6041 4269 761 asiaticoside 4 µM PC3 0 7244 4270 713 phthalylsulfathiazole 10 µM PC3 0 4653 4271 714 amikacin 7 µM PC3 0 6715 4272 61 indometacin 100 µM PC3 0 452 4273 602 valproic acid 500 µM HL60 0 1181 4274 611 hydroxyzine 9 µM PC3 0 1941 4275 658 beclometasone 8 µM HL60 0 3001 4276 612 hydrochlorothiazide 13 µM HL60 0 1987 4277 614 nomifensine 11 µM HL60 0 1378 4278 1061 SC-560 10 µM MCF7 0 6913 4279 613 dehydrocholic acid 10 µM HL60 0 2023 4280 58 novobiocin 100 µM MCF7 0 437 4281 712 terguride 9 µM PC3 0 4633 4282 680 sulfamethoxazole 16 µM PC3 0 3667 4283 94 3-aminobenzamide 10 mM MCF7 0 590 4284 659 ioversol 5 µM HL60 0 3026

110 4285 714 ambroxol 10 µM PC3 0 6719 4286 614 acenocoumarol 11 µM HL60 0 1394 4287 629 benzonatate 7 µM HL60 0 1843 4288 714 dexibuprofen 19 µM PC3 0 6712 4289 648 naproxen 16 µM HL60 0 2533 4290 16 rofecoxib 10 µM MCF7 0 205 4291 614 neomycin 4 µM HL60 0 1383 4292 623 amikacin 7 µM HL60 0 1618 4293 26b arachidonyltrifluoromethane10 µM MCF7 0 327 4294 651 pyrithyldione 24 µM HL60 0 2740 4295 13 nordihydroguaiaretic 1 µM MCF7 0 203 acid 4296 651 ribostamycin 7 µM HL60 0 2705 4297 648 cefalotin 10 µM HL60 0 2517 4298 623 phenylpropanolamine 21 µM HL60 0 1602 4299 762 lansoprazole 11 µM PC3 0 7306 4300 659 esculin 12 µM HL60 0 3052 4301 612 amiloride 13 µM HL60 0 1970 4302 730 erythromycin 5 µM MCF7 0 5329 4303 616 dizocilpine 12 µM PC3 0 2069 4304 616 pirenzepine 9 µM PC3 0 2071 4305 659 digoxigenin 10 µM HL60 0 3060 4306 714 paclitaxel 5 µM PC3 0 6720 4307 658 trichlormethiazide 11 µM HL60 0 2998 4308 658 Prestwick-857 12 µM HL60 0 3016 4309 714 urapidil 9 µM PC3 0 6696 4310 750 fulvestrant 1 µM HL60 0 6165 4311 1059 BAS-012416453 38 µM MCF7 0 6908 4312 761 alfadolone 10 µM PC3 0 7262 4313 654 N-acetyl-L-aspartic 23 µM MCF7 0 3265 acid 4314 727 LY-294002 100 nM PC3 0 4440 4315 761 ursodeoxycholic 10 µM PC3 0 7243 acid 4316 612 oxybuprocaine 12 µM HL60 0 1976 4317 616 nalbuphine 10 µM PC3 0 2063 4318 612 diflunisal 16 µM HL60 0 1990 4319 628 mefenamic acid 17 µM PC3 0 1821 4320 659 diclofenamide 13 µM HL60 0 3027 4321 709 retrorsine 11 µM PC3 0 6601 4322 623 brinzolamide 10 µM HL60 0 1615 4323 745 ciprofibrate 14 µM MCF7 0 6218

111 4324 603 alvespimycin 100 nM PC3 0 1213 4325 630 coralyne 10 µM HL60 0 1298 4326 98 NU-1025 100 µM MCF7 0 608 4327 750 rosiglitazone 10 µM HL60 0 6192 4328 715 fusidic acid 7 µM PC3 0 6754 4329 701 meclofenoxate 14 µM PC3 0 4268 4330 641 riboflavin 11 µM HL60 0 1767 4331 17 tanespimycin 100 nM MCF7 0 221 4332 771 disopyramide 12 µM MCF7 0 7439 4333 602 LY-294002 100 nM HL60 0 1157 4334 665 torasemide 11 µM HL60 0 2956 4335 714 biotin 16 µM PC3 0 6689 4336 648 napelline 11 µM HL60 0 2522 4337 630 thioguanosine 13 µM HL60 0 1264 4338 110b genistein 10 µM PC3 0 703 4339 631 trichostatin A 100 nM HL60 0 1306 4340 1076 0316684-0000 10 µM MCF7 0 7093 4341 745 tetrahydroalstonine 11 µM MCF7 0 6209 4342 617 pyrantel 11 µM PC3 0 2097 4343 616 naltrexone 10 µM PC3 0 2047 4344 627 morantel 11 µM MCF7 0 1676 4345 738 thiocolchicoside 7 µM MCF7 0 5520 4346 665 ioxaglic acid 3 µM HL60 0 2966 4347 55 tanespimycin 1 µM PC3 0 432 4348 734 bambuterol 10 µM PC3 0 5885 4349 713 butyl hydroxyben- 21 µM PC3 0 4647 zoate 4350 714 flucytosine 31 µM PC3 0 6690 4351 715 nilutamide 13 µM PC3 0 6763 4352 651 azlocillin 8 µM HL60 0 2727 4353 650 tanespimycin 1 µM HL60 0 2685 4354 749 ticarcillin 9 µM HL60 0 6146 4355 745 sulfinpyrazone 10 µM MCF7 0 6230 4356 734 delsoline 9 µM PC3 0 5858 4357 688 mycophenolic acid 12 µM PC3 0 4019 4358 630 testosterone 12 µM HL60 0 1295 4359 712 metyrapone 18 µM PC3 0 4606 4360 39 tamoxifen 1 µM MCF7 0 380 4361 702 benfotiamine 9 µM PC3 0 4312 4362 626 LY-294002 100 nM MCF7 0 1641 4363 702 famprofazone 11 µM PC3 0 4309

112 4364 640 trimetazidine 12 µM HL60 0 1727 4365 695 carcinine 22 µM MCF7 0 4809 4366 650 alvespimycin 100 nM HL60 0 2673 4367 750 alvespimycin 100 nM HL60 0 6172 4368 1057 orlistat 10 µM MCF7 0 6905 4369 681 meclofenoxate 14 µM PC3 0 3707 4370 649 cloperastine 11 µM HL60 0 2549 4371 635 methoxamine 16 µM HL60 0 2488 4372 661 adrenosterone 13 µM HL60 0 3107 4373 694 tolnaftate 13 µM MCF7 0 4805 4374 660 cantharidin 20 µM HL60 0 3075 4375 660 pipemidic acid 13 µM HL60 0 3093 4376 720 2,6- 27 µM MCF7 0 4363 dimethylpiperidine 4377 505 5149715 10 µM MCF7 0 890 4378 737 flufenamic acid 14 µM MCF7 0 5478 4379 1040 PNU-0293363 10 µM PC3 0 6568 4380 648 kinetin 19 µM HL60 0 2511 4381 1062 AG-012559 10 µM PC3 0 6920 4382 618 orphenadrine 13 µM HL60 0 2356 4383 36 estradiol 100 nM MCF7 0 365 4384 757 LY-294002 100 nM MCF7 0 5576 4385 602 alpha-estradiol 10 nM HL60 0 1151 4386 704 captopril 17 µM PC3 0 4585 4387 657 budesonide 9 µM MCF7 0 2866 4388 661 deptropine 8 µM HL60 0 3144 4389 648 skimmianine 15 µM HL60 0 2504 4390 694 colistin 3 µM MCF7 0 4796 4391 661 isradipine 11 µM HL60 0 3129 4392 658 etidronic acid 16 µM HL60 0 2985 4393 741 meticrane 15 µM MCF7 0 5984 4394 706 carisoprodol 15 µM MCF7 0 4955 4395 630 bezafibrate 11 µM HL60 0 1275 4396 1057 AH-23848 1 µM MCF7 0 6903 4397 659 bemegride 26 µM HL60 0 3051 4398 86 fisetin 50 µM PC3 0 579 4399 602 alvespimycin 100 nM HL60 0 1154 4400 629 allantoin 25 µM HL60 0 1842 4401 762 thalidomide 15 µM PC3 0 7288 4402 695 corynanthine 10 µM MCF7 0 4811 4403 651 sulfametoxydiazine 14 µM HL60 0 2712

113 4404 631 brompheniramine 9 µM HL60 0 1335 4405 657 laudanosine 11 µM MCF7 0 2890 4406 714 primidone 18 µM PC3 0 6723 4407 664 gibberellic acid 12 µM HL60 0 2910 4408 635 trichostatin A 100 nM HL60 0 2474 4409 618 mephenesin 22 µM HL60 0 2342 4410 617 etodolac 14 µM PC3 0 2091 4411 615 nifenazone 13 µM HL60 0 1439 4412 659 fluvastatin 9 µM HL60 0 3032 4413 664 memantine 19 µM HL60 0 2934 4414 1069 SC-19220 10 µM PC3 0 7065 4415 659 xamoterol 5 µM HL60 0 3064 4416 734 sulfadoxine 13 µM PC3 0 5852 4417 660 meglumine 20 µM HL60 0 3068 4418 1017 3-nitropropionic 10 µM PC3 0 6372 acid 4419 750 LY-294002 100 nM HL60 0 6175 4420 664 molindone 13 µM HL60 0 2917 4421 649 levonorgestrel 13 µM HL60 0 2547 4422 659 doxazosin 7 µM HL60 0 3024 4423 685 0179445-0000 1 µM MCF7 0 3633 4424 74 tanespimycin 1 µM ssMCF7 0 521 4425 87 dimethyloxalylglycine 1 mM PC3 0 584 4426 650 geldanamycin 1 µM HL60 0 2688 4427 750 vorinostat 10 µM HL60 0 6179 4428 761 mesoridazine 7 µM PC3 0 7256 4429 629 sulfaphenazole 13 µM HL60 0 1836 4430 1024 3-nitropropionic 10 µM MCF7 0 6402 acid 4431 40 tanespimycin 1 µM MCF7 0 381 4432 646 mepyramine 10 µM MCF7 0 3184 4433 665 etomidate 16 µM HL60 0 2958 4434 659 sulconazole 9 µM HL60 0 3035 4435 664 fluvoxamine 9 µM HL60 0 2913 4436 1059 SB-202190 1 µM MCF7 0 6909 4437 648 trioxysalen 18 µM HL60 0 2516 4438 692 tolnaftate 13 µM PC3 0 4221 4439 645 Prestwick-665 12 µM HL60 0 2186 4440 627 dexpanthenol 19 µM MCF7 0 1680 4441 648 fluorocurarine 12 µM HL60 0 2521 4442 689 cefsulodin 7 µM PC3 0 4067 4443 702 solasodine 10 µM PC3 0 4305

114 4444 641 epivincamine 11 µM HL60 0 1783 4445 1078 6-bromoindirubin- 500 nM MCF7 0 7101 3’-oxime 4446 618 nefopam 14 µM HL60 0 2355 4447 704 apigenin 15 µM PC3 0 4578 4448 682 acacetin 14 µM PC3 0 3767 4449 622 streptomycin 3 µM HL60 0 1578 4450 682 citiolone 25 µM PC3 0 3755 4451 645 myosmine 27 µM HL60 0 2199 4452 703 homosalate 15 µM PC3 0 4533 4453 713 lorglumide 8 µM PC3 0 4658 4454 681 Prestwick-664 8 µM PC3 0 3715 4455 645 metamizole sodium 12 µM HL60 0 2175 4456 611 guanabenz 14 µM PC3 0 1961 4457 708 dehydrocholic acid 10 µM MCF7 0 5681 4458 658 chloropyramine 12 µM HL60 0 3011 4459 664 sitosterol 10 µM HL60 0 2912 4460 702 dicoumarol 12 µM PC3 0 4323 4461 623 chlormezanone 15 µM HL60 0 1620 4462 701 bromopride 12 µM PC3 0 4278 4463 634 bisacodyl 11 µM HL60 0 2435 4464 671 hecogenin 9 µM MCF7 0 3457 4465 664 decamethonium 10 µM HL60 0 2933 bromide 4466 761 thiamphenicol 11 µM PC3 0 7274 4467 635 L-methionine 22 µM HL60 0 2470 sulfoximine 4468 634 felodipine 10 µM HL60 0 2433 4469 506 LY-294002 100 nM MCF7 0 996 4470 1090 11-deoxy-16,16- 10 µM MCF7 0 7533 dimethylprostaglandin E2 4471 689 metrizamide 5 µM PC3 0 4075 4472 715 idazoxan 17 µM PC3 0 6747 4473 728 zomepirac 13 µM PC3 0 4479 4474 630 guanfacine 14 µM HL60 0 1279 4475 693 salsolinol 15 µM PC3 0 4232 4476 693 cetirizine 9 µM PC3 0 4231 4477 659 nicotinic acid 32 µM HL60 0 3043 4478 660 pralidoxime 23 µM HL60 0 3066 4479 682 furaltadone 11 µM PC3 0 3756 4480 749 estriol 14 µM HL60 0 6140 4481 701 heliotrine 13 µM PC3 0 4277

115 4482 664 naftopidil 9 µM HL60 0 2911 4483 616 gallamine triethio- 4 µM PC3 0 2059 dide 4484 651 securinine 18 µM HL60 0 2729 4485 23 sulindac sulfide 50 µM MCF7 0 308 4486 758 lorglumide 8 µM MCF7 0 5619 4487 712 hymecromone 23 µM PC3 0 4623 4488 627 heptaminol 22 µM MCF7 0 1703 4489 656 cefaclor 10 µM MCF7 0 2843 4490 750 acetylsalicylic acid 100 µM HL60 0 6164 4491 1055 NS-398 10 µM MCF7 0 6897 4492 619 flunarizine 8 µM HL60 0 2381 4493 1071 AR-A014418 10 µM PC3 0 7070 4494 74 nordihydroguaiaretic 1 µM ssMCF7 0 524 acid 4495 23 fulvestrant 10 nM MCF7 0 310 4496 628 benzonatate 7 µM PC3 0 1801 4497 659 crotamiton 20 µM HL60 0 3050 4498 645 bromopride 12 µM HL60 0 2182 4499 713 latamoxef 7 µM PC3 0 4648 4500 701 Prestwick-674 14 µM PC3 0 4276 4501 703 Prestwick-1100 9 µM PC3 0 4534 4502 610 pheniramine 11 µM PC3 0 1910 4503 694 sulfathiazole 16 µM MCF7 0 4769 4504 682 piperacillin 7 µM PC3 0 3763 4505 681 sulfamerazine 15 µM PC3 0 3718 4506 634 dicloxacillin 8 µM HL60 0 2445 4507 615 flumequine 15 µM HL60 0 1429 4508 6 tolbutamide 100 µM MCF7 0 142 4509 649 guaifenesin 20 µM HL60 0 2569 4510 603 tanespimycin 1 µM PC3 0 1206 4511 614 tamoxifen 7 µM HL60 0 1366 4512 1081 BCB000040 10 µM PC3 0 7493 4513 712 Prestwick-860 35 µM PC3 0 4618 4514 514 phenanthridinone 51 µM MCF7 0 1115 4515 710 brinzolamide 10 µM PC3 0 6670 4516 662 ipratropium bro- 10 µM MCF7 0 2762 mide 4517 689 cimetidine 16 µM PC3 0 4063 4518 688 pronetalol 15 µM PC3 0 3984 4519 663 harmaline 14 µM MCF7 0 2805 4520 681 PNU-0230031 1 µM PC3 0 3735

116 4521 682 solasodine 10 µM PC3 0 3749 4522 713 enoxacin 12 µM PC3 0 4655 4523 728 pindolol 16 µM PC3 0 4496 4524 664 etofenamate 11 µM HL60 0 2907 4525 664 harpagoside 8 µM HL60 0 2935 4526 731 etanidazole 19 µM PC3 0 5730 4527 654 ginkgolide A 10 µM MCF7 0 3260 4528 754 molsidomine 17 µM PC3 0 6325 4529 733 suxibuzone 9 µM PC3 0 5806 4530 702 metamizole sodium 12 µM PC3 0 4310 4531 629 chloramphenicol 12 µM HL60 0 1837 4532 758 cotinine 23 µM MCF7 0 5611 4533 748 vidarabine 15 µM MCF7 0 7203 4534 714 benserazide 14 µM PC3 0 6722 4535 634 digoxin 5 µM HL60 0 2423 4536 660 dioxybenzone 16 µM HL60 0 3101 4537 1026 orlistat 10 µM MCF7 0 6415 4538 635 cetirizine 9 µM HL60 0 2468 4539 689 moxonidine 17 µM PC3 0 4084 4540 657 thiocolchicoside 7 µM MCF7 0 2875 4541 692 diﬂunisal 16 µM PC3 0 4210 4542 756 atropine methoni- 11 µM MCF7 0 6495 trate 4543 730 ceforanide 8 µM MCF7 0 5351 4544 698 nalidixic acid 15 µM PC3 0 7367 4545 612 sulpiride 12 µM HL60 0 1967 4546 664 epitiostanol 13 µM HL60 0 2922 4547 630 ketoconazole 8 µM HL60 0 1285 4548 728 atropine oxide 12 µM PC3 0 4476 4549 664 Prestwick-967 26 µM HL60 0 2925 4550 660 rolipram 15 µM HL60 0 3072 4551 618 mexiletine 19 µM HL60 0 2364 4552 661 nipecotic acid 31 µM HL60 0 3121 4553 659 ganciclovir 16 µM HL60 0 3030 4554 616 spironolactone 10 µM PC3 0 2064 4555 703 nialamide 13 µM PC3 0 4525 4556 772 triﬂusal 16 µM MCF7 0 7451 4557 745 chloropyrazine 35 µM MCF7 0 6227 4558 658 novobiocin 6 µM HL60 0 2990 4559 657 gliclazide 12 µM MCF7 0 2870 4560 1024 PF-01378883-00 10 µM MCF7 0 6405

117 4561 54 iloprost 1 µM MCF7 0 427 4562 656 pyrazinamide 32 µM MCF7 0 2839 4563 711 ﬂunisolide 9 µM MCF7 0 3923 4564 708 niridazole 19 µM MCF7 0 5682 4565 615 oxolinic acid 15 µM HL60 0 1419 4566 39 tacrolimus 1 µM MCF7 0 378 4567 709 apramycin 7 µM PC3 0 6614 4568 755 (-)-atenolol 15 µM MCF7 0 6444 4569 16 SC-58125 10 µM MCF7 0 208 4570 719 telenzepine 9 µM PC3 0 5096 4571 672 cefsulodin 7 µM MCF7 0 3328 4572 645 promazine 12 µM HL60 0 2173 4573 662 atropine 6 µM MCF7 0 2761 4574 664 proscillaridin 8 µM HL60 0 2920 4575 654 dl-alpha tocopherol 9 µM MCF7 0 3256 4576 707 luteolin 14 µM MCF7 0 5004 4577 709 benzthiazide 9 µM PC3 0 6607 4578 713 alfuzosin 9 µM PC3 0 4644 4579 728 benzylpenicillin 11 µM PC3 0 4501 4580 757 valproic acid 50 µM MCF7 0 5582 4581 687 CP-320650-01 1 µM MCF7 0 3908 4582 670 cefamandole 8 µM MCF7 0 3436 4583 629 trichostatin A 100 nM HL60 0 1835 4584 650 alpha-estradiol 10 nM HL60 0 2670 4585 649 fenoprofen 7 µM HL60 0 2553 4586 659 Prestwick-860 35 µM HL60 0 3040 4587 603 monorden 100 nM PC3 0 1219 4588 712 altretamine 19 µM PC3 0 4627 4589 700 fenoprofen 7 µM MCF7 0 4736 4590 44 tetraethylenepentamine100 µM HL60 0 412 4591 720 oxaprozin 14 µM MCF7 0 4352 4592 709 Prestwick-984 9 µM PC3 0 6603 4593 1086 IC-86621 1 µM MCF7 0 7513 4594 96 arachidonic acid 10 µM MCF7 0 604 4595 641 stachydrine 22 µM HL60 0 1751 4596 627 allantoin 25 µM MCF7 0 1678 4597 711 furaltadone 11 µM MCF7 0 3932 4598 704 ceﬁxime 9 µM PC3 0 4567 4599 678 Prestwick-1084 16 µM MCF7 0 3546 4600 689 sitosterol 10 µM PC3 0 4073 4601 629 morantel 11 µM HL60 0 1840

118 4602 695 theophylline 20 µM MCF7 0 4812 4603 701 fenbufen 16 µM PC3 0 4279 4604 680 cefazolin 8 µM PC3 0 3686 4605 635 pyrazinamide 32 µM HL60 0 2478 4606 751 mepenzolate bro- 10 µM MCF7 0 6024 mide 4607 660 trichostatin A 100 nM HL60 0 3077 4608 709 hexamethonium 10 µM PC3 0 6620 bromide 4609 671 pridinol 10 µM MCF7 0 3456 4610 1005 fulvestrant 1 µM PC3 0 5931 4611 650 acetylsalicylic acid 100 µM HL60 0 2664 4612 765 estradiol 100 nM MCF7 0 6968 4613 733 streptomycin 3 µM PC3 0 5837 4614 712 tyloxapol 4 µM PC3 0 4611 4615 728 napelline 11 µM PC3 0 4486 4616 709 betahistine 17 µM PC3 0 6611 4617 711 deferoxamine 6 µM MCF7 0 3936 4618 622 mebeverine 9 µM HL60 0 1576 4619 603 geldanamycin 1 µM PC3 0 1228 4620 678 sulfadoxine 13 µM MCF7 0 3547 4621 658 simvastatin 10 µM HL60 0 3002 4622 727 chlorpromazine 1 µM PC3 0 4441 4623 732 hexylcaine 13 µM PC3 0 5768 4624 704 piromidic acid 14 µM PC3 0 4575 4625 693 carcinine 22 µM PC3 0 4225 4626 701 foliosidine 13 µM PC3 0 4295 4627 39 celecoxib 10 µM MCF7 0 377 4628 1024 valdecoxib 10 µM MCF7 0 6403 4629 676 memantine 19 µM MCF7 0 7354 4630 630 dequalinium chlo- 8 µM HL60 0 1276 ride 4631 649 meclofenoxate 14 µM HL60 0 2546 4632 648 butirosin 5 µM HL60 0 2518 4633 649 sulfamethoxypyridazine14 µM HL60 0 2550 4634 651 pridinol 10 µM HL60 0 2715 4635 650 sirolimus 100 nM HL60 0 2667 4636 694 hydroxyachillin 14 µM MCF7 0 4797 4637 756 chrysin 16 µM MCF7 0 6485 4638 657 trimetazidine 12 µM MCF7 0 2876 4639 1075 pioglitazone 10 µM PC3 0 7088 4640 730 pilocarpine 15 µM MCF7 0 5341

119 4641 682 eucatropine 12 µM PC3 0 3759 4642 692 zardaverine 15 µM PC3 0 4209 4643 728 hydrocotarnine 13 µM PC3 0 4489 4644 749 natamycin 6 µM HL60 0 6126 4645 701 0179445-0000 1 µM PC3 0 4292 4646 738 lisinopril 9 µM MCF7 0 5504 4647 110b fulvestrant 1 µM PC3 0 704 4648 630 domperidone 7 µM HL60 0 1301 4649 683 ciclacillin 12 µM PC3 0 3800 4650 693 indoprofen 14 µM PC3 0 4249 4651 649 bendroﬂumethiazide 9 µM HL60 0 2555 4652 691 tetroquinone 21 µM MCF7 0 4159 4653 695 minaprine 11 µM MCF7 0 4814 4654 720 parbendazole 16 µM MCF7 0 4357 4655 702 proglumide 12 µM PC3 0 4337 4656 702 spiramycin 5 µM PC3 0 4319 4657 660 lorglumide 8 µM HL60 0 3079 4658 1069 GW-8510 10 µM PC3 0 7067 4659 619 ﬂavoxate 9 µM HL60 0 2373 4660 751 acacetin 14 µM MCF7 0 6044 4661 743 sulfapyridine 16 µM MCF7 0 6799 4662 665 tridihexethyl 11 µM HL60 0 2964 4663 116 butirosin 10 µM PC3 0 666 4664 618 prilocaine 16 µM HL60 0 2352 4665 627 meticrane 15 µM MCF7 0 1671 4666 692 idoxuridine 11 µM PC3 0 4200 4667 635 betahistine 17 µM HL60 0 2472 4668 718 trimetazidine 12 µM PC3 0 5060 4669 16 LM-1685 10 µM MCF7 0 207 4670 700 6- 18 µM MCF7 0 4748 benzylaminopurine 4671 694 scopolamine 12 µM MCF7 0 4803 4672 710 benzbromarone 9 µM PC3 0 6669 4673 714 debrisoquine 9 µM PC3 0 6688 4674 40 tretinoin 1 µM MCF7 0 384 4675 688 6-azathymine 31 µM PC3 0 3987 4676 636 acetylsalicylsalicylic 13 µM MCF7 0 2223 acid 4677 755 tyloxapol 4 µM MCF7 0 6452 4678 90 docosahexaenoic 100 µM PC3 0 664 acid ethyl ester 4679 1054 NS-398 10 µM PC3 0 6892

120 4680 635 cefaclor 10 µM HL60 0 2483 4681 628 homatropine 11 µM PC3 0 1806 4682 710 methapyrilene 13 µM PC3 0 6644 4683 649 dicoumarol 12 µM HL60 0 2561 4684 648 terazosin 9 µM HL60 0 2530 4685 710 (-)-MK-801 12 µM PC3 0 6657 4686 661 azapropazone 13 µM HL60 0 3143 4687 680 griseofulvin 11 µM PC3 0 3664 4688 749 piperidolate 11 µM HL60 0 6129 4689 701 levonorgestrel 13 µM PC3 0 4269 4690 755 desoxycortone 12 µM MCF7 0 6476 4691 21 genistein 1 µM MCF7 0 267 4692 655 melatonin 17 µM MCF7 0 3293 4693 614 acetylsalicylsalicylic 13 µM HL60 0 1377 acid 4694 744 dacarbazine 22 µM MCF7 0 6816 4695 752 skimmianine 15 µM MCF7 0 6066 4696 648 Prestwick-689 10 µM HL60 0 2514 4697 704 etidronic acid 16 µM PC3 0 4564 4698 632 phenazone 21 µM MCF7 0 1489 4699 715 neostigmine bro- 13 µM PC3 0 6735 mide 4700 752 anabasine 25 µM MCF7 0 6074 4701 700 lomeﬂoxacin 10 µM MCF7 0 4745 4702 735 esculin 12 µM MCF7 0 5411 4703 635 omeprazole 12 µM HL60 0 2467 4704 661 proxyphylline 17 µM HL60 0 3115 4705 711 solasodine 10 µM MCF7 0 3924 4706 610 lidocaine 15 µM PC3 0 1917 4707 703 ciclacillin 12 µM PC3 0 4536 4708 714 moroxydine 19 µM PC3 0 6705 4709 94 probucol 10 µM MCF7 0 592 4710 693 cyclopenthiazide 11 µM PC3 0 4229 4711 677 talampicillin 8 µM MCF7 0 3515 4712 727 estradiol 100 nM PC3 0 4432 4713 658 mestranol 13 µM HL60 0 3008 4714 654 apigenin 15 µM MCF7 0 3257 4715 1068 GW-8510 10 µM MCF7 0 7062 4716 630 arecoline 17 µM HL60 0 1303 4717 629 todralazine 15 µM HL60 0 1841 4718 731 ﬁpexide 9 µM PC3 0 5737 4719 661 ketorolac 11 µM HL60 0 3110

121 4720 670 guanadrel 8 µM MCF7 0 3438 4721 634 colecalciferol 10 µM HL60 0 2436 4722 710 ketanserin 7 µM PC3 0 6649 4723 644 retrorsine 11 µM HL60 0 2129 4724 688 pheniramine 11 µM PC3 0 4012 4725 683 Prestwick-1080 15 µM PC3 0 3796 4726 728 altizide 10 µM PC3 0 4491 4727 651 proadifen 10 µM HL60 0 2707 4728 680 nalidixic acid 15 µM PC3 0 3668 4729 709 nifurtimox 14 µM PC3 0 6608 4730 619 prednisolone 11 µM HL60 0 2393 4731 695 amprolium 13 µM MCF7 0 4825 4732 660 desoxycortone 12 µM HL60 0 3099 4733 650 haloperidol 10 µM HL60 0 2663 4734 715 (-)-atenolol 15 µM PC3 0 6725 4735 683 lithocholic acid 11 µM PC3 0 3816 4736 641 ipratropium bro- 10 µM HL60 0 1769 mide 4737 619 lincomycin 9 µM HL60 0 2380 4738 110b alpha-estradiol 10 nM PC3 0 702 4739 691 metrizamide 5 µM MCF7 0 4156 4740 672 trichostatin A 100 nM MCF7 0 3332 4741 749 triﬂuridine 14 µM HL60 0 6136 4742 694 trichlormethiazide 11 µM MCF7 0 4783 4743 751 benfotiamine 9 µM MCF7 0 6032 4744 658 levobunolol 12 µM HL60 0 3015 4745 647 methapyrilene 13 µM MCF7 0 3205 4746 685 tropicamide 14 µM MCF7 0 3619 4747 727 genistein 10 µM PC3 0 4459 4748 732 methanthelinium 10 µM PC3 0 5780 bromide 4749 651 sulfanilamide 23 µM HL60 0 2709 4750 689 4- 20 µM PC3 0 4095 hydroxyphenazone 4751 635 salsolidin 16 µM HL60 0 2463 4752 672 propantheline bro- 9 µM MCF7 0 3352 mide 4753 719 todralazine 15 µM PC3 0 5087 4754 653 guanfacine 14 µM MCF7 0 2634 4755 1023 C-75 10 µM PC3 0 6399 4756 702 sulfachlorpyridazine 14 µM PC3 0 4326 4757 662 ellipticine 16 µM MCF7 0 2758 4758 702 ﬂuocinonide 8 µM PC3 0 4314

122 4759 737 loracarbef 11 µM MCF7 0 5492 4760 757 haloperidol 10 µM MCF7 0 5563 4761 650 LY-294002 10 µM HL60 0 2687 4762 664 fursultiamine 9 µM HL60 0 2929 4763 662 calycanthine 12 µM MCF7 0 2764 4764 626 tanespimycin 1 µM MCF7 0 1650 4765 1078 0198306-0000 10 µM MCF7 0 7099 4766 736 dimenhydrinate 9 µM MCF7 0 5450 4767 1088 pioglitazone 10 µM MCF7 0 7523 4768 708 androsterone 14 µM MCF7 0 5696 4769 750 haloperidol 10 µM HL60 0 6163 4770 634 pilocarpine 15 µM HL60 0 2438 4771 632 hydrochlorothiazide 13 µM MCF7 0 1487 4772 705 ceﬁxime 9 µM MCF7 0 4390 4773 685 sulfamerazine 15 µM MCF7 0 3616 4774 711 PHA-00851261E 1 µM MCF7 0 3968 4775 1046 16,16- 10 µM PC3 0 6592 dimethylprostaglandin E2 4776 698 sulfamethoxazole 16 µM PC3 0 7366 4777 718 adrenosterone 13 µM PC3 0 5045 4778 63 copper sulfate 100 µM PC3 0 459 4779 1054 SB-203580 1 µM PC3 0 6894 4780 680 glycopyrronium 10 µM PC3 0 3687 bromide 4781 701 metoclopramide 12 µM PC3 0 4285 4782 635 probenecid 14 µM HL60 0 2464 4783 677 piribedil 12 µM MCF7 0 3512 4784 689 sotalol 13 µM PC3 0 4079 4785 737 levopropoxyphene 7 µM MCF7 0 5503 4786 712 dimethadione 31 µM PC3 0 4607 4787 750 chlorpromazine 1 µM HL60 0 6176 4788 743 chlorphenamine 10 µM MCF7 0 6773 4789 664 apramycin 7 µM HL60 0 2914 4790 692 trimethylcolchicinic 12 µM PC3 0 4202 acid 4791 715 chlortetracycline 8 µM PC3 0 6761 4792 691 carbenoxolone 7 µM MCF7 0 4173 4793 749 piperacetazine 10 µM HL60 0 6152 4794 694 benzocaine 24 µM MCF7 0 4808 4795 690 ethambutol 14 µM MCF7 0 4120 4796 726 sulfafurazole 15 µM MCF7 0 5257

123 4797 680 PNU-0251126 1 µM PC3 0 3692 4798 691 sitosterol 10 µM MCF7 0 4154 4799 731 dihydrostreptomycin 3 µM PC3 0 5751 4800 689 cefadroxil 11 µM PC3 0 4080 4801 662 hydroquinine 9 µM MCF7 0 2767 4802 728 riboﬂavin 11 µM PC3 0 4485 4803 645 citiolone 25 µM HL60 0 2176 4804 699 0175029-0000 1 µM MCF7 0 4716 4805 657 piracetam 28 µM MCF7 0 2861 4806 659 aminophylline 10 µM HL60 0 3036 4807 659 rolitetracycline 8 µM HL60 0 3031 4808 660 ﬂorfenicol 11 µM HL60 0 3083 4809 682 sulfadimidine 13 µM PC3 0 3765 4810 665 roxarsone 15 µM HL60 0 2950 4811 654 carisoprodol 15 µM MCF7 0 3251 4812 706 nifurtimox 14 µM MCF7 0 4953 4813 647 debrisoquine 9 µM MCF7 0 3207 4814 649 sulfadimidine 13 µM HL60 0 2560 4815 664 etamsylate 15 µM HL60 0 2915 4816 682 eldeline 8 µM PC3 0 3750 4817 694 propantheline bro- 9 µM MCF7 0 4798 mide 4818 619 triprolidine 13 µM HL60 0 2376 4819 766 thiamphenicol 11 µM MCF7 0 7033 4820 749 mesalazine 26 µM HL60 0 6162 4821 658 arcaine 15 µM HL60 0 3010 4822 689 carbenoxolone 7 µM PC3 0 4093 4823 702 furaltadone 11 µM PC3 0 4313 4824 633 metanephrine 17 µM MCF7 0 1515 4825 682 indapamide 11 µM PC3 0 3778 4826 726 alfuzosin 9 µM MCF7 0 5242 4827 737 harmalol 15 µM MCF7 0 5495 4828 685 fenoprofen 7 µM MCF7 0 3612 4829 683 homosalate 15 µM PC3 0 3797 4830 727 tretinoin 1 µM PC3 0 4435 4831 637 oxolinic acid 15 µM MCF7 0 2266 4832 648 altizide 10 µM HL60 0 2527 4833 660 prasterone 12 µM HL60 0 3097 4834 664 cefalonium 9 µM HL60 0 2921 4835 720 levcycloserine 39 µM MCF7 0 4346 4836 629 meticrane 15 µM HL60 0 1834

124 4837 706 hexamethonium 10 µM MCF7 0 4965 bromide 4838 748 atropine 6 µM MCF7 0 7219 4839 747 doxycycline 8 µM MCF7 0 7195 4840 706 SR-95639A 10 µM MCF7 0 4977 4841 617 aztreonam 9 µM PC3 0 2118 4842 771 bupivacaine 12 µM MCF7 0 7435 4843 664 tracazolate 12 µM HL60 0 2919 4844 700 hydralazine 20 µM MCF7 0 4746 4845 630 prochlorperazine 7 µM HL60 0 1286 4846 632 prednisone 11 µM MCF7 0 1478 4847 676 zardaverine 15 µM MCF7 0 7347 4848 694 zardaverine 15 µM MCF7 0 4793 4849 711 PHA-00851261E 10 µM MCF7 0 3965 4850 677 imidurea 10 µM MCF7 0 3522 4851 655 niridazole 19 µM MCF7 0 3301 4852 629 dexpanthenol 19 µM HL60 0 1844 4853 720 chlorambucil 13 µM MCF7 0 4345 4854 711 citiolone 25 µM MCF7 0 3930 4855 736 sulfasalazine 10 µM MCF7 0 5446 4856 665 lymecycline 7 µM HL60 0 2953 4857 634 meclozine 9 µM HL60 0 2424 4858 659 equilin 15 µM HL60 0 3039 4859 702 sulfadimidine 13 µM PC3 0 4322 4860 678 repaglinide 9 µM MCF7 0 3558 4861 689 L-methionine 22 µM PC3 0 4070 sulfoximine 4862 749 dorzolamide 11 µM HL60 0 6142 4863 617 norﬂoxacin 13 µM PC3 0 2090 4864 1088 15(S)-15- 10 µM MCF7 0 7521 methylprostaglandin E2 4865 653 testosterone 12 µM MCF7 0 2649 4866 645 lanatoside C 4 µM HL60 0 2193 4867 712 doxorubicin 7 µM PC3 0 4610 4868 656 tolazamide 13 µM MCF7 0 2842 4869 646 terbutaline 7 µM MCF7 0 3202 4870 703 Prestwick-1080 15 µM PC3 0 4532 4871 705 N-acetylmuramic 14 µM MCF7 0 4406 acid 4872 635 ethionamide 24 µM HL60 0 2495 4873 676 zalcitabine 19 µM MCF7 0 7352

125 4874 743 isopropamide 8 µM MCF7 0 6781 iodide 4875 708 zimeldine 10 µM MCF7 0 5670 4876 691 selegiline 18 µM MCF7 0 4146 4877 704 ethionamide 24 µM PC3 0 4593 4878 677 moracizine 9 µM MCF7 0 3520 4879 692 spectinomycin 10 µM PC3 0 4187 4880 640 phenindione 18 µM HL60 0 1718 4881 690 memantine 19 µM MCF7 0 4135 4882 710 colecalciferol 10 µM PC3 0 6656 4883 642 mexiletine 19 µM MCF7 0 2324 4884 701 lomeﬂoxacin 10 µM PC3 0 4281 4885 755 urapidil 9 µM MCF7 0 6455 4886 680 halcinonide 9 µM PC3 0 3680 4887 646 antazoline 13 µM MCF7 0 3173 4888 706 retrorsine 11 µM MCF7 0 4946 4889 704 bacampicillin 8 µM PC3 0 4592 4890 718 ornidazole 18 µM PC3 0 5064 4891 718 harmalol 15 µM PC3 0 5076 4892 645 lycorine 12 µM HL60 0 2195 4893 695 cetirizine 9 µM MCF7 0 4815 4894 689 tetroquinone 21 µM PC3 0 4078 4895 695 sulfaguanidine 19 µM MCF7 0 4839 4896 695 orciprenaline 8 µM MCF7 0 4831 4897 677 loracarbef 11 µM MCF7 0 3532 4898 683 thiamazole 35 µM PC3 0 3815 4899 713 equilin 15 µM PC3 0 4659 4900 758 naloxone 11 µM MCF7 0 5606 4901 90 U0125 1 µM PC3 0 663 4902 683 guaifenesin 20 µM PC3 0 3814 4903 732 mephenytoin 18 µM PC3 0 5801 4904 651 carbinoxamine 10 µM HL60 0 2725 4905 720 homosalate 15 µM MCF7 0 4355 4906 657 phenindione 18 µM MCF7 0 2868 4907 619 glafenine 10 µM HL60 0 2387 4908 755 terguride 9 µM MCF7 0 6473 4909 703 camptothecin 11 µM PC3 0 4541 4910 714 diclofenamide 13 µM PC3 0 6686 4911 732 ondansetron 12 µM PC3 0 5796 4912 732 oxytetracycline 8 µM PC3 0 5772 4913 676 pronetalol 15 µM MCF7 0 7322

126 4914 678 trichostatin A 100 nM MCF7 0 3566 4915 735 paracetamol 26 µM MCF7 0 5384 4916 673 doxazosin 7 µM MCF7 0 3363 4917 702 piperacillin 7 µM PC3 0 4320 4918 703 PHA-00745360 10 µM PC3 0 4559 4919 650 valproic acid 50 µM HL60 0 2682 4920 702 ethoxyquin 18 µM PC3 0 4321 4921 1010 estradiol 10 nM MCF7 0 5955 4922 725 valproic acid 200 µM MCF7 0 5211 4923 1093 BCB000038 10 µM PC3 0 7547 4924 748 cefmetazole 8 µM MCF7 0 7222 4925 619 bumetanide 11 µM HL60 0 2409 4926 688 fusaric acid 22 µM PC3 0 3986 4927 703 levcycloserine 39 µM PC3 0 4524 4928 693 (+/-)-catechin 14 µM PC3 0 4255 4929 691 propylthiouracil 23 µM MCF7 0 4157 4930 728 clonidine 15 µM PC3 0 4478 4931 752 naproxen 16 µM MCF7 0 6096 4932 720 flutamide 14 µM MCF7 0 4361 4933 632 sulpiride 12 µM MCF7 0 1467 4934 646 chlortalidone 12 µM MCF7 0 3198 4935 676 metacycline 8 µM MCF7 0 7321 4936 707 ketanserin 7 µM MCF7 0 4995 4937 648 strophanthidin 10 µM HL60 0 2525 4938 737 homatropine 11 µM MCF7 0 5477 4939 654 meclocycline 6 µM MCF7 0 3277 4940 705 pancuronium bro- 5 µM MCF7 0 4393 mide 4941 699 atractyloside 5 µM MCF7 0 4717 4942 731 sulfinpyrazone 10 µM PC3 0 5753 4943 711 0317956-0000 1 µM MCF7 0 3969 4944 749 cyclopentolate 12 µM HL60 0 6132 4945 758 clenbuterol 13 µM MCF7 0 5631 4946 676 gibberellic acid 12 µM MCF7 0 7330 4947 736 flavoxate 9 µM MCF7 0 5427 4948 726 cefalexin 11 µM MCF7 0 5250 4949 692 molindone 13 µM PC3 0 4199 4950 755 (-)-MK-801 12 µM MCF7 0 6458 4951 676 Prestwick-984 9 µM MCF7 0 7323 4952 711 metamizole sodium 12 µM MCF7 0 3929 4953 685 Prestwick-674 14 µM MCF7 0 3614

127 4954 693 orciprenaline 8 µM PC3 0 4248 4955 645 Prestwick-674 14 µM HL60 0 2179 4956 731 butacaine 13 µM PC3 0 5748 4957 119 alpha-estradiol 10 nM MCF7 0 762 4958 738 dropropizine 17 µM MCF7 0 5531 4959 644 sparteine 17 µM HL60 0 2134 4960 682 0317956-0000 10 µM PC3 0 3774 4961 657 cyclizine 13 µM MCF7 0 2880 4962 642 camptothecin 11 µM MCF7 0 2321 4963 710 bezafibrate 11 µM PC3 0 6653 4964 711 spiramycin 5 µM MCF7 0 3938 4965 687 quinethazone 14 µM MCF7 0 3875 4966 660 metyrapone 18 µM HL60 0 3070 4967 1016 3-nitropropionic 10 µM MCF7 0 6367 acid 4968 690 pronetalol 15 µM MCF7 0 4104 4969 1067 alsterpaullone 10 µM PC3 0 7056 4970 1074 GW-8510 10 µM MCF7 0 7080 4971 751 heliotrine 13 µM MCF7 0 6035 4972 1048 STOCK1N-28457 20 µM PC3 0 6864 4973 741 epirizole 17 µM MCF7 0 5995 4974 673 luteolin 14 µM MCF7 0 3379 4975 727 acetylsalicylic acid 100 µM PC3 0 4428 4976 701 Prestwick-664 8 µM PC3 0 4275 4977 737 allantoin 25 µM MCF7 0 5471 4978 672 suprofen 15 µM MCF7 0 3343 4979 731 fluorocurarine 12 µM PC3 0 5741 4980 705 etidronic acid 16 µM MCF7 0 4387 4981 635 tobramycin 9 µM HL60 0 2481 4982 1007 PF-00539745-00 10 µM PC3 0 5939 4983 637 tranylcypromine 24 µM MCF7 0 2264 4984 743 anabasine 25 µM MCF7 0 6774 4985 661 denatonium ben- 9 µM HL60 0 3123 zoate 4986 756 Prestwick-981 11 µM MCF7 0 6504 4987 718 metformin 24 µM PC3 0 5068 4988 720 guaifenesin 20 µM MCF7 0 4371 4989 660 N-acetyl-L-leucine 23 µM HL60 0 3085 4990 683 spiradoline 1 µM PC3 0 3818 4991 704 pancuronium bro- 5 µM PC3 0 4570 mide 4992 702 bendroflumethiazide 9 µM PC3 0 4315

128 4993 699 0173570-0000 1 µM MCF7 0 4715 4994 627 sulfadiazine 16 µM MCF7 0 1688 4995 619 enalapril 8 µM HL60 0 2397 4996 662 alpha-yohimbine 10 µM MCF7 0 2778 4997 715 metanephrine 17 µM PC3 0 6734 4998 726 probucol 8 µM MCF7 0 5261 4999 731 tetrahydroalstonine 11 µM PC3 0 5728 5000 681 fenoprofen 7 µM PC3 0 3714 5001 663 galantamine 11 µM MCF7 0 2787 5002 704 N-acetylmuramic 14 µM PC3 0 4582 acid 5003 743 cefapirin 9 µM MCF7 0 6790 5004 651 zomepirac 13 µM HL60 0 2713 5005 757 haloperidol 10 µM MCF7 0 5604 5006 688 oxamniquine 14 µM PC3 0 4006 5007 702 mepenzolate bro- 10 µM PC3 0 4304 mide 5008 749 ronidazole 20 µM HL60 0 6134 5009 699 nalidixic acid 15 µM MCF7 0 4691 5010 677 tridihexethyl 11 µM MCF7 0 3526 5011 748 nadide 6 µM MCF7 0 7227 5012 698 isocarboxazid 17 µM PC3 0 7383 5013 650 fulvestrant 1 µM HL60 0 2665 5014 688 sisomicin 3 µM PC3 0 4014 5015 752 etanidazole 19 µM MCF7 0 6072 5016 686 eldeline 8 µM MCF7 0 3831 5017 691 tobramycin 9 µM MCF7 0 4162 5018 755 ﬂurbiprofen 16 µM MCF7 0 6472 5019 654 N-acetylmuramic 14 µM MCF7 0 3262 acid 5020 732 spironolactone 10 µM PC3 0 5781 5021 757 chlorpromazine 1 µM MCF7 0 5577 5022 758 pentetic acid 10 µM MCF7 0 5629 5023 704 naringenin 15 µM PC3 0 4597 5024 731 cefepime 7 µM PC3 0 5761 5025 704 cyanocobalamin 3 µM PC3 0 4572 5026 648 sulfamethizole 15 µM HL60 0 2536 5027 681 heliotrine 13 µM PC3 0 3717 5028 685 0179445-0000 10 µM MCF7 0 3630 5029 719 aztreonam 9 µM PC3 0 5110 5030 627 adiphenine 11 µM MCF7 0 1709 5031 758 ﬂurbiprofen 16 µM MCF7 0 5634

129 5032 635 selegiline 18 µM HL60 0 2465 5033 651 mevalolactone 31 µM HL60 0 2718 5034 708 naringin 7 µM MCF7 0 5666 5035 698 ofloxacin 11 µM PC3 0 7372 5036 756 ursodeoxycholic 10 µM MCF7 0 6484 acid 5037 747 strophanthidin 10 µM MCF7 0 7182 5038 662 noscapine 10 µM MCF7 0 2745 5039 644 quinisocaine 13 µM HL60 0 2151 5040 726 enoxacin 12 µM MCF7 0 5251 5041 699 trimethoprim 14 µM MCF7 0 4701 5042 737 piracetam 28 µM MCF7 0 5462 5043 685 fenbufen 16 µM MCF7 0 3618 5044 637 pargyline 20 µM MCF7 0 2265 5045 703 trichostatin A 100 nM PC3 0 4526 5046 705 piromidic acid 14 µM MCF7 0 4398 5047 664 sotalol 13 µM HL60 0 2918 5048 683 pramocaine 12 µM PC3 0 3811 5049 644 xylazine 18 µM HL60 0 2132 5050 711 flecainide 8 µM MCF7 0 3937 5051 738 todralazine 15 µM MCF7 0 5512 5052 741 lincomycin 9 µM MCF7 0 5992 5053 1075 GW-8510 10 µM PC3 0 7085 5054 660 (-)-atenolol 15 µM HL60 0 3067 5055 699 tiapride 11 µM MCF7 0 4686 5056 661 nabumetone 18 µM HL60 0 3108 5057 718 mafenide 18 µM PC3 0 5079 5058 705 novobiocin 6 µM MCF7 0 4392 5059 732 dexamethasone 9 µM PC3 0 5797 5060 755 rolipram 15 µM MCF7 0 6449 5061 1048 PF-00562151-00 10 µM PC3 0 6863 5062 661 nisoxetine 13 µM HL60 0 3117 5063 637 aceclofenac 11 µM MCF7 0 2281 5064 656 orciprenaline 8 µM MCF7 0 2845 5065 619 ifenprodil 8 µM HL60 0 2372 5066 663 corynanthine 10 µM MCF7 0 2786 5067 665 naftifine 12 µM HL60 0 2974 5068 646 cinnarizine 11 µM MCF7 0 3175 5069 36 pirinixic acid 100 µM MCF7 0 368 5070 691 sanguinarine 12 µM MCF7 0 4168 5071 709 Chicago Sky Blue 4 µM PC3 0 6626 6B

130 5072 656 mycophenolic acid 12 µM MCF7 0 2857 5073 703 ﬂutamide 14 µM PC3 0 4539 5074 692 sulfathiazole 16 µM PC3 0 4183 5075 749 dexpropranolol 14 µM HL60 0 6130 5076 725 acetylsalicylic acid 100 µM MCF7 0 5201 5077 633 naloxone 11 µM MCF7 0 1506 5078 664 oxamniquine 14 µM HL60 0 2924 5079 635 rifampicin 5 µM HL60 0 2487 5080 660 urapidil 9 µM HL60 0 3078 5081 700 PNU-0230031 1 µM MCF7 0 4757 5082 614 isoconazole 10 µM HL60 0 1372 5083 654 ceﬁxime 9 µM MCF7 0 3247 5084 711 eldeline 8 µM MCF7 0 3925 5085 741 proxyphylline 17 µM MCF7 0 5993 5086 651 isopropamide 8 µM HL60 0 2720 iodide 5087 709 protoveratrine A 5 µM PC3 0 6618 5088 676 Prestwick-967 26 µM MCF7 0 7346 5089 731 racecadotril 10 µM PC3 0 5755 5090 737 tridihexethyl 11 µM MCF7 0 5486 5091 660 aminohippuric acid 21 µM HL60 0 3076 5092 634 naringin 7 µM HL60 0 2425 5093 711 0317956-0000 10 µM MCF7 0 3966 5094 618 sulfamethoxazole 16 µM HL60 0 2335 5095 741 lymecycline 7 µM MCF7 0 5994 5096 737 torasemide 11 µM MCF7 0 5476 5097 747 diazoxide 17 µM MCF7 0 7168 5098 1040 5155877 10 µM PC3 0 6569 5099 693 piperine 14 µM PC3 0 4247 5100 642 nefopam 14 µM MCF7 0 2317 5101 680 riluzole 15 µM PC3 0 3666 5102 661 aminocaproic acid 30 µM HL60 0 3122 5103 751 bromopride 12 µM MCF7 0 6037 5104 756 Prestwick-972 23 µM MCF7 0 6511 5105 651 cinoxacin 15 µM HL60 0 2722 5106 676 oxamniquine 14 µM MCF7 0 7344 5107 705 alcuronium chloride 5 µM MCF7 0 4409 5108 752 delsoline 9 µM MCF7 0 6075 5109 692 probenecid 14 µM PC3 0 4185 5110 725 tanespimycin 1 µM MCF7 0 5215 5111 682 mepenzolate bro- 10 µM PC3 0 3748 mide

131 5112 634 neostigmine bro- 13 µM HL60 0 2432 mide 5113 645 mepenzolate bro- 10 µM HL60 0 2169 mide 5114 705 pentamidine 7 µM MCF7 0 4396 5115 699 salbutamol 17 µM MCF7 0 4700 5116 687 oxaprozin 14 µM MCF7 0 3876 5117 751 eldeline 8 µM MCF7 0 6026 5118 749 repaglinide 9 µM HL60 0 6135 5119 680 kawain 17 µM PC3 0 3670 5120 637 xylometazoline 14 µM MCF7 0 2270 5121 653 buspirone 9 µM MCF7 0 2637 5122 687 citalopram 1 µM MCF7 0 3903 5123 618 tiapride 11 µM HL60 0 2331 5124 672 tetroquinone 21 µM MCF7 0 3338 5125 692 naftopidil 9 µM PC3 0 4193 5126 672 amiprilose 12 µM MCF7 0 3339 5127 691 tolmetin 13 µM MCF7 0 4167 5128 682 ﬂunisolide 9 µM PC3 0 3747 5129 658 cefsulodin 7 µM HL60 0 2988 5130 686 ethisterone 13 µM MCF7 0 3864 5131 659 ethaverine 9 µM HL60 0 3037 5132 737 metformin 24 µM MCF7 0 5487 5133 731 cytisine 21 µM PC3 0 5739 5134 725 tretinoin 1 µM MCF7 0 5208 5135 688 phenacetin 22 µM PC3 0 3992 5136 738 sulfaphenazole 13 µM MCF7 0 5507 5137 737 Prestwick-920 14 µM MCF7 0 5475 5138 750 valproic acid 1 mM HL60 0 6168 5139 682 0317956-0000 1 µM PC3 0 3777 5140 719 phensuximide 21 µM PC3 0 5097 5141 656 rifampicin 5 µM MCF7 0 2847 5142 636 diazoxide 17 µM MCF7 0 2214 5143 664 tocainide 17 µM HL60 0 2931 5144 677 risperidone 10 µM MCF7 0 3508 5145 657 chloroquine 8 µM MCF7 0 2869 5146 699 pentolonium 7 µM MCF7 0 4699 5147 648 estropipate 9 µM HL60 0 2506 5148 651 hecogenin 9 µM HL60 0 2716 5149 728 dacarbazine 22 µM PC3 0 4480 5150 644 bicuculline 11 µM HL60 0 2139 5151 699 Prestwick-665 12 µM MCF7 0 4704

132 5152 690 gramine 23 µM MCF7 0 4118 5153 720 nialamide 13 µM MCF7 0 4347 5154 614 chlorphenamine 10 µM HL60 0 1371 5155 743 tetryzoline 17 µM MCF7 0 6769 5156 761 clorsulon 11 µM PC3 0 7264 5157 690 6-azathymine 31 µM MCF7 0 4106 5158 661 Prestwick-981 11 µM HL60 0 3125 5159 687 tolbutamide 15 µM MCF7 0 3886 5160 699 griseofulvin 11 µM MCF7 0 4687 5161 1052 AH-23848 1 µM PC3 0 6885 5162 755 metyrapone 18 µM MCF7 0 6447 5163 637 thalidomide 15 µM MCF7 0 2258 5164 737 octopamine 21 µM MCF7 0 5469 5165 736 fenoterol 10 µM MCF7 0 5432 5166 692 lumicolchicine 10 µM PC3 0 4195 5167 683 quinethazone 14 µM PC3 0 3793 5168 634 biotin 16 µM HL60 0 2428 5169 642 ketoprofen 16 µM MCF7 0 2316 5170 711 proglumide 12 µM MCF7 0 3972 5171 725 valproic acid 50 µM MCF7 0 5219 5172 732 lobeline 11 µM PC3 0 5784 5173 676 etilefrine 18 µM MCF7 0 7350 5174 744 cefalotin 10 µM MCF7 0 6819 5175 665 risperidone 10 µM HL60 0 2947 5176 646 streptomycin 3 µM MCF7 0 3195 5177 646 bambuterol 10 µM MCF7 0 3199 5178 664 pancuronium bro- 5 µM HL60 0 2909 mide 5179 731 tranexamic acid 25 µM PC3 0 5762 5180 658 suprofen 15 µM HL60 0 3005 5181 719 adipiodone 4 µM PC3 0 5085 5182 694 meptazinol 15 µM MCF7 0 4774 5183 741 pivmecillinam 8 µM MCF7 0 6014 5184 681 6- 18 µM PC3 0 3726 benzylaminopurine 5185 752 nadide 6 µM MCF7 0 6091 5186 676 letrozole 14 µM MCF7 0 7336 5187 758 probucol 8 µM MCF7 0 5626 5188 1023 AG-013608 10 µM PC3 0 6400 5189 741 iobenguane 11 µM MCF7 0 6002 5190 685 bromopride 12 µM MCF7 0 3617 5191 709 dl-alpha tocopherol 9 µM PC3 0 6616

133 5192 685 prilocaine 16 µM MCF7 0 3624 5193 693 seneciphylline 12 µM PC3 0 4238 5194 732 demecarium bro- 6 µM PC3 0 5795 mide 5195 728 pipenzolate bro- 9 µM PC3 0 4484 mide 5196 691 cefsulodin 7 µM MCF7 0 4148 5197 644 galantamine 11 µM HL60 0 2131 5198 699 isocarboxazid 17 µM MCF7 0 4706 5199 683 nialamide 13 µM PC3 0 3790 5200 619 aminoglutethimide 17 µM HL60 0 2390 5201 732 cinoxacin 15 µM PC3 0 5783 5202 650 LY-294002 100 nM HL60 0 2676 5203 673 nicotinic acid 32 µM MCF7 0 3381 5204 751 2,6- 27 µM MCF7 0 6049 dimethylpiperidine 5205 646 methylprednisolone 11 µM MCF7 0 3183 5206 698 Prestwick-675 10 µM PC3 0 7381 5207 703 CP-690334-01 1 µM PC3 0 4561 5208 663 salsolinol 15 µM MCF7 0 2791 5209 646 alprenolol 14 µM MCF7 0 3188 5210 714 hydrocortisone 11 µM PC3 0 6684 5211 737 chloramphenicol 12 µM MCF7 0 5466 5212 756 denatonium ben- 9 µM MCF7 0 6502 zoate 5213 671 cefapirin 9 µM MCF7 0 3471 5214 700 sulfamerazine 15 µM MCF7 0 4740 5215 637 methocarbamol 17 µM MCF7 0 2274 5216 704 tiabendazole 20 µM PC3 0 4579 5217 676 alcuronium chloride 5 µM MCF7 0 7345 5218 744 altizide 10 µM MCF7 0 6829 5219 708 oleandomycin 5 µM MCF7 0 5676 5220 758 cefalexin 11 µM MCF7 0 5615 5221 708 kanamycin 7 µM MCF7 0 5686 5222 702 0317956-0000 10 µM PC3 0 4331 5223 632 isoxsuprine 12 µM MCF7 0 1485 5224 701 prilocaine 16 µM PC3 0 4284 5225 629 moxisylyte 13 µM HL60 0 1846 5226 720 quinethazone 14 µM MCF7 0 4351 5227 1066 alsterpaullone 10 µM MCF7 0 7051 5228 699 metaraminol 9 µM MCF7 0 4692 5229 728 kinetin 19 µM PC3 0 4477 5230 732 dorzolamide 11 µM PC3 0 5785

134 5231 714 ﬂorfenicol 11 µM PC3 0 6701 5232 705 harman 18 µM MCF7 0 4408 5233 641 ellipticine 16 µM HL60 0 1765 5234 672 scopolamine 12 µM MCF7 0 3357 5235 688 etifenin 12 µM PC3 0 3998 5236 648 suxibuzone 9 µM HL60 0 2503 5237 711 eucatropine 12 µM MCF7 0 3935 5238 686 eucatropine 12 µM MCF7 0 3841 5239 655 naringin 7 µM MCF7 0 3286 5240 726 naloxone 11 µM MCF7 0 5243 5241 637 aztreonam 9 µM MCF7 0 2282 5242 711 piperacillin 7 µM MCF7 0 3939 5243 6 chlorpropamide 100 µM MCF7 0 144 5244 636 picotamide 10 µM MCF7 0 2233 5245 680 trimethoprim 14 µM PC3 0 3678 5246 633 oleandomycin 5 µM MCF7 0 1518 5247 654 lactobionic acid 11 µM MCF7 0 3246 5248 661 chrysin 16 µM HL60 0 3106 5249 672 trichlormethiazide 11 µM MCF7 0 3337 5250 693 amprolium 13 µM PC3 0 4241 5251 731 dienestrol 15 µM PC3 0 5727 5252 708 hymecromone 23 µM MCF7 0 5684 5253 678 piretanide 11 µM MCF7 0 3567 5254 647 probucol 8 µM MCF7 0 3223 5255 744 isocorydine 12 µM MCF7 0 6843 5256 695 7- 15 µM MCF7 0 4826 aminocephalosporanic acid 5257 737 roxarsone 15 µM MCF7 0 5470 5258 688 ethambutol 14 µM PC3 0 4001 5259 1073 alsterpaullone 10 µM PC3 0 7078 5260 705 bicuculline 11 µM MCF7 0 4397 5261 636 neomycin 4 µM MCF7 0 2229 5262 644 diﬂorasone 8 µM HL60 0 2142 5263 646 albendazole 15 µM MCF7 0 3164 5264 619 bufexamac 18 µM HL60 0 2382 5265 646 clonidine 15 µM MCF7 0 3172 5266 676 apramycin 7 µM MCF7 0 7334 5267 648 abamectin 5 µM HL60 0 2519 5268 653 mimosine 20 µM MCF7 0 2638 5269 751 foliosidine 13 µM MCF7 0 6057 5270 647 alfuzosin 9 µM MCF7 0 3203

135 5271 673 (+)-isoprenaline 11 µM MCF7 0 3384 5272 632 captopril 17 µM MCF7 0 1488 5273 755 N-acetyl-L-leucine 23 µM MCF7 0 6462 5274 673 rolitetracycline 8 µM MCF7 0 3369 5275 702 pempidine 13 µM PC3 0 4307 5276 647 amikacin 7 µM MCF7 0 3233 5277 736 iproniazid 14 µM MCF7 0 5458 5278 647 practolol 15 µM MCF7 0 3204 5279 699 kawain 17 µM MCF7 0 4693 5280 715 buspirone 9 µM PC3 0 6743 5281 637 piroxicam 12 µM MCF7 0 2252 5282 682 dicoumarol 12 µM PC3 0 3766 5283 644 cinchonine 14 µM HL60 0 2133 5284 749 chloropyrazine 35 µM HL60 0 6148 5285 644 gramine 23 µM HL60 0 2143 5286 653 droperidol 11 µM MCF7 0 2645 5287 658 amiprilose 12 µM HL60 0 3000 5288 755 dexibuprofen 19 µM MCF7 0 6471 5289 705 tiabendazole 20 µM MCF7 0 4402 5290 752 cefmetazole 8 µM MCF7 0 6086 5291 749 oxprenolol 13 µM HL60 0 6145 5292 654 cyanocobalamin 3 µM MCF7 0 3252 5293 703 oxaprozin 14 µM PC3 0 4530 5294 677 pivampicillin 9 µM MCF7 0 3506 5295 636 nomifensine 11 µM MCF7 0 2224 5296 691 sotalol 13 µM MCF7 0 4160 5297 710 glipizide 9 µM PC3 0 6645 5298 681 flunixin 8 µM PC3 0 3713 5299 714 ciprofloxacin 11 µM PC3 0 6700 5300 635 benperidol 10 µM HL60 0 2475 5301 1090 BCB000039 10 µM MCF7 0 7531 5302 700 flumetasone 10 µM MCF7 0 4734 5303 736 betazole 27 µM MCF7 0 5445 5304 758 sulfafurazole 15 µM MCF7 0 5622 5305 619 disopyramide 12 µM HL60 0 2408 5306 658 indoprofen 14 µM HL60 0 3007 5307 749 ramipril 10 µM HL60 0 6150 5308 706 Prestwick-984 9 µM MCF7 0 4948 5309 646 amodiaquine 9 µM MCF7 0 3186 5310 646 fluphenazine 8 µM MCF7 0 3194 5311 735 aminohippuric acid 21 µM MCF7 0 5394

136 5312 715 ergocalciferol 10 µM PC3 0 6746 5313 741 nifenazone 13 µM MCF7 0 6016 5314 702 deferoxamine 6 µM PC3 0 4317 5315 664 moxonidine 17 µM HL60 0 2923 5316 637 levamisole 17 µM MCF7 0 2257 5317 619 dyclonine 12 µM HL60 0 2392 5318 654 SR-95531 11 µM MCF7 0 3253 5319 744 ampyrone 20 µM MCF7 0 6845 5320 1076 AR-A014418 10 µM MCF7 0 7092 5321 655 neostigmine bro- 13 µM MCF7 0 3294 mide 5322 743 ribostamycin 7 µM MCF7 0 6765 5323 695 doxylamine 10 µM MCF7 0 4819 5324 648 cefuroxime 9 µM HL60 0 2526 5325 644 gelsemine 12 µM HL60 0 2162 5326 634 velnacrine 12 µM HL60 0 2430 5327 744 clidinium bromide 9 µM MCF7 0 6837 5328 646 glibenclamide 8 µM MCF7 0 3163 5329 657 Trolox C 16 µM MCF7 0 2883 5330 646 fipexide 9 µM MCF7 0 3176 5331 673 ioversol 5 µM MCF7 0 3365 5332 644 canavanine 14 µM HL60 0 2141 5333 636 mianserin 13 µM MCF7 0 2231 5334 694 molindone 13 µM MCF7 0 4784 5335 1048 fulvestrant 1 µM PC3 0 6867 5336 637 ornidazole 18 µM MCF7 0 2272 5337 713 3-acetylcoumarin 21 µM PC3 0 4664 5338 756 trapidil 19 µM MCF7 0 6515 5339 678 methanthelinium 10 µM MCF7 0 3560 bromide 5340 741 nipecotic acid 31 µM MCF7 0 5999 5341 690 N-acetyl-L-aspartic 23 µM MCF7 0 4125 acid 5342 637 alverine 8 µM MCF7 0 2273 5343 637 fenspiride 13 µM MCF7 0 2269 5344 637 norfloxacin 13 µM MCF7 0 2253 5345 700 meclofenoxate 14 µM MCF7 0 4729 5346 633 diltiazem 9 µM MCF7 0 1532 5347 727 alpha-estradiol 10 nM PC3 0 4434 5348 751 myosmine 27 µM MCF7 0 6055 5349 664 metacycline 8 µM HL60 0 2901 5350 711 bendroflumethiazide 9 µM MCF7 0 3934

137 5351 1005 pioglitazone 10 µM PC3 0 5930 5352 741 gliquidone 8 µM MCF7 0 6004 5353 651 amrinone 21 µM HL60 0 2724 5354 676 cefalonium 9 µM MCF7 0 7341 5355 655 velnacrine 12 µM MCF7 0 3292 5356 646 labetalol 11 µM MCF7 0 3167 5357 672 oxolamine 9 µM MCF7 0 3344 5358 693 corynanthine 10 µM PC3 0 4227 5359 699 cefamandole 8 µM MCF7 0 4718 5360 637 hydrastinine 16 µM MCF7 0 2283 5361 690 mycophenolic acid 12 µM MCF7 0 4137 5362 672 benzthiazide 9 µM MCF7 0 3329 5363 1054 pioglitazone 10 µM PC3 0 6893 5364 660 flucytosine 31 µM HL60 0 3073 5365 732 ellipticine 16 µM PC3 0 5779 5366 731 mevalolactone 31 µM PC3 0 5738 5367 637 ranitidine 11 µM MCF7 0 2251 5368 751 citiolone 25 µM MCF7 0 6031 5369 636 dihydrostreptomycin 3 µM MCF7 0 2237 5370 693 phenazone 21 µM PC3 0 4251 5371 693 theophylline 20 µM PC3 0 4228 5372 755 pralidoxime 23 µM MCF7 0 6443 5373 752 suxibuzone 9 µM MCF7 0 6065 5374 636 aminophenazone 17 µM MCF7 0 2222 5375 637 flumequine 15 µM MCF7 0 2276 5376 715 ioversol 5 µM PC3 0 6726 5377 758 phthalylsulfathiazole 10 µM MCF7 0 5614 5378 703 tolbutamide 15 µM PC3 0 4540 5379 672 liothyronine 6 µM MCF7 0 3324 5380 690 etofenamate 11 µM MCF7 0 4108 5381 757 monorden 100 nM MCF7 0 5579 5382 646 mebeverine 9 µM MCF7 0 3193 5383 701 hydralazine 20 µM PC3 0 4282 5384 757 alpha-estradiol 10 nM MCF7 0 5570 5385 731 ciprofibrate 14 µM PC3 0 5740 5386 693 doxylamine 10 µM PC3 0 4235 5387 40 genistein 10 µM MCF7 0 382 5388 693 SR-95531 11 µM PC3 0 4236 5389 664 nifurtimox 14 µM HL60 0 2908 5390 705 tetramisole 17 µM MCF7 0 4412 5391 680 Prestwick-675 10 µM PC3 0 3682

138 5392 757 tanespimycin 1 µM MCF7 0 5566 5393 685 demeclocycline 8 µM MCF7 0 3604 5394 673 aminophylline 10 µM MCF7 0 3374 5395 736 procaine 15 µM MCF7 0 5430 5396 700 Prestwick-664 8 µM MCF7 0 4737 5397 703 chlorambucil 13 µM PC3 0 4523 5398 744 piretanide 11 µM MCF7 0 6828 5399 634 progesterone 13 µM HL60 0 2426 5400 707 (+)-isoprenaline 11 µM MCF7 0 5009 5401 752 estropipate 9 µM MCF7 0 6068 5402 646 sulﬁnpyrazone 10 µM MCF7 0 3192 5403 758 3-acetylcoumarin 21 µM MCF7 0 5624 5404 726 guanfacine 14 µM MCF7 0 5256 5405 690 oxamniquine 14 µM MCF7 0 4124 5406 651 butacaine 13 µM HL60 0 2728 5407 755 altretamine 19 µM MCF7 0 6467 5408 673 crotamiton 20 µM MCF7 0 3388 5409 1000 estradiol 10 nM MCF7 0 5905 5410 681 demeclocycline 8 µM PC3 0 3706 5411 736 piribedil 12 µM MCF7 0 5434 5412 677 mecamylamine 20 µM MCF7 0 3525 5413 646 tremorine 15 µM MCF7 0 3196 5414 657 iobenguane 11 µM MCF7 0 2878 5415 637 scopolamine N- 10 µM MCF7 0 2262 oxide 5416 646 praziquantel 13 µM MCF7 0 3189 5417 705 cyanocobalamin 3 µM MCF7 0 4395 5418 731 ricinine 24 µM PC3 0 5725 5419 755 terguride 12 µM MCF7 0 6459 5420 688 carbarsone 15 µM PC3 0 3991 5421 646 quinidine 11 µM MCF7 0 3191 5422 662 dipivefrine 10 µM MCF7 0 2744 5423 690 Prestwick-864 35 µM MCF7 0 4113 5424 731 cromoglicic acid 8 µM PC3 0 5754 5425 686 metamizole sodium 12 µM MCF7 0 3835 5426 702 PHA-00851261E 10 µM PC3 0 4330 5427 705 apigenin 15 µM MCF7 0 4401 5428 691 cimetidine 16 µM MCF7 0 4144 5429 673 Prestwick-860 35 µM MCF7 0 3378 5430 657 tubocurarine chlo- 5 µM MCF7 0 2887 ride 5431 703 phenelzine 17 µM PC3 0 4538

139 5432 743 naproxen 16 µM MCF7 0 6794 5433 661 scopoletin 21 µM HL60 0 3131 5434 720 ciclacillin 12 µM MCF7 0 4358 5435 695 fosfosal 18 µM MCF7 0 4823 5436 720 trichostatin A 100 nM MCF7 0 4348 5437 719 hyoscyamine 14 µM PC3 0 5099 5438 715 hemicholinium 7 µM PC3 0 6739 5439 691 metacycline 8 µM MCF7 0 4143 5440 637 etodolac 14 µM MCF7 0 2254 5441 715 zaprinast 15 µM PC3 0 6749 5442 657 dirithromycin 5 µM MCF7 0 2863 5443 672 theophylline 20 µM MCF7 0 3326 5444 744 pipenzolate bro- 9 µM MCF7 0 6821 mide 5445 658 procyclidine 12 µM HL60 0 2991 5446 636 gallamine triethio- 4 µM MCF7 0 2221 dide 5447 655 hydrocortisone 11 µM MCF7 0 3284 5448 725 estradiol 100 nM MCF7 0 5205 5449 699 sulfamethoxazole 16 µM MCF7 0 4690 5450 637 oxymetazoline 13 µM MCF7 0 2278 5451 690 fusaric acid 22 µM MCF7 0 4105 5452 741 tiletamine 15 µM MCF7 0 6013 5453 711 sulfadimidine 13 µM MCF7 0 3940 5454 687 homosalate 15 µM MCF7 0 3879 5455 700 tropicamide 14 µM MCF7 0 4744 5456 755 aminohippuric acid 21 µM MCF7 0 6453 5457 731 guanethidine 13 µM PC3 0 5731 5458 741 fenspiride 13 µM MCF7 0 6001 5459 691 cefadroxil 11 µM MCF7 0 4161 5460 758 enoxacin 12 µM MCF7 0 5616 5461 637 ﬂufenamic acid 14 µM MCF7 0 2267 5462 749 meropenem 10 µM HL60 0 6141 5463 711 benfotiamine 9 µM MCF7 0 3931 5464 731 cyclopentolate 12 µM PC3 0 5734 5465 619 bupivacaine 12 µM HL60 0 2404 5466 672 piromidic acid 14 µM MCF7 0 3335 5467 751 Prestwick-664 8 µM MCF7 0 6033 5468 693 salsolidin 16 µM PC3 0 4226 5469 732 naltrexone 10 µM PC3 0 5765 5470 741 ozagrel 15 µM MCF7 0 5983 5471 672 fosfosal 18 µM MCF7 0 3336

140 5472 655 ergocalciferol 10 µM MCF7 0 3304 5473 755 flucytosine 31 µM MCF7 0 6450 5474 649 spiramycin 5 µM HL60 0 2558 5475 637 gemfibrozil 16 µM MCF7 0 2277 5476 699 mephentermine 9 µM MCF7 0 4707 5477 634 amiodarone 6 µM HL60 0 2434 5478 1006 H-7 100 µM MCF7 0 5936 5479 693 7- 15 µM PC3 0 4242 aminocephalosporanic acid 5480 749 Prestwick-1084 16 µM HL60 0 6125 5481 727 rosiglitazone 10 µM PC3 0 4457 5482 1012 H-7 100 µM MCF7 0 5963 5483 731 chloropyrazine 35 µM PC3 0 5750 5484 647 mitoxantrone 8 µM MCF7 0 3232 5485 672 etidronic acid 16 µM MCF7 0 3325 5486 1050 0175029-0000 10 µM PC3 0 6875 5487 692 epitiostanol 13 µM PC3 0 4204 5488 658 piromidic acid 14 µM HL60 0 2996 5489 755 lorglumide 8 µM MCF7 0 6456 5490 705 prednisone 11 µM MCF7 0 4400 5491 731 meprylcaine 15 µM PC3 0 5723 5492 700 heliotrine 13 µM MCF7 0 4739 5493 672 nafcillin 9 µM MCF7 0 3323 5494 645 methylbenzethonium 9 µM HL60 0 2190 chloride 5495 647 kanamycin 7 µM MCF7 0 3224 5496 648 anabasine 25 µM HL60 0 2512 5497 744 atropine oxide 12 µM MCF7 0 6812 5498 636 atropine oxide 12 µM MCF7 0 2216 5499 691 levothyroxine 5 µM MCF7 0 4150 sodium 5500 672 Prestwick-857 12 µM MCF7 0 3355 5501 1048 SC-560 10 µM PC3 0 6865 5502 651 cefapirin 9 µM HL60 0 2730 5503 655 carbimazole 21 µM MCF7 0 3299 5504 673 diclofenamide 13 µM MCF7 0 3366 5505 649 furaltadone 11 µM HL60 0 2554 5506 655 doxorubicin 7 µM MCF7 0 3291 5507 728 epivincamine 11 µM PC3 0 4500 5508 741 norfloxacin 13 µM MCF7 0 5985 5509 672 azacitidine 16 µM MCF7 0 3348

141 5510 744 kinetin 19 µM MCF7 0 6813 5511 690 cinchonine 14 µM MCF7 0 4107 5512 692 galantamine 11 µM PC3 0 4186 5513 741 phenindione 18 µM MCF7 0 5991 5514 619 difenidol 12 µM HL60 0 2374 5515 648 sulfaquinoxaline 12 µM HL60 0 2528 5516 1007 H-7 100 µM PC3 0 5941 5517 24 staurosporine 1 µM MCF7 0 312 5518 672 procyclidine 12 µM MCF7 0 3330 5519 672 Prestwick-864 35 µM MCF7 0 3333 5520 687 levcycloserine 39 µM MCF7 0 3870 5521 645 sulfamerazine 15 µM HL60 0 2181 5522 646 bupropion 14 µM MCF7 0 3180 5523 692 trichlormethiazide 11 µM PC3 0 4198 5524 673 paracetamol 26 µM MCF7 0 3364 5525 653 zoxazolamine 24 µM MCF7 0 2625 5526 704 harman 18 µM PC3 0 4584 5527 680 0175029-0000 10 µM PC3 0 3691 5528 737 pivampicillin 9 µM MCF7 0 5465 5529 672 roxithromycin 5 µM MCF7 0 3331 5530 676 molindone 13 µM MCF7 0 7337 5531 654 carcinine 22 µM MCF7 0 3242 5532 653 ketoconazole 8 µM MCF7 0 2640 5533 744 sulfanilamide 23 µM MCF7 0 6810 5534 720 phenelzine 17 µM MCF7 0 4360 5535 752 ricinine 24 µM MCF7 0 6067 5536 702 acacetin 14 µM PC3 0 4324 5537 703 quinethazone 14 µM PC3 0 4529 5538 690 nafcillin 9 µM MCF7 0 4103 5539 683 2,6- 27 µM PC3 0 3806 dimethylpiperidine 5540 731 gallamine triethio- 4 µM PC3 0 5735 dide 5541 715 mitoxantrone 8 µM PC3 0 6755 5542 756 ketorolac 11 µM MCF7 0 6489 5543 690 etifenin 12 µM MCF7 0 4117 5544 744 stachydrine 22 µM MCF7 0 6805 5545 720 Prestwick-1080 15 µM MCF7 0 4354 5546 689 metacycline 8 µM PC3 0 4062 5547 706 daunorubicin 7 µM MCF7 0 4983 5548 749 cycloserine 39 µM HL60 0 6139 5549 636 naltrexone 10 µM MCF7 0 2209

142 5550 732 Prestwick-1085 15 µM PC3 0 5774 5551 690 carbarsone 15 µM MCF7 0 4110 5552 677 iopanoic acid 7 µM MCF7 0 3527 5553 645 Prestwick-675 10 µM HL60 0 2187 5554 699 0175029-0000 10 µM MCF7 0 4713 5555 646 vinpocetine 11 µM MCF7 0 3174 5556 672 spectinomycin 10 µM MCF7 0 3327 5557 1013 H-7 100 µM PC3 0 5968 5558 690 phenacetin 22 µM MCF7 0 4111 5559 708 doxorubicin 7 µM MCF7 0 5671 5560 61 monorden 100 nM PC3 -0.417 449 5561 54 chlorpromazine 1 µM MCF7 -0.424 426 5562 55 rosiglitazone 10 µM PC3 -0.428 430 5563 23 exisulind 50 µM MCF7 -0.431 309 5564 611 ciproﬂoxacin 11 µM PC3 -0.434 1939 5565 21 prednisolone 1 µM MCF7 -0.441 265 5566 24 NU-1025 100 µM MCF7 -0.442 313 5567 120 estradiol 10 nM HL60 -0.448 782 5568 611 azathioprine 14 µM PC3 -0.452 1945 5569 26b monorden 100 nM MCF7 -0.463 325 5570 43 sodium phenylbu- 1 mM MCF7 -0.476 408 tyrate 5571 659 nizatidine 12 µM HL60 -0.492 3047 5572 610 4- 20 µM PC3 -0.513 1915 hydroxyphenazone 5573 70 tetraethylenepentamine100 µM ssMCF7 -0.516 498 5574 45 estradiol 10 nM ssMCF7 -0.516 414 5575 61 TTNPB 100 nM PC3 -0.517 451 5576 116 estradiol 10 nM PC3 -0.519 665 5577 17 TTNPB 100 nM MCF7 -0.52 223 5578 19 rofecoxib 10 µM MCF7 -0.537 256 5579 63 tetraethylenepentamine100 µM PC3 -0.541 457 5580 764 cefoxitin 9 µM PC3 -0.541 7148 5581 1059 PF-00562151-00 10 µM MCF7 -0.541 6912 5582 641 atropine 6 µM HL60 -0.541 1768 5583 681 hydralazine 20 µM PC3 -0.547 3724 5584 22a tacrolimus 1 µM MCF7 -0.547 284 5585 688 amiprilose 12 µM PC3 -0.547 4000 5586 21 genistein 1 µM MCF7 -0.551 268 5587 688 cefotetan 7 µM PC3 -0.553 3997 5588 22a quercetin 1 µM MCF7 -0.558 283 5589 95 monastrol 100 µM MCF7 -0.559 596

143 5590 658 Prestwick-864 35 µM HL60 -0.559 2994 5591 693 tocainide 17 µM PC3 -0.562 4256 5592 1077 SC-19220 10 µM PC3 -0.567 7095 5593 628 atracurium besilate 3 µM PC3 -0.567 1824 5594 33 valproic acid 50 µM MCF7 -0.569 348 5595 21 thalidomide 100 µM MCF7 -0.569 266 5596 612 doxylamine 10 µM HL60 -0.57 1973 5597 623 betamethasone 10 µM HL60 -0.571 1590 5598 691 decamethonium 10 µM MCF7 -0.572 4174 bromide 5599 45 nordihydroguaiaretic 1 µM ssMCF7 -0.572 415 acid 5600 640 artemisinin 14 µM HL60 -0.575 1714 5601 31 fasudil 10 µM MCF7 -0.576 343 5602 1046 PHA-00767505E 10 µM PC3 -0.577 6591 5603 1013 fulvestrant 1 µM PC3 -0.577 5969 5604 612 pheniramine 11 µM HL60 -0.579 1992 5605 617 aceclofenac 11 µM PC3 -0.58 2117 5606 661 alfadolone 10 µM HL60 -0.582 3127 5607 681 prilocaine 16 µM PC3 -0.582 3727 5608 660 nilutamide 13 µM HL60 -0.583 3104 5609 614 isoniazid 29 µM HL60 -0.584 1399 5610 1073 PHA-00816795 10 µM PC3 -0.585 7076 5611 727 valproic acid 200 µM PC3 -0.586 4438 5612 728 furosemide 12 µM PC3 -0.589 4503 5613 612 diphemanil metil- 10 µM HL60 -0.59 1994 sulfate 5614 688 cinchonine 14 µM PC3 -0.59 3988 5615 688 metronidazole 23 µM PC3 -0.592 4023 5616 701 myosmine 27 µM PC3 -0.593 4293 5617 641 harmine 16 µM HL60 -0.594 1758 5618 704 diphemanil metil- 10 µM PC3 -0.595 4591 sulfate 5619 659 pentetic acid 10 µM HL60 -0.596 3049 5620 689 Prestwick-691 14 µM PC3 -0.598 4092 5621 628 todralazine 15 µM PC3 -0.6 1799 5622 688 tolazamide 13 µM PC3 -0.6 4003 5623 514 phentolamine 12 µM MCF7 -0.601 1138 5624 691 gelsemine 12 µM MCF7 -0.601 4177 5625 40 cobalt chloride 100 µM MCF7 -0.603 383 5626 713 serotonin 19 µM PC3 -0.604 4673 5627 680 atractyloside 5 µM PC3 -0.604 3695 5628 681 myosmine 27 µM PC3 -0.605 3737

144 5629 690 rifampicin 5 µM MCF7 -0.607 4126 5630 95 arachidonyltrifluoromethane10 µM MCF7 -0.607 594 5631 22a fludrocortisone 1 µM MCF7 -0.608 281 5632 705 captopril 17 µM MCF7 -0.608 4410 5633 711 indapamide 11 µM MCF7 -0.609 3970 5634 693 letrozole 14 µM PC3 -0.611 4240 5635 733 cinnarizine 11 µM PC3 -0.611 5817 5636 1084 CP-863187 10 µM MCF7 -0.612 7508 5637 641 monocrotaline 12 µM HL60 -0.613 1757 5638 688 rifampicin 5 µM PC3 -0.614 4008 5639 612 sulfaguanidine 19 µM HL60 -0.614 1995 5640 1014 pioglitazone 10 µM MCF7 -0.614 5972 5641 681 metoclopramide 12 µM PC3 -0.614 3728 5642 693 succinylsulfathiazole 11 µM PC3 -0.615 4265 5643 733 ticarcillin 9 µM PC3 -0.615 5829 5644 658 tolmetin 13 µM HL60 -0.616 3009 5645 1094 CP-863187 10 µM MCF7 -0.617 7553 5646 1005 PF-00875133-00 10 µM PC3 -0.617 5928 5647 1062 H-89 500 nM PC3 -0.619 6921 5648 1061 carmustine 100 µM MCF7 -0.62 6914 5649 616 dihydrostreptomycin 3 µM PC3 -0.62 2074 5650 623 hycanthone 11 µM HL60 -0.621 1614 5651 689 trimethobenzamide 9 µM PC3 -0.621 4100 5652 757 estradiol 100 nM MCF7 -0.621 5568 5653 689 tenoxicam 12 µM PC3 -0.624 4102 5654 663 cinchonine 14 µM MCF7 -0.625 2789 5655 614 atropine oxide 12 µM HL60 -0.626 1370 5656 661 Prestwick-972 23 µM HL60 -0.626 3132 5657 640 tetracaine 13 µM HL60 -0.626 1739 5658 59 arachidonic acid 10 µM MCF7 -0.627 441 5659 761 hydroflumethiazide 12 µM PC3 -0.628 7259 5660 704 paromomycin 6 µM PC3 -0.629 4595 5661 681 0179445-0000 1 µM PC3 -0.629 3736 5662 514 minocycline 11 µM MCF7 -0.63 1135 5663 729 meglumine 20 µM MCF7 -0.631 5285 5664 745 tetracycline 8 µM MCF7 -0.633 6233 5665 688 chlorogenic acid 11 µM PC3 -0.633 4024 5666 90 splitomicin 20 µM PC3 -0.633 661 5667 641 yohimbine 10 µM HL60 -0.634 1763 5668 53 LY-294002 100 nM MCF7 -0.634 424

145 5669 753 2- 23 µM PC3 -0.635 6321 aminobenzenesulfonamide 5670 661 pizotifen 9 µM HL60 -0.635 3134 5671 658 trimipramine 10 µM HL60 -0.635 3004 5672 649 guanadrel 8 µM HL60 -0.637 2575 5673 612 tolnaftate 13 µM HL60 -0.638 2001 5674 692 pepstatin 6 µM PC3 -0.64 4206 5675 659 thioperamide 10 µM HL60 -0.641 3055 5676 631 7- 15 µM HL60 -0.641 1322 aminocephalosporanic acid 5677 1089 pioglitazone 10 µM PC3 -0.641 7528 5678 94 bucladesine 20 µM MCF7 -0.641 591 5679 749 propoxycaine 12 µM HL60 -0.643 6161 5680 698 mephentermine 9 µM PC3 -0.644 7384 5681 683 PHA-00745360 10 µM PC3 -0.645 3824 5682 764 sulfapyridine 16 µM PC3 -0.645 7151 5683 1041 alprostadil 10 µM MCF7 -0.645 6576 5684 67 iloprost 1 µM MCF7 -0.645 488 5685 656 methoxamine 16 µM MCF7 -0.646 2848 5686 659 felbinac 19 µM HL60 -0.647 3061 5687 694 pregnenolone 13 µM MCF7 -0.647 4802 5688 1029 C-75 10 µM PC3 -0.647 6428 5689 659 2- 23 µM HL60 -0.648 3063 aminobenzenesulfonamide 5690 736 scopolamine N- 10 µM MCF7 -0.648 5436 oxide 5691 658 oxolamine 9 µM HL60 -0.649 3006 5692 661 gliquidone 8 µM HL60 -0.649 3126 5693 737 ornidazole 18 µM MCF7 -0.65 5483 5694 735 nizatidine 12 µM MCF7 -0.651 5406 5695 658 tetroquinone 21 µM HL60 -0.652 2999 5696 704 terconazole 8 µM PC3 -0.652 4583 5697 733 iopamidol 5 µM PC3 -0.653 5832 5698 687 Prestwick-1080 15 µM MCF7 -0.654 3878 5699 703 PHA-00745360 1 µM PC3 -0.654 4562 5700 17 tomelukast 1 µM MCF7 -0.654 222 5701 726 pentetic acid 10 µM MCF7 -0.655 5264 5702 733 ursolic acid 9 µM PC3 -0.656 5825 5703 646 furosemide 12 µM MCF7 -0.657 3197 5704 651 bergenin 12 µM HL60 -0.658 2726 5705 505 5186223 12 µM MCF7 -0.659 885 5706 1019 valdecoxib 10 µM PC3 -0.659 6378

146 5707 712 iohexol 5 µM PC3 -0.66 4643 5708 640 Trolox C 16 µM HL60 -0.661 1734 5709 690 boldine 12 µM MCF7 -0.662 4122 5710 646 ketotifen 9 µM MCF7 -0.662 3200 5711 738 pentetrazol 29 µM MCF7 -0.662 5508 5712 761 isoxicam 12 µM PC3 -0.663 7268 5713 695 picrotoxinin 14 µM MCF7 -0.663 4842 5714 1069 0198306-0000 10 µM PC3 -0.664 7069 5715 658 furazolidone 18 µM HL60 -0.664 3019 5716 651 gabapentin 23 µM HL60 -0.664 2731 5717 694 zalcitabine 19 µM MCF7 -0.665 4799 5718 731 pheneticillin 10 µM PC3 -0.665 5763 5719 1092 IC-86621 1 µM MCF7 -0.665 7543 5720 1061 SB-203580 1 µM MCF7 -0.665 6915 5721 730 neostigmine bro- 13 µM MCF7 -0.666 5335 mide 5722 43 tetraethylenepentamine10 µM MCF7 -0.666 405 5723 659 bretylium tosilate 10 µM HL60 -0.666 3057 5724 661 bacitracin 3 µM HL60 -0.666 3109 5725 1075 PHA-00846566E 10 µM PC3 -0.667 7086 5726 749 tropine 28 µM HL60 -0.668 6147 5727 112 benserazide 10 µM MCF7 -0.67 641 5728 689 selegiline 18 µM PC3 -0.67 4065 5729 8 tacrolimus 1 µM MCF7 -0.67 169 5730 747 Prestwick-689 10 µM MCF7 -0.67 7173 5731 683 CP-320650-01 1 µM PC3 -0.671 3825 5732 1089 suramin sodium 10 µM PC3 -0.672 7529 5733 1073 AH-6809 1 µM PC3 -0.672 7075 5734 616 midodrine 14 µM PC3 -0.672 2087 5735 699 cefazolin 8 µM MCF7 -0.673 4708 5736 650 wortmannin 10 nM HL60 -0.674 2703 5737 660 altretamine 19 µM HL60 -0.674 3090 5738 753 metitepine 8 µM PC3 -0.675 6312 5739 688 Prestwick-864 35 µM PC3 -0.677 3994 5740 650 LY-294002 10 µM HL60 -0.678 2699 5741 746 cefuroxime 9 µM MCF7 -0.679 6261 5742 755 timolol 9 µM MCF7 -0.679 6483 5743 647 clopamide 12 µM MCF7 -0.68 3220 5744 704 3- 20 µM PC3 -0.68 4601 acetamidocoumarin 5745 694 diﬂunisal 16 µM MCF7 -0.68 4794

147 5746 715 N6- 14 µM PC3 -0.68 6732 methyladenosine 5747 756 bacitracin 3 µM MCF7 -0.681 6488 5748 713 thioperamide 10 µM PC3 -0.681 4675 5749 733 streptozocin 15 µM PC3 -0.682 5836 5750 699 mephenesin 22 µM MCF7 -0.683 4698 5751 698 trimethoprim 14 µM PC3 -0.683 7377 5752 677 bethanechol 20 µM MCF7 -0.684 3537 5753 680 guanadrel 8 µM PC3 -0.684 3698 5754 699 guanadrel 8 µM MCF7 -0.685 4720 5755 660 idazoxan 17 µM HL60 -0.686 3088 5756 708 iohexol 5 µM MCF7 -0.686 5704 5757 1083 CP-944629 10 µM PC3 -0.686 7502 5758 704 Prestwick-642 14 µM PC3 -0.687 4594 5759 671 clidinium bromide 9 µM MCF7 -0.687 3476 5760 758 serotonin 19 µM MCF7 -0.687 5633 5761 699 merbromin 5 µM MCF7 -0.687 4722 5762 693 cefalonium 9 µM PC3 -0.688 4245 5763 665 asiaticoside 4 µM HL60 -0.689 2943 5764 645 foliosidine 13 µM HL60 -0.689 2201 5765 661 atropine methoni- 11 µM HL60 -0.689 3116 trate 5766 744 pindolol 16 µM MCF7 -0.689 6834 5767 754 iproniazid 14 µM PC3 -0.689 6359 5768 630 ritodrine 12 µM HL60 -0.69 1280 5769 761 disopyramide 12 µM PC3 -0.69 7276 5770 650 fulvestrant 10 nM HL60 -0.69 2698 5771 673 pentetic acid 10 µM MCF7 -0.691 3387 5772 650 troglitazone 10 µM HL60 -0.691 2692 5773 602 acetylsalicylic acid 100 µM HL60 -0.692 1145 5774 1094 meteneprost 10 µM MCF7 -0.692 7552 5775 645 sulfachlorpyridazine 14 µM HL60 -0.692 2191 5776 691 trimethobenzamide 9 µM MCF7 -0.692 4180 5777 644 trihexyphenidyl 12 µM HL60 -0.693 2158 5778 631 carbarsone 15 µM HL60 -0.693 1313 5779 658 paromomycin 6 µM HL60 -0.693 3017 5780 733 cefotaxime 8 µM PC3 -0.693 5830 5781 764 midodrine 14 µM PC3 -0.693 7156 5782 646 lidoﬂazine 8 µM MCF7 -0.693 3201 5783 690 suprofen 15 µM MCF7 -0.693 4123 5784 649 ﬂecainide 8 µM HL60 -0.693 2557 5785 719 bethanechol 20 µM PC3 -0.694 5114

148 5786 703 santonin 16 µM PC3 -0.694 4531 5787 658 nafcillin 9 µM HL60 -0.694 2983 5788 617 tiratricol 6 µM PC3 -0.694 2096 5789 749 cefepime 7 µM HL60 -0.694 6159 5790 43 tetraethylenepentamine100 µM MCF7 -0.694 406 5791 1077 0316684-0000 10 µM PC3 -0.694 7098 5792 1083 suramin sodium 10 µM PC3 -0.694 7501 5793 677 cyclic adenosine 12 µM MCF7 -0.695 3531 monophosphate 5794 712 dehydrocholic acid 10 µM PC3 -0.695 4620 5795 687 nialamide 13 µM MCF7 -0.695 3871 5796 741 moracizine 9 µM MCF7 -0.696 6000 5797 705 Prestwick-692 7 µM MCF7 -0.696 4424 5798 705 3- 20 µM MCF7 -0.696 4426 acetamidocoumarin 5799 658 theophylline 20 µM HL60 -0.697 2986 5800 1051 H-89 500 nM MCF7 -0.697 6878 5801 644 protoveratrine A 5 µM HL60 -0.698 2144 5802 698 sulfadimethoxine 13 µM PC3 -0.698 7400 5803 623 nicardipine 8 µM HL60 -0.698 1600 5804 633 danazol 12 µM MCF7 -0.698 1538 5805 661 adipiodone 4 µM HL60 -0.698 3111 5806 632 cimetidine 16 µM MCF7 -0.698 1464 5807 761 triprolidine 13 µM PC3 -0.698 7248 5808 735 carbimazole 21 µM MCF7 -0.698 5399 5809 630 benzbromarone 9 µM HL60 -0.699 1291 5810 653 clebopride 8 µM MCF7 -0.699 2646 5811 1084 pioglitazone 10 µM MCF7 -0.7 7506 5812 634 glycocholic acid 9 µM HL60 -0.7 2454 5813 628 thiamphenicol 11 µM PC3 -0.7 1826 5814 660 oxybenzone 18 µM HL60 -0.701 3092 5815 733 diazoxide 17 µM PC3 -0.702 5810 5816 631 piperine 14 µM HL60 -0.702 1327 5817 617 mefexamide 13 µM PC3 -0.702 2121 5818 744 furosemide 12 µM MCF7 -0.702 6841 5819 631 Chicago Sky Blue 4 µM HL60 -0.703 1330 6B 5820 703 thiamazole 35 µM PC3 -0.703 4550 5821 685 PNU-0230031 1 µM MCF7 -0.703 3632 5822 619 clemastine 9 µM HL60 -0.703 2412 5823 673 bemegride 26 µM MCF7 -0.703 3389 5824 657 thiamine 12 µM MCF7 -0.703 2894

149 5825 683 CP-690334-01 1 µM PC3 -0.704 3826 5826 738 metampicillin 10 µM MCF7 -0.704 5540 5827 1040 Gly-His-Lys 1 µM PC3 -0.705 6570 5828 1041 PNU-0293363 10 µM MCF7 -0.705 6573 5829 715 adenosine phos- 11 µM PC3 -0.705 6760 phate 5830 673 hymecromone 23 µM MCF7 -0.706 3383 5831 655 methoxsalen 19 µM MCF7 -0.706 3302 5832 686 indapamide 11 µM MCF7 -0.706 3859 5833 658 iocetamic acid 7 µM HL60 -0.707 3022 5834 1095 meteneprost 10 µM PC3 -0.707 7557 5835 747 cefotaxime 8 µM MCF7 -0.708 7186 5836 737 isometheptene 8 µM MCF7 -0.709 5502 5837 658 nadolol 13 µM HL60 -0.71 3020 5838 735 clopamide 12 µM MCF7 -0.71 5402 5839 612 trimethobenzamide 9 µM HL60 -0.711 2002 5840 728 piretanide 11 µM PC3 -0.711 4490 5841 514 DL-PPMP 2 µM MCF7 -0.712 1121 5842 1077 AR-A014418 10 µM PC3 -0.712 7097 5843 703 CP-320650-01 1 µM PC3 -0.713 4560 5844 731 calycanthine 12 µM PC3 -0.713 5744 5845 735 cefoperazone 6 µM MCF7 -0.714 5424 5846 514 12,13-EODE 200 nM MCF7 -0.714 1108 5847 715 betamethasone 10 µM PC3 -0.714 6728 5848 693 Prestwick-967 26 µM PC3 -0.714 4250 5849 762 gliquidone 8 µM PC3 -0.714 7301 5850 631 metrizamide 5 µM HL60 -0.714 1318 5851 602 troglitazone 10 µM HL60 -0.715 1173 5852 699 calcium folinate 8 µM MCF7 -0.715 4725 5853 749 ciproﬁbrate 14 µM HL60 -0.715 6138 5854 630 hesperidin 7 µM HL60 -0.715 1294 5855 744 amrinone 21 µM MCF7 -0.716 6826 5856 618 hydralazine 20 µM HL60 -0.716 2349 5857 636 midodrine 14 µM MCF7 -0.717 2250 5858 767 sirolimus 100 nM MCF7 -0.717 6958 5859 683 phenelzine 17 µM PC3 -0.717 3802 5860 745 tranexamic acid 25 µM MCF7 -0.718 6238 5861 700 0179445-0000 1 µM MCF7 -0.718 4758 5862 700 isosorbide 17 µM MCF7 -0.718 4742 5863 615 mafenide 18 µM HL60 -0.718 1441 5864 629 mefenamic acid 17 µM HL60 -0.719 1863

150 5865 633 metolazone 11 µM MCF7 -0.719 1514 5866 657 tetracaine 13 µM MCF7 -0.72 2888 5867 662 racecadotril 10 µM MCF7 -0.72 2774 5868 752 terazosin 9 µM MCF7 -0.72 6092 5869 671 doxycycline 8 µM MCF7 -0.72 3479 5870 1095 BCB000040 10 µM PC3 -0.72 7559 5871 737 etofylline 18 µM MCF7 -0.721 5467 5872 628 acetazolamide 18 µM PC3 -0.721 1808 5873 733 ketotifen 9 µM PC3 -0.721 5842 5874 1040 alprostadil 10 µM PC3 -0.722 6571 5875 694 gabexate 10 µM MCF7 -0.722 4804 5876 632 lidocaine 15 µM MCF7 -0.722 1499 5877 655 pilocarpine 15 µM MCF7 -0.722 3300 5878 631 levothyroxine 5 µM HL60 -0.723 1312 sodium 5879 755 pipemidic acid 13 µM MCF7 -0.723 6470 5880 1084 16- 10 µM MCF7 -0.723 7505 phenyltetranorprostaglandin E2 5881 1091 fulvestrant 1 µM PC3 -0.724 7539 5882 619 homochlorcyclizine 10 µM HL60 -0.725 2386 5883 705 bacampicillin 8 µM MCF7 -0.725 4417 5884 741 heptaminol 22 µM MCF7 -0.726 6015 5885 645 diphenylpyraline 13 µM HL60 -0.726 2205 5886 644 yohimbic acid 11 µM HL60 -0.726 2147 5887 650 estradiol 10 nM HL60 -0.726 2701 5888 1094 BCB000040 10 µM MCF7 -0.728 7554 5889 690 metronidazole 23 µM MCF7 -0.729 4141 5890 755 etynodiol 10 µM MCF7 -0.73 6479 5891 761 levocabastine 9 µM PC3 -0.73 7249 5892 708 dimethadione 31 µM MCF7 -0.73 5668 5893 633 glipizide 9 µM MCF7 -0.73 1508 5894 719 metampicillin 10 µM PC3 -0.731 5115 5895 737 mafenide 18 µM MCF7 -0.731 5499 5896 648 propidium iodide 6 µM HL60 -0.732 2541 5897 1055 pioglitazone 10 µM MCF7 -0.733 6898 5898 747 streptomycin 3 µM MCF7 -0.733 7194 5899 630 3-hydroxy-DL- 18 µM HL60 -0.734 1300 kynurenine 5900 728 estropipate 9 µM PC3 -0.734 4472 5901 658 benzthiazide 9 µM HL60 -0.735 2989 5902 671 cromoglicic acid 8 µM MCF7 -0.735 3475

151 5903 735 metolazone 11 µM MCF7 -0.735 5392 5904 645 betonicine 25 µM HL60 -0.736 2207 5905 698 riluzole 15 µM PC3 -0.736 7365 5906 745 calycanthine 12 µM MCF7 -0.736 6221 5907 695 indoprofen 14 µM MCF7 -0.737 4832 5908 730 ergocalciferol 10 µM MCF7 -0.737 5346 5909 513 rosiglitazone 10 µM MCF7 -0.737 1071 5910 735 nitrendipine 11 µM MCF7 -0.738 5405 5911 632 sulfaguanidine 19 µM MCF7 -0.738 1495 5912 741 netilmicin 3 µM MCF7 -0.738 6005 5913 632 metronidazole 23 µM MCF7 -0.739 1503 5914 749 sertaconazole 8 µM HL60 -0.739 6128 5915 655 ceforanide 8 µM MCF7 -0.739 3309 5916 719 rilmenidine 8 µM PC3 -0.739 5107 5917 619 chenodeoxycholic 10 µM HL60 -0.74 2402 acid 5918 634 carbimazole 21 µM HL60 -0.74 2437 5919 645 etiocholanolone 14 µM HL60 -0.741 2204 5920 731 (+)-chelidonine 11 µM PC3 -0.741 5760 5921 678 mesalazine 26 µM MCF7 -0.742 3584 5922 690 levobunolol 12 µM MCF7 -0.743 4134 5923 663 Prestwick-692 7 µM MCF7 -0.744 2820 5924 664 3- 20 µM HL60 -0.744 2941 acetamidocoumarin 5925 654 pepstatin 6 µM MCF7 -0.745 3264 5926 657 clorsulon 11 µM MCF7 -0.745 2884 5927 662 convolamine 12 µM MCF7 -0.745 2771 5928 1041 Gly-His-Lys 1 µM MCF7 -0.745 6575 5929 678 tropine 28 µM MCF7 -0.746 3569 5930 631 carisoprodol 15 µM HL60 -0.746 1314 5931 665 bethanechol 20 µM HL60 -0.747 2975 5932 719 ﬂucloxacillin 8 µM PC3 -0.749 5102 5933 751 lycorine 12 µM MCF7 -0.75 6051 5934 661 isometheptene 8 µM HL60 -0.75 3145 5935 644 sulmazole 14 µM HL60 -0.75 2153 5936 767 estradiol 10 nM MCF7 -0.75 6957 5937 640 piracetam 28 µM HL60 -0.75 1710 5938 758 thioperamide 10 µM MCF7 -0.751 5635 5939 665 moracizine 9 µM HL60 -0.751 2959 5940 633 ampicillin 10 µM MCF7 -0.751 1530 5941 719 cyclizine 13 µM PC3 -0.751 5100 5942 747 iopamidol 5 µM MCF7 -0.753 7189

152 5943 681 isosorbide 17 µM PC3 -0.753 3720 5944 735 arecoline 17 µM MCF7 -0.754 5423 5945 747 streptozocin 15 µM MCF7 -0.754 7193 5946 641 cytisine 21 µM HL60 -0.754 1766 5947 631 SR-95531 11 µM HL60 -0.754 1316 5948 1081 CP-319743 10 µM PC3 -0.754 7491 5949 707 bemegride 26 µM MCF7 -0.755 5014 5950 648 benzethonium chlo- 9 µM HL60 -0.756 2508 ride 5951 727 valproic acid 1 mM PC3 -0.757 4433 5952 744 metoprolol 6 µM MCF7 -0.758 6846 5953 654 carteolol 12 µM MCF7 -0.758 3276 5954 673 2- 23 µM MCF7 -0.759 3400 aminobenzenesulfonamide 5955 737 dapsone 16 µM MCF7 -0.761 5498 5956 732 tropine 28 µM PC3 -0.764 5790 5957 628 heptaminol 22 µM PC3 -0.766 1825 5958 677 levopropoxyphene 7 µM MCF7 -0.766 3543 5959 635 colistin 3 µM HL60 -0.767 2491 5960 642 prilocaine 16 µM MCF7 -0.767 2314 5961 665 loracarbef 11 µM HL60 -0.769 2970 5962 636 ampyrone 20 µM MCF7 -0.771 2249 5963 695 iodixanol 3 µM MCF7 -0.772 4848 5964 662 stachydrine 22 µM MCF7 -0.772 2743 5965 648 ramifenazone 14 µM HL60 -0.774 2534 5966 676 cyclopenthiazide 11 µM MCF7 -0.774 7325 5967 654 Chicago Sky Blue 4 µM MCF7 -0.774 3266 6B 5968 719 cyclic adenosine 12 µM PC3 -0.775 5108 monophosphate 5969 720 lycorine 12 µM MCF7 -0.775 4365 5970 761 viomycin 5 µM PC3 -0.775 7278 5971 735 vigabatrin 31 µM MCF7 -0.78 5415 5972 628 epirizole 17 µM PC3 -0.781 1803 5973 506 estradiol 10 nM MCF7 -0.781 1021 5974 1053 AH-23848 1 µM MCF7 -0.781 6890 5975 704 prednisone 11 µM PC3 -0.782 4577 5976 653 fusidic acid 7 µM MCF7 -0.782 2647 5977 726 3-hydroxy-DL- 18 µM MCF7 -0.782 5276 kynurenine 5978 677 quinpirole 16 µM MCF7 -0.782 3539 5979 733 triamcinolone 10 µM PC3 -0.783 5835 5980 637 tiratricol 6 µM MCF7 -0.783 2259

153 5981 746 butamben 21 µM MCF7 -0.784 6266 5982 645 benzamil 11 µM HL60 -0.785 2200 5983 658 theobromine 22 µM HL60 -0.786 2995 5984 703 parbendazole 16 µM PC3 -0.786 4535 5985 633 baclofen 19 µM MCF7 -0.787 1536 5986 631 SR-95639A 10 µM HL60 -0.788 1336 5987 764 pyrithyldione 24 µM PC3 -0.788 7153 5988 678 thiethylperazine 6 µM MCF7 -0.788 3576 5989 661 halofantrine 7 µM HL60 -0.79 3130 5990 771 telenzepine 9 µM MCF7 -0.791 7419 5991 656 R-atenolol 15 µM MCF7 -0.791 2855 5992 1081 fulvestrant 1 µM PC3 -0.791 7495 5993 704 bicuculline 11 µM PC3 -0.791 4574 5994 665 spaglumic acid 13 µM HL60 -0.792 2962 5995 677 Prestwick-1083 9 µM MCF7 -0.793 3538 5996 694 minoxidil 19 µM MCF7 -0.793 4800 5997 663 conessine 11 µM MCF7 -0.793 2792 5998 695 letrozole 14 µM MCF7 -0.793 4824 5999 632 trimethobenzamide 9 µM MCF7 -0.794 1502 6000 645 ﬁnasteride 11 µM HL60 -0.795 2206 6001 603 tretinoin 1 µM PC3 -0.795 1211 6002 635 atovaquone 11 µM HL60 -0.795 2480 6003 650 rosiglitazone 10 µM HL60 -0.796 2693 6004 665 phensuximide 21 µM HL60 -0.797 2960 6005 706 acebutolol 11 µM MCF7 -0.798 4976 6006 602 rosiglitazone 10 µM HL60 -0.799 1174 6007 632 sulfathiazole 16 µM MCF7 -0.8 1463 6008 735 dinoprost 8 µM MCF7 -0.8 5409 6009 670 calcium folinate 8 µM MCF7 -0.8 3442 6010 672 levobunolol 12 µM MCF7 -0.802 3354 6011 631 cyclobenzaprine 13 µM HL60 -0.802 1332 6012 676 sotalol 13 µM MCF7 -0.804 7338 6013 676 epitiostanol 13 µM MCF7 -0.804 7342 6014 665 penbutolol 6 µM HL60 -0.806 2972 6015 687 lycorine 12 µM MCF7 -0.807 3891 6016 676 harpagoside 8 µM MCF7 -0.809 7355 6017 738 isoﬂupredone 10 µM MCF7 -0.809 5545 6018 736 proxymetacaine 12 µM MCF7 -0.812 5433 6019 655 dinoprost 8 µM MCF7 -0.812 3308 6020 644 vitexin 9 µM HL60 -0.813 2155 6021 656 trimethadione 28 µM MCF7 -0.815 2846

154 6022 650 sirolimus 100 nM HL60 -0.816 2702 6023 677 Prestwick-1082 12 µM MCF7 -0.817 3530 6024 719 sulindac 11 µM PC3 -0.818 5103 6025 736 naproxen 17 µM MCF7 -0.818 5457 6026 672 arcaine 15 µM MCF7 -0.819 3349 6027 737 gemﬁbrozil 16 µM MCF7 -0.82 5488 6028 741 pentoxifylline 14 µM MCF7 -0.821 6021 6029 618 fenbufen 16 µM HL60 -0.821 2346 6030 743 chlortalidone 12 µM MCF7 -0.822 6800 6031 744 estropipate 9 µM MCF7 -0.822 6808 6032 747 sulfamonomethoxine 14 µM MCF7 -0.824 7200 6033 687 tinidazole 16 µM MCF7 -0.825 3896 6034 649 merbromin 5 µM HL60 -0.827 2577 6035 678 chloropyrazine 35 µM MCF7 -0.827 3570 6036 673 bretylium tosilate 10 µM MCF7 -0.828 3394 6037 676 decamethonium 10 µM MCF7 -0.829 7353 bromide 6038 705 naringenin 15 µM MCF7 -0.829 4422 6039 665 netilmicin 3 µM HL60 -0.83 2963 6040 623 zaprinast 15 µM HL60 -0.83 1611 6041 733 isoniazid 29 µM PC3 -0.83 5840 6042 749 ondansetron 12 µM HL60 -0.832 6153 6043 634 serotonin 19 µM HL60 -0.833 2449 6044 761 meclofenamic acid 12 µM PC3 -0.833 7280 6045 602 estradiol 10 nM HL60 -0.834 1182 6046 1081 15(S)-15- 10 µM PC3 -0.837 7494 methylprostaglandin E2 6047 670 merbromin 5 µM MCF7 -0.837 3439 6048 647 adenosine phos- 11 µM MCF7 -0.839 3237 phate 6049 663 yohimbic acid 11 µM MCF7 -0.839 2803 6050 751 Prestwick-675 10 µM MCF7 -0.839 6042 6051 676 alprostadil 11 µM MCF7 -0.84 7358 6052 672 paromomycin 6 µM MCF7 -0.84 3356 6053 662 cinchonidine 14 µM MCF7 -0.842 2772 6054 649 atractyloside 5 µM HL60 -0.844 2573 6055 677 prednicarbate 8 µM MCF7 -0.846 3542 6056 631 dl-alpha tocopherol 9 µM HL60 -0.848 1320 6057 662 epivincamine 11 µM MCF7 -0.849 2775 6058 645 chlorcyclizine 12 µM HL60 -0.849 2197 6059 706 arcaine 15 µM MCF7 -0.85 4974

155 6060 676 3- 20 µM MCF7 -0.851 7361 acetamidocoumarin 6061 749 meprylcaine 15 µM HL60 -0.851 6123 6062 634 biperiden 11 µM HL60 -0.852 2460 6063 634 niridazole 19 µM HL60 -0.855 2440 6064 748 mesalazine 26 µM MCF7 -0.856 7241 6065 663 palmatine 10 µM MCF7 -0.856 2795 6066 637 pyrantel 11 µM MCF7 -0.858 2260 6067 1067 0316684-0000 10 µM PC3 -0.859 7057 6068 677 pivmecillinam 8 µM MCF7 -0.86 3535 6069 645 solasodine 10 µM HL60 -0.86 2170 6070 761 adiphenine 11 µM PC3 -0.861 7279 6071 634 ceforanide 8 µM HL60 -0.861 2447 6072 629 triﬂupromazine 10 µM HL60 -0.87 1855 6073 672 (+/-)-catechin 14 µM MCF7 -0.87 3351 6074 746 demecarium bro- 6 µM MCF7 -0.872 6269 mide 6075 661 trapidil 19 µM HL60 -0.872 3136 6076 644 sulfabenzamide 14 µM HL60 -0.873 2159 6077 771 enalapril 8 µM MCF7 -0.877 7428 6078 735 nimodipine 10 µM MCF7 -0.877 5421 6079 771 diethylcarbamazine 10 µM MCF7 -0.881 7425 6080 690 amiprilose 12 µM MCF7 -0.882 4119 6081 644 harman 18 µM HL60 -0.883 2150 6082 662 yohimbine 10 µM MCF7 -0.883 2755 6083 665 pivmecillinam 8 µM HL60 -0.884 2973 6084 631 betulinic acid 9 µM HL60 -0.886 1345 6085 771 bumetanide 11 µM MCF7 -0.887 7440 6086 634 pirenperone 10 µM HL60 -0.887 2455 6087 706 Chicago Sky Blue 4 µM MCF7 -0.89 4971 6B 6088 672 theobromine 22 µM MCF7 -0.893 3334 6089 765 estradiol 10 nM MCF7 -0.899 7000 6090 1083 meteneprost 10 µM PC3 -0.902 7504 6091 657 harmol 16 µM MCF7 -0.909 2900 6092 634 ergocalciferol 10 µM HL60 -0.914 2442 6093 676 methyldopate 15 µM MCF7 -0.914 7360 6094 665 cyclic adenosine 12 µM HL60 -0.918 2969 monophosphate 6095 665 Prestwick-1103 20 µM HL60 -0.919 2978 6096 665 lansoprazole 11 µM HL60 -0.952 2967 6097 632 amylocaine 15 µM MCF7 -0.957 1491 6098 649 diethylstilbestrol 15 µM HL60 -0.969 2567

156 6099 619 acemetacin 10 µM HL60 -0.974 2411 6100 1064 6-bromoindirubin- 500 nM MCF7 -1 7044 3’-oxime

157