Hindawi Publishing Corporation BioMed Research International Volume 2014, Article ID 543673, 16 pages http://dx.doi.org/10.1155/2014/543673 Research Article Complex Network-Driven View of Genomic Mechanisms Underlying Parkinson’s Disease: Analyses in Dorsal Motor Vagal Nucleus, Locus Coeruleus, and Substantia Nigra Beatriz Raposo Corradini,1 Priscila Iamashita,1 Edilaine Tampellini,2,3 José Marcelo Farfel,3,4 Lea Tenenholz Grinberg,2,5,6 and Carlos Alberto Moreira-Filho1 1 Department of Pediatrics, Faculdade de Medicina da USP (FMUSP), Avenida Dr. Eneas´ Carvalho Aguiar 647, 5 Andar, 05403-900 Sao˜ Paulo, SP, Brazil 2 Brazilian Aging Brain Study Group (BEHEEC), LIM 22, FMUSP, 01246-903 Sao˜ Paulo, SP, Brazil 3 Hospital Israelita Albert Einstein, 05652-900 Sao˜ Paulo, SP, Brazil 4 Division of Geriatrics, FMUSP, 01246-903 Sao˜ Paulo, SP, Brazil 5 Department of Pathology, FMUSP, 01246-903 Sao˜ Paulo, SP, Brazil 6 Department of Neurology and Pathology, University of California, San Francisco, CA 94143, USA Correspondence should be addressed to Carlos Alberto Moreira-Filho;
[email protected] Received 28 May 2014; Accepted 15 September 2014; Published 26 November 2014 Academic Editor: Meike Kasten Copyright © 2014 Beatriz Raposo Corradini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Parkinson’s disease (PD)—classically characterized by severe loss of dopaminergic neurons in the substantia nigra pars compacta— has a caudal-rostral progression, beginning in the dorsal motor vagal nucleus and, in a less extent, in the olfactory system, progressing to the midbrain and eventually to the basal forebrain and the neocortex.