(12) United States Patent (10) Patent No.: US 8.420,892 B2
USOO8420892B2 (12) UnitedO States Patent (10) Patent No.: US 8.420,892 B2 Damude et al. (45) Date of Patent: *Apr. 16, 2013 (54) DELTA-9 ELONGASES AND THEIR USE IN WO WOOOf 12720 3, 2000 MAKING POLYUNSATURATED FATTY WO WOOO,34439 6, 2000 ACDS WO WOO2,26946 4/2002 WO WOO2/O77213 10, 2002 WO WO2004/057 001 T 2004 (75) Inventors: Howard Glenn Damude, Hockessin, WO WO2004/0711.78 8, 2004 DE (US); Brian McGonigle, WO WO2004/071467 8, 2004 Wilmington, DE (US); Quinn Qun Zhu, WO WO2004/090123 10, 2004 West Chester, PA (US); Zhixiong Xue, W. W39:23 3. Chadds Ford, PA (US) (73) Assignee: E. I. du Pont de Nemours and OTHER PUBLICATIONS Company, Wilmington, DE (US) Browse et al., Trends in Biochemical Sciences, Polyunsaturated fatty c - r b disclai h f thi acid synthesis: what will they think of next? vol. 27(9), pp. 467-473, (*) Notice: Su ject to any disc almer, the term. OthS 2002. patent is extended or adjusted under 35 Napier, Trends in Plant Sciences, Plumbing the depths of PUFA U.S.C. 154(b) by 161 days. biosynthesis: a novel polyketide synthase-like pathway from marine This patent is Subject to a terminal dis- organisms, vol. 7(2), pp. 51-54, 2002. M claimer Spychalla et al., Proc. Natl. Acad. Sci. USA. Identification of an animal W-3 fatty acid desaturase by heterologous expression in Arabidopsis, vol. 94, pp. 1142-1147, 1997. (21) Appl. No.: 12/725,482 National Center for Biotechnology Information General Identifier 1-1. No. 17226123, Accession No.
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