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Clh Rep Methyl Salicylate En.Pdf CLH REPORT FOR [METHYL SALICYLATE] CLH report Proposal for Harmonised Classification and Labelling Based on Regulation (EC) No 1272/2008 (CLP Regulation), Annex VI, Part 2 International Chemical Identification: Methyl salicylate EC Number: 204-317-7 CAS Number: 119-36-8 Index Number: - Contact details for dossier submitter: ANSES (on behalf of the French MSCA) 14 rue Pierre Marie Curie F-94701 Maisons-Alfort Cedex [email protected] Version number: v1 Date: June 2018 CLH REPORT FOR [METHYL SALICYLATE] CONTENTS 1 IDENTITY OF THE SUBSTANCE ...................................................................................................................... 1 1.1 NAME AND OTHER IDENTIFIERS OF THE SUBSTANCE .............................................................................................. 1 1.2 COMPOSITION OF THE SUBSTANCE ........................................................................................................................ 2 2 PROPOSED HARMONISED CLASSIFICATION AND LABELLING ........................................................... 3 2.1 PROPOSED HARMONISED CLASSIFICATION AND LABELLING ACCORDING TO THE CLP CRITERIA ........................... 3 3 HISTORY OF THE PREVIOUS CLASSIFICATION AND LABELLING ..................................................... 5 4 JUSTIFICATION THAT ACTION IS NEEDED AT COMMUNITY LEVEL ................................................ 5 5 IDENTIFIED USES ............................................................................................................................................... 6 6 DATA SOURCES.................................................................................................................................................... 6 7 PHYSICOCHEMICAL PROPERTIES ................................................................................................................ 6 8 EVALUATION OF PHYSICAL HAZARDS ....................................................................................................... 8 8.1 EXPLOSIVES .......................................................................................................................................................... 8 8.2 FLAMMABLE GASES (INCLUDING CHEMICALLY UNSTABLE GASES) ........................................................................ 9 8.3 OXIDISING GASES .................................................................................................................................................. 9 8.4 GASES UNDER PRESSURE ....................................................................................................................................... 9 8.5 FLAMMABLE LIQUIDS ............................................................................................................................................ 9 8.6 FLAMMABLE SOLIDS ............................................................................................................................................. 9 8.7 SELF-REACTIVE SUBSTANCES ................................................................................................................................ 9 8.8 PYROPHORIC LIQUIDS ............................................................................................................................................ 9 8.9 PYROPHORIC SOLIDS ............................................................................................................................................. 9 8.10 SELF-HEATING SUBSTANCES ............................................................................................................................. 9 8.11 SUBSTANCES WHICH IN CONTACT WITH WATER EMIT FLAMMABLE GASES...................................................... 10 8.12 OXIDISING LIQUIDS......................................................................................................................................... 10 8.13 OXIDISING SOLIDS .......................................................................................................................................... 10 8.14 ORGANIC PEROXIDES ...................................................................................................................................... 10 8.15 CORROSIVE TO METALS .................................................................................................................................. 10 9 TOXICOKINETICS (ABSORPTION, METABOLISM, DISTRIBUTION AND ELIMINATION) ........... 10 9.1 SHORT SUMMARY AND OVERALL RELEVANCE OF THE PROVIDED TOXICOKINETIC INFORMATION ON THE PROPOSED CLASSIFICATION(S) ...................................................................................................................................... 12 10 EVALUATION OF HEALTH HAZARDS ......................................................................................................... 14 10.1 ACUTE TOXICITY ............................................................................................................................................ 14 10.1.1 Short summary and overall relevance of the provided information on acute oral toxicity .................. 16 10.1.2 Comparison with the CLP criteria ....................................................................................................... 16 10.1.3 Conclusion on classification and labelling for acute oral toxicity ....................................................... 16 10.2 SKIN SENSITISATION ....................................................................................................................................... 17 10.2.1 Short summary and overall relevance of the provided information on skin sensitisation .................... 23 10.2.2 Comparison with the CLP criteria ....................................................................................................... 27 10.2.3 Conclusion on classification and labelling for skin sensitisation ........................................................ 32 10.3 REPRODUCTIVE TOXICITY............................................................................................................................... 32 10.3.1 Adverse effects on sexual function and fertility .................................................................................... 32 10.3.2 Short summary and overall relevance of the provided information on adverse effects on sexual function and fertility ................................................................................................................................................ 34 10.3.3 Comparison with the CLP criteria ....................................................................................................... 39 10.3.4 Adverse effects on development ............................................................................................................ 39 CLH REPORT FOR [METHYL SALICYLATE] 10.3.5 Short summary and overall relevance of the provided information on adverse effects on development 42 10.3.6 Comparison with the CLP criteria ....................................................................................................... 52 10.3.7 Conclusion on classification and labelling for reproductive toxicity ................................................... 55 11 EVALUATION OF ENVIRONMENTAL HAZARDS ...................................................................................... 55 11.1 DEGRADATION ............................................................................................................................................... 55 1.1.1 Ready biodegradation (screening studies) ................................................................................................ 55 1.1.2 Abiotic degradation .................................................................................................................................. 57 11.1.1 Bioaccumulation .................................................................................................................................. 57 11.2 ACUTE TOXICITY ............................................................................................................................................ 57 11.2.1 Fish ...................................................................................................................................................... 57 11.2.2 Aquatic invertebrates ........................................................................................................................... 60 11.2.3 Algae and aquatic plants ...................................................................................................................... 62 11.3 CHRONIC TOXICITY ........................................................................................................................................ 65 11.4 COMPARISON WITH CLP CRITERIA ................................................................................................................. 65 11.4.1 Acute aquatic hazards .......................................................................................................................... 65 11.4.2 Chronic aquatic hazards ...................................................................................................................... 65 11.5 CONCLUSION ON CLASSIFICATION AND LABELLING FOR ENVIRONMENTAL HAZARDS ..................................... 66 12 EVALUATION OF ADDITIONAL HAZARDS ................................................................................................ 66 13 ADDITIONAL LABELLING
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