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Abstracts of Scientific Presentations 2011 AALAS National Meeting San Diego, California Journal of the American Association for Laboratory Animal Science Vol 50, No 5 Copyright 2011 September 2011 by the American Association for Laboratory Animal Science Pages 722–820 Abstracts of Scientific Presentations 2011 AALAS National Meeting San Diego, California Platform Sessions in managing personal and professional connections on one site, one should consider separating such connections, for example, keeping PS1 Evaluation of Different Bedding Substrates on the Reproductive personal connections on a social site, while maintaining business con- Success of 4 Mouse Strains nections through a professional site. Some social networking websites commonly incorporate applications where one is automatically enrolled DL Hickman*, MP Swan which share information with third parties such as what websites one may have visited. This presentation is designed for anyone that may Indiana University School of Medicine, Indianapolis, IN be considering the use, or is already using social networking media. It will provide some “dos and don’ts,” as well as educate the participant Bedding substrate selection can be a difficult decision for the advi- on successful navigation through the social media cyber world. sory staff as picking a universal bedding is highly dependent on cost, researcher need, and facility preference. This study examined the effects PS3 Post Approval Monitoring: Lessons Learned of bedding substrate on reproductive success to evaluate concerns that * phytoestrogens or mitogens in corncob based beddings may interfere S Doss , R Banks with reproductive success in mice. Thirty-six each of ICR, C57BL/6, C3H, and DBA mice were placed into monogamous breeding pairs and Office of Animal Welfare Assurance, Duke University Medical Center, divided into 3 treatment groups with an n = 6 per group. Each group Durham, NC was placed on one of 3 substrates: ¼’ corncob bedding, shredded aspen, or recycled paper. The pairs were maintained continuously for 4 mo or Institutional Animal Care and Use Committees (IACUC) are charged, until the third litter of offspring was weaned. Pups per female per day, under federal laws, regulations, and policies, with providing oversight a commonly used calculation to monitor the production efficiency of of all animal activities. In smaller animal care programs, oversight may commercial mouse colonies, was compared between bedding substrate be accomplished by IACUC members and veterinary staff; however, using an ANOVA. No statistical significance was found between bed- as the size and complexity of the animal care program increases the ding substrate treatment groups (ICR, P = 0.4679; C57BL/6, P = 0.3912; oversight burden also increases. One means of accomplishing this C3H, P = 0.6510; DBA, P = 0.9545). No statistical significance was found oversight is by creating and implementing a program of post approval in the success survivability for each litter, as defined by number of pups monitoring. Endorsed in the eighth edition of the Guide for the Care and weaned divided by number of pups born, between bedding substrate Use of Laboratory Animals, the concept of post approval monitoring after treatment groups when analyzed by ANOVA (ICR, P = 0.5999; C57BL/6, the initial IACUC protocol approval provides a valuable tool to the P = 0.9962; C3H, P = 0.5574; DBA, P = 0.4307). No statistical significance institution to assure the integrity of the program. Your institution may was found in the number of litters produced by each female between consider planning and applying a program of post approval monitor- bedding substrate treatment groups (ICR, P = 0.4490; C57BL/6, P = ing, just as our institution did in the fall of 2004. Over the last 7 y, our 0.2948; C3H, P = 0.3482; DBA, P = 0.9229) when analyzed by ANOVA. post approval monitoring program has adapted to meet the needs of This study demonstrated that there were no statistically significant our research community. The post approval monitoring program that differences in the reproductive efficiency of these 2 strains of mice initially revealed a relatively low compliance rate and encountered when housed on these 3 bedding types, suggesting that all are suitable resistance from investigators has evolved into a program that exhibits a possibilities for the support of mouse breeding colonies. high percentage of compliance, acceptance by the research community, and self-reporting of potential noncompliance and adverse events from PS2 Social Media and Laboratory Animal Science: Dos and Don’ts research staff. Several supplemental programs have been designed and for Laboratory Animal Science Personnel implemented as a result of the post approval monitoring program: required yearly online training for all animal users which emphasizes SW Baran*1,2, MI Perret-Gentil3, J Kehler1 the main compliance issues from the previous year, an institutional research animal coordinator program, and numerous IACUC policies 1Veterinary Bioscience Institute, Harleysville, PA; 2Office of Professional including adverse events and controlled substances. The program of Studies in the Health Sciences, Drexel University College of Medicine, post approval monitoring has provided our institution with the best in- Philadelphia, PA; 3Laboratory Animal Resources Center, The University surance of animal wellbeing and welfare and quality research outcomes. of Texas at San Antonio, San Antonio, TX PS4 Use of Review Software for IACUC Protocol Review and Member Social media is rapidly gaining enormous momentum, and today 47% Training Documentation of online adults use a social networking website. Social media is chang- * ing the way we communicate both in our personal and professional lives. J Lyons , SL Pritt Utilization of these sites provides great opportunities for networking but not without the risk of losing privacy. We will address social media, Absorption Systems, San Diego, CA the effect it may have on management and employees, the security of the employee’s company, and suggested guidelines for individuals of Many Institutional Animal Care and Use Committee (IACUC) proto- the laboratory animal community to consider before posting personal col management software systems exist. The majority of these systems information on social networking sites. Another very important factor is require customization, significant lead time, and changes to existing the potential exposure of people in the LAS community to animal rights protocol templates. Some have minimal to no ability to document activists. Social media can expand the interaction between you and your IACUC member training. Our facility sought a readily available, cost employees beyond the work place, but it can also contribute to daily effective, web-based system that focused only on document review. distractions. Managers should consider categorizing their connections A review software was selected as a hosted, web-based document into professional and personal connections. Professional connections review system that tracks changes, comments, and responses made provide an opportunity to ask and receive valuable input to questions, from multiple reviewers and authors. We chose to retain our IACUC share opportunities, and discuss work related challenges. For managers protocol form in a word-processing document template. New IACUC wishing to network (whether it be through electronic media or other protocols are uploaded into the review software for prereview by the means) with their staff, an issue to consider might be the perception of attending veterinarian, since the program allows document review by preferential treatment towards a particular employee. Perceived ineq- different, sequential layers of reviewers. During reviews, members can uities could result in resentment and loss of unit morale. People that insert comments and questions into the document. Once the attending connect with business associates on social networking sites should be veterinarian’s review is complete, the document is opened up for review cautious on how their postings are perceived. Because of the difficulty by all IACUC members. Emails are automatically generated and sent to 722 Abstracts of scientific papers 2011 AALAS National Meeting IACUC members when a protocol is ready for review. All members can in vivo can be disrupted by light at night via melatonin suppression, state if the protocol is acceptable for designated member review (DMR) predisposing animals to type II diabetes. Improved facility design and or must go to full committee. Selected protocols are approved by the adherence to diurnal lighting protocols, as outlined in The Guide, are DMR, plus time stamped and dated. Standard operating procedures, essential to the health and wellbeing of laboratory animals and to the regulatory documents, and other training items can be uploaded. IA- credible outcome of scientific investigations. CUC members receive automated emails inviting them to review the items and document their training. Each user is given a username and PS7 When Undergraduates are Targets: Considering Animal Rights password and has access to the review software training modules. It Extremists and Student Safety in the IACUC Crisis Management Plan took approximately 1 mo to convert to the review software system. The existing protocol numbering system was retained. The review software JD Stemwedel* offers a convenient, secure, web-based approach to reviewing and approving IACUC documents without the need to purchase software Philosophy, San Jose State University, San Jose, CA systems that
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