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March 2019 Volume 90 Issue 3 90 Impact 3 Factor 7.144 Volume 90 Issue 3 Contents Volume 90 Issue 3 | JNNP March 2019 Pages 247–368 JOURNAL OF NEUROSURGERY & PSYCHIATRY

Editorial commentaries Neuromuscular J Neurol Neurosurg Psychiatry: first published as on 1 March 2019. Downloaded from

ISSUE HIGHLIGHTS 247 The unintended consequences of NICE 294 Neurochemical correlates of functional decline

Epilepsy – at it’s best Amyotrophic Lateral Sclerosis – Age of onset G Giovannoni – 10 years of risk sharing in amyotrophic lateral sclerosis – Endovascular therapy outcomes Neuropathy – Mining the PTSD – Therapy for Veterans I Cheong, D K Deelchand, L E Eberly, M Marja ska, G Manousakis, G Guliani, D Walk, March 2019 249 surgery at its best: randomised ń jnnp.bmj.com prospective controlled trials in neurosurgery G Öz Cover image: tree. are no magic Editor P C Warnke Cognitive neurology Matthew C Kiernan (Australia) 302 Brain mechanisms underlying apathy Deputy Editors C Le Heron, C B Holroyd, J Salamone, M Husain Karen L Furie (USA) 250 What does age at onset in ALS tell us about Satoshi Kuwabara (Japan) the genetic basis of the ? Lawrence Wong (China) J H Veldink Associate Editors Cerebrovascular disease Alan Carson (UK) 313 Impact of infarct location on functional Nick Ward (UK) Multiple sclerosis outcome following endovascular therapy for Peter Warnke (USA) 251 Assessing the long-term effectiveness of Commissioning Editor stroke Martin Turner (UK) interferon-beta and glatiramer acetate in C Rosso, R Blanc, J Ly, Y Samson, S Lehéricy, Web Editors multiple sclerosis: final 10-year results from B Gory, G Marnat, M Mazighi, A Consoli, Clare Caldwell the UK multiple sclerosis risk-sharing scheme J Labreuche, S Saleme, V Costalat, S Bracard, Arun Krishnan J Palace, M Duddy, M Lawton, T Bregenzer, F Zhu, H Desal, M Piotin, B Lapergue, on behalf of the Cindy Lin ASTER Trial and Pitié-Salpêtrière Investigators Steve Vucic M Boggild, B Piske, N P Robertson, J Oger, Podcast Editor H Tremlett, K Tilling, Y Ben-Shlomo, R Lilford, Elizabeth Highton-Williamson C Dobson 320 Early versus late anticoagulation for ischaemic JNNP Blog Editors stroke associated with : Jose Manuel Matamala Thanuja Dharmadasa 261 Early diagnosis of progressive multifocal multicentre cohort study JNNP Facebook Editors leucoencephalopathy: longitudinal lesion D Wilson, G Ambler, G Banerjee, C Shakeshaft, Cindy Lin evolution H Cohen, T A Yousry, R Al-Shahi Salman, William Huynh C Scarpazza, A Signori, L Prosperini, M P Sormani, G Y H Lip, H Houlden, M M Brown, K W Muir, Editors, Practical Neurology H R Jäger, D J Werring, on behalf of the Clinical Geraint Fuller (UK) M Cosottini, R Capra, S Gerevini, for the Italian PML Group relevance of Microbleeds in Stroke (CROMIS-2) Phil Smith (UK) collaborators Editorial Office Journal of Neurology Neurosurgery & http://jnnp.bmj.com/ Psychiatry BMJ Publishing Group Ltd 268 Younger age of onset in familial amyotrophic BMA House Tavistock Square lateral sclerosis is a result of pathogenic London WC1H 9JR, UK variants, rather than ascertainment bias E: [email protected] P R Mehta, A R Jones, S Opie-Martin, A Shatunov, Twitter: @JNNP_BMJ A Iacoangeli, A Al Khleifat, B N Smith, S Topp, ISSN: 0022-3050 (print) MORE CONTENTS K E Morrison, P J Shaw, C E Shaw, S Morgan, on September 25, 2021 by guest. Protected copyright. ISSN: 1468-330X (online) Impact factor: 7.144 A Pittman, A Al-Chalabi

Disclaimer: JNNP is published by BMJ Publishing This article has been chosen by the Editor to be of special interest­ Group Ltd, a wholly owned subsidiary of the British 272 Platelet abnormalities in Huntington’s disease or importance and is freely available online. Medical Association. The BMJ Group grants editorial freedom to the Editor of JNNP. JNNP follows H L Denis, J Lamontagne-Proulx, I St-Amour, This article has been chosen in conjunction with the BMJ Patient guidelines on editorial independence produced by S L Mason, J W Rowley, N Cloutier, M-È Tremblay, the World Association of Medical Editors and the Forum to be of particular interest to patients and is freely available code on good publication practice of the Committee A T Vincent, P V Gould, S Chouinard, A S Weyrich, online. on Publication Ethics. M T Rondina, R A Barker, E Boilard, F Cicchetti JNNP is intended for medical professionals and is This article has been made freely available online under the provided without warranty, express or implied. Statements in the journal are the responsibility of BMJ Journals open access scheme. their authors and advertisers and not authors’ 284 Retrotransposons in the development and See http://authors.bmj.com/open-access/ institutions, the BMJ Publishing Group or the BMA unless otherwise specified or determined by law. progression of amyotrophic lateral sclerosis Acceptance of advertising does not imply The article is part of the Impact Commentaries series endorsement. A L Savage, G G Schumann, G Breen, V J Bubb, To the fullest extent permitted by law, the BMJ A Al-Chalabi, J P Quinn Publishing Group shall not be liable for any loss, injury or damage resulting from the use of JNNP or any COPE information in it whether based on contract, tort or otherwise. Readers are advised to verify any information they choose to rely on. Member since 2008 JM00017JM00010 Copyright: © 2019 BMJ Publishing Group. All This journal is a member of and subscribes to the principles of the rights reserved; no part of this publication may be reproduced, stored in a retrieval system, or Committee on Publication Ethics transmitted in any form or by any means, electronic, http://publicationethics.org/ mechanical, photocopying, recording, or otherwise without prior permission. JNNP is published by BMJ Publishing Group Ltd, typeset by Exeter Premedia Services Private Ltd, Chennai, India and printed in the UK on acid-free paper from sustainable forests. Journal of Neurology Neurosurgery & Psychiatry (ISSN No: 0022-3050) is published monthly by BMJ Publishing Group and is distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431 POSTMASTER: send address changes to The online version of this article contains multiple choice Journal of Neurology Neurosurgery & Psychiatry, ­questions hosted on BMJ Learning. Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA Contents Volume 90 Issue 3 | JNNP March 2019

General neurology Neurogenetics 326 Disruption of periaqueductal grey-default 342 Yield of peripheral sodium channels gene J Neurol Neurosurg Psychiatry: first published as on 1 March 2019. Downloaded from mode network functional connectivity predicts screening in pure small fibre neuropathy persistent post-traumatic in mild I Eijkenboom, M Sopacua, J G J Hoeijmakers, traumatic brain injury B T A de Greef, P Lindsey, R Almomani, M Marchi, X Niu, L Bai, Y Sun, S Wang, J Cao, C Sun, J Vanoevelen, H J M Smeets, S G Waxman, Z Wang, H Xu, S Gan, G Fan, W Huang, C Gu, G Lauria, I S J Merkies, C G Faber, M M Gerrits B Yin, G Bai, X Xu, M Zhang 353 Effects of onabotulinumtoxinA treatment for Neuropsychiatry chronic migraine on common comorbidities 333 SMART-CPT for veterans with comorbid including depression and anxiety post-traumatic stress disorder and history of A M Blumenfeld, S J Tepper, L D Robbins, traumatic brain injury: a randomised controlled A Manack Adams, D C Buse, A Orejudos, trial S D Silberstein A J Jak, S Jurick, L D Crocker, M Sanderson-Cimino, R Aupperle, C S Rodgers, K R Thomas, B Boyd, S B Norman, A J Lang, PostScript A V Keller, D M Schiehser, E W Twamley 361 Letters

Electronic pages e1 ABN 2019 abstracts http://jnnp.bmj.com/ on September 25, 2021 by guest. Protected copyright.