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Rosemary)-Derived Ingredients As Used in Cosmetics

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Rosemary)-Derived Ingredients As Used in Cosmetics Safety Assessment of Rosmarinus Officinalis (Rosemary)-Derived Ingredients as Used in Cosmetics Status: Tentative Amended Report for Public Comment Release Date: March 28, 2014 Panel Meeting Date: June 9-10, 2014 All interested persons are provided 60 days from the above release date to comment on this safety assessment and to identify additional published data that should be included or provide unpublished data which can be made public and included. Information may be submitted without identifying the source or the trade name of the cosmetic product containing the ingredient. All unpublished data submitted to CIR will be discussed in open meetings, will be available at the CIR office for review by any interested party and may be cited in a peer-reviewed scientific journal. Please submit data, comments, or requests to the CIR Director, Dr. Lillian J. Gill. The 2014 Cosmetic Ingredient Review Expert Panel members are: Chairman, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Ronald A. Hill, Ph.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Director is Lillian J. Gill, D.P.A. This safety assessment was prepared by Monice M. Fiume, Assistant Director/Senior Scientific Analyst. © Cosmetic Ingredient Review 1620 L Street, NW, Suite 1200♢ Washington, DC 20036 ♢ ph 202.331.0651 ♢ fax 202.331.0088 ♢ [email protected] TABLE OF CONTENTS Abstract ....................................................................................................................................................................................................................................... 1 Introduction ................................................................................................................................................................................................................................. 1 Chemistry .................................................................................................................................................................................................................................... 1 Definition ............................................................................................................................................................................................................................... 1 General Characterization ....................................................................................................................................................................................................... 1 Chemical and Physical Properties .......................................................................................................................................................................................... 1 Preparation/Extraction ........................................................................................................................................................................................................... 1 Constituents/Impurities .......................................................................................................................................................................................................... 2 Use .............................................................................................................................................................................................................................................. 3 Cosmetic ................................................................................................................................................................................................................................ 3 Non-Cosmetic ........................................................................................................................................................................................................................ 3 Toxicokinetics ............................................................................................................................................................................................................................. 4 Penetration Enhancement ....................................................................................................................................................................................................... 4 Toxicological Studies .................................................................................................................................................................................................................. 4 Single Dose (Acute) Toxicity ................................................................................................................................................................................................ 4 Repeated Dose Toxicity ......................................................................................................................................................................................................... 4 Ocular Irritation ..................................................................................................................................................................................................................... 4 Anti-Inflammatory Effects ..................................................................................................................................................................................................... 4 Effect on Epidermal Hyperplasia ........................................................................................................................................................................................... 4 Immunologic Effects.............................................................................................................................................................................................................. 5 Reproductive and Developmental Toxicity ................................................................................................................................................................................. 5 Non-Human...................................................................................................................................................................................................................... 5 Human .............................................................................................................................................................................................................................. 5 Effects on Estrogenic Activity ............................................................................................................................................................................................... 5 Non-Human...................................................................................................................................................................................................................... 5 Human .............................................................................................................................................................................................................................. 5 Genotoxicity ................................................................................................................................................................................................................................ 6 Carcinogenicity ........................................................................................................................................................................................................................... 6 Effects on Tumor Promotion .................................................................................................................................................................................................. 6 Irritation and Sensitization .......................................................................................................................................................................................................... 6 Skin Irritation/Sensitization ................................................................................................................................................................................................... 6 Phototoxicity .......................................................................................................................................................................................................................... 6 Case Reports .......................................................................................................................................................................................................................... 7 Summary ..................................................................................................................................................................................................................................... 7 Discussion ..................................................................................................................................................................................................................................
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