Effect of Β-Oxidation Stimulant Against Metabolic Syndrome of Saccharin in Rat: a Behavioral, Biochemical, and Histological Study
Journal of Applied Pharmaceutical Science Vol. 11(01), pp 061-071, January, 2021 Available online at http://www.japsonline.com DOI: 10.7324/JAPS.2021.110106 ISSN 2231-3354 Effect of β-oxidation stimulant against metabolic syndrome of saccharin in rat: A behavioral, biochemical, and histological study Kadry Abd-El kader Moktar El-bakry1, Mohammad Hamed Bahnasawy Ayesh2, Hekmat Lotfy El-Gammal3, Omar Abdel- Hamed Ahmed-Farid4*, Barga Abou-khzam farag Abou-khzam2 1Zoology Department, Faculty of Science, Damietta University, Damietta, Egypt. 2Experimental Embryos Department, Faculty of Science, Damietta University, Damietta, Egypt. 3Physiology Department, NODCAR, Giza, Egypt. 4Physiology, Zoology Department, Faculty of Science, Sebha University, Sebha, Libya. ARTICLE INFO ABSTRACT Received on: 18/05/2020 Introduction: Saccharin (Sac) is a sweetener that is still regarded as a carcinogen and diabetic inducer in some parts of Accepted on: 21/10/2020 the world. In the current study, we explored the effects of coenzyme Q10 (COQ10) against saccharin on brain metabolic Available online: 05/01/2021 syndrome. Methods: A total of 108 adult male rats were divided into two experiments. The first experiment assessed the lethal dose 50 (LD ) of saccharin (12.5, 15, 17.5, 20, 22.5, and 25 g/kg b.wt). Forty-eight rats were divided into six groups, Key words: 50 which contained eight rats each. In the second experiment, 60 rats were divided into six groups (10 rats/each). Groups Neuroprotective, saccharin, included the following: control group (G1), COQ10 20 mg/kg b.wt treatment group (G2), Sac 1/10 LD50 treatment coenzyme Q10, rats. group (G3), Sac 1/20 LD50 treatment group (G4), Sac 1/10 LD50 plus COQ10 treatment group (G5), and Sac 1/20 LD50 plus COQ10 treatment group (G6).
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