US 2013 O156711A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0156711 A1 Castro (43) Pub. Date: Jun. 20, 2013

(54) TOPICAL SKIN CARE FORMULATION (52) U.S. Cl. CPC ...... A61K 8/375 (2013.01); A61O 19/08 (71) Applicant: Mary Kay Inc., Dallas, TX (US) (2013.01) USPC ...... 424/59 (72) Inventor: Mauricio Castro, Carrolton, TX (US) (73) Assignee: Mary Kay Inc., Dallas, TX (US) (57) ABSTRACT (21) Appl. No.: 13/707, 176 Disclosed is a topical skin care composition, and method for its use, that includes 55 to 65% by weight of water, 15 to 20% (22) Filed: Dec. 6, 2012 by weight of a combination of 3,3,5-Trimethylcyclohexyl O O 2-hydroxybenzoate (homosalate), 1-(4-Methoxyphenyl)-3- Related U.S. Application Data (4-tert-butylphenyl)propane-1,3-dione (avobenzone), 2-eth (60) Provisional application No. 61/567,970, filed on Dec. ylhexyl 2-hydroxybenzoate (Octisalate), and 2-ethylhexyl 7, 2011. 2-cyano-3,3-diphenyl-2-propenoate (octocrylene), 3 to 4% by weight of distearlydimonium chloride, and 1 to 3% by Publication Classification weight of a combination of euterpe oleracea fruit extract, punica granatum sterols, caprooyltetrapeptide-3, tocopherol (51) Int. Cl. or tocopherol acetate, and niacinamide, wherein the compo A6 IK S/37 (2006.01) sition has a sun protection factor of at least 15 or about 15 to A61O 19/08 (2006.01) US 2013/0156711 A1 Jun. 20, 2013

TOPCAL SKN CARE FORMULATION Zoic acid (PABA), PABA esters (glyceryl PABA, amyldim ethyl PABA and octyldimethyl PABA), butyl PABA, ethyl CROSS REFERENCE TO RELATED PABA, ethyl dihydroxypropyl PABA, cinnamates (octyl APPLICATIONS methoxycinnamate, isoamyl p-methoxycinnamate, octyl 0001. This application claims the benefit of U.S. Provi methoxy cinnamate, cinoxate, diisopropyl methyl cinnamate, sional Application No. 61/567,970, filed Dec. 7, 2011. The DEA-methoxycinnamate, ethyl diisopropylcinnamate, glyc contents of the referenced application are incorporated by eryl octanoate dimethoxycinnamate and ethyl methoxycin namate), cinnamate esters, homomethyl salicylate, benzyl reference. salicylate, glycol salicylate, isopropylbenzyl salicylate, BACKGROUND OF THE INVENTION anthranilates, ethyl urocanate, octyl triaZone, digalloy tri oleate, glyceryl aminobenzoate, lawsone with dihydroxyac 0002 A. Field of the Invention etone, ethylhexyl triaZone, dioctyl butamido triaZone, ben 0003. The present invention relates generally to topical Zylidene malonate polysiloxane, terephthalylidene skin care compositions. dicamphor Sulfonic acid, disodium phenyl dibenzimidazole 0004 B. Description of Related Art tetrasulfonate, diethylamino hydroxybenzoyl hexyl ben 0005 Ageing, chronic exposure to adverse environmental Zoate, bis diethylamino hydroxybenzoyl benzoate, bis ben factors, malnutrition, fatigue, etc., can change the visual Zoxazoylphenyl ethylhexylimino triazine, drometrizole trisi appearance, physical properties, or physiological functions of loxane, methylene bis-benzotriazolyl skin in ways that are considered visually undesirable. tetramethylbutylphenol, bis-ethylhexyloxyphenol methox Examples of Such changes include reduced skin elasticity, yphenyltriazine, 4-methylbenzylidenecamphor, and isopen reduced skin firmness, increased sagging of the skin, devel tyl 4-methoxycinnamate, etc.). The composition can also opment of lines and wrinkles, development of pits or nodules include a dermatologically acceptable vehicle which imparts in skin, development of age spots, dry skin, etc. Current a non-greasy feel when applied to skin. In particular embodi products on the market either do not provide a sufficient ments, the composition includes at least 50%, 55%, 60%, treatment option or require a multitude of different composi 65%, 70%, 75%, 80%, 85%, 90%, or more w/w of water. In tions to treat these physiological changes to skin. certain aspects, the composition can include 1 to 3% w/w of the total combination of skin active ingredients, 15 to 20% SUMMARY OF THE INVENTION w/w of the total combination of sunscreen agents, and 3 to 4% 0006. The present invention provides an effective solution by weight of a cationic surfactant (e.g., distearyldimonium to skin exhibiting reduced elasticity, reduced firmness, chloride), and/or 5 to 10% by weight of moisturizing agents increased sagginess, dryness, flakiness, fine lines and (e.g., glycerin, butyrospermum parkii, etc.). In other aspects, wrinkles, pits or nodules, damage caused by ultraviolet radia the composition can include 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10%, tion, age spots, uneven skin, etc. In one aspect of the present or more of the total combination of skin active ingredients, 1. invention, the Solution is topical application of a composition 2,3,4,5,6,7,8,9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20%, to skin in need of treatment. The skin can be in the décolleté or more of the total combination of Sunscreen agents, 1, 2, 3, 4, 5, 6,7,8,9, 10%, or more of a cationic surfactant, and/or 1, region (e.g., neck, shoulders, and/or upper chest), facial skin, 2,3,4,5,6,7,8,9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 29%, and/or body skin (e.g., arms, hands, chest, abdomen, upper or more by weight of moisturizing agents. The composition and lower back, legs, buttocks, feet, etc.) of a human. In can be fragrance-free in that it does not have a discernable particular embodiments, the skin can be in the décolleté odor. The composition can include a combination of odor region and/or hands. The composition can include a combi neutralizing ingredients, which can help produce a fragrance nation of skin active ingredients, wherein the skin active free composition. In particular aspects, the combination of ingredients include euterpe oleracea fruit extract, punica odor neutralizing ingredients includes at least 1, 2, 3, 4, 5, or granatum sterols, caprooyltetrapeptide-3, tocopherol ortoco all 6 of the following: ethylene brassylate, isobutyl methyl pherol acetate, or niacinamide, or any combination thereof, or all of these ingredients. The composition can also include a tetrahydropyranol; methyl linalool; methylenedioxyphenyl combination of skin moisturizing agents, wherein the mois methylpropanal; phenylisohexanol; and cyclamen aldehyde. turizing agents include glycerin or butyrospermum parkii or In certain aspects, the composition has a viscosity ranging both. The composition can also include a photo stable com from 20,000 cps to 500,00 cps, as measured on a Brookfield bination of Sunscreen agents providing the composition with Viscometer using a TC spindle at 2.5 rpm at 25°C. (or any a sun protection factor (SPF) of at least about 15 or about 15 range or integer therein—e.g., 30,000, 40,000, 50,000, to 20. Photo-stable refers to the ability of the composition to 60,000, 70,000, 80,000, 90,000, 100,000, 110,000, 120,000, maintain an SPF of at least about 15 for a sufficient period of 130,000, 140,000, 150,000, 160,000, 170,000, 180,000, 190, time after exposure to UV rays such as from the sun. In 000, 200,000, 250,000, 300,000, 400,000, 450,000, 475,000, particular embodiments, the Sunscreen agents include 3.3.5- etc.). In certain aspects, the composition is formulated a Trimethylcyclohexyl 2-hydroxybenzoate (homosalate), 1-(4- cream. The cream can be an oil-in-water emulsion. The com Methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3-dione position can be a multi-functional composition capable of (avobenzone), 2-ethylhexyl 2-hydroxybenzoate (octisalate), hydrating skin, increasing the firmness of skin, reducing the and/or 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate (oc appearance of fine lines or wrinkles on skin, and reducing the tocrylene). In some instances, the composition does not appearance of age spots on skin. include Sunscreen agents such as anyone of or all of 2-Hy 0007. The plant extracts (e.g., euterpe oleracea, punica droxy-4-methoxyphenyl)-phenylmethanone (oxybenzone), granatum, etc.) identified throughout this specification can be physical Sunscreen agents (e.g., kaoline, talc, petrolatum, obtained from any part of the plant. Non-limiting examples titanium oxide, titanium dioxide, Zinc oxide, etc.) and/or include extracts obtain from the whole plant, leaves, stems, additional chemical Sunscreen agents (e.g., para-aminoben flowers, flower buds, bark, roots, fruit, seeds, and any mixture US 2013/0156711 A1 Jun. 20, 2013

of such parts. By way of example, the extract can be obtained having fine lines and wrinkles, or skin pits or nodules com from the whole fruit (e.g., fruit pulp and seeds), the whole prising topically applying to the skin any one of the compo plant (e.g., the entire plant is used to produce the extract), a sitions disclosed throughout this specification. particular part of the plant at the exclusion of another part 0015. Also disclosed is a method of reducing free-radical (e.g., seed extract isolated from other parts of the plant), etc. damage in skin or reducing oxidation of skin cells while also The extract can be water-based, alcohol-based, oil-based, moisturizing skin. The method can include applying any one gel-based etc. of the compositions of the present invention to skin in need of 0008. In particular aspects, the compositions can be for Such treatment. mulated as emulsions (e.g., oil-in-water, water-in-oil, sili 0016. In other aspects, any one of the compositions dis cone-in-water, water-in-silicone, water-in-oil-in-water, oil closed throughout this specification can be used to treat or in-water, oil-in-water-in-oil, oil-in-water-in-silicone, etc.), prevent a wide variety of skin conditions (in addition to those creams, lotions, Solutions (e.g., aqueous or hydro-alcoholic previously mentioned). Non-limiting examples of skin con Solutions), anhydrous bases (e.g., lipstick or a powder), gels, ditions include pruritus, spider veins, lentigo, age spots, ointments, milks, pastes, aerosols, Solid forms, eye jellies, senile purpura, keratosis, melasma, blotches, fine lines or etc. The compositions can also be formulated for topical skin wrinkles, nodules, Sun damaged skin, dermatitis (including, application at least 1, 2, 3, 4, 5, 6, 7, or more times a day but not limited to seborrheic dermatitis, nummular dermatitis, during use. In other aspects of the present invention, compo contact dermatitis, atopic dermatitis, exfoliative dermatitis, sitions can be storage stable or color stable, or both. perioral dermatitis, and stasis dermatitis), psoriasis, follicu 0009. The compositions of the present invention can also litis, rosacea, acne, impetigo, erysipelas, erythrasma, eczema, be modified to have a desired oxygen radical absorbance Sunburns, burned skin, open wounds, skin-inflammatory skin capacity (ORAC) value. In certain non-limiting aspects, the conditions, etc. In certain non-limiting aspects, the skin con compositions of the present invention or the plant extracts dition can be caused by exposure to UV light, age, irradiation, identified throughout this specification can be modified to chronic Sun exposure, environmental pollutants, air pollution, have an ORAC value per mg of at least about 1, 2, 3, 4, 5, 6, wind, cold, heat, chemicals, disease pathologies, Smoking, or 7,8,9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, lack of nutrition. As noted above, the skin can be in the 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 95, décolleté region (e.g., neck, shoulders, upper chest), facial 100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 2000, skin, and/or body skin (e.g., arms, chest, abdomen, upper and 3000, 4000, 5000, 6000, 7000, 8000, 9000, 10000, 15000, lower back, legs, buttocks, feet, etc.). The method can further 20000, 30000, 50000, 100000 or more or any range derivable comprise identifying a person in need of skin treatment. The therein. person can be a male or female. The age of the person can be 0010. The compositions in non-limiting aspects can have a at least 1,2,3,4,5,6,7,8,9, 10, 15, 20, 25, 30, 35, 40, 45, 50, pH of about 6 to about 9. In other aspects, the pH can be 1, 2, 55, 60, 65, 70, 75, 80, 85,90, 95, or more years old, or any 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14. range derivable therein. The method can also include topi 0011 Compositions of the present invention can have cally applying an amount effective to: increase the stratum UVA and UVB absorption properties. The compositions can corneum turnover rate of the skin; increase collagen synthesis have an sun protection factor (SPF) of 2, 3, 4, 56, 7, 8, 9, 10, in fibroblasts; increase cellular anti-oxidant defense mecha 11, 12, 13, 14, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, or more, nisms (e.g., exogenous additions of anti-oxidants can bolster, or any integer or derivative therein. The compositions can be replenish, or prevent the loss of cellular antioxidants such as Sunscreen lotions, sprays, or creams. catalase and glutathione in skin cells (e.g., keratinocytes, 0012. Also disclosed is a method of hydrating, increasing melanocytes, langerhans cells, etc.) which will reduce or the firmness, reducing the appearance of fine lines or prevent oxidative damage to the skin, cellular, proteins, and wrinkles, and/or reducing the appearance of age spots on skin lipids); inhibit melanin production in melanocytes; reduce or comprising topically applying to the skin in need thereof any prevent oxidative damage to skin (including reducing the one of the topical skin compositions disclosed in this speci amount lipid peroxides and/or protein oxidation in the skin). fication. The skin can be in the décolleté region (e.g., neck, 0017. In certain embodiments, compositions of the shoulders, and/or upper chest), facial skin, and/or body skin present invention can decrease the amount of internal oxida (e.g., arms, hands, chest, abdomen, upper and lower back, tion and/or external oxidative damage in a cell. In other legs, buttocks, feet, etc.). In particular embodiments, the skin aspects, the compositions can increase collagen synthesis in a can be in the décolleté region and/or hands. In certain embodi cell. The compositions can also reduce skin inflammation, ments, the composition is applied to dry skin, saggy skin, a Such as by reducing inflammatory cytokine production in a fine line or wrinkle, and/or an age spot (e.g., liver spots, cell. Non-limiting examples of Such cells include human epi discolored spots, a freckles, Sun spot, hyper-pigmented skin, dermal keratinocyte, human fibroblast dermal cell, human etc.). The method is capable of hydrating, increasing the melanocytes, three dimensional human cell-derived in vitro firmness, reducing the appearance of fine lines or wrinkles, tissue equivalents comprising human keratinocytes, human and reducing the appearance of age spots on hand or neck skin fibroblasts, or human melanocytes, or any combination with a single composition. thereof (e.g., combination of human keratinocytes and human 0013 The compositions of the present invention can also fibroblasts or a combination of human keratinocytes and increase the integrity of the dermal-epidermal junction human melanocytes). (“DEJ). This method can stimulate the production of pro 0018. Also disclosed is a method of lightening skin or teins and enzymes in dermal and epidermal cells that aid in evening skin tone comprising applying the compositions of connecting the dermal layer to the epidermal layer. the present invention to the skin. The method can further 0014. In another embodiment there is disclosed a method comprise identify a person in need of lightening skin or of stimulating dermal or epidermal cellular activity in sagging evening skintone. The methods can further include inhibiting skin, skin that has reduced elasticity or reduced firmness, skin melanogenesis in a skin cell, inhibiting tyrosinase or tyrosi US 2013/0156711 A1 Jun. 20, 2013 nase synthesis in a skin cell, or inhibiting melanin transport to 0026. The term “about' or “approximately' are defined as keratinocytes in a skin cell. The composition can act as an being close to as understood by one of ordinary skill in the art, alpha melanin stimulatory hormone antagonist. The compo and in one non-limiting embodiment the terms are defined to sition can even out pigmentation of the skin. In non-limiting be within 10%, preferably within 5%, more preferably within aspect, lightening skin can include reducing the appearance 1%, and most preferably within 0.5%. of an age spot, a skin discoloration, a freckle, a Sun spot, 0027. The terms “inhibiting or “reducing or any varia hyper-pigmented skin, etc., by topical application of the com tion of these terms, when used in the claims and/or the speci position to the age spot, a skin discoloration, a freckle, a Sun fication includes any measurable decrease or complete inhi spot, hyper-pigmented skin, etc. bition to achieve a desired result. 0019. It is also contemplated that the compositions of the 0028. The term “effective, as that term is used in the present invention can be included into food-based products specification and/or claims, means adequate to accomplish a (e.g., beverages, fortified water, energy drinks, nutritional desired, expected, or intended result. drinks, Solid foods, vitamins, Supplements, etc.) and pharma 0029. The use of the word “a” or “an when used in con ceutical products (e.g., pills, injectible solutions, drugs, etc.). junction with the term “comprising in the claims and/or the For instance, any one of any combination of or all of the specification may mean “one but it is also consistent with following ingredients can be included into a food-based or the meaning of"one or more.” “at least one.” and “one or more pharmaceutical product: euterpe oleracea fruit extract, punica than one.” granatum sterols, caprooyltetrapeptide-3, tocopherol ortoco 0030. The use of the term “or' in the claims is used to pherol acetate, or niacinamide. mean “and/or unless explicitly indicated to refer to alterna 0020 Kits that include the compositions of the present tives only or the alternatives are mutually exclusive, although invention are also contemplated. In certain embodiments, the the disclosure supports a definition that refers to only alter composition is comprised in a container. The container can be natives and “and/or.” a bottle, dispenser, or package. The container can dispense a 0031. The words “comprising (and any form of compris pre-determined amount of the composition. In certain ing, such as "comprise' and "comprises”), “having (and any aspects, the compositions is dispensed in a spray, dollop, or form of having, such as “have and “has'), “including' (and any form of including, such as “includes” and “include’) or liquid. The container can include indicia on its surface. The “containing (and any form of containing. Such as "contains' indicia can be a word, an abbreviation, a picture, or a symbol. and “contain’) are inclusive or open-ended and do not 0021. Also contemplated is a product comprising a com exclude additional, unrecited elements or method steps. position of the present invention. In non-limiting aspects, the 0032. The compositions of the present invention can com product can be a cosmetic product. The cosmetic product can prise, consist essentially of, or consist of the claimed ingre be those described in other sections of this specification or dients. In one aspect, compositions consisting essentially of those known to a person of skill in the art. Non-limiting the claimed ingredients excludes ingredients that would examples of products include a moisturizer, a cream, a lotion, materially affect a given compositions ability to firm skin, a skin softener, a foundation, a night cream, a lipstick, a increase the elasticity of skin, stimulate dermal or epidermal cleanser, a toner, a Sunscreen, a mask, an anti-aging product, cellular activity of skin to increase the connection between a deodorant, an antiperspirant, a perfume, a cologne, etc. the dermal and epidermal layers, reduce or prevent free 0022. It is contemplated that any embodiment discussed in radical damage or oxidative damage of skin, moisturize skin, this specification can be implemented with respect to any reduce or prevent dry skin or flaky skin, reduce the appear method or composition of the invention, and vice versa. Fur ance offine lines or wrinkles, and/or reduce the appearance of thermore, compositions of the invention can be used to age spots. In another aspect, compositions consisting essen achieve methods of the invention. tially of dermatologically acceptable vehicles excludes ingre 0023. In one embodiment, the topical skin compositions dients that would result in undue toxicity, incompatibility, of the current invention are pharmaceutically elegant. “Phar instability, allergic response, and the like, when applied to maceutically elegant describes a composition that has par skin. ticular tactile properties which feel pleasant on the skin (e.g., 0033. Other objects, features and advantages of the compositions that are not too watery or greasy, compositions present invention will become apparent from the following that have a silky texture, compositions that are non-tacky or detailed description. It should be understood, however, that Sticky, etc.). Pharmaceutically elegant can also relate to the the detailed description and the examples, while indicating creaminess or lubricity properties of the composition or to the specific embodiments of the invention, are given by way of moisture retaining properties of the composition. illustration only. Additionally, it is contemplated that changes 0024 “Keratinous tissue' includes keratin-containing lay and modifications within the spirit and scope of the invention ers disposed as the outermost protective covering of mam will become apparent to those skilled in the art from this mals and includes, but is not limited to, skin, hair and nails. detailed description. 0025. “Topical application” means to apply or spread a composition onto the Surface of keratinous tissue. “Topical DESCRIPTION OF ILLUSTRATIVE skin composition' includes compositions suitable for topical EMBODIMENTS application on keratinous tissue. Such compositions are typi 0034. In today's image conscious Society, people are con cally dermatologically-acceptable in that they do not have tinually looking for a product that can improve the visual undue toxicity, incompatibility, instability, allergic response, appearance of their skin. Often times, ageing, chronic expo and the like, when applied to skin. Topical skin care compo Sure to adverse environmental factors, malnutrition, fatigue, sitions of the present invention can have a selected viscosity etc., can change the visual appearance, physical properties, or to avoid significant dripping or pooling after application to physiological functions of skin in ways that are considered skin. visually undesirable. US 2013/0156711 A1 Jun. 20, 2013

0035 Typically, cosmetic compositions focus on improv seed extract, pericarp extract are also available for purchase, ing the visual appearance of facial skin at the exclusion of suppliers of which are listed in the CTFA Handbook. Supplies other skin that can be exposed to the same if not more adverse for tocopherol, tocopherol acetate, and niacinamide are com environmental factors. Such skin includes hand skin and skin mercially available through a wide range of Suppliers. in the décolleté region (e.g., neck, upper chest, and shoul Caprooyl tetrapeptide-3 is a four length amino acid peptide ders), which is oftentimes uncovered by clothing and not linked to caproic acid. This ingredient is commercially avail protected or treated with topical skin formulations. Com able through Atrium Innovations Inc. (Canada) under the bined ultraviolet (UV) light and adverse environmental expo trade name CHRONOLINETM. Sure of hand and décolleté skin makes such skin highly sus 0041. For the plant extracts, the inventors contemplate that ceptible to the visible signs of aging (e.g., loss of skin any part of the plant can be used to make the extract. Non elasticity, sagging skin, fine lines and wrinkles, age spots, limiting examples include extracts obtain from the whole etc.). plant, leaves, stems, flowers, flower buds, bark, roots, fruit, 0036. Accumulated exposure to UV radiation and envi seeds, and any mixture of Such parts. By way of example, the ronmental pollutants cause the breakdown of healthy col extract can be obtained from the whole fruit (e.g., fruit pulp lagen fibers and the production of abnormal elastin. Further, and seeds), the whole plant (e.g., the entire plant is used to UV rays can damage melanocytes (skin cells that produce produce the extract), a particular part of the plant at the pigment or melanin). Melanocytes, which are located in the exclusion of another part (e.g., seed extract isolated from skin's epidermis, produce to provide normal skin color. UV other parts of the plant), etc. The extract can be water-based, light exposure triggers the melanocytes to create darker pig alcohol-based, oil-based, gel-based etc. ment to protect the deeper skin layer, the dermis and the 0042. In addition to purchasing the plant extracts, a person Subcutaneous tissue. Once damage occurs, the affected mel of ordinary skill can also be able to isolate them by using any anocytes may not produce normal skin color. The melano Suitable method known in the art. In one non-limiting cytes stop producing the normal amount of pigment and cre example, the whole plant (or any part of the plant—e.g., ate extra pigment. The extra melanin results in random dark leaves, stems, bark, roots, fruit, flowers or flower buds, fruit, spots scattered on the damaged. Skin (e.g., age spots, which are seeds, seedpods, etc.) can be disrupted by mechanical means also referred to as Solar lentigines, liver spots, dark spots, which results in a puree. The puree can then be processed to brown spots, discolored spots, freckles, etc.). Age spots are be substantially free of impurities or undesired solids. The collections of melanin in the upper layer of the dermis, and are puree can then be poured into a shallow vessel and quickly evidence that free radical damage has occurred. Age spots exposed to low temperature, i.e., flash frozen, for example at typically develop in people with a fair complexion but can be -20°C. or lower, under a vacuum for removal of water con seen even in those with darker skin. tent (lyophilization). The resultant extract can then be used in 0037. The inventors discovered that a unique combination the compositions of the present invention. of skin active ingredients, moisturizing agents, Sunscreen agents, and a cationic Surfactant that can protect and hydrate B. Moisturization Agents the skin, revitalize and rebuild the supportive dermal matrix of skin, and reduce uneven pigmentation on the hands and in 0043. The inventors also discovered that a combination of the décolleté area. When this combination of ingredients is glycerin and butyrospermum parkii (shea butter) along with placed in a dermatologically acceptable vehicle, the end the above mentioned skin actives produces a stable composi result is a topical skin care composition that can treat or tion having excellent moisturization properties. Both glycerin prevent a wide range of skin conditions ranging from reduced and butyrospermum parkii (shea butter) are described in the elasticity, reduced firmness, increased sagginess, dryness, CTFA Handbook along with corresponding suppliers of such flakiness, fine lines and wrinkles, pits or nodules, damage ingredients. Additional moisturizing ingredients that can be caused by ultraviolet radiation, age spots, etc. This can be used with the compositions of the present invention are achieved in a single topical skin care composition. described below. 0038. These and other non-limiting aspects of the present invention are described in further detail below. C. Sunscreen Agents 0044 An additional discovery of the inventors is a com A. Skin Active Ingredients bination of Sunscreen agents that remain photo-stable when 0039) Skin active ingredients that can be used in the com used in combination with the skin actives, moisturizing positions of the present invention include (but are not limited agents, and dermatologically acceptable vehicle. This allows to) euterpe oleracea fruit extract, punica granatum extract, for a stable and prolonged period of protection from ultravio caprooyl tetrapeptide-3, tocopherol or tocopherol acetate, let rays after topical application to skin. The following com and/or niacinamide. In particular aspects, the punica grana bination works well with the compositions of the present tum extract can include punica granatum sterols. invention: 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate 0040. Descriptions of each of these ingredients can be (homosalate), 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl) found in the International Cosmetic Ingredient Dictionary propane-1,3-dione (avobenzone), 2-ethylhexyl 2-hydroxy and Handbook, 12" Edition (2008)(“CTFA Handbook”), the benzoate (octisalate), and/or 2-ethylhexyl 2-cyano-3,3- relevant pages of which are incorporated by reference. Fur diphenyl-2-propenoate (octocrylene). ther, the CTFA Handbook also provides a list of companies 0045. Additional sunscreen agents that can be used with that Supply these ingredients. By way of example, euterpe the compositions of the present invention are described oleracea fruit extract can be obtained from Amax Nutra below. Further, no other Sunscreen agents are even needed to Source (Eugene, Oreg. USA) or Assessa-Industria (Brazil). create the SPF 15 of the compositions of the present inven Punica granatum Sterols, can be obtained from Active Con tion. Therefore, although additional Sunscreen agents can be cepts (Lincolnton, N.C. USA). Punica granatum fruit extract, added, they also be excluded. US 2013/0156711 A1 Jun. 20, 2013

D. Cationic Surfactant 0.0325%, 0.0350%, 0.0375%, 0.04.00%, 0.0425%, 0.0450%, 0046. The inventor discovered that a particular cationic 0.0475%, 0.0500%, 0.0525%, 0.0550%, 0.0575%, 0.0600%, surfactant, distearyldimonium chloride, works well with the 0.0625%, 0.0650%, 0.0675%, 0.0700%, 0.0725%, 0.0750%, other components of the disclosed formulation. Distearyldi 0.0775%, 0.0800%, 0.0825%, 0.0850%, 0.0875%, 0.0900%, monium chloride is a quaternary ammonium salt that includes 0.0925%, 0.0950%, 0.0975%, 0.1000%, 0.1250%, 0.1500%, a nitrogen atom Substituted with two methyl groups and two 0.1750%, 0.2000%, 0.2250%, 0.2500%, 0.2750%, 0.3000%, octadecyl groups. It is a positively-charged Surfactant capable 0.3250%, 0.3500%, 0.3750%, 0.4000%, 0.4250%, 0.4500%, of reacting with negatively charged proteins on the skin. It is 0.4750%, 0.5000%, 0.5250%, 0.550%, 0.5750%, 0.6000%, commercially available from a wide range of Sources (see, 0.6250%, 0.6500%, 0.6750%, 0.7000%, 0.7250%, 0.7500%, e.g., International Cosmetic Ingredient Dictionary and Hand 0.7750%, 0.8000%, 0.8250%, 0.8500%, 0.8750%, 0.9000%, book, 12" Edition (2008), Volume 1, pages 900-901). For 0.925.0%, 0.9500%, 0.9750%, 1.0%, 1.1%, 1.2%, 1.3%, instance, Evonik Industries (Germany) offers this ingredient 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, under the trade name Varisoft TA100. 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, E. Dermatologically Acceptable Vehicle 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 0047. The aforementioned skin actives, moisturizing 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, agents, and Sunscreen agents can be combined in a dermato 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, logically acceptable vehicle, which results in a multi-benefi 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, cial composition that remains color stable, photo-stable, and 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4%, chemically stable. The following combination of ingredients 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%, 13%, 14%, was found to work well with the compositions of the present 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, invention: butylene glycol, cetyl alcohol; and glyceryl Stear 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, ate. 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% or 0048. The dermatologically acceptable vehicle can be more, or any range or integer derivable therein, of at least one made by simple mixing of the ingredients, while using an of any combination of, or all of the skin active ingredients, appropriate amount of heating to obtain a homogenous mix moisturization agents, Sunscreen agents, cationic Surfactant, ture. A non-limiting example of such a vehicle is disclosed in or any additional ingredients disclosed in this specification. In the Examples of this specification. Additionally, a person non-limiting aspects, the percentage of such ingredients can having ordinary skill in the formulations art can use appro be calculated by weight or volume of the total weight of the priate methods for making a dermatologically acceptable compositions. The concentrations can vary depending on the vehicle having the ingredients identified throughout the desired effect of the compositions or on the product into specification. which the compositions are incorporated. F. Compositions of the Present Invention 0051 2. Composition Vehicles 0049. 1. Combinations and Amounts of Ingredients 0.052 The compositions of the present invention can be 0050. It is contemplated that the compositions of the formulated into all types of vehicles. Non-limiting examples present invention can include any one of the skin active ingre of Suitable vehicles include emulsions (e.g., oil-in-water, dients, moisturization agents, Sunscreen agents, and/or cat water-in-oil, silicone-in-water, water-in-silicone, water-in ionic Surfactants, or any combination of these ingredients. oil-in-water, oil-in-water, oil-in-water-in-oil, oil-in-water-in The compositions can also include additional ingredients silicone, etc.), creams, lotions, Solutions (both aqueous and described throughout this specification. The concentrations hydro-alcoholic), anhydrous bases (such as lipsticks and of the skin actives, moisturization agents, Sunscreen agents, powders), gels, ointments, pastes, milks, liquids, aerosols, ingredients in the dermatologically acceptable vehicle, or any Solid forms, or eye jellies. Variations and other appropriate additional ingredients can vary. In non-limiting embodi vehicles will be apparent to the skilled artisan and are appro ments, for example, the compositions can include in their priate for use in the present invention. In certain aspects, the final form, for example, at least about 0.0001%, 0.0002%. concentrations and combinations of the ingredients can be 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, selected in Such a way that the combinations are chemically 0.0009%, 0.0010%, 0.0011%, 0.0012%, 0.0013%, 0.0014%, compatible and do not form complexes which precipitate 0.0015%, 0.0016%, 0.0017%, 0.0018%, 0.001.9%, 0.0020%, from the finished product. 0.0021%, 0.0022%, 0.0023%, 0.0024%, 0.0025%, 0.0026%, 0053. It is also contemplated that the skin actives, ingre 0.0027%, 0.0028%, 0.0029%, 0.0030%, 0.0031%, 0.0032%, dients, moisturization agents, Sunscreen agents, ingredients 0.0033%, 0.0034%, 0.0035%, 0.0036%, 0.0037%, 0.0038%, in the dermatologically acceptable vehicle, or any additional 0.0039%, 0.0040%, 0.0041%, 0.0042%, 0.0043%, 0.0044%, ingredients identified throughout this specification can be 0.0045%, 0.0046%, 0.0047%, 0.0048%, 0.0049%, 0.0050%, encapsulated for delivery to a target area such as skin. Non 0.0051%, 0.0052%, 0.0053%, 0.0054%, 0.0055%, 0.0056%, limiting examples of encapsulation techniques include the 0.0057%, 0.0058%, 0.0059%, 0.0060%, 0.0061%, 0.0062%, use of liposomes, vesicles, and/or nanoparticles (e.g., biode 0.0063%, 0.0064%, 0.0065%, 0.0066%, 0.0067%, 0.0068%, gradable and non-biodegradable colloidal particles compris 0.0069%, 0.0070%, 0.0071%, 0.0072%, 0.0073%, 0.0074%, ing polymeric materials in which the ingredient is trapped, 0.0075%, 0.0076%, 0.0077%, 0.0078%, 0.0079%, 0.0080%, encapsulated, and/or absorbed—examples include nano 0.0081%, 0.0082%, 0.0083%, 0.0084%, 0.0085%, 0.008.6%, spheres and nanocapsules) that can be used as delivery 0.0087%, 0.0088%, 0.0089%, 0.0090%, 0.0091%, 0.0092%, vehicles to deliver Such ingredients to skin (see, e.g., U.S. Pat. 0.0093%, 0.0094%, 0.0095%, 0.0096%, 0.0097%, 0.0098%, No. 6,387,398: U.S. Pat. No. 6,203,802; U.S. Pat. No. 5,411, 0.0099%, 0.0100%, 0.0200%, 0.0250%, 0.0275%, 0.0300%, 744: Kreuter 1988). US 2013/0156711 A1 Jun. 20, 2013

0054 3. Products composition Such as carboxylic acid polymers, crosslinked 0055. The compositions of the present invention can be polyacrylate polymers, polyacrylamide polymers, polysac incorporated into cosmetic products, food-based products charides, and gums), and silicone containing compounds (e.g., fortified water, energy drinks, nutritional drinks, Vita (e.g., silicone oils and polyorganosiloxanes). The following mins, Supplements, Solid foods), pharmaceutical products, provides specific non-limiting examples of some of the addi etc. Non-limiting examples of cosmetic products include tional ingredients that can be used with the compositions of hand treatment products, décolleté treatment products, Sun the present invention. less skin tanning products, hair products (e.g., shampoos, 0060) i. Additional Sunscreen Agents conditioners, colorants, dyes, bleaches, straighteners, and 0061 UV absorption agents that can be used in combina permanent wave products), fingernail products, moisturizing tion with the compositions of the present invention include creams, skin creams and lotions, softeners, day lotions, gels, chemical and physical Sunblocks. Non-limiting examples of ointments, foundations, night creams, lipsticks and lip balms, chemical Sunblocks that can be used include para-aminoben cleansers, toners, masks, deodorants, antiperspirants, exfoli Zoic acid (PABA), PABA esters (glyceryl PABA, amyldim ating compositions, shaving-related products (e.g., creams, ethyl PABA and octyldimethyl PABA), butyl PABA, ethyl “bracers' and aftershaves), pre-moistened wipes and wash PABA, ethyl dihydroxypropyl PABA, benzophenones (oxy cloths, tanning lotions, bath products such as oils, foot care benZone, Sulisobenzone, benzophenone, and benzophe products such as powders and sprays, skin colorant and make none-1 through 12), cinnamates (octyl methoxycinnamate, up products Such as foundations, blushes, rouges eye shadows isoamyl p-methoxycinnamate, octylmethoxy cinnamate, and lines, lip colors and mascaras, baby products (e.g., baby cinoxate, diisopropyl methyl cinnamate, DEA-methoxycin lotions, oils, shampoos, powders and wet wipes), and skin or namate, ethyl diisopropylcinnamate, glyceryl octanoate facial peel products. Additionally, the cosmetic products can dimethoxycinnamate and ethyl methoxycinnamate), cin be formulated as leave-on or rinse-off products. namate esters, salicylates (homomethyl salicylate, benzyl 0056 4. Additional Ingredients salicylate, glycol salicylate, isopropylbenzyl salicylate, etc.), 0057 Compositions of the present invention can include anthranilates, ethyl urocanate, homosalate, octisalate, diben additional ingredients. Non-limiting examples of additional Zoylmethane derivatives, octyl triaZone, digalloy trioleate, ingredients include cosmetic ingredients (both active and glyceryl aminobenzoate, lawsone with dihydroxyacetone, non-active) and pharmaceutical ingredients (both active and ethylhexyl triazone, dioctyl butamido triazone, benzylidene non-active). malonate polysiloxane, terephthalylidene dicamphor Sul 0058 a. Cosmetic Ingredients fonic acid, disodium phenyl dibenzimidazole tetrasulfonate, 0059. The CTFA Handbook describes a wide variety of diethylamino hydroxybenzoyl hexyl benzoate, bis diethy non-limiting cosmetic ingredients that can be used in the lamino hydroxybenzoyl benzoate, bis benzoxazoylphenyl context of the present invention. Examples of these ingredient ethylhexylimino triazine, drometrizole trisiloxane, methyl classes include: fragrances (artificial and natural), dyes and ene bis-benzotriazolyl tetramethylbutyiphenol, and bis-eth color ingredients (e.g., Blue 1, Blue 1 Lake, Red 40, titanium ylhexyloxyphenol methoxyphenyltriazine, 4-methylben dioxide, D&C blue no. 4, D&C green no. 5, D&C orange no. Zylidenecamphor, and isopentyl 4-methoxycinnamate. Non 4, D&C red no. 17, D&C red no. 33, D&C violet no. 2, D&C limiting examples of physical Sunblocks include, kaolin, talc, yellow no. 10, and D&C yellow no. 11), adsorbents, emulsi petrolatum and metal oxides (e.g., titanium dioxide and Zinc fiers, stabilizers, lubricants, solvents, moisturizers (includ oxide). Compositions of the present invention can have UVA ing, e.g., emollients, humectants, film formers, occlusive and UVB absorption properties. The compositions can have agents, and agents that affect the natural moisturization an Sun protection factor (SPF) of 2,3,4,5,6,7,8,9, 10, 11, 12, mechanisms of the skin), water-repellants, UV absorbers 13, 14, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90 or (physical and chemical absorbers such as paraaminobenzoic more, or any integer or derivative therein. acid (PABA) and corresponding PABA derivatives, tita 0062 ii. Additional Moisturizing Agents nium dioxide, Zinc oxide, etc.), essential oils, vitamins (e.g., 0063) Non-limiting examples of moisturizing agents that A, B, C, D, E, and K), trace metals (e.g., Zinc, calcium and can be used with the compositions of the present invention Selenium), anti-irritants (e.g., Steroids and non-steroidal anti include amino acids, chondroitin Sulfate, diglycerin, erythri inflammatories), botanical extracts (e.g., aloe Vera, chamo tol, fructose, glucose, glycerol polymers, glycol, 1.2.6-hex mile, cucumber extract, ginkgo biloba, ginseng, and rose anetriol, honey, hyaluronic acid, hydrogenated honey, hydro mary), anti-microbial agents, antioxidants (e.g., BHT), genated Starch hydrolysate, inositol, lactitol, maltitol, chelating agents (e.g., disodium EDTA and tetrasodium maltose, mannitol, natural moisturizing factor, PEG-15 EDTA), preservatives (e.g., methylparaben and propylpara butanediol, polyglyceryl Sorbitol, salts of pyrollidone car ben), pH adjusters (e.g., sodium hydroxide and citric acid), boxylic acid, potassium PCA, propylene glycol, Sodium glu absorbents (e.g., aluminum starch octenylsuccinate, kaolin, curonate, sodium PCA, Sorbitol. Sucrose, trehalose, urea, and corn starch, oat starch, cyclodextrin, talc, and Zeolite), skin xylitol. bleaching and lightening agents (e.g., hydroquinone and 0064. Other examples include acetylated lanolin, acety niacinamide lactate), humectants (e.g., propylene glycol, lated lanolin alcohol, acrylates/C10-30 alkyl acrylate cross butylene glycol, pentylene glycol, Sorbitol, urea, and mani polymer, acrylates copolymer, alanine, algae extract, aloe tol), exfoliants (e.g., alpha-hydroxyacids, and beta-hydroxy barbadensis, aloe-barbadensis extract, aloe barbadensis gel. acids such as lactic acid, glycolic acid, and salicylic acid; and althea officinalis extract, aluminum starch octenylsuccinate, salts thereof) waterproofing agents (e.g., magnesium/alumi aluminum Stearate, apricot (prunus armeniaca) kernel oil, num hydroxide Stearate), skin conditioning agents (e.g., aloe arginine, arginine aspartate, arnica montana extract, ascorbic extracts, allantoin, bisabolol, ceramides, dimethicone, hyalu acid, ascorbyl palmitate, aspartic acid, avocado (persea grat ronic acid, and dipotassium glycyrrhizate), thickening agents issima) oil, barium Sulfate, barrier sphingolipids, butyl alco (e.g., Substances which that can increase the Viscosity of a hol, beeswax, behenyl alcohol, beta-sitosterol, BHT, birch US 2013/0156711 A1 Jun. 20, 2013

(betula alba) bark extract, borage (borago officinalis) extract, PEG-5 soy sterol, PEG-10 soy sterol, PEG-2 stearate, PEG-8 2-bromo-2-nitropropane-1,3-diol, butcherbroom (ruscus stearate, PEG-20 stearate, PEG-32 stearate, PEG40 stearate, aculeatus) extract, butylene glycol, calendula officinalis PEG-50 stearate, PEG-100 stearate, PEG-150 stearate, pen extract, calendula officinalis oil, candelilla (euphorbia cer tadecalactone, peppermint (mentha piperita) oil, petrolatum, ifera) wax, canola oil, caprylic/capric triglyceride, cardamon phospholipids, polyamino Sugar condensate, polyglyceryl-3 (elettaria cardamomum) oil, carnauba (copernicia cerifera) disoStearate, polyduaternium-24, polysorbate 20, polysor bate 40, polysorbate 60, polysorbate 80, polysorbate 85. wax, carrageenan (chondrus crispus), carrot (daucus carota potassium myristate, potassium palmitate, potassium Sorbate, sativa) oil, castor (ricinus communis) oil, ceramides, ceresin, potassium Stearate, propylene glycol, propylene glycol dica ceteareth-5, ceteareth-12, ceteareth-20, cetearyl octanoate, prylate/dicaprate, propylene glycol dioctanoate, propylene ceteth-20, ceteth-24, cetyl acetate, cetyl octanoate, cetyl glycol dipelargonate, propylene glycol laurate, propylene palmitate, chamomile (anthemis nobilis) oil, cholesterol, glycol stearate, propylene glycol stearate SE, PVP. pyridox cholesterol esters, cholesteryl hydroxy Stearate, citric acid, ine dipalmitate, quaternium-15, quaternium-18 hectorite, clary (Salvia Sclarea) oil, cocoa (theobroma cacao) butter, quaternium-22, retinol, retinol palmitate, rice (oryza sativa) coco-caprylate/caprate, coconut (cocos nucifera) oil, col bran oil, RNA, rosemary (rosmarinus officinalis) oil, rose oil, lagen, collagen amino acids, corn (Zea mays)oil, fatty acids, safflower (carthamus tinctorius) oil, sage (salvia officinalis) decyl oleate, dextrin, diazolidinyl urea, dimethicone oil, Salicylic acid, Sandalwood (Santalum album) oil, serine, copolyol, dimethiconol, dioctyl adipate, dioctyl Succinate, serum protein, Sesame (sesamum indicum) oil, silk powder, dipentaerythritylhexacaprylate/hexacaprate, DMDM hydan Sodium chondroitin Sulfate, Sodium hyaluronate, Sodium lac toin, DNA, erythritol, ethoxydiglycol, ethyl linoleate, euca tate, Sodium palmitate, sodium PCA, sodium polyglutamate, lyptus globulus oil, evening primrose (oenothera biennis) oil, Sodium Stearate, soluble collagen, Sorbic acid, Sorbitan lau fatty acids, tructose, gelatin, geranium maculatum oil, glu rate, Sorbitan oleate, Sorbitan palmitate, Sorbitan sesqui cosamine, glucose glutamate, glutamic acid, glycereth-26, oleate, Sorbitan Stearate, Sorbitol, Soybean (glycine Soja) oil, glycerol, glyceryl distearate, glyceryl hydroxy Stearate, glyc sphingolipids, squalane, squalene, Stearamide MEA-stearate, eryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl Stearic acid, Stearoxy dimethicone, Stearoxytrimethylsilane, oleate, glyceryl Stearate, glyceryl Stearate SE, glycine, glycol Stearyl alcohol, Stearyl glycyrrhetinate, Stearyl heptanoate, Stearate, glycol Stearate SE, glycosaminoglycans, grape (vitis Stearyl Stearate, Sunflower (helianthus annuus) seed oil, Sweet Vinifera) seed oil, hazel (corylus americana) nut oil, hazel almond (prunus amygdalus dulcis) oil, synthetic beeswax, (corylus avellana) nut oil, hexylene glycol, honey, hyaluronic tocopheryl linoleate, tribehenin, tridecyl neopentanoate, acid, hybrid safflower (carthamus tinctorius) oil, hydroge nated castor oil, hydrogenated coco-glycerides, hydroge tridecyl Stearate, triethanolamine, tristearin, urea, vegetable nated coconut oil, hydrogenated lanolin, hydrogenated leci oil, water, waxes, wheat (triticum Vulgare) germ oil, and thin, hydrogenated palm glyceride, hydrogenated palm ylangylang (cananga odorata) oil. kernel oil, hydrogenated Soybean oil, hydrogenated tallow 0065 iii. Antioxidants glyceride, hydrogenated vegetable oil, hydrolyzed collagen, 0.066 Non-limiting examples of antioxidants that can be hydrolyzed elastin, hydrolyzed glycosaminoglycans, hydro used with the compositions of the present invention include lyzed keratin, hydrolyzed soy protein, hydroxylated lanolin, acetyl cysteine, ascorbic acid polypeptide, ascorbyl dipalmi hydroxyproline, imidazolidinyl urea, iodopropynylbutylcar tate, ascorbyl methylsilanol pectinate, ascorbyl palmitate, bamate, isocetyl Stearate, isocetyl Stearoyl Stearate, isodecyl ascorbyl stearate. BHA, BHT, t-butyl hydroquinone, cys oleate, isopropyl isostearate, isopropyl lanolate, isopropyl teine, cysteine HCI, diamylhydroquinone, di-t-butylhydro myristate, isopropyl palmitate, isopropyl Stearate, isosteara quinone, dicetyl thiodipropionate, dioleyl tocopheryl meth mide DEA, isostearic acid, isostearyl lactate, isostearyl neo ylsilanol, disodium ascorbyl Sulfate, distearyl pentanoate, jasmine (jasminum officinale) oil, jojoba (buxus thiodipropionate, ditridecyl thiodipropionate, dodecyl gal chinensis) oil, kelp, kukui (aleurites moluccana) nut oil, lac late, erythorbic acid, esters of ascorbic acid, ethyl ferulate, tamide MEA, laneth-16, laneth-10 acetate, lanolin, lanolin ferulic acid, gallic acid esters, hydroquinone, isooctyl acid, lanolin alcohol, lanolin oil, lanolin wax, lavender (la thioglycolate, kojic acid, magnesium ascorbate, magnesium vandula angustifolia) oil, lecithin, lemon (citrus medica ascorbyl phosphate, methylsilanol ascorbate, natural botani limonum) oil, linoleic acid, linolenic acid, macadamia terni cal anti-oxidants such as green tea or grape seed extracts, folia nut oil, magnesium Stearate, magnesium Sulfate, malti nordihydroguaiaretic acid, octyl gallate, phenylthioglycolic tol, matricaria (chamomilla recutita) oil, methylglucose ses acid, potassium ascorby1 tocopheryl phosphate, potassium quistearate, methylsilanol PCA, microcrystalline wax, Sulfite, propyl gallate, quinones, rosmarinic acid, sodium mineral oil, mink oil, mortierella oil, myristyl lactate, myri ascorbate, sodium bisulfite, sodium erythorbate, Sodium met styl myristate, myristylpropionate, neopentylglycol dicapry abisulfite, sodium Sulfite, Superoxide dismutase, Sodium late/dicaprate, octyldodecanol, octyldodecyl myristate, thioglycolate, Sorbityl furfural, thiodiglycol, thiodiglycola octyldodecyl Stearoyl Stearate, octyl hydroxyStearate, octyl mide, thiodiglycolic acid, thioglycolic acid, thiolactic acid, palmitate, octyl salicylate, octyl Stearate, oleic acid, olive thiosalicylic acid, tocophereth-5, tocophereth-10, toco (olea europaea) oil, orange (citrus aurantium dulcis) oil, palm phereth-12, tocophereth-18, tocophereth-50, tocophersolan, (elaeis guineensis) oil, palmitic acid, pantethine, panthenol, tocopheryllinoleate, tocopheryl nicotinate, tocopheryl Succi panthenyl ethyl ether, paraffin, PCA, peach (prunus persica) nate, and tris(nonylphenyl)phosphite. kernel oil, peanut (arachis hypogaea) oil, PEG-8 C12-18 0067 iv. Structuring Agents ester, PEG-15 cocamine, PEG-150 distearate, PEG-60 glyc 0068. In other non-limiting aspects, the compositions of eryl isostearate, PEG-5 glyceryl Stearate, PEG-30 glyceryl the present invention can include a structuring agent. Struc stearate, PEG-7 hydrogenated castor oil, PEG-40 hydroge turing agents, in certain aspects, assist in providing rheologi nated castor oil, PEG-60 hydrogenated castor oil, PEG-20 cal characteristics to the composition to contribute to the methyl glucose sesquistearate, PEG40 sorbitan peroleate, composition’s stability. In other aspects, structuring agents US 2013/0156711 A1 Jun. 20, 2013

can also function as an emulsifier or Surfactant. Non-limiting Ingredient Dictionary (incorporated by reference) as cyclic examples of structuring agents include Stearic acid, palmitic dimethyl polysiloxane compounds and a mixture of fully acid, Stearyl alcohol, cetyl alcohol, behenyl alcohol, Stearic methylated linear siloxane polymers end-blocked with trim acid, palmitic acid, the polyethylene glycol ether of Stearyl ethylsiloxy units, respectively. Other non-limiting volatile alcohol having an average of about 1 to about 21 ethylene silicone oils that can be used in the context of the present oxide units, the polyethylene glycol ether of cetyl alcohol invention include those available from General Electric Co., having an average of about 1 to about 5 ethylene oxide units, Silicone Products Div., Waterford, N.Y. and SWS Silicones and mixtures thereof Div. of Stauffer Chemical Co., Adrian, Mich. 0069 v. Emulsifiers 0074 vii. Essential Oils 0070. In some non-limiting aspects, the compositions can 0075 Essential oils include oils derived from herbs, flow include one or more emulsifiers. Emulsifiers can reduce the ers, trees, and other plants. Such oils are typically present as interfacial tension between phases and improve the formula tiny droplets between the plants cells, and can be extracted tion and stability of an emulsion. The emulsifiers can be by several method known to those of skill in the art (e.g., nonionic, cationic, anionic, and Zwitterionic emulsifiers (See steam distilled, enfleurage (i.e., extraction by using fat), mac McCutcheon's (1986); U.S. Pat. Nos. 5,011,681; 4,421,769: eration, solvent extraction, or mechanical pressing). When 3.755,560). Non-limiting examples include esters of glyc these types of oils are exposed to air they tend to evaporate erin, esters of propylene glycol, fatty acid esters of polyeth (i.e., a volatile oil). As a result, many essential oils are color ylene glycol, fatty acid esters of polypropylene glycol, esters less, but with age they can oxidize and become darker. Essen of sorbitol, esters of sorbitan anhydrides, carboxylic acid tial oils are insolubleinwater and are soluble in alcohol, ether, copolymers, esters and ethers of glucose, ethoxylated ethers, fixed oils (vegetal), and other organic solvents. Typical physi ethoxylated alcohols, alkyl phosphates, polyoxyethylene cal characteristics found in essential oils include boiling fatty ether phosphates, fatty acid amides, acyl lactylates, points that vary from about 160° to 240° C. and densities soaps, TEA stearate, DEA oleth-3 phosphate, polyethylene ranging from about 0.759 to about 1.096. glycol 20 sorbitan monolaurate (polysorbate 20), polyethyl 0076 Essential oils typically are named by the plant from ene glycol 5 soya sterol, Steareth-2, Steareth-20, Steareth-21, which the oil is found. For example, rose oil or peppermint oil ceteareth-20. PPG-2 methylglucose ether distearate, ceteth are derived from rose or peppermint plants, respectively. 10, polysorbate 80, cetyl phosphate, potassium cetyl phos Non-limiting examples of essential oils that can be used in the phate, diethanolamine cetyl phosphate, polysorbate 60, glyc context of the present invention include sesame oil, macad eryl Stearate, PEG-100 stearate, and mixtures thereof. amia nut oil, tea tree oil, evening primrose oil, Spanish sage 0071 vi. Silicone Containing Compounds oil, Spanish rosemary oil, coriander oil, thyme oil, pimento 0072. In non-limiting aspects, silicone containing com berries oil, rose oil, anise oil, balsam oil, bergamot oil, rose pounds include any member of a family of polymeric prod wood oil, cedar oil, chamomile oil, Sage oil, clary sage oil, ucts whose molecular backbone is made up of alternating clove oil, cypress oil, eucalyptus oil, fennel oil, Seafennel oil, silicon and oxygen atoms with side groups attached to the frankincense oil, geranium oil, ginger oil, grapefruit oil, jas silicon atoms. By varying the -Si-O-chain lengths, side mine oil, juniper oil, lavender oil, lemon oil, lemongrass oil, groups, and crosslinking, silicones can be synthesized into a lime oil, mandarin oil, marjoram oil, myrrh oil, neroli oil, wide variety of materials. They can vary in consistency from orange oil, patchouli oil, pepper oil, black pepper oil, petit liquid to gel to Solids. grain oil, pine oil, rose otto oil, rosemary oil, Sandalwood oil, 0073. The silicone containing compounds that can be used spearmint oil, spikenard oil, Vetiver oil, wintergreen oil, or in the context of the present invention include those described ylangylang. Other essential oils known to those of skill in the in this specification or those known to a person of ordinary art are also contemplated as being useful within the context of skill in the art. Non-limiting examples include silicone oils the present invention. (e.g., volatile and non-volatile oils), gels, and solids. In pre 0077 viii. Thickening Agents ferred aspects, the silicon containing compounds includes a 0078. Thickening agents, including thickener or gelling silicone oils such as a polyorganosiloxane. Non-limiting agents, include Substances that can increase the viscosity of a examples of polyorganosiloxanes include dimethicone, composition. Thickeners include those that can increase the cyclomethicone, polysilicone-11, phenyl trimethicone, trim Viscosity of a composition without Substantially modifying ethylsilylamodimethicone, Stearoxytrimethylsilane, or mix the efficacy of the active ingredient within the composition. tures of these and other organosiloxane materials in any given Thickeners can also increase the stability of the compositions ratio in order to achieve the desired consistency and applica of the present invention. tion characteristics depending upon the intended application 0079 Non-limiting examples of additional thickening (e.g., to a particular area such as the skin, hair, or eyes). A agents that can be used in the context of the present invention “volatile silicone oil includes a silicone oil have a low heat of include carboxylic acid polymers, crosslinked polyacrylate vaporization, i.e. normally less than about 50 cal per gram of polymers, polyacrylamide polymers, polysaccharides, and silicone oil. Non-limiting examples of volatile silicone oils gums. Examples of carboxylic acid polymers include include: cyclomethicones such as Dow Corning 344 Fluid, crosslinked compounds containing one or more monomers Dow Corning 345 Fluid, Dow Corning 244 Fluid, and Dow derived from acrylic acid, Substituted acrylic acids, and salts Corning 245 Fluid, Volatile Silicon 7207 (Union Carbide and esters of these acrylic acids and the Substituted acrylic Corp., Danbury, Conn.); low viscosity dimethicones, i.e. acids, wherein the crosslinking agent contains two or more dimethicones having a viscosity of about 50 cst or less (e.g., carbon-carbon double bonds and is derived from a polyhydric dimethicones such as Dow Corning 200-0.5 cst Fluid). The alcohol (see U.S. Pat. Nos. 5,087,445; 4,509,949; 2,798,053; Dow Corning Fluids are available from Dow Corning Corpo CTFA International Cosmetic Ingredient Dictionary, 4" Ed., ration, Midland, Michigan. Cyclomethicone and dimethicone 1991). Examples of commercially available carboxylic acid are described in the Third Edition of the CTFA Cosmetic polymers include carbomers, which are homopolymers of US 2013/0156711 A1 Jun. 20, 2013

acrylic acid crosslinked with allyl ethers of Sucrose or pen G. Kits taerytritol (e.g., CarbopolTM900 series from B. F. Goodrich). I0086 Kits are also contemplated as being used in certain 0080. Non-limiting examples of crosslinked polyacrylate aspects of the present invention. For instance, a composition polymers include cationic and nonionic polymers. Examples of the present invention can be included in a kit. A kit can are described in U.S. Pat. Nos. 5,100,660; 4,849,484; 4,835, include a container. Containers can include a bottle, a metal 206; 4,628,078; 4,599,379). tube, a laminate tube, a plastic tube, a dispenser, a pressurized 0081. Non-limiting examples of polyacrylamide poly container, a barrier container, a package, a compartment, a mers (including nonionic polyacrylamide polymers includ lipstick container, a compact container, cosmetic pans that ing Substituted branched or unbranched polymers) include can hold cosmetic compositions, or other types of containers polyacrylamide, isoparaffin and laureth-7, multi-block Such as injection or blow-molded plastic containers into copolymers of acrylamides and Substituted acrylamides with which the dispersions or compositions or desired bottles, acrylic acids and Substituted acrylic acids. dispensers, or packages are retained. The kit and/or container can include indicia on its surface. The indicia, for example, 0082) Non-limiting examples of polysaccharides include can be a word, a phrase, an abbreviation, a picture, or a cellulose, carboxymethyl hydroxyethylcellulose, cellulose symbol. acetate propionate carboxylate, hydroxyethylcellulose, I0087. The containers can dispense a pre-determined hydroxyethyl ethylcellulose, hydroxypropylcellulose, amount of a composition. In other embodiments, the con hydroxypropyl methylcellulose, methyl hydroxyethylcellu tainer can be squeezed (e.g., metal, laminate, or plastic tube) lose, microcrystalline cellulose, Sodium cellulose Sulfate, and to dispense a desired amount of the composition. The com mixtures thereof. Another example is an alkyl substituted position can be dispensed as a spray, foam, an aerosol, a cellulose where the hydroxy groups of the cellulose polymer liquid, a fluid, or a semi-solid. The containers can have spray, is hydroxyalkylated (preferably hydroxyethylated or hydrox pump, or Squeeze mechanisms. A kit can also include instruc ypropylated) to form a hydroxyalkylated cellulose which is tions for using the kit and/or compositions. Instructions can then further modified with a Co-Co straight chain or include an explanation of how to apply, use, and maintain the branched chain alkyl group through an ether linkage. Typi compositions. cally these polymers are ethers of Co-Co straight or branched chain alcohols with hydroxyalkylcelluloses. Other EXAMPLES useful polysaccharides include Scleroglucans comprising a linear chain of (1-3) linked glucose units with a (1-6) linked I0088. The following examples are included to demon glucose every three unit. strate certain non-limiting aspects of the invention. It should be appreciated by those of skill in the art that the techniques 0083) Non-limiting examples of gums that can be used disclosed in the examples which follow represent techniques with the present invention include acacia, agar, algin, alginic discovered by the inventors to function well in the practice of acid, ammonium alginate, amylopectin, calcium alginate, the invention. However, those of skill in the art should, in light calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, of the present disclosure, appreciate that many changes can be gellan gum, guar gum, guar hydroxypropyltrimonium chlo made in the specific embodiments which are disclosed and ride, hectorite, hyaluroinic acid, hydrated silica, hydroxypro still obtain a like or similar result without departing from the pyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust spirit and scope of the invention. bean gum, natto gum, potassium alginate, potassium carrag eenan, propylene glycol alginate, Sclerotium gum, Sodium Example 1 carboyXmethyl dextran, Sodium carrageenan, tragacanth gum, Xanthan gum, and mixtures thereof. Compositions 0084 b. Pharmaceutical Ingredients I0089. The composition represented in Table 1 is a non 0085 Pharmaceutical ingredients are also contemplated limiting example of the types of compositions that can be as being useful with the emulsion compositions of the present used in the context of the present invention. Any standard invention. Non-limiting examples of pharmaceutical ingredi method can be used to prepare such a composition. For ents include anti-acne agents, agents used to treat rosacea, instance, simple mixing of the ingredients in a beaker can be analgesics, anesthetics, anorectals, antihistamines, anti-in used. One should mix Such ingredients and add heat as nec flammatory agents including non-steroidal anti-inflamma essary to obtain a homogenous composition. The Table 1 tory drugs, antibiotics, antifungals, antivirals, antimicrobials, composition is formulated into an emulsified cream. anti-cancer actives, Scabicides, pediculicides, antineoplas tics, antiperspirants, antipruritics, antipsoriatic agents, anti TABLE 3* Seborrheic agents, biologically active proteins and peptides, burn treatment agents, cauterizing agents, depigmenting Ingredient % Concentration (by weight) agents, depilatories, diaper rash treatment agents, enzymes, Water 62.3 Glycerin 5.3 hair growth stimulants, hair growth retardants including Octocrylene S.O DFMO and its salts and analogs, hemostatics, kerotolytics, Homosalate S.O canker Sore treatment agents, cold Sore treatment agents, Octisalate 4.5 dental and periodontal treatment agents, photosensitizing Distearyldimonium chloride 3.5 actives, skin protectant/barrier agents, steroids including hor Avobenzone 3.0 Butylene Glycol 3.0 mones and corticosteroids, Sunburn treatment agents, Sun Cetyl Alcohol 2.0 screens, transdermal actives, nasal actives, vaginal actives, Glyceryl Stearate 2.0 wart treatment agents, wound treatment agents, wound heal Butyrospermum parkii (shea) Butter 1.5 ing agents, etc. US 2013/0156711 A1 Jun. 20, 2013

TABLE 3-continued ballistometry is a small lightweight probe with a relatively blunt tip (4 Square mm-contact area) was used. The probe Ingredient % Concentration (by weight) penetrates slightly into the skin and results in measurements Niacinamide 1.O that are dependent upon the properties of the outer layers of Punica granatum sterols O.S the skin, including the stratum corneum and outer epidermis Chronoline O.S and some of the dermal layers. Tocopheryl acetate O.1 Euterpe oleracea Fruit Extract O.O1 0.095 Skin Softness/Suppleness Assay with a Gas Bearing Excipients ** C.S. Electrodynamometer: Skin softness/suppleness can be evalu ated using the Gas Bearing Electrodynamometer, an instru TOTAL 1OO ment that measures the stress/strain properties of the skin. The composition can be made by using simple mixing procedures. The ingredients can be The viscoelastic properties of skin correlate with skin mois added to a beaker and heated to 70-75°C, while mixing. Subsequently, the mixture can be cooled to room temperature with constant mixing. Mixing can be stopped once a homog turization. Measurements can be obtained on the predeter enous composition is obtained. mined site on the cheek area by attaching the probe to the skin **Chronoline is commercially available from Unipex Innovations (Canada). This product includes a combination of glycerinwateridextran?caprooyl-tetrapeptide-3, with the active surface with double-stick tape. A force of approximately 3.5 ingredient being caprooyl-tetrapeptide-3, ***Cosmetic or pharmaceutical excipients can be used to fill out the composition to create gm can be applied parallel to the skin Surface and the skin a desired product (e.g., cream, lotion, etc.), tactile property (e.g., non-oily feel, lightweight, displacement is accurately measured. Skin Suppleness can silky, etc.), viscosity (e.g., thicker or thinner formulation), and or a therapeutic effect (e.g., treatment offine lines and wrinkles, skin-whitening, evening skintone, increased collagen then be calculated and is expressed as DSR (Dynamic Spring production, etc.). Non-limiting examples of such excipients that can be used with the Table Rate in gm/mm). 1 formulation are known to those having skill in the cosmetic and pharmaceutical field including those disclosed in the present specification (e.g., moisturizing agents, antioxi 0096 Skin Moisture/Hydration Assay: Skin moisture/hy dants, structuring agents, essential and non-essential oils, thickening agents, preservatives, skin lightening agents, silicone containing compounds, vitamins, minerals, pharmaceutical dration benefits can be measured by using impedance mea ingredients, fragrances, colors, dyes, chelating agents, botanical extracts, anti-microbial surements with the Nova Dermal Phase Meter. The imped agents, anti-irritants, pH adjusters, exfoliants, etc.), ance meter measures changes in skin moisture content. The outer layer of the skin has distinct electrical properties. When Example 2 skin is dry it conducts electricity very poorly. As it becomes more hydrated increasing conductivity results. Consequently, Skin Moisturization Data changes in skin impedance (related to conductivity) can be 0090. The Table 1 composition was tested for its ability to used to assess changes in skin hydration. The unit can be moisturize human skin. Although data is not shown, the com calibrated according to instrument instructions for each test position moisturized human skin. ing day. A notation of temperature and relative humidity can also be made. Subjects can be evaluated as follows: prior to Example 3 measurement they can equilibrate in a room with defined humidity (e.g., 30-50%) and temperature (e.g., 68–72°C.). UV Data Three separate impedance readings can be taken on each side 0091. The Table 1 composition was tested for its ability to of the face, recorded, and averaged. The T5 setting can be absorb ultra violet radiation. Although data is not shown, the used on the impedance meter which averages the impedance composition exhibited ultra violet absorption characteristics values of every five seconds application to the face. Changes consisting with a rating of a Sun Protection Factor (SPF) of can be reported with statistical variance and significance. 15. 0097. Skin Dryness, Surface Lines, Skin Smoothness, and Skin Tone Assay: Skin dryness, Surface fine lines, skin Example 4 Smoothness, and skin tone can be evaluated with clinical grading techniques. For example, clinical grading of skin Stability Data dryness can be determined by a five point standard Kligman Scale: (0) skin is soft and moist; (1) skin appears normal with 0092. The Table 1 composition was confirmed to be stable no visible dryness; (2) skin feels slightly dry to the touch with under a heat stability test. The above formulation was tested no visible flaking; (3) skin feels dry, tough, and has a whitish for its stability using heat and was confirmed to have an appearance with some scaling; and (4) skin feels very dry, acceptable shelf-life (data not shown). rough, and has a whitish appearance with scaling. Evaluations can be made independently by two clinicians and averaged. Example 5 0.098 Skin Smoothness and Wrinkle Reduction Assay With Methods Disclosed in Packman et al. (1978): Skin Additional Assays that Can be Used to Test Smoothness and wrinkle reduction can also be assessed visu Compositions ally by using the methods disclosed in Packman and Gams 0093. The efficacy of the compositions of the present (1978). For example, at each subject visit, the depth, shallow invention can be determined by methods known to those of ness and the total number of superficial facial lines (SFLs) of ordinary skill in the art. The following are non-limiting assays each subject can be carefully scored and recorded. A numeri that can be used in the context of the present invention. It cal score was obtained by multiplying a number factor times should be recognized that other testing procedures can be a depth/width/length factor. Scores are obtained for the eye used, including, for example, objective and Subjective proce area and mouth area (left and right sides) and added together dures. as the total wrinkle score. 0094 Skin Firmness and Elasticity Assay with a Hargens 0099. Appearance of Lines and Wrinkles Assay with Rep Ballistometer: Skin firmness and elasticity can be measured licas: The appearance of lines and wrinkles on the skin can be using a Hargens ballistometer, a device that evaluates the evaluated using replicas, which is the impression of the skin's firmness and elasticity of the skin by dropping a small body surface. Silicone rubber like material can be used. The replica onto the skin and recording its first two rebound peaks. The can be analyzed by image analysis. Changes in the visibility US 2013/0156711 A1 Jun. 20, 2013 of lines and wrinkles can be objectively quantified via the or other details Supplementary to those set forth in this speci taking of silicon replicas form the Subjects face and analyZ fication, are specifically incorporated by reference. ing the replicas image using a computer image analysis sys 1. A topical skin care composition comprising: tem. Replicas can be taken from the eye area and the neck (a) 55 to 65% by weight of water; area, and photographed with a digital camera using a low (b) 15 to 20% by weight of a combination of 3,3,5-Trim angle incidence lighting. The digital images can be analyzed ethylcyclohexyl 2-hydroxybenzoate (homosalate), 1-(4- with an image processing program and are of the replicas Methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3-di covered by wrinkles or fine lines was determined. one (avobenzone), 2-ethylhexyl 2-hydroxybenzoate 0100 Surface Contour of the Skin Assay with a Profilo (octisalate), and 2-ethylhexyl 2-cyano-3,3-diphenyl-2- meter/Stylus Method: The surface contour of the skin can be propenoate (octocrylene); measured by using the profilometer/Stylus method. This (c) 3 to 4% by weight of distearlydimonium chloride; and includes either shining a light or dragging a stylus across the (d) 1 to 3% by weight of a combination of euterpe oleracea replica surface. The vertical displacement of the stylus can be fruit extract, punica granatum Sterols, caprooyltetrapep fed into a computer via a distance transducer, and after scan tide-3, tocopherol or tocopherol acetate, and niacina ning a fixed length of replica across-sectional analysis of skin mide, profile can be generated as a two-dimensional curve. This wherein the composition has a Sun protection factor of scan can be repeated any number of times along a fix axis to about 15 to 20. generate a simulated 3-D picture of the skin. Ten random 2. The topical skin care composition of claim 1, further sections of the replicas using the stylus technique can be comprising 5 to 10% by weight of a combination of glycerin obtained and combined to generate average values. The Val and butyrospermum parkii. ues of interest include Ra which is the arithmetic mean of all 3. The topical skin care composition of claim 2, compris roughness (height) values computed by integrating the profile 1ng: height relative to the mean profile height. Rt which is the 5% by weight of 3,3,5-Trimethylcyclohexyl 2-hydroxy maximum vertical distance between the highest peak and benzoate (homosalate); lowest trough, and RZ which is the mean peak amplitude 5% by weight of 2-ethylhexyl 2-cyano-3,3-diphenyl-2- minus the mean peak height. Values are given as a calibrated propenoate (octocrylene); value in mm. Equipment should be standardized prior to each 4.5% by weight of 2-ethylhexyl 2-hydroxybenzoate (octi use by scanning metal standards of know values. RaValue can Salate); and be computed by the following equation: R. Standardize 3% by weight of 1-(4-Methoxyphenyl)-3-(4-tert-butylphe roughness; 1, the traverse (scan) length; and y=the absolute nyl)propane-1,3-dione (avobenzone). value of the location of the profile relative to the mean profile 4. The topical skin care composition of claim 3, wherein height (X-axis). the composition does not include any additional UV absorb 0101 Skin Clarity and Reduction in Freckles and Age ing ingredients. Spots Assay: Skin clarity and the reduction infreckles and age 5. The topical skin care composition of claim 3, wherein spots can be evaluated using a Minolta Chromometer. the composition does not include para-aminobenzoic acid Changes in skin color can be assessed to determine irritation (PABA), PABA esters (glyceryl PABA, amyldimethyl PABA potential due to product treatment using the a values of the and octyldimethyl PABA), butyl PABA, ethyl PABA, ethyl Minolta Chroma Meter. The a value measures changes in dihydroxypropyl PABA, Sulisobenzone, cinnamates (and skin color in the red region. This is used to determine whether octyl methoxycinnamate, isoamyl p-methoxycinnamate, a composition is inducing irritation. The measurements can octylmethoxy cinnamate, cinoxate, diisopropyl methyl cin be made on each side of the face and averaged, as left and right namate, DEA-methoxycinnamate, ethyl diisopropylcin facial values. Skin clarity can also be measured using the namate, glyceryl octanoate dimethoxycinnamate and ethyl Minolta Meter. The measurement is a combination of the a, methoxycinnamate), cinnamate esters, salicylates (homom b, and L values of the Minolta Meter and is related to skin ethyl salicylate, benzyl salicylate, glycol salicylate, isopro brightness, and correlates well with skin Smoothness and pylbenzyl salicylate, etc.), anthranilates, ethylurocanate, Sty hydration. Skin reading is taken as above. In one non-limit renefacrylates copolymer, kaolin, talc, petrolatum and/or ing) aspect, skin clarity can be described as L/C where C is metal oxides (e.g., titanium dioxide and Zinc oxide). chroma and is defined as (a+b)4 6. The topical skin care composition of claim 5, further 0102 All of the skin-active ingredients, compositions, or comprising: methods disclosed and claimed in this specification can be butylene glycol; made and executed without undue experimentation in light of cetyl alcohol; and the present disclosure. While the skin-active ingredients, glyceryl Stearate. compositions, or methods of this invention have been 7. The topical skin care composition of claim 6, compris described in terms of particular embodiments, it will be 1ng: apparent to those of skill in the art that variations may be 2 to 4% by weight of butylene glycol; applied to the skin-active ingredients, compositions, or meth 1 to 3% by weight of cetyl alcohol; and ods and in the steps or in the sequence of steps of the method 1 to 3% by weight of glyceryl Stearate. described herein without departing from the concept, spirit 8. The topical skin care composition of claim 7, compris and scope of the invention. ing: REFERENCES 0.5 to 1.5% by weight of niacinamide: 0.1 to 1.0% by weight of punica granatum sterols; 0103) Any one of the references identified in the specifi 0.01 to 0.2% by weight oftocopheryl ortocopheryl acetate; cation, to the extent that they provide exemplary procedural and US 2013/0156711 A1 Jun. 20, 2013 12

0.001 to 0.02% by weight of euterpe oleracea fruit extract; and 0.00001 to 0.02% by weight of caprooyl tetrapeptide-3. 9. The topical skin care composition of claim 8, wherein the composition is an emulsion or a cream. 10. The topical skin care composition of claim 9, wherein the emulsion is an oil-in-water emulsion. 11. A method of treating skin comprising topically apply ing to skin in need thereof a composition of claim 1. 12. The method of claim 11, wherein the composition hydrates, increases firmness, reduces the appearance of fine lines or wrinkles, or reduces the appearance of age spots on said skin. 13. The method of claim 12, wherein the skin is hand skin and/or neck skin. 14. The method of claim 13, wherein the composition is applied to dry skin, saggy skin, a fine line or wrinkle, and/or an age spot.