Table S1. Differentially expressed in TAM-/- and WT testis. expression patterns were analyzed with GeneChip® Mouse Genome 430/2.0 (Affymetrix, Santa Clara, CA). The pooled RNAs of testes from 3 mice each genotype were subjected to microarray analysis.

Up-regulated genes in TAM-/- testis.

Signal intensity Gene Title Gene Symbol UniGene ID Fold Change Function KO N 1 RIKEN cDNA 1700097M23 gene 1700097M23Rik Mm.399360 116.83 2.48 47.02 unkown 2 fatty acid binding 9, testis Fabp9 Mm.26654 1219.27 45.72 26.67 transport 3 RIKEN cDNA 1700008K24 gene 1700008K24Rik Mm.46140 741.94 32.07 23.14 unkown 4 lactate dehydrogenase C Ldhc Mm.16563 1226.78 54.47 22.52 oxidation reduction a disintegrin and metallopeptidase 5 Adam2 Mm.422850 253.45 12.29 20.62 proteolysis domain 2 6 lactate dehydrogenase A-like 6B Ldhal6b Mm.432764 374.12 22.19 16.86 glycolysis 7 RIKEN cDNA 1700016M24 gene 1700016M24Rik Mm.263708 394.98 24.51 16.12 unkown 8 RIKEN cDNA 4930550L11 gene 4930550L11Rik Mm.391968 908.55 56.46 16.09 unkown 9 interferon activated gene 202B Ifi202b Mm.218770 55.32 3.63 15.24 immune response induction of apoptosis by 10 tumor necrosis factor α Tnf α Mm.1293 1383.03 99.47 13.9 extracellular signals 11 phosducin-like 2 Pdcl2 Mm.143764 571.17 42.49 13.44 phototransduction 12 RIKEN cDNA 1700029M20 gene 1700029M20Rik Mm.292326 665.07 62.07 10.72 unkown 13 RIKEN cDNA 1700102P08 gene 1700102P08Rik Mm.78287 1263.87 118.99 10.62 unkown 14 T-cell specific GTPase Tgtp --- 505.8 59.76 8.46 immune response 15 dickkopf-like 1 Dkkl1 Mm.27287 181.48 21.99 8.25 morphogenesis cell differentiation 16 piwi-like homolog 1 (Drosophila) Piwil1 Mm.272720 335.79 41.38 8.11 multicellular organismal development spermatogenesis 17 RIKEN cDNA 4933415F23 gene 4933415F23Rik Mm.431297 98.79 12.54 7.88 unkown 18 hematopoietic cell transcript 1 Hemt1 Mm.17336 1671.61 212.16 7.88 biological process regulatory factor X, 4 (influences regulation of 19 Rfx4 Mm.79070 121.92 16.56 7.36 HLA class II expression) transcription 20 testicular cell adhesion molecule 1 Tcam1 Mm.159608 500.07 69.31 7.21 cell-cell adhesion 21 Transcribed locus --- Mm.399255 137.73 20.65 6.67 unkown 22 RIKEN cDNA 4930442P07 gene 4930442P07Rik Mm.395790 286.3 43.06 6.65 unkown 23 RIKEN cDNA 1700019P01 gene 1700019P01Rik Mm.86807 231.77 35.97 6.44 protein modification 24 glycerol kinase 2 Gk2 Mm.61206 128.1 20.31 6.31 unkown 25 testis specific gene A2 Tsga2 Mm.12743 2605.37 415.52 6.27 meiosis 26 RIKEN cDNA 1700006J14 gene 1700006J14Rik Mm.391448 126.27 20.46 6.17 unkown 27 GLI pathogenesis-related 1 like 2 Glipr1l2 Mm.292351 297.03 49.34 6.02 unkown multicellular organismal 28 sperm equatorial segment protein 1 Spesp1 Mm.263615 553.24 93.21 5.94 development 29 RIKEN cDNA 1700019A02 gene 1700019A02Rik Mm.307084 332.77 56.05 5.94 unkown 30 dynein, axonemal, heavy chain 7 Dnahc7 Mm.184692 118.79 20.26 5.86 biological process 31 Ly6/Plaur domain containing 4 Lypd4 Mm.189648 244.52 42.27 5.78 unkown regulation of transcription 32 gene model 739 Gm739 Mm.390371 262.86 46.41 5.66 transcription 33 RIKEN cDNA 1700100I10 gene 1700100I10Rik --- 99.25 17.59 5.64 unkown vesicle docking during 34 pallidin Pldn Mm.268921 84.2 14.97 5.63 exocytosis 35 hypothetical protein 9530028C05 9530028C05 --- 272.69 48.49 5.62 unkown 36 RIKEN cDNA 1700010I14 gene 1700010I14Rik Mm.67591 149.49 27.4 5.46 unkown cell differentiation metallothionein-like 5, multicellular organismal 37 Mtl5 Mm.209941 621.12 116.56 5.33 testis-specific (tesmin) development spermatogenesis 38 arylsulfatase K Arsk Mm.196399 108.04 20.29 5.32 biological process pyruvate dehydrogenase E1 alpha metabolic process 39 Pdha2 Mm.4223 864.58 162.69 5.31 2 oxidation reduction 40 RIKEN cDNA 1700010A17 gene 1700010A17Rik Mm.276332 461.89 87.22 5.3 unkown 41 F-box protein 39 Fbxo39 Mm.291131 650.19 124.97 5.2 cell cycle EP300 interacting inhibitor of 42 Eid3 Mm.399104 84.02 16.67 5.04 unkown differentiation 3 43 microrchidia 2B Morc2b Mm.157765 103.78 21.02 4.94 unkown cell differentiation multicellular organismal 44 calmegin Clgn Mm.358581 182.22 37.21 4.9 development spermatogenesis 45 patched domain containing 3 Ptchd3 Mm.61213 95.21 19.46 4.89 unkown cytochrome c oxidase subunit VIb 46 Cox6b2 Mm.29625 1299.49 271.02 4.79 biological process polypeptide 2 47 cDNA sequence AK162044 AK162044 Mm.54257 83.97 17.91 4.69 unkown 48 ankyrin repeat domain 48 Ankrd48 Mm.67300 155.6 33.39 4.66 regulation of transcription 49 coiled-coil domain containing 96 Ccdc96 Mm.42368 156.8 36.23 4.33 unkown cytokine and chemokine 50 interferon inducible GTPase 1 Iigp1 Mm.261140 334.93 78.64 4.26 mediated signaling pathway 51 Y box protein 2 Ybx2 Mm.29286 321.83 75.65 4.25 regulation of transcription 52 sperm equatorial segment protein 1 Spesp1 Mm.263615 63.56 14.96 4.25 multicellular organismal development 53 kallikrein 1-related peptidase b24 Klk1b24 --- 63.57 15.04 4.23 proteolysis ubiquitin-conjugating enzyme E2U 54 Ube2u Mm.318133 81.89 19.38 4.23 unkown (putative) hepatoma derived growth 55 Hdgfl1 Mm.7411 309.04 74.42 4.15 unkown factor-like 1 CKLF-like MARVEL 56 transmembrane domain containing Cmtm2a Mm.272746 32.85 7.94 4.14 chemotaxis 2A 57 RIKEN cDNA 1700097N02 gene 1700097N02Rik Mm.372315 194.28 47.13 4.12 unkown 58 RIKEN cDNA 4931428L18 gene 4931428L18Rik Mm.161414 77.07 18.77 4.11 unkown 59 ring finger protein 32 Rnf32 Mm.87352 562.29 140.49 4 biological process cytokine and chemokine 60 interferon inducible GTPase 1 Iigp1 Mm.261140 296.81 75.18 3.95 mediated signaling pathway 61 meiosis expressed gene 1 Meig1 Mm.2688 1788.99 454.31 3.94 meiosis cytochrome c oxidase, subunit 62 Cox8c Mm.660 1217.13 308.73 3.94 unkown VIIIc 63 RIKEN cDNA 1700010I14 gene 1700010I14Rik Mm.67591 160.24 41.13 3.9 unkown hydroxy-delta-5-steroid 64 dehydrogenase, 3 beta- and steroid Hsd3b2 Mm.196405 101.52 26.21 3.87 steroid biosynthesis delta-isomerase 2 65 ropporin 1-like Ropn1l Mm.434609 854.52 233.1 3.67 signal transduction hydroxyacid oxidase (glycolate metabolic process 66 Hao3 Mm.281874 725.56 200.01 3.63 oxidase) 3 oxidation reduction proteasome (prosome, macropain) 67 Psma8 Mm.87277 1324.66 364.71 3.63 proteolysis subunit, alpha type, 8 interferon gamma inducible protein 68 Ifi47 Mm.24769 399.13 111.62 3.58 signal transduction 47 69 synaptogyrin 4 Syngr4 Mm.367349 396.59 113.12 3.51 unkown guanylate nucleotide binding 70 Gbp2 Mm.24038 153.87 44.03 3.49 unkown protein 2 71 RIKEN cDNA 2610020H08 gene 2610020H08Rik Mm.38237 1987.13 569.34 3.49 unkown 72 serine/threonine kinase 33 Stk33 Mm.389950 260.09 74.86 3.47 protein phosphorylation 73 RIKEN cDNA 4930511M11 gene 4930511M11Rik Mm.85064 60.39 17.51 3.45 unkown 74 RIKEN cDNA 4930524B15 gene 4930524B15Rik Mm.78654 206.05 60.62 3.4 unkown 75 predicted gene, EG668339 EG668339 Mm.394985 2433.47 715.8 3.4 unkown general transcription factor II A, regulation of transcription 76 Gtf2a1lf Mm.61330 135.94 40.11 3.39 1-like factor transcription 77 RIKEN cDNA 1700104B16 gene 1700104B16Rik Mm.160107 72.08 21.47 3.36 unkown 78 RIKEN cDNA 1700049M11 gene 1700049M11Rik Mm.142735 664.63 198.46 3.35 unkown Leucine rich repeat containing 6 79 Lrrc6 Mm.244890 50.26 15.01 3.35 biological process (testis) hypothetical gene supported by 80 LOC434089 Mm.101361 163.59 49.34 3.32 unkown AK039686 81 phosphodiesterase 10A Pde10a Mm.87161 27.31 8.24 3.31 signal transduction regulation of transcription 82 tripartite motif protein 30 Trim30 Mm.295578 22.52 6.88 3.27 transcription one-carbon compound 83 carbonic anhydrase 7 Car7 Mm.129265 575.53 176.91 3.25 metabolism cell differentiation metallothionein-like 5, 84 Mtl5 Mm.209941 1087.73 339.63 3.2 multicellular organismal testis-specific (tesmin) development spermatogenesis regulation of transcription, 85 RIKEN cDNA 1700029I01 gene 1700029I01Rik Mm.392861 67.59 21.15 3.2 DNA-dependent 86 Adult male testis cDNA --- Mm.417665 63.63 19.89 3.2 unkown 87 chemokine (C-C motif) receptor 5 Ccr5 Mm.425007 57.47 18.1 3.17 chemotaxis leucine rich repeat containing 6 88 Lrrc6 Mm.244890 146.46 46.91 3.12 unkown (testis) 89 coiled-coil domain containing 89 Ccdc89 Mm.307198 39.89 12.8 3.12 unkown 90 REC8-like 1 (yeast) Rec8L1 Mm.23149 615.51 198.83 3.1 meiosis 91 interferon activated gene 203 Ifi203 Mm.261270 44.34 14.43 3.07 immune response 92 RIKEN cDNA 4932415G12 gene 4932415G12Rik Mm.116284 627.42 204.57 3.07 unkown neural precursor cell expressed, 93 developmentally down-regulted Nedd4 Mm.279923 1424.98 465.88 3.06 protein modification gene 4 splicing factor, arginine/serine-rich 94 Sfrs14 Mm.284505 1739.86 571.45 3.04 mRNA processing 14 regulation of transcription 95 jumonji domain containing 2D Jmjd2d Mm.240457 163.46 53.86 3.04 oxidation reduction transcription regulation of transcription 96 E2F transcription factor 6 E2f6 Mm.23296 129.86 42.81 3.03 cell cycle transcription regulation of transcription, 97 PHD finger protein 7 Phf7 Mm.5348 370.91 123 3.02 DNA-dependent 98 heat shock protein 2 Hspa2 Mm.296181 1484.35 492.46 3.01 protein folding 99 RIKEN cDNA 1700025K23 gene 1700025K23Rik Mm.45187 620.94 208.17 2.98 unkown 100 centrin 1 Cetn1 Mm.195831 79.36 26.69 2.97 cell cycle myosin, heavy polypeptide 1, 101 Myh1 Mm.422801 106.53 36.15 2.95 striated muscle contraction skeletal muscle, adult DnaJ (Hsp40) homolog, subfamily 102 Dnajb6 Mm.290110 422.28 143.45 2.94 protein folding B, member 6 lymphocyte antigen 6 complex, 103 Ly6k Mm.273319 2210.27 752.67 2.94 unkown locus K ubiquitin-dependent protein 104 ubiquitin specific peptidase 18 Usp18 Mm.326911 152.27 52.68 2.89 catabolism 105 leucine rich repeat containing 34 Lrrc34 Mm.45373 125.39 43.72 2.87 unkown antigen processing and Histocompatibility 2, class II 106 H2-Aa Mm.235338 96.86 33.77 2.87 presentation of peptide antigen antigen A, alpha via MHC class I biological process cell differentiation 107 spermatogenesis associated 16 Spata16 Mm.330943 39.02 13.71 2.85 multicellular organismal development spermatogenesis 108 Transcribed locus --- Mm.270164 74.41 26.08 2.85 unkown 109 sperm autoantigenic protein 17 Spa17 Mm.8637 1301.34 463.03 2.81 signal transduction 110 RIKEN cDNA C330002I19 gene C330002I19Rik Mm.250641 228.49 81.29 2.81 regulation of transcription 111 abhydrolase domain containing 1 Abhd1 Mm.389615 129.93 46.37 2.8 biological process 112 RIKEN cDNA 4933425E08 gene 4933425E08Rik --- 94.97 34.08 2.79 unkown regulation of transcription 113 SRY-box containing gene 30 Sox30 Mm.66708 105.13 37.7 2.79 transcription 114 RIKEN cDNA 1700013G23 gene 1700013G23Rik Mm.383770 169.25 60.78 2.78 unkown serine peptidase inhibitor, Kazal 115 Spink2 Mm.46106 108 38.91 2.78 unkown type 2 aldo-keto reductase family 1, 116 Akr1b7 Mm.90151 367.88 133.96 2.75 cellular lipid metabolism member B7 117 RIKEN cDNA 9330102E08 gene 9330102E08Rik Mm.426356 473.68 172.95 2.74 unkown 118 RIKEN cDNA A330021E22 gene A330021E22Rik Mm.319007 175.3 64.24 2.73 unkown 119 predicted gene, EG639426 EG639426 Mm.84118 56.78 20.83 2.73 unkown meiosis 120 mutS homolog 4 (E. coli) Msh4 Mm.272226 179.57 65.9 2.72 spermatogenesis 121 leucine rich repeat containing 27 Lrrc27 Mm.17757 498.24 185.12 2.69 unkown 122 RIKEN cDNA 6530404N21 gene 6530404N21Rik Mm.204591 545.44 203.36 2.68 unkown 123 RIKEN cDNA 4930521A18 gene 4930521A18Rik Mm.246796 44.8 16.76 2.67 unkown t-complex-associated testis 124 Tcte3 Mm.260474 1010.58 380.13 2.66 microtubule-based movement expressed 3 125 5-oxoprolinase (ATP-hydrolysing) Oplah Mm.393455 122.43 46.34 2.64 unkown regulation of transcription 126 bromodomain, testis-specific Brdt Mm.182836 280.03 106.07 2.64 transcription 127 Transcribed locus --- Mm.404285 99.16 37.57 2.64 unkown 128 RIKEN cDNA 4733401H18 gene 4733401H18Rik Mm.29471 975.15 370.59 2.63 unkown 129 insulin-like 6 Insl6 Mm.306511 162.27 61.84 2.62 unkown serine (or cysteine) peptidase 130 Serpina3n Mm.22650 122.68 46.76 2.62 acute-phase response inhibitor, clade A, member 3N Cbp/p300-interacting regulation of transcription 131 transactivator, with Glu/Asp-rich Cited4 Mm.272646 329.5 125.87 2.62 transcription carboxy-terminal domain, 4 132 RIKEN cDNA 4930511M11 gene 4930511M11Rik Mm.85064 60.19 23.08 2.61 unkown 133 RIKEN cDNA 2010007H12 gene 2010007H12Rik Mm.276058 286 110.11 2.6 unkown 134 fructose bisphosphatase 1 Fbp1 Mm.423078 177.04 69.12 2.56 carbohydrate metabolism 135 leucine rich repeat containing 46 Lrrc46 Mm.250465 228.1 89.98 2.54 unkown CKLF-like MARVEL 136 transmembrane domain containing Cmtm2a Mm.272746 33.52 13.22 2.54 chemotaxis 2A proteosome (prosome, macropain) 137 subunit, beta type 8 (large Psmb8 Mm.180191 313.13 125.93 2.49 proteolysis multifunctional peptidase 7) 138 RIKEN cDNA 1700010B08 gene 1700010B08Rik Mm.308031 126.15 50.63 2.49 unkown superkiller viralicidic activity 139 Skiv2l2 Mm.291029 58.56 23.49 2.49 mRNA processing 2-like 2 (S. cerevisiae) transcription elongation factor A regulation of transcription 140 Tcea2 Mm.24245 790.31 319.3 2.48 (SII), 2 transcription multicellular organismal 141 Tnf receptor associated factor 4 Traf4 Mm.390418 578.13 233.03 2.48 development signal transduction 142 coiled-coil domain containing 39 Ccdc39 Mm.432469 61.64 24.9 2.48 unkown kinase non-catalytic C-lobe 143 Kndc1 Mm.44442 127.84 51.84 2.47 biological process domain (KIND) containing 1 144 interferon gamma induced GTPase Igtp Mm.33902 665.62 270.33 2.46 unkown 145 endothelial precursor protein B9 Eppb9 Mm.261226 945.58 383.96 2.46 biological process regulation of transcription, 146 PHD finger protein 7 Phf7 Mm.5348 2544.8 1036.01 2.46 DNA-dependent 147 RIKEN cDNA 1700037C18 gene 1700037C18Rik Mm.28403 59.7 24.36 2.45 unkown 148 dynein, axonemal, heavy chain 7c Dnahc7c Mm.296880 207.43 84.74 2.45 microtubule-based movement 149 RIKEN cDNA 4930463O16 gene 4930463O16Rik Mm.159580 99.97 40.98 2.44 unkown 150 macrophage activation 2 like Mpa2l Mm.275893 146.82 60.08 2.44 immune response 151 receptor transporter protein 4 Rtp4 Mm.434399 423.29 174.06 2.43 unkown fibronectin type 3 and ankyrin 152 Fank1 Mm.87448 186.71 77.16 2.42 regulation of transcription repeat domains 1 cell differentiation metallothionein-like 5, multicellular organismal 153 Mtl5 Mm.209941 110.05 45.42 2.42 testis-specific (tesmin) development spermatogenesis 154 Park2 co-regulated Pacrg Mm.18889 312.06 129.67 2.41 biological process megalencephalic leukoencephalopathy with 155 Mlc1 Mm.32780 176.12 73.22 2.41 transport subcortical cysts 1 homolog (human) complement component 1, q 156 C1qb Mm.2570 579.42 241.26 2.4 defense response subcomponent, beta polypeptide regulation of transcription doublesex and mab-3 related biological process 157 Dmrtc2 Mm.66855 200.27 83.99 2.38 transcription factor like family C2 cell differentiation transcription antigen processing and histocompatibility 2, class II 158 H2-Aa Mm.235338 676.8 285.04 2.37 presentation of peptide antigen antigen A, alpha via MHC class I 159 leucine rich repeat containing 50 Lrrc50 Mm.432018 324.26 136.73 2.37 unkown myosin, heavy polypeptide 1, 160 Myh1 Mm.422801 111.98 47.43 2.36 striated muscle contraction skeletal muscle, adult 161 cytochrome c, testis Cyct Mm.4872 968.88 410.4 2.36 transport 162 RIKEN cDNA 1700012H05 gene 1700012H05Rik Mm.128134 255.9 108.56 2.36 regulation of transcription 163 HORMA domain containing 2 Hormad2 Mm.159592 328.24 139.27 2.36 biological process microtubule cytoskeleton 164 tektin 1 Tekt1 Mm.42257 165.68 70.5 2.35 organization and biogenesis solute carrier family 4 (anion 165 Slc4a1 Mm.7248 46.54 19.77 2.35 transport exchanger), member 1 splicing factor, arginine/serine-rich 166 Sfrs14 Mm.284505 311.98 133 2.35 mRNA processing 14 167 sclerostin Sost Mm.265602 160.14 68.07 2.35 ossification 168 RIKEN cDNA 4930404A10 gene 4930404A10Rik Mm.390370 137.38 58.58 2.35 unkown hepatoma derived growth 169 Hdgfl1 Mm.7411 54.37 23.28 2.34 unkown factor-like 1 regulation of transcription, 170 PHD finger protein 7 Phf7 Mm.5348 900.52 385.32 2.34 DNA-dependent guanylate nucleotide binding 171 Gbp2 Mm.24038 221.07 94.98 2.33 unkown protein 2 172 testis expressed gene 101 Tex101 Mm.23385 5451.06 2352.12 2.32 unkown 173 SRY-box containing gene 11 Sox11 Mm.428745 78.99 34.06 2.32 transcription zinc finger, MYND domain 174 Zmynd12 Mm.388911 134.38 57.82 2.32 biological process containing 12 175 cysteine-rich secretory protein 2 Crisp2 Mm.1296 184.05 79.65 2.31 unkown t-complex-associated testis 176 Tcte3 Mm.260474 3902.44 1686.8 2.31 microtubule-based movement expressed 3 regulation of transcription, 177 PHD finger protein 7 Phf7 Mm.5348 430.52 187.23 2.3 DNA-dependent solute carrier family 2 (facilitated 178 Slc2a3 Mm.395108 682.43 297.13 2.3 transport glucose transporter), member 3 179 RIKEN cDNA 1700023A16 gene 1700023A16Rik Mm.252733 50.64 22.04 2.3 unkown 180 predicted gene, EG432879 EG432879 Mm.308666 467.93 203.27 2.3 unkown cell differentiation multicellular organismal 181 ring finger protein 17 Rnf17 Mm.287783 284.72 123.63 2.3 development spermatogenesis arachidonate 5-lipoxygenase 182 Alox5ap Mm.19844 358.83 156.92 2.29 leukotriene metabolism activating protein proprotein convertase neuropeptide signaling 183 Pcsk1n Mm.4881 1353.56 594.9 2.28 subtilisin/kexin type 1 inhibitor pathway 184 RIKEN cDNA 0610037M15 gene 0610037M15Rik --- 184.87 81.14 2.28 unkown malate dehydrogenase 1B, NAD metabolic process 185 Mdh1b Mm.30494 131.98 57.85 2.28 (soluble) oxidation reduction 186 RIKEN cDNA 4930451C15 gene 4930451C15Rik Mm.38634 56.95 25.02 2.28 unkown metabolic process 187 carbonyl reductase 2 Cbr2 Mm.21454 1230.67 542.94 2.27 oxidation reduction 188 dipeptidase 3 Dpep3 Mm.173395 535.32 236.14 2.27 proteolysis 189 senataxin Setx Mm.41867 198.84 87.52 2.27 biological process betaine-homocysteine 190 Bhmt Mm.329582 174.09 76.91 2.26 protein amino acid methylation methyltransferase 191 gene model 1337, (NCBI) Gm1337 Mm.35758 93.19 41.2 2.26 unkown 192 coiled-coil domain containing 92 Ccdc92 Mm.389693 402 178.72 2.25 unkown 193 RIKEN cDNA 2310007A19 gene 2310007A19Rik Mm.46405 68.32 30.34 2.25 unkown 194 zinc finger and BTB domain Zbtb3 Mm.23423 148.97 66.41 2.24 regulation of transcription containing 3 transcription 195 RIKEN cDNA C330002I19 gene C330002I19Rik Mm.250641 34.84 15.54 2.24 regulation of transcription 196 protocadherin 8 Pcdh8 Mm.390715 58.55 26.09 2.24 somitogenesis 197 vanin 1 Vnn1 Mm.27154 312.03 139.19 2.24 defense response cell differentiation multicellular organismal 198 expressed in non-metastatic cells 5 Nme5 Mm.275430 211.69 94.84 2.23 development spermatogenesis 199 RIKEN cDNA 1700052N19 gene 1700052N19Rik Mm.346733 524.45 235.21 2.23 electron transport 200 steroid 5 alpha-reductase 1 Srd5a1 Mm.422833 321.47 144.19 2.23 androgen biosynthesis 201 RIKEN cDNA 4930503B16 gene 4930503B16Rik Mm.60690 1752.27 790.95 2.22 electron transport 202 insulin-like 3 /// Janus kinase 3 Insl3 /// Jak3 Mm.249645 3270.59 1481.85 2.21 protein phosphorylation 203 RIKEN cDNA 4930513N10 gene 4930513N10Rik Mm.386996 41.67 18.81 2.21 unkown membrane-spanning 4-domains, 204 Ms4a6d Mm.290390 282.28 128.22 2.2 signal transduction subfamily A, member 6D 205 tudor domain containing 5 Tdrd5 Mm.252800 278.14 126.25 2.2 unkown 206 WD repeat domain 31 Wdr31 Mm.155573 161.87 73.73 2.2 transport 207 testis specific gene A8 Tsga8 Mm.383210 232.03 105.98 2.19 biological process 208 RIKEN cDNA 4930430A15 gene 4930430A15Rik Mm.84331 14.6 6.68 2.19 regulation of transcription 209 RIKEN cDNA E130303B06 gene E130303B06Rik Mm.276087 175.74 80.41 2.19 unkown cell differentiation DNA segment, Chr 1, Pasteur multicellular organismal 210 D1Pas1 Mm.108054 215.23 98.29 2.19 Institute 1 development spermatogenesis complement component 1, q 211 C1qb Mm.2570 446.99 204.3 2.19 defense response subcomponent, beta polypeptide 212 RIKEN cDNA 1700019N12 gene 1700019N12Rik Mm.251306 60.99 27.83 2.19 unkown 213 RIKEN cDNA 4933416C03 gene 4933416C03Rik Mm.391427 718.28 327.65 2.19 regulation of transcription 214 RIKEN cDNA 4930465K10 gene 4930465K10Rik Mm.391126 64.44 29.38 2.19 unkown 215 Ring finger protein 182 Rnf182 Mm.40588 42.58 19.55 2.18 ubiquitin cycle 216 RIKEN cDNA 4921537D05 gene 4921537D05Rik Mm.296971 332.05 153.08 2.17 unkown 217 acyl-CoA thioesterase 7 Acot7 Mm.296191 2013.03 932.78 2.16 fatty acid metabolism abhydrolase domain containing 218 Abhd14a Mm.268925 1053.11 487.69 2.16 biological process 14A 219 RIKEN cDNA 1500011H22 gene 1500011H22Rik Mm.422712 2128.36 990.53 2.15 unkown cell differentiation tumor necrosis factor, 220 Tnfaip2 Mm.255332 185.25 85.99 2.15 multicellular organismal alpha-induced protein 2 development antigen processing and Histocompatibility 2, class II 221 H2-Aa Mm.235338 443.44 206.63 2.15 presentation of peptide antigen antigen A, alpha via MHC class I 222 RIKEN cDNA 1700040D17 gene 1700040D17Rik Mm.87305 68.27 31.73 2.15 unkown longevity assurance homolog 5 (S. 223 Lass5 Mm.390821 154.28 71.86 2.15 regulation of transcription cerevisiae) zinc finger and BTB domain regulation of transcription 224 Zbtb32 Mm.116789 607.79 283.59 2.14 containing 32 transcription 225 RIKEN cDNA 4930573O21 gene 4930573O21Rik --- 40.5 18.94 2.14 unkown 226 RIKEN cDNA 4933403G14 gene 4933403G14Rik Mm.41709 131.51 61.6 2.14 unkown 227 sperm associated antigen 6 Spag6 --- 63.19 29.66 2.13 spermatogenesis multicellular organismal 228 Moloney leukemia virus 10-like 1 Mov10l1 Mm.358791 847.45 397.06 2.13 development 229 chemokine-like factor Cklf Mm.269219 841.3 395.14 2.13 chemotaxis solute carrier family 2 (facilitated 230 Slc2a3 Mm.395108 901.57 423.93 2.13 transport glucose transporter), member 3 membrane-spanning 4-domains, 231 Ms4a4d --- 489.51 231.18 2.12 signal transduction subfamily A, member 4D 232 RIKEN cDNA 4930413O22 gene 4930413O22Rik Mm.244046 140.41 66.33 2.12 unkown 233 F-box protein 15 Fbxo15 Mm.28369 341.74 160.89 2.12 ubiquitin cycle 234 similar to zinc finger protein 541 LOC638394 Mm.290718 311.71 147.11 2.12 unkown polyadenylate binding 235 Paip1 Mm.132584 163.8 77.37 2.12 biological process protein-interacting protein 1 236 elastase 3 Ela3 Mm.297477 28.01 13.27 2.11 proteolysis 237 RIKEN cDNA 4930578N16 gene 4930578N16Rik Mm.195726 84.66 40.12 2.11 unkown nicotinamide nucleotide 238 Nmnat3 Mm.294082 68.46 32.43 2.11 biosynthesis adenylyltransferase 3 239 cDNA sequence BC107230 BC107230 Mm.79114 97.6 46.24 2.11 proteolysis coiled-coil domain containing 240 Ccdc109b Mm.31056 99.2 47.13 2.1 unkown 109B abhydrolase domain containing 241 Abhd14a Mm.268925 365.52 174.13 2.1 biological process 14A 242 RIKEN cDNA 4732415M23 gene 4732415M23Rik Mm.258354 1390 661.11 2.1 unkown ATP-binding cassette, sub-family A 243 Abca16 Mm.334203 34.66 16.52 2.1 unkown (ABC1), member 16 antigen processing and histocompatibility 2, D region 244 H2-D1 Mm.33263 1499.25 717.39 2.09 presentation of peptide antigen locus 1 via MHC class I 245 centrin 1 Cetn1 Mm.195831 122.38 58.56 2.09 cell cycle 246 RIKEN cDNA 1700097N02 gene 1700097N02Rik Mm.372315 226.54 108.33 2.09 unkown 247 RIKEN cDNA 4930579G24 gene 4930579G24Rik Mm.221520 665.01 318.64 2.09 unkown 248 cDNA sequence BC030440 BC030440 Mm.251075 937.06 448.83 2.09 unkown cell division cycle 20 homolog (S. 249 Cdc20 Mm.289747 2145.06 1031.08 2.08 cell cycle cerevisiae) 250 chemokine-like factor Cklf Mm.269219 326.9 156.83 2.08 chemotaxis 251 zona pellucida binding protein Zpbp Mm.9500 154.53 74.31 2.08 biological process Coiled-coil-helix-coiled-coil-helix 252 Chchd3 Mm.21501 34.75 16.7 2.08 unkown domain containing 3 253 RIKEN cDNA A330021E22 gene A330021E22Rik Mm.319007 52.73 25.32 2.08 unkown 254 gene model 884, (NCBI) Gm884 Mm.380214 141.33 67.89 2.08 unkown regulation of transcription oligodendrocyte transcription multicellular organismal 255 Olig2 Mm.37289 30.6 14.81 2.07 factor 2 development transcription melanin biosynthesis from 256 D-dopachrome tautomerase Ddt Mm.298947 2126.25 1025.93 2.07 tyrosine ATP synthesis coupled proton 257 radial spokehead-like 2B Rshl2b Mm.359991 3117.31 1504.76 2.07 transport 258 calmodulin 3 Calm3 Mm.288630 1564.4 756.92 2.07 cell cycle 259 RIKEN cDNA 4921527H02 gene 4921527H02Rik --- 37.44 18.1 2.07 unkown lymphocyte antigen 6 complex, 260 Ly6d Mm.878 101.39 49.21 2.06 unkown locus D 261 RIKEN cDNA 4932702K14 gene 4932702K14Rik Mm.26987 55.92 27.11 2.06 unkown 262 cDNA sequence AK122209 AK122209 Mm.334891 336.28 162.89 2.06 unkown NIMA (never in mitosis gene cell cycle 263 Nek2 Mm.33773 750.14 363.63 2.06 a)-related expressed kinase 2 meiosis protein phosphorylation solute carrier family 35 264 (UDP-galactose transporter), Slc35a2 Mm.214976 407.62 197.56 2.06 transport member 2 265 IQ motif containing G Iqcg --- 70.2 34.07 2.06 physiological process 266 four and a half LIM domains 4 Fhl4 Mm.46163 126.87 61.87 2.05 biological process 267 cDNA sequence BC019943 BC019943 Mm.349800 394.04 192.01 2.05 unkown 268 RIKEN cDNA 2400006H24 gene 2400006H24Rik Mm.371612 1582.43 770.47 2.05 transport 269 chemokine-like factor Cklf Mm.269219 516.73 252.03 2.05 chemotaxis 270 interferon inducible GTPase 2 Iigp2 --- 270.83 132.92 2.04 biological process meiotic nuclear divisions 1 271 Mnd1 Mm.274829 236.55 115.87 2.04 meiosis homolog (S. cerevisiae) mitogen-activated protein kinase 8 272 Mapk8ip2 Mm.173337 150.64 74.22 2.03 MAPKKK cascade interacting protein 2 273 RIKEN cDNA 1700011M02 gene 1700011M02Rik Mm.46161 5839.92 2872.76 2.03 unkown 274 Transcribed locus --- Mm.394776 17.65 8.71 2.03 unkown 275 aquaporin 2 Aqp2 Mm.20206 359.82 178.55 2.02 transport 276 RIKEN cDNA 4930506L13 gene 4930506L13Rik Mm.282339 249 123.02 2.02 unkown StAR-related lipid transfer 277 Stard6 Mm.83623 262.54 129.77 2.02 transport (START) domain containing 6 antigen processing and 278 histocompatibility 2, D region H2-L --- 1723.82 855.17 2.02 presentation of peptide antigen via MHC class I 279 katanin p60 subunit A-like 2 Katnal2 Mm.35803 81.47 40.27 2.02 unkown metabolic process 280 L-threonine dehydrogenase Tdh Mm.354229 137.2 67.8 2.02 oxidation reduction 281 RIKEN cDNA 4930429F24 gene 4930429F24Rik Mm.262175 82.71 40.87 2.02 unkown metabolic process 282 retinol dehydrogenase 11 Rdh11 Mm.291799 253.9 126.37 2.01 oxidation reduction 283 vitrin Vit Mm.292983 160.27 79.57 2.01 unkown metabolic process 284 retinol dehydrogenase 11 Rdh11 Mm.291799 200.21 99.71 2.01 oxidation reduction 285 RIKEN cDNA 4933425L06 gene 4933425L06Rik Mm.109093 147.48 73.4 2.01 nucleotide catabolism 286 placenta specific 9 Plac9 Mm.33344 1922.73 956 2.01 biological process 287 RIKEN cDNA 1810007P19 gene 1810007P19Rik Mm.38907 513.44 255.87 2.01 transport

Down-regulated genes in TAM -/- testis.

Signal intensity Gene Title Gene Symbol UniGene ID Fold Change Function KO N 1 cysteine-rich secretory protein 1 Crisp1 Mm.16781 3.47 1266.02 -364.45 unkown serine peptidase inhibitor, Kazal 2 Spink8 Mm.99613 39.25 1757.93 -44.79 unkown type 8 3 defensin beta 42 Defb42 Mm.387101 37.79 1011.86 -26.78 unkown spermatogenesis associated 5-like 4 Spata5l1 Mm.271306 13.21 202.6 -15.33 unkown 1 5 Arrestin domain containing 3 Arrdc3 Mm.423137 15.47 223.56 -14.45 biological process serine (or cysteine) peptidase 6 Serpina1f Mm.20149 7.28 79.93 -10.97 unkown inhibitor, clade A, member 1f 7 Mer receptor tyrosine kinase Mertk Mm.239655 21.64 218.97 -10.12 8 defensin beta 1 Defb1 Mm.431316 12.8 127.34 -9.95 defense response 9 N-cadherin16 Cdh16 Mm.19423 134.21 1278.98 -9.53 10 AXL receptor tyrosine kinase Axl Mm.4128 127.81 1178.3 -9.22 protein phosphorylation serine peptidase inhibitor, Kazal negative regulation of 11 Spink12 Mm.99782 10.89 99.2 -9.11 type 11 proteolysis 12 defensin beta 2 Defb2 Mm.41981 24.81 222.71 -8.98 defense response multicellular organismal 13 chordin-like 1 Chrdl1 Mm.157697 8.29 68.61 -8.28 development cell differentiation 14 defensin beta 29 Defb29 Mm.45560 38.84 318.03 -8.19 defense response CEA-related cell adhesion 15 Ceacam10 Mm.30300 8.35 63.86 -7.65 unkown molecule 10 calcium-independent cell-cell 16 claudin 8 Cldn8 Mm.25836 11.45 86.23 -7.53 adhesion transport 17 CD36 antigen Cd36 Mm.18628 37.84 277.39 -7.33 cell adhesion CUB and zona pellucida-like cell adhesion 18 Cuzd1 Mm.142717 94.62 671.6 -7.1 domains 1 cell cycle 19 TYRO3 protein tyrosine kinase 3 Tyro3 Mm.2901 111.59 652.72 -5.85 protein phosphorylation 2900056M20R 20 RIKEN cDNA 2900056M20 gene Mm.254833 13.55 69.19 -5.11 unkown ik histidine acid phosphatase domain 21 Hisppd2a Mm.386076 15.18 76.06 -5.01 unkown containing 2A 9430027B09Ri 22 RIKEN cDNA 9430027B09 gene --- 12.59 57.25 -4.55 unkown k platelet-derived growth factor, D regulation of progression 23 Pdgfd Mm.390122 7.89 35.24 -4.47 polypeptide through cell cycle 24 defensin beta 6 Defb6 Mm.358822 14.31 63.42 -4.43 defense response microtubule-associated protein, 25 Mapre1 Mm.143877 28.14 121.24 -4.31 cell cycle RP/EB family, member 1 26 oocyte secreted protein 1 Oosp1 Mm.24754 14.44 55.49 -3.84 unkown 27 microtubule-associated protein 2 Mtap2 Mm.256966 36.88 141.21 -3.83 microtubule bundle formation zinc finger, CCHC domain 28 Zcchc3 Mm.427626 102.36 379.39 -3.71 biological process containing 3 Potassium channel, subfamily T, 29 Kcnt2 Mm.329016 1.81 6.66 -3.69 cell adhesion member 2 30 centrosomal protein 27 Cep27 --- 140.69 512 -3.64 unkown 31 C1q and tumor necrosis factor C1qtnf3 Mm.280158 59.1 214.5 -3.63 biological process related protein 3 CTD (carboxy-terminal domain, 32 RNA polymerase II, polypeptide Ctdspl2 Mm.249405 10.74 37.59 -3.5 biological process A) small phosphatase like 2 transformation related protein 53 regulation of transcription 33 Trp53bp1 Mm.215389 10.05 34.15 -3.4 binding protein 1 transcription 2300002M23R 34 RIKEN cDNA 2300002M23 gene Mm.265291 34.33 112.71 -3.28 unkown ik CEA-related cell adhesion 35 Ceacam10 Mm.30300 13.32 43.56 -3.27 unkown molecule 10 transmembrane emp24 protein 36 Tmed6 Mm.23032 23.28 75.82 -3.26 Transport transport domain containing 6 37 tight junction protein 2 Tjp2 Mm.104744 469.38 1512.45 -3.22 unkown 38 transmembrane protein 27 Tmem27 Mm.143766 15.59 48.93 -3.14 proteolysis cytoskeleton organization and 39 keratin 18 Krt18 Mm.22479 220.94 685.27 -3.1 biogenesis Nuclear receptor subfamily 4, regulation of transcription 40 Nr4a2 Mm.3507 12.26 37.6 -3.07 group A, member 2 transcription solute carrier family 39 (metal ion 41 Slc39a8 Mm.30239 114.2 349.21 -3.06 Transport transporter), member 8 eukaryotic translation elongation 42 Eef1b2 Mm.2718 6637.11 20081.02 -3.03 protein biosynthesis factor 1 beta 2 43 calreticulin 3 Calr3 Mm.196315 48.58 146.31 -3.01 protein folding 2610017I09Ri 44 RIKEN cDNA 2610017I09 gene Mm.45203 37.19 108.98 -2.93 unkown k 45 matrix-remodelling associated 7 Mxra7 Mm.64962 132.37 384.75 -2.91 unkown cell adhesion multicellular organismal 46 EGF-like-domain, multiple 6 Egfl6 Mm.37707 77.67 222.1 -2.86 development cell differnetiation 47 serine incorporator 3 Serinc3 Mm.218473 281.06 778.19 -2.77 induction of apoptosis aldo-keto reductase family 1, 48 Akr1c19 Mm.22832 34.78 95.21 -2.74 biological process member C19 49 centrosomal protein 27 Cep27 Mm.221900 112.73 308.11 -2.73 unkown RNA-dependent DNA 50 gag protein LOC639390 Mm.423255 2111.28 5724.04 -2.71 replication 3300001M20R regulation of translational 51 RIKEN cDNA 3300001M20 gene Mm.34199 60.23 163.15 -2.71 ik initiation multicellular organismal NLR family, pyrin domain development 52 Nlrp14 Mm.35644 24.13 64.49 -2.67 containing 14 cell differentiation spermatogenesis 53 prominin 1 Prom1 Mm.6250 224.65 594.13 -2.64 unkown 54 Eph receptor B1 Ephb1 Mm.22897 93.02 244.85 -2.63 protein phosphorylation establishment of cohesion 1 55 Esco1 Mm.210996 39.9 104.06 -2.61 cell cycle homolog 1 (S. cerevisiae) 56 Brevican Bcan Mm.4598 371.44 967.61 -2.61 cell adhesion 57 periostin, osteoblast specific factor Postn Mm.236067 328.17 853.1 -2.6 cell adhesion serine peptidase inhibitor, Kazal 58 Spink10 Mm.312675 20.58 53.44 -2.6 unkown type 10 Ca<2+>dependent activator 59 Cadps Mm.260881 85.37 220.78 -2.59 Transport protein for secretion C330050A14R 60 RIKEN cDNA C330050A14 gene Mm.403158 21.49 55.57 -2.59 unkown ik regulation of transcription 61 paired related 1 Prrx1 Mm.288642 11.7 29.98 -2.56 multicellular organismal development phospholipase A2, activating 62 Plaa Mm.22724 10.45 26.73 -2.56 signal transduction protein Metastasis associated lung 63 adenocarcinoma transcript 1 Malat1 Mm.298256 245.2 624.73 -2.55 unkown (non-coding RNA) regulation of transcription 64 RNA binding motif protein 39 Rbm39 Mm.392436 44.28 112.93 -2.55 transcription 65 autophagy-related 4A (yeast) Atg4a Mm.393320 38.82 98.47 -2.54 proteolysis fatty acid binding protein 4, 66 Fabp4 Mm.582 1963.74 4965.33 -2.53 transport adipocyte 67 olfactomedin-like 3 Olfml3 Mm.211535 110.65 279.15 -2.52 unkown phosphoenolpyruvate 68 Pck1 Mm.266867 125.63 315.08 -2.51 gluconeogenesis carboxykinase 1, cytosolic POU domain, class 3, transcription regulation of transcription, 69 Pou3f3 Mm.121789 38.3 95.42 -2.49 factor 3 DNA-dependent 70 MAM domain containing 2 Mamdc2 Mm.50841 86.53 214.53 -2.48 unkown protein amino acid 71 Protein tyrosine phosphatase 4a2 Ptp4a2 Mm.193688 934.51 2306.15 -2.47 dephosphorylation 72 tripartite motif protein 25 Trim25 Mm.248445 162.4 399.18 -2.46 unkown regulation of transcription, 73 Similar to reduced expression 2 LOC195531 Mm.381368 27.55 66.63 -2.42 DNA-dependent 74 kinesin family member 5B Kif5b Mm.223744 157.3 373.96 -2.38 mitochondrial transport pyridine nucleotide 75 cDNA sequence BC016495 BC016495 Mm.211595 30.95 73.37 -2.37 biosynthesis 76 cDNA sequence BC099439 BC099439 Mm.347543 25.54 60.62 -2.37 protein modification 77 forkhead box O3a Foxo3a Mm.338613 122.25 290.01 -2.37 regulation of transcription 78 pregnancy specific glycoprotein 19 Psg19 Mm.36878 11.54 27.22 -2.36 pregnancy 79 ribosomal protein S19 Rps19 Mm.300281 21.18 49.98 -2.36 protein biosynthesis membrane targeting (tandem) C2 80 Mtac2d1 Mm.390521 29.82 70.11 -2.35 unkown domain containing 1 acyl-Coenzyme A binding domain 81 Acbd7 Mm.99733 90.03 211.62 -2.35 unkown containing 7 2310045A20R 82 RIKEN cDNA 2310045A20 gene Mm.235020 384.98 897.24 -2.33 unkown ik collagen and calcium binding EGF 83 Ccbe1 Mm.207108 35.73 83.31 -2.33 phosphate transport domains 1 regulation of transcription 84 TSC22 domain family, member 1 Tsc22d1 Mm.153272 26.93 62.56 -2.32 transcription processing of precursor 4, 85 ribonuclease P/MRP family, (S. Pop4 Mm.22284 303.8 693.21 -2.28 rRNA processing cerevisiae) calcium/calmodulin-dependent 86 Camk2n1 Mm.41603 258.59 586.49 -2.27 cell adhesion protein kinase II inhibitor 1 receptor (calcitonin) activity 87 Ramp3 Mm.39884 137.76 311.54 -2.26 transport modifying protein 3 DNA segment, Chr 1, ERATO Doi 88 D1Ertd471e Mm.101743 104.55 236.55 -2.26 unkown 471, expressed mitogen activated protein kinase 89 Mapk10 Mm.39253 17.09 38.45 -2.25 protein phosphorylation 10 90 cDNA sequence BC038479 BC038479 Mm.293696 129 290.16 -2.25 metabolic process regulation of transcription, 91 expressed sequence AU041133 AU041133 Mm.111063 28.85 64.79 -2.25 DNA-dependent solute carrier family 40 92 (iron-regulated transporter), Slc40a1 Mm.28756 303.65 680.38 -2.24 Transport member 1 lymphocyte antigen 6 complex, 93 Ly6h Mm.22154 35.1 78.68 -2.24 unkown locus H v-erb-b2 erythroblastic leukemia 94 Erbb3 Mm.373043 86.57 194.02 -2.24 protein phosphorylation viral oncogene homolog 3 (avian) 4933409K07R 95 RIKEN cDNA 4933409K07 gene Mm.418047 15.55 34.87 -2.24 unkown ik 96 autophagy-related 5 (yeast) Atg5 Mm.22264 177.36 394.85 -2.23 autophagic vacuole formation regulation of transcription multicellular organismal 97 zinc finger protein 354A Zfp354a Mm.4792 41.04 91.56 -2.23 development transcription 98 G protein-coupled receptor 64 Gpr64 Mm.213016 157.92 352.78 -2.23 signal transduction 9630031F12Ri 99 RIKEN cDNA 9630031F12 gene Mm.266466 34.48 76.93 -2.23 unkown k zinc finger protein 386 100 Zfp386 Mm.254997 58.63 130.38 -2.22 regulation of transcription (Kruppel-like) 101 cadherin 1 Cdh1 Mm.35605 82.08 182.41 -2.22 cell adhesion 102 COP9 (constitutive Cops2 Mm.3596 670.33 1471.41 -2.2 signal transduction photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) 1110008H02Ri 103 RIKEN cDNA 1110008H02 gene Mm.28311 1766.55 3877.84 -2.2 unkown k 2610044O15R regulation of transcription, 104 RIKEN cDNA 2610044O15 gene Mm.434403 41.61 91.3 -2.19 ik DNA-dependen DEAD (Asp-Glu-Ala-Asp) box 105 Ddx3y Mm.302938 291.35 635.36 -2.18 unkown polypeptide 3, Y-linked 106 matrix-remodelling associated 7 Mxra7 Mm.64962 384.36 836.87 -2.18 unkown neural precursor cell expressed, cell adhesion 107 developmentally down-regulated Nedd9 Mm.288980 20.55 44.69 -2.18 cell cycle gene 9 108 G protein-coupled receptor 23 Gpr23 Mm.90147 24.17 52.43 -2.17 signal transduction hyaluronan and proteoglycan link 109 Hapln1 Mm.266790 17.63 38.22 -2.17 cell adhesion protein 1 110 osteoglycin Ogn Mm.4258 666.19 1440.73 -2.16 unkown 111 zinc finger protein 120 Zfp120 Mm.254018 39.13 83.93 -2.15 biological process D730048I06Ri 112 RIKEN cDNA D730048I06 gene Mm.99495 32.44 69.71 -2.15 unkown k 113 transmembrane protein 87A Tmem87a Mm.260712 670.07 1437.59 -2.15 unkown 5730601F06Ri regulation of transcription, 114 RIKEN cDNA 5730601F06 gene Mm.428682 265.53 569.98 -2.15 k DNA-dependent 115 Tp53rk binding protein Tprkb Mm.218434 49.9 106.56 -2.14 biological process Phosphodiesterase 5A, 116 Pde5a Mm.134911 62.01 132.98 -2.14 signal transduction cGMP-specific 117 phospholipase A2, group IVB Pla2g4b Mm.41467 378.75 805.71 -2.13 phospholipid catabolism (cytosolic) 118 zinc finger protein 142 Zfp142 Mm.207298 29.64 63.17 -2.13 transcription 119 defensin beta 10 Defb10 Mm.220170 19.26 40.92 -2.12 defense response 120 integrator complex subunit 1 Ints1 Mm.292942 138.63 293.76 -2.12 unkown 1700029I01Ri regulation of transcription, 121 RIKEN cDNA 1700029I01 gene Mm.392861 124.27 262.47 -2.11 k DNA-dependent 122 zinc finger protein 68 Zfp68 Mm.27575 109.2 229.84 -2.1 regulation of transcription regulation of transcription, 123 cDNA sequence BC003267 BC003267 Mm.102799 133.41 279.8 -2.1 DNA-dependent regulation of transcription 124 zinc finger protein 467 Zfp467 Mm.2464 46.2 96.43 -2.09 transcription neural precursor cell expressed, cell adhesion 125 developmentally down-regulated Nedd9 Mm.288980 267.43 558.65 -2.09 cell cycle gene 9 regulation of transcription multicellular organismal 126 homeo box A9 Hoxa9 Mm.4694 28.17 58.93 -2.09 development transcription E030004N02R 127 RIKEN cDNA E030004N02 gene Mm.393243 70.23 147 -2.09 unkown ik 128 WAP four-disulfide core domain 2 Wfdc2 Mm.27289 149.72 311.31 -2.08 proteolysis 129 Scm-like with four mbt domains 2 Sfmbt2 Mm.329991 87.75 182.88 -2.08 regulation of transcription 130 nebulin Neb Mm.389247 17.95 37.31 -2.08 phospholipid metabolism ATPase, Na+/K+ transporting, transport 131 Atp1a2 Mm.207432 419.98 872.31 -2.08 alpha 2 polypeptide metabolic process 132 RIKEN cDNA 6330509M05 gene 6330509M05R Mm.392827 13.62 28.03 -2.06 unkown ik 133 Ankyrin 2, brain Ank2 Mm.220242 12.48 25.76 -2.06 apoptosis 134 paternally expressed 3 Peg3 Mm.389800 205.67 420.77 -2.05 apoptosis cysteine rich transmembrane BMP 135 Crim1 Mm.311912 301.18 616.04 -2.05 regulation of cell growth regulator 1 (chordin like) 136 cDNA sequence BC002059 BC002059 Mm.255974 90.18 183.62 -2.04 unkown membrane targeting (tandem) C2 137 Mtac2d1 Mm.390521 54.58 111.54 -2.04 unkown domain containing 1 138 stearoyl-Coenzyme A desaturase 1 Scd1 --- 752.03 1527.19 -2.03 lipid metabolism 139 expressed sequence AI851790 AI851790 Mm.51939 17.24 34.92 -2.03 unkown regulation of transcription 140 zinc finger protein 467 Zfp467 Mm.2464 128.7 260.96 -2.03 transcription 141 zinc finger protein 398 Zfp398 Mm.169059 79.35 161.2 -2.03 regulation of transcription 142 tripartite motif protein 2 Trim2 Mm.44876 88.44 179.91 -2.03 biological process 143 Transcribed locus --- Mm.392968 298.37 606.32 -2.03 unkown retinitis pigmentosa 2 homolog 144 Rp2h Mm.288141 58.68 118.33 -2.02 GTP biosynthesis (human) 145 UBX domain containing 2 Ubxd2 Mm.293321 21.42 43.36 -2.02 unkown 146 osteoglycin Ogn Mm.4258 188.01 376.99 -2.01 unkown 147 complement component factor h Cfh Mm.8655 129.19 259.79 -2.01 immune response 148 cDNA sequence BC005471 BC005471 Mm.306038 103.95 208.86 -2.01 regulation of transcription 149 Ewing's tumor-associated antigen 1 Etaa1 Mm.178684 175.78 354.17 -2.01 unkown