PRODUCT DATA SHEET Bioworld Technology,Inc.

CCRL1 polyclonal antibody

Catalog: BS61526 Host: Rabbit Reactivity: Human,Mouse,Rat

BackGround: Applications: Atypical receptor that controls chemokine WB: 1:500~1:1000 levels and localization via high-affinity chemokine bind- Storage&Stability: ing that is uncoupled from classic ligand-driven signal Store at 4°C short term. Aliquot and store at -20°C long transduction cascades, resulting instead in chemokine se- term. Avoid freeze-thaw cycles. questration, degradation, or transcytosis. Also known as Specificity: interceptor (internalizing receptor) or chemo- CCRL1 polyclonal antibody detects endogenous levels of kine-scavenging receptor or chemokine decoy receptor. CCRL1 . Acts as a receptor for CCL2, CCL8, CCL13, DATA: CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to lig- and internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through in- ternalization. Negatively regulates CXCR3-induced Western blot (WB) analysis of CCRL1 polyclonal antibody at 1:500 di- chemotaxis. Regulates T-cell development in the thymus. lution Product: Lane1:Hela whole cell lysate(40ug) Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, Lane2:HEK293T whole cell lysate(40ug) 50% glycerol, pH7.2 Lane3:L02 whole cell lysate(40ug) Molecular Weight: Lane4:The heart tissue lysate of Mouse(40ug) ~ 40 kDa Lane5:The heart tissue lysate of Rat(40ug) Swiss-Prot: Note: Q9NPB9 For research use only, not for use in diagnostic procedure. Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific im- munogen and the purity is > 96% (by SDS-PAGE).

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