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Home , 40S ribosomal protein S3, 40S ribosomal protein S7, 40S ribosomal protein S8, 60S ribosomal protein L3, 60S ribosomal protein L6, C1QBP

Table 5. β-arrestin 2-interacting under nonstimulated (-) condition

IPI accession Swiss- Number of Prot symbol name experiments accession number number detected Signal transduction Adaptor proteins IPI00027355 P32121 ARRB2 β-arrestin 2 6 IPI00293857 P49407 ARRB1 β-arrestin 1 6 IPI00021353 P10523 SAG S-arrestin (Retinal S-antigen) (48 kDa protein) (S-AG) (Rod photoreceptor arrestin) 2 IPI00003917 P36575 ARR3 X-arrestin (Arrestin-C) (Cone arrestin) (cArr) (Retinal cone arrestin-3) (C-arrestin) 2 IPI00216318 P31946 YWHAB 14-3-3 β/α (14-3-3 protein beta/alpha) (Protein C inhibitor protein 1) (KCIP-1) (Protein 1054) 2 IPI00220642 P61981 YWHAG 14-3-3 γ (14-3-3 protein gamma) ( C inhibitor protein 1) (KCIP-1) 2 IPI00018146 P27348 YWHAQ 14-3-3 θ (14-3-3 protein tau) (14-3-3 protein theta) (14-3-3 protein T-cell) (HS1 protein) 2 IPI00216319 Q04917 YWHAH 14-3-3 η (14-3-3 protein eta) (Protein AS1) 2 IPI00000816 P62258 YWHAE 14-3-3 ε (14-3-3 protein epsilon) (14-3-3E) 2

Protein IPI00027251 Q15208 STK38 STK38 (Serine/threonine-protein kinase 38) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) 4 SCY1-like 2 (SCY1-like 2 protein) (coated vesicle-associated kinase of 104 kDa) (Eukaryotic protein IPI00396218 Q6P3W7 SCYL2 2 kinase family protein) (CDNA FLJ10074 fis, clone HEMBA1001744, weakly similar to SCY1 IPI00013835 Q13574 DGKZ DGK ζ (Diacylglycerol kinase zeta) ( kinase zeta) (DGK-zeta) (DAG kinase zeta) 2 DGK ε (Diacylglycerol kinase epsilon) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase IPI00003293 P52429 DGKE 2 epsilon) Casein kinase II (casein kinase II alpha 1 subunit) (protein kinase CK2) (CK2 catalytic subunit alpha) IPI00472911 P68400 CSNK2A1 2 (casein kinase II alpha subunit) (casein kinase II-alpha subunit) (Casein kinase II alpha 1 subunit isoform ERK-2 (Mitogen-activated protein kinase 1) (Extracellular signal-regulated kinase 2) (Mitogen-activated IPI00003479 P28482 MAPK1 2 protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) IPI00172636 Q8N553 CAMK2D CaM kinase II delta (Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta) 2 Cell division cycle 2-like protein kinase 5 (CDC2-related protein kinase 5) (Cholinesterase-related cell IPI00029162 Q14004 CDC2L5 2 division controller) IPI00023503 Q00526 CDK3 Cell division protein kinase 3 2 Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal complex IPI00000685 P50613 CDK7 2 kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) IPI00167096 Q8N752 CSNK1A1L CK1 (Casein kinase I isoform alpha-like) (CKI-alpha-like) 2 IPI00163851 Q9P2K8 EIF2AK4 GCN2 eIF2α kinase (Eukaryotic 2-alpha kinase 4) (GCN2-like protein) 2

Phosphatases IPI00020950 P35813 PPM1A PP2Cα (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA) (Protein phosphatase 1A) 3 IPI00026612 O75688 PPM1B PP2Cβ (Protein phosphatase 2C isoform beta) (PP2C-beta) 3 PP2A, subunit A, PR65-α (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha IPI00554737 P30153 PPP2R1A isoform) (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor 2 antigen-associated 61 kDa protein) Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin IPI00183002 O14974 PPP1R12A 2 phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)

Trafficking IPI00216393 P09496 CLTA Clathrin light chain A 2 IPI00216472 P09497 CLTB Clathrin light chain B 2 AP-2 α1 (AP-2 complex subunit alpha-1) (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha- IPI00304577 O95782 AP2A1 adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A 2 large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A AP-2 β1 (AP-2 complex subunit beta-1) (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) IPI00784156 P63010 AP2B1 (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta 2 large chain) (AP105B) Gaf-1 (Rab11 family-interacting protein 5) (Rab11-FIP5) (Rab11-interacting protein Rip11) (Gamma- IPI00022033 Q9BXF6 RAB11FIP5 2 SNAP-associated factor 1) (Phosphoprotein pp75) VPS35 (Vesicle protein sorting 35) (Vacuolar protein sorting-associated protein 35) (hVPS35) (Maternal- IPI00018931 Q96QK1 VPS35 2 embryonic 3) IPI00018452 Q99829 CPNE1 Copine-1 (copine i) 2 AP-3 δ1 (Delta-adaptin) (AP-3 complex subunit delta-1) (Adapter-related protein complex 3 subunit IPI00411453 O14617 AP3D1 3 delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta)

G protein- and small GTPase-related α-Pix (Alpha-Pix) (Rho guanine nucleotide exchange factor 6) (Rac/Cdc42 guanine nucleotide exchange IPI00014256 Q15052 ARHGEF6 2 factor 6) (PAK-interacting exchange factor alpha) (COOL-2) IPI00294879 P46060 RANGAP1 Ran GTPase-activating protein 1 2 IPI00169307 Q8NI19 ARHGAP21 Rho GTPase activating protein 10 2 IPI00179890 Q9UN86 G3BP2 Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain-binding protein 2) (G3BP-2) 2

Other signaling proteins IPI00075248 P62158 CALM1 Calmodulin (CaM) 3 Annexin II (Annexin A2) (Lipocortin II) (Calpactin I heavy chain) (Chromobindin-8) (p36) (Protein I) IPI00455315 P07355 ANXA2 2 (Placental anticoagulant protein IV) (PAP-IV) Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1- IPI00019459 Q15750 TAB1 2 binding protein 1) (TAK1-binding protein 1) I κ-B kinase α (Inhibitor of nuclear factor kappa-B kinase subunit alpha) (I kappa-B kinase alpha) (IkBKA) IPI00005104 O15111 IKKA (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous 2 kinase) (Nuclear factor NF-kappa-B inhibitor IPI00215948 P35221 CTNNA1 Catenin α-1 (Catenin alpha-1) (Cadherin-associated protein) (Alpha E-catenin) (NY- REN-13 antigen) 2 Catenin δ-1 (Catenin delta-1) (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) IPI00182469 O60716 CTNND1 2 (p120(cas)) IPI00414286 O75056 SDC3 Syndecan-3 (SYND3) 2 IPI00018522 Q99873 PRMT1 PRMT1 (Protein arginine N-methyltransferase 1) (Interferon 1-bound protein 4) 2 IPI00646469 Q4G100 WDR26 WDR26 (WDR26 protein) (Myocardial ischemic preconditioning upregulated protein 2) 2

Nucleic acid binding DNA binding, chromatin structure and cell cycle regualtion IPI00217469 Q02539 HIST1H1A Histone H1.1 (H1 histone family, member 1) 2 IPI00021924 Q92522 H1FX Histone H1x 2 IPI00216730 Q8IUE6 HIST2H2AB Histone H2A (Histone H2A type 2-B) 2 Ku70 (ATP-dependent DNA 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) IPI00644712 P12956 XRCC6 (Lupus Ku autoantigen protein p70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) 2 (CTC box- binding factor 75 kDa subunit) (CTCBF) (CTC75) (DNA-repair protein XRCC6) IPI00289601 Q92769 HDAC2 HDAC2 (histone deacetylase 2) (hd2) 2 IPI00152785 P23527 HIST1H2BO Histone H2B (Histone H2B type 1-O) (H2B.n) (H2B/n) (H2B.2) 2 Ku80 (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (Lupus Ku autoantigen protein p86) (Ku86) (Ku80) (86 kDa subunit of Ku antigen) (Thyroid-lupus IPI00220834 P13010 XRCC5 2 autoantigen) (TLAA) (CTC box-binding factor 85 kDa subunit) (CTCBF) (CTC85) (Nuclear factor IV) (DNA-repair protein XRCC5) IPI00292135 Q14739 LBR Lamin-B receptor (Integral nuclear envelope inner ) (LMN2R) 2 MCM3 (DNA replication licensing factor MCM3) (DNA alpha holoenzyme-associated protein IPI00013214 P25205 MCM3 2 P1) (RLF subunit beta) (P102 protein) (P1-MCM3)

Transcription factor and transcription regulatory protein Nopp 140 (Nucleolar phosphoprotein p130) (Nucleolar 130 kDa protein) (140 kDa nucleolar IPI00292387 Q14978 NOLC1 4 phosphoprotein) (Nucleolar and coiled-body phosphoprotein 1) IPI00298696 Q13428 TCOF1 Treacle (Treacher collins franceschetti syndrome 1) 6 JBP1 (Protein arginine N-methyltransferase 5) (Shk1 kinase-binding protein 1 homolog) (SKB1Hs) IPI00441473 O14744 PRMT5 3 (Jak-binding protein 1) (72 kDa ICln-binding protein) IPI00549248 P06748 NPM1 Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin) (Nucleolar protein NO38) 3 IPI00029631 P84090 ERH ERH (Enhancer of rudimentary homolog) 2 TIF 1B (Transcription intermediary factor 1-beta) (TIF1-beta) (Tripartite motif-containing protein 28) IPI00438229 Q13263 TRIM28 (Nuclear corepressor KAP-1) (KRAB- associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) 3 (RING finger protein 96) YB-1 (Y-box transcription factor) (Nuclease sensitive element-binding protein 1) (Y-box-binding IPI00031812 P67809 YBX1 protein 1) (Y-box transcription factor) (CCAAT-binding transcription factor I subunit A) (CBF-A) 2 (Enhancer factor I subunit A) (EFI-A) (DNA-binding protein B) (DBPB) LEO1 (RNA polymerase-associated protein LEO1) (Replicative senescence down- regulated leo1-like IPI00103090 Q8WVC0 LEO1 2 protein) Tho4 (THO complex subunit 4) (Ally of AML-1 and LEF-1) (Transcriptional coactivator Aly/REF) IPI00328840 Q86V81 THOC4 2 (bZIP-enhancing factor BEF) ZNF265 ( protein 265) (Zinc finger Ran-binding domain-containing protein 2) (Zinc IPI00029400 O95218 ZNF265 3 finger, splicing) Trap150 (Thyroid -associated protein 3) (-associated IPI00104050 Q9Y2W1 THRAP3 5 protein complex 150 kDa component) IPI00013788 O43719 HTATSF1 TATSF1 (Tat-SF1) (HIV Tat-specific factor 1) 5 IPI00031960 O95602 POLR1A RPA194 (DNA-directed RNA polymerase I largest subunit) (RNA polymerase I 194 kDa subunit) 3 IPI00026445 Q9H9Y6 POLR1B RPA135 (DNA-directed RNA polymerase I 135 kDa polypeptide) (RNA polymerase I subunit 2) 2 MPP4 (Interleukin enhancer-binding factor 3) (Nuclear factor of activated T- cells 90 kDa) (NF-AT-90) IPI00298788 Q12906 ILF3 (Double-stranded RNA-binding protein 76) (DRBP76) (Translational control protein 80) (TCP80) (Nuclear 2 factor associated with dsRNA) (NFAR) (M-phase phosphoprotein 4) IPI00005477 Q3B726 TWISTNB TWIST neighbor 3 IPI00023860 P55209 NAP1L1 NAP1(hNRP) (Nucleosome assembly protein 1-like 1) (NAP-1-related protein) 2 CSDA protein (Cold shock domain protein A) (DNA-binding protein A) (Cold shock domain-containing IPI00031801 P16989 CSDA 2 protein A) (Single-strand DNA-binding protein NF-GMB)

RNA processing and ribonucleoprotein Nop10 (H/ACA ribonucleoprotein complex subunit 3) (Nucleolar A member 3) IPI00032853 Q9NPE3 NOLA3 2 (snoRNP protein NOP10) IPI00549342 Q5JRR2 RBM10 RNA binding motif protein 10 4 IPI00604620 P19338 NCL Nucleolin (Protein C23) 3 IPI00411937 O00567 NOL5A Nop56 (Nucleolar protein Nop56) (Nucleolar protein 5A) 2 SAP155 (Splicing factor 3B subunit 1) (Spliceosome-associated protein 155) (SF3b155) (Pre-mRNA- IPI00026089 O75533 SF3B1 3 splicing factor SF3b 155 kDa subunit) SAP 145 (Splicing factor 3B subunit 2) (Spliceosome-associated protein 145) (SF3b150) (Pre- IPI00221106 Q13435 SF3B2 2 mRNA-splicing factor SF3b 145 kDa subunit) PSF (Splicing factor, proline-and glutamine-rich) (Polypyrimidine tract- binding protein-associated-splicing IPI00010740 P23246 SFPQ factor) (PTB-associated-splicing factor) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa 2 DNA-pairing protein) (hPOMp100) NONO protein (Non-POU domain-containing octamer-binding protein) (NonO protein) (54 kDa nuclear IPI00304596 Q15233 NONO RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding 2 p52/p100 complex, 52 kDa subunit) DDX3 (ATP-dependent RNA helicase DDX3X) (DEAD box protein 3, X- chromosomal) (Helicase-like IPI00215637 O00571 DDX3X 2 protein 2) (HLP2) (DEAD box, X isoform) DDX15 (Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15) (DEAH box protein 15) IPI00396435 O43143 DHX15 3 (ATP-dependent RNA helicase #46) SRRM2 (splicing coactivator subunit SRm300) (Serine/arginine repetitive matrix protein 2) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related IPI00782992 Q9UQ35 SRRM2 2 nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (300 kDa nuclear matrix antigen) SMD1 (Sm-D1) (Small nuclear ribonucleoprotein Sm D1) (snRNP core protein D1) (Sm-D IPI00302850 P62314 SNRPD1 4 autoantigen) IPI00017963 P62316 SNRPD2 SMD2 (Small nuclear ribonucleoprotein Sm D2) (snRNP core protein D2) (Sm-D2) 2 hnRNP A1 (hnRNP core protein A1) (Heterogeneous nuclear ribonucleoprotein A1) (Helix- IPI00465365 P09651 HNRPA1 3 destabilizing protein) (Single-strand RNA-binding protein) IPI00386854 Q9BWA9 HNRPA2B1 hnRNP A2 (HNRPA2B1 protein) (heterogeneous nuclear ribonucleoprotein A2/B1) 2 IPI00028888 Q14103 HNRPD hnRNP D0 (Heterogeneous nuclear ribonucleoprotein D0) (AU-rich element RNA-binding protein 1) 3 IPI00013881 P31943 HNRPH1 hnRNP H (Heterogeneous nuclear ribonucleoprotein H1) 3 hnRNP K (Heterogeneous nuclear ribonucleoprotein K) (Transformation up-regulated nuclear IPI00216049 P61978 HNRPK 4 protein) (TUNP) IPI00171903 P52272 HNRPM hnRNP M (Heterogeneous nuclear ribonucleoprotein M) 3 hnRNP U (Heterogeneous nuclear ribonucleoprotein U) (Scaffold attachment factor A) (SAF-A) IPI00025054 Q00839 HNRPU 4 (p120) (pp120) IPI00011913 Q13151 HNRPA0 hnRNP A0 (Heterogeneous nuclear ribonucleoprotein A0) 2 IPI00216592 P07910 HNRPC hnRNP C (Heterogeneous nuclear ribonucleoproteins C1/C2) (hnRNP C1 / hnRNP C2) 2 IPI00003881 P52597 HNRPF hnRNP F (Heterogeneous nuclear ribonucleoprotein F) (Nucleolin-like protein mcs94-1) 2 IPI00026230 P55795 HNRPH2 hnRNP H' (Heterogeneous nuclear ribonucleoprotein H') (FTP-3) 2 hnRNP I (Polypyrimidine tract-binding protein 1) (PTB) (Heterogeneous nuclear ribonucleoprotein I) (57 IPI00179964 P26599 PTBP1 2 kDa RNA-binding protein PPTB-1) IPI00012074 O43390 hnRPR hnRNP R (Heterogeneous nuclear ribonucleoprotein R) 3 SAP 130 (Splicing factor 3B subunit 3) (Spliceosome-associated protein 130) (SF3b130) (Pre-mRNA- IPI00300371 Q15393 SF3B3 2 splicing factor SF3b 130 kDa subunit) (STAF130) Dyskerin (H/ACA ribonucleoprotein complex subunit 4) (Dyskerin) (Nopp140-associated protein of IPI00221394 O60832 DKC1 3 57 kDa) IPI00025039 P22087 FBL Fibrillarin (rRNA 2'-O-methyltransferase fibrillarin) (34 kDa nucleolar scleroderma antigen) 2 U5-116 kDa (hSNU114) (116 kDa U5 small nuclear ribonucleoprotein component) (U5 snRNP-specific IPI00003519 Q15029 EFTUD2 2 protein, 116 kDa) ( Tu GTP-binding domain protein 2) PABP3 (Polyadenylate-binding protein 3) (Poly(A)-binding protein 3) (PABP 3) (Testis-specific poly(A)- IPI00301154 Q9H361 PABPC3 2 binding protein) PABP4 (Polyadenylate-binding protein 4) (Poly(A)-binding protein 4) (PABP 4) (Inducible poly(A)-binding IPI00012726 Q13310 PABPC4 2 protein) (iPABP) (Activated-platelet protein 1) (APP-1) PAI-RBP1 (SERPINE1 mRNA binding protein 1) (Plasminogen activator inhibitor 1 RNA-binding protein) IPI00410693 Q8NC51 SERBP1 3 (PAI1 RNA- binding protein 1)

Protein biosynthesis IPI00012079 P23588 EIF4B eIF-4B ( initiation factor 4B) 5 IPI00014424 Q05639 EEF1A2 eEF1A-2 (Elongation factor 1-alpha 2) (EF-1-alpha-2) (Elongation factor 1 A-2) (Statin S1) 3 IPI00008524 P11940 PABPC1 PABP1 (Polyadenylate-binding protein 1) (PABP) (Poly(A)-binding protein 1) (PABP 1) 2 IGF-II mRNA-binding protein 1 (-like growth factor 2 mRNA binding protein 1) (MRNA-binding IPI00008557 Q9NZI8 IGF2BP1 2 protein CRDBP) IPI00419880 P61247 RPS3A S3a (40S ribosomal protein S3a) 3 IPI00011253 P23396 RPS3 Ribosomal protein S3 () 2 IPI00221093 P08708 RPS17 Ribosomal protein S17 (40S ribosomal protein S17) 2 IPI00215780 P39019 RPS19 Ribosomal protein S19 (40S ribosomal protein S19) 2 IPI00299573 P62424 RPL7A Ribosomal protein L7a (60S ribosomal protein L7a) 2 IPI00030179 P18124 RPL7 Ribosomal protein L7 () 2 IPI00024933 P30050 RPL12 Ribosomal protein L12 (60S ribosomal protein L12) 2 IPI00215719 Q07020 RPL18 Ribosomal protein L18 (60S ribosomal protein L18) 2 IPI00247583 P46778 RPL21 Ribosomal protein L21 (60S ribosomal protein L21) 2 Ribosomal protein L22 (60S ribosomal protein L22) (Epstein-Barr virus small RNA-associated IPI00219153 P35268 RPL22 2 protein) (EBER-associated protein) (EAP) (Heparin-binding protein HBp15) IPI00026302 P62899 RPL31 Ribosomal protein L31 (60S ribosomal protein L31) 2 IPI00008530 P05388 RPLP0 Ribosomal protein P0 (60S acidic ribosomal protein P0) 2 IPI00008527 P05386 RPLP1 Ribosomal protein P1 (60S acidic ribosomal protein P1) 2 IPI00008529 P05387 RPLP2 Ribosomal protein P2 (60S acidic ribosomal protein P2) 2 IPI00021840 P62753 RPS6 (40S ribosomal protein S6) (Phosphoprotein NP33) 3 IPI00013415 P62081 RPS7 Ribosomal protein S7 () 2 IPI00216587 P62241 RPS8 Ribosomal protein S8 () 2 IPI00221089 P62277 RPS13 Ribosomal protein S13 (40S ribosomal protein S13) 2 IPI00550021 P39023 RPL3 Ribosomal protein L3 () 3 Ribosomal protein L6 () (TAX-responsive enhancer element-binding IPI00741742 Q8TBK5 RPL6 2 protein 107) (TAXREB107) (Neoplasm-related protein C140) IPI00002821 P50914 RPL14 Ribosomal protein L14 (60S ribosomal protein L14) 2 IPI00470528 P61313 RPL15 Ribosomal protein L15 (60S ribosomal protein L15) 2 IPI00182533 P46779 RPL28 Ribosomal protein L28 (60S ribosomal protein L28) 2 IPI00186290 P13639 EEF2 EF-2 (Elongation factor 2) 2

Cellular organization Cytoskeleton constituent proteins IPI00021439 P60709 ACTB Actin β (Actin beta) (Actin, cytoplasmic 1) 4 Tubulin α-1 (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha- tubulin) (Tubulin H2- IPI00007750 P68366 TUBA1 4 alpha) IPI00179709 Q13748 TUBA2 Tubulin α-2 (Tubulin alpha-2 chain) (Alpha-tubulin 2) 3 IPI00218343 Q9BQE3 TUBA6 Tubulin α-6 (Tubulin alpha-6 chain) (Alpha-tubulin 6) 4 IPI00013475 Q13885 TUBB2 Tubulin β-2A (Tubulin beta-2A chain) 3 IPI00007752 P68371 TUBB2C Tubulin β-2 (Tubulin beta-2C chain) (Tubulin beta-2 chain) 5 IPI00013683 Q13509 TUBB3 Tubulin β-3 (Tubulin beta-3 chain) (Tubulin beta-4) 3 IPI00418471 P08670 VIM Vimentin 3 Actin γ-2 (Gamma-2-actin) (Actin, gamma-enteric smooth muscle) (Smooth muscle gamma actin) (Alpha- IPI00025416 P63267 ACTG2 4 actin-3) IPI00023598 P04350 TUBB4 Tubulin β-4 (Tubulin beta-4 chain) (Tubulin 5 beta) 3 IPI00180675 Q71U36 TUBA3 Tubulin α-3 (Tubulin alpha-3 chain) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin, alpha, brain-specific) 2 IPI00646909 Q9NY65 TUBA8 Tubulin α-8 (Tubulin alpha-8 chain) (Alpha-tubulin 8) 2

Cytoskeleton accessory proteins IPI00012011 P23528 CFL1 Cofilin-1 (Cofilin, non-muscle isoform) (18 kDa phosphoprotein) (p18) 2 Filamin A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) IPI00333541 P21333 FLNA 4 (ABP-280) (Nonmuscle filamin) IPI00026314 P06396 GSN Gelsolin (Actin-depolymerizing factor) (ADF) (Brevin) (AGEL) 3 IPI00005087 Q9NYL9 TMOD3 Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) 2 IPI00413728 Q13813 SPTAN1 α-fodrin (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain) 2 IPI00414554 Q9BPX5 ARPC5L ARC16-2 (Actin related protein 2/3 complex, subunit 5-like) 2 β-fodrin (spectrin, beta, non-erythrocytic 1) (beta-fodrin) (beta-spectrin) (beta-G spectrin) (beta-spectrin 2) IPI00333015 Q8IX99 SPTBN1 2 (beta-spectrin II) (beta-spectrin, general form) (embryonic liver beta-fodrin) IPI00008918 Q9UHB6 LIMA1 Eplin (Epithelial protein lost in neoplasm) (LIM domain and actin-binding protein 1) 3 IPI00008868 P46821 MAP1B MAP 1B (Microtubule-associated protein 1B) 4 IPI00005969 P52907 CAPZA1 CapZ α-1 (CapZ alpha-1) (F-actin capping protein alpha-1 subunit) 4 IPI00026182 P47755 CAPZA2 CapZ α-2 (CapZ alpha-2) (F-actin capping protein alpha-2 subunit) 2 IPI00029601 Q14247 CTTN Cortactin (Src substrate cortactin) (Amplaxin) (Oncogene EMS1) 2 IPI00003406 Q16643 DBN1 Drebrin (Developmentally-regulated brain protein) 2

Motor proteins Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) IPI00019502 P35579 MYH9 5 (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC- IPI00010418 O00159 MYO1C Myosin Ic (Myosin I beta) (MMI-beta) (MMIb) 2 Myosin light chain (MYL6 protein) (Myosin light polypeptide 6) (Smooth muscle and nonmuscle IPI00335168 P60660 MYL6 2 myosin light chain alkali 6) (Myosin light chain alkali 3) (Myosin light chain 3) (MLC-3) (LC17) Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain IPI00456969 Q14204 DYNC1H1 2 1, cytoplasmic 1) Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) IPI00397526 P35580 MYH10 2 (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B)

Metabolic PK3 ( 3) (Pyruvate kinase M 2) (Pyruvate kinase isozymes M1/M2) (Pyruvate kinase IPI00383237 P14618 PKM2 muscle isozyme) (Pyruvate kinase 2/3) (Cytosolic thyroid hormone-binding protein) (CTHBP) 4 (THBP1) IPI00219018 P04406 GAPDH GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) 2 IPI00026781 P49327 FASN Fatty acid synthase 2 iPFK-2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) (6PF-2-K/Fru- 2,6-P2ASE IPI00004511 Q16875 PFKFB3 2 brain/placenta-type isozyme) (NY-REN-56 antigen) Protein disulfide- precursor (PDI) (Prolyl 4- hydroxylase subunit beta) (Cellular thyroid IPI00010796 P07237 P4HB 2 hormone-binding protein) (p55) SDH2 (Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor) (Fp) IPI00305166 P31040 SDHA 2 (Flavoprotein subunit of complex II) Ribophorin II (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit precursor) IPI00301271 P04844 RPN2 2 (RPN-II) (RIBIIR) IPI00013184 P41227 ARD1A ARD1 (N-terminal acetyltransferase complex ARD1 subunit homolog A) 2 IPI00290142 P17812 CTPS CTP synthase (CTP synthase 1) (UTP--ammonia 1) (CTP synthetase 1) 2 DDX1 (ATP-dependent RNA helicase DDX1) (DEAD box protein 1) (DEAD box protein retinoblastoma) IPI00293655 Q92499 DDX1 2 (DBP-RB)

Chaperone and stress response IPI00003865 P11142 HSPA8 HSC70 (Heat shock cognate 71 kDa protein) (Heat shock 70 kDa protein 8) 4 IPI00304925 P08107 HSP70 HSP70.1 (Heat shock 70 kDa protein 1) (HSP70-1/HSP70-2) 3 HSP70-Hom (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-like) (Heat shock 70 kDa IPI00301277 P34931 HSPA1L 2 protein 1-Hom) IPI00414676 P08238 HSP90B HSP90 (Heat shock protein HSP 90-beta) (HSP 84) 2 T-complex protein 1ζ (T-complex protein 1 subunit zeta) (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1) (Tcp20) IPI00027626 P40227 CCT6A 2 (HTR3) (Acute morphine dependence-related protein 2)

Ion channels Chloride channel, nucleotide sensitive 1A (Methylosome subunit pICln) (Chloride conductance regulatory IPI00004795 P54105 CLNS1A protein ICln) (I(Cln)) (Chloride channel, nucleotide sensitive 1A) (Chloride ion current inducer protein) 2 (ClCI) (Reticulocyte pICln) IPI00221124 Q14722 KCNAB1 Kv-beta-1 (Voltage-gated potassium channel subunit b-1) (K(+) channel subunit beta-1) 2 TrpV4 (Transient receptor potential cation channel subfamily V member 4) (osm-9-like TRP channel 4) IPI00168624 Q9HBA0 TRPV4 (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid 2 receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) Chloride intracellular channel protein 1 (Nuclear chloride ion channel 27) (NCC27) (Chloride channel IPI00010896 O00299 CLIC1 2 ABP) (Regulatory nuclear chloride ion channel protein) (hRNCC)

Miscellaneous Apoptosis IPI00006079 Q9NYF8 BCLAF1 BTF (Bcl-2-associated transcription factor 1) (Btf) 3 BIP (78 kDa glucose-regulated protein precursor) (GRP 78) (Heat shock 70 kDa protein 5) IPI00003362 P11021 HSPA5 (Immunoglobulin heavy chain-binding protein) (BiP) (Endoplasmic reticulum lumenal Ca(2+)- 3 binding protein grp78)

Proteolysis and ubiquitination IPI00179330 Q5RKT7 RPS27A Ubiquitin and ribosomal protein S27a 3 IPI00719280 Q5U5U6 UBB Ubiquitin B 3 IPI00784990 Q5UGI3 UBC Ubiquitin C 2 Calpain-1 catalytic subunit (Calpain-1 large subunit) (Calcium-activated neutral proteinase 1) (CANP 1) IPI00011285 P07384 CAPN1 2 (Calpain mu-type) (muCANP) (Micromolar-calpain) IPI00456429 Q3MIH3 UBA52 CEP52 (Ubiquitin and ribosomal protein L40 precursor) (60S ribosomal protein L40) 2 EDD1 (Ubiquitin-protein ligase EDD1) (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) IPI00026320 O95071 EDD1 2 (Progestin-induced protein)

Others IPI00550655 Q9Y657 SPIN Spindlin-1 (Ovarian cancer-related protein) 2 IPI00174535 Q5JUX0 SPIN3 Spindlin-3 (Spindlin-like protein 3) (SPIN-3) 2 IPI00295022 P30414 NKTR NK-TR protein (NK-tumor recognition protein) (Natural-killer cells cyclophilin-related protein) 2 IPI00027547 P81605 DCD Dermcidin (Dermcidin precursor) (Preproteolysin) 2 p33 (Complement component C1q binding protein) (Complement component 1 Q subcomponent-binding IPI00014230 Q07021 C1QBP protein, mitochondrial precursor) (Glycoprotein gC1qBP) (C1qBP) (GC1q-R protein) (Hyaluronan- binding 2 protein 1) (Mitochondrial matrix protein p32) IPI00384397 Q9UL80 Myosin-reactive immunoglobulin light chain variable region 4 IPI00419424 Q6PIH6 IGKV1-5 protein 2

Unknown IPI00012202 Q9BQA1 WDR77 Methylosome protein 50 3 IPI00003269 Hypothetical protein LOC345651 4 IPI00419322 Q7Z4V5 HDGF2 HDGF2 (Hepatoma-derived growth factor 2) (HGDF-related pro 2) 2 IPI00301434 Q9H3K6 BOLA2 BolA-like protein 2 (BolA-like protein My016) 2 Mob4B protein (Mps one binder kinase activator-like 1B (Mob1 homolog 1B) (Mob1 alpha) (Mob1A) IPI00301518 Q9H8S9 MOBK1B (Protein Mob4B) PREDICTED: similar to FKSG30 (PREDICTED: similar to Prostate, ovary, testis expressed protein IPI00401614 3 on 2 ) Hypothetical protein FLJ10100 (CDNA FLJ10100 FIS, CLONE HEMBA1002469, MODERATELY IPI00029969 Q9NWD7 2 SIMILAR TO DXS8237E PROTEIN) IPI00413922 11 kDa protein 2 IPI00455475 PREDICTED: similar to cytoskeletal β actin 3 IPI00444605 Q6ZSQ4 Hypothetical protein FLJ45296 3 IPI00157721 46 kDa protein 3 IPI00479481 61 kDa protein 3 IPI00478731 29 kDa protein 2 IPI00106955 Hypothetical protein LOC144097 3 TTP1 (Hypothetical protein) ( open 79, isoform CRA_c) (Chromosome 17 IPI00161600 Q9NQ92 2 open reading frame 79)