(Trenbolone Acetate and Estradiol Benzoate Extended-Release

Exp. Date: Exp.

Lot: Lot: FPO: UPC FPO:

NO ® Glue COPY SYNOVEX Applicators Spot

STEP 1 Loading The Applicator STEP 2 Restraint Load the applicator following The animal must be the directions outlined in confined in a restraint the instruction manual mechanism (squeeze accompanying each applicator. chute or head gate). The When using metal revolver style implant site on the back (trenbolone acetate and estradiol benzoate extended-release implants) applicator, use orange adapter of the ear should be (trenbolone acetate and estradiol benzoate extended-release implants) kit. prepared by scrubbing with a firm bristled brush 200 mg trenbolone acetate and 28 mg estradiol benzoate per implant 200 mg trenbolone acetate and 28 mg estradiol benzoate per implant Additional information that has been soaked in a for the individual germicidal solution. applicator user guides Note: If implanting horned ® can be found at: cattle, greater safety is SYNOVEX SX10 provided when the head is SUBCUTANEOUS IMPLANTS FOR STEERS AND HEIFERS FED IN CONFINEMENT FOR SLAUGHTER SUBCUTANEOUS IMPLANTS FOR STEERS AND HEIFERS FED IN CONFINEMENT FOR SLAUGHTER www.growwithsynovex.com. controlled by the use of a bull lead (nose tongs). NOT FOR USE IN HUMANS. Not for use in dairy or beef Restricted Drug (California)— SYNOVEX ONE Feedlot (trenbolone acetate and NOT FOR USE IN HUMANS. replacement heifers. Use Only As Directed. (trenbolone acetate and estradiol benzoate extended-release implants) FOR ANIMAL USE ONLY. estradiol benzoate extended-release implants) FOR ANIMAL USE ONLY. NET CONTENTS: One pouch contains IMPORTANT: is a growth promoting implant containing 200 mg INDICATIONS FOR USE: For ten 10-dose cartridges (100 implants). Read ALL sides of carton ANIMAL SAFETY WARNING: Bulling, vaginal

Implant Site Insert Needle 200 mg trenbolone acetate and 28 estradiol benzoate per implant STEP 3 STEP 4 increased rate of weight gain and of trenbolone acetate and 28 mg of estradiol and rectal prolapse, udder development, ventral Manufactured By A Approved by FDA under NADA # 141-348 benzoate with a porous polymer film coating that Divide the ear into three Grasp the ear with improved feed efficiency for up to edema and elevated tailheads have occasionally 200 days in steers and heifers fed in Non-Sterilizing Process extends the pay-out period of the final formulation imaginary sections as been reported in heifers administered SYNOVEX ▼ one hand. Holding the Keep this and all drugs out of the reach SYNOVEX® EXACT 10® illustrated. The implanted applicator firmly with the confinement for slaughter. up to 200 days. Each implant consists of 8 pellets. ONE Feedlot implants. pellets should be SUBCUTANEOUS IMPLANTS FOR STEERS AND HEIFERS FED IN CONFINEMENT SLAUGHTER of children. Ten implants are provided in each cartridge. other hand, penetrate the Do not use in veal calves. DIRECTIONS: Implant complete contents of one deposited in the center skin at the point shown by Effectiveness and animal safety in veal NOTE: Studies have demonstrated that the one-third of the ear as cartridge cell per steer or heifer. Approved the “X”. Thrust the needle calves have not been established. administration of SYNOVEX ONE Feedlot can shown. To accomplish under the skin taking implantation technique is fully described in the this, the applicator needle care not to penetrate result in decreased marbling scores when fold-out carton section. should be inserted in the the cartilage. Ease the IMPLANTS FOR STEERS AND HEIFERS FED IN CONFINEMENT SLAUGHTER SUBCUTANEOUS compared to non-implanted steers and heifers. ® NOTE: Never sacrifice careful, clean SYNOVEX Metal Revolver outer one-third of the ear as applicator forward (toward indicated by the “X” in the DOSAGE: One implant (8 pellets), containing technique for speed of implantation. the base of the ear) until 200 mg of trenbolone acetate and 28 mg of illustration. Implanting too the full needle length is STORAGE: Store unopened product at close to the head may beneath the skin. estradiol benzoate, is administered to each steer cause abnormal sexual 200 mg trenbolone acetate and 28 estradiol benzoate per implant or heifer by subcutaneous implantation in the controlled room temperature 20°-25°C behavior. Care should be middle one‑third of the ear. (68° 77°F) with excursions between 15°-30°C

taken to avoid severing the (trenbolone acetate and estradiol benzoate extended-release implants) (59°-86°F). Avoid excessive heat and humidity. (trenbolone acetate and estradiol benzoate extended-release implants) The ten-dose cartridge of SYNOVEX ONE 200 mg trenbolone acetate and 28 mg estradiol benzoate per implant major arteries of the ear. Use product before the expiration date on the Feedlot is designed to be used exclusively with a label. INDICATIONS FOR USE NOT FOR USE IN HUMANS. Synovex applicator. HOW TO IMPLANT Once the pouch is opened, unused product For use with the For increased rate of weight gain and FOR ANIMAL USE ONLY. STEP 5 Pellet Implantation STEP 6 Inspection improved feed efficiency for up to 200 may be stored in the end-folded pouch (away Synovex Applicator days in steers and heifers fed in WITHDRAWAL PERIOD When the needle is Check the implant site. If WITHDRAWAL PERIOD: No from light) for up to six months under refrigerated Study the following instructions confinement for slaughter. No withdrawal period is completely inserted, properly administered, the withdrawal period is required when conditions 2°-8°C

carefully, then proceed step by Do not use in veal calves. Effectiveness required when used activate the instrument by implants should lie in a used according to labeling. (36°-47°F) or at room temperature 20°-25°C directions implanting for here Open step, until the technique and animal safety in veal calves have not according to labeling. squeezing the trigger straight line under the skin. A withdrawal period has not been (68°-77°F) with excursions between 15°-30°C becomes routine. Many head been established. A withdrawal period has not completely. Refer to Re-cock the applicator. (59°-86°F) for up to one month. instructions for individual established for this product in pre- can be implanted per hour by an Not for use in dairy or beef replacement been established for this Disinfect the applicator ▼ heifers. applicator. ruminating calves. Do not use in DISPOSAL: SYNOVEX ONE Feedlot waste experienced team, one member product in pre-ruminating needle in a germicidal STORAGE calves. Do not use in calves solution. The applicator is calves to be processed for veal. materials should be disposed of according to of which should be assigned to Store unopened product at controlled room to be processed for veal. now ready to implant the Implant pellets in ear only. Any other do nothing but the implantation. prescribed Federal, State, and Local guidelines. temperature 20°-25°C (68°-77°F) with Implant pellets in ear only. next animal. location is in violation of Federal law. Care should be taken to insure excursions between 15°-30°C (59°-86°F). Any other location is a viola- Avoid excessive heat and humidity. Do not attempt salvage of implanted the hands of the person tion of Federal law. Do not site for human or animal food. administering the implant are Use product before the expiration date attempt salvage of implanted Distributed by: clean and only sanitary printed on the label. site for human or animal Zoetis Inc. instruments are used. Once the pouch is opened, unused product food. Kalamazoo, MI 49007 40030751 may be stored in the end-folded pouch (away from light) for up to six months under Keep this and all drugs out of the reach of NO refrigerated conditions 2°-8°C (36°-47°F) children. Glue or at room temperature 20°-25°C Restricted Drug (California)— COPY (68°-77°F) with excursions between Use Only as Directed. Spot NET CONTENTS: 10 CARTRIDGES NET CONTENTS: 10 CARTRIDGES 15°-30°C (59°- 86°F) for up to one month. Each Cartridge Contains 10 implants (100 implants total) Each Cartridge Contains 10 implants (100 implants total)

AWC Representative Plant Name / Code Artwork Center: US G. Woods Lincoln/US12 QN / Project No. FG Material No. New Material No. Description 200008606 10014347 40030751 CTN SYNOVEX ONE F IMP 200MGX100 (trenbolone acetate and estradiol benzoate extended-release implants) 200 mg trenbolone acetate and 28 mg estradiol benzoate per implant DIR No. / Version No. Specification / DWG Old Material No. Countries SUBCUTANEOUS IMPLANTS FOR STEERS AND HEIFERS FED IN CONFINEMENT FOR SLAUGHTER 511211 /00 Z14-801390 P04-13797601 US Dimensions Colors 6.75” x 1.9375” x 9” PMS 293 PMS 7413 Dieline Additional Info.

Version No. Date v1 40030751.indd 1 4/2/20 11:12 AM NO ® Glue COPY SYNOVEX Applicators Spot

STEP 3 Implant Site STEP 4 Insert Needle Divide the ear into three Grasp the ear with imaginary sections as one hand. Holding the SYNOVEX® EXACT 10® illustrated. The implanted applicator firmly with the pellets should be other hand, penetrate the deposited in the center skin at the point shown by one-third of the ear as the “X”. Thrust the needle shown. To accomplish under the skin taking this, the applicator needle care not to penetrate should be inserted in the the cartilage. Ease the ® SYNOVEX Metal Revolver outer one-third of the ear as applicator forward (toward indicated by the “X” in the the base of the ear) until illustration. Implanting too the full needle length is close to the head may beneath the skin. cause abnormal sexual behavior. Care should be (trenbolone acetate and estradiol benzoate extended-release implants) taken to avoid severing the 200 mg trenbolone acetate and 28 mg estradiol benzoate per implant major arteries of the ear. HOW TO IMPLANT INDICATIONS FOR USE NOT FOR USE IN HUMANS. For use with the For increased rate of weight gain and FOR ANIMAL USE ONLY. STEP 5 Pellet Implantation STEP 6 Inspection improved feed efficiency for up to 200 Synovex Applicator days in steers and heifers fed in WITHDRAWAL PERIOD When the needle is Check the implant site. If Study the following instructions confinement for slaughter. No withdrawal period is completely inserted, properly administered, the carefully, then proceed step by Do not use in veal calves. Effectiveness required when used activate the instrument by implants should lie in a step, until the technique and animal safety in veal calves have not according to labeling. squeezing the trigger straight line under the skin. becomes rou tine. Many head been established. A withdrawal period has not completely. Refer to Re-cock the applicator. can be implanted per hour by an Not for use in dairy or beef replacement been established for this instructions for individual Disinfect the applicator heifers. product in pre-ruminating applicator. needle in a germicidal ex perienced team, one member STORAGE calves. Do not use in calves solution. The applicator is of which should be assigned to Store unopened product at controlled room to be processed for veal. now ready to implant the do nothing but the implantation. temperature 20°-25°C (68°-77°F) with Implant pellets in ear only. next animal. Care should be taken to insure excursions between 15°-30°C (59°-86°F). Any other location is a viola- the hands of the person Avoid excessive heat and humidity. tion of Federal law. Do not administering the implant are Use product before the expiration date attempt salvage of implanted clean and only sanitary printed on the label. site for human or animal instruments are used. Once the pouch is opened, unused product food. may be stored in the end-folded pouch (away from light) for up to six months under Keep this and all drugs out of the reach of NO refrigerated con di tions 2°-8°C (36°-47°F) children. Glue or at room temperature 20°-25°C Restricted Drug (California)— COPY (68°-77°F) with excursions between Use Only as Directed. Spot 15°-30°C (59°- 86°F) for up to one month.