Swissprot Genetrail Acc. No. ID Exp1 Exp2 Exp1 Exp2 Exp1 Exp2

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Swissprot Genetrail Acc. No. ID Exp1 Exp2 Exp1 Exp2 Exp1 Exp2 Supplementary TABLE 1. Quantitative MS-based proteomic results from the macrophage cytosolic proteomes for both biological replicates separately Human proteins HSV-1 dLeu d3-4 Protein name SwissProt Genetrail N % Seq Cov Pept(95%) Fold change P-value Fold change P-value Fold change P-value Acc. No. ID Exp1 Exp2 Exp1 Exp2 Exp1 Exp2 Exp1 Exp2 Exp1 Exp2 Exp1 Exp2 Exp1 Exp2 Exp1 Exp2 Exp1 Exp2 10 kDa heat shock protein, mitochondrial P61604 HSPE1 121 108 69,6 65,7 9 18 1,24 1,11 0,014 0,141 1,12 1,16 0,127 0,054 1,07 0,96 0,290 0,529 14-3-3 protein beta/alpha P31946 YWHAB 350 145 37 52,9 13 16 1,10 0,97 0,409 0,743 1,12 0,72 0,651 0,184 1,04 0,72 0,730 0,101 14-3-3 protein epsilon P62258 YWHAE 661 524 16,5 24,7 5 8 1,43 1,00 0,996 0,60 0,78 0,238 0,84 0,87 0,765 14-3-3 protein eta Q04917 YWHAH 572 376 36,2 34,6 9 10 0,77 1,00 1,30 14-3-3 protein gamma P61981 YWHAG 135 358 38,1 35,2 13 10 1,93 1,21 0,170 1,10 0,44 0,515 1,88 1,17 0,099 14-3-3 protein theta P27348 YWHAQ 659 596 20,4 43,7 7 8 1,12 0,72 1,16 14-3-3 protein zeta/delta P63104 YWHAZ 59 36 45,3 54,7 15 19 1,48 1,33 0,004 0,019 1,22 0,95 0,265 0,570 1,08 1,10 0,315 0,416 182 kDa tankyrase-1-binding protein Q9C0C2 TNKS1BP1 517 2,7 2 0,89 0,874 1,18 0,345 1,06 0,651 1-phosphatidylinositol 4,5-bisphosphate phosphodiesteraseQ00722 beta-2 PLCB2 291 9,1 3 0,67 0,290 0,65 0,046 0,94 0,793 2,4-dienoyl-CoA reductase, mitochondrial Q16698 DECR1 335 14,3 4 0,76 0,284 0,97 0,841 0,91 0,415 26S proteasome non-ATPase regulatory subunit 11 O00231 PSMD11 375 18,7 3 1,43 1,19 0,93 26S proteasome non-ATPase regulatory subunit 4 P55036 PSMD4 314 21,5 4 0,93 0,43 1,69 28 kDa heat- and acid-stable phosphoprotein Q13442 PDAP1 464 19,3 2 1,36 1,00 0,72 28S ribosomal protein S36, mitochondrial P82909 MRPS36 482 485 24,3 24,3 2 2 1,16 1,96 0,198 1,48 1,24 0,299 1,35 1,20 0,340 39S ribosomal protein L11, mitochondrial Q9Y3B7 MRPL11 574 20,3 2 2,37 1,76 2,08 39S ribosomal protein L12, mitochondrial P52815 MRPL12 311 204 19,2 36,4 3 7 1,40 1,34 0,231 1,47 0,99 0,914 1,20 1,33 0,116 39S ribosomal protein L17, mitochondrial Q9NRX2 MRPL17 566 763 9,1 4,6 2 1 0,96 0,65 0,789 0,85 1,11 0,374 0,86 0,76 0,382 39S ribosomal protein L38, mitochondrial Q96DV4 MRPL38 511 10 2 0,90 0,46 0,57 39S ribosomal protein L49, mitochondrial Q13405 MRPL49 315 25,3 3 0,90 0,795 1,45 0,237 1,06 0,649 3-hydroxyacyl-CoA dehydrogenase type-2 Q99714 HSD17B10 473 11,1 2 0,59 0,88 0,55 3-hydroxyisobutyrate dehydrogenase, mitochondrial P31937 HIBADH 439 356 9,5 25 2 3 1,16 0,638 1,27 0,248 1,34 0,298 3-ketoacyl-CoA thiolase, mitochondrial P42765 ACAA2 115 510 20,4 7,6 8 2 1,26 1,05 0,049 0,878 1,19 1,25 0,096 0,347 1,12 0,95 0,218 0,810 40S ribosomal protein S10 P46783 RPS10 341 44,2 4 0,88 0,431 0,73 0,196 0,89 0,657 40S ribosomal protein S11 P62280 RPS11 512 18,4 2 0,56 0,167 0,75 0,248 0,83 0,321 40S ribosomal protein S12 P25398 RPS12 435 397 17,4 24,2 2 3 0,61 0,88 0,128 0,77 1,01 0,403 1,01 0,92 0,943 40S ribosomal protein S13 P62277 RPS13 221 194 32,5 29,8 5 5 0,53 0,75 0,003 0,149 0,63 0,99 0,011 0,970 0,76 0,85 0,025 0,130 40S ribosomal protein S14 P62263 RPS14 316 472 27,2 23,8 3 2 0,26 1,41 0,56 1,31 0,77 1,60 40S ribosomal protein S15a P62244 RPS15A 527 17,7 2 0,60 0,036 0,75 0,300 0,87 0,255 40S ribosomal protein S16 P62249 RPS16 195 608 34,3 14,4 5 1 0,53 1,74 0,013 0,67 1,75 0,011 0,67 1,32 0,051 40S ribosomal protein S17-like P0CW22 RPS17L 403 329 21,5 35,6 2 3 40S ribosomal protein S18 P62269 RPS18 82 471 57,2 13,8 11 3 0,50 0,78 0,006 0,597 0,62 0,78 0,004 0,480 0,78 0,75 0,021 0,212 40S ribosomal protein S19 P39019 RPS19 191 176 38,6 31,7 5 5 0,52 0,79 0,019 0,253 0,67 0,90 0,067 0,467 0,77 1,00 0,059 0,985 40S ribosomal protein S2 P15880 RPS2 297 16,4 3 0,58 0,127 0,77 0,542 0,88 0,455 40S ribosomal protein S20 P60866 RPS20 241 248 28,6 28,6 4 4 0,48 0,79 0,109 0,286 0,56 0,83 0,340 0,356 0,78 0,82 0,258 0,289 40S ribosomal protein S21 P63220 RPS21 542 375 30,1 31,3 2 4 0,56 0,70 0,109 0,178 0,72 0,81 0,332 0,278 0,76 0,82 0,323 0,295 40S ribosomal protein S25 P62851 RPS25 294 237 29,6 24 4 5 0,45 0,65 0,015 0,146 0,50 0,73 0,121 0,193 0,66 0,91 0,093 0,510 40S ribosomal protein S26 P62854 RPS26 465 32,2 3 1,09 0,81 0,88 40S ribosomal protein S28 P62857 RPS28 756 438 17,4 30,4 1 3 0,66 0,153 0,66 0,151 0,86 0,505 40S ribosomal protein S3 P23396 RPS3 151 632 37,9 19,3 6 1 0,68 1,59 0,097 0,133 0,81 1,34 0,253 0,242 0,74 1,09 0,035 0,542 40S ribosomal protein S3a P61247 RPS3A 161 166 27,7 32,6 5 5 0,60 0,79 0,007 0,126 0,65 0,88 0,005 0,269 0,80 0,91 0,014 0,203 40S ribosomal protein S4, X isoform P62701 RPS4X 163 26,6 6 0,57 0,004 0,70 0,034 0,74 0,010 40S ribosomal protein S5 P46782 RPS5 471 424 8,8 15,7 2 3 0,61 0,64 0,126 0,512 0,62 0,69 0,148 0,205 0,70 0,64 0,170 0,142 40S ribosomal protein S6 P62753 RPS6 563 216 18,1 32,9 3 6 1,48 0,500 1,55 0,309 1,08 0,848 40S ribosomal protein S7 P62081 RPS7 609 334 20,1 17,5 3 3 0,60 0,83 0,129 0,443 0,64 0,90 0,312 0,426 0,71 0,92 0,191 0,627 40S ribosomal protein S8 P62241 RPS8 322 15,9 3 0,58 0,445 0,70 0,180 0,86 0,569 40S ribosomal protein S9 P46781 RPS9 230 32,5 5 0,58 0,024 0,79 0,024 0,92 0,309 40S ribosomal protein SA P08865 RPSA 136 210 26,4 30,5 9 7 0,66 0,93 0,045 0,707 0,61 0,87 0,008 0,393 0,86 0,92 0,152 0,555 4F2 cell-surface antigen heavy chain P08195 SLC3A2 67 233 21 14,6 10 4 1,08 1,22 0,585 0,436 0,94 1,25 0,531 0,627 0,90 1,12 0,197 0,689 60 kDa heat shock protein, mitochondrial P10809 HSPD1 19 4 42,4 53,1 35 78 1,53 1,04 0,009 0,589 1,36 1,10 0,007 0,226 1,18 1,06 0,176 0,466 60S acidic ribosomal protein P0 P05388 RPLP0 137 212 21,1 22,1 7 4 0,73 1,53 0,003 0,81 1,54 0,187 0,89 1,92 0,401 60S acidic ribosomal protein P1 P05386 RPLP1 446 49,1 3 0,61 0,63 0,79 60S acidic ribosomal protein P2 P05387 RPLP2 187 91 60 93 9 17 0,73 0,74 0,205 0,087 1,06 0,75 0,805 0,098 1,17 0,75 0,499 0,094 60S ribosomal protein L10 P27635 RPL10 280 202 19,2 22,4 3 5 0,63 0,79 0,007 0,047 0,75 0,86 0,029 0,256 0,88 0,78 0,177 0,173 60S ribosomal protein L10a P62906 RPL10A 272 27,2 5 0,69 0,457 0,81 0,584 0,91 0,790 60S ribosomal protein L11 P62913 RPL11 503 11,8 2 0,80 0,718 0,80 0,414 0,92 0,848 60S ribosomal protein L12 P30050 RPL12 355 316 28,5 20 3 3 0,42 0,72 0,69 0,59 0,79 0,81 60S ribosomal protein L13 P26373 RPL13 313 26,1 3 0,36 0,062 0,61 0,126 0,52 0,097 60S ribosomal protein L13a P40429 RPL13A 330 34 3 0,89 0,584 1,15 0,520 1,06 0,828 60S ribosomal protein L14 P50914 RPL14 465 697 16,3 14,9 2 1 1,26 1,25 1,32 60S ribosomal protein L22 P35268 RPL22 324 337 30,5 30,5 3 4 0,32 0,76 0,339 0,48 0,76 0,349 0,84 0,77 0,238 60S ribosomal protein L23a P62750 RPL23A 483 167 21,8 32,7 3 7 0,45 0,68 0,028 0,004 0,55 0,72 0,353 0,033 0,70 0,68 0,049 0,037 60S ribosomal protein L26 P61254 RPL26 323 307 17,2 24,1 3 3 0,49 0,43 0,013 0,075 0,68 0,49 0,043 0,145 0,79 0,54 0,109 0,101 60S ribosomal protein L27 P61353 RPL27 308 22,1 3 0,70 0,229 0,78 0,292 1,01 0,945 60S ribosomal protein L29 P47914 RPL29 460 490 14,5 14,5 2 2 0,37 0,58 0,40 60S ribosomal protein L31 P62899 RPL31 348 470 19,2 24,8 3 2 0,39 0,67 0,067 0,308 0,75 0,69 0,226 0,364 0,66 0,77 0,245 0,432 60S ribosomal protein L35 P42766 RPL35 621 638 26,8 22 2 2 0,50 0,54 0,67 0,70 1,06 0,64 60S ribosomal protein L36 Q9Y3U8 RPL36 523 16,2 2 60S ribosomal protein L4 P36578 RPL4 212 21,3 5 0,73 0,347 0,86 0,367 0,86 0,377 60S ribosomal protein L6 Q02878 RPL6 251 24,7 5 0,68 0,014 0,71 0,208 0,82 0,277 60S ribosomal protein L7 P18124 RPL7 127 33,5 7 0,69 0,002 0,95 0,464 0,93 0,335 60S ribosomal protein L7a P62424 RPL7A 571 377 7,5 16,2 2 2 0,89 0,604 0,95 0,921 1,18 0,658 60S ribosomal protein L8 P62917 RPL8 513 15,6 2 0,51 0,47 0,95 6-phosphogluconate dehydrogenase, decarboxylating P52209 PGD 68 262 18,6 9,9 10 5 0,93 0,86 0,575 0,376 1,15 1,06 0,073 0,697 1,22 0,80 0,105 0,150 78 kDa glucose-regulated protein P11021 HSPA5 6 8 48,8 48,9 57 49 1,27 1,32 0,000 0,000 1,01 1,14 0,861 0,005 1,06 1,12 0,138 0,008 Abhydrolase domain-containing protein 10, mitochondrialQ9NUJ1 ABHD10 533 19 2 Absent in melanoma 1 protein Q9Y4K1 AIM1 351 2,5 3 0,60 1,09 0,92 Acetyl-CoA acetyltransferase, mitochondrial P24752 ACAT1 470 819 19 9,6 2 1 0,94 1,50 0,716 1,13 1,69 0,448 0,94 1,75 0,495 Acid ceramidase Q13510 ASAH1 189 163 18,5 23,5 7 5 0,93 0,92 0,457 0,603 0,91 1,04 0,382 0,652 0,91 1,01 0,387 0,963 Acidic leucine-rich nuclear phosphoprotein 32 family memberP39687 A ANP32A 300 324 21,3 22,1 3 4 1,11 0,367 0,67 0,159 1,05 0,723 Acidic leucine-rich nuclear phosphoprotein 32 family Q92688member B ANP32B 424 221 17,1 20,3 3 4 0,77 0,78 0,439 0,59 0,84 0,606 0,69 0,91 0,539 Aconitate hydratase, mitochondrial Q99798 ACO2 186 15,8 5 1,06 0,734 1,08 0,535 0,95 0,728 Actin, cytoplasmic 1 P60709 ACTB 5 5 69,3 60,8 135 89 0,81 1,00 0,008 0,978 0,75 1,01 0,013 0,876 0,94 1,10 0,313 0,060 Actin-related protein 2 P61160 ACTR2 214 21,6 7 1,13 0,468 0,93 0,842 1,25 0,300 Actin-related protein 2/3 complex subunit 1B O15143 ARPC1B 289 236 22 20,2 5 6 0,94 0,58 0,625 0,012 0,98 0,94 0,783 0,740 1,10 0,86 0,566 0,124 Actin-related protein 2/3 complex subunit 2 O15144 ARPC2 213 24,7 5 1,05 0,877 1,22 0,294 1,12 0,470 Actin-related protein 2/3 complex subunit 3 O15145 ARPC3 504 511 7,3 13,5 2 2 1,27 1,07 0,94 0,86 1,41 1,04 Actin-related protein 2/3 complex subunit 4 P59998 ARPC4 303 660 23,2 12,5 3 1 1,34 0,073 0,86 0,212 0,97 0,781 Actin-related protein 2/3 complex subunit 5 O15511 ARPC5 231 229 28,5 49,7 4 4 0,94 1,02 0,813 0,872 0,98 0,87 0,853 0,402 1,09 1,04 0,684 0,761 Actin-related protein 2/3 complex subunit 5-like proteinQ9BPX5 ARPC5L
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