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The Editor of the Journal of Pharmacology & Experimental Therapeutics wishes to express appreciation to the following colleagues who acted as Guest Editors for Specific Fields in 1987. Martin W. Adler Frank R. Goodman Elaine Sanders-Bush Lewis Aronow Robert Z. Gussin Lewis E. Seiden C. Paul Bianchi Conan Kornetsky Theodore J. Torphy Allan H. Conney Donald J. Jenden John L. Skosey Theodore J. Cicero Robert M. Joy Larry G. Stark Charles R. Craig Louis Lemberger Norman Weiner Gerard L. Gebber Benedict R. Lucchesi Wallace D. Winters James W. Gibb Donald V. Priola Dixon M. Woodbury Dora B. Goldstein Additionally, sincere thanks are due to 724 of our colleagues not on the Editorial Advisory Board who reviewed articles for the Journal in 1987. Their contributions are acknowledged individually in the Annual Report of The Journal to The Board of Publications Trustees of The American Society for Pharmacology and Experimental Therapeutics. INDEX Volume 245, April-June, 1988 A23187, effect ofextracellularcalcium omis- classification, ligand affmity and mo- -induced intoxication, effects of Ro15- sion, hepatocytes (rats), 493 lecular mass (bovine), 1060 4513 (rats), 880 Abhold, R. H. and Harding, J. W.: Metabo- imidazoline analogs, aorta (rats), 793 Mi, S. F., see Schulze, G. E., 178 lism of angiotensins II and III by inotropic positive effect, inositol tris- Alkondon, M., Rao, K. S. and Albuquerque, membrane-bound peptidases from phosphate increase in heart (rats), E. X.: Acetylcholinesterase reactiva- rat brain, 171 327 tom modify the functional properties Abiko, Y., see Hara, Y., 305 prazosin and indoramin, coronary of the nicotinic acetylcholine recep- Acetaminophen blood flow (dogs), 232 tor ion channel, 543 diminuition of hepatotoxicity, ethanol alpha-2 Allbee, W. E., see Kachur, J. F., 455 (rats), 129 effects of agonist, angiotensin convert- Allen, J. C., see Navran, S. S., 608 drug metabolite toxicity, human lympho- ing enzyme (guinea pigs), 932 Allescher, H.-C., see Daniel, E. E., 1002 cytes, cytochrome P-450 (rats), 956 idazoxan administration, blood pres- Aluminum, uptake, gut preparation (rats), inhibition ofconjugation, ranitidine, hep- sure (rats), 265 928 atotoxicity, 887 peripheral-acting antagonist (rats), 32 Amino acids Acetylcholinesterase presynaptic autoinhibition, central nor- excitatory muscarimc responses of AF-DX 116, su- adrenaline release (rats), 944 cAMP accumulation, role of chloride perior cervical ganglion (rabbits), 419 receptor subtypes, antagonist binding (guinea pigs), 299 reactivators, nicotinic acetylcholine re- (humans), 600 phencyclidine-like behavior, MK-801 ceptor ion channel (frogs), 543 alpha and beta, brown fat adenylate cy- (pigeons, rats, monkeys), 969 N-Acetylcysteine, pharmacologic interac- clase, norepinephrine (rats), 1075 Aminobenzotriazole, pulmonary clearance, tion, organic nitrates with thiols beta vasoactive drugs (rats), 402 (rats), 524 discriminative stimulus, clenbuterol -y-Aminobutyric acid Adair, S. E., see Navran, S. S., 608 (rats), 155 effects of Ro15-4513, intoxication, alco- Adams, L. M., see Rimele, T. J., 102 large coronary arteries (dogs), 936 hol-induced (rats), 880 Adejare, A., see Lamba-Kanwal, V. K., 793 stereospecificity, antagonists (rabbits), elimination of, osmotic shock (rats), 342 Adenosine triphosphatase, sodium-potas- 94 enhanced release by clonidine, alpha sium, norepinephrine release, kidney beta-i, homogeneous population, bovine adrenoceptors, cerebral cortex subre- (rats), 436 coronary artery (cows, guinea pigs, gions (rats), 682 Adenylate cyclase and rabbits), 67 receptor response, benzodiazepines, en- inhibition, muscarinic receptors, neos- AF-DX 1 16, muscarinic responses, superior teric nervous system (guinea pigs), triatum (rats), 658 cervical ganglion (rabbits), 419 250 responsiveness, norepinephrine, brown Affective disorders, effects of trihexypheni- Aminoglycosides, effects of antibiotics, neu- adipose tissue (rats), 1075 dyl and carbamazepine, substance P ronal calcium uptake (rats), 389 somatostatin receptor coupling, multiple and haloperidol, brain (rats), 982 Amione, J., see Szeto, H. H., 537 effector systems (mice), 225 Aging Amitriptyline stereoselectivity, ocular beta receptors effect of phenytoin and smoking, theoph- antihistaminic and antimuscarinic ef- (rabbits), 94 ylline oxidation and cortisol, healthy fects, ileal electrolyte transport, mus- stimulatory regulatory protein, neural men, 513 cle contractility (guinea pigs), 455 modulation, brown adipose tissue effects on neurotransmission, cardiac experimental poisoning, phenytoin pro- (rats), 1068 sympathetic neuroeffector junction phylaxis, cardiotoxicity (dogs), 216 Adgate, L., see Atchison, W. D., 394 (rats), 798 Amphetamine Adipose tissue inhibition of norepinephrine contrac- phenylethylamine and related drugs, do- brown tions, aorta and pulmonary artery, pamine release, mazindol binding adenylate cyclase, stimulatory regula- diltiazem (rats), 1016 (rabbits), 199 tory protein (rats), 1068 Ahmad, S., see Daniel, E. E., 1002 ventral mesencephalon injection, sensi- norepinephrine, adenylate cyclase re- AHR 11325, histamine H, antagonists, be- tivity, peripheral amphetamine and sponsiveness (rats), 1075 havioral effects, compared to halo- cocaine (rats), 1095 Adler, M. W., see Gochin, P. M., 569 peridol (monkeys), 471 Amphotericin B, adverse effect on renal Adrenal glands, norepinephrine content in Airway hemodynamics (rats), 594 tissues, time course (rats), 24 smooth muscle relaxation, peripheral type Analgesia Adrenoceptors benzodiazepine receptor (guinea effects of DPDYN (mice), 995 alpha pigs), 557 -endorphin-induced, intrathecal fl-fun- clonidine, ‘y-axninobutyric acid release smooth muscle volume and contractile re- altrexamine (mice), 587 (rats), 682 sponse (rabbits), 687 oxymetazoline-induced, tolerance, cross- cooling, central ear artery (rabbits), 89 Alaranta, S., see Klinge, E., 280 tolerance to intrathecal morphine inhibited norepinephrine contractions, Albrightson-Winslow, C. R., see Brooks, D. (rats), 319 diltiazem (rats), 1016 P., 211 pharmacology of SCH 34826 (mice), 829 receptor reserve, calcium channel Albuquerque, E. X., see Alkondon, M., 543 supraspinal and spinal opioid, Mu recep- blockers in vascular tissues (rats), Alcohol tor (mice), 13 673 chronic effects, pituitary and ovarian hor- Analgesics sodium pump stimulation, blood vessels mones, healthy women, 407 narcotic, efficacy and tolerance, mu (dogs), 608 effects on naloxone-stimulated luteiniz- opioid receptor (humans), 350 spinal vs. peripheral pharmacology, ing hormone, follicle-stimulating opiate agonists and antagonists, i4-hy- micturition (rats), 426 hormone, prolactin plasma levels droxydihydromorphinone hydra- alpha-i (monkey), 895 zones (mice), 8 1111 1112 Index Vol. 245 Andersen, M. E., see D’Souza, R. W., 563 sponse in airway tissue. Isometric acute and daily cocaine administration Andersson, R. G. G., see Lindgren, B. R., versus isotonic measurement, 687 (rats), 485 932 Artery effects of levorphanol, kappa-selective Anesthetics caudal, norepmephrine content in tissues, opioids (monkeys), 364 neuronal intracellular calcium concentra- time course (rats), 24 genetic factors in ethanol reinforcement tions, membrane fluidization (mice), central ear, cooling (rabbits), 89 (rats), 164 1 coronary performance in battery of complex oper- reduction of V,,,,,,, benzocaine, cardiac beta adrenoceptors (dogs), 936 ant tests, acute effects, tetrahydro- Purkinje fibers (dogs), 381 homogeneous population, beta-i adren- cannabinol (monkeys), 178 Angiotensin converting enzyme oceptors (cows, guinea pigs, and rab- phencyclidine-like, MK-801 (pigeons, apha-2 adrenoceptor agonist, clonidine, bits), 67 rats, monkeys), 969 inflammation (guinea pigs), 932 ischemic myocardial acidosis, MCI-176 Benavides, J., Peny, B., DuBois, A., Per- inhibition by perindopril (rats), 950 (dogs), 305 rault, G., Morel, E., Zivkovic, B. and Angiotensins II and III, metabolism by mesenteric Scatton, B.: In vivo interaction of membrane-bound peptidases, brain leukotriene D4 vasomotor relaxation, zolpidem with central benzodiaze- cGMP (dogs), 47 (rats), 171 pine (BZD) binding sites (as labeled norepinephrine content in tissues, time Antagonists, beta adrenergic, stereospecific- by [3H]RO 15-1788) in the mouse course (rats), 24 ity, ciliary process (rabbits), 94 brain. Preferential affmity of zolpi- vasodilation, minoxidril sulfate-in- Antibiotics dem for the w, (BZD,) subtype, 1033 duced (rabbits), 751 cephalosporin, mitochondrial respiratory Bennett, B. M., see Schroder, H., 413 pulmonary, inhibited norepinephrine toxicity (rabbits), 1054 Benzocaine, reduction of V, cardiac Pur- contractions, diltiazem (rats), 1016 effects on calcium uptake, isolated nerve kinje fibers (dogs), 381 route of delivery, liver extraction, vitamin terminals (rats), 389 Benzodiazepines D3 (rats), 975 Anticonvulsants, tetrazepam, psychophar- binding sites, interaction of zolpidem, Ashe, J. H., see Yarosh, C. A., 419 macological profile (rats, mice), 692, brain (mice), 1033 Aspirin 699 nonlinear pharmacokinetics (rats), 809 cerebral uptake, lipophilicity, plasma pro- Antidepressants tein binding (rats), 816 oral vs. i.v., inhibitor of cyclooxygenase discriminative stimulus properties, den- effect of experimental hypovolemia, des- activity, portacaval shunt (rats), 287 buterol (rats), 155 pyrogenic properties of tumor necrosis methyldiazepam (rats), 508 patterns of administration, antinocicep- factor (rabbits), 336 GABAA receptor response, enteric nerv- tive action,