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L CF IUPAB 0617 Programme-29.Indd 19th IUPAB congress and 11th EBSA congress Scientific Programme Scientific programme Sunday 16 July 2017 12:30–14:00 EBSA EC First Meeting (closed) Harris Room 1 13:30–18:00 Registration Atrium 14:30–15:30 PUBLIC LECTURE Chair: Frank Gunn-Moore, University of St Andrews, UK Alzheimer’s Disease: Addressing a Twenty-First Century Plague Christopher M Dobson, University of Cambridge, UK Sponsored by Alzheimer’s Research (UK), Scottish Network Lennox Suite 16:45–17:15 Welcome Address Lennox Suite 17:15–18:00 PLENARY LECTURE Chair: Andrew Turber field, University of Oxford, UK Lennox Suite IUPAB Ramachandran Lecture: The termination of translation in bacteria and eukaryotes Venki Ramakrishnan, LMB Cambridge, UK 18:00–19:30 Welcome Reception (open to all registered delegates) Cromdale and Strathblane Halls Monday 17 July 2017 08:00–18:00 Registration Atrium 09:00–09:45 PLENARY LECTURE Chair: Ilpo Vattulainen, EBSA, University of Helsinki, Finland Lennox Suite Towards a mechanistic understanding of ribosomal function Helmut Grubmüller, Max Planck Institute for Biophysical Chemistry, Germany 09:55–12:40 SO1 – MULTISCALE BIOPHYSICS OF MEMBRANES Chairs: Claudio M Soares and John Seddon Lennox Suite 09:55 (Invited) Mechanisms of Membrane 10:25 (Invited) Structure on the 10:55 Developing ESCRT-III as a toolkit for Curvature Generation nanoscopic scale of complex bottom-up construction of eukaryote-like Tobias Baumgart, University of Pennsylvania, biomembrane mimetics artificial cells USA Georg Pabst, University of Graz, Austria Andrew Booth, University of Leeds, UK 11:10–11:40 Refreshment break Cromdale and Strathblane Halls 11:40 (Invited) Physical model of cellular 12:10 Anomalous diffusion in artificial 12:25 Cholesterol and polyunsaturated organelles biogenesis and transport lipid bilayers lipids working in concert to modulate G Pierre Sens, Institut Curie, France Helena Coker, University of Oxford, UK protein-coupled receptors Ilpo Vattulainen, University of Helsinki, Finland www.iupab2017.org Scientific Programme 19th IUPAB congress and 11th EBSA congress 09:55–12:40 S02 – MOLECULAR MACHINERY Chairs: Rober t Cross and Claudia Veigel Pentland Auditorium 09:55 (Invited) Shape remodeling of active 10:25 (Invited) Engineering controllable 10:55 Structural dynamics of the 70S cytoskeletal vesicles biomolecular motors ribosome during translocation monitored Andreas Bausch, Technical University Zev Bryant, Stanford University, USA by single-molecule FRET Munich, Germany Sarah Adio, MPI biophysical Chemistry, Germany 11:10–11:40 Refreshment break Cromdale and Strathblane Halls 11:40 (Invited) Navigating the 12:10 Stepping motion and chemo- 12:25 Single-molecule dissection of cytoskeleton: using light to dissect and mechanical coupling of chitinase resolved cytoplasmic dynein force sensing direct intracellular transport by single-molecule analysis Arne Gennerich, Albert Einstein College of Lukas Kapitein, Utrecht University, Ryota Iino, National Institutes of Natural Medicine, USA Netherlands Sciences, Japan 09:55–12:40 S03 – QUANTITATIVE APPROACHES TO GENE REGULATION Chairs: Pietro Cicuta and Mike Tyers Lomond Suite 09:55 (Invited) Sequence specificity of 10:25 (Invited) Nutrient dependent levels 10:55 Nucleosome mobility and the unconventional RNA binding proteins of SBF and MBF are key factors controlling regulation of gene expression: insights Tim Hughes, University of Toronto, Canada start in budding yeast from single-molecule studies Cathy Royer, Rensselaer Polytechnic Ariel Kaplan, Technion – Israel Institute of Institute, USA Technology, Israel 11:10–11:40 Refreshment break Cromdale and Strathblane Halls 11:40 (Invited) DNA repair at the single 12:10 Heat triggers specific mRNA 12:25 Beyond sequence: implications of cell level in bacteria localization to regulatory RNA-protein DNA structure and dynamics in genome Meriem El Karoui, University of Edinburgh, granules in budding yeast function UK Edward Wallace, University of Edinburgh, UK Agnes Noy, University of York, UK 09:55–12:40 S04 – SYNTHETIC BIOLOGY Chairs: Justin Gallivan and Petra Oyston Sidlaw Auditorium 09:55 (Invited) Metal nanoparticle 10:25 (Invited) Exploiting nano- and 10:55 Artificial cell reactor array biosynthesis macroscale insights into water-repellent technology Louise Horsfall, University of Edinburgh, UK microbes and soil for anticorrosion Hiroyuki Noji, The University of Tokyo, Japan Geer tje van Keulen, Swansea University, UK 11:10–11:40 Refreshment break Cromdale and Strathblane Halls 11:40 (Invited) Programmable on-chip 12:10 Bioinspired sensor material 12:25 The development of hybrid DNA compartments as ‘artificial cells’ for broad-banded molecular scale, biomaterials for regenerative engineering Roy Bar-Ziv, Weizmann Institute of Science, wavelength selective detection Adam Perriman, University of Bristol, UK Israel Javier Vinals, University of Oxford, UK www.iupab2017.org 19th IUPAB congress and 11th EBSA congress Scientific Programme 09:55–12:40 S05 – PROTEIN-NUCLEIC ACID INTERACTIONS Chairs: Brian Smith and Maria Spies Fintry Auditorium 09:55 (Invited) Direct visualization of 10:25 (Invited) Single-molecule insight 10:55 Real-time investigation of the ParB-DNA interactions using combined into target recognition by CRISPR-Cas assembly dynamics of artificial virus-like Magnetic Tweezers and TIRF microscopy enzymes particles Fernando Moreno-Herrero, Centro Nacional Ralf Seidel, Leipzig University, Germany Margherita Marchetti, Vrije Universiteit de Biotecnologia, Spain Amsterdam, Netherlands 11:10–11:40 Refreshment break Cromdale and Strathblane Halls 11:40 (Invited) Structural insights into 12:10 NMR reveals how phosphorylation 12:25 Structural information of PTBP1/ Endonuclease G in regulating life and of the retinoic acid nuclear receptor EMCV complex by combining orthogonal death of a cell regulates gene expression spin labelling with pulse EPR Hanna Yuan, Academia Sinica, Taiwan Bruno Kieffer, IGBMC, France Christoph Gmeiner, ETH Zurich, Switzerland 12:40–14:40 Poster Session 1, lunch and exhibits Cromdale and Strathblane Halls 12:40–14:40 HFSP Support for Biophysicists (open to all) Fintry Auditorium 12:40–13:40 Japan Bid Presentation Ochil Room 13:00–14:00 Physics of Life Steering Group meeting (closed) Carrick Room 2 13:00–14:30 EBSA National Societies’ Presidents meeting (by invitation only) Menteith 13:30–14:40 Biophysical Reviews, Springer-Nature Editorial Board Meeting Harris Room 2 14:40–15:25 PLENARY LECTURE Chair: Zihe Rao, President IUPAB, Beijing, China Lennox Suite Bei Lecture: Single cell genomics: stochasticity meets precision in biology and medicine Xiaoliang Sunney Xie, Harvard University, USA 15:25–15:50 EBSA Young Investigator Award 2017 Chair: Manuel Prieto, Past President, EBSA, University of Lisbon, Portugal Towards mass spectrometry of single molecules with light Philipp Kukura, University of Oxford, UK Lennox Suite 16:00–18:00 IUPAB Council meeting (closed) Harris Room 2 16:00–18:45 S06 – PROTEIN STRUCTURE TO FUNCTION Chairs: Jacqueline Cherfils and Malcolm Walkinshaw Lennox Suite 16:00 (Invited) Dynamic complexes and 16:30 (Invited) MicroED opens a new era 17:00 Observation of water-channel complex dynamics: from fundamental for biological structure determination opening of cytochrome c oxidase by time- biophysics to physiological function Tamir Gonen, Howard Hughes Medical resolved XFEL crystallography Martin Blackledge, Institut de Biologie Institute, USA Minoru Kubo, RIKEN, Japan Structurale Grenoble, France 17:15–17:45 Refreshment break Cromdale and Strathblane Halls 17:45 (Invited) The structure of the 18:15 Bacterial surface-layer-protein 18:30 A tri-ubiquitin bridges two ABIN2 nuclear pore complex assemblies at atomic scale dimers to form a higher-order signaling André Hoelz, California Institute of Tea Pavkov-Keller, University of Graz, Austria complex Technology, USA Yu-Chih Lo, National Cheng Kung University, Taiwan www.iupab2017.org Scientific Programme 19th IUPAB congress and 11th EBSA congress 16:00–18:45 S07 – NANOBIOPHYSICS Chairs: Hagan Bayley and Jesús Pérez-Gil Pentland Auditorium 16:00 (Invited) Linking mechanochemistry 16:30 (Invited) Single-molecule label-free 17:00 Using AFM to study red blood cells’ with protein folding with single bond analysis of sequence specific protein-DNA morphology and elasticity on Amyotrophic resolution interactions Lateral Sclerosis Sergi Garcia-Manyes, King’s College London, David Rodriguez-Larrea, University of the Catarina Sousa Lopes, Instituto de Medicina UK Basque Country, Spain Molecular, Portugal 17:15–17:45 Refreshment break Cromdale and Strathblane Halls 17:45 (Invited) Ion channels and porins 18:15 Probing early virus binding steps 18:30 The mechanical properties of made from DNA towards living cells using force-distance HIV-1 capsid during reverse transcription: Ulrich Keyser, University of Cambridge, UK curve-based AFM insights into uncoating Melanie Koehler, Université Catholique de Itay Rousso, University of the Negev, Israel Louvain, Belgium 16:00–18:45 S08 – FORCES IN AND BETWEEN CELLS: FILAMENTS, MEMBRANES AND WALLS Chairs: Jamie Hobbs and Michael Sheetz Lomond Suite 16:00 (Invited) Mechano-devo: how 16:30 (Invited) Sensing matrix rigidity: 17:30 Correlative AFM and cryo-EM growth and form derived mechanical transducing mechanical signals from approach for probing the nuclear lamina forces channel morphogenesis integrins to the nucleus mechanics Olivier Hamant, École Normale Supérieure Pere Roca-Cusachs Soulere, Universitat de Tanuj Sapra, University
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