Partial Purification and Properties of S-Adenosylmethionine. (R), (S

Total Page:16

File Type:pdf, Size:1020Kb

Partial Purification and Properties of S-Adenosylmethionine. (R), (S Planta Journal of Medicinal Plant Research medica Organ der Editor-in-Chief A. Baerheim-Svendsen, E. Hecker, Heidelberg J. M. Rowson, Mablethorpe Gesellschaft für E. Reinhard, Tübingen Leiden R. Hegnauer, Leiden M. v. Schantz, Helsinki Arzneipflanzen• Pharmazeutisches Institut H. Böhm, Halle W. Herz, Tallahassee K. F. Sewing, Hannover forschung Auf der Morgenstelle 8 F. Bohlmann, Berlin K. Hostettmann, Lausanne E. J. Shellard, London D-7400 Tübingen A. Cave, Chatenay-Malabry H. Inouye, Kyoto S. Shibata, Tokyo P. Delaveau, Paris M. A. Iyengar, Manipal Ch. Tamm, Basel Editorial Board Ding Guang-sheng, F. Kaiser, Mannheim W. S. Woo, Seoul H. P. T. Ammon, Tübingen Shanghai F. H. Kemper, Münster Xiao Pei-gen, Beijing W. Barz, Münster C. -J. Estler, Erlangen W. R. Kukovetz, Graz E. Reinhard, Tübingen N. Farnsworth, Chicago J. Lemli, Leuven •O. Sticher, Zürich H. Floss, Columbus Liang Xiao-tian, Beijing H. Wagner, München H. Friedrich, Münster M. Lounasmaa, Helsinki M. H. Zenk, München D. Fritz, Weihenstephan M. Luckner, Halle A. G. Gonzalez, La Laguna J. Lutomski, Poznan Advisory Board O. R. Gottlieb, Sao Paulo H. Menßen, Köln N. Anand, Lucknow E. Graf, Köln E. Noack, Düsseldorf R. Anton, Strasbourg H. Haas, Mannheim J. D. Phillipson, London Contents Volume 49,1983 ISSN 0032-0943 (f) Hippokrates Hippokrates Verlag Stuttgart II Contents 49,1983 Atta-ur-Rahman, Bashir, M.\ Isolation of New Alkaloids Cannabinoids in Phelipaea ramosa, a Parasite of Canna• from Catharanthus roseus 124 bis sativa) 250 Atta-ur-Rahman, Nisa, M., Farhi, S.: Isolation of Moenjod- aramine from Buxus papilosa 126 Galun, £., Aviv, D., Dantes, A., Freeman, A. \ Biotransfor• mation by Plant Cells Immobilized in Cross-Linked Poly- Balsevich, J., Kurz, W. G. W.: The Role of 9- and/or 10- acrylamide-Hydrazide. Monoterpene Reduction by En- oxygenated Derivatives of Geraniol, Geranial, Nerol, trapped Mentha Cells 9 and Neral in the Biosynthesis of Loganin and Ajmalicine 79 Ghosal, Sh., Singh, A.K., Biswas, K.: New6-Aryl-2-pyrones Bassleer, R., Marnette, J.-M., Wiliquet, Ph., De Pauw-Gillet, from Gentiana pedicellata 240 M.-CL, Caprasse, M., Angenot, L. \ Etüde complemen- taire de la cytotoxicite de la melinonine F, alcaloide derive Hafez, A., Adolf, W., Hecker, E.\ Active Principles of the de la ß-carboline (Complementary Study of Cytotoxic Thymelaeaceae. III. Skin Irritant and Cocarcinogenic Activity of Melinonine F) 158 Factors from Pimelea simplex 3 Becker, H., Chavadej, S., Weberling, F.: Valepotriates in Valeriana thalictroides 64 Ieven, M., van den Berghe, D. A., Vlietinck, A. J.\ Plant Becker, H., Herold, S.: RP-8 als Hilfsphase zur Akkumula• Antiviral Agents. IV. Influence of Lycorine on Growth tion von Valepotriaten aus Zellsuspensionskulturen von Pattern of Three Animal Viruses 109 Valeriana wallichii (RP-8 Auxiliary Phase for the Accu- Ishiguro, K., Yamaki, M.y Takagi, S.: Studies on Iridoid- mulation of Valepotriates from Cell-Suspension-Culture related Compounds; III: Gentiopicral, the Aglucone of of Valeriana wallichii) 191 Gentiopicroside 208 Bounthanh, C, Richert, L., Beck, J. P., Haag-Berrurier, M., Anton, R.: The Action of Valepotriates on the Synthesis Jakovlev, V., Isaac, O., Flaskamp, E.: Pharmakologische of DNA and Proteins of Cultured Hepatoma Cells. ... 138 Untersuchungen von Kamillen-Inhaltsstoffen, VI. Unter• Briangon-Scheid, F., Lobstein-Guth, A., Anton, R.: HPLC suchungen zur antiphlogistischen Wirkung von Chama- Separation and Quantitative Determination of Biflavones zulen und Matricin (Pharmacological Investigations with in Leaves from Ginkgo biloba 204 Compounds of Chamomile, VI. Investigations on the Antiphlogistic Effects of Chamazulene and Matricine) 67 Caputo, O., Delprino, L., Viola, F., Caramiello, R.f Bal- Joshi, K. C, Singh, P., Taneja, S.: A Sesquiterpenoid Naph- liano, G.: Biosynthesis of Sterols and Triterpenoids in thol from Kydia calycina 127 Tissue Cultures of Cucurbita maxima 176 Jossang, A., Lebceuf, M., Cabalion, P., Cave, A.: Alcaloides Chagnon, M., Ndibwami, A., Dube, S., Bumaya, A.: Ac- des Annonacees. XLV: Alcaloides de Polyalthia niti- tivite Anti-Inflammatoire d'Extraits de Crassocephalum dissima (Alkaloids from Annonaceae. XLV: Alkaloids multicorymbosum (Anti-inflammatory Action of an Ex- of Polyalthia nitidissima) 20 tract from Crassocephalum multicorymbosum) 255 Chattopadhyay, S., Chattopadhyay, U., Mathur, P. P., Saini, Kimura, Y., Ohminami, H., Okuda, H., Baba, K., Kozawa, K. S., Ghosal, S.: Effects of Hippadine, an Amarylli- M., Arichi, S.: Effects of Stilbene Components of Roots daceae Alkaloid, on Testicular Function in Rats 252 of Polygonum ssp. on Liver Injury in Peroxidized Oil-fed Chen Weiming, Yan Yaping, LiangXiaotian: Alkaloids from Rats 51 Roots of Alstonia yunnanensis 62 Kisiel, W.: 8-Epidesacylcynaropicrin from Crepis capillaris 246 Kiso, Y., Suzuki, Y., Watanabe, N., Oshima, Y., Hikino, H.: Dehaussy, H., Tits, M., Angenot, L.\ La guattegaumerine, Antihepatotoxic Principles of Curcuma longa Rhizomes 185 nouvel alcaloide bisbenzylisoquinoleinique de Guatteria Kiso, Y., Tohkin, M., Hikino, H.: Assay Method for Anti• gaumeri (Guattegaumerine, New Bisbenzylisoquinoline hepatotoxic Activity Using Carbon Tetrachloride In- Alkaloid from Guatteria gaumeri) 25 duced Cytotoxicity in Primary Cultured Hepatocytes . 222 Dominguez, X. A., Franco, R., Cano, G., Ma. Consue lo Kram, G., Franz, G.\ Untersuchungen über die Schleim- Garcia, F., Xorge A. Dominguez, S. Jr., Leonardo de la polysaccharide aus Lindenblüten (Analysis of Linden Pena9M.: Isolation of a New Furano-l,4-Naphthaquinone, Flower Mucilage) 149 Diodantunezone from Lanthana achyranthifolia .... 63 Krüger, D., Junior, P., Wichtl, M.\ Neue Cardenolidglyko- side aus Digitalis lanata (New Cardiac Glycosides from Endo, K., Oshima, Y.t Kikuchi, H., Koshihara, Y., Hikino, Digitalis lanata) 74 H.: Hypotensive Principles of Uncaria Hooks 188 Engelshowe, R.: Dimere Proanthocyanidine als Gerbstoff• Langhammer, L., Schulze, G., Gujer, R., Magnolato, D., vorstufen in Juniperus communis (Tannin Producing Horisberger, M.\ Isolation and Structure of a Rarely Dimeric Proanthocyanidins in Juniperus communis). 170 Occurring Cyanidanol Glycoside from Cortex Betulae . 181 Esterl, A., Gab, S., Bieniek, D.\ Zur Kenntnis der Inhalts• Lemli, J., Cuveele, J., Verhaeren, E.\ Chemical Identification stoffe von Isertia hypoleuca (On The Constituents of of Alexandrian and Tinnevelly Senna. Studies in the Isertia hypoleuca) 244 Field of Drugs Containing Anthracene Derivatives XXXIV 36 Fournier, G., Paris, M.: Mise en Evidence de Cannabinoi'des Long-Ze Lin, Wagner, H., Seligmann, ö.\ Thalifaberine, Chez Phelipaea ramosa, Orobanchacees, Parasitant le Thalifabine and Huangshanine, Three New Dimeric Chanvre, Cannabis sativa, Cannabinacees (Detection of Aporphine-Benzylisoquinoline Alkaloids 55 Contents III Man-Po Wong, Teh-Chang Chiang, Hson-Mou Chang: Chem• Rueffer, M., Nagakura, N., Zenk, M. H.: Partial Purification ical Studies on Dangshen, the Root of Codonopsis pilo- and Properties of S-Adenosylmethionine: (R), (S)-Nor- sula 60 laudanosoline-6-O-Methyltransferase from Argemone Misawa, M., Hayashi, M., Takayama, S.: Production of platyceras Cell Cultures 131 Antineoplastic Agents by Plant Tissue Cultures. I. In- duction of Callus Tissues and Detection of the Agents in Sariyar, G.: Alkaloids from Papaver triniifolium of Turkish Cultured Cells 115 Origin 43 Seip, E. H., Ott, H. H., Hecker, £.: Skin Irritant and Tumor Nahrstedt, A., Wray, V., Grotjahn, L., Fikenscher, L. H., Promoting Diterpene Esters of the Tigliane Type from Hegnauer, R.: New Acylated Cyanogenic Diglycosides the Chinese Tallow Tree (Sapium sebiferum) 199 from Fruits of Anthemis cairica 143 Sepulveda-Boza, S., Friedrichs, £., Puff, H., Breitmaier, £.: Nomura, T, Fukai, T.} Shimada, T, Ih-Sheng Chen: Com- Ein iso-Homoprotoberberin-Alkaloid aus den Wurzeln ponents of Root Bark of Morus australis. I. Structure of von Berberis actinacantha (An iso-Homoprotoberberin- a New 2-Arylbenzofuran Derivative, Mulberrofuran D. 90 Alkaloid from the Roots of Berberis actinacantha). ... 32 Shoyama, Y., Hatano, K., Nishioka, /.: Clonal Multiplica- Obata-Sasamoto, H., Komamine, A.: Effect of Culture Con- tion of Pinellia ternata by Tissue Culture 14 ditions on DOPA Accumulation in a Callus Culture of Stoianova-lvanova, B., Budzikiewicz, H., Koumanova, B., Stizolobium hassjoo 120 Tsoutsoulova, A., Mladenova, K., Brauner, A.: Essential Ohiri, F. C, Verpoorte, R., Baerheim Svendsen, Ar. !H NMR Oil of Chrysanthemum indicum 236 Chemical Shift Values for Aromatic Protons in 2,3,9,10- and 2,3,10,11-tetrasubstituted Tetrahydroprotoberberine Teh-Chang Chiang, Hson-Mou Chang, Mak, Th. C. W.: New Alkaloids 162 Oleanene-type Triterpenes from Abrus precatorius and Ohiri, F. C, Verpoorte, R., Baerheim Svendsen, A:Tertiary X-ray Crystal Structure of Abrusgenic Acid-Methanol Phenolic Alkaloids from Chasmanthera dependens ... 17 1:1 Solvate 165 Ojewole, J. A. O., Adesina, S. K.: Mechanism of the Hypo- tensive Effect of Scopoletin Isolated from the Fruit of Tetrapleura tetraptera 46 van derSluis, W. G., van der Nat, J. M., Spek, A. L., Ike- shiro, Y., Labadie, R. P.: Gentiogenal, aConversion Pro- Ojewole, J. A. O., Adesina, S. K. \ Cardiovascular and Neuro- duct of Gentiopicrin (Gentiopicroside) 211 muscular Actions of Scopoletin from Fruit of Tetrapleura tetraptera 99 Okogun, J. /., Adeboye, J. O., Okorie, D. A.\ Novel Struc- Wagner, H., Schwarting, G., Varljen, J., Bauer, R., Ham- tures of two Chromone Alkaloids from Root-Bark of dard, M. £.,
Recommended publications
  • “Biosynthesis of Morphine in Mammals”
    “Biosynthesis of Morphine in Mammals” D i s s e r t a t i o n zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) vorgelegt der Naturwissenschaftlichen Fakultät I Biowissenschaften der Martin-Luther-Universität Halle-Wittenberg von Frau Nadja Grobe geb. am 21.08.1981 in Querfurt Gutachter /in 1. 2. 3. Halle (Saale), Table of Contents I INTRODUCTION ........................................................................................................1 II MATERIAL & METHODS ........................................................................................ 10 1 Animal Tissue ....................................................................................................... 10 2 Chemicals and Enzymes ....................................................................................... 10 3 Bacteria and Vectors ............................................................................................ 10 4 Instruments ........................................................................................................... 11 5 Synthesis ................................................................................................................ 12 5.1 Preparation of DOPAL from Epinephrine (according to DUNCAN 1975) ................. 12 5.2 Synthesis of (R)-Norlaudanosoline*HBr ................................................................. 12 5.3 Synthesis of [7D]-Salutaridinol and [7D]-epi-Salutaridinol ..................................... 13 6 Application Experiments .....................................................................................
    [Show full text]
  • M.Sc. CHEMISTRY
    M.Sc. CHEMISTRY ANALYTICAL CHEMISTRY SPECIALISATION SYLLABUS OF III & IV SEMESTERS REVISED AS PER NEW (CB) SYLLABUS FOR STUDENTS ADMITTED FROM THE YEAR 2016 ONWARDS M.Sc. CHEMISTRY (ANALYTICAL CHEMISTRY SPECIALISATION) Syllabus for III and IV Semesters (for the batches admitted in academic year 2016 & later under CBCS pattern) [Under Restructured CBCS Scheme] Grand total marks and credits (all 4 semesters) 2400 marks – 96 credits (Approved in the P.G. BOS meeting held on 01-07-2017) Semester - III (ANALYTICAL CHEMISTRY) [Under CBCS Scheme] (for the batches admitted in academic year 2016 & later under CBCS pattern) Hrs/week Internal assessment Semester exam Total Credits CH(AC)301T (core) 4 20 marks 80 marks 100 marks 4 CH(AC)302T (core) 4 20 marks 80 marks 100 marks 4 CH(AC)303T (Elective) 4 20 marks 80 marks 100 marks 4 CH(AC)304T (Elective) 4 20 marks 80 marks 100 marks 4 CH(AC)351P (LAB-I) 9 100 marks 4 CH(AC)352P (LAB-II) 9 100 marks 4 Total 600 marks 24 Semester - IV (ANALYTICAL CHEMISTRY) Hrs/week Internal assessment Semester exam Total Credits CH(AC)401T (core) 4 20 marks 80 marks 100 marks 4 CH(AC)402T (core) 4 20 marks 80 marks 100 marks 4 CH(AC)403T (Elective) 4 20 marks 80 marks 100 marks 4 CH(AC)404T (Elective) 4 20 marks 80 marks 100 marks 4 CH(AC)451P (LAB-I) 9 100 marks 4 CH(AC)452P (LAB-II) 9 100 marks 4 Total 600 marks 24 Grand total marks and credits (all 4 semesters) 2400 marks - 96 credits M.Sc.ANALYTICAL CHEMISTRY Semester III Paper I :CH (AC) 301T: CORE : Sampling, Data handling, Classical and Atomic spectral methods
    [Show full text]
  • 1. Introduction
    Introduction 1. Introduction 1.1. Alkaloids The term alkaloid is derived from Arabic word al-qali, the plant from which “soda” was first obtained (Kutchan, 1995). Alkaloids are a group of naturally occurring low-molecular weight nitrogenous compounds found in about 20% of plant species. The majority of alkaloids in plants are derived from the amino acids tyrosine, tryptophan and phenylalanine. They are often basic and contain nitrogen in a heterocyclic ring. The classification of alkaloids is based on their carbon-nitrogen skeletons; common alkaloid ring structures include the pyridines, pyrroles, indoles, pyrrolidines, isoquinolines and piperidines (Petterson et al., 1991; Bennett et al., 1994). In nature, plant alkaloids are mainly involved in plant defense against herbivores and pathogens. Many of these compounds have biological activity which makes them suitable for use as stimulants (nicotine, caffeine), pharmaceuticals (vinblastine), narcotics (cocaine, morphine) and poisons (tubocurarine). The discovery of morphine by the German pharmacist Friedrich W. Sertürner in 1806 began the field of plant alkaloid biochemistry. However, the structure of morphine was not determined until 1952 due to its stereochemical complexity. Major technical advances occurred in this field allowing for the elucidation of selected alkaloid biosynthetic pathways. Among these were the introduction of radiolabeled precursors in the 1950s and the establishment in the 1970s of plant cell suspension cultures as an abundant source of enzymes that could be isolated, purified and characterized. Finally, the introduction of molecular techniques has made possible the isolation of genes involved in alkaloid secondary pathways (Croteau et al., 2000; Facchini, 2001). 1.1.1. Benzylisoquinoline alkaloids Isoquinoline alkaloids represent a large and varied group of physiologically active natural products.
    [Show full text]
  • Chapter Two Biomimetic Partial Synthesis Of
    CHAPTER TWO BIOMIMETIC PARTIAL SYNTHESIS OF VALPARICINE AND APPARICINE 2.1 Introduction 2.1.1 Alkaloids of Kopsia arborea A total of 62 alkaloids were isolated from the stem-bark and leaves of Kopsia arborea of which 25 are new alkaloids. Among the alkaloids isolated are valparicine (28),26,27 pericine (31),26,28,29 pericidine (32),30,31 arbophylline (33),32 arboricine (34),30,33 arboricinine (35),30,33 arboflorine (36),30,34 arboloscine (37),30,31 and mersicarpine (38).35 14 The compounds of interest to this research are valparicine (28) and pericine (31). Valparicine (28) was isolated from the stem-bark extract of K. arborea in trace amount. It represents the first member of the pericine-type alkaloids, characterized by a 16-22 exocyclic double bond, in which bond-formation has occurred between C-3 and C-7.26 Preliminary tests indicated that valparicine (28) showed strong cytotoxic effects −1 against human KB cells (IC50 < 5 μgmL ). Valparicine (28) was obtained as a colorless oil, with [α]D −40 (c 0.22, CHCl3). The UV spectrum (228 and 297 nm) indicated the presence of an unsubstituted indolenine chromophore. The EIMS of 28 showed a molecular ion at m/z 276, which 13 analyzed for C19H20N2, differing from pericine (31) by loss of two hydrogens. The C NMR spectrum gave a total of 19 carbon resonances (one methyl, five methylenes, seven methines, and six quaternary carbons) in agreement with the molecular formula. In addition to the six carbon resonances readily attributable to the aromatic moiety, and the imine resonance at δC 186.4, two other downfield quaternary resonances were observed at δC 139.2 and 144.6.
    [Show full text]
  • Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae
    Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae Daniel, Bastian; Wallner, Silvia; Steiner, Barbara; Oberdorfer, Gustav; Kumar, Prashant; van der Graaff, Eric; Roitsch, Thomas; Sensen, Christoph W; Gruber, Karl; Macheroux, Peter Published in: PLOS ONE DOI: 10.1371/journal.pone.0156892 Publication date: 2016 Document version Publisher's PDF, also known as Version of record Citation for published version (APA): Daniel, B., Wallner, S., Steiner, B., Oberdorfer, G., Kumar, P., van der Graaff, E., ... Macheroux, P. (2016). Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae. PLOS ONE, 11(6), e0156892. https://doi.org/10.1371/journal.pone.0156892 Download date: 08. Apr. 2020 RESEARCH ARTICLE Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae Bastian Daniel1, Silvia Wallner1, Barbara Steiner1, Gustav Oberdorfer2, Prashant Kumar2, Eric van der Graaff3, Thomas Roitsch3,4, Christoph W. Sensen5, Karl Gruber2, Peter Macheroux1* 1 Institute of Biochemistry, Graz University of Technology, Graz, Austria, 2 Institute of Molecular Biosciences, University of Graz, Graz, Austria, 3 Department of Plant and Environmental Sciences, a11111 University of Copenhagen, Copenhagen, Denmark, 4 Global Change Research Centre, Czech Globe AS CR, v.v.i., Drásov 470, Cz-664 24 Drásov, Czech Republic, 5 Institute of Molecular Biotechnology, Graz University of Technology, Graz, Austria * [email protected] OPEN ACCESS Abstract Citation: Daniel B, Wallner S, Steiner B, Oberdorfer Berberine bridge enzyme-like (BBE-like) proteins form a multigene family (pfam 08031), G, Kumar P, van der Graaff E, et al.
    [Show full text]
  • Dr. Duke's Phytochemical and Ethnobotanical Databases Chemicals Found in Papaver Somniferum
    Dr. Duke's Phytochemical and Ethnobotanical Databases Chemicals found in Papaver somniferum Activities Count Chemical Plant Part Low PPM High PPM StdDev Refernce Citation 0 (+)-LAUDANIDINE Fruit -- 0 (+)-RETICULINE Fruit -- 0 (+)-RETICULINE Latex Exudate -- 0 (-)-ALPHA-NARCOTINE Inflorescence -- 0 (-)-NARCOTOLINE Inflorescence -- 0 (-)-SCOULERINE Latex Exudate -- 0 (-)-SCOULERINE Plant -- 0 10-HYDROXYCODEINE Latex Exudate -- 0 10-NONACOSANOL Latex Exudate Chemical Constituents of Oriental Herbs (3 diff. books) 0 13-OXOCRYPTOPINE Plant -- 0 16-HYDROXYTHEBAINE Plant -- 0 20-HYDROXY- Fruit 36.0 -- TRICOSANYLCYCLOHEXA NE 0 4-HYDROXY-BENZOIC- Pericarp -- ACID 0 4-METHYL-NONACOSANE Fruit 3.2 -- 0 5'-O- Plant -- DEMETHYLNARCOTINE 0 5-HYDROXY-3,7- Latex Exudate -- DIMETHOXYPHENANTHRE NE 0 6- Plant -- ACTEONLYDIHYDROSANG UINARINE 0 6-METHYL-CODEINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 0 6-METHYL-CODEINE Fruit -- 0 ACONITASE Latex Exudate -- 32 AESCULETIN Pericarp -- 3 ALANINE Seed 11780.0 12637.0 0.5273634907250652 -- Activities Count Chemical Plant Part Low PPM High PPM StdDev Refernce Citation 0 ALKALOIDS Latex Exudate 50000.0 250000.0 ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes. 5 ALLOCRYPTOPINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 15 ALPHA-LINOLENIC-ACID Seed 1400.0 5564.0 -0.22115561650586155 -- 2 ALPHA-NARCOTINE Plant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. 17 APOMORPHINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 0 APOREINE Fruit -- 0 ARABINOSE Fruit ANON.
    [Show full text]
  • Redalyc.Identification of Isoquinoline Alkaloids from Berberis Microphylla
    Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas ISSN: 0717-7917 [email protected] Universidad de Santiago de Chile Chile MANOSALVA, Loreto; MUTIS, Ana; DÍAZ, Juan; URZÚA, Alejandro; FAJARDO, Víctor; QUIROZ, Andrés Identification of isoquinoline alkaloids from Berberis microphylla by HPLC ESI-MS/MS Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, vol. 13, núm. 4, 2014, pp. 324-335 Universidad de Santiago de Chile Santiago, Chile Available in: http://www.redalyc.org/articulo.oa?id=85631435002 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative © 2014 Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 13 (4): 324 - 335 ISSN 0717 7917 www.blacpma.usach.cl Artículo Original | Original Article In memorian Professor Luis Astudillo, Universidad de Talca, Chile Identification of isoquinoline alkaloids from Berberis microphylla by HPLC ESI-MS/MS [Identificación de alcaloides isoquinolínicos en Berberis microphylla G. Forst mediante CLAE IES-MS/MS] Loreto MANOSALVA1, Ana MUTIS2, Juan DÍAZ3, Alejandro URZÚA4, Víctor FAJARDO5 & Andrés QUIROZ2 1Doctorado en Ciencias de Recursos Naturales; 2Laboratorio de Ecología Química, Departamento de Ciencias Químicas y Recursos Naturales; 3Laboratory of Mass Spectrometry, Scientific and Technological Bioresource Nucleus (Bioren), Universidad de La Frontera, Temuco, Chile 4Laboratory of Chemical Ecology, Department of Environmental Sciences, Faculty of Chemistry and Biology, Universidad de Santiago de Chile 5Chile Laboratorio de Productos Naturales, Universidad de Magallanes, Punta Arenas, Chile Contactos | Contacts: Andrés QUIROZ - E-mail address: [email protected] Abstract: Berberis microphylla (G.
    [Show full text]
  • Diversity of the Mountain Flora of Central Asia with Emphasis on Alkaloid-Producing Plants
    diversity Review Diversity of the Mountain Flora of Central Asia with Emphasis on Alkaloid-Producing Plants Karimjan Tayjanov 1, Nilufar Z. Mamadalieva 1,* and Michael Wink 2 1 Institute of the Chemistry of Plant Substances, Academy of Sciences, Mirzo Ulugbek str. 77, 100170 Tashkent, Uzbekistan; [email protected] 2 Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany; [email protected] * Correspondence: [email protected]; Tel.: +9-987-126-25913 Academic Editor: Ipek Kurtboke Received: 22 November 2016; Accepted: 13 February 2017; Published: 17 February 2017 Abstract: The mountains of Central Asia with 70 large and small mountain ranges represent species-rich plant biodiversity hotspots. Major mountains include Saur, Tarbagatai, Dzungarian Alatau, Tien Shan, Pamir-Alai and Kopet Dag. Because a range of altitudinal belts exists, the region is characterized by high biological diversity at ecosystem, species and population levels. In addition, the contact between Asian and Mediterranean flora in Central Asia has created unique plant communities. More than 8100 plant species have been recorded for the territory of Central Asia; about 5000–6000 of them grow in the mountains. The aim of this review is to summarize all the available data from 1930 to date on alkaloid-containing plants of the Central Asian mountains. In Saur 301 of a total of 661 species, in Tarbagatai 487 out of 1195, in Dzungarian Alatau 699 out of 1080, in Tien Shan 1177 out of 3251, in Pamir-Alai 1165 out of 3422 and in Kopet Dag 438 out of 1942 species produce alkaloids. The review also tabulates the individual alkaloids which were detected in the plants from the Central Asian mountains.
    [Show full text]
  • Synthesis of Novel Compounds Based on Reticuline Scaffold for New Drugs Discovery Tam-Dan Batenburg-Nguyen University of Wollongong
    University of Wollongong Research Online University of Wollongong Thesis Collection University of Wollongong Thesis Collections 2005 Synthesis of novel compounds based on reticuline scaffold for new drugs discovery Tam-Dan Batenburg-Nguyen University of Wollongong Recommended Citation Batenburg-Nguyen, Tam-Dan, Synthesis of novel compounds based on reticuline scaffold for new drugs discovery, Doctor of Philosophy thesis, Department of Chemistry, Faculty of Science, University of Wollongong, 2005. http://ro.uow.edu.au/theses/1190 Research Online is the open access institutional repository for the University of Wollongong. For further information contact Manager Repository Services: [email protected]. Synthesis of Novel Compounds Based on the Reticuline Scaffold for New Drugs Discovery. A thesis submitted in fulfilment of the requirements for the award of the degree of Doctor of Philosophy From University of Wollongong Tam-Dan (Uta) Batenburg-Nguyen B. Adv. Med Chem (Hons) Department of Chemistry University of Wollongong Wollongong, Australia December, 2005 i Declaration I, Tam-Dan (Uta) Batenburg-Nguyen hereby declare that all materials presented in this thesis, submitted in the fulfillment of the requirements for the award of Doctor of Philosophy, in the Department of Chemistry, University of Wollongong, are exclusively of my own work. These materials have not been submitted for qualifications at any other academic institution, unless otherwise referenced or acknowledged. Tam-Dan (Uta) Batenburg-Nguyen December, 2005 ii Table of Contents DECLARATION…………………………………………………………………………… i LIST OF FIGURES………………………………………………………………………….xi LIST OF SCHEMES…………………………………………………………………xiv LIST OF TABLES………………………………………………………………………… .xx LIST OF ABBREVIATIONS…………………………………………………………… xxii ABSTRACT…………………………………………………………………………… xxviii ACKNOWLEDGEMENTS……………………………………………………………… xxxii CHAPTER 1 INTRODUCTION ............................................................................... 1 1.1. HISTORY OF NATURAL PRODUCTS. .............................................................. 2 1.2.
    [Show full text]
  • WO 2016/149821 Al 29 September 2016 (29.09.2016) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/149821 Al 29 September 2016 (29.09.2016) P O P C T (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C12N 9/02 (2006.01) C12N 15/81 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, C12N 1/19 (2006.01) C12N 9/04 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C12N 15/53 (2006.01) CI2P 17/10 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, C12N 15/54 (2006.01) C12P 17/12 (2006.01) KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (21) International Application Number: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, PCT/CA2016/050334 SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (22) International Filing Date: TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 23 March 2016 (23.03.2016) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (26) Publication Language: English TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (30) Priority Data: TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 62/136,912 23 March 2015 (23.03.2015) US DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) Applicant: VALORBEC SOCIETE EN COMMAN¬ SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, DITE [CA/CA]; 355 Peel, Carrefour INGO, Suite 503, GW, KM, ML, MR, NE, SN, TD, TG).
    [Show full text]
  • Modulatory Effects of Eschscholzia Californica Alkaloids on Recombinant GABAA Receptors
    Hindawi Publishing Corporation Biochemistry Research International Volume 2015, Article ID 617620, 9 pages http://dx.doi.org/10.1155/2015/617620 Research Article Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors Milan Fedurco,1 Jana Gregorová,2 Kristýna Šebrlová,2 Jana Kantorová,2 Ondlej Peš,2 Roland Baur,3 Erwin Sigel,3 and Eva Táborská2 1 Michelin Recherche et Technique S.A., Route Andre-Piller´ 30, 1762 Givisiez, Switzerland 2Department of Biochemistry, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic 3Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse¨ 28, 3012 Bern, Switzerland Correspondence should be addressed to Milan Fedurco; [email protected] Received 28 July 2015; Revised 5 September 2015; Accepted 15 September 2015 Academic Editor: Emanuel Strehler Copyright © 2015 Milan Fedurco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries. However, our understanding of these biological effects at the molecular level is still lacking. Alkaloids detected in E. californica could be hypothesized to act at GABAA receptors, which are widely expressed in the brain mainly at the inhibitory interneurons. Electrophysiological studies on a recombinant 1 2 2 GABAA receptor showed no effect of N-methyllaurotetanine at concentrations lower than 30 M. However, ()-reticuline behaved as positive allosteric modulator at the 3, 5,and6 isoforms of GABAA receptors.
    [Show full text]
  • Research Article Modulatory Effects of Eschscholzia Californica Alkaloids on Recombinant GABAA Receptors
    Hindawi Publishing Corporation Biochemistry Research International Volume 2015, Article ID 617620, 9 pages http://dx.doi.org/10.1155/2015/617620 Research Article Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors Milan Fedurco,1 Jana Gregorová,2 Kristýna Šebrlová,2 Jana Kantorová,2 Ondlej Peš,2 Roland Baur,3 Erwin Sigel,3 and Eva Táborská2 1 Michelin Recherche et Technique S.A., Route Andre-Piller´ 30, 1762 Givisiez, Switzerland 2Department of Biochemistry, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic 3Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse¨ 28, 3012 Bern, Switzerland Correspondence should be addressed to Milan Fedurco; [email protected] Received 28 July 2015; Revised 5 September 2015; Accepted 15 September 2015 Academic Editor: Emanuel Strehler Copyright © 2015 Milan Fedurco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries. However, our understanding of these biological effects at the molecular level is still lacking. Alkaloids detected in E. californica could be hypothesized to act at GABAA receptors, which are widely expressed in the brain mainly at the inhibitory interneurons. Electrophysiological studies on a recombinant 1 2 2 GABAA receptor showed no effect of N-methyllaurotetanine at concentrations lower than 30 M. However, ()-reticuline behaved as positive allosteric modulator at the 3, 5,and6 isoforms of GABAA receptors.
    [Show full text]