The Editor of the Journal of Pharmacology & Experimental Therapeutics wishes to express appreciation to the following colleagues who acted as Guest Editors for Specific Fields in 1987.

Martin W. Adler Frank R. Goodman Elaine Sanders-Bush Lewis Aronow Robert Z. Gussin Lewis E. Seiden C. Paul Bianchi Conan Kornetsky Theodore J. Torphy Allan H. Conney Donald J. Jenden John L. Skosey Theodore J. Cicero Robert M. Joy Larry G. Stark Charles R. Craig Louis Lemberger Norman Weiner Gerard L. Gebber Benedict R. Lucchesi Wallace D. Winters James W. Gibb Donald V. Priola Dixon M. Woodbury Dora B. Goldstein

Additionally, sincere thanks are due to 724 of our colleagues not on the Editorial Advisory Board who reviewed articles for the Journal in 1987. Their contributions are acknowledged individually in the Annual Report of The Journal to The Board of Publications Trustees of The American Society for Pharmacology and Experimental Therapeutics. INDEX

Volume 245, April-June, 1988

A23187, effect ofextracellularcalcium omis- classification, ligand affmity and mo- -induced intoxication, effects of Ro15- sion, hepatocytes (rats), 493 lecular mass (bovine), 1060 4513 (rats), 880 Abhold, R. H. and Harding, J. W.: Metabo- imidazoline analogs, aorta (rats), 793 Mi, S. F., see Schulze, G. E., 178 lism of angiotensins II and III by inotropic positive effect, inositol tris- Alkondon, M., Rao, K. S. and Albuquerque, membrane-bound peptidases from phosphate increase in heart (rats), E. X.: Acetylcholinesterase reactiva- rat brain, 171 327 tom modify the functional properties Abiko, Y., see Hara, Y., 305 prazosin and indoramin, coronary of the nicotinic acetylcholine recep- Acetaminophen blood flow (dogs), 232 tor ion channel, 543 diminuition of hepatotoxicity, ethanol alpha-2 Allbee, W. E., see Kachur, J. F., 455 (rats), 129 effects of agonist, angiotensin convert- Allen, J. C., see Navran, S. S., 608 drug metabolite toxicity, human lympho- ing enzyme (guinea pigs), 932 Allescher, H.-C., see Daniel, E. E., 1002 cytes, cytochrome P-450 (rats), 956 idazoxan administration, blood pres- Aluminum, uptake, gut preparation (rats), inhibition ofconjugation, ranitidine, hep- sure (rats), 265 928 atotoxicity, 887 peripheral-acting antagonist (rats), 32 Amino acids Acetylcholinesterase presynaptic autoinhibition, central nor- excitatory muscarimc responses of AF-DX 116, su- adrenaline release (rats), 944 cAMP accumulation, role of chloride perior cervical ganglion (rabbits), 419 receptor subtypes, antagonist binding (guinea pigs), 299 reactivators, nicotinic acetylcholine re- (humans), 600 phencyclidine-like behavior, MK-801 ceptor ion channel (frogs), 543 alpha and beta, brown fat adenylate cy- (pigeons, rats, monkeys), 969 N-Acetylcysteine, pharmacologic interac- clase, norepinephrine (rats), 1075 Aminobenzotriazole, pulmonary clearance, tion, organic nitrates with thiols beta vasoactive drugs (rats), 402 (rats), 524 discriminative stimulus, clenbuterol -y-Aminobutyric acid Adair, S. E., see Navran, S. S., 608 (rats), 155 effects of Ro15-4513, intoxication, alco- Adams, L. M., see Rimele, T. J., 102 large coronary arteries (dogs), 936 hol-induced (rats), 880 Adejare, A., see Lamba-Kanwal, V. K., 793 stereospecificity, antagonists (rabbits), elimination of, osmotic shock (rats), 342 Adenosine triphosphatase, sodium-potas- 94 enhanced release by clonidine, alpha sium, norepinephrine release, kidney beta-i, homogeneous population, bovine adrenoceptors, cerebral cortex subre- (rats), 436 coronary artery (cows, guinea pigs, gions (rats), 682 Adenylate cyclase and rabbits), 67 receptor response, benzodiazepines, en- inhibition, muscarinic receptors, neos- AF-DX 1 16, muscarinic responses, superior teric nervous system (guinea pigs), triatum (rats), 658 cervical ganglion (rabbits), 419 250 responsiveness, norepinephrine, brown Affective disorders, effects of trihexypheni- Aminoglycosides, effects of antibiotics, neu- adipose tissue (rats), 1075 dyl and carbamazepine, substance P ronal calcium uptake (rats), 389 somatostatin receptor coupling, multiple and haloperidol, brain (rats), 982 Amione, J., see Szeto, H. H., 537 effector systems (mice), 225 Aging Amitriptyline stereoselectivity, ocular beta receptors effect of phenytoin and smoking, theoph- antihistaminic and antimuscarinic ef- (rabbits), 94 ylline oxidation and cortisol, healthy fects, ileal electrolyte transport, mus- stimulatory regulatory protein, neural men, 513 cle contractility (guinea pigs), 455 modulation, brown adipose tissue effects on neurotransmission, cardiac experimental poisoning, phenytoin pro- (rats), 1068 sympathetic neuroeffector junction phylaxis, cardiotoxicity (dogs), 216 Adgate, L., see Atchison, W. D., 394 (rats), 798 Amphetamine Adipose tissue inhibition of norepinephrine contrac- phenylethylamine and related drugs, do- brown tions, aorta and pulmonary artery, pamine release, mazindol binding adenylate cyclase, stimulatory regula- diltiazem (rats), 1016 (rabbits), 199 tory protein (rats), 1068 Ahmad, S., see Daniel, E. E., 1002 ventral mesencephalon injection, sensi- norepinephrine, adenylate cyclase re- AHR 11325, histamine H, antagonists, be- tivity, peripheral amphetamine and sponsiveness (rats), 1075 havioral effects, compared to halo- cocaine (rats), 1095 Adler, M. W., see Gochin, P. M., 569 peridol (monkeys), 471 Amphotericin B, adverse effect on renal Adrenal glands, norepinephrine content in Airway hemodynamics (rats), 594 tissues, time course (rats), 24 smooth muscle relaxation, peripheral type Analgesia Adrenoceptors benzodiazepine receptor (guinea effects of DPDYN (mice), 995 alpha pigs), 557 -endorphin-induced, intrathecal fl-fun- clonidine, ‘y-axninobutyric acid release smooth muscle volume and contractile re- altrexamine (mice), 587 (rats), 682 sponse (rabbits), 687 oxymetazoline-induced, tolerance, cross- cooling, central ear artery (rabbits), 89 Alaranta, S., see Klinge, E., 280 tolerance to intrathecal morphine inhibited norepinephrine contractions, Albrightson-Winslow, C. R., see Brooks, D. (rats), 319 diltiazem (rats), 1016 P., 211 pharmacology of SCH 34826 (mice), 829 receptor reserve, calcium channel Albuquerque, E. X., see Alkondon, M., 543 supraspinal and spinal opioid, Mu recep- blockers in vascular tissues (rats), Alcohol tor (mice), 13 673 chronic effects, pituitary and ovarian hor- Analgesics sodium pump stimulation, blood vessels mones, healthy women, 407 narcotic, efficacy and tolerance, mu (dogs), 608 effects on naloxone-stimulated luteiniz- opioid receptor (humans), 350 spinal vs. peripheral pharmacology, ing hormone, follicle-stimulating opiate agonists and antagonists, i4-hy- micturition (rats), 426 hormone, prolactin plasma levels droxydihydromorphinone hydra- alpha-i (monkey), 895 zones (mice), 8 1111 1112 Index Vol. 245

Andersen, M. E., see D’Souza, R. W., 563 sponse in airway tissue. Isometric acute and daily cocaine administration Andersson, R. G. G., see Lindgren, B. R., versus isotonic measurement, 687 (rats), 485 932 Artery effects of levorphanol, kappa-selective Anesthetics caudal, norepmephrine content in tissues, opioids (monkeys), 364 neuronal intracellular calcium concentra- time course (rats), 24 genetic factors in ethanol reinforcement tions, membrane fluidization (mice), central ear, cooling (rabbits), 89 (rats), 164 1 coronary performance in battery of complex oper- reduction of V,,,,,,, benzocaine, cardiac beta adrenoceptors (dogs), 936 ant tests, acute effects, tetrahydro- Purkinje fibers (dogs), 381 homogeneous population, beta-i adren- cannabinol (monkeys), 178 Angiotensin converting enzyme oceptors (cows, guinea pigs, and rab- phencyclidine-like, MK-801 (pigeons, apha-2 adrenoceptor agonist, clonidine, bits), 67 rats, monkeys), 969 inflammation (guinea pigs), 932 ischemic myocardial acidosis, MCI-176 Benavides, J., Peny, B., DuBois, A., Per- inhibition by perindopril (rats), 950 (dogs), 305 rault, G., Morel, E., Zivkovic, B. and Angiotensins II and III, metabolism by mesenteric Scatton, B.: In vivo interaction of membrane-bound peptidases, brain leukotriene D4 vasomotor relaxation, zolpidem with central benzodiaze- cGMP (dogs), 47 (rats), 171 pine (BZD) binding sites (as labeled norepinephrine content in tissues, time Antagonists, beta adrenergic, stereospecific- by [3H]RO 15-1788) in the mouse course (rats), 24 ity, ciliary process (rabbits), 94 brain. Preferential affmity of zolpi- vasodilation, minoxidril sulfate-in- Antibiotics dem for the w, (BZD,) subtype, 1033 duced (rabbits), 751 cephalosporin, mitochondrial respiratory Bennett, B. M., see Schroder, H., 413 pulmonary, inhibited norepinephrine toxicity (rabbits), 1054 Benzocaine, reduction of V, cardiac Pur- contractions, diltiazem (rats), 1016 effects on calcium uptake, isolated nerve kinje fibers (dogs), 381 route of delivery, liver extraction, vitamin terminals (rats), 389 Benzodiazepines D3 (rats), 975 Anticonvulsants, tetrazepam, psychophar- binding sites, interaction of zolpidem, Ashe, J. H., see Yarosh, C. A., 419 macological profile (rats, mice), 692, brain (mice), 1033 Aspirin 699 nonlinear pharmacokinetics (rats), 809 cerebral uptake, lipophilicity, plasma pro- Antidepressants tein binding (rats), 816 oral vs. i.v., inhibitor of cyclooxygenase discriminative stimulus properties, den- effect of experimental hypovolemia, des- activity, portacaval shunt (rats), 287 buterol (rats), 155 pyrogenic properties of tumor necrosis methyldiazepam (rats), 508 patterns of administration, antinocicep- factor (rabbits), 336 GABAA receptor response, enteric nerv- tive action, clomipramine (mice), 963 Assays, ligand affmity and molecular mass, ous system, small intestine (guinea Antidiuretic hormone, antagonist, SKF classification, alpha-i adrenoceptors pigs), 250 105494 (monkeys), 211 (bovine), 1060 peripheral type receptor, airway smooth Antiduretics, evaluation of vasopressin an- Asthma, cyclooxygenase products, arachi- muscle relaxation (guinea pigs), 557 tagonist, pharmacologic properties donic acid metabolism, bronchocon- precipitation of abstinence, nordiazepam, (rats), 1028 striction (dogs), 735 diazepam (dogs), 221 Antimycin A, magnesium distribution and Atchison, W. D., Adgate, L. and Beaman, tetrazepam, psychopharmacological pro- movements, aortic smooth muscle C. M.: Effects of antibiotics on up- file (rats, mice), 692, 699 (rabbits), 112 take of calcium into isolated nerve use of conditioned taste aversion, conflict Antinociception, opioid, naloxonazine, cen- terminals, 394 model, anxiolytic drugs (rats), 137 tral gastrointestinal propulsion Autonomic ganglia, nicotinic relaxation, be- Berger, J. G., see Chipkin, R. E., 829 (mice), 238 vine retractor penis muscle, 280 Bergman, J., see Howell, L. L., 364 Antioxidants, effect of extracellular calcium Autoradiography, elimination of ‘y-amino- Bergman, J. and Spealman, R. D.: Behav- omission, hepatocytes (rats), 493 butyric acid, benzodiazepine binding ioral effects of histamine H1 antago- Antipsychotics, discriminative stimulus (rats), 342 nists: Comparison with other drugs properties, clenbuterol (rats), 155 Autoreceptors, dopamine release, prefrontal and modification by haloperidol, 471 Anxiolytic drugs, use of conditioned taste cortex dopamine terminals (rabbits), Berkowitz, B. A., Arleth, A. J., Sung, C. P., aversion, conflict model (rats), 137 761 Kruse, L. I., DeWolf, W. E., Jr. and Aorta Ohlstein, E. H.: Effects of the novel activation of alpha-i adrenoceptors, imi- dopamine fi-hydroxylase inhibitor dazoline analogs (rats), 793 Baba, A., Nishiuchi, Y., Uemura, A. and SK&F 102698 on catecholamines and inhibition of norepinephrine contrac- Iwata, H.: Mechanism of excitatory blood pressure in spontaneously hy- amino acid-induced accumulation of tions, diltiazem (rats), 1016 pertensive rats, 850 cyclic AMP in hippocampal slices: interaction of neutrophils, vascular Bernton, E. W., see Bryant, H. U., 913 Role of extracellular chloride, 299 smooth muscle (rats), 102 Berta, P., see Phaneuf, S., 1042 Bache, R. J., Homans, D. C., Schwartz, J. new pulsatile preparation, vasodilator ef- Bhargava, H. N. and Gulati, A.: Kappa S. and Dai, X.-Z.: Differences in the fect, parathyroid hormone (rats), 723 opioid receptor activity in sponta- effects ofaipha-1 adrenergic blockade norepinephrine content in tissues, time neously hypertensive rat, 460 with prazosin and indoramin on cor- course (rats), 24 Bhaskaran, D. and Freed, C. R: Changes in onary blood flow during exercise, 232 smooth muscle cells, cAMP modulation, arterial blood pressure lead to baro- Bachy, A., see Keane, P. E., 699 phorbol ester (rats), 1042 receptor-mediated changes in norep- Bailey, J. R., see Schuize, G. E., 178 Apomorphine, pharmacological profile of Balis, F. M., see Collins, J. M., 466 inephrine and 5-hydroxyindoleacetic dopamine receptor agonists, brain di- Balkovetz, D. F., see Miyamoto, Y., 823 acid in rat nucleus tractus solitarius, alysis (rats), 257 Barbiturates 356 Arachidonic acid, metabolism in allergic GABAA receptor response, enteric nerv- Bicuculline, GABAA receptor response, en- bronchoconstriction, cyclooxygenase ous system, small intestine (guinea teric nervous system, small intestine products (dogs), 735 pigs), 250 (guinea pigs), 250 Araki, Y., see Kushiku, K., 311 use of conditioned taste aversion, conflict Bigelow, J. C., see Near, J. A., 921 ARC-239, alpha-2 receptor subtypes, antag- model, anxiolytic drugs (rats), 137 Biggar, W. D., see Uetrecht, J., 274 onist binding (humans), 600 Barnett, A., see Chipkin, R. E., 829 Billard, W., see Chipkin, R. E., 829 Arleth, A. J., see Berkowitz, B. A., 850 Bastide, P., see Eschalier, A., 963 Biziere, K., see Keane, P. E., 692, 699 Armour, C. L., Diment, L. M. and Black, J. Baum, H. P., see Mah, S. C., 1021 Bjornsson, T. D., Schneider, D. E. and L.: Relationship between smooth Beaman, C. M., see Atchison, W. D., 394 Hecht, A. R.: Effects of N-deacety- muscle volume and contractile re- Behavior lation and N-desulfation of heparin 1988 Index 1113

on its anticoagulant activity and in Bronchodilation, airway smooth muscle re- Calmodulin, enhancement of non-nicotinic vivo disposition, 804 laxation, peripheral type benzodiaze- responses, preganglionic stimulation, Black, J. L., see Armour, C. L., 687 pine receptor (guinea pigs), 557 cardiac sympathetic ganglia (dogs), Blood-brain barrier, transient osmotic mod- Brooks, D. P., Koster, P. F., Albrightson- 311 ification, delivery of interferon-a, Winslow, C. R., Stassen, F. L., Huff- Cannon, M., see Leeder, J. S., 956 brain (rats), 581 man, W. F. and Kinter, L. B.: SK&F Carbachol, smooth muscle volume, con- Blood flow, coronary, alpha-i adrenergic 105494 is a potent antidiuretic hor- tractile response, airway tissue (rab- blockade, prazosin and indoramin mone antagonist in the rhesus mon- bits), 687 (dogs), 232 key (macaca mulatto), 211 Carbamazepine, effects of chronic treat- Blood pressure Brown, A. M., see Scholtysik, G. 773 ment, substance P, brain (rats), 982 arterial, norepinephrine and 5-hydroxyin- Brown, M. J., see Harland, D., 265 Cardiotoxicity, phenytoin prophylaxis, ex- doleacetic acid, nucleus tractus soli- Brown adipose tissue, see Adipose tissue perimental amitriptyline poisoning tarius (rats), 356 Brush-border membrane, effects of pheno- (dogs), 216 catecholamines and, effects of SK&F thiazines, Na-H exchanger, proxi- Catecholamine 102698 (rats), 850 mal small intestine (rabbits), 823 beta adrenoceptors, large coronary arter- effects of intrathecal morphine and don- Bryant, H. U., Bernton, E. W. and Holaday, ies (dogs), 936 idine (rats), 444 J.: Morphine pellet-induced immu- blood pressure and, effects of SK&F idazoxan administration, plasma date- nomodulation in mice: Temporal re- 102698 (rats), 850 cholamine concentrations (rats), 265 lationships, 913 plasma concentrations, blood pressure, mechanisms of effects, intrathecal sero- Bryant, S. H., see Walsh, K. B. idazoxan administration (rats), 265 tonin (rats), 905 Bucchi, F., see Gambino, M. C., 287 Cathinone, tolerance to anorectic effects, thyrotropin-releasing hormone receptor Bulkley, T. J., see Crass, M. F., 723 sensitization, kappa opioid mecha- activation, sympathetic tone, vascu- Burak, E., see Gombar, C. T., 402 nisms (rats), 147 lature (rats), 41 Burks, T. F., see Heyman, J. S., 238 Cavadore, J. C., see Phaneuf, S., 1042 Blood vessels Burks, T. F., see Williams, C. L., 8 Central nervous system, site of action, hy- receptor reserve, calcium channel block- Butoxamine, stereoselectivity, beta recep- potensive effect, clonidine (cats), 373 ers, vascular tissues (rats), 673 tors (rabbits), 94 Cephalosporin, mitochondrial respiratory sodium pump stimulation, alpha adrener- Bylund, D. B., Ray-Prenger, C. and Murphy, toxicity, substrate uptake (rabbits), gic receptor subtypes (dogs), 608 T. J.: Alpha-2A and alpha-2B adre- 1054 Bodnar, R. J., see Williams, C. L., 8 nergic receptor subtypes: Antagonist Cerebral cortex binding Bognar, I. T. and Enero, M. A.: Influence of in tissues and cell lines con- apha-2 receptor subtypes, antagonist taming only one subtype, 600 a receptor reserve on the inhibition binding (humans), 600 by calcium channel blockers of alpha release of ‘y-aminobutyric acid, clonidine adrenoceptor-mediated responses in (rats), 682 Caffeine, chronic exposure, adverse preg- rat isolated vascular tissues, 673 Cerebrospinal fluid, selectivity of penetra- nancy outcome (monkeys), 1048 Bombesin, substance P receptors, gallblad- tion, pyrimidine dideoxyribonucleo- Calcium der muscle (dogs), 195 sides (monkeys), 466 alterations of contractile function, L-me- Botulism, clostridial neurotoxins, use of Cerletti, C., see Gambino, M. C., 287 thionine (rats), 664 pharmacological antagonists (mice), Cervenko, F. W., see Sherman, S. E., 319 epidermal growth factor-urogastrone ad- Chandrasekhar, R, Huang, H.-M. and Sun, 867 tions, smooth muscle from stomach Brain (guinea pigs), 625 G. Y.: Alterations in rat brain poly- cerebral uptake of benzodiazepines, lipo- extracellular omission, hepatocyte effect phosphoinositide metabolism after philicity, plasma protein binding (rats), 493, 501 acute ethanol administration, 120 (rats), 816 neuronal intracellular concentrations, an- Chapman, R., see Chipkin, R. E., 829 delivery of interferon-a, blood-brain bar- esthetics, membrane fluidization Chapnick, B. M., see Secrest, R. J., 47 rier modification (rats), 581 (mice), 1 Chelation dialysis, pharmacological profile, dopa- uptake into isolated nerve terminals, ef- effect of extracellular calcium omission, mine receptor agonists (rats), 257 fects, antibiotics (rats), 389 hepatocytes (rats), 493 effects of trihexyphenidyl and carbama- Calcium antagonists, airway smooth muscle estimation of mercury burdens, dimercap- zepine, substance P, haloperidol relaxation, peripheral type benzodi- topropane sulfonate (rats), 479 (rats), 982 azepine receptor (guinea pigs), 557 Chen, Z. M., see Gambino, M. C., 287 interaction of zolpidem, benzodiazepine Calcium channel Cherian, M. G., Miles, E. F., Clarkson, T. binding sites (mice), 1033 action of diltiazem, excitation-contrac- W. and Cox, C.: Estimation of mer- intravenous interferon-a admnistration, tion coupling, skeletal muscle fibers cury burdens in rats by chelation pharmacokinetics (rats), 574 (frogs), 531 with dimercaptopropane sulfonate, metabolism of angiotensins II and III, amphotericin B effect, renal hemody- 479 membrane-bound peptidases (rats), namics (rats), 594 Chiba, S., see Nakane, T., 936 171 blockers, receptor reserve, vascular tis- Chipkin, R. E., Berger, J. G., Billard, W., neuronal intracellular calcium concentra- sues (rats), 673 Iorio, L. C., Chapman, R. and Bar- tions, membrane fluidization (mice), effects of EGTA on sinoatrial node cells, nett, A.: Pharmacology of SCH 1 cardiotonic steroids (rabbits), 706 34826, an orally active enkephalinase polyphosphoinositide metabolism, alter- ischemic myocardial acidosis, attenuation inhibitor analgesic, 829 ations, acute ethanol administration by MCI-176, coronary artery occlu- Chloride (rats), 120 sion (dogs), 305 anticoagulant activity of heparin, N-de- Brainstem, hypotensive effect of clonidine, mechanism of norepinephrine release, so- acetylation, N-desulfation (rats), 804 central nervous system (cats), 373 dium-potassium adenosine triphos- excitatory amino acid-induced cAMP ac- Branch, R. A., see Jones, D. R., 816 phatase inhibition, kidney (rats), 436 cumulation, hippocampal slices Brase, D. A., see Lux, F., 187 somatostatin receptor coupling, multiple (guinea pigs), 299 Brault, A., see Gascon.Barr#{233}, M., 975 effector systems (mice), 225 Chlorpheniramine, histamine H1 antago. Bra., M. P., see Mello, N. K., 895 Calcium current, cardiac, blockade, ICS nists, behavioral effects, compared to Bremazocine, kappa opiold activity, spon. 205.930 (guinea pigs), 773 haloperidol (monkeys), 471 taneously hypertensive rats, 460 Callaham, M., Schumaker, H. and Pentel, Choi, P. W., see Goldberg, M. P., 1081 Bronchocoastriction, Atwaria antigenin- P.: Phenytoin prophylaxis of cardi. Choline acetyltransferase, inhibitors of (hu- duced, cyclooxygenase products, ars- otoxicity in experimental amitripty. man), 72 chidonic acid metabolism (dogs), 735 line poisoning, 216 Choline chloride, effects of’ EGTA on sinoa- 1114 Index Vol. 245

trial node cells, cardiotonic steroids T. J.: Use of a new pulsatile perfused metabolism, acute ethanol adminis- (rabbits),706 rat aorta preparation to study the tration (rats), 120 Chong, S., see Fung, H.-L., 524 characteristics of the vasodilator ef- Diazepam Chorev, M., see Laufer, R., 639 fect of parathyroid hormone, 723 desmethyldiazepam, effect, experimental Christ, D. D., see Kenna, J. G., 1103 Crawley, J. N., see Suzdak, P. D., 880 hypovolemia (rats), 508 Cigarette smoking, aging and drug interac- Cros, J., see Gairin, J. E., 995 precipitation of abstinence (dogs), 221 tions, theophylline and cortisol, Crowley, J. J., Cusack, B. J., Jue, S. G., tetrazepam, psychopharmacological pro- healthy men, 513 Koup, J. R., Park, B. K. and Vestal, file (rats, mice), 692, 699 Cipkus, L. A., see Meisheri, K. D., 751 R. E.: Aging and drug interactions. di Chiara, G., see Imperato, A., 257 Clare, S., see Szeto, H. H., 537 II. Effect of phenytoin and smoking Dihydroxyphenylglycol, release and metab- Clark, J. E., see Williams, C. L., 8 on the oxidation of theophylline and olism of norepinephrine, vas deferens Clark, M. T., see Lamba-Kanwal, V. K., 793 cortisol in healthy men, 513 (rats), 81 Clarkson, T. W., see Cherian, M. G., 479 Cubeddu, L. X., see Hoffman, I. S., 761 Diltiazem Clenbuterol, discriminative stimulus prop- Cubeddu, L. X., see Parker, E. M., 199 action on excitation-contraction coupling, erties, beta adrenergic involvement Cubela, R. B., see Jackson, B., 950 skeletal muscle fibers (frogs), 531 (rats), 155 Cusack, B. J., see Crowley, J. J., 513 inhibition of norepinephrine contrac- Clineschmidt, B. V., Pettibone, D. J., Lotti, Cyclic AMP tions, aorta and pulmonary artery V. J., Hucker, H. B., Sweeney, B. M., excitatory amino acid-induced accumula- (rats), 1016 Reiss, D. R, Lis, E. V., Huff, J. R. tion, hippocampal slices, role of chlo- mechanism of norepinephrine release, so- and Vacca, J.: A peripherally acting ride (guinea pigs), 299 dium-potassium adenosine triphos- alpha-2 adrenoceptor antagonist: L- phorbol ester modulation, aortic smooth phatase inhibition, kidney (rats), 436 659,066, 32 muscle cells (rats), 1042 Diment, L. M., see Armour, C. L., 687 Clomipramine, patterns of administration, Cyclic GMP Dimercaptopropane sulfonate, estimation of antidepressants (mice), 963 endothelial regulation, vascular re- mercury burdens by chelation (rats), Clonidine sponses, hypertension (rats), 53 479 hypotensive effect, site of action, central relationship to vasomotor relaxation, leu- Diphenhydramine, histamine H1 antago- nervous system (cats), 373 kotriene D4-induced (dogs), 47 nists, behavioral effects, compared to intrathecal morphine and, blood pressure Cycloheximide, growth inhibition by pros- haloperidol (monkeys), 471 effects (rats), 444 taglandins, site and mechanism (hu- Discriminative stimulus release of ‘y-aminobutyric acid, alpha mans), 294 isomers of pentobarbital and secobarbital adrenoceptors, cerebral cortex subre- Cyclooxygenase, platelet vs. vascular activ- (pigeons), 389 ity, oral aspirin, portacaval shunt gions (rats), 682 properties of clenbuterol, beta adrenergic Clostridial, neurotoxins, use of pharmaco- (rats), 287 involvement (rats), 155 logical antagonists (mice), 867 Cytochrome P-450 tolerance and cross-tolerance, fentanyl drug metabolite toxicity, human lympho- Coagulation, anticoagulant activity of hep- and morphine (rats), 17 arm, N-deacetylation, N-desulfation cytes (rats), 956 Diuretics, renal action of 5-8666 (rats), 644, inhibited metabolism of retinoic acid, ke- (rats), 804 651 toconazole (hamsters), 718 Cocaine Donohue, S. J., Stitzel, R. E. and Head, R. acute and daily administration, behav- pulmonary clearance, vasoactive drugs J.: Time course of changes in the (rats), 402 ioral and neurochemical effects norepinephrine content of tissues (rats), 485 from spontaneously hypertensive and Wistar Kyoto rats, 24 amphetamine injection, ventral mesen- Dai, X.-Z., see Bache, R. J., 232 cephalon, sensitivity (rats), 1095 Daly, R. N., Goldberg, P. B. and Roberts, Dopamine Coene, M.-C., see Van Wauwe, J. P., 718 J.: Effects of age on neurotransmis- acute and daily cocaine administration, Collins, J. M., Klecker, R. W., Jr., Kelly, J. sion at the cardiac sympathetic neu- behavioral and neurochemical effects A., Roth, J. S., McCully, C. L., Balis, roeffector junction, 798 (rats), 485 F. M. and Poplack, D. G.: Pyrimidine Daniel, E. E., Kostolanska, F., Allescher, amphetamine injection, ventral mesen- dideoxyribonucleosides: Selectivity H.-D., Ahmad, S. and Fox, J. E. T.: cephalon, sensitization (rats), 1095 of penetration into cerebrospinal Local actions of trimebutine maleate comparison of uptake, striatal chopped fluid, 466 in canine small intestine, 1002 tissue, synaptosomes (rats), 921 Conder, G. A., see Richards, I. M., 735 Daniel, L. C. and Harris, R. A.: Neuronal 1-methyl-4-phenylpyridinium-induced ef- S#{176}-Conotoxin, mechanism of norepinephrine intracellular calcium concentrations fluxes, striatum (rats), 858 release, sodium-potassium adenosine are altered by anesthetics: Relation- muscarmnic receptor-mediated inhibition, triphosphatase inhibition, kidney ship to membrane fluidization, 1 adenylate cyclase, neostriatum (rats), (rats), 436 Danilo, P., Jr., see Spinelli, W., 381 658 Contractility Dapsone, metabolism to a hydroxylamine, receptor agonists, pharmacological pro- cardiac, phospholipid N-methylation, L- human neutrophils, mononuclear file, brain dialysis (rats), 257 methionine (rats), 664 cells, 274 release, prefrontal cortex dopamine ter- relationship to smooth muscle volume, Da Silva, A. M. T., see Gatti, P. J., 373 minals, autoreceptors (rabbits), 761 airway tissue (rabbits), 687 de Gaetano, G., see Gambino, M. C., 287 release and mazindol binding, ampheta- Convulsion, precipitation of abstinence, Dent, J. G., see Rogers, S. A., 887 mine, phenylethylamine (rabbits), nordiazepam, diazepam (dogs), 221 De Schryver-Kecskemeti, K., see Spaethe, 199 Cools, W., see Van Wauwe, J. P., 718 S. M., 1088 Dopamine fi-hydroxylase, SK&F 102698, Cooper, B. R., see Ervin, G. N., 137 Desmethyldiazepam, effect of experimental catecholamines, blood pressure Corpus striatum, dopamine uptake, synap- hypovolemia (rats), 508 (rats), 850 tosomes (rats), 921 De Vries, J., see Rollema, H., 858 Drobny, H., see Valenta, B., 944 Corticosterone, elevation of prolactin, 3,4- Dewey, W. L., see Lux, F., 187 D’Souza, R. W., Francis,.W. R. and Ander- methylenedioxymethamphetamine DeWolf, W. E., Jr., see Berkowitz, B. A., sen, M. E.: Physiological model for (rats), 873 850 tissue glutathione depletion and in- Cortisol, effect of phenytoin and smoking, Dexamethasone, pyrogenic properties of tu- creased resynthesis after ethylene aging and drug interactions, healthy mor necrosis factor (rabbits), 336 dichloride exposure, 563 men, 513 Dhalla, N. S., see Gupta, M. P., 664 Dubey, R. K., see Knodell, R. G., 845 Coulombe, P. R., see Purdy, R. E., 67 Diabetes, effects of morphine administra- DuBois, A., see Benavides, J., 1033 Cox, C., see Cherian, M. G., 479 tion, blood glucose (mice), 187 DUffy, P., see Kalivas, P. W., 485 Crass, M. F., III, Hulsey, S. M. and Bulkley, Diacylglycerols, brain polyphosphoinositide DuMars, L. A., see Kalivas, P. W., 485 1988 Index 1115

Durant, P. A. C., Lucas, P. C. and Yaksh, Ethanol Cros, J.: [D-Pro’#{176}]-Dynorphin(l-ll) T. L.: Micturition in the unanes- acute, polyphosphoinositide metabolism, is a kappa-selective opioid analgesic thetized rat: Spinal vs. peripheral brain (rats), 120 in mice, 995 pharmacology of the adrenergic sys- diminuition, hepatotoxicity, acetamino- Gallbladder, bombesin and substance P re- tem, 426 phen (rats), 129 ceptors (dogs), 195 Dwyer, G., see Szeto, H. H., 537 reinforcement, genetic factors (rats), 164 Gambino, M. C., Passaghe, S., Chen, Z. M., Dynorphin A, DPDYN, analgesic effects Ethylene dichloride, physiological model, Bucchi, F., Gori, G., Latini, R., de (mice), 995 tissue glutathione depletion, resyn- Gaetano, G. and Cerletti, C.: Selec- thesis (rats, mice), 563 tivity of oral aspirin as an inhibitor Ethylene glycol-bis-(fl-aminoethyl ether)- of platelet vs. vascular cycbooxygen- Ear, central artery, cooling of (rabbits), 89 N,N’-tetraacetic acid, see EGTA ase activity is reduced by portacaval Effeney, D. J., see Pond, S. M., 291 Ethylketocyclazocine, kappa opioid activity, shunt in rats, 287 EGTA, effects on sinoatrial node cells, car- spontaneously hypertensive rats, 460 Ganapathy, V., see Miyamoto, Y., 823 diotonic steroids (rabbits), 706 Exercise, coronary blood flow, alpha-i ad- Ganglia Eicosanoid, suppressed production, essen- renergic blockade, prazosin and in- nodose, superior cervical ganglion rein- tial fatty acid deficiency, hydrone- doramin (dogs), 232 nervation, afferent vagus (cats), 990 phrosis (rabbits), 1088 sympathetic neuroeffector responses, vas- Eisenhofer, G., Ropchak, T. G., Kopin, I. J. Faden, A. I., Sacksen, I. and Noble, L. J.: opressin, hindlimb vasculature (rab- and Goldstein, D. S.: Release, metab- bits), 779 olism and intraneuronal disposition Opiate-receptor antagonist nalme- Gascon-Barr#{233}, M., Huet, P.-M., St-Onge- of exogenous, endogenous and newly fene improves neurological recovery Brault, G., Brault, A. and Kassissia, synthesized norepinephrine in the rat after traumatic spinal cord injury in rats through a central mechanism, I.: Liver extraction of vitamin D3 is vas deferens, 81 independent of its hepatic venous or Electrolytes, ileal transport and muscle con- 742 Fatty acids, deficiency, hydronephrosis, ei- arterial route of delivery. Studies in tractility, amitriptyline effects isolated-perfused rat liver prepara- (guinea pigs), 455 cosanoid production (rabbits), 1088 Fenoterol, homogeneous population of beta- tions, 975 Electron microscopy, new pulsatile perfused 1 adrenoceptors, coronary artery Gastrointestinal tract aorta preparation, vasodilator effect, (cows, aluminum uptake (rats), 928 parathyroid hormone (rats), 723 guinea pigs, and rabbits), 67 Fentanyl, tolerance and cross-tolerance, dis- local actions in small intestine, trimebu- Elfring, G., see Richards, I. M., 735 tine maleate (dogs), 1002 Emmett-Oglesby, M. W., Shippenberg, T. S. criminative stimulus (rats), 17 Ferro, C. P., see Hoffman, I. S., 761 propulsion, dissociation of opioid antino- and Hen, A.: Tolerance and cross- ciception, naloxonazine (mice), 238 tolerance to the discriminative stim- Fetus, breathing movements, dual action of Gatti, P. J., Hill, K. J., Da Silva, A. M. T., ulus properties of fentanyl and mor- morphine (lambs), 537 Fever, properties of tumor necrosis factor Norman, W. P. and Gillis, R. A.: Cen- phine, 17 (rabbits),336 tral nervous system site of action for fi-Endorphin, -induced analgesia, intrathe- cal fi-funaltrexamine (mice), 587 Fialip, J., see Eschalier, A., 963 the hypotensive effect of clonidine in Fibroblasts, lung, desensitization, guanylate the cat, 373 Endothelial cells, regulation of cyclic GMP, cyclase Gebhart, G. F., see Solomon, R. E., 444 vascular responses, hypertension (rats), 413 Fielding, R. M., see Pond, S. M., 291 Genetics, factors in ethanol reinforcement (rats), 53 Endothelium, new pulsatile aorta prepara- Fitzpatrick, F. A. and Lawson, C. F.: My- (rats), 164 otropic activity of leukotriene B4 on Gentisamide, competing pathways in drug tion, vasodilator effect, parathyroid lung parenchyma strips is not neces- hormone (rats), 723 metabolism (rats), 614 Endothelium-dependent relaxation, leuko- sexily attributable to thromboxane A2 George, F. R., see Suzuki, T., 164 triene D4-induced, cGMP relation- release, 839 Gilbert, S. G., Rice, D. C., Reuhl, K. R. and ship (dogs), 47 Flunarizine, mechanism of norepinephrine Stavric, B.: Adverse pregnancy out- Endothelium-derived relaxing factor, cyclic release, sodium-potassium adenosine come in the mozikey (Macaca fasci- GMP and vascular responses, hyper- triphosphatase inhibition, kidney cularis) after chronic caffeine expo- (rats), 436 tension (rats), 53 sure, 1048 Enero, M. A., see Bognar, I. T., 673 Follicle-stimulating hormone, alcohol ef- Gillis, R. A., see Gatti, P. J., 373 fects, luteinizing hormone (monkey), Enkephalinase, pharmacology of SCH Gilon, C., see Laufer, R., 639 895 34826 (mice), 829 Glaucoma, stereoselectivity, beta receptors Epidermal growth factor, -urogastrone, Fox, J. E. T., see Daniel, E. E., 1002 (rabbits), 94 smooth muscle from stomach, indo- Francis, W. R., see D’Souza, R. W., 563 Glucose, blood, effects, morphine adminis- Frau, R., see Imperato, A., 257 methacin (guinea pigs), 625 tration (mice), 187 Fredericks, W. R., see Greig, N. H., 581 Epinephrine Glucuronidation Freed, C. R., see Bhaskaran, D., 356 activation of alpha-i adrenoceptors, imi- conjugation of gentisamide, competing Freed, M. S., see Spaethe, S. M., 1088 dazoline analogs (rats), 793 pathways (rats), 614 Frenken, M., see Kaumann, A. J., 1010 plasma catecholamine concentrations, nonlinear first-pass metabolism, salicyl- Fujiwara, M., see Ohno, K., 294 blood pressure, idazoxan administra- amide, portacaval transposition Fujiwara, M., see Okamoto, T., 990 tion (rats), 265 (dogs), 291 Epithelium, airway smooth muscle relaxa- Fukushima, M., see Ohno, K., 294 Glutamate, excitatory amino acid-induced tion, peripheral type benzodiazepine fi-Funaltrexamine, intracerebroventricular cAMP accumulation, hippocampal receptor (guinea pigs), 557 fl-endorphin-induced analgesia slices, role of chloride (guinea pigs), (mice), 587 Ervin, G. N. and Cooper, B. R: Use of 299 conditioned taste aversion as a con- Fung, H.-L., Chong, S., Kowaluk, E., Hough, Glutathione flict model: Effects of anxiolytic K. and Kakemi, M.: Mechanisms for drug metabolite toxicity, human lympho- the pharmacologic interaction of or- drugs, 137 cytes, cytochrome P.450 (rats), 956 Eschalier, A., Fialip, J., Varoquaux, 0., ganic nitrates with thiols. Existence tissue depletion and increased resyn- of an extracellular pathway for the Makambila, M.-C., Marty, H. and thesis, physiological model, ethylene Bastide, P.: Patterns of administra- reversal of nitrate vascular tolerance dichloride exposure (rats, mice), 563 by N-acetylcysteine, 524 tion of antidepressants in animals. I. Glyceryl trinitrate, -induced desensitize- Furukawa, T., see Kushiku, K., 311 Implications for antinociceptive ac- tion, guanylate cyclase, lung fibro- tion of clomipramine in mice, 963 blasts (rats), 413 Estradiol, chronic alcohol effects, healthy Gaginella, T. S., see Kachur, J. F., 455 Gochin, P. M., Kirby, A. and Adler, M. W.: women, 407 Gairin, J. E., Gout, R., Meunier, J.-C. and Dose dependent morphine-induced 1116 Index Vol. 245

pupillary fluctuations in the rat: Fre- Hamada, A., see Lamba-Kanwal, V. K., 793 ranitidine, inhibition, acetaminophen quency analysis, 569 Hanada, S., see Taniyama, K., 250 conjugation, 887 Goldberg, M. P., Viseskul, V. and Choi, D. Hanano, M., see Miyamoto, Y., 823 Herz, A., see Emmett-Oglesby, M. W., 17 W.: Phencyclidine receptor ligands Hara, Y., Ichihara, K. and Abiko, Y.: MCI- Hexobarbital, oxidative metabolism, liver attenuate cortical neuronal injury 176, a novel calcium channel blocker, (humans), 845 after N-methyl-D-aspartate exposure attenuates the ischemic myocardial Heyman, J. S., Williams, C. L., Burks, T. or hypoxia, 1081 acidosis induced by coronary artery F., Mosberg, H. I. and Porreca, F.: Goldberg, P. B., see Daly, R. N., 798 occlusion in dogs, 305 Dissociation of opioid antinocidep- Goldstein, D. S., see Eisenhofer, G., 81 Harding, J. W., see Abhold, R. H., 171 tion and central gastrointestinal pro- Gombar, C. T., Burak, E., Harper, N. and Harker, C. T. and Vanhoutte, P. M.: Cooling pulsion in the mouse: Studies with Smith, B. R.: Pulmonary clearance of the central ear artery of the rabbit: naloxonazine, 238 vasoactive drugs: N-oxidation of Myogenic and adrenergic responses, HI-6, acetylcholinesterase reactivators, ni- SK&F 86466 in the isolated perfused 89 cotinic acetylcholine receptor ion rat lung, 402 Harland, D. and Brown, M. J.: Effects of channel (frogs), 543 Goossens, J., see Van Wauwe, J. P., 718 acute and chronic administration of Hill, K. J., see Gatti, P. J., 373 Gori, G., see Gambino, M. C., 287 idazoxan on blood pressure and Hippocampus, excitatory amino acid-in- Goto, K., see Miyamae, S.-I., 706 plasma catecholamine concentra- duced cAMP accumulation, role of Gout, R., see Gairin, J. E., 995 tions of rats, 265 chloride (guinea pigs), 299 Granneman, J. G. and MacKenzie, R. G.: Harper, N., see Gombar, C. T., 402 Histamine Neural modulation ofthe stimulatory Harris, D. N., see Hedberg, A., 786 amitriptyline effects, ileum electrolyte regulatory protein of adenylate cy- Harris, R. A., see Daniel, L. C., 1 transport, muscle contractility clase in rat brown adipose tissue, Hashimoto, K., see Nakane, T., 936 (guinea pigs), 455 1068 Hashimoto, S., see Taniyama, K., 250 H1 antagonists, behavioral effects, com- Granneman, J. G.: Norepinephrine infu- Head, R. J., see Donohue, S. J., 24 pared to haloperidol (monkeys), 471 sions increase adenylate cyclase re- Heart mucosal protective action, hydrochloric sponsiveness in brown adipose tissue, alterations of contractile function, L-me- acid-induced lesions (rats), 632 1075 thionine (rats), 664 smooth muscle volume, contractile re- Grider, J. R., see Severi, C., 195 inotropic positive effect, inositol trisphos- sponse, airway tissue (rabbits), 687 Grieg, N. H., Fredericks, W. R., Holloway, phate increase (rats), 327 use of conditioned taste aversion, conflict H. W., Soncrant, T. T. and Rapoport, ischemic myocardial acidosis, attenuation model, anxiolytic drugs (rats), 137 S. I.: Delivery of human interferon- by MCI-176, coronary artery occlu- Hofbauer, K. G., see Mah, S. C., 1021, 1028 alpha to brain by transient osmotic sion (dogs), 305 Hoffman, I. S., Talmaciu, R. K., Ferro, C. blood-brain barrier modification in membrane current blockade, ICS 205-930 P. and Cubeddu, L. X.: Sustained the rat, 581 (guinea pigs), 773 high release at rapid stimulation Grieg, N. H., Soncrant, T. T., Wozniak, K. norepinephrine content in tissues, time rates and reduced functional autore- M. and Rapoport, S. I.: Plasma and course (rats), 24 ceptors characterize prefrontal cor- tissue pharmacokinetics of human prostaglandin synthesis by cholinergic tex dopamine terminals, 761 interferon-alpha in the rat after its stimuli, muscarmnic M2 receptors Hogenboom, F., see Schoffelmeer, A. N. M., intravenous administration, 574 (rabbits), 59 658 Griffin, R. L., see Richards, I. M., 735 Purkinje fibers, reduction of Vm,, benzo- Holaday, J., see Bryant, H. U., 913 Grimes, D., see Rimele, T. J., 102 caine (dogs), 381 Hollenberg, M. D., see Muramatsu, I., 625 Growth factor, epidermal growth factor-uro- sympathetic ganglia, calmodulin, non-ni- Holloway, H. W., see Greig, N. H., 581 gastrone actions, smooth muscle cotinic responses (dogs), 311 Homans, D. C., see Bache, R. J., 232 from stomach (guinea pigs), 625 sympathetic neuroeffector junction, ef- Hormones, pituitary and ovarian, chronic Grundstr#{246}m, N., see Lindgren, B. R., 932 fects of age, neurotransmission alcohol effects, healthy women, 407 GTP-binding proteins, somatostatin recep- (rats), 798 Hough, K., see Fung, H.-L., 524 tor coupling, multiple effector sys- Heaslip, R. J., see Rimele, T. J., 102 Howell, L. L., Bergman, J. and Morse, W. tems (mice), 225 Hecht, A. R., see Bjornsson, T. D., 804 H.: Effects oflevorphanol and several Guanylate cyclase, glyceryl trinitrate-in- Hedberg, A., Hall, S. E., Ogletree, M. L., kappa-selective opioids on respira- duced desensitization, lung fibro- Harris, D. N. and Liu, E. C.-K.: Char- tion and behavior in rhesus monkeys, blasts (rats), 413 acterization of [5,6-3H]SQ 29,548 as 364 Gudelsky, G. A., see Nash, J. F., Jr., 873 a high affinity radioligand, binding to Hsu, C.-Y., see Tune, B. M., 1054 Guengerich, F. P., see Knodell, R. G., 845 thromboxane A2/prostaglandin H2- HT29 cells, alpha-2 receptor subtypes, an- Guild, S., see Reisine, T., 225 receptors in human platelets, 786 tagonist binding (humans), 600 Gulati, A., see Bhargava, H. N., 460 HeLa cells, growth inhibition by prostaglan- Huang, H.-M., see Chandrasekhar, R., 120 Gupta, M. P., Panagia, V. and Dhalla, N. dms, site and mechanism (humans), Hucker, H. B., see Clineschmidt, B. V., 32 S.: Phospholipid N-methylation-de- 294 pendent alterations of cardiac con- Huet, P.-M., see Gascon-Barr#{233}, M., 975 Helke, C. J. and Phillips, E. T.: Thyrotro- Huff, J. R., see Clineschmidt, B. V., 32 tractile function by L-methionine, pin-releasing hormone receptor acti- Huffman, W. F., see Brooks, D. P., 211 664 vation in the spinal cord increases Hulsey, S. M., see Crass, M. F., 723 Gut, preparation, aluminum uptake (rats), blood pressure and sympathetic tone 928 Hydrochloric acid, -induced lesions, mu- to the vasculature and the adrenals, cosal protective action, histamine 41 (rats), 632 Hahn, E. F., see Williams, C. L., 8 Hemodynamics, renal, amphotericin B ef- Hydronephrosis, essential fatty acid defi- Haiech, J., see Phaneuf, S., 1042 fect (rats), 594 diency, suppression, eicosanoid pro- Hall, S. D., see Jones, D. R., 816 Henry, D. E., see Rimele, T. J., 102 duction (rabbits), 1088 Hall, S. E., see Hedberg, A., 786 Heparin, anticoagulant activity, N-deace- 14-Hydroxydihydromorphinone hydra- Haloperidol tylation, N-desulfation (rats), 804 zones, analgesic actions, opiate ago- behavioral effects, histamine H1 antago- Hepatocytes, effect of extracellular calcium nists and antagonists (mice), 8 nists (monkeys), 471 omission (rats), 493, 501 5-Hydroxyindoleacetic acid, norepinephrine effects ofchronic treatment, trihexyphen- Hepatotoxicity and, arterial blood pressure changes, idyl and carbamazepine, brain (rats), ethanol-acetaminophen interaction nucleus tractus solitarius (rats), 356 982 (rats), 129 hydroxylamine, dapsone metabolism, hu- Halothane, hepatotoxicity, metabolic basis, halothane, metabolic basis, drug hyper- man neutrophils, mononuclear cells, drug hypersensitivity (humans), 1103 sensitivity (humans), 1103 274 1988 Index 1117

1-5-Hydroxytryptophan, use of conditioned Inoue, N., see Kushiku, K., 311 encephalon sensitizes rats to periph- taste aversion, conflict model, anx- Interferon-a eral amphetamine and cocaine, 1095 iolytic drugs (rats), 137 delivery to brain, blood-brain barrier Kassissia, I., see Gascon-Barr#{233}, M., 975 Hyperprolactinemia, chronic alcohol ef- modification (rats), 581 Kaumann, A. J. and Frenken, M.: IC! 169, fects, healthy women, 407 intravenous administration, plasma and 369 is both a competitive antagonist Hypersensitivity, drug, metabolic basis, hal- tissue pharmacokinetics (rats), 574 and an allosteric activator of the ar- othane hepatotoxicity (humans), Intestine, nonlinear first-pass metabolism, terial 5-hydroxytryptamine2 receptor 1103 salicylamide, portacaval transposi- system, 1010 Hypertension tion (dogs), 291 Keane, P. E., Bachy, A., Morre, M. and effects of SK&F 102698, catecholamines, Intestine, small Biziere, K.: Tetrazepam: a benzodi- blood pressure (rats), 850 effects of phenothiazines, Na-H ex- azepine which dissociates sedation endothelial regulation, cyclic GMP, vas- changer, brush-border membrane from other benzodiazepine activities. cular responses (rats), 53 (rabbits), 823 II. In vitro and in vivo interactions spontaneously hypertensive rats, kappa GABAA receptor response, benzodiaze- with benzodiazepine binding sites, opioid activity, 460 pines, barbiturates (guinea pigs), 250 699 Hypotension local actions of trimebutine maleate Keane, P. E., Simiand, J., Morre, M. and alpha-2 adrenoceptor agonist, inflamma- (dogs), 1002 Biziere, K.: Tetrazepam: A benzodi- tory skin responses (guinea pigs), 932 Intoxication, alcohol-induced, effects of azepine which dissociates sedation effect of clonidine, central nervous system Ro15-4513 (rats), 880 from other benzodiazepine activities. (cats), 373 Iorio, L. C., see Chipkin, R. E., 829 I. Psychopharmacological profile in thiol-organic nitrate interaction (rats), Ischemia, myocardial acidosis, attenuation rodents, 692 524 by MCI-176, coronary artery occlu- Kelly, J. A., see Collins, J. M., 466 Hypovolemia, desmethyldiazepam effects sion (dogs), 305 Kenna, J. G., Satoh, H., Christ, D. D. and (rats), 508 Isoproterenol PohI, L. R.: Metabolic basis for a drug Hypoxia, phencyclidine receptor ligands, homogeneous population of beta-i adren- hypersensitivity: Antibodies in sera cortical neuronal injury (mice), 1081 oceptors, coronary artery (cows, from patients with halothane hepa- guinea pigs, and rabbits), 67 titis recognize liver neoantigens that micturition, spinal vs. peripheral phar- contain the trifluoroacetyl group de- Ichihara, K., see Hara, Y., 305 macology, adrenergic system (rats), IC! 118,551, homogeneous population of rived from halothane, 1103 426 Ketoconazole, inhibition of all-trans-reti- beta-i adrenoceptors, coronary artery use of conditioned taste aversion, conflict (cows, guinea pigs, and rabbits), 67 noic acid (hamsters), 718 model, anxiolytic drugs (rats), 137 Kidney IC! 169,369, arterial 5-hydroxytryptamine2 Itoh, H., see Muramatsu, I., 625 action of novel uricosuric diuretic, 5-8666 receptor system (calves), 1010 Iwasa, T., see Kushiku, K., 311 ICS 205-930, cardiac membrane currents (rats), 644, 651 Iwata, H., see Baba, A., 299 hemodynamics, amphotericin B effect (guinea pigs), 773 Iwatsubo, T., see Miyamoto, Y., 823 Idazoxan (rats), 594 acute and chronic administration, blood intravenous interferon-a administration, pharmacokinetics (rats), 574 pressure, plasma catecholamine con- Jackson, B., Cubela, R. B. and Johnston, C. mechanism of norepinephrine release, so- centrations (rats), 265 I.: Inhibition of tissue angiotensin dium-potassium adenosine triphos- hypotensive effect of clonidine, central converting enzyme by perindopril: In phatase inhibition (rats), 436 nervous system (cats), 373 vivo assessment in the rat using ra- norepinephrine content in tissues, time Ileum, electrolyte transport and muscle con- dioinhibitor binding displacement, course (rats), 24 tractility, amitriptyline effects 950 Kinter, L. B., see Brooks, D. P., 211 (guinea pigs), 455 Jackson, E. K., see Jones, D. R., 816 Kirby, A., see Gochin, P. M., 569 Imai, M., see Shimizu, T., 644, 651 Jaiswal, N., see Sastry, B. V. R., 72 Kiecker, R. W., Jr., see Collins, J. M., 466 Imidazoline analogs, alpha-i adrenoceptors, Jaiswal, N. and Malik, K. U.: Prostaglandin Klinge, E., Alaranta, S. and Sj#{246}strand, N. activation, aorta (rats), 793 synthesis elicited by cholinergic stim- 0.: Pharmacological analysis of ni- Immunomodulation, morphine pellet-in- uli is mediated by activation of M2 cotinic relaxation of bovine retractor duced (mice), 913 muscarinic receptors in rabbit heart, Imoto, Y., see Scholtysik, G., 773 59 penis muscle, 280 Klockowski, Levy, G.: Kinetics of Imperato, A., Tanda, G., Frau, R. and di Janson, V. E., see Sastry, B. V. R., 72 P. M. and drug action in disease states. XXV. Chiara, G.: Pharmacological profile Jemelka, S. K., see Navran, S. S., 608 of dopamine receptor agonists as Johanson, C. E., see Nencini, P., 147 Effect of experimental hypovolemia studied by brain dialysis in behaving Johnston, C. I., see Jackson, B., 950 on the pharmacodynamics and phar- rats, 257 Jones, D. R., Hall, S. D., Jackson, E. K., macokinetics of desmethyldiazepam, Indomethacin Branch, R. A. and Wilkinson, G. R.: 508 epidermal growth factor-urogastrone ac- Cerebral uptake of benzodiazepines: Knodell, R. G., Dubey, R. K., Wilkinson, G. tions (guinea pigs), 625 Effects of lipophilicity and plasma R. and Guengerich, F. P.: Oxidative pyrogenic properties of tumor necrosis protein binding, 816 metabolism ofhexobarbital in human factor (rabbits), 336 Jue, S. G., see Crowley, J. J., 513 liver: Relationship to polymorphic 5- Indoramin, alpha-i adrenergic blockade, mephenytoin 4-hydroxylation, 845 coronary blood flow, during exercise Kook, W., Woods, J. H. and Winger, G. D.: (dogs), 232 Kachur, J. F., Allbee, W. E. and Gaginella, MK-801, a proposed noncompetitive Inflammation, alpha-2 adrenoceptor ago- T. S.: Antihistaminic and antimus- antagonist of excitatory amino acid nist, angiotensin converting enzyme carmnic effects of amitriptyline on neurotransmission, produces phen- (guinea pigs), 932 guinea pig ileal electrolyte transport cyclidine-like behavioral effects in pi- Inositol trisphosphate, inotropic positive ef- and muscle contractility in vitro, 455 geons, rats and rhesus monkeys, 969 fect, alpha-i adrenoceptors, heart Kadokawa, T., see Nakumura, H., 336 Kolm, P., see Shirasaki, Y., 53 (rats), 327 Kakemi, M., see Fung, H.-L., 524 Kopin, I. J., see Eisenhofer, G., 81 Inotropic effect Kalivas, P. W., Duffy, P., DuMars, L. A. Koster, P. F., see Brooks, D. P., 211 negative, platelet-activating factor and Skinner, C.: Behavioral and neu- Kostolanska, F., see Daniel, E. E., 1002 (guinea pigs), 124 rochemical effects of acute and daily Koup, J. R., see Crowley, J. J., 513 positive, alpha-i adrenoceptor, inositol cocaine administration in rats, 485 Kowaluk, E., see Fung, H.-L., 524 trisphosphate increase in heart Kalivas, P. W. and Weber, B.: Ampheta- Kranenborg, G., see Rollema, H., 858 (rats), 327 mine injection into the ventral mes- Kruse, L. E., see Berkowitz, B. A., 850 1118 Index Vol. 245

Kuhr, W. G., see Rollema, H., 858 inotropic positive effect, inositol trisphos- Mahacha, V., see Pond, S. M., 291 Kurahashi, K., see Okamoto, T., 990 phate increase, heart (rats), 327 Makambila, M.-C., see Eschalier, A., 963 Kushiku, K., Araki, Y., Furukawa, T., Iwasa, use of conditioned taste aversion, conflict Makhlouf, G. M., see Severi, C., 195 T., Inoue, N. and Miyamoto, E.: In- model, anxiolytic drugs (rats), 137 Malik, K. U., see Jaiswal, N., 59 crement of calmodulin in proportion Liu, E. C.-K., see Hedberg, A., 786 Malik, K. U., see Mohy El-Din, M. M., 436 to enhancement of non-nicotinic re- Liver Martin, W. R., see McNicholas, L. F., 221 sponses after preganglionic stimula- conjugation of gentisamide, competing Marty, H., see Eschalier, A., 963 tion of the dog cardiac sympathetic pathways (rats), 614 Mataga, N., see Mitsushio, H., 982 ganglia, 311 extraction ofvitamin D3, route of delivery Mathiasen, J. R., see Vaught, J. L., 13 (rats), 975 Mazindol, binding, dopamine release, am- halothane hepatotoxicity, metabolic ba- phetamine (rabbits), 199 L-659,066, peripherally-acting alpha-2 ad- sis, drug hypersensitivity (humans), McCabe, H. T., Olsen, R W., Yezuita, J. P. renoceptor antagonist (rats), 32 1103 and Wamsley, J. K.: Osmotic shock: Lactate, 1-methyl-4-phenylpyridinium-in- intravenous interferon-a administration, A method to eliminate endogenous y- duced effluxes, striatum (rats), 858 pharmacokinetics (rats), 574 aminobutyric acid and account for Lamba-Kanwal, V. K., Hamada, A., Ade- oxidative metabolism ofhexobarbital (hu- the influence on benzodiazepine jars, A., Clark, M. T., Miller, D. D. mans), 845 binding affinity in autoradiographic and Patil, P. N.: Activation of alpha- tissue glutathione depletion and resyn- studies, 342 1 adrenoreceptors of rat aorta by an- thesis, physiological model, ethylene McCully, C. L., see Collins, J. M., 466 alogs of imidazoline, 793 dichloride exposure (rats, mice), 563 McElroy, J. F. and O’Donnell, J. M.: Dis- Lanthanum, magnesium distribution and Locomotion, acute and daily cocaine admin- criminative stimulus properties of movements, aortic smooth muscle istration, behavioral and neurochem- clenbuterol: Evidence for beta adre- (rabbits), 112 ical effects (rats), 485 nergic involvement, 155 Latini, R., see Gambino, M. C., 287 Lohse, M., see Scholz, J., 327 MCI-176, attenuation of ischemic myocar- Laufer, R., Gilon, C., Chorev, M. and Sel- Loomis, C. W., see Sherman, S. E., 319 dial acidosis, coronary artery occlu- inge, Z.: Desensitization with a selec- Lotti, V. J., see Clineschmidt, B. V., 32 sion (dogs), 305 tive agonist discriminates between Lucas, P. C., see Durant, P. A. C., 426 McMillan, D. E., see Schulze, G. E., 178 multiple tachykinin receptors, 639 Lung McNicholas, L. F., Martin, W. R., Sloan, J. Lauwers, see Van Wauwe, J. P., 718 W., clearance of vasoactive drugs (rats), 402 W. and Wala, E.: Percipitation of Lawson, C. F., see Fitzpatrick, F. A., 839 cyclooxygenase products, arachidonic abstinence in nordiazepam- and di- Learning, performance in battery of com- acid metabolism, bronchoconstric- azepam- dependent dogs, 221 plex operant tests, acute effects, te- tion (dogs), 735 Meisch, R. A., see Suzuki, T., 164 trahydrocannabinol (monkeys), 178 fibroblasts, desensitization, guanylate cy- Meisheri, K. D., Cipkus, L. A. and Taylor, Lederis, K., see Muramatsu, I., 625 clase (rats), 413 C. J.: Mechanism of action of minox- Lee, C. see Robertson, D. A., 124 intravenous interferon-a administration, 0., idil sulfate-induced vasodilation: A Lee, T. J.-F., see Shirasaki, Y., 53 pharmacokinetics (rats), 574 role for increased K’ permeability, Leeder, J. S., Cannon, M., Nakhooda, A. parenchyma strips, myotropic activity, 751 and Spielberg, S. P.: Drug metabolite leukotriene B4 (guinea pigs), 839 Meldelson, J. H. and Mello, N. K.: Chronic toxicity assessed in human lympho- tissue glutathione depletion and resyn- alcohol effects on anterior pituitary cytes with a purified, reconstituted thesis, physiological model, ethylene and ovarian hormones in healthy dichloride exposure (rats, mice), 563 cytochrome P-450 system, 956 women, 407 Leficowith, J. B., see Spaethe, S. M., 1088 Luteinizing hormone Mello, N. K., Mendelson, J. H., Bree, M. P. chronic alcohol effects, healthy women, Leibach, F. H., see Miyamoto, Y. 823 and Skupny, A.: Alcohol effects on Leitman, D. C., see Schr#{246}der, H., 413 407 naloxone-stimulated luteinizing hor- naloxone-stimulated, alcohol effects, pro- Leonard, T. B., see Rogers, S. A., 887 mone, follicle-stimulating hormone lactin plasma levels (monkey), 895 Le Peuch, C., see Phaneuf, S., 1042 and prolactin plasma levels in female Lux, F., Brase, D. A. and Dewey, W. L.: Leukotriene B4 rhesus monkeys, 895 Differential effects of subcutaneous essential fatty acid deficiency, hydrone- Mello, N. K., see Meldelson, J. H., 407 and intrathecal morphine adminis- phrosis, suppressed eicosanoid pro- Meltzer, H. Y., see Nash, J. F., Jr., 873 tration on blood glucose in mice: duction (rabbits), 1088 Memory, performance in battery of complex Comparison with intracerebroven- myotropic activity, lung parenchyma operant tests, acute effects, tetrahy- tricular administration, 187 strips, thromboxane A2 (guinea pigs), drocannabinol (monkeys), 178 LY 121555, pharmacological profile of do- 839 Mendelson, J. H., see Mello, N. K., 895 pamine receptor agonists, brain di- Leukotriene D4, -induced vasomotor relax- Menstrual cycle, chronic alcohol effects, pi- alysis (rats), 257 ation, cGMP (dogs), 47 tuitary and ovarian hormones, Lymph node, intravenous interferon-a ad- Levi, R., see Robertson, D. A., 124 healthy women, 407 ministration, pharmacokinetics Levorphanol, kappa-selective opioids and, S-Mephenytoin 4-hydroxylation, oxidative (rats), 574 respiration, behavior (monkeys), 364 metabolism of hexobarbital, liver Lymphocytes, drug metabolite toxicity, cy- Levy, G., see Klockowski, P. M., 508 (humans), 845 tochrome P-450 system (rats), 956 Levy, G., see Wientjes, M. G., 809 Mercury, estimation by chelation, dimer- Ligands captopropane sulfonate (rats), 479 affinity, classification, alpha-i adrenocep- MacKenzie, R. G., see Granneman, J. G., Methacholine, -induced hyperpolarization, tors (bovine), 1060 1068 superior cervical ganglion (rabbits), phencyclidine receptor, cortical neuronal Magnesium, alterations in distribution and 419 injury, NMDA or hypoxia (mice), movements, aortic smooth muscle L-Methionine, alterations of cardiac con- 1081 (rabbits), 112 tractile function (rats), 664 Lindgren, B. R., Grundstr#{246}m, N. and An- Mah, S. C., Opperman, J. R., Baum, H. P. Methoxamine, micturition, spinal vs. pe- dersson, R. G. G.: Effects of an Al- and Hofbauer, K. G.: Biologic re- ripheral pharmacology, adrenergic pha-2 adrenoceptor agonist on angio- sponse to chronic blockade of vaso- system (rats),426 tensin converting enzyme, inhibitor- pressin receptors in Sprague-Dawley N-Methyl-D-aspartate, phencyclidine re- induced hypotension and potentiated rats, 1021 ceptor ligands, cortical neuronal in- allergen-evoked inflammatory skin Mah, S. C. and Hofbauer, K. G.: Evaluation jury (mice), 1081 responses, 932 of the pharmacologic properties of a 3,4-Methylenedioxymethamphetamine, ele- Lis, E. V., see Clineschmidt, B. V., 32 vasopressin antagonist in Brattle- vation of serum prolactin, corticos- Lithium boro rats, 1028 terone concentrations (rats), 873 1988 Index 1119 i-Methyl-4-phenylpyridinium, -induced ef- pellet-induced immunomodulation Myocardial acidosis, attenuation by MCI- fluxes of dopamine and lactate, stria- (mice), 913 176, coronary artery occlusion (dogs), tum (rats), 858 subcutaneous and intrathecal, blood glu- 305 Methyixanthines, chronic caffeine expo- cose (mice), 187 sure, adverse pregnancy outcome supraspinal and spinal opioid analgesia, Nakamura, M., see Shimizu, T., 644, 651 (monkeys), 1048 Mu receptors (mice), 13 Nakane, T., Tsujimoto, G., Hashimoto, K. tolerance and cross-tolerance, discrimi- Meunier, J.-C., see Gairin, J. E., 995 and Chiba, S.: Beta adrenoceptors in Micturition, spinal vs. peripheral pharma- native stimulus (rats), 17 the canine large coronary arteries: cology, adrenergic system (rats), 426 Morre, M., see Keane, P. E., 692, 699 Beta-i adrenoceptors predominate in Miles, E. F., Morris, M. E., Yuen, V., Tang, B. K. and see Cherian, M. G., 479 vasodilation, 936 Miller, D. D., see Lamba-Kanwal, V. K., 793 Pang, K. S.: Competing pathways in Nakhooda, A., see Leeder, J. S., 956 drug metabolism. Miller, L. G., see Raeburn, D., 557 I. Effect of input Nakumura, H., Seto, Y., Motoyoshi, S., Ka- Milne, B., see Sherman, S. E., 319 concentration on the conjugation of dokawa, T. and Sunahara, N.: Re- Milnor, W. R. and Sastre, A.: Cholinergic gentisamide in the once-through in combinant human tumor necrosis receptors and contraction of smooth situ perfused rat liver preparation, factor causes long-lasting and pros- muscle in canine portal vein, 244 614 taglandin-mediated fever, with little vasodilation, Morse, W. H., see Howell, L. L., 364 Minoxidril sulfate, -induced tolerance, in rabbits, 336 mechanism of action, potassium Mosberg, H. I., see Heyman, J. S., 238 Nalmefene, neurological recovery, spinal Motoyoshi, S., see Nakumura, H., 336 permeability (rabbits), 751 cord injury (rats), 742 Miosis, morphine-inducedpupillary fluctua- Mucosa Naloxonazine, dissociation of opioid antin- tions, frequency analysis (rats), 569 amitriptyline effects, ileum electrolyte ociception, central gastrointestinal Mitochondria transport, muscle contractility propulsion (mice), 238 effect of extracellular caldium omission, (guinea pigs), 455 Naloxone hepatocytes (rats), 493 protective action ofhistamine, hydrochlo- effects of morphine administration, blood respiratory toxicity, substrate uptake, rid acid-induced lesions (rats), 632 glucose (mice), 187 cephalosporin antibiotics (rabbits), Mulder, A. H., see Schoffelmeer, A. N. M., -stimulated luteinizing hormone, alcohol 1054 658 effects, prolactin plasma levels (mon- Mitsushio, H., Takashima, M., Mataga, N. Murad, F., see Schroder, H., 413 key), 895 and Tom, M.: Effects of chronic Muramatsu, I., Itoh, H., Lederis, K. and 2-(a-Naphthoyl)ethyltrimethylammonium treatment with trihexyphenidyl and Hollenberg, M. D.: Distinctive ad- iodide, inhibitors of choline acetyl- carbamazepine alone or in combina- tions of epidermal growth factor-uro- transferase (human), 72 tion with haloperidol on substance P gastrone in isolated smooth muscle Narumiya, S., see Ohno, K., 294 content in rat brain: A possible im- preparations from guinea pig stom- Nash, J. F., Jr., Meltzer, H. Y. and Gudel- plication of substance P in affective ach: Differential inhibition by indo- sky, G. A.: Elevation of serum prolac- disorders, 982 methacin, 625 tin and corticosterone concentrations Miyamae, S.-I. and Goto, K.: Effects of Murphy, T. J., see Bylund, D. B., 600 in the rat after the administration of ethylene glycol-bis-(fl-aminoethyl Muscle 3,4-methylenedioxymethamphetam- ether)-N,N’-tetraacetic acid on rab- arterial, serotonin receptors, IC! 169,369 me, 873 bit sinoatrial node cells treated with (calves), 1010 Nathanson, J. A.: Stereospecificity of beta cardiotonic steroids, 706 contractility, ileal electrolyte transport, adrenergic antagonists: R-enantio- Miyamoto, E., see Kushiku, K., 311 amitriptyline effects (guinea pigs), mers show increased selectivity for Miyamoto, Y., Balkovetz, D. F., Ganapathy, 455 beta-2 receptors in ciliary process, 94 V., Iwatsubo, T., Hanano, M. and intravenous interferon-a administration, Navran, S. S., Adair, S. E., Jemelka, S. K., Leibach, F. H.: Effects of phenothia- pharmacokinetics (rats), 574 zines on the N-H exchanger of the Muscle, skeletal, action of diltiazem, excit- Seidel, C. L. and Allen, J. C.: Sodium brush-border membrane from the ation-contraction coupling (frogs), pump stimulation by activation of two proximal small intestine of the rab- 531 alpha adrenergic receptor sub- bit, 823 Muscle, smooth types in canine blood vessels, 608 MK-80i, phencyclidine-like behavioral ef- airway Near, J. A., Bigelow, J. C. and Wightman, fects (pigeons, rats, monkeys), 969 relaxation, peripheral type benzodiaze- R. M.: Comparison of uptake of do- Mohy El-Din, M. M. and Malik, K. U.: pine receptor (guinea pigs), 557 pamine in rat striatal chopped tissue Mechanism of norepinephrine re- volume and contractile response (rab- and synaptosomes, 921 lease elicited by Na-K adenosine bits), 687 Needleman, P., see Spaethe, S. M., 1088 triphosphatase inhibition in the iso- aortic Nelson, S. D., see Thummel, K. E., 129 lated rat kidney: Involvement of volt- cAMP modulation, phorbol ester (rats), Nencini, P., Johanson, C. E. and Schuster, age-dependent Ca channels, 436 1042 C. R.: Sensitization to kappa opioid Mononuclear cells, dapsone metabolism to magnesium distribution, movements mechanisms associated with toler- hydroxylamine, human neutrophils, (rabbits), 112 ance to the anorectic effects of cath- 274 bovine retractor penis muscle, nicotinic inone, 147 Moore, R. D., see Sastry, B. V. R., 72 relaxation, 280 Neocortex, injury after NMDA or hypoxia, Morel, E., see Benavides, J., 1033 contraction of, cholinergic receptors, por- attentuation, phencyclidine receptor Morphine tal vein (dogs), 244 ligands (mice), 1081 cross-tolerance, tolerance, oxymetazo- gallbladder, bombesin, substance P recep- Neomycin, magnesium distribution and line-induced analgesia (rats), 319 tors (dogs), 195 movements, aortic smooth muscle dual action on fetal breathing movements sodium pump stimulation, alpha adrener- (rabbits), 112 (lambs), 537 gid receptor subtypes, blood vessels Neostriatum, muscarinic receptors, adenyl- efficacy and tolerance of narcotic analge- (dogs), 608 ate cyclase inhibition (rats), 658 sics, mu opioid receptor (humans), stomach, epidermal growth factor-urogas- Nephrotoxicity, renal hemodynamics, am- 350 trone actions, indomethacin (guinea photericin B effect (rats), 594 fi-endorphin-induced analgesia, intrathe- pigs), 625 Nerves cal fl-funaltrexamine (mice), 587 vascular, interaction with neutrophils bovine retractor penis muscle, nicotinic -induced pupillary fluctuations, frequency (rats), 102 relaxation, 280 analysis (rats), 569 Mydriasis, morphine-induced pupillary sympathetic, neuroeffector responses, intrathecal, clonidine, blood pressure ef- fluctuations, frequency analysis vasopressin (rabbits), 779 fects (rats), 444 (rats), 569 Neuroblastoma cells, efficacy and tolerance 1120 Index Vol. 245

of narcotic analgesics, mu opioid re- micturition, spinal vs. peripheral phar- Ovulation, chronic alcohol effects, healthy ceptor (humans), 350 macology, adrenergic system (rats), women, 407 Neurochemistry, acute and daily cocaine ad- 426 Owens, L. K., see Sastry, B. V. R, 72 ministration (rats), 485 plasma catecholamine concentrations, Oxazepam, precipitation of abstinence, nor- Neuromuscular junction, acetylcholinester- blood pressure, idazoxan administra- diazepam, diazepam (dogs), 221 am reactivators, nicotinic acetylcho- tion (rats), 265 Oxidative stress, effect of extracellular cal- line receptor ion channel (frogs), 543 release and metabolism, vas deferens cium omission, hepatocytes (rats), Neuropeptides, bombesin and substance P (rats), 81 493, 501 receptors, gallbladder muscle (dogs), time course of tissue changes, sponta- Oximes, acetylcholinesterase reactivators, 195 neously hypertensive and Wistar nicotinic acetylcholine receptor ion Neurotoxicity, effects of antibiotics, neu- Kyoto rats, 24 channel (frogs), 543 ronal calcium uptake (rats), 389 Norman, W. P., see Gatti, P. J., 373 Oxygen, coronary blood flow during exer- Neurotoxins, clostridial, use of pharmaco- Nucleosides, pyrimidine dideoxyribonucbeo- cise, alpha-i adrenergic blockade, logical antagonists (mice), 867 sides, penetration, cerebrospinal prazosin and indoramin (dogs), 232 Neurotransmission, effects of age, cardiac fluid (monkeys), 466 Oxymetazoline, -induced analgesia, toler- sympathetic neuroeffector junction Nucleus accumbens, acute and daily cocaine ance, cross-tolerance to intrathecal (rats), 798 administration, behavioral and neu- morphine (rats), 319 Neurotransmitter rochemical effects (rats), 485 Oxymorphone, opiate agonists and antago- neuronal intracellular calcium concentra- Nucleus tractus solitarius, norepinephrine nists, 14-hydroxydihydromorphinone tions, membrane fluidization (mice), and 5-hydroxyindoleacetic acid, ar- hydrazones (mice), 8 1 terial blood pressure changes (rats), norepinephrine and 5-hydroxyindole- 356 2-PAM, acetylcholinesterase reactivators, acetic acid, arterial blood pressure, nicotinic acetylcholine receptor ion nucleus tractus solitarius (rats), 356 O’Donnell, J. M., see McElroy, J. F., 155 channel (frogs), 543 Neutrophils O’Donnell, S. R., see Wanstall, J. C., 1016 Panagia, V., see Gupta, M. P., 664 dapsone metabolism to hydroxylamine, Ogletree, M. L., see Hedberg, A., 786 Pang, K. S., see Morris, M. E., 614 mononuclear cells, 274 Ohlstein, E. H., see Berkowitz, B. A., 850 Parathyroid hormone, characteristics of interaction with vascular smooth muscle Ohlstein, E. H., see Secrest, R. J., 47 vasodilator effect, new pulsatile per- (rats), 102 Ohno, K., Sakai, T., Fukushima, M., Naru- fused aorta preparation (rats), 723 Newton, J. F., see Rogers, S. A., 887 miya, S. and Fujiwara, M.: Site and Park, B. K., see Crowley, J. J., 513 Nickols, G. A., see Shirasaki, Y., 53 mechanism of growth inhibition by Parker, E. M. and Cubeddu, L. X.: Compar- Nicotine, relaxation, bovine retractor penis prostaglandins. IV. Effect of cyclo- ative effects of amphetamine, phen- muscle, 280 pentenone prostaglandins on cell ylethylamine and related drugs on Nifedipine, calcium channel blockers, recep- cycle progression of G1-enriched dopamine efflux, dopamine uptake tor reserve, vascular tissues (rats), HeLa 53 cells, 294 and mazindol binding, 199 673 Okabe, S., see Takeuchi, K., 632 Passaghe, S., see Gambino, M. C., 287 Nishiuchi, Y., see Baba, A., 299 Okada, M., see Takeuchi, K., 632 Pasternak, G. W., see Williams, C. L., 8 Nishiwaki, H., see Takeuchi, K., 632 Okamoto, T., Kurahashi, K. and Fujiwara, Patel, K. P. and Schmid, P. G.: Vasopressin Nitrate, organic, interaction with thiols M.: Cholinergic transmission in the inhibits sympathetic ganglionic (rats), 524 superior cervical ganglion reinner- Nitroglycerin, thiol-organic nitrate interac- transmission but potentiates sympa- vated by peripheral vagal stump cut neuroeffector responses in tion (rats), 524 thetic below the nodose ganglion in cats, hindlimb vasculature of rabbits, 779 Noble, L. J., see Faden, A. I., 742 990 Nociception Patil, P. N., see Lamba-Kanwal, V. K., 793 Olito, A. C., see Yarosh, C. A., 419 mechanisms of effects, intrathecal sero- Paul, S. M., see Suzdak, P. D., 880 tonin (rats), 905 Olsen, R. W., see McCabe, R. T., 342 Paule, M. G., see Schulze, G. E., 178 patterns of administration, antidepres- Oostveen, J. A., see Richards, I. M., 735 Penis, bovine retractor muscle, nicotinic re- Opiates 280 santa, clomipramine (mice), 963 laxation, Nodose ganglion, cholinergic transmission, agonists and antagonists, analgesic ad- Pentazocine, efficacy and tolerance of nar- superior cervical ganglion reinnerva- tions, 14-hydroxydihydromorphi- cotic analgesics, mu opioid receptor tion (cats), 990 none hydrazones (mice), 8 (humans), 350 Noradrenaline, presynaptic autoinhibition, nalmefene in spinal cord injury (rats), 742 Pentel, P., see Callaham, M., 216 alpha-2 adrenoceptors (rats), 944 Opioids Pentobarbital, isomers of, discriminative Nordiazepam, precipitation of abstinence dissociaton of antinociception, gastroin- stimulus properties (pigeons), 389 (dogs), 221 testinal propulsion, naloxonazine Peny, B., see Benavides, J., 1033 Norepinephrine (mice), 238 Peptidases, membrane-bound, angiotensin adenylate cyclase responsiveness, brown intrathecal morphine and clonidine, blood metabolism, brain (rats), 171 adipose tissue (rats), 1075 pressure effects (rats), 444 Perindopril, inhibition of angiotensin con- discriminative stimulus properties, den- kappa verting enzyme (rats), 950 buterol (rats), 155 effects on respiration, behavior (mon. Perrault, G., see Benavides, J., 1033 effects of age on neurotransmission, car- keys), 364 Pertussis toxin, somatostatin receptor bind- diac sympathetic neuroeffector junc- tolerance, anorectic effects of cathinone ing, multiple effector systems (mice), tion (rats), 798 (rats),147 225 homogeneous population of beta-i adren- Opperman, J. R., see Mah, S. C., 1021 Pettibone, D. J., see Clineschmidt, B. V., 32 oceptors, coronary artery (cows, Organophosphorus agents, acetylcholines- Phaneuf, S., Berta, P., Le Peuch, C., Haiech, guinea pigs, and rabbits), 67 terase reactivators, nicotinic acetyl- J. and Cavadore, J. C.: Phorbol ester 5-hydroxyindoleacetic acid and, arterial choline receptor ion channel (frogs), modulation of cyclic AMP accumu- blood pressure changes, nucleus trac- 543 lation in a primary culture of rat aor- tus solitarius (rats), 356 Osmotic shock, elimination of -y-aminobu- tic smooth muscle cells, 1042 inhibition of contractions, diltiazem, tyric acid, benzodiazepine binding Phencyclidine aorta and pulmonary artery (rats), (rats), 342 -like behavior, MK-801 (pigeons, rats, 1016 Ouabain, mechanism of norepinephrine re- monkeys), 969 mechanism of release, sodium-potassium lease, sodium-potassium adenosine receptor ligands, cortical neuronal injury, adenosine triphosphatase inhibition, triphosphatase inhibition, kidney NMDA or hypoxia (mice), 1081 kidney (rats), 436 (rats), 436 Phenothiazines, effects on Na-H exchan- 1988 Index 1121

ger, brush-border membrane, proxi- alpha-i adrenergic blockade, coronary benzodiazepine mal small intestine (rabbits), 823 blood flow, during exercise (dogs), elimination of ‘y-aminobutyric acid, au- Phenoxybenzamine, calcium channel block- 232 toradiography (rats), 342 ers, receptor reserve, vascular tissues alpha-2 receptor subtypes, antagonist Ro15-45i3, alcohol-induced intoxica- (rats), 673 binding (humans), 600 tion (rats), 880 Phentolamine, micturition, spinal vs. pe- Prefrontal cortex, dopamine terminals, au- cholinergic, contraction of smooth mus- ripheral pharmacology, adrenergic toreceptors (rabbits), 761 cle, portal vein (dogs), 244 system (rats), 426 Pregnancy, adverse outcome, chronic cal- histamine H2, mucosal protective action, Phenylephrine feine exposure (monkeys), 1048 HCL-induced lesions (rats), 632 calcium channel blockers, receptor re- Procaterol, homogeneous population of influence of reserve, calcium channel serve, vascular tissues (rats), 673 beta-i ad.renoceptors, coronary artery blockers, vascular tissues (rats), 673 release of ‘y-aminobutyric acid, clonidine, (cows, guinea pigs, and rabbits), 67 muscarmnic cerebral cortex subregions (rats), 682 Prolactin AF-DX 116, superior cervical ganglion Phenylethylamine, amphetamine and re- chronic alcohol effects, healthy women, (rabbits), 419 lateddrugs, dopamine release, mazin- 407 amitriptyine effects, ileum electrolyte dol binding (rabbits), 199 elevation of, corticosterone, 3,4-methyle- transport (guinea pigs), 455 Phenytoin nedioxymethamphetamine (rats), muscarmnic M-i prophylaxis of cardiotoxicity, experimen- 873 adenylate cyclase inhibition, neostria- tal amitriptyline poisoning (dogs), plasma levels, alcohol effects, luteinizing tum (rats), 658 216 hormone (monkey), 895 prostaglandin synthesis, cholinergic theophylline oxidation and cortisol, aging, Propranolol, discriminative stimulus prop- stimuli (rabbits), 59 healthy men, 513 erties, clenbuterol (rats), 155 nicotinic acetylcholine, ion channel, ace- Phillips, E. T., see Helke, C. J., 41 Prostaglandin H2, receptor binding, SQ 29, tylcholinesterase reactivators (frogs), Phorbol ester, modulation of cAMP accu- 548, platelets (humans), 786 543 mulation, aortic smooth muscle cells Prostaglandins opioid kappa (rats), 1042 growth inhibition, site and mechanism, activity, spontaneously hypertensive Phospholipids, N-methylation, cardiac con- HeLa cells (humans), 294 rats, 460 tractile function, L-methionine pyrogenic properties of tumor necrosis analgesic effects, DPDYN (mice), 995 (rats), 664 factor (rabbits), 336 tolerance, anorectic effects of cathinone Pittaluga, A. and Raiteri, M.: Clonidine en- synthesis, cholinergic stimuli, M2 musca- (rats), 147 hances the release of endogenous y- rinic receptors (rabbits), 59 opioid mu aminobutyric acid through alpha-2 Protein analgesic actions, 14-hydroxydihydro- and alpha-i presynaptic adrenocep- plasma, benzodiazepine binding, cerebral morphinone hydrazones (mice), 8 tors differentially located in rat cer- uptake (rats), 816 efficacy and tolerance, narcotic anal- ebral cortex subregions, 682 stimulatory/regulatory, adenylate cy- gesics (humans), 350 Pituitary, chronic alcohol effects, healthy clase, brown adipose tissue (rats), supraspinal and spinal opioid analgesia women, 407 1068 (mice), 13 Provan, S. D. and Yokel, R. A.: Aluminum Plasma phencyclidine, cortical neuronal injury, uptake by the in situ rat gut prepa- intravenous interferon-a administration, NMDA or hypoxia (mice), 1081 ration, 928 pharmacokinetics (rats), 574 serotonin, IC! 169,369 (calves), 1010 Pupil, morphine-induced fluctuations, fre- prolactin, alcohol effects, luteinizing hor- somatostatin, coupling, multiple effector quency analysis (rats), 569 mone (monkey), 895 systems (mice), 225 Purdy, R. E., Stupecky, G. L. and Coulombe, protein binding, cerebral uptake, benzo- substance P, bombesin, gallbladder mus- P. R.: Further evidence for a homo- diazepines (rats), 816 cle (dogs), 195 geneous population of beta-i-adren- Platelet-activating factor, negative mo- tachykinin, desensitization, selective ag- oceptors in bovine coronary artery, tropic effect, decrease, intracellular onist discrimination (rats), 639 67 sodium activity (guinea pigs), 124 vasopressin, biologic response, chronic Purkinje fibers, V reduction, benzocaine, Platelets blockade (rats), 1021 heart (dogs), 381 oral aspirin, cycbooxygenase activity, por- Reed, D. J., see Thomas, C. E., ion, 501, 493 Puurunen, J., see Scholz, J., 327 tacaval shunt (rats), 287 Thomas, C. E. and Reed, D. J.: Effect Pyridine dinucleotides, ethanol-acetamino- thromboxane Aprostaglandin H2-recep- of extr phen interaction (rats), 129 tors, binding, SQ 29,548 (humans), Reflexes, micturition, spinal vs. peripheral Pyrilamine, histamine H1 antagonists, be- 786 pharmacology, adrenergic system havioral effects, compared to halo- Pohl, L. R., see Kenna, J. G., 1103 (rats), 426 peridol (monkeys), 471 Polymyxins, effects of antibiotics, neuronal Reinnervation, peripheral vagal stump cut Pyrimidine dideoxyribonucleosides, selec- calcium uptake (rats), 389 below nodose ganglion, cholinergic tivity of penetration, cerebrospinal Polyphosphoinositide, alterations in metab- fluid (monkeys), 466 transmission, superior cervical gan- olism, acute ethanol administration glion (cats), 990 (rats), 120 Reisine, T., Wang, H.-L. and Guild, S.: So- Pond, S. M., Waschek, J. A., Mahacha, V., Raeburn, D., Miller, L. G. and Summer, W. matostatin inhibits cAMP-depend- Fielding, R. M., Effeney, D. J. and R.: Peripheral type benzodiazepine ent and cAMP-independent calcium Tozer, T. N.: Nonlinear intestinal receptor and airway smooth muscle influx in the clonal pituitary tumor first-pass metabolism of salicylamide relaxation, 557 cell line AtT-20 through the same in dogs after portacaval transposi- Raffa, R. B., see Vaught, J. L., 13 receptor population, 225 tion, 291 Raij, L., see Tollins, J. P., 594 Reiss, D. R., see Clineschmidt, B. V., 32 Poplack, D. G., see Collins, J. M., 466 Raiteri, M., see Pittaluga, A., 682 Reproduction, chronic alcohol effects, pitui- Porreca, F., see Heyman, J. S., 238 Ranitidine, inhibition of acetaminophen tary and ovarian hormones, healthy Potassium conjugation, hepatotoxicity, 887 women, 407 magnesium distribution and movements, Rao, K. S., see Alkondon, M., 543 Respiration aortic smooth muscle (rabbits), 112 Rapoport, S. I., see Greig, N. H., 574,581 effects of levorphanol, kappa-selective permeability, vasodilation, minoxidril Ray-Prenger, C., see Bylund, D. B., 600 opioids (monkeys), 364 sulfate-induced (rabbits), 751 Receptors fetal breathing movements, dual action of Potassium current, cardiac, blockade, ICS adrenergic, see Adrenoceptors morphine (lambs), 537 205-930 (guinea pigs), 773 alpha-2 subtypes, antagonist binding (hu- Retinoic acid Prazosin mans), 600 efficacy and tolerance of narcotic analge- 1122 Index Vol. 245

sids, mu opioid receptor (humans), diac potassium, sodium and calcium Shippenberg, T. S., see Emmett-Oglesby, M. 350 currents, 773 W., 17 inhibited metabolism, ketoconazole Scholz, H., see Scholz, J., 327 Shirasaki, Y., Kolm, P., Nickols, G. A. and (hamsters), 718 Scholz, J., Schaefer, B., Schmitz, W., Lee, T. J.-F.: Endothelial regulation Reuhl, K. R., see Gilbert, S. G., 1048 Scholz, H., Steinfath, M., Lohse, M., ofcyclic GMP and vascular responses Rice, D. C., see Gilbert, S. G., 1048 Schwabe, U. and Puurunen, J.: Al- in hypertension, 53 Richards, I. M., Griffin, R. L., Oostveen, J. p/ia-i adrenoceptor-mediated posi- Shreeve, S. M.: Classification of bovine aor- A., Elfring, G. and Conder, G. A.: tive inotropic effect and inositol tris- tic alpha-i adrenoceptors by the cri- Role of cyclooxygenase products of phosphate increase in mammalian teria of ligand affinity and molecular arachidonic acid metabolism in As- heart, 327 mass, 1060 cans antigen-induced bronchocon- Schroder, H., Leitman, D. C., Bennett, B. Shunt, portacaval, oral aspirin, cyclooxy- striction in sensitized dogs, 735 M., Waldman, S. A. and Murad, F.: genase activity (rats), 287 Rimele, T. J., Sturm, R. J., Adams, L. M., Glyceryl trinitrate-induced desensi- Sibley, R. K., see Tune, B. M., 1054 Henry, D. E., Heaslip, R. J., Weich- tization of guanylate cyclase in cul- Simiand, J., see Keane, P. E., 692 man, B. M. and Grimes, D.: Interac- tured rat lung fibroblasts, 413 Simpson, L. L.: The use of pharmacologic tion of neutrophils with vascular Schulze, G. E., McMillan, D. E., Bailey, J. antagonists to deduce commonalities smooth muscle: Identification of a R., Scallet, A., Ali, S. F., Slikker, W., of biologic activity among clostridial neutrophil-derived relaxing factor, Jr. and Paule, M. G.: Acute effects of neurotoxins, 867 102 -9-tetrahydrocannabinol in rhesus Singer, E. S., see Valenta, B., 944 Ro15-4513, effects on alcohol-induced in- monkeys as measured by perform- Sinoatrial node cells, effects of EGTA, car- toxication (rats), 880 ance in a battery of complex operant diotonic steroids (rabbits), 706 Roberts, J., see Daly, R. N., 798 tests, 178 Sj#{246}strand, N. 0., see Klinge, E., 280 Robertson, D. A., Wang, D.-Y., Lee, C. 0. Schumaker, H., see Callaham, M., 216 SK&F 38393, pharmacological profile of do- and Levi, R.: Negative inotropic ef- Schuster, C. R., see Nencini, P., 147 pamine receptor agonists, brain di- fect of platelet-activating factor: As- Schwabe, U., see Scholz, J., 327 alysis (rats), 257 sociation with a decrease in intracel- Schwartz, A., see Walsh, K. B. SK&F 86466, pulmonary clearance (rats), lular sodium activity, 124 Schwartz, J. S., see Bache, R. J., 232 402 Rogers, S. A., Newton, J. F., Dent, J. G. and Secobarbital, isomers of, discriminative SK&F 102698, effects on catecholamines Leonard, T. B.: Inhibition by raniti- stimulus properties (pigeons), 389 and blood pressure (rats), 850 dine of acetaminophen conjugation Secrest, H. J., Ohlstein, E. H. and Chapnick, SK&F 105494, antidiuretic hormone antag- and its possible role in ranitidine po- B. M.: Relationship between LTD4- onist (monkeys), 211 tentiation of acetaminophen-induced induced endothelium-dependent vas- Skinner, C., see Kalivas, P. W., 485 hepatotoxicity, 887 omotor relaxation and cGMP, 47 Skupny, A., see Mello, N. K., 895 Rollema, H., Kuhr, W. G., Kranenborg, G., Seidel, C. L., see Navran, S. S., 608 Slattery, J. T., see Thummel, K. E., 129 De Vries, J. and Van den Berg, C.: Seizures, tetrazepam, psychopharmacologi- Slikker, W., Jr., see Schulze, G. E., 178 MPP-induced effluxes of dopamine cal profile (rats, mice), 692, 699 Sloan, J. W., see McNicholas, L. F., 221 and lactate from rat striatum have Selinge, Z., see Laufer, R., 639 Smith, B. R., see Gombar, C. T., 402 similar time courses as shown by in Serotonin Sodium vivo brain dialysis, 858 arterial 5-hydroxytryptamine2 receptor magnesium distribution and movements, Ropchak, T. G., see Eisenhofer, G., 81 system, ICI 169,369 (calves), 1010 aortic smooth muscle (rabbits), 112 Rosen, M. R., see Spinelli, W., 381 elevation of serum prolactin, corticoster- negative inotropic effect, platelet-activat- Roth, J. S., see Collins, M., 466 J. one, 3,4-methylenedioxymetamphe- ing factor (guinea pigs), 124 tamine (rats), 873 Sodium current intrathecal, mechanisms of effects, noci- cardiac, blockade, ICS 205-930 (guinea S-8666, renal action (rats), 644, 651 ception and blood pressure (rats), 905 pigs), 773 Sacksen, I., see Faden, A. I., 742 norepinephrine and 5-hydroxyindole- effects of EGTA, sionatrial node cells, Sad#{234}e,W., see Yu, V. C., 350 Sakai, T., see Ohno, K., 294 acetic acid, arterial blood pressure cardiotonic steroids (rabbits), 706 Salicylamide, nonlinear intestinal first-pass changes, nucleus tractus solitarius Sodium-hydrogen exchanger, see Na-W metabolism, portacaval transposition (rats), 356 exchanger (dogs), 291 Seto, Y., see Nakumura, H., 336 Sodium-potassium adenosine triphospha- Sastre, A., see Milnor, W. R., 244 Seven, C., Grider, J. R. and Makhlouf, G. tase, inhibition, norepinephrine re- Sastry, B. V. R., Jaiswal, N., Owen, L. K., M.: Identification of separate bom- lease, kidney (rats), 436 Janson, V. E. and Moore, R. D.: besin and substance P receptors on Sodium-potassium pump, alpha adrenergic 2-(a-Na- isolated muscle cells from canine receptor subtypes, blood vessels phthoyl)ethyltrimethylammonium gallbladder, 195 (dogs), 608 iodide and its /3-isomer: New selec- Shear, N. H., see Uetrecht, J., 274 Solomon, R. E. and Gebhart, G. F.: Intrathe- tive, stable and flourescent inhibitors Sherman, S. E., Loomis, C. W., Milne, B. cal morphine and clonidine: Antino- of choline acetyltransferase, 72 and Cervenko, F. W., Tolerance to ciceptive tolerance and cross-toler- Satoh, H., see Kenna, J. G., 1103 intrathecal oxymetazoline-induced ance and effects on blood pressure, Scallet, A., see Schulze, G. E., 178 analgesia, with paradigm-dependent 444 Scatton, B., see Benavides, J., 1033 cross-tolerance to intrathecal mor- Solomon, R. E. and Gebhart, G. F.: Mecha- SCH 34826, pharmacology (mice), 829 phine, 319 nisms of effects of intrathecal sero- Schaefer, B., see Scholz, J., 327 Shetty, S. S. and Weiss, G. B.: Alterations tonin on nociception and blood pres- Schmid, P. G., see Patel, K. P., 779 in Mg distribution and movements sure in rats, 905 Schmitz, W., see Scholz, J., 327 in rabbit aortic smooth muscle, 112 Somatostatin, receptors, coupling, multiple Schneider, D. E., see Bjornsson, T. D., 804 Shimizu, T., Nakamura, M. and Imai, M.: effector systems (mice), 225 Schoffelmeer, A. N. M., Hogenboom, F. and Renal action of a novel uricosuric Soncrant, T. T., see Greig, N. H., 574, 581 Mulder, A. H.: M-i and M-2 musca- diuretic, 5-8666. II. Effects on C1 Spaethe, S. M., Freed, M. S., De Schryver- rinic receptor-mediated inhibition of and urate transport in isolated per- Kecskemeti, K., Lefkowith, J. B. and dopamine-sensitive adenylate cyclase fused rabbit renal tubules, 651 Needleman, P.: Essential fatty acid in rat neostriatum: a permissive role Shimizu, T., Nakamura, M. and Imai, M.: deficiency reduces the inflammatory for D-2 dopamine receptors, 658 Renal action of a novel uricosuric cell invasion in rabbit hydrone- Scholtysik, G., Imoto, Y., Yatani, A. and diuretic, S-8666. I. Clearance and tu- phrosis resulting in suppression of Brown, A. M.: 5-Hydroxytryptamine bular microinjection studies in rats, the exaggerated eicosanoid produc- antagonist ICS 205-930 blocks car- 644 tion, 1088 1988 Index 1123

Spealman, R. D., see Bergman, J., 471 Suzuki, T., George, F. R. and Meisch, R. A.: lated hepatocytes. I. Induction of ox- Spielberg, S. P., see Leeder, J. S., 956 Differential establishment and main- idative stress and cell injury, 493 Spinal cord tenance of oral ethanol reinforced be- Thromboxane, cyclooxygenase products, ar- intrathecal morphine and clonidine, blood havior in Lewis and Fischer 344 achidonic acid metabolism, broncho- pressure effects (rats), 444 inbred rat strains, 164 constriction (dogs), 735 thyrotropin-releasing hormone receptor Sweeney, B. M., see Clineschmidt, B. V., 32 Thromboxane A2 activation, blood pressure, sympa- Sympathetic ganglia, increment of calmod- myotropic activity of leukotriene B4, lung thetic tone (rats), 41 ulin, enhancement, non-nicotinic re- parenchyma strips (guinea pigs), 839 traumatic injury, neurological recovery, sponses (dogs), 311 SQ 29,548 binding, platelets (humans), nalmefene (rats), 742 Sympathetic nerves 786 Spinelli, W., Danilo, P., Jr. and Rosen, M. cardiac neuroeffector junction, effects of Thummel, K. E., Slattery, J. T. and Nelson, R.: Reduction of Vmx by QX-314 and age, neurotransmission (rats), 798 S. D.: Mechanism by which ethanol benzocaine in neonatal and adult ca- sympathetic neuroeffector responses, vas- diminishes the hepatotoxicity of ad- nine cardiac Purkinje fibers, 381 opressin, hindlimb vasculature (rab- etaminophen, 129 Spleen bits), 779 Thyrotropin-releasing hormone receptor, intravenous interferon-a administration, Sympathetic nervous system, thyrotropin- activation in spinal cord, vasculature, pharmacokinetics (rats), 574 releasing hormone receptor activa- adrenals (rats), 41 norepinephrine content in tissues, time tion, spinal cord, blood pressure Timolol, stereoselectivity, beta receptors course (rats), 24 (rats), 41 (rabbits), 94 SQ 29,548, binding to thromboxane A2, Synaptic potentials, muscarinic responses Tolerance, cross-tolerance and, discrimina- prostaglandin H2-receptors, platelets ofAF-DX 116 (rabbits), 419 tive stimulus properties, fentanyl and (humans), 786 Synaptosomes morphine (rats), 17 ST-9i, micturition, spinal vs. peripheral comparison of uptake of dopamine, stria- Tollins, J. P. and Raij, L.: Adverse effect of pharmacology, adrenergic system tal chopped tissue (rats), 921 amphotericin B administration on (rats), 426 release of -y-aminobutyric acid, clonidine, renal hemodynamics in the rat. Neu- Stassen, F. L., see Brooks, D. P., 211 cerebral cortex subregions (rats), 687 rohumoral mechanisms and influ- ence of calcium channel blockade, Stavric, B., see Gilbert, S. G., 1048 Szeto, H. H., Zhu, Y.-S., Umans, J. G., Steinfath, M., see Scholz, J., 327 Dwyer, G., Clare, S. and Amione, J.: 594 see Mitsushio, H., 982 Steroids, cardiotonic, EGTA effects, sinoa- Dual action of morphine on fetal Toni, M., movements, 537 Tozer, T. N., see Pond, S. M., 291 trial node cells (rabbits), 706 breathing Trihexyphenidyl, effects of chronic treat- Stitzel, R. E., see Donohue, S. J., 24 ment, substance P, brain (rats), 982 Stomach, epidermal growth factor-urogas- Tachykinins Trimebutine maleate, local actions, small trone actions, indomethacin (guinea bombesin and substance P receptors, gall- intestine (dogs), 1002 pigs), 625 bladder muscle (dogs), 195 Tripelennamine, histamine H1 antagonists, St-Onge-Brault, G., see Gascon-Barr#{233}, M., multiple receptors, desensitization, selec- behavioral effects, compared to halo- 975 tive agonist discrimination (rats), 639 peridol (monkeys), 471 Striatum, i-methyl-4-phenylpyridinium-in- Takashima, M., see Mitsushio, H., 982 Tseng, L.-F., see Suh, H. H., 587 duced effluxes, dopamine, lactate Takeuchi, K., Nishiwaki, H., Okada, M. and Tsujimoto, G., see Nakane, T., 936 (rats), 858 Okabe, S.: Mucosal protective action Tumor necrosis factor, pyrogenic properties Stupecky, G. L., see Purdy, R. E., 67 of histamine against gastric lesions (rabbits), 336 Storm, R. J., see Rimele, T. J., 102 induced by HC1 in rats: Importance Tune, B. M., Sibley, R. K. and Hsu, C.-Y.: Substance P of antigastric motor activity me- The mitochondrial respiratory toxic- effects ofchronic treatment, trihexyphen- diated by H2-receptors, 632 ity of cephalosporin antibiotics. An idyl and carbamazepine, brain (rats), Talmaciu, R. K., see Hoffman, I. S., 761 inhibitory effect on substrate uptake, 982 Tanaka, C., see Taniyama, K., 250 1054 multiple tachykinin receptors, desensiti- Tanda, G., see Imperato, A., 257 Tyrosine hydroxylase, acute and daily co- zation, selective agonist discrimina- Tang, B. K., see Morris, M. E., 614 caine administration, behavioral and tion (rats), 639 Taniyama, K., Hashimoto, S., Hanada, S. neurochemical effects (rats), 485 receptors, bombesin, gallbladder muscle and Tanaka, C.: Benzodiazepines and (dogs), 195 barbiturate potentiate the pre- and U-50,488H, kappa opioid activity, sponta- Suh, H. H. and Tseng, L.-F.: Intrathecal fi- postsynaptic -y-aminobutyric acid neously hypertensive rats, 460 funaltrexamine antagonizes intracer- (GABA)A receptor-mediated re- Uemura, A., see Baba, A., 299 ebroventricular 9-endorphin- but not sponse in the enteric nervous system Uetrecht, J., Zahid, N., Shear, N. H. and morphine-induced analgesia in mice, of guinea pig small intestine, 250 Biggar, W. D.: Metabolism of dap- 587 Taste, aversion, conflict model, anxiolytic sone to a hydroxylamine by human Sulfation drugs (rats), 137 neutrophils and mononuclear cells, conjugation of gentisamide, competing Taylor, C. J., see Meisheri, K. D., 751 274 pathways (rats), 614 Terbutaline, micturition, spinal vs. periph- Umans, J. G., see Szeto, H. H., 537 nonlinear first-pass metabolism, salicyl- eral pharmacology, adrenergic sys- Urate, renal action ofS-8666 (rats), 644, 651 amide, portacaval transposition tem (rats), 426 Urogastrone, epidermal growth factor, (dogs), 291 Tetracyclines, neuronal calcium uptake smooth muscle from stomach, indo- Summer, W. R., see Raeburn, D., 557 (rats), 389 methacin (guinea pigs), 625 Sun, G. Y., see Chandrasekhar, R., 120 Tetrahydrocannabinol, acute effects, com- Sung, C. P., see Berkowitz, B. A., 850 plex operant tests (monkeys), 178 Sunahara, N., see Nakumura, H., 336 Tetrazepam, psychopharmacological profile Vacca, J., see Clineschmidt, B. V., 32 Superior cervical ganglion (rats, mice), 692, 699 Vagus nerve, superior cervical ganglion rein- cholinergic transmission, reinnervation, Tetrodotoxin, effects of EGTA on sinoatrial nervation, cholinergic transmission, peripheral vagal stump (cats), 990 node cells, cardiotonic steroids (rab- nodose ganglion (cats), 990 muscarinic responses, AF-DX 116 (rab- bits), 706 Valenta, B., Drobny, H. and Singer, E. S.: bits), 419 Theophylline, oxidation, aging and drug in- Presynaptic autoinhibition of central Suzdak, P. D., Paul, S. M. and Crawley, J. teractions, healthy men, 513 noradrenaline release in vitro: Oper- N.: Effects of RoiS-45i3 and other Thiols, interaction oforganic nitrates (rats), ational characteristics and effects of benzodiazepine receptor inverse ago- 524 drugs acting at alpha-2 adrenoceptors nists on alcohol-induced intoxication Thomas, C. B. and Reed, D. J.: Effect of in the presence of uptake inhibition, in the rat, 880 extracellular Ca omission on iso- 944 1124 Index Vol. 245

Van den Berg, C., see Rollema, H., 858 Ventral mesencephalon, amphetamine in- Wientjes, M. G. and Levy, G.: Nonlinear Vanhoutte, P. M., see Harker, C. T., 89 jection, sensitivity, peripheral am- pharmacokinetics of aspirin in rats, Van Nijen, G., see Van Wauwe, J. P., 718 phetamine and cocaine (rats), 1095 809 Van Wauwe, J. P., Coene, M.-C., Goossens, Verapamil Wightman, H. M., see Near, J. A., 921 J., Van Nijen, G., Cools, W. and Lau- calcium channel blockers, receptor re- Wilkinson, G. H., see Jones, D. R., 816 wers, W.: Ketoconazole inhibits the serve, vascular tissues (rats), 673 Wilkinson, G. H., see Knodell, H. G., 845 in vitro and in vivo metabolism of all- effects of EGTA, sinoatrial node cells, Williams, C. L., Bodnar, R J., Clark, J. E., trans-retinoic acid, 718 cardiotonic steroids (rabbits), 706 Hahn, E. F., Burks, T. F. and Paster- Varoquaux, 0., see Eschalier, A., 963 renal hemodynamics, amphotericin B ef- nak, G. W.: Irreversible opiate ago- Vascular tone, cyclic GMP, endothelial reg- fect (rats), 594 nists and antagonists. IV. Analgesic ulation, hypertension (rats), 53 Vestal, R. E., see Crowley, J. J., 513 actions of i4-hydroxydihydromor- Vas deferens, release and metabolism of Viseskul, V., see Goldberg, M. P., 1081 phinone hydrazones, 8 norepinephrine (rats), 81 Vitamin D3, liver extraction, route of deliv- Williams, C. L., see Heyman, J. S., 238 Vasodilation ery (rats), 975 Winger, G. D., see Kook, W., 969 beta adrenoceptors, large coronary arter- Vitamin E, effect of extracellular calcium Woods, J. H., see Kook, W., 969 ies (dogs), 936 omission, hepatocytes (rats), 493 Wozniak, K. M., see Greig, N. H., 574 minoxidril sulfate-induced, mechanism of action, potassium permeability (rab- Yaksh, T. L., see Durant, P. A. C., 426 bits), 751 Wala, E., see McNicholas, L. F., 221 Yarosh, C. A., Olito, A. C. and Ashe, J. H.: Vasopressin Waldman, S. A., see Schroder, H., 413 AF-DX 116: A selective antagonist of inhibition of sympathetic ganglionic Walsh, K. B., Bryant, S. H. and Schwartz, the slow inhibitory postsynaptic po- transmission, sympathetic neuroef- A.: Action of diltiazem on excitation- tential and methacholine-induced fector responses, hindlimb vascula- contraction coupling in bullfrog skel- hyperpolarization in superior cervical tore (rabbits), 779 etal muscle fibers, 531 ganglion of the rabbit, 419 receptors, biologic response, chronic Wamsley, J. K., see McCabe, R. T., 342 Yatani, A., see Scholtysik, G. 773 blockade (rats), 1021 Wang, D.-Y., see Robertson, D. A., 124 Yezuita, J. P., see McCabe, H. T., 342 SKF 105494, antidiuretic hormone antag- Wang, H.-L., see Reisine, T., 225 Yohimbine, micturition, spinal vs. periph- onist (monkeys), 211 Wanstall, J. C. and O’Donnell, S. R.: Inhi- eral pharmacology, adrenergic sys- Vasopressin antagonist, evaluation of phar- bition of norepinephrine contrac- tem (rats), 426 macologic properties (rats), 1028 tions by diltiazem on aorta and pul- Yokel, R. A., see Provan, S. D., 928 Vaught, J. L., Mathiasen, J. R. and Haifa, monary artery from young and aged Yu, V. C. and Sad#{233}e,W.: Efficacy and tol- R. B.: Examination of the involve- rats: Influence of alpha-adrenoceptor erance of narcotic analgesics at the ment of supraspinal and spinal mu reserve, 1016 mu opioid receptor in differentiated and delta opioid receptors in analge- Waschek, J. A., see Pond, S. M., 291 human neuroblastoma cells, 350 sia using the mu receptor deficient Weber, B., see Kalivas, P. W., 1095 Yuen, V., see Morris, M. E., 614 mouse, 13 Weichman, B. M., see Rimele, T. J., 102 Vein Weiss, G. B., see Shetty, S. S., 112 Zahid, N., see Uetrecht, J., 274 portal, cholinergic receptors, smooth mus- Wenger, G. R.: Discriminative stimulus Zhu, Y.-S., see Szeto, H. H., 537 cle contraction (dogs), 244 properties of the isomers of pento- Zivkovic, B., see Benavides, J., 1033 route of delivery, liver extraction, vitamin barbital and secobarbital in pigeons, Zolpidem, interaction with benzodiazepine D3 (rats), 975 389 binding sites, brain (mice), 1033