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Project Description PROJECT Bromley Little Theatre A3 posters DESCRIPTION Posters to advertise a variety of different plays being performed at the theatre. IN THE AN AMATEUR PRODUCTION BY ARRANGEMENT WITH SAMUEL FRENCH LTD BAR AN AMATEUR PRODUCTION BY ARRANGEMENT WITH SAMUEL FRENCH LTD Website graphics CONTAINS VERY STRONG LANGUAGE AND SEXUAL REFERENCES THROUGHOUT for each play were also created. AN AMATEUR PRODUCTION BY ARRANGEMENT WITH SAMUEL FRENCH LTD BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB BROMLEY LITTLE THEATRE, IN THE BAR, NORTH STREET, BROMLEY KENT BR1 1SB BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 Members: £8 / Non-members: £12 • Booking opens to non-members on 8th November Members: £8 / Non-members: £12 • Booking opens to non-members on 13th Sept Members: £7 / Members’ guests: £10 • Booking opens on 22 August Tickets also available from the Churchill Theatre box office Phil Graham 07941 508026 [email protected] PROJECT Bromley Little Theatre A3 posters DESCRIPTION Posters to advertise a variety of different plays being performed at the theatre. Website graphics AN AMATEUR PRODUCTION BY ARRANGEMENT WITH SAMUEL FRENCH LTD AN AMATEUR PRODUCTION BY ARRANGEMENT WITH NICK HERN BOOKS for each play were also created. KING CHARLES III BY MIKE BARTLETT Directed by PAULINE ARMOUR Fri 12th - Sat 20th Oct 2018 at 7.45pm (not Sun 14th) BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB Members: £8 / Non-members: £12 • Booking opens to non-members on 10th October BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 Tickets also available from the Churchill Theatre box office Members: £8 / Non-members: £12 • Booking opens to non-members on 12th Sept Members: £8 / Non-members: £12 • Booking opens to non-members on 7th Nov Phil Graham 07941 508026 [email protected] PROJECT Prostate Cancer UK Spring DM Campaign Oversized Outer (324 x 116mm) DESCRIPTION The campaign focused on catching prostate cancer early. A bold, oversized outer was used to catch the eye and entice people to find out more inside. This campaign was Prostate Cancer UK’s most successful DM pack to date. It had a response rate of 14.38% and income of £306,011 (vs 9.25% and If undelivered, please return to: Prostate Cancer UK, York House, Wetherby Road, Long Marston, York YO26 7NH £193,827 projected). Prostate Cancer UK is a registered charity in England and Wales (1005541) and in Scotland (SC039332). Registered company 02653887. 4725 13DMAA18 Mr A Sample House name1 ANY street Any town Any shire A12 B34 Help us catch prostate cancer before <APPEAL CODE/PACKAGE CODE> it grows too BIG. Small cancers are easier to treat successfully. Phil Graham 07941 508026 [email protected] PROJECT Prostate Cancer UK Spring DM Campaign (inside) 2002: STOPPING Dr Macaulay and her team start investigating the role Z Fold / Roll Fold of IGFs in prostate cancer cells. They find that there’s PROSTATE CANCER more IGF receptor (IGFR) in clinical prostate cancer Leaflet samples compared to non-cancerous areas of the FROM GROWING: prostate – and that this is maintained in cancer that’s spread outside the prostate. This raises the possibility How your donations opened a that IGFs are involved in prostate cancer growth. window for new treatment of 2004 - 2006: DESCRIPTION Dr Macaulay gets her first grants from Prostate early prostate cancer Cancer UK. Her team finds that reducing levels Dr Valentine Macaulay is a Medical Oncologist and of IGFR in prostate cancer cells makes them Clinician Scientist at the University of Oxford. more sensitive to radiotherapy, which works by Following the damaging the cancer cells’ DNA. They also find that 2011 - 2015: She’s interested in the role of insulin like growth Other research in Dr Macaulay’s lab showed that factors – or IGFs – in how cancers grow and spread. levels of IGFR increase as prostate cancer grows ‘Size Matters’ theme, and spreads. This suggests that targeting IGF/ IGFR isn’t just found on the cell surface, but can IGFs are hormone-like proteins that help cells grow. IGFR could lead to a potential new treatment for also be found in the nucleus – the cell’s control a leaflet inside This is essential during normal development. They’re advanced disease. centre. Further funding from Prostate Cancer UK part of what tells the cells in our growing bodies how allows Dr Macaulay’s team to take this insight one explained more about to change from a cluster of cells into an embryo, from 2009 - 2012: step further. They discover that IGFR is more likely an embryo to a baby and from a baby to an adult. A Prostate Cancer UK funded student in to be in the nucleus of cancer cells, but stays on But when cancer cells hijack this normally tightly Dr Macaulay’s lab continues this work by finding the surface of normal cells. They also find that the research and also controlled programme, they grow uncontrollably. out that blocking IGFR also increases DNA damage when prostate cancer cells are exposed to high in untreated cancer cells. The increase in damage levels of IGF, it drives the receptor from the cell featured a case study. Over the last 16 years, and thanks in large part to isn’t quite enough to kill cancer cells on its own, surface to the nucleus. Once there, it binds the your donations, Dr Macaulay’s research has taken but this observation opens the door to further DNA and switches on genes responsible I really do hope that her on a fascinating journey of discovery from an research into combination treatments that might tip for cancer growth and movement. This tells initial observation to a promising new treatment for the balance from simply damaging cancer cells to Dr Macaulay what processes any new treatment The front of the leaflet my research will make prostate cancer. killing them completely. would have to combat to be successful. said ‘Think Big’ and, a difference. when opened out, Dr Valentine Macaulay, University of Oxford. reads ‘Think Bigger’. Prostate Cancer UK funded researcher. 2002: 2004: 2009: Dr Macaulay starts investigating IGFs in Dr Macaulay gets her first grant from Prostate Dr Macaulay recruits a Prostate Cancer prostate cancer. There’s more IGFR in prostate Cancer UK and discovers IGFR levels increase UK funded PhD student. Blocking IGFR cancer than normal prostate samples. as prostate cancer grows and spreads. destabilises untreated prostate cancer cells. 2017: She plans to conduct a ‘window trial’ in men with recommendation to be kept on active surveillance My diagnosis made me acutely All this previous laboratory work leads localised prostate cancer who have chosen to with regular monitoring. I suppose you always start We need your help Dr Macaulay to ask the critical question: Can have a radical prostatectomy. Dr Macaulay intends out aiming for the treatment that will have the fewest aware of the dangers posed by blocking IGF in the blood stop prostate cancer to treat the men on this trial with an IGF blocking side effects. not knowing your family history of to invest in better growing in men with localised disease? drug in the four-week window between electing to have surgery and actually having the operation. “While I was on active surveillance, I had regular prostate cancer, and of the critical diagnosis to find This is the question that, thanks to people like you, She’ll then compare the expression of several check-ups; probably three biopsies over the five she hopes to answer within a new Prostate Cancer importance of early diagnosis. genes associated with cancer growth and spread years. After one of them, I asked the urologist UK Research Innovation Award. prostate cancer between the man’s initial diagnostic biopsy and a about playing golf the next day – I had a game lined after three, or even four years if I saw myself ever tissue sample from after his prostatectomy. In the up that I didn’t want to miss. He said ‘no way’, but needing an operation, I’d have said ‘no’. And in early and save more long term, she hopes to show that blocking IGF in I actually managed fine. Once again, I think that the end, it’s only the calm voice of the professional men on active surveillance for small cancers can being fit helped. stating that you need to take action now that men like David. reduce the likelihood of their cancer growing and makes you realise you do really need treatment. needing treatment. “I suppose it is a weird feeling to know that you have a tumour inside you, but I had absolute confidence This is just one of many research projects that, “I looked at the Prostate Cancer UK website to help DONATE NOW. in my urologist – I got to know him very well over with further funding, could make their way from me sort through the treatment options and possible laboratory observation to real clinical benefits. those five years. We even play golf together now. I side effects, and I know I fared better than many felt like I knew the status of my tumour at all times, men in that respect. But I’d still say that anything But for new ways to treat men with early prostate and I knew that he’d pick up on any changes.
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