Table 5. β-arrestin 2-interacting proteins under nonstimulated (-) condition IPI accession Swiss- Number of Prot Gene symbol Protein name experiments accession number number detected Signal transduction Adaptor proteins IPI00027355 P32121 ARRB2 β-arrestin 2 6 IPI00293857 P49407 ARRB1 β-arrestin 1 6 IPI00021353 P10523 SAG S-arrestin (Retinal S-antigen) (48 kDa protein) (S-AG) (Rod photoreceptor arrestin) 2 IPI00003917 P36575 ARR3 X-arrestin (Arrestin-C) (Cone arrestin) (cArr) (Retinal cone arrestin-3) (C-arrestin) 2 IPI00216318 P31946 YWHAB 14-3-3 β/α (14-3-3 protein beta/alpha) (Protein kinase C inhibitor protein 1) (KCIP-1) (Protein 1054) 2 IPI00220642 P61981 YWHAG 14-3-3 γ (14-3-3 protein gamma) (Protein kinase C inhibitor protein 1) (KCIP-1) 2 IPI00018146 P27348 YWHAQ 14-3-3 θ (14-3-3 protein tau) (14-3-3 protein theta) (14-3-3 protein T-cell) (HS1 protein) 2 IPI00216319 Q04917 YWHAH 14-3-3 η (14-3-3 protein eta) (Protein AS1) 2 IPI00000816 P62258 YWHAE 14-3-3 ε (14-3-3 protein epsilon) (14-3-3E) 2 Protein kinases IPI00027251 Q15208 STK38 STK38 (Serine/threonine-protein kinase 38) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) 4 SCY1-like 2 (SCY1-like 2 protein) (coated vesicle-associated kinase of 104 kDa) (Eukaryotic protein IPI00396218 Q6P3W7 SCYL2 2 kinase family protein) (CDNA FLJ10074 fis, clone HEMBA1001744, weakly similar to SCY1 IPI00013835 Q13574 DGKZ DGK ζ (Diacylglycerol kinase zeta) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta) 2 DGK ε (Diacylglycerol kinase epsilon) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase IPI00003293 P52429 DGKE 2 epsilon) Casein kinase II (casein kinase II alpha 1 subunit) (protein kinase CK2) (CK2 catalytic subunit alpha) IPI00472911 P68400 CSNK2A1 2 (casein kinase II alpha subunit) (casein kinase II-alpha subunit) (Casein kinase II alpha 1 subunit isoform ERK-2 (Mitogen-activated protein kinase 1) (Extracellular signal-regulated kinase 2) (Mitogen-activated IPI00003479 P28482 MAPK1 2 protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) IPI00172636 Q8N553 CAMK2D CaM kinase II delta (Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta) 2 Cell division cycle 2-like protein kinase 5 (CDC2-related protein kinase 5) (Cholinesterase-related cell IPI00029162 Q14004 CDC2L5 2 division controller) IPI00023503 Q00526 CDK3 Cell division protein kinase 3 2 Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex IPI00000685 P50613 CDK7 2 kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) IPI00167096 Q8N752 CSNK1A1L CK1 (Casein kinase I isoform alpha-like) (CKI-alpha-like) 2 IPI00163851 Q9P2K8 EIF2AK4 GCN2 eIF2α kinase (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) 2 Phosphatases IPI00020950 P35813 PPM1A PP2Cα (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA) (Protein phosphatase 1A) 3 IPI00026612 O75688 PPM1B PP2Cβ (Protein phosphatase 2C isoform beta) (PP2C-beta) 3 PP2A, subunit A, PR65-α (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha IPI00554737 P30153 PPP2R1A isoform) (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor 2 antigen-associated 61 kDa protein) Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin IPI00183002 O14974 PPP1R12A 2 phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Trafficking IPI00216393 P09496 CLTA Clathrin light chain A 2 IPI00216472 P09497 CLTB Clathrin light chain B 2 AP-2 α1 (AP-2 complex subunit alpha-1) (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha- IPI00304577 O95782 AP2A1 adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A 2 large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A AP-2 β1 (AP-2 complex subunit beta-1) (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) IPI00784156 P63010 AP2B1 (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta 2 large chain) (AP105B) Gaf-1 (Rab11 family-interacting protein 5) (Rab11-FIP5) (Rab11-interacting protein Rip11) (Gamma- IPI00022033 Q9BXF6 RAB11FIP5 2 SNAP-associated factor 1) (Phosphoprotein pp75) VPS35 (Vesicle protein sorting 35) (Vacuolar protein sorting-associated protein 35) (hVPS35) (Maternal- IPI00018931 Q96QK1 VPS35 2 embryonic 3) IPI00018452 Q99829 CPNE1 Copine-1 (copine i) 2 AP-3 δ1 (Delta-adaptin) (AP-3 complex subunit delta-1) (Adapter-related protein complex 3 subunit IPI00411453 O14617 AP3D1 3 delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) G protein- and small GTPase-related α-Pix (Alpha-Pix) (Rho guanine nucleotide exchange factor 6) (Rac/Cdc42 guanine nucleotide exchange IPI00014256 Q15052 ARHGEF6 2 factor 6) (PAK-interacting exchange factor alpha) (COOL-2) IPI00294879 P46060 RANGAP1 Ran GTPase-activating protein 1 2 IPI00169307 Q8NI19 ARHGAP21 Rho GTPase activating protein 10 2 IPI00179890 Q9UN86 G3BP2 Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain-binding protein 2) (G3BP-2) 2 Other signaling proteins IPI00075248 P62158 CALM1 Calmodulin (CaM) 3 Annexin II (Annexin A2) (Lipocortin II) (Calpactin I heavy chain) (Chromobindin-8) (p36) (Protein I) IPI00455315 P07355 ANXA2 2 (Placental anticoagulant protein IV) (PAP-IV) Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1- IPI00019459 Q15750 TAB1 2 binding protein 1) (TAK1-binding protein 1) I κ-B kinase α (Inhibitor of nuclear factor kappa-B kinase subunit alpha) (I kappa-B kinase alpha) (IkBKA) IPI00005104 O15111 IKKA (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous 2 kinase) (Nuclear factor NF-kappa-B inhibitor IPI00215948 P35221 CTNNA1 Catenin α-1 (Catenin alpha-1) (Cadherin-associated protein) (Alpha E-catenin) (NY- REN-13 antigen) 2 Catenin δ-1 (Catenin delta-1) (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) IPI00182469 O60716 CTNND1 2 (p120(cas)) IPI00414286 O75056 SDC3 Syndecan-3 (SYND3) 2 IPI00018522 Q99873 PRMT1 PRMT1 (Protein arginine N-methyltransferase 1) (Interferon receptor 1-bound protein 4) 2 IPI00646469 Q4G100 WDR26 WDR26 (WDR26 protein) (Myocardial ischemic preconditioning upregulated protein 2) 2 Nucleic acid binding DNA binding, chromatin structure and cell cycle regualtion IPI00217469 Q02539 HIST1H1A Histone H1.1 (H1 histone family, member 1) 2 IPI00021924 Q92522 H1FX Histone H1x 2 IPI00216730 Q8IUE6 HIST2H2AB Histone H2A (Histone H2A type 2-B) 2 Ku70 (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) IPI00644712 P12956 XRCC6 (Lupus Ku autoantigen protein p70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) 2 (CTC box- binding factor 75 kDa subunit) (CTCBF) (CTC75) (DNA-repair protein XRCC6) IPI00289601 Q92769 HDAC2 HDAC2 (histone deacetylase 2) (hd2) 2 IPI00152785 P23527 HIST1H2BO Histone H2B (Histone H2B type 1-O) (H2B.n) (H2B/n) (H2B.2) 2 Ku80 (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (Lupus Ku autoantigen protein p86) (Ku86) (Ku80) (86 kDa subunit of Ku antigen) (Thyroid-lupus IPI00220834 P13010 XRCC5 2 autoantigen) (TLAA) (CTC box-binding factor 85 kDa subunit) (CTCBF) (CTC85) (Nuclear factor IV) (DNA-repair protein XRCC5) IPI00292135 Q14739 LBR Lamin-B receptor (Integral nuclear envelope inner membrane protein) (LMN2R) 2 MCM3 (DNA replication licensing factor MCM3) (DNA polymerase alpha holoenzyme-associated protein IPI00013214 P25205 MCM3 2 P1) (RLF subunit beta) (P102 protein) (P1-MCM3) Transcription factor and transcription regulatory protein Nopp 140 (Nucleolar phosphoprotein p130) (Nucleolar 130 kDa protein) (140 kDa nucleolar IPI00292387 Q14978 NOLC1 4 phosphoprotein) (Nucleolar and coiled-body phosphoprotein 1) IPI00298696 Q13428 TCOF1 Treacle (Treacher collins franceschetti syndrome 1) 6 JBP1 (Protein arginine N-methyltransferase 5) (Shk1 kinase-binding protein 1 homolog) (SKB1Hs) IPI00441473 O14744 PRMT5 3 (Jak-binding protein 1) (72 kDa ICln-binding protein) IPI00549248 P06748 NPM1 Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin) (Nucleolar protein NO38) 3 IPI00029631 P84090 ERH ERH (Enhancer of rudimentary homolog) 2 TIF 1B (Transcription intermediary factor 1-beta) (TIF1-beta) (Tripartite motif-containing protein 28) IPI00438229 Q13263 TRIM28 (Nuclear corepressor KAP-1) (KRAB- associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) 3 (RING finger protein 96) YB-1 (Y-box transcription factor) (Nuclease sensitive element-binding protein 1) (Y-box-binding IPI00031812 P67809 YBX1 protein 1) (Y-box transcription factor) (CCAAT-binding transcription factor I subunit A) (CBF-A) 2 (Enhancer factor I subunit A) (EFI-A) (DNA-binding protein B) (DBPB) LEO1 (RNA polymerase-associated protein LEO1) (Replicative senescence down- regulated leo1-like IPI00103090 Q8WVC0 LEO1 2 protein) Tho4 (THO complex subunit 4) (Ally of AML-1 and LEF-1) (Transcriptional coactivator Aly/REF) IPI00328840 Q86V81 THOC4 2 (bZIP-enhancing factor BEF) ZNF265 (Zinc finger protein 265) (Zinc finger Ran-binding domain-containing protein 2) (Zinc IPI00029400 O95218 ZNF265 3 finger, splicing) Trap150 (Thyroid hormone receptor-associated protein 3) (Thyroid hormone receptor-associated IPI00104050 Q9Y2W1 THRAP3 5 protein complex 150 kDa component) IPI00013788 O43719 HTATSF1 TATSF1 (Tat-SF1) (HIV Tat-specific factor 1) 5 IPI00031960 O95602 POLR1A RPA194