Animal Models of Obesity and Diabetes Mellitus
UC Davis UC Davis Previously Published Works Title Animal models of obesity and diabetes mellitus. Permalink https://escholarship.org/uc/item/3z3879vp Journal Nature reviews. Endocrinology, 14(3) ISSN 1759-5029 Authors Kleinert, Maximilian Clemmensen, Christoffer Hofmann, Susanna M et al. Publication Date 2018-03-01 DOI 10.1038/nrendo.2017.161 Peer reviewed eScholarship.org Powered by the California Digital Library University of California REVIEWS Animal models of obesity and diabetes mellitus Maximilian Kleinert1–4, Christoffer Clemmensen1–3, Susanna M. Hofmann3,5,6, Mary C. Moore7, Simone Renner3,8, Stephen C. Woods9, Peter Huypens3,10, Johannes Beckers3,10,11, Martin Hrabe de Angelis3,10,11, Annette Schürmann3,12, Mostafa Bakhti3,5,13, Martin Klingenspor14,15,16, Mark Heiman17, Alan D. Cherrington7, Michael Ristow18, Heiko Lickert3,5,13, Eckhard Wolf3,8, Peter J. Havel19, Timo D. Müller1–3 and Matthias H. Tschöp1–3 Abstract | More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models. On the current trajectory, over half of the adult pop- To tackle these objectives, researchers rely on diverse ani- ulation in the United States will be obese by 2030, and mal models that span multiple species and strategic scien- similar increments are likely to occur in other developed tific approaches.
[Show full text]