Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

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Mutagens and Reproductive Toxins H340 H341 H360 H361 H362

This SOP is not a substitute for hands-on training. Print a copy and insert into your laboratory SOP binder. Department: Chemistry

Date SOP was written: Thursday, July 1, 2021 Date SOP was approved by PI/lab supervisor: Thursday, July 1, 2021 Name: F. Fischer Principal Investigator: Signature: ______

Name: Matthew Rollings Internal Lab Safety Coordinator or Lab Manager: Lab Phone: 510.301.1058 Office Phone: 510.643.7205 Name: Felix Fischer Emergency Contact: Phone Number: 510.643.7205 Tan Hall 674, 675, 676, 679, 680, 683, 684 Location(s) covered by this SOP: Hildebrand Hall: D61, D32

1. Purpose This SOP covers the precautions and safe handling procedures for the use of Mutagens and Reproductive Toxins. For a list of Mutagens and Reproductive Toxins covered by this SOP and their use(s), see the “List of Chemicals”. Procedures described in Section 12 apply to all materials covered in this SOP. A change to the “List of Chemicals” does not constitute a change in the SOP requiring review or retraining. If you have questions concerning the applicability of any recommendation or requirement listed in this procedure, contact the Principal Investigator/Laboratory Supervisor or the campus Chemical Hygiene Officer at [email protected].

2. Physical & Chemical Properties/Definition of Chemical Group Germ Cell Mutagenicity is a hazard class that is primarily concerned with chemicals that may cause mutations in the germ cell of humans that can be transmitted to the progeny.

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

A mutation is defined as a permanent change in the amount or structure of genetic material in a cell. Mutagens are agents giving rise to an increased occurrence of mutations in populations of cells and/or organisms. Reproductive toxicity includes adverse effects on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring. These chemicals may present extreme risk potential to laboratory workers if not handled appropriately; therefore, these substances may require additional control measures when used.

3. Potential Hazards/Toxicity

Mutagens and Reproductive Toxins are chemicals that affect the reproductive capabilities including causing chromosomal damage (mutations) and adverse effects on fetal development (teratogenesis). As defined by the Globally Harmonized System of Classification and Labeling of Chemicals (GHS), reproductive toxins are designated by one or more of the following H codes: H340 May cause genetic defects H341 Suspected of causing genetic defects H360 May damage fertility or the unborn child H361 Suspected of damaging fertility or the unborn child H362 May cause harm to breast-fed children Additional requirements may apply, depending on the specific chemical. Examples include particularly hazardous substances that are also highly flammable and/or reactive. Safe use requires assessing all potential hazards. It is the Principal Investigator’s responsibility to ensure activity-specific laboratory procedures and/or processes are taken into account when using this Chemical Class SOP. Please, review the SDS of any chemical before use (see Section 11 – SDS Location).

4. Engineering Controls Use the engineering controls listed below unless other lab-specific information is included in Section 12 - Protocol/Procedure. • Work with mutagens and reproductive toxins – the work must be conducted in a fume hood unless other controls are designated in the lab-specific Protocol/Procedure section. Sash height must be kept as low as possible to avoid escaping fumes and provide a physical barrier. • Laboratories and rooms where Mutagens and Reproductive Toxins are used must have general room ventilation that is negative pressure with respect to the corridors and external environment. The laboratory/room door must be kept closed at all times.

5. Personal Protective Equipment At a minimum, the following PPE must be worn at all times. Eye and Face Protection A. ANSI Z87.1-compliant safety glasses with side shields, or chemical splash goggles.

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

• Ordinary prescription glasses will NOT provide adequate protection unless they also meet ANSI standard and have compliant side shields. B. If the potential for explosion/splashing exists, and adequate coverage is not provided by the hood sash, a face shield must be worn. Skin and Body Protection A. Gloves are required when handling hazardous chemicals. • Refer to specific chemical SDS for information on glove selection. • For additional information on glove selection, go to: http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-and-usage.html B. Lab coats are required when handling hazardous chemicals in the lab. Select the type of lab coat according to the hazards at the specific workplace. C. Long pants, closed-toe/closed-heel shoes, covered legs, and ankles. Respiratory Protection Respiratory protection is normally not required for UC Berkeley laboratory activities. Any lab personnel considering the use of a respirator (e.g. N-95 respirator, dust mask) must contact EH&S for a workplace assessment.

6. First Aid Procedures and Medical Emergencies In the event of an injury, notify your supervisor immediately and EH&S within 8 hours. Go to the Occupational Health Facility (Tang Health Center, on campus); if after hours, go to the nearest emergency room (Alta Bates, 2450 Ashby Ave in Berkeley); or

Call 911 (from a cell phone: 510-642-3333) if: • it is a life threatening emergency; or • you not are confident in your ability to fully assess the conditions of the environment and/or the condition of the contaminated/injured person, or you cannot be assured of your own safety; or • the contaminated/injured person is not breathing or is unconscious. Please remember to provide a copy of the appropriate manufacturer SDS (if available) to the emergency responders or physician. At a minimum, be ready to provide the identity/name of any hazardous materials involved.

In case of skin contact If skin contact occurs, and/or skin or clothing are on fire, immediately drench in the safety shower with copious amounts of water for no less than 15 minutes to remove any remaining contaminants. If possible to do so without further injury, remove any remaining jewelry or clothing. In case of eye contact

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Rinse thoroughly with plenty of water using an eyewash station for at least 15 minutes, occasionally lifting the upper and lower eyelids. Remove contact lenses if possible. If swallowed Do NOT induce vomiting unless directed otherwise by the SDS. Never give anything by mouth to an unconscious person. Rinse mouth with water. If inhaled Move into fresh air. Needle stick/puncture exposure Wash the affected area with antiseptic soap and warm water for 15 minutes.

7. Special Handling, Storage and Disposal Requirements Lab-specific information on handling and storage may be included in Section 12 - Protocol/Procedure.

Precautions for Safe Handling: • Eliminate or substitute for a less hazardous material when possible. • Design your experiment to use the least amount of material possible to achieve the desired result. • Do not exceed the scale of procedures specified in Protocol/Procedure section without approval of the PI. • Verify your experimental set-up and procedure prior to use. • Know the location of the nearest eyewash, safety shower and fire extinguisher before beginning work. • Upon leaving the work area, remove any personal protective equipment worn and wash hands. • At the end of each project, thoroughly decontaminate the work area according to the material being handled.

Conditions for Safe Storage • Store non-flammable mutagens and reproductive toxins within secondary containment. • Chemicals that require refrigeration must be stored appropriately. • Store flammable mutagens and reproductive toxins within flammable storage cabinet. Disposal ● Waste materials generated must be treated as a hazardous waste. ● The empty container must be rinsed three times with a COMPATIBLE solvent; leave it open in the back of the hood overnight. Solvent rinses and water rinse must be disposed of as hazardous waste. ● As an alternative, unrinsed empty containers can be disposed of through EH&S as hazardous waste. The unrinsed empty containers must be capped. ● Do not mix with incompatible waste streams.

8. Chemical Spill Spill – Assess the extent of danger; if necessary request help by calling 911 (from a cell phone: 510-642- 3333) for emergency assistance or 510-642-3073 for non-life threatening situations. If you cannot assess

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

the conditions of the environment well enough to be sure of your own safety, do not enter the area. If possible help contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors from spill. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area. • Minor Spill – In the event of a minor spill, if there is no potential for hazardous chemical exposure, report the spill to 510-642-3073 and proceed to clean it, if you are trained. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and request pick-up. • Major Spill – Any hazardous chemical spill that involves chemical exposure, any chemical spill that due to size and/or hazard requires capabilities beyond your training, or any chemical spill that gives the perception (because of odor, for example) that there has been a hazardous release. Call 911 or 510-642-3073 for assistance.

9. Cleaning and Decontamination Lab-specific information on decontamination may be included in Section 12 - Protocol/Procedure. • Wearing proper PPE, laboratory work surfaces must be cleaned at the conclusion of each procedure and at the end of each work day. • Decontaminate all equipment before removing from a designated area.

10. Hazardous Waste Disposal Label Waste • Label all waste containers. See the EH&S Fact Sheet, “Hazardous Waste Management” for general instructions on procedures for disposing of hazardous waste. Dispose of Waste • Dispose of regularly generated chemical waste within 6 months. • Contact EH&S at 642-3073 if you need assistance.

11. Safety Data Sheet (SDS) Location SDS can be accessed online at http://ucsds.com

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

12. Protocol/Procedure – Mutagens and Reproductive Toxins

Procedure/Use Scale Engineering PPE (eye, face, gloves, clothing) Procedure Steps and Precautions Controls/Equipment

1. Using Mutagens Up to 100 g as All reactions using these Eye protection: Wear ANSI Approved Avoid inhalation and skin exposure to these or Reproductive supplied in the materials must be tight-fitting safety goggles or safety materials. Avoid the formation of dusts with Toxins as reagent bottle. performed in a properly glasses with side shields. solids. reagents. operating fume hood with Face Protection: Face shields are to be If the reagent is volatile or poses an acute the sash as low as possible Remember to used when there is no protection from inhalation hazard, carefully weigh reagents in or in an inert atmosphere obtain PI the hood sash. an enclosed or vented area such as a glovebox. approval if Hand Protection: Confirm compatibility glovebox. If this is not possible use the tared higher scale is of glove material with chemical being vessel method and cap the vessel during necessary. used. General guidance (unless otherwise transport to and from the balance. In a Document this specified in the specific SDS): Nitrile properly functioning fume hood, add reagent approval in gloves must be used to prevent to the reaction vessel. your notebook incidental contact. For spill handling or If the reagent poses an acute skin contact for potential contact with larger hazard, use double gloves, wash hands and quantities, use double nitrile or heavier change gloves immediately after gauge nitrile or neoprene gloves. Gloves manipulations and cleanup of the reagent are must be inspected prior to use. Wash complete. and dry hands after use. If the reagent is a liquid, dispense Clothing: Wear lab coat; full length pants volumetrically and transfer to the reaction or equivalent; and close-toed, close- vessel using a graduated cylinder, syringe, heeled shoes. cannula, or pipettor in a properly functioning fume hood.

Notes Any deviation from this SOP requires approval from PI.

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Procedure/Use Scale Engineering PPE (eye, face, gloves, clothing) Procedure Steps and Precautions Controls/Equipment 2. Using Mutagens Up to 2 L as All reactions using these Eye protection: Wear ANSI Approved Avoid inhalation and skin exposure to these or Reproductive supplied in the materials must be tight-fitting safety goggles or safety materials. If the reagent poses an acute skin Toxins as solvents reagent bottle. performed in a properly glasses with side shields. contact hazard, use double gloves and wash in reactions or for Remember to operating fume hood with Face Protection: Face shields are to be hands and change gloves immediately after extractions obtain PI the sash as low as possible used when there is no protection from manipulations and cleanup of the reagent are approval if or in an inert atmosphere the hood sash. complete. glovebox. higher scale is Hand Protection: Confirm compatibility If a rotary evaporator is used, use an open necessary. of glove material with chemical being cold trap system to condense the solvent Document this used. General guidance (unless otherwise vapor and vent the exhaust into the fume approval in specified in the specific SDS): Nitrile hood. your notebook gloves must be used to prevent Pressure can be built up when these solvents incidental contact. For spill handling or are used in closed reaction vessels. Adequate for potential contact with larger ventilation (e.g. pressure bubbler on Schlenk quantities, use double nitrile or heavier manifold, or an equilibrating balloon) must be gauge nitrile or neoprene gloves. Gloves used to prevent dangerous over must be inspected prior to use. Wash pressurization. and dry hands after use. Pressure may be built up when performing Clothing: Wear lab coat; full length pants extractions. Adequate ventilation (open the or equivalent; and close-toed, close- valve frequently during the extraction) has to heeled shoes. be used to prevent dangerous over pressurization. The vapor in such a process must be released in a fume hood. If heated, the reaction apparatus has to be fitted with an adequately sized condenser with adequate cooling to prevent evaporation. Coolant hoses have to be secured with hose clamps to the condenser and the outlet.

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Notes Any deviation from this SOP requires approval from PI.

Procedure/Use Scale Engineering PPE (eye, face, gloves, clothing) Procedure Steps and Precautions Controls/Equipment 3. Using Mutagens Up to 2 L as All chromatography Eye protection: Wear ANSI Approved Avoid inhalation and skin exposure to these or Reproductive supplied in the operations using these tight-fitting safety goggles or safety materials. If the reagent poses an acute skin Toxins as solvents reagent bottle. materials must be glasses with side shields. contact hazard, use double gloves and wash in column performed in a properly Face Protection: Face shields are to be hands and change gloves immediately after chromatography operating fume hood with manipulations and cleanup of the reagent are Remember to used when there is no protection from (CC) or thin layer the sash as low as possible. complete. obtain PI the hood sash. chromatography approval if Hand Protection: Confirm compatibility Thin Layer Chromatography: if the solvent (TLC). higher scale is of glove material with chemical being poses an acute inhalation hazard, develop necessary. used. General guidance (unless otherwise and allow the plate to dry in the fume hood Document this specified in the specific SDS): Nitrile after removal from the development bath. approval in gloves must be used to prevent Column Chromatography: collect fractions of your notebook incidental contact. For spill handling or interest and concentrate as needed. If more for potential contact with larger than 2 L of total solvent is required for the quantities, use double nitrile or heavier operation, dispense, collect, and concentrate gauge nitrile or neoprene gloves. Gloves no more than 2 L at a time. must be inspected prior to use. Wash If a rotary evaporator is used, use an open and dry hands after use. cold trap system to condense the solvent Clothing: Wear lab coat; full length pants vapor and vent the exhaust into the fume or equivalent; and close-toed, close- hood. heeled shoes. After use in the column, allow the solvent to evaporate from the packing material prior to proper disposal of the packing material. Notes Any deviation from this SOP requires approval from PI.

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

13. Documentation of Training (signature of all users is required) • Prior to conducting any work with Mutagens and Reproductive Toxins, designated personnel must provide training to his/her laboratory personnel specific to the hazards involved in working with this substance, work area decontamination, and emergency procedures.

• The Principal Investigator must provide his/her laboratory personnel with a copy of this SOP and a copy of the Particularly Hazardous Substances SDSs provided by the manufacturer.

I have read and understand the content of this SOP:

Name Signature Identifier Date

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

List of Chemicals

Chemical(s) Chemical(s) Chemical(s) (-)-Delta9-THC-D3 solution (-)-Deoxyephedrine (-)-Thalidomide (+)-Thalidomide (+/-)-11-Hydroxy-Delta9-THC (+/-)-11-nor-9-Carboxy-Delta9-THC- solution D3 solution (+/-)-11-nor-9-Carboxy-Delta9-THC- (+/-)-3-Chloro-1,2-propane- (+/-)-3-Chloro-1,2-propanediol D9 solution 1,1,2,3,3-d5-diol (+/-)-alpha- (+/-)-Baclofen (+/-)-Cloprostenol sodium salt Hexabromocyclododecane hydrate (+/-)-gamma- (+/-)-Glycidol (+/-)-Lorazepam Hexabromocyclododecane (+/-)-Propylene oxide (±)Amethopterin hydrate (11bR, 11'bR)-4,4'-(Oxydi-2,1- phenylene)bis-dinaph (11bS, 11'bS)-4,4'-(Oxydi-2,1- (17R)-4'-Chloro-5'-ethyl-9-fluoro- (1R,3S,4S)-N-Boc-2- phenylene)bis-dinaph 11beta-hydroxy-1 azabicyclo[2.2.1]heptane-3-carb (2S)-(+)-Glycidyl tosylate (3-Bromo-1-propynyl)benzene (Acetylacetonato)dicarbonyliridium(I solution ) (Chloromethylene)dimethyliminium (R)-(+)-Glycidol (R)-(+)-Indoline-2-carboxylic acid chloride (R)-(+)-o-Tolyl-CBS-oxazaborolidine (R)-(+)-Warfarin (S)-(-)-Glycidol solution (S)-(-)-Indoline-2-carboxylic acid (S)-(-)-o-Tolyl-CBS-oxazaborolidine (S)-(-)-Warfarin solution (Z)-4-Hydroxytamoxifen [1- [1,1':4',1"]Terphenyl- 3,3",5,5"- (Diphenylphosphino)ethyl]ferrocene tetracarboxylic a [D-Ala6, N-Me-Leu7]-LH-RH [des-Gly10, D-His(Bzl)6]-LH-RH [des-Gly10, D-Phe6]-LH-RH ethylamide ethylamide [des-Gly10, D-Trp6]-LH-RH [des-pGlu1]-LH-RH [D-Lys6]-LH-RH ethylamide [D-pGlu1, D-Phe2, D-Trp3,6]-LH-RH [D-Trp6]-LH-RH [Hyp9]-LH-RH {2-[(alpha- 1-(cis-3-Chloroallyl)-3,5,7-triaza-1- 1,1,1,3,3,3-Hexafluoro-2-propanol Methyl)diphenylphosphinomethyl]fe azoniaadamant rrocen 1,1,1,3,3,3- 1,1,1-Trimethylhydrazinium iodide 1,1-Bis(tert-butylperoxy)cyclohexane Hexakis(dimethylamino)diphosphaze solution nium 1,1'-Carbonyl-di-(1,2,4-triazole) 1,2,3-Trichloropropane 1,2,4-Triazole 1,2,4-Triazole-15N3 1,2,5,6,9,10- 1,2,7,8-Diepoxyoctane Hexabromocyclododecane 1,2-Dibromo-3-chloropropane 1,2-Dimethoxyethane 1,2-Epoxy-3-phenoxypropane 1,2-Epoxy-5-hexene 1,3,5-Trioxane 1,3-Butadiene 1,3-Butadiene diepoxide 1,3-Butadiene-1,3-13C2 1,3-Butadiene-d6

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

1,3-Diaminopropane-N,N,N',N'- 1,3-Dichloroacetone 1,3-Dimethyl-2-imidazolidinone tetraacetic acid 1,3-Dimethyl-3,4,5,6-tetrahydro- 1,3-Diphenylguanidine 1,5-Dinitronaphthalene 2(1H)-pyrimidinone 11-Hydroxy-Δ9- 11β-Hydroxytestosterone 13-cis-4-Oxoretinoic acid tetrahydrocannabinol 13-cis-Retinoic acid 15α-Hydroxytestosterone 16alpha-Hydroxytestosterone 16beta-Hydroxytestosterone 17alpha-Ethynylestradiol 3- 17alpha-Hydroxyprogesterone cyclopentyl ether 17alpha-Hydroxyprogesterone 17alpha-Hydroxyprogesterone- 17alpha-Methyltestosterone hexanoate 2,3,4-13C3 17beta-Estradiol-16,16,17-d3 19-Hydroxy-4-androsten-3,17-dione 19-Hydroxytestosterone 19-Nortestosterone 1-Bromopropane 1-Bromopropane-2,3-13C2 1-Bromopropane-3,3,3-d3 1-Butyl-3-(2-pyridinylmethyl)-1H- 1-Chloro-4-nitrobenzene imidazolium hexaf 1-Ethyl-1-methylpyrrolidinium 1-Ethyl-2-pyrrolidone 1-Iodo-2-(trimethylsilyl)acetylene bromide 1-Methyl-2-pyrrolidinone 1-PHENYL-2- 2-(4-Morpholino)ethyl 2- (TRIPHENYLPLUMBYL)ACETYLENE bromoisobutyrate 2-(4-tert- 2-(Propyl-2,3-13C2)pentanoic-4,5- 2-(TERT-BUTYL)-4,6-DINITROPHENOL Butylbenzyl)propionaldehyde 13C2 acid sodium 2,2,6,6- 2,3,7,8-Tetrachlorodibenzo-p-dioxin 2,3-Dibromo-1-propanol Tetramethylpiperidinylmagnesium solution chloride l 2,3-Dichloro-1-propene 2',3'-Dideoxy-3'-fluorouridine 2,3-Dinitrotoluene 2,4,6,8-Tetramethyl-2,4,6,8- 2,4-Diaminoanisole 2,4-Diaminoanisole sulfate salt tetrakis(propyl glycid hydrate 2,4-Diaminotoluene 2,4-Dinitroaniline 2,4-Dinitrotoluene 2,6-Diaminotoluene 2,6-Dinitrotoluene 2,6-Dinitrotoluene- alpha,alpha,alpha-d3 2-[(2-Amino-6-oxo-1,6-dihydro-9H- 2-[4-(Dimethylamino)styryl]-1- 21-Chloro-9-fluoro-11beta-hydroxy- purin-9-yl)methox methylquinolinium io 16-methylpregna- 2a Hydroxytestosterone 2-Aminoacetamidine 2-Aminophenol dihydrobromide 2-Azido-beta-D-glucose tetraacetate 2-Azido-D-galactose tetraacetate 2beta-Hydroxytestosterone 2-Bromo-2-chloro-1,1,1- 2-Bromopropane 2-Bromopropane-1,1,1,3,3,3-d6 trifluoroethane-d 2-Bromopropane-2-d1 2-Bromopropane-d7 2-Chloroacetamide 2-Chloroethylamine hydrochloride 2-Chlorotoluene 2-Ethoxyethanol 2-Ethoxyethyl acetate 2-Ethylhexanal 2-Ethylhexanoic acid 2-Ethylhexanoic-d15 acid 2-Hexanone 2-Hydroxy-3-{3-[2,4,6,8-tetramethyl- 4,6,8-tris(pro 2-Imidazolidinethione 2-Imidazolidinethione-4,4,5,5-d4 2-Methoxy-13C,d3-estradiol

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

2-Methoxyestradiol 2-Methoxyethanol 2-Methoxyethanol-13C3 2-Methoxyethyl acetate 2-Methyl-1,5-hexadiene 2-Methyl-2-butene 2-Methyl-4'-(methylthio)-2- 2-Methylimidazole 2-Nitropropane morpholinopropiophenone 2-Nitrotoluene 3-(4-Methylbenzylidene)camphor 3-(Methylthio)butanal 3,3',5-Triiodothyronine-(tyrosine 3,3ʹ-Dipentyloxacarbocyanine iodide 3,3'-Diaminobenzidine phenyl-13C6) hyd 3,3'-Diaminobenzidine (DAB) Liquid 3,3'-Diaminobenzidine 3,3'-Dichlorobenzidine-(diphenyl-d6) Substrate Dropp tetrahydrochloride hydrate 3,3'-Diheptyloxacarbocyanine iodide 3,4- 3,4,5-Trifluorobenzaldehyde (Methylenedioxy)phenylmagnesium bromide soluti 3,4-Dinitrotoluene 3,5,5,-Trimethyloxazolidine-2,4- 3,7-Dimethyl-2,6-octadienenitrile dione 3-Amino-1,2,4-triazole 3-Aminopropionitrile fumarate salt 3-Bromo-7-nitroindazole 3-Chlorothiophene 3-Ethyl-2-methyl-2-(3- 3-Iodobenzylamine methylbutyl)oxazolidine 3-Iodobenzylamine hydrochloride 3-Methylpyrazole 4-(1-Ethyl-1-methylhexyl)phenol 4-(2,6-Dimethyl-2-heptyl)phenol 4-(2-Ethyl-1-methylhexyl)phenol 4-(2-Oxiranylmethoxy)-9H-carbazole 4-(3,5-Dimethyl-3-heptyl)phenol 4,4'-(1,3- 4,4'-Carbonylbis[(2- DIMETHYLBUTYLIDENE)DIPHENOL ethoxycarbonyl)benzoic acid], 4,4'-Carbonylbis[2- 4,4'-Diaminodiphenylmethane 4,4'-Methylene-13C-dianiline (ethoxycarbonyl)benzoic acid], 4,4'-Methylene-bis(2-chloroaniline) 4,4'-Oxydianiline 4-Acetylmorpholine 4-Allylanisole 4-Aminophenol 4-Aminophenol-d7 4-Androstene-3,17-dione 4-Chloro-2-methylaniline 4-Chlorobenzotrichloride 4-Hydroxytamoxifen 4-Methylanisole 4-Nitrophenyl beta-D- lactopyranoside 4-Nitrosophenol 4-Nonylphenol 4-Nonylphenol-2,3,5,6-d4 4-Oxoretinoic acid 4-tert-Butylphenol 4-Vinyl-1-cyclohexene 5-(p-Methylphenyl)-5- 5,5-Diphenylhydantoin 5,5-Diphenylhydantoin sodium salt phenylhydantoin 5,5-Diphenylhydantoin-d5 5alpha-Androstan-17beta-ol-3-one 5-Aza-2'-deoxycytidine 5-Bromo-2'-deoxyuridine 5-Bromoisatoic anhydride 5-Chloro-2-oxindole 5-Ethynyl-2'-deoxyuridine, (EdU) 5-Fluorocytosine 5-Iodo-1,3-dimethyluracil 5-Iodo-2'-deoxyuridine 5β-Pregnane-3β,11β,17α,21-tetrol- 6,7-BIS-BENZYLOXY-1-(3- 20-one BENZYLOXY-4-MEO-BZL)-8-MEO- 6alpha-Hydroxytestosterone 6alpha-Methylprednisolone 21- 6-Aminonicotinamide hemisuccinate sodium 6-Azido-6-deoxy-1,2:3,4-di-O- 6-Methyluracil 6-Nitrochrysene isopropylidene-alpha- 6β-Hydroxytestosterone 7-Nitroindazole 9,9-Di(2-ethylhexyl)fluorene-2,7- diboronic acid bi

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Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

9-Borabicyclo[3.3.1]nonane solution 9-cis-Retinoic acid 9-Vinylcarbazole Abacavir sulfate Abiraterone acetate Acethydrazide Acetohydroxamic acid Acetoxytrimethyllead(IV) Acitretin Acridine Orange hemi(zinc chloride) Acrylamide-1-13C Acrylamide-13C3 salt Acrylamide-2,3,3-d3 Acrylic acid-d4 Acrylonitrile-1-13C Acrylonitrile-13C3 Acrylonitrile-15N Acrylonitrile-2-13C Acrylonitrile-2-d Acrylonitrile-3-13C Acrylonitrile-d3 Actinomycin I, from Streptomyces Actinomycin V, from Streptomyces Adenine 9-beta-D-arabinofuranoside antibioticus antibioticus Aflatoxicol I natural isomer Aflatoxicol II unnatural isomer Albendazole Albendazole sulfone Alclometasone dipropionate Aldimorph Allyl chloride Allyl glycidyl ether alpha-Hydroxytriazolam alpha-Zearalanol Alprostadil Altenuene, from Alternaria sp. Aluminum acetate, dibasic Aminopterin Amitriptyline-d3 hydrochloride solution Ammonium dichromate Ammonium nickel(II) sulfate Anastrozole hexahydrate Androstanolone 17-benzoate Aniline Aniline hydrochloride Aniline phthalate solution Aniline sulfate Aniline-1-13C Aniline-13C6 Aniline-13C6 hydrochloride Aniline-15N Aniline-2,3,4,5,6-d5 Aniline-4-13C Aniline-d7 Anilinium hypophosphite Antide Antimony(III) butoxide solution Apramycin sulfate salt Aramite Aroclor 1260 solution Asparaginase from Escherichia coli Austdiol Azobenzene BDE No 99 Beclomethasone dipropionate Benfuracarb Benomyl Benzamide Benzamide-alpha-13C Benzene Benzene-1,2,3,5-d4 Benzene-1,3,5-d3 Benzene-13C Benzene-13C6 Benzene-13C6,d6 Benzene-d Benzene-d5 Benzene-d6 Benzenethiol Benzo[a]pyrene Benzo[a]pyrene-7-d Benzo[a]pyrene-8-d Benzo[a]pyrene-d12 Benzphetamine hydrochloride Benzyl butyl phthalate Benzyl butyl phthalate-3,4,5,6-d4 Benzyl diazoacetate solution Bergapten beta-CFT naphthalenedisulfonate beta-Estradiol monohydrate beta-Estradiol 17-acetate beta-Estradiol 17-cypionate beta-Estradiol 17-valerate beta-Estradiol 3-benzoate beta-Estradiol hemihydrate beta-Estradiol-d2 Betamethasone beta-Zearalanol Binapacryl Biotin 3-sulfo-N-hydroxysuccinimide Biotin disulfide N- Bis(2,2,6,6-tetramethyl-3,5- ester sodium s hydroxysuccinimide ester heptanedionato)lead(II Bis(2,4,6-trimethylpyridine)iodine(I) Bis(2,6-diphenylphenoxy)niobium(V) Bis(2-ethylhexyl) isophthalate

Rev. Date: 2021-06-29

Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

hexafluoroph chloride, benze Bis(2-ethylhexyl)phthalate-3,4,5,6-d4 Bis(2-methoxyethyl) Bis(3-aminopropyl)amine carbonate Bis(4-aminophenyl)ether-15N2 Bis(4-aminophenyl)ether-d12 Bis(4-methylpentyl)phthalate Bis(8-hydroxy-2-methylquinoline)-(4- Bis(cyclopentadienyl)cobalt(II) Bis(methylglycol) phthalate phenylphenoxy) Bis[2-(2-benzothiazolyl- bisBenzimide H 33342 Bisphenol A N3)phenolato-O]zinc trihydrochloride Bisphenol A propoxylate diglycidyl Bisphenol A sulfate sodium salt Bisphenol A-(dimethyl-d6) ether Bisphenol A-d16 Bisphenol PH Bisphenol-A-(diphenyl-13C12) Bleomycin sulfate from Boc-4-phenyl-Phe-OH Borax Anhydrous Streptomyces verticillus Boric acid Boric acid-10B Boric acid-11B Boric acid-d3 Boric anhydride Bromomethane BROMOMETHANE-(13)C Bromomethane-d1 Bromomethane-d2 Bromomethane-d3 BROMOTRIETHYLLEAD Bromotrimethyllead(IV) Bromoxynil Bromoxynil methyl ether Bromoxynil-octanoate Bropirimine Budesonide Related Compound E Buprenorphine hydrochloride Buserelin acetate salt Butane-1,1,1-d3 Butane-d10 Butirosin A, from Bacillus vitellinus Butorphanol (+)-tartrate salt Butralin Butyl glycidyl ether Butyl glycolate Cadmium Cadmium carbonate Cadmium chloride Cadmium chloride hemi(pentahydrate) Cadmium chloride hydrate Cadmium chloride monohydrate Cadmium fluoride Cadmium hydroxide Cadmium nitrate tetrahydrate Cadmium oxide Cadmium standard solution Cadmium sulfate Cadmium sulfate 8/3-hydrate Cadmium sulfate hydrate Cadmium sulfide Cadmium(II) acetate Caffeic acid Caffeic acid-13C9 Calcium acetylacetonate Calcium acetylacetonate hydrate Cambendazole Cambendazole-d7 Canamycin A disulfate salt hydrate Candesartan cilexetil Capecitabine Capreomycin sulfate from Captopril Carbendazim Streptomyces capreolus Carbendazim-(ring-4,5,6,7-d4) Carbendazim-d3 Carbon disulfide Carbon monoxide Carbon-13C disulfide Carbon-13C monoxide Carboplatin Carmofur Carmustine Celecoxib Cerium(III) acetylacetonate hydrate Cesium chloride Cesium chloride/sodium chloride Cetrorelix acetate Chinomethionate (2:1) eutectic Chlorazol Black Chlorden Chlormadinone acetate Chloroform-d Chlorotriphenyllead(IV) Chlortoluron

Rev. Date: 2021-06-29

Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Chorionic gonadotropin human Chorionic gonadotropin Human β- Chorismic acid from Enterobacter Subunit Fragment 10 aerogenes Chromium(III) bromide hexahydrate Chromium(III) Chromium(VI) oxide trifluoroacetylacetonate Chromomycin A3 from Streptomyces Chromyl chloride Chrysene griseus Chrysene-d12 Chrysoidine G Cimetidine Citreoviridin A Clavulanate Lithium Clobetasol Clobetasol propionate Clomiphene citrate salt Clorazepate dipotassium salt Clozapine Cobalt atomic spectroscopy Cobalt standard for ICP standard concentrate 10 Cobalt(II) 2-ethylhexanoate solution Cobalt(II) acetate Cobalt(II) acetylacetonate Cobalt(II) carbonate Cobalt(II) chloride Cobalt(II) chloride hexahydrate Cobalt(II) chloride hydrate Cobalt(II) sulfate heptahydrate Cobalt(II) sulfate hydrate Cobalt(II) thiocyanate Cocaine hydrochloride Colchicine Compound 52 Concanavalin A from Canavalia Congo Red ensiformis (Jack bea Copper hydride (CuH) solution CP-395,267-15 tosylate Creosote from beechwood tar Cresol mixture of isomers Cresol red tetraoctylammonium salt Crizotinib solution Crotonaldehyde, mixture of cis and Crotonaldehyde, predominantly Cyanamide trans trans Cyclohexanone peroxide solution CYCLOHEXIMIDE Cyclohexylamine Cyclopentadienylhafnium(IV) Cyclopropylboronic acid Cyclosporin A trichloride Cyclosporin H Cymoxanil Cyproconazol Cytochalasin A from Drechslera Cytochalasin B from Drechslera Cytochalasin D dematioidea dematioidea Cytochalasin E from Aspergillus Cytosine beta-D-arabinofuranoside Cytosine beta-D-arabinofuranoside clavatus hydrochloride D(-)-Norgestrel Dacarbazine D-Amphetamine-d3 sulfate salt Danazol Delta9-Tetrahydrocannabinol Dexamethasone 21-phosphate solution disodium salt Dexamethasone–biotin labeled Dibekacin sulfate salt Dibutyl phthalate Dibutyl phthalate-3,4,5,6-d4 Dibutylboron triflate solution Dibutyltin bis(acetylacetonate) Dibutyltin diacetate Dibutyltin dichloride Dibutyltin dilaurate Dibutyltin maleate Dibutyltin(IV) oxide Dicarbonylcyclopentadienyl cobalt(I) Dienestrol Dienestrol-3',3",5',5"-d4 Dienogest Diethyl sulfate Diethylaluminum cyanide solution DIETHYLDITHIOCARBAMIC ACID, LEAD SALT, MOIST Diethylene glycol dimethyl ether Diethylene glycol methyl ether Diethylenetriamine-pentaacetic acid pentasodium sa DIETHYLLEAD DIBROMIDE Diethylstilbestrol Diethylstilbestrol dipropionate

Rev. Date: 2021-06-29

Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Diethylstilbestrol, mixture of cis and Diflunisal Diheptyl phthalate trans Dihexyl phthalate Diisobutyl phthalate Diisobutyl phthalate-3,4,5,6-d4 Diisoheptyl phthalate Diisononyl phthalate Diisononyl phthalate-d4 Diisopentyl phthalate Diisopropylzinc solution D-Ile-Pro-Arg p-nitroanilide dihydrochloride Dilithium phthalocyanine Dimethyl methylphosphonate Dimethyl phosphite Dimethyl sulfate Dimethyl sulfate-13C2 Dimethyl sulfate-13C2,d6 Dimethyl sulfate-d6 Dinocap Dinoseb Dinoseb acetate Dinoterb acetate Dioctyl phthalate Dipentyl phthalate Dipentyl phthalate-3,4,5,6-d4 Diphenyl(2,4,6- trimethylbenzoyl)phosphine oxide Diphenylzinc Dipropyl phthalate Dipyron monohydrate Disopyramide DL-Amethopterin hydrate DNOC Dobutamine hydrochloride Dofetilide Domperidone Dothiepin solution D-Phe2,D-Ala6-luteinizing D-Phe-L-pipecolyl-Arg-p-nitroanilide hormonereleasing hormon dihydrochlori Drospirenone D-Val-Leu-Arg p-nitroanilide D-Val-Leu-Lys 4-nitroanilide diacetate salt dihydrochloride D-Val-Phe-Lys p-Nitroanilide Dysprosium(III) acetylacetonate Dysprosium(III) iodide dihydrochloride hydrate Efinaconazole Enalapril Epirubicin hydrochloride Epitetracycline hydrochloride Epoxiconazole Eprinomectin Equilin Equilin-2,4,16,16-d4 Erbium(III) acetylacetonate hydrate Erbium(III) iodide Ergotamine D-tartrate Estriol Estriol-2,3,4-13C3 Estrone Estrone 3-sulfate potassium salt Estrone acetate Estrone-2,3,4-13C3 Estrone-2,4,16,16-d4 Estrone-2,4,16,16-d4 3-sulfate Ethambutol dihydrochloride Ethenesulfonyl fluoride sodium salt Ethidium bromide Ethionamide Ethisterone Ethyl methanesulfonate ETHYL TETRAHYDROFURFURYL Ethylene oxide ETHER Ethylene-13C oxide Ethylene-d4 oxide Ethyllithium solution Etiocholan-17β-ol-3-one Etofenprox Etofenprox-(ethoxy-d5) Etonogestrel Europium(II) iodide Exemestane Exemestane Related Compound A Fadrozole hydrochloride Fast Green FCF Fenarimol Fenpropimorph Fenthion Ferrocene Flecainide acetate Fluazifop Fluazifop-butyl Fluazifop-P-butyl Fluazinam Fludrocortisone acetate Flumioxazin Fluocinolone acetonide 21-acetate Fluoxymesterone Fluphenazine dihydrochloride Flusilazole

Rev. Date: 2021-06-29

Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Flutamide Formaldehyde solution Formaldehyde-13C solution Formamide Formamide-13C Formamide-13C,15N Formamide-15N Formamide-18O Formamide-1-d Formamide-d3 Formestane Fosphenytoin disodium salt hydrate Furan Furan-d4 Furazolidone Furazolidone-d4 Furosemide Gabapentin Gadolinium(III) iodide Gallium(III) iodide Ganciclovir Gemcitabine hydrochloride Gestodene Glufosinate-ammonium Glycidamide-13C3 Glycidyl 2-methylphenyl ether Glycidyl methacrylate Glycidyltrimethylammonium Glyoxal solution Goserelin acetate chloride Griseofulvin Guanabenz Hafnium(IV) iodide Halcinonide Haloperidol HCH Heptadecafluorooctanesulfonic acid Heptadecafluorooctanesulfonic acid Hexafluoroacetone tetraethylammon Hexafluoroacetone deuterate Hexafluoroacetone trihydrate Hexamethylphosphoramide Hexane-1-13C Hexane-d14 Holmium(III) iodide Hydrocortisone Hydrocortisone 21-acetate Hydrocortisone-9,11,12,12-d4 Hydroquinone Hydroquinone-d4-(ring-d4) Hydroquinone-d6 Hydroxymethanesulfinic acid Hydroxypropyl methacrylate Hydroxyurea monosodium salt dihydr Idarubicin hydrochloride Imidazole-15N2 Indium(III) iodide Indium(III) phosphide Indoline-2-carboxylic acid Inhibin alpha-Subunit Fragment 1-32 porcine Inhibin beta-Subunit Fragment 67-94 Inhibin from porcine ovary Inhibin α-Subunit Fragment 1-32 human human Inhibin-Like Peptide, human Ioxynil Ioxynil-octanoate IR-676 iodide IR-786 iodide Iron(II) iodide Isobutyl nitrite Isopropyl beta-D- Isopropyl chloroformate solution thioglucopyranoside Isopropyl methanesulfonate Isopyrazam Isoxaflutole Jone's reagent Kaempferol Kaempferol 3-O-alpha-L- arabinopyranoside Kanamycin disulfate salt from Kanamycin sulfate Kanamycin sulfate, from Streptomyces kanamyc Streptomyces kanamyceticus Ketoconazole Lamivudine Lanreotide acetate Lead Lead bis(2-ethylhexanoate) Lead compounds Lead diethyldithiocarbamate Lead hydrogen phosphate Lead oxide Lead subacetate Lead(II) acetate trihydrate Lead(II) acetylacetonate Lead(II) bromide Lead(II) carbonate Lead(II) chloride Lead(II) chromate Lead(II) fluoride Lead(II) iodate

Rev. Date: 2021-06-29

Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Lead(II) iodide Lead(II) metavanadate Lead(II) molybdate Lead(II) niobate Lead(II) nitrate Lead(II) oxide Lead(II) perchlorate hydrate Lead(II) perchlorate trihydrate Lead(II) phthalocyanine Lead(II) salicylate Lead(II) selenide Lead(II) selenite Lead(II) sulfate Lead(II) sulfide Lead(II) tantalate Lead(II) tartrate Lead(II) telluride Lead(II) tetrakis(4- cumylphenoxy)phthalocyanine Lead(II) thiocyanate Lead(II) titanate Lead(II) trifluoroacetate Lead(II) tungstate Lead(II) zirconate Lead(IV) acetate Leucomalachite Green Leukotriene A3 methyl ester Leuprorelin Levofloxacin Levofloxacin-(N-methyl-13C,d3) Levorphanol (+)-tartrate salt dihydrate Ligroin Lindane Lindane-13C6 (gamma-BHC) Linuron Linuron-(methyl-d3, methoxy-d3) Lithium acetylacetonate Lithium aluminum hydride Lithium dichromate hydrate Lithium diisopropylamide bis(tetrahydrofuran) solu mono(tetrahydrofuran) sol Lithium iodate Lithium iron(III) oxide Lithium pentamethylcyclopentadienide Lithium potassium acetyl phosphate Lithium-6Li fluoride Lonidamine Luperox(R) 224, 2,4-Pentanedione Luperox(R) DI, tert-Butyl peroxide Luteinizing Hormone from equine peroxide solution pituitary Luteinizing hormone releasing Luteinizing hormone releasing Luteinizing hormone releasing hormone hormone Fragment 4-1 hormone Fragment 7-1 Luteinizing hormone releasing Luteinizing hormone releasing Luteinizing hormone releasing hormone human acetat hormone salmon hormonefragment 3-1 Luteinizing Hormone, beta-subunit Lutetium(III) acetylacetonate Magnesium bis(diisopropyl)amide from human pitui hydrate solution Magnesium methyl carbonate Malachite Green Carbinol Malachite Green chloride solution hydrochloride Malachite Green oxalate salt Maleic hydrazide Mancozeb Maneb Manganese(II) iodide Mechlorethamine hydrochloride Meclozine dihydrochloride Medroxyprogesterone Melengestrol acetate Melphalan Mercury Mercury(II) chloride Methimazole Methotrexate hydrate Methoxyacetic acid Methyl 2-acrylamido-2- Methyl isocyanate Methyl-d3 salicylate-OD methoxyacetate Methylergonovine maleate salt Methylglycol chitosan Methylprednisolone acetate Methyltrioctylammonium iodide Metoclopramide Mibolerone Michler's ketone Mifepristone Miloxacin-d3 Mirex Misoprostol Misoprostol free acid Mitoxantrone dihydrochloride Mizoribine MMAO-12 Molinate mono-Butyl phthalate Monocrotophos

Rev. Date: 2021-06-29

Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Morphine sulfate salt solution m-Phenylenediamine m-Phenylenediamine dihydrochloride MS-275 m-Xylene-(dimethyl-13C2) Myclobutanil Mycophenolic acid N-(Hydroxymethyl)acrylamide N,N-Dimethyl-13C2-formamide solution N,N-Dimethylacetamide N,N-Dimethylacetamide-1,2-13C2 N,N-Dimethylacetamide-d9 N,N-Dimethyl-d6-formamide N,N-Dimethylformamide N,N-Dimethylformamide diethyl sulfate adduct N,N-Dimethylformamide-(carbonyl- N,N-Dimethylformamide-15N N,N-Dimethylformamide-d 13C) N,N-Dimethylformamide-d7 N-[3-(Trimethoxysilyl)propyl]aniline N4-Benzoyl-5'-O-(4,4'- dimethoxytrityl)-2'-deoxycyt Naphtha Naproxen sodium Narciclasine N-Desmethyltamoxifen HCl Neodymium(III) iodide Netilmicin sulfate salt Nickel standard for IC Nickel sulfide Nickel(II) bromide Nickel(II) bromide trihydrate Nickel(II) carbonate basic hydrate Nickel(II) chloride Nickel(II) chloride hexahydrate Nickel(II) chloride hydrate Nickel(II) fluoride Nickel(II) fluoride tetrahydrate Nickel(II) hexafluorosilicate Nickel(II) hydroxide hexahydrate Nickel(II) iodide Nickel(II) molybdate Nickel(II) nitrate hexahydrate Nickel(II) octanoate hydrate Nickel(II) perchlorate hexahydrate Nickel(II) stearate Nickel(II) sulfamate tetrahydrate Nickel(II) sulfate Nickel(II) sulfate heptahydrate Nickel(II) sulfate hexa-/ Nickel(II) sulfate hexahydrate Nilutamide heptahydrate Nitrobenzene Nitrobenzene-13C6 Nitrobenzene-15N Nitrobenzene-d5 Nitrofen N-Methylacetamide-d7 N-Methyl-d3-2-pyrrolidinone-d6 N-Methylformamide N-Methylformamide-18O N-Nitroso-N-ethylurea N-Nitroso-N-methylurea n-Nonylphenol Nocodazole Nogalamycin Nomegestrol acetate Nonylphenol Norcocaine Norcocaine hydrochloride solution Norethandrolone solution Norethynodrel N-Succinyl-Ala-Ala-Pro-Asp-p- nitroanilide N-Vinylformamide o-Anisidine Octamethylcyclotetrasiloxane o-Phenylenediamine o-Phenylenediamine Oxadiargyl dihydrochloride Oxalic acid-13C2 dihydrate Oxandrolone Oxibendazole-d7 Paclitaxel Parbendazole Parbendazole-(methyl-d3) Pentadecafluorooctanoic acid Pentobarbital Perfluorooctanoic acid ammonium salt Petroleum Petroleum ether pGlu-Gly-Arg p-nitroanilide hydrochloride Phenazepam Phenobarbital Phenobarbital-D5 (ring) solution

Rev. Date: 2021-06-29

Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Phenol Phenol - chloroform - isoamyl Phenol-13C6 alcohol mixture Phenol-2,3,4,5,6-d5 Phenol-2,4,6-d3 Phenol-2,4,6-d3,OD Phenol-3,5-d2 Phenol-4-d1 Phenol-d6 Phenolphthalein Phenol-UL-14C Phenylammonium iodide Phenylhydrazine Phenylhydrazine hydrochloride Phosphamidon Phosphazene base P1-t-Bu Phoxim Phthalazine Pigment Orange 5 Piperazine dihydrochloride Piperazine hexahydrate Pizotifen Platinum(II) acetylacetonate Podophyllin from Podophyllum emodii Poly(2-ethylhexyl acrylate) solution Poly(2-ethylhexyl methacrylate) Poly(3,3',4,4'- solution biphenyltetracarboxylic dianhydride Poly(butyl acrylate) solution Poly(hexadecyl methacrylate) Poly(hexyl methacrylate) solution solution Poly(lauryl methacrylate) solution Poly(melamine-co-formaldehyde) Poly(methyl acrylate) solution isobutylated, solut Poly(methyl vinyl ether-alt-maleic Poly(octadecyl methacrylate) Poly(propylene glycol) 4- anhydride) solution nonylphenyl ether acrylat Poly(vinyl N-octadecylcarbamate) Potassium acetylacetonate Potassium chromate hemihydrate Potassium Potassium dichromate Potassium dichromate solution in cyclopropyltrifluoroborate sulfuric acid, re Potassium tert-pentoxide solution Praseodymium(III) acetylacetonate Praseodymium(III) iodide hydrate Prazosin hydrochloride Prednisone Pregabalin Prinomastat hydrochloride Procarbazine hydrochloride Progesterone-2,3,4-13C3 Prolactin from sheep pituitary Propargyl bromide solution Propidium iodide Propylene oxide-d6 Propylene thiourea Propylphosphonic anhydride solution Prostaglandin D2 Prostaglandin E2 Prostaglandin F2alpha tris salt Prunasin Pseudolaric Acid B p-Toluenesulfonyl azide solution Pyrene Pyrocatechol Pyrogallol Pyronaridine tetraphosphate Quinoline R(-)-Denopamine Radicicol from Diheterospora Red-Al(R) sodium bis(2- Resorcinol diglycidyl ether chlamydosporia methoxyethoxy)aluminum hydr Retinoic acid p-hydroxyanilide Retinol Retinyl acetate Retinyl Propionate Rhodium(III) acetylacetonate Ribavirin Ribostamycin sulfate salt Risedronate sodium Rizatriptan benzoate salt Ruthenium iodide Ruthenium(III) iodide hydrate S(−)-Terguride hydrogen maleate Safrole SAHA Samarium(III) acetylacetonate hydrate Sassafras oil Scandium(III) iodide Secobarbital sodium salt

Rev. Date: 2021-06-29

Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

Semustine Seratrodast Serotonin Serotonin creatinine sulfate Silafluofen Silicon tetraiodide monohydrate Sisomicin sulfate salt sn-Glycero-3-phosphocholine 1:1 Sodium butyrate cadmium chloride a Sodium chromate Sodium chromate tetrahydrate Sodium dichromate Sodium dichromate dihydrate Sodium diethyldihydroaluminate Sodium hexafluoroaluminate solution Sodium hydroxymethanesulfinate Sodium mercury amalgam Sodium perborate monohydrate hydrate Sodium tetraborate decahydrate Sodium triethylborohydride solution Sodium-lead alloy Spiperone Spironolactone Stanozolol Stanozolol-D3 solution Streptomycin sulfate salt S-Trioxane-13C3 Styrene oxide Styrene-(phenyl-13C6) Styrene-2,3,4,5,6-d5 Styrene-alpha, beta, beta-d3 Styrene-alpha,2,3,4,5,6-d6 Styrene-alpha-d1 Styrene-beta, beta-d2 Styrene-d8 Sulcotrione Sulindac Sulindac sulfide Sulprostone Sunitinib malate Tamoxifen Tamoxifen citrate salt Tebbe reagent solution Tebuconazole Tebuconazole-(tert-butyl-d9) Tebuconazole-(trimethyl-13C3) Tellurium Temozolomide Tenivastatin ammonium salt Tepraloxydim Terbium(III) iodide Terbutaline hemisulfate salt tert-Butyl diazoacetate tert-Butyl hydroperoxide solution Testosterone Testosterone 17beta-cypionate Testosterone acetate Testosterone enanthate Testosterone propionate Testosterone β-D-glucuronide Tetraethyllead Tetraisobutyldialuminoxane solution Tetrakis[tris(dimethylamino)phosph oranylidenamino] Thiazolyl Blue Tetrazolium Bromide Thiocolchicine Thiophanate-methyl Thiourea Thiourea-13C,15N2 Thiourea-15N2 Thiourea-d4 Thromboxane B2 Thulium(III) iodide Tigecycline Tigecycline hydrate Timolol maleate salt Tin(II) 2-ethylhexanoate Tin(II) chloride Tin(II) chloride dihydrate Tin(II) iodide Tin(II) sulfate Tinidazole Tolterodine L-tartrate Tolterodine tartrate Toluene Toluene-(phenyl-13C6) Toluene-13C7 Toluene-4-13C Toluene-alpha, alpha, alpha-d3 Toluene-d8 Topotecan hydrochloride hydrate Topramezone Trenbolone Trenbolone acetate Triamcinolone acetonide Tributylmethylphosphonium methyl Trichloroethylene sulfate Trichloroethylene-13C2 Trichloroethylene-d Tridemorph Triethylene glycol dimethyl ether Trifluoroiodomethane Trilostane Trimethyl phosphate TRIMETHYL-(5-METHYL-FURAN-2- Trimethylgermanium iodide

Rev. Date: 2021-06-29

Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure

YLMETHYL)-AMMONIUM, IO Trimethylphenylphosphonium iodide Trimipramine maleate salt Trioctylaluminum solution Triphenylphosphine diiodide Triphenyltin hydroxide TRIPROPYLPLUMBYL ACETATE Tris(2,3-epoxypropyl) isocyanurate Tris(2-chloroethyl) phosphate Tris(2-chloroethyl) phosphite Tris(2-methoxyethoxy)(vinyl)silane Tris(nonylphenyl) phosphite Tris(triphenylsilyloxy)molybdenum nitride pyridine Tritolyl phosphate Trovafloxacin mesylate TTNPB Ulipristal acetate Vanadium(V) oxide Veratridine Vinclozolin Vincristine sulfate Vindoline Vinyl 2-ethylhexanoate Voriconazole Warfarin Sodium Warfarin(TM) Woods metal Yttrium(III) acetylacetonate hydrate Yttrium(III) butoxide solution Zearalenone Ziprasidone solution Z-Leu-OH Zopiclone α-Chaconine α-Ergocryptine

Rev. Date: 2021-06-29