Cphi & P-MEC China Exhibition List展商名单version版本20180308
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WO 2012/044761 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date _ . 5 April 2012 (05.04.2012) WO 2012/044761 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 47/48 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, PCT/US201 1/053876 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 29 September 201 1 (29.09.201 1) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Langi English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. 12/893,344 29 September 2010 (29.09.2010) US (84) Designated States (unless otherwise indicated, for every (71) Applicant (for all designated States except US): UNI¬ kind of regional protection available): ARIPO (BW, GH, VERSITY OF NORTH CAROLINA AT WILMING¬ GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, TON [US/US]; 601 South College Road, Wilmington, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, NC 28403 (US). -
Galeterone for the Treatment of Castration- Resistant Prostate Cancer Bruce Montgomery1, Mario A
Published OnlineFirst November 2, 2015; DOI: 10.1158/1078-0432.CCR-15-1432 Cancer Therapy: Clinical Clinical Cancer Research Androgen Receptor Modulation Optimized for Response (ARMOR) Phase I and II Studies: Galeterone for the Treatment of Castration- Resistant Prostate Cancer Bruce Montgomery1, Mario A. Eisenberger2, Matthew B. Rettig3, Franklin Chu4, Roberto Pili5, Joseph J. Stephenson6, Nicholas J. Vogelzang7, Alan J. Koletsky8, Luke T. Nordquist9, William J. Edenfield10, Khalid Mamlouk11, Karen J. Ferrante11, and Mary-Ellen Taplin12 Abstract Purpose: Galeterone is a selective, multitargeted agent that Results: In ARMOR1, across all doses, 49.0% (24/49) achieved a inhibits CYP17, antagonizes the androgen receptor (AR), and 30% decline in prostate-specific antigen (PSA; PSA30) and reduces AR expression in prostate cancer cells by causing an 22.4% (11/49) demonstrated a 50% PSA decline (PSA50). In increase in AR protein degradation. These open-label phase I ARMOR2 part 1, across all doses, PSA30 was 64.0% (16/25) and and II studies [Androgen Receptor Modulation Optimized PSA50 was 48.0% (12/25). In the 2,550-mg dose cohort, PSA30 for Response-1 (ARMOR1) and ARMOR2 part 1] evaluated was 72.7% (8/11) and PSA50 was 54.5% (6/11). Galeterone was the efficacy and safety of galeterone in patients with treat- well tolerated; the most common adverse events were fatigue, ment-naive nonmetastatic or metastatic castration-resistant increased liver enzymes, gastrointestinal events, and pruritus. Most prostate cancer (CRPC) and established a dose for further were mild or moderate in severity and required no action and there study. were no apparent mineralocorticoid excess (AME) events. -
Companion Plants for Better Yields
Companion Plants for Better Yields PLANT COMPATIBLE INCOMPATIBLE Angelica Dill Anise Coriander Carrot Black Walnut Tree, Apple Hawthorn Basil, Carrot, Parsley, Asparagus Tomato Azalea Black Walnut Tree Barberry Rye Barley Lettuce Beans, Broccoli, Brussels Sprouts, Cabbage, Basil Cauliflower, Collard, Kale, Rue Marigold, Pepper, Tomato Borage, Broccoli, Cabbage, Carrot, Celery, Chinese Cabbage, Corn, Collard, Cucumber, Eggplant, Irish Potato, Beet, Chive, Garlic, Onion, Beans, Bush Larkspur, Lettuce, Pepper Marigold, Mint, Pea, Radish, Rosemary, Savory, Strawberry, Sunflower, Tansy Basil, Borage, Broccoli, Carrot, Chinese Cabbage, Corn, Collard, Cucumber, Eggplant, Beet, Garlic, Onion, Beans, Pole Lettuce, Marigold, Mint, Kohlrabi Pea, Radish, Rosemary, Savory, Strawberry, Sunflower, Tansy Bush Beans, Cabbage, Beets Delphinium, Onion, Pole Beans Larkspur, Lettuce, Sage PLANT COMPATIBLE INCOMPATIBLE Beans, Squash, Borage Strawberry, Tomato Blackberry Tansy Basil, Beans, Cucumber, Dill, Garlic, Hyssop, Lettuce, Marigold, Mint, Broccoli Nasturtium, Onion, Grapes, Lettuce, Rue Potato, Radish, Rosemary, Sage, Thyme, Tomato Basil, Beans, Dill, Garlic, Hyssop, Lettuce, Mint, Brussels Sprouts Grapes, Rue Onion, Rosemary, Sage, Thyme Basil, Beets, Bush Beans, Chamomile, Celery, Chard, Dill, Garlic, Grapes, Hyssop, Larkspur, Lettuce, Cabbage Grapes, Rue Marigold, Mint, Nasturtium, Onion, Rosemary, Rue, Sage, Southernwood, Spinach, Thyme, Tomato Plant throughout garden Caraway Carrot, Dill to loosen soil Beans, Chive, Delphinium, Pea, Larkspur, Lettuce, -
Tanibirumab (CUI C3490677) Add to Cart
5/17/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Suggest changes to this concept Tanibirumab (CUI C3490677) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C3490677 NCI Thesaurus Code: C102877 (see NCI Thesaurus info) Semantic Type: Immunologic Factor Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Pharmacologic Substance NCIt Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. PDQ Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor -
Download Product Insert (PDF)
Product Information Galeterone Item No. 17586 N CAS Registry No.: 851983-85-2 Formal Name: 17-(1H-benzimidazol-1-yl)-androsta- 5,16-dien-3β-ol N Synonym: TOK-001 MF: C26H32N2O FW: 388.6 H Purity: ≥98% H H Stability: ≥2 years at -20°C Supplied as: A crystalline solid HO Laboratory Procedures For long term storage, we suggest that galeterone be stored as supplied at -20°C. It should be stable for at least two years. Galeterone is supplied as a crystalline solid. A stock solution may be made by dissolving the galeterone in the solvent of choice. Galeterone is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of galeterone in ethanol and DMSO is approximately 20 mg/ml and approximately 30 mg/ml in DMF. Galeterone is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, galeterone should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Galeterone has a solubility of approximately 0.2 mg/ml in a 1:3 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day. The cytochrome P450 (CYP) isoform CYP17 is also known as steroid 17α-hydroxylase/17,20 lyase because it catalyzes both 17α-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, 1 and mineralocorticoids. Galeterone is a CYP17 inhibitor (IC50 = 300 nM) that has been shown to competitively block synthetic androgen binding (EC50 = 845 nM) and to antagonize the androgen receptor in transcriptional activation 2 assays. -
Chapter 1 Definitions and Classifications for Fruit and Vegetables
Chapter 1 Definitions and classifications for fruit and vegetables In the broadest sense, the botani- Botanical and culinary cal term vegetable refers to any plant, definitions edible or not, including trees, bushes, vines and vascular plants, and Botanical definitions distinguishes plant material from ani- Broadly, the botanical term fruit refers mal material and from inorganic to the mature ovary of a plant, matter. There are two slightly different including its seeds, covering and botanical definitions for the term any closely connected tissue, without vegetable as it relates to food. any consideration of whether these According to one, a vegetable is a are edible. As related to food, the plant cultivated for its edible part(s); IT botanical term fruit refers to the edible M according to the other, a vegetable is part of a plant that consists of the the edible part(s) of a plant, such as seeds and surrounding tissues. This the stems and stalk (celery), root includes fleshy fruits (such as blue- (carrot), tuber (potato), bulb (onion), berries, cantaloupe, poach, pumpkin, leaves (spinach, lettuce), flower (globe tomato) and dry fruits, where the artichoke), fruit (apple, cucumber, ripened ovary wall becomes papery, pumpkin, strawberries, tomato) or leathery, or woody as with cereal seeds (beans, peas). The latter grains, pulses (mature beans and definition includes fruits as a subset of peas) and nuts. vegetables. Definition of fruit and vegetables applicable in epidemiological studies, Fruit and vegetables Edible plant foods excluding -
Therapies Targeted to Androgen Receptor Signaling Axis in Prostate Cancer: Progress, Challenges, and Hope
cancers Review Therapies Targeted to Androgen Receptor Signaling Axis in Prostate Cancer: Progress, Challenges, and Hope Sirin Saranyutanon 1,2, Sanjeev Kumar Srivastava 1,2,*, Sachin Pai 3, Seema Singh 1,2,4 and Ajay Pratap Singh 1,2,4,* 1 Department of Pathology, College of Medicine, University of South Alabama, Mobile, AL 36617, USA; [email protected] (S.S.); [email protected] (S.S.) 2 Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA 3 Department of Medical Oncology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA; [email protected] 4 Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA * Correspondence: [email protected] (S.K.S.); [email protected] (A.P.S.); Tel.: +1-251-445-9874 (S.K.S.); +1-251-445-9843 (A.P.S.) Received: 4 November 2019; Accepted: 18 December 2019; Published: 23 December 2019 Abstract: Prostate cancer is the mostly commonly diagnosed non-cutaneous malignancy and the second leading cause of cancer-related death affecting men in the United States. Moreover, it disproportionately affects the men of African origin, who exhibit significantly greater incidence and mortality as compared to the men of European origin. Since androgens play an important role in the growth of normal prostate and prostate tumors, targeting of androgen signaling has remained a mainstay for the treatment of aggressive prostate cancer. Over the years, multiple approaches have been evaluated to effectively target the androgen signaling pathway that include direct targeting of the androgens, androgen receptor (AR), AR co-regulators or other alternate mechanisms that impact the outcome of androgen signaling. -
Development of Combination Therapy for Prostate Cancer
DEVELOPMENT OF COMBINATION THERAPY FOR PROSTATE CANCER A Dissertation Presented to the Faculty of the Weill Cornell Graduate School of Medical Sciences in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy by Alexander R. Root July 2017 © 2017 Weill Cornell Graduate School of Medical Sciences ALL RIGHTS RESERVED DEVELOPMENT OF COMBINATION THERAPY FOR PROSTATE CANCER Alexander R. Root, Ph.D. Cornell University 2017 There is an unmet need in prostate cancer for effective therapies to prevent the emergence of resistance. Combinations of small molecules targeting key pathways are a promising strategy. I investigated how populations of the early metastatic prostate cancer cell line LNCaP respond at the proteomic and pheno- typic levels to six clinically-relevant, one-drug treatments and their 15 pairs of two-drug combinations, administered simultaneously to treatment-naive cells. After 24 hours of drug addition for all 21 drug treatments I measured 52 total- proteins by selected-reaction monitoring mass-spectrometry based proteomics (SRM), 20 phospho-proteins, and 50 total-proteins by reverse-phase protein ar- rays (RPPA). I measured phenotypic effects on cell proliferation and apoptosis in all conditions using phase-contrast and fluorescence microscopy. Network analysis identified (phospho)-proteins with large responses to drug treatments that are druggable with FDA-approved drugs or have nearest-neighbors that are druggable. A total of ten drugs targeting these nearest responder (phospho)-proteins were tested in single, double, and triple combinations. I found that 7 out of 10 triple combinations co-targeting androgen receptor and PI3K pathways were no more effective than the two-drug combination at the doses tested: PRKC (en- zastaurin), MAPK (losmapimod), STAT3 (napabucasin), HDAC (panobinostat), SRC (saracatinib), casein kinase (silmitasertib), MAPK (ulixertinib). -
Radish CSA Week 24 Oct
Weekly Newsletter This week we are honoring: Radish CSA Week 24 Oct. 22– Oct. 28, 2012 CONTENT 1. It’s time to order fresh turkey! "Eating pungent 2. Come to The Inn at East Lynn! radish and drinking 3. Radish Greens Soup hot tea, let the 4. Mango and Radish Salad with starved doctors beg Lime Dressing on their knees”. 5. Buttery Shrimp and Radish Pasta -Chinese proverb- 6. Radish inspired Sandwiches 7. Nutritional Benefits & Usage If you have any questions or requests, please contact us: [email protected]| (202) 253-3737 | www.eastlynnfarm.com It’s Time to Order Your Fresh Turkey! We are taking orders for FRESH THANKSGIVING TURKEYS. These turkeys are raised on pasture, outdoors and allowed to BE ACTIVE AND HEALTHY, so the birds are stronger and have MORE TEXTURED, DELICIOUS MEAT. THE DEADLINE for ordering Turkeys is November 15, 2012, but don’t wait. Our Turkeys are LIMITED and we expect that our supply will end before this date. The cost per turkey is $135*. The Turkeys weight between 16-18 lbs and SERVE 16-18 ADULTS. If you have any questions, please do not hesitate to contact us at: [email protected] * for CSA members only Come and Enjoy The Inn at East Lynn! THE INN AT EAST LYNN is a historic property (circa 1860) on 143 rolling acres nestled between the beautiful Bull Run and Blue Ridge mountains with breathtaking views of the fall in all of its glorious colors. Only 90 minutes from downtown DC and about 50 minutes from Dulles Int’l Airport, it offers a unique venue for those who cherish an ELEGANT AND STILL BUCOLIC country setting. -
( 12 ) United States Patent
US010314797B2 (12 ) United States Patent ( 10 ) Patent No. : US 10 , 314 ,797 B2 Narayanan et al. ( 45 ) Date of Patent : * Jun . 11, 2019 ( 54 ) SELECTIVE ANDROGEN RECEPTOR ( 56 ) References Cited DEGRADER (SARD ) LIGANDS AND METHODS OF USE THEREOF U . S . PATENT DOCUMENTS 5 ,480 ,656 A 1 / 1996 Okada et al . (71 ) Applicant: University of Tennessee Research 5 ,575 , 987 A 11/ 1996 Kamei et al . Foundation , Knoxville , TN (US ) 5 ,631 , 020 A 5 / 1997 Okada et al. 5 , 643 ,607 A 7 / 1997 Okada et al. 5 ,716 ,640 A 2 / 1998 Kamei et al. ( 72 ) Inventors : Ramesh Narayanan , Cordova , TN 5 , 814 ,342 A 9 / 1998 Okada et al . (US ) ; Duane D . Miller , Collierville , 6 ,036 , 976 A 3 / 2000 Takechi et al . TN (US ) ; Thamarai Ponnusamy , 7 , 118 , 552 B2 10 / 2006 Shaw et al . Memphis , TN (US ); Dong - Jin Hwang, 7 , 220 , 247 B25 / 2007 Shaw et al . 7 ,500 , 964 B23 / 2009 Shaw et al . Arlington , TN (US ) ; Yali He, 9 ,815 , 776 B2 * 11 / 2017 Narayanan . .. .. C07C 255 /60 Germantown , TN (US ) 9 , 834 , 507 B2 * 12 / 2017 Narayanan . .. .. .. C07C 255 /60 2005 /0101657 A1 5 /2005 Furuya et al . (73 ) Assignee : University of Tennessee Research 2007 /0265290 A1 11/ 2007 Dalton et al . 2010 /0227846 AL 9 /2010 Ito et al. Foundation , Knoxville , TN ( US ) 2014 / 0018433 A11 / 2014 Dalton et al . ( * ) Notice : Subject to any disclaimer , the term of this 2018 /0118663 A1 * 5 / 2018 Narayanan . C07C 237/ 20 patent is extended or adjusted under 35 FOREIGN PATENT DOCUMENTS U . S . -
Radish Salad with Orange-Ginger Vinaigrette Ingredients
Radish Salad with Orange-Ginger Vinaigrette Ingredients: 1/2 cup orange juice 2 Tbsp cider vinegar 2 Tbsp minced ginger 1 thinly sliced green onion with green parts 1 tsp salt and sugar or honey 1/2 cup oil 2 cups sliced radishes Preparation: Mix together until blended—extra dressing can be stored in refrigerator for about month Use about a 1/4 of vinaigrette with the two cups of radishes—it just makes a great, crunchy salad! Spring Spinach Dip Ingredients: 1 10-oz box chopped spinach, drained and pressed—you can use fresh chopped spinach, but it takes much more to achieve 1 cup after it has been chopped and pressed 1/2 tsp each of onion and garlic powder 1 tsp salt 1 16-oz sour cream 1 tbsp minced onion 1/2 cup mayo—or use one mashed avocado for a totally different flavor Preparation: Mix together and let set about 1 hour; serve with your favorite chips, crackers, or veggies. Spring Veggie Frittata Ingredients: 4 Tbsp each olive oil and butter 1 cup sliced ramps or green onions 1 cup thinly sliced asparagus 4 cups chopped fresh spinach and Swiss chard 10 eggs, scrambled 1 cup cubed provolone 1/4 cup feta crumbles Salt and pepper to taste Preparation: In a 10” oven-safe skillet, sauté ramps or green onions and asparagus in oil and butter. Add greens. When they are cooked through, add eggs and cheese. Mix everything together and bake in a 325F oven for 20-30 minutes or until done. Serves 4 to 6 people. -
PUTTANESCA CROSTINI Olive Tapenade, Marinated Mussels, Smoked Trout Roe, Pancetta Vinaigrette 11
items to be shared by the table SEAFOOD FRITTO MISTO 14 PORK MEATBALLS 12 ARANCINI 11 arugula, lemon tomato, fig mostarda smoked caciocavallo, sicilian pesto CURED SALUMI PLATTER 16 CHEESE PLATTER 15 LA QUERCIA PROSCIUTTO 12 pickles, mustard mostarda, condimenti white wine braised fennel, capers, grapes PUTTANESCA CROSTINI olive tapenade, marinated mussels, smoked trout roe, pancetta vinaigrette 11 FARM EGG** polenta, foraged mushroom 10 RED LEAF SALAD ricotta, cherry, pepperoncini, shallot, balsamic vinaigrette (great with protein) 10 WARM MOZZARELLA pistachio mascarpone, italian herbs, apple 12 CHICORY SALAD carrot sott'olio, radish, almond, ricotta salata 12 PAPPARDELLE sage, garlic, king trumpet mushroom, pecorino 18 RICOTTA RAVIOLI roasted beets, walnut, brown butter, sage, pecorino 17 BUCATINI AMATRICIANA pomodoro, calabrese chili, guanciale, pecorino 17 MEZZALUNA texas lamb, asparagus, spring onion caponata, parmesan brodo, pecorino 18 LINGUINE NERO rock shrimp, calamari, red onion, arugula, breadcrumbs 19 GREEN GARLIC RISOTTO green garlic, cherry tomato, radish, parmesan 16 TEXAS NEW YORK STRIP grilled broccoli, fingerling potato, celery, spiced cracker 36 SEARED BRANZINO texas field peas, smoked pork belly, hazelnut, sweet potato agrodolce 27 LAMB BOMBA grilled escarole, green chickpea, pickled mustard seed, olive 27 CHARRED SWEET POTATO toasted walnuts, texas goat cheese, african blue basil, smoked balsamic 8 ROASTED BRUSSELS olive tapenade, pecorino 9 TEMPURA SPRING ONION balsamic coriander agrodolce, onion top aioli 9 **There is a risk associated with consuming raw animal protein. If you have a chronic illness of the liver, stomach or blood or have immune disorder, you are at greatest risk of illness from meat. Parties of 6 or more will have a suggested gratuity of 18% indicated on their bill.