<<

PROJECT Little Theatre A3 posters

DESCRIPTION Posters to advertise a variety of different plays being performed at the theatre.

IN THE AN AMATEUR PRODUCTION BY ARRANGEMENT WITH SAMUEL FRENCH LTD BAR AN AMATEUR PRODUCTION BY ARRANGEMENT WITH SAMUEL FRENCH LTD Website graphics CONTAINS VERY STRONG LANGUAGE AND SEXUAL REFERENCES THROUGHOUT for each play were also created.

AN AMATEUR PRODUCTION BY ARRANGEMENT WITH SAMUEL FRENCH LTD

BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB BROMLEY LITTLE THEATRE, IN THE BAR, NORTH STREET, BROMLEY KENT BR1 1SB BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 Members: £8 / Non-members: £12 • Booking opens to non-members on 8th November Members: £8 / Non-members: £12 • Booking opens to non-members on 13th Sept Members: £7 / Members’ guests: £10 • Booking opens on 22 August Tickets also available from the box office

Phil Graham 07941 508026 [email protected] PROJECT Bromley Little Theatre A3 posters

DESCRIPTION Posters to advertise a variety of different plays being performed at the theatre. Website graphics AN AMATEUR PRODUCTION BY ARRANGEMENT WITH SAMUEL FRENCH LTD AN AMATEUR PRODUCTION BY ARRANGEMENT WITH NICK HERN BOOKS for each play were also created.

KING CHARLES III BY MIKE BARTLETT

Directed by PAULINE ARMOUR Fri 12th - Sat 20th Oct 2018 at 7.45pm (not Sun 14th)

BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB BROMLEY LITTLE THEATRE, NORTH STREET, BROMLEY KENT BR1 1SB Members: £8 / Non-members: £12 • Booking opens to non-members on 10th October BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 BOOKING: visit www.bromleylittletheatre.org or call 0333 666 3366 Tickets also available from the Churchill Theatre box office Members: £8 / Non-members: £12 • Booking opens to non-members on 12th Sept Members: £8 / Non-members: £12 • Booking opens to non-members on 7th Nov

Phil Graham 07941 508026 [email protected] PROJECT Prostate Cancer UK Spring DM Campaign Oversized Outer (324 x 116mm)

DESCRIPTION The campaign focused on catching prostate cancer early. A bold, oversized outer was used to catch the eye and entice people to find out more inside. This campaign was Prostate Cancer UK’s most successful DM pack to date. It had a response rate of 14.38% and income of £306,011 (vs 9.25% and If undelivered, please return to: Prostate Cancer UK, York House, Wetherby Road, Long Marston, York YO26 7NH £193,827 projected). Prostate Cancer UK is a registered charity in England and Wales (1005541) and in Scotland (SC039332). Registered company 02653887.

4725 13DMAA18

Mr A Sample House name1 ANY street Any town Any shire A12 B34 Help us catch prostate cancer before it grows too BIG. Small cancers are easier to treat successfully. Phil Graham 07941 508026 [email protected] PROJECT Prostate Cancer UK Spring DM Campaign (inside) 2002: STOPPING Dr Macaulay and her team start investigating the role Z Fold / Roll Fold of IGFs in prostate cancer cells. They find that there’s PROSTATE CANCER more IGF receptor (IGFR) in clinical prostate cancer Leaflet samples compared to non-cancerous areas of the FROM GROWING: prostate – and that this is maintained in cancer that’s spread outside the prostate. This raises the possibility How your donations opened a that IGFs are involved in prostate cancer growth. window for new treatment of 2004 - 2006: DESCRIPTION Dr Macaulay gets her first grants from Prostate early prostate cancer Cancer UK. Her team finds that reducing levels Dr Valentine Macaulay is a Medical Oncologist and of IGFR in prostate cancer cells makes them Clinician Scientist at the University of Oxford. more sensitive to radiotherapy, which works by Following the damaging the cancer cells’ DNA. They also find that 2011 - 2015: She’s interested in the role of insulin like growth Other research in Dr Macaulay’s lab showed that factors – or IGFs – in how cancers grow and spread. levels of IGFR increase as prostate cancer grows ‘Size Matters’ theme, and spreads. This suggests that targeting IGF/ IGFR isn’t just found on the cell surface, but can IGFs are hormone-like proteins that help cells grow. IGFR could lead to a potential new treatment for also be found in the nucleus – the cell’s control a leaflet inside This is essential during normal development. They’re advanced disease. centre. Further funding from Prostate Cancer UK part of what tells the cells in our growing bodies how allows Dr Macaulay’s team to take this insight one explained more about to change from a cluster of cells into an embryo, from 2009 - 2012: step further. They discover that IGFR is more likely an embryo to a baby and from a baby to an adult. A Prostate Cancer UK funded student in to be in the nucleus of cancer cells, but stays on But when cancer cells hijack this normally tightly Dr Macaulay’s lab continues this work by finding the surface of normal cells. They also find that the research and also controlled programme, they grow uncontrollably. out that blocking IGFR also increases DNA damage when prostate cancer cells are exposed to high in untreated cancer cells. The increase in damage levels of IGF, it drives the receptor from the cell featured a case study. Over the last 16 years, and thanks in large part to isn’t quite enough to kill cancer cells on its own, surface to the nucleus. Once there, it binds the your donations, Dr Macaulay’s research has taken but this observation opens the door to further DNA and switches on genes responsible I really do hope that her on a fascinating journey of discovery from an research into combination treatments that might tip for cancer growth and movement. This tells initial observation to a promising new treatment for the balance from simply damaging cancer cells to Dr Macaulay what processes any new treatment The front of the leaflet my research will make prostate cancer. killing them completely. would have to combat to be successful. said ‘Think Big’ and, a difference. when opened out, Dr Valentine Macaulay, University of Oxford. reads ‘Think Bigger’. Prostate Cancer UK funded researcher. 2002: 2004: 2009: Dr Macaulay starts investigating IGFs in Dr Macaulay gets her first grant from Prostate Dr Macaulay recruits a Prostate Cancer prostate cancer. There’s more IGFR in prostate Cancer UK and discovers IGFR levels increase UK funded PhD student. Blocking IGFR cancer than normal prostate samples. as prostate cancer grows and spreads. destabilises untreated prostate cancer cells.

2017: She plans to conduct a ‘window trial’ in men with recommendation to be kept on active surveillance My diagnosis made me acutely All this previous laboratory work leads localised prostate cancer who have chosen to with regular monitoring. I suppose you always start We need your help Dr Macaulay to ask the critical question: Can have a radical prostatectomy. Dr Macaulay intends out aiming for the treatment that will have the fewest aware of the dangers posed by blocking IGF in the blood stop prostate cancer to treat the men on this trial with an IGF blocking side effects. not knowing your family history of to invest in better growing in men with localised disease? drug in the four-week window between electing to have surgery and actually having the operation. “While I was on active surveillance, I had regular prostate cancer, and of the critical diagnosis to find This is the question that, thanks to people like you, She’ll then compare the expression of several check-ups; probably three biopsies over the five she hopes to answer within a new Prostate Cancer importance of early diagnosis. genes associated with cancer growth and spread years. After one of them, I asked the urologist UK Research Innovation Award. prostate cancer between the man’s initial diagnostic biopsy and a about playing golf the next day – I had a game lined after three, or even four years if I saw myself ever tissue sample from after his prostatectomy. In the up that I didn’t want to miss. He said ‘no way’, but needing an operation, I’d have said ‘no’. And in early and save more long term, she hopes to show that blocking IGF in I actually managed fine. Once again, I think that the end, it’s only the calm voice of the professional men on active surveillance for small cancers can being fit helped. stating that you need to take action now that men like David. reduce the likelihood of their cancer growing and makes you realise you do really need treatment. needing treatment. “I suppose it is a weird feeling to know that you have a tumour inside you, but I had absolute confidence This is just one of many research projects that, “I looked at the Prostate Cancer UK website to help DONATE NOW. in my urologist – I got to know him very well over with further funding, could make their way from me sort through the treatment options and possible laboratory observation to real clinical benefits. those five years. We even play golf together now. I side effects, and I know I fared better than many felt like I knew the status of my tumour at all times, men in that respect. But I’d still say that anything But for new ways to treat men with early prostate and I knew that he’d pick up on any changes. that can keep men on active surveillance for longer, cancer, like this one, to reach their true potential, like the new drug Dr Macaulay hopes to test, would “Unfortunately that’s what happened in December we have to get better at diagnosing prostate be a huge benefit. I’d like to say a personal thank cancers early on, when they’re still confined within DAVID’S STORY 2016. My PSA moved slightly and an MRI scan you to everyone whose donations have made it the prostate. “I didn’t know that I was at higher risk of being confirmed that the cancer was growing. The possible for her to take her research as far as a diagnosed with prostate cancer because my urologist told me it was time to intervene. At that clinical trial. Will you help us bring brother had it. Luckily, I happened to mention his point, I didn’t want to have treatment. I have a very improvements in prostate cancer diagnosis at my next routine medical, and luckily busy job, and an active lifestyle. I knew I could “My diagnosis made me acutely aware of the again, the doctor picked up on this and I had a end up with incontinence or erectile dysfunction. dangers posed by not knowing your family history diagnosis out of the lab and into test. I was referred to a urologist and diagnosed. Incontinence in particular... I mean that’s about as of prostate cancer, and of the critical importance of the clinic? bad as it can get for a man. Although my medical early diagnosis. “I saw a number of different doctors to decide what team were very good at preparing me for the side treatment to go for, including a urologist, a surgeon effects, I had no idea how long I’d be out of action. “I believe it’s time to take the luck out of early and and an oncologist. I’m a very keen golfer, so I was accurate prostate cancer diagnosis. That’s why fairly fit and, apart from the prostate cancer, healthy. “At the point that the urologist told me that the I’m glad that Prostate Cancer UK are investing so I was advised that at that stage, my cancer was cancer had started growing, I actually asked, ‘Is heavily in this area. And that they’re as committed 2011: 2017: low risk. I like to think that I’m fairly savvy, and I this really necessary?’. It’s funny because the as I am to implementing a reliable prostate cancer Dr Macaulay receives further Prostate Cancer UK Dr Macaulay gets funding for the first clinical trial. had the advantage of having spoken to my brother longer you’re on active surveillance, the less likely it screening programme in the UK – one that’s based funding and discovers high levels of IGF drive IGFR Can blocking IGF in the blood prevent prostate about his treatment too. My wife and I listened to feels that things are ever going to change and you’ll on more than just a PSA test. Prostate cancer is a Prostate Cancer UK is a registered charity in England and Wales (1005541) Phil Graham into the nucleus of lab-grown prostate cancer cells. cancer growth in men with early disease? all the advice, and were very confident in the overall ever actually need treatment. If you’d asked me killer. But it doesn’t need to be.” and in Scotland (SC039332). Registered company 02653887. 4725 07941 508026 [email protected]

229mm high

[email protected]

13DMAE18

Word NOW on one page lea et to appear in smaller window window smaller smaller in in appear appear to to et et lea lea page page one one on on NOW NOW Word Word 5064

Insert

07941 508026 07941

Registered company 02653887. company Registered

Prostate Cancer UK is a registered charity in England and Wales (1005541) and in Scotland (SC039332). (SC039332). Scotland in and (1005541) Wales and England in charity registered a is UK Cancer Prostate

Phil Graham Phil

If undelivered, please return to: Prostate Cancer UK, York House, Wetherby Road, Long Marston, York YO26 7NH 7NH YO26 York Marston, Long Road, Wetherby House, York UK, Cancer Prostate to: return please undelivered, If Address on folded letter to appear in large window window large large in in appear appear to to letter letter folded folded on on Address Address

The News, 2023 2023 News, The The News, 2023 2023 News, The Please send this back to us with your donation form. form. donation your with us to back this send Please

P P P LAP MAIN O GLUEING OR WHIE P PAR HIS P KEEP

KEEP FLAPWHITEFORGLUEING

with this. this. with

level of engagement engagement of level

and there was a high high a was there and

Help REWRITE donation their with it

the insert and return return and insert the

time, what headline would you like to read? to like you would headline what time, In five years five

the headlines of back the in fill to

KEEP FLAP WHITE FOR GLUEING WHITE FLAP KEEP

FUTURE HEADLINE FUTURE own your Write

Supporters were asked asked were Supporters

from five years time. years five from

possible future headline headline future possible

The Independent, February 2018 a featured insert This

insert could be seen. seen. be could insert Outer

through which an an which through

It had a window window a had It

biggest cancer killer. killer. cancer biggest

he ndeendent ebruary 2018 ebruary ebruary ndeendent Independent, he he

cancer as the third third the as cancer

overtaking breast breast overtaking

cancer being a killer. a being cancer prostate cancer cancer prostate

and stop prostate prostate stop and real headline about about headline real

P KEEPLAPWHIEORGLUEING The outer featured a a featured outer The the headlines the

Help us improve scans scans improve us Help

future headlines. future CODE/PACKAGE CODE/PACKAGE

HEADLINES A12 B34 A12

was about changing changing about was

A12 B34 A12

shire Any

shire Any

town Any

cancer, this theme theme this cancer,

town Any

RE-WRITE THE THE RE-WRITE street ANY

street ANY

name1 House

name1 House about prostate prostate about

Sample A Mr

Sample A Mr

and today Donate

229mm high articles news profile Following some high high some Following

P P KEEP LAP WHIE OR GLUEING

DESCRIPTION

13DMAE18

13BMAJ17

5064 4836

KEEP THIS PART WHITE FOR GLUEING OF MAIN FLAP

Registered company 02653887. company Registered C5 Outer and Insert and Outer C5

Registered company 02653887. company Registered

Prostate Cancer UK is a registered charity in England and Wales (1005541) and in Scotland (SC039332). (SC039332). Scotland in and (1005541) Wales and England in charity registered a is UK Cancer Prostate

Prostate Cancer UK is a registered charity in England and Wales (1005541) and in Scotland (SC039332). (SC039332). Scotland in and (1005541) Wales and England in charity registered a is UK Cancer Prostate

If undelivered, please return to: Prostate Cancer UK, York House, Wetherby Road, Long Marston, York YO26 7NH 7NH YO26 York Marston, Long Road, Wetherby House, York UK, Cancer Prostate to: return please undelivered, If

If undelivered, please return to: Prostate Cancer UK, York House, Wetherby Road, Long Marston, York YO26 7NH 7NH YO26 York Marston, Long Road, Wetherby House, York UK, Cancer Prostate to: return please undelivered, If

Summer DM Campaign Campaign DM Summer

Address on folded letter to appear in large window UK Cancer Prostate

fIf undelieredundelivered, leaseplease return toto: Prostate ancerCancer UK, orkYork ouseHouse, etherbyWetherby oadRoad, onLong arstonMarston, orkYork YO26 7NH Prostate ancerCancer UK is a reisteredregistered charity in nlandEngland and alesWales (1005541) and in cotlandScotland .(SC039332). PROJECT eisteredRegistered comanycompany .02653887.

Word NOW on one page lea et to appear in smaller window 5064 13DMAE18

KEEP FLAPWHITEFORGLUEING mm hih mm KEEP FLAP WHITE FOR GLUEING FOR WHITE FLAP KEEP

The Independent, February 2018

the headlines the Help REWRITE REWRITE Help

KEEP THIS PART WHITE FOR GLUEING OF MAIN FLAP

Address on folded letter to appear in large window Word NOW on one page lea et to appear in smaller window PROJECT “When I first started, nobody knew anything Prostate Cancer UK about prostate cancer – breast cancer research had all the funding and all the knowledge. ow as time’s gone on, we’ve Summer DM Campaign followed in the footsteps of breast cancer research and we’ve learnt from their It means my sons (inside) successes and their mistakes. So we’ve won’t have to face progressed prostate cancer research much, much faster by being able to learn from prostate cancer Roll Fold Leaflet what they’ve done. as I am. “The reason I do what I do is because I want to have an impact on patients. I meet with a prostate cancer support group, and if anything happens to one of them it DESCRIPTION For a screening programme we need a cheap, reliable test that could really means something. That’s easy to forget if you’re at the follow the PSA test to rule out some false positives before having lab bench all the time. an mpMRI scan. This will most likely be an advanced type of blood Following the test that looks for several markers of cancer, including proteins and ‘Changing future high-risk genes. We’re funding Dr Hayley Whitaker to study a range of markers to see headlines’ theme, the how well they predict the results from an mpMRI scan. By combining the best markers, she hopes to be able to reduce the number of men I have Kevin’s letter to me framed on the wall in leaflet explained how needing scans. the lab and I’ve said to the team that on those days Prostate Cancer UK Not only that, but the project is also trying to see if they can improve the when your experiments aren’t working, we’ll read quality of the mpMRI scans. Currently about 40 per cent of scans do not aim to do it through a give a definitive result and she is proposing to test a more advanced type that and remember why we need to carry on until of scan called VERDICT, which could help to give a clearer picture. screening programme, we get it right. Dr Hayley Whitaker A SCREENING as well as featuring a case study, reminding why it is so important. OUR RESEARCH PROGRAMME Front When closed, the front of the leaflet says ‘A 06 4 screening programme’ 5 Prostate Cancer UK is a registered charity in England and Wales (1005541) and in Scotland (SC039332). Registered company number 02653887. and, as the bottom is cut off, then reads ‘...can stop prostate Early diagnosis is crucial to save lives to catch the cancer before it spreads Prostate cancer has become the third biggest cancer killer in the UK − outside the prostate. However, symptoms don’t always appear at the early for the first time ever, the latest data showed that the number of deaths cancer being a killer’. stages, not enough people know if they’re at higher risk and current tests are has exceeded those caused by breast cancer. not accurate enough to test every man. When opened up, the What we need are new tests and improvements at each stage of diagnosis second page then reads to avoid unnecessary biopsies and treatments, without missing the dangerous, aggressive cancers. Realistically this will need a series of tests, ‘Our research can stop as shown below, that can help to filter out the men who won’t need a biopsy. BBC News, February 2018 prostate cancer being 1000

Breast cancer a killer’. Then, when 12000 Improved PSA test PSA test fully opened, the centre page says ‘YOU can 10000 stop prostate cancer Biomarker blood test Biomarker blood1 test 2007 201 The shock of this news has massively raised awareness of the ticking being a killer’. time bomb that prostate cancer represents. The number of families that will be torn apart will continue to rise if we don’t do anything about it. mpMRI scan mpMRIWe scan are committed to taming prostate cancer and we will be intensifying our efforts to reverse this trend but we need funds to continue this work. The research we have funded over the years, thanks to your support, is now starting to pay off and a screening programme could be within reach in just a few years. Biopsy Biopsy

Key: No prostate cancer detected Aggressive Aggressive prostate cancer Man with prostate cancer diagnosed early prostate cancer diagnosedY early OU Phil Graham can stop prostate 07941 508026 [email protected] cancer being a killer. PROJECT Prostate Cancer UK Autumn DM Campaign INVEST TODAY FOR A BETTER FUTURE It takes on average 17 years for a new For instance, the biggest leap forward 170 x 297mm Leaflet research discovery to go from the lab in prostate cancer diagnosis in the and into everyday use by doctors. past generation came about from our This means we always have to be supporters. Supporting vital research looking ahead to see what are the big helps to get research through to the next INVEST TODAY FOR breakthroughs that are coming through. stage and into everyday use. DESCRIPTION A BETTER FUTURE There are lots of hurdles that new research needs to overcome, including How your gift can yield returns for all men finding funding, before it can progress The campaign focused through each stage of testing, validation, evaluation. Sometimes this can mean It’s difficult to get research on the theme of that good research sits idle because the funding when you want to try support isn’t there to keep it progressing. something radically different... ‘Investing in the future’ It doesn’t always take a huge amount of charity funding allows us to test money to do that, and in fact our smaller a potentially ground-breaking and the leaflet was research grants can help to leverage new idea. more funding from other sources, like Professor Mark Emberton, designed to look like a the government. This is how just even a Lead researcher small investment can yield huge returns. financial booklet with charts and graphs, as Spending on prostate cancer by government and charities in UK well as using banking £30m £26.46m £25m style language. £20m

£15m The campaign received £10m the highest single £5m donation for a DM pack £0m to date. 2002/03 2003/04 2004/05 2005/06 2006/07 2007/08 2008/09 2009/10 2010/11 2011/12 2012/13 2013/14 2014/15 2015/16 2016/17

INVESTINVEST TODAY TODAY FOR FOR A A BETTER BETTER FUTURE FUTURE INVESTINVEST TODAY TODAY FOR FOR A A BETTER BETTER FUTURE FUTURE

mpMRI scans, to set standards on the SAVING LIVES EARNING INTEREST MAKING RETURNS best way to carry out the scans for men, YIELDING DIVIDENDS For over 30 years, the most common Over the next couple of years, we Thanks to the early research showing developed a set of protocols for the It’s clear that research investment can way to diagnose prostate cancer and Most men were very awarded three grants totalling £136,000 that the trial could work, funders could be machines to get the best quality scan take some time to pay off. But when it determine whether or not it needs uncomfortable with the existing to Professor Emberton and Hash Ahmed more confident in the success of the trial. and worked to address the shortages does, it can make a huge difference. We treating, has been based on the results diagnostic strategy and were at University College Hospital Our investment allowed a brilliant idea in radiologists. often have to play the long game with of a TRUS biopsy. This involves using aware of the imprecision to test the feasibility of using mpMRI to to get off the ground, drawing in greater research, looking for those bright flashes a series of needles that sample tissue in diagnosis. detect prostate cancer. funding from the government and a much We have just repeated our Freedom of of inspiration that need a bit of support across the prostate, to see if it contains better quality of diagnosis for men. Information requests, which show that to get them off the ground. Professor Mark Emberton, any cancerous cells. Those studies provided data and there has been a marked increase in the Lead researcher evidence that allowed them to secure mpMRI is now being rolled out availability of these scans, with half of For instance, we’re always looking ahead feeling for a lump! It’s still early days, just The problem is that because there are over £2 million in government funding to These are much more thorough than a nationwide and Prostate Cancer UK areas offering the gold standard scans to to the next big advance. Some of our as mpMRI was not that long ago, but gaps between the needles, sometimes carry out the PROMIS trial. standard biopsy, allowing the researchers have been working with policymakers to men. This still isn’t good enough, but we recent research has found that a special we know there is always the potential for significant cancers can be missed if that to find small cancers that might have ensure that every man has access to a are pleased with the rate of progress and type of ultrasound called Shear Wave huge returns for men. section of tissue isn’t sampled. The other lives saved by early detection of cancer. “It’s difficult to get research funding been missed otherwise. However this high-quality scan. there are plans in place to ensure that Elastography could be just as accurate problem is that although biopsies are a mpMRI will help to shift that balance when you want to try something radically means they are much more painful and all eligible men have access in their local as mpMRI while being cheaper and Those paths to impact might, in some key part of diagnosis, they are invasive and, in combination with improvements different. Large research funders are very men in the trial needed to be given a In 2016, we made Freedom of area within the next couple of years. easier to use. cases, take years to achieve. But as and painful, and can sometimes lead to in other areas, will put us closer than conservative in their decisions. Charity general anaesthetic. Information requests to all areas of the the PROMIS trial shows us, the long serious infections – so we only want men ever before to having a nationwide funding allowed us to test out a new country to find out how widely available This goes to show that it isn’t just about This clever technique is able to scan the game can and will pay off. In the coming to have them if they need them. screening programme. idea; there was nowhere else to go. So “The altruism exhibited by men was the scans were. We showed that only investing in the research, but as a body and measure the stiffness of the years, we expect the research we’re when we applied for funding for the full humbling and extraordinary. Most a third of men had access to a scan in charity we are uniquely placed to make tissue in the prostate, which also seems funding today to transform the diagnosis, Our work into mpMRI, a more Allowing men to avoid unnecessary trial it helped to have done these smaller men were very uncomfortable with the their local area. We’ve worked since sure that new research findings are put to suggest how aggressive the cancer treatment and prevention of prostate sophisticated form of MRI, led to biopsies came from a trial, known studies as we already had very promising existing diagnostic strategy and were then to help get the training needed into practice and make a difference for is. Think of it as a virtual doctor’s finger cancer in exactly the same way. research that showed it can improve as PROMIS, which made a hugely results,” says Professor Emberton. aware of the imprecision in diagnosis for radiologists to interpret and report men everywhere. detection of aggressive cancers while ambitious effort to show the benefit but most men were willing to undergo a reducing the number of unnecessary of mpMRI. But this may not have One of the difficult issues for the trial was degree of risk to help us get there,” says biopsies for men by a quarter. happened, if it weren’t for our efforts to the need for template mapping biopsies. Professor Emberton. 2018 2016 2017 bring together researchers from different New research shows 2010 We work with a range This has been a significant step towards areas at our annual research forum. 2009 Results from PROMIS that mpMRI can 2008 of stakeholders to our ambition for a prostate cancer Proportion of areas in UK offering mpMRI scans The Department of show the benefit of be used to guide We award a series address the barriers before biopsy to high standards Our research Health award using mpMRI biopsies more screening programme. Overcoming the “The idea for PROMIS came from a of grants to build and challenges to conference brings £2 million in funding for before biopsy. accurately, reducing harm done by unnecessary biopsies is forum held by the charity around 2008. evidence for adoption of mpMRI researchers together PROMIS trial. the chances of missing using mpMRI. We release the before biopsy and use one of the biggest hurdles to achieving That’s where PROMIS was born. If and leads to idea for aggressive cancers. these to support the this. If all men were screened for we hadn’t had that meeting, PROMIS PROMIS trial. results of Freedom of Information requests NHS to adopt it. We update the prostate cancer, then the harm from may not have happened,” says lead 33% 57% showing that most men Freedom of Information all those biopsies could outweigh the researcher Professor Mark Emberton. do not have access data which shows that to mpMRI scans half of men now have Phil Graham 2016 2018 before biopsy. access to scans. 07941 508026

[email protected] INVEST TODAY FOR A BETTER FUTURE INVESTINVEST TODAY TODAY FOR FOR A A BETTER BETTER FUTURE FUTURE INVEST TODAY FOR A BETTER FUTURE INVESTINVEST TODAY TODAY FOR FOR A A BETTER BETTER FUTURE FUTURE PROJECT Prostate Cancer UK Christmas DM Campaign Oversized Outer The GREATEST GIFT (324 x 116mm) Peel here DESCRIPTION A large outer featured a branded cracker, with peel-off area down the centre. When peeled off, the cracker was ‘broken open’ and the back of the leaflet, which featured an enticing quote, could be seen through the window. ever found in a cracker...

5250 If undelivered, please return to: Prostate Cancer UK, York House, Wetherby Road, Long Marston, York YO26 7NH

Prostate Cancer UK is a registered charity in England and Wales (1005541) and in Scotland (SC039332). Registered company 02653887.

Mr A Sample House name1 ANY street Any town Any shire A12 B34 ...and crack this open BARCODE to find your FREE Christmas decoration.

Phil Graham 07941 508026 [email protected] Breast cancer European Age- Standardised A biobank of samples Mortality rates PSA first used for diagnosis. from PREDICT are saved in the UK. Although concerns are so that in future newer known about its accuracy, ways to diagnose prostate cancer can be tested it’s the best test available. We start funding research into Pilot phase of trial 1988 against current tools. using mpMRI to avoid unnecessary completes to show that 1971 biopsies, providing evidence recruitment is on track and 1988 the process is feasible. 2016 leading to the PROMIS trial. 1995 PROJECTPROMIS We start to establish trial to combine new results show tests, including mpMRI, to prove whether 2024 that mpMRI Breast cancer Prostate Cancer UK they are good enough to have a screening can reduce programme for prostate cancer in the NHS. Onwards screening 2010 unnecessary begins in the Early Christmas biopsies. 2019 UK, saving We start to establish trial to combine new PROMIS Our first grant into DM Campaign (inside) thousands 1990s tests, including mpMRI, to prove whether genetics research helps My prostate cancer The PREDICT trial aimsresults to test show the effectiveness of a screening of lives. 2008 they are good enough to have a screening Recruitment to trial finishes and understand each man’s Leaflet - Gatefold The improvements that we’re making in diagnosis combine lots of programme by recruitingthat 20,000 mpMRI men from around the UK over five Tony was diagnosed with prostate cancer 2020 was only diagnosed programme for prostate cancer inyears. the NHS.Each of the mencan taking reduce part in the trial would be given tests that results are analysed to see the risk of prostate cancer. Our with extended flaps different aspects of our past research: testing for proteins in the blood, last year at the age of 60. He’s a keen runner accuracy of these tests. If the results We start funding research into combine information unnecessaryon a man’s risk of prostatePilot cancer phaseMy as of wellprostate trial as blood cancer continued research discovers One of our previous identifying genetic changes that increase the risk of getting prostate and after visiting the doctor for a persistent are as hoped, we call for a screening reverse folded Tony was diagnosed with prostateusing cancer mpMRI to avoid unnecessary biomarkers to give a potentiallybiopsies. more accuratecompletes result. to show that Tonyhundreds was diagnosed of genes with involved. prostate cancer PhD students,The HayleyPREDICT trial aims to test the effectiveness of a screeningwhen cancer, and confirming by an mpMRI scan. groinThe improvements pain he was thattold we’rethat he making had incurablein diagnosis combine lots of Trial begins recruitment. programme for prostateThe improvements cancer. that we’re making in diagnosis combine lots of it waslast too year at late. the age of 60. He’s a biopsies,keen runner providing evidence recruitmentwas is ononly track and diagnosed last year at the age of 60. He’s a keen runner Whitaker, developsprogramme a test by recruiting 20,000 men from around the UK over five Pull here prostatedifferent aspects cancer. of our past research: testing for proteins in the blood, GP surgeries sign up different aspects of our past research: testing for proteins in the blood, The PREDICT trial aims to test the effectiveness of a screening 2017 PSA first used for diagnosis.As you’ll see in the timeline overleaf,leading it has to taken the PROMISmany years trial. for each of If a man gets a positive score on any of these thetests, process or the standardis feasible. 2018 and after visiting the doctor for a persistent for a bloodyears. biomarker Each of the men taking part in the trial would be givenA screeningtests that and programme after visiting the doctor for a persistent it was tooidentifying late. genetic changes that increase the risk of getting prostate to take part and send identifying genetic changes that increase the risk of getting prostate programme by recruiting 20,000 men from around the UK over five Although concerns arethese areas of research to reach this point where they can be combined 2019PSA test, then he’ll be sent for an advanced type ofwhen MRI scan known as groin pain he was told that he had incurable that could becombine used forinformation onDESCRIPTION a man’s risk of prostate cancer as well as blood groin pain he was told that he had incurable “Thecancer, thought and confirming of not seeing by an my mpMRI 5-year-A scan. biobank of samples out invitations to men cancer, and confirming by an mpMRI scan. years. Each of the men taking part in the trial would be given tests that known about its accuracy,successfully in this way. 2010 mpMRI and, if needed, a biopsy. By the end of the trial, we hope to be from PREDICT are saved prostate cancer. prostate cancerbiomarkers diagnosis. to give a potentially more accurate result. prostate cancer. old grandson grow to be a teenager was eligible for the trial. combine information on a man’s risk of prostate cancer as well as blood Breast cancer couldit’s the best SAVE test available. many able to see how many aggressive cancers are detected by each of the As you’ll see in the timeline overleaf, it has taken many years for each of I really hope that A screening Pull here programmeabsolutely devastating – he’s the appleso that of in future newer As you’ll see in the timeline overleaf, it has taken many years for each of biomarkers to give a potentially more accurate result. Continuing with the Professor Hash Ahmed from Imperial College London will be leading “The thought of not seeing my 5-year- IfEuropean a man gets Age- a positive score on any of these tests, or the standard “The thought of not seeing my 5-year-2018 tests and how many men they sent2017 for further tests unnecessarily. mythese eye,” areas Tony of research says. “Prostate to reachways thiscancer point to hasdiagnose where they prostate can be combined I really hope that these areas of research to reach this point where they can be combined old grandson grow to be a teenager was Standardised cracker theme, the thousands ofoldthe grandsontrial.lives. He co-led grow theto be ground-breaking a teenager was PROMIS trial that built on 2024 successfully in this way. Pull here PSA test, then he’ll be sentwithin for an advanced a typefew of MRI years’ scan known as I really hopecould that SAVE manyhad a devastating impact on our family,cancer we can be tested successfully in this way. our earlier research and led to widespread use of mpMRI scans We need to see how well these If a man gets a positive score on any of these tests, or the standard absolutely devastating – he’s the apple of mpMRIMortality and, rates if needed, a biopsy. By the end of the trial, we hope to be1995 absolutely devastating – he’s the apple of lead a completely different life.” against current tools. in the UK. leaflet is opened by Tony Collier around the country. tests work across a wide population Professor Hash Ahmed from Imperial College London will be leading within a few years’ PSA test, then he’ll be sent for an advanced type of MRI scan known as my eye,” Tony says. “Prostate cancer has able to see how many aggressivetime, cancers by are the detected time by each my of the my eye,” Tony says. “Prostate cancer has One of our previous within a few years’ Professor Hash Ahmed from Imperial College London will be leading in combination with mpMRI scans thousands of lives.the trial. He co-led the ground-breaking PROMIS trial that built on mpMRI and, if needed, a biopsy. By the end of the trial, we hope to be had a devastating impact on our family, we tests and how many menbeing they sent pulled for further from tests the unnecessarily. had a devastating impact on our family, we PhD students, HayleyTrial begins recruitment. Tony has semi-retired so that he can spend the trial. He co-led the ground-breaking PROMIS trial that built on Pull here 2016 time, by the time my able to see how many aggressive cancers are detected by each of the “In the UK, we are leading the world in and within the structure of the NHS 2020 our earlier research and led to widespread use of mpMRI scans lead a completely different life.” 1988son is in his 40s, that lead a completely different2008 life.” GP surgeries sign up time, by the time my more time with his family. But this time Pull here our earlier research and led to widespread use of mpMRI scans 1988 1971 sides. The cracker having a national implementation of mpMRI Whitaker, develops a test KeepingTony families Collier tests and how many men they sent for further tests unnecessarily. We need to see how well these beforeto take we can part have and a send national ofaround year theis particularly country. hard, “Christmas around the country. and targeted biopsy. As a result of all the for a blood biomarker son is in his 40s, that Tony has semi-retired so that he can spend tests work across a widein population wethe centre have of athe screening Tony has semi-retired so that he can spend screeningout invitations programme. to men son is in his 40s, that has been really challenging since being We need to see how well these Our firstwork grant the into UK has done in diagnosis, we have that could be used for “In the UK, we are leading the world in more time with his family. But this time in combination with mpMRI scans more time with his family. But this time eligible for the trial. Recruitmentdiagnosed to trial withfinishes prostate and cancer, because “In the UK, we are leading the world in image ‘breaks’ as the Pull here tests work across a wide population Early geneticsa onceresearch in a lifetimehelps opportunity to give men prostate cancer diagnosis. together at Christmas having a national implementation of mpMRI we have a screening of year is particularly hard, “Christmas and within the structure of theprogramme NHS in place. of year is particularly hard, “Christmas we have a screening results areI’m analysed wondering to howsee themany more am I going having a national implementation of mpMRI in combination with mpMRI scans leaflet extends. understandmore each time withman’s their families,” he says. and targetedWhich biopsy. traditional As a result Christmas of all the food has been really challenging since being before we can have a national has been really challenging since being accuracyto of see?” these he tests. says. If the results and targeted biopsy. As a result of all the 1990s risk of prostate cancer. Our work the isUK the has same done size in diagnosis, as a prostate? we have Onwards programme in place. and within the structure of the NHS diagnosed with prostate cancer, because screeningBreast programme. cancer Tony Collier diagnosed with prostate cancer, because programme in place. are as hoped, we call for a screening Keeping families work the UK has done in diagnosis, we have Tony and family continued research discovers a once in a lifetime opportunity to give men before we can have a national I’m wondering how many more am I going screening The leaflet is secured I’m wondering how many more am I going programme for prostateA. Cranberry cancer. Tony and family a once in a lifetime opportunity to give men hundreds of genes involved. more time with their families,” he says. Tony Collier screening programme. to see?” he says. begins in the with small glue dots to see?” he says. Tony and family Tony Collier B. Walnut together at Christmas more time with their families,” he says. Keeping families UK, saving C. Clementine

thousands that provide a small Answer: Walnut Answer: together at Christmas of lives. amount of resistance Leaflet and even make a small Insert crack sound when it’s pulled open. It features a case The PREDICT trial aims to test the effectiveness of a screening Tony was diagnosed with prostate cancer The improvements that we’re making in diagnosis combine lots of programme by recruiting 20,000 men from around the UK over five last year at the age of 60. He’s a keen runner different aspects of our past research: testing for proteins in the blood, study, and on the years. Each of the men taking part in the trial would be given tests that and after visiting the doctor for a persistent identifying genetic changes that increase the risk of getting prostate combine information on a man’s risk of prostate cancer as well as blood groin pain he was told that he had incurable cancer, and confirming by an mpMRI scan. biomarkers to give a potentially more accurate result. prostate cancer. back, a timeline of As you’ll see in the timeline overleaf, it has taken many years for each of If a man gets a positive score on any of these tests, or the standard “The thought of not seeing my 5-year- these areas of research to reach this point where they can be combined old grandson grow to be a teenager was successfully in this way. Pull here PSA test, then he’ll be sent for an advanced type of MRI scan known as I really hope that achievements and aims. mpMRI and, if needed, a biopsy. By the end of the trial, we hope to be absolutely devastating – he’s the apple of Professor Hash Ahmed from Imperial College London will be leading able to see how many aggressive cancers are detected by each of the my eye,” Tony says. “Prostate cancer has within a few years’ the trial. He co-led the ground-breaking PROMIS trial that built on tests and how many men they sent for further tests unnecessarily. had a devastating impact on our family, we our earlier research and led to widespread use of mpMRI scans

lead a completely different life.” time, by the time my Pull here We need to see how well these around the country. There is also a small tests work across a wide population Tony has semi-retired so that he can spend son is in his 40s, that “In the UK, we are leading the world in in combination with mpMRI scans more time with his family. But this time having a national implementation of mpMRI and within the structure of the NHS of year is particularly hard, “Christmas we have a screening and targeted biopsy. As a result of all the insert included in the before we can have a national has been really challenging since being work the UK has done in diagnosis, we have screening programme. diagnosed with prostate cancer, because programme in place. Keeping families I’m wondering how many more am I going a once in a lifetime opportunity to give men pack, resembling a to see?” he says. Tony and family Tony Collier more time with their families,” he says. together at Christmas cracker joke, featuring a prostate cancer

related trivia question. Breast cancer PSA first used for diagnosis. We start funding research into PROMIS We start to establish trial to combine new Pilot phase of trial A biobank of samples European Age- Although concerns are using mpMRI to avoid unnecessary results show tests, including mpMRI, to prove whether completes to show that from PREDICT are saved Standardised known about its accuracy, biopsies, providing evidence that mpMRI they are good enough to have a screening recruitment is on track and so that in future newer Mortality rates it’s the best test available. leading to the PROMIS trial. can reduce programme for prostate cancer in the NHS. the process is feasible. ways to diagnose prostate in the UK. unnecessary cancer can be tested biopsies. My prostate cancer against current tools. 1988 1995 2010 2019 2024 1971 1988 2016 was only diagnosed when it was too late. A screening programme Breast cancer Early Our first grant into 2008 One of our previous 2017 2018 2020 Onwards screening genetics research helps PhD students, Hayley Trial begins recruitment. Recruitment to trial finishes and begins in the 1990s understand each man’s Whitaker, develops a test could SAVE many GP surgeries sign up results are analysed to see the UK, saving risk of prostate cancer. Our for a blood biomarker to take part and send accuracy of these tests. If the results thousands continued research discovers that could be used for thousands of lives. out invitations to men are as hoped, we call for a screening Phil Graham of lives. hundreds of genes involved. prostate cancer diagnosis. Tony Collier eligible for the trial. programme for prostate cancer. 07941 508026 [email protected] PROJECT Trinity School Community Partnerships 3 210 x 210mm booklet 40 DESCRIPTION 16 page booklet outlining the school’s contribution in the local community. 15 2

4 5

20 3 200

Over 4 150 80 17

240

6 7 8 9

Over 876 £6,700

200,000 3 87

650

Phil Graham £59,848 29 3 07941 508026 10 11 12 13 [email protected] PROJECT Prostate Cancer UK Gala Dinner branding

DESCRIPTION FRONT MOCK UP ARTWORK BACK The theme for the Gala Dinner was ‘Fairground’. 14 SEPTEMBER 2017 ras nn a For the ticket the word

‘GALA’ and line at the eals a top were sliver foiled and it had a soft touch finish with intermittent Canery ane lrn lamination to create the tatin e Caner ane ‘star-burst’ effect. lbrn tatin i lbrn This branding was used throughout the event on nswa the brochure, screens, table plan etc.

Thursday 14 September 2017 Reception: 6.45pm Rosewood Carriages: 11.30pm High Holborn Dress code: Black Tie London WC1V 7EN

ADMITS ONE Prostate Cancer UK is a registered charity in England and Wales (1005541)

and in Scotland (SC039332). Registered company number 2653887. 4787

Ticket front

Phil Graham 07941 508026 [email protected] PROJECT Society of London Theatre - Olivier Awards

240 x 340mm, 40 YEARS OF MUSICALS AT THE OLIVIER AWARDS it proved its award was right the Oliviers demonstrates that West End does, it’s an encouraging when it returned five years musicals have held their own against Broad- sign that British shows can later in a different production go into competition with 108 page Brochure way’s best from the very beginning at the Albery (now Noël them so confidently. Coward) that then ran for

REX FEATURES: JONATHAN HORDLE JONATHAN FEATURES: REX nearly a quarter of a century there and at the Phoenix, The very first award for Musical of the Year in 1976 went finally closing in 2012 as the third longest-running musical in to A Chorus Line — Broadway’s greatest valentine to the West End history. rank-and-file of the people who help make musicals great -- but just two years later, Andrew Lloyd Webber and Tim Meanwhile, the musical that actually holds that title, Les Rice’s Evita would triumph and be followed in the 1980s Misérables — now in its 31st West End year at the Queen’s by Olivier wins for Cats, The Phantom Of The Opera and DESCRIPTION Theatre — lost the Olivier Award in 1985 to Me And My Me And My Girl, all of which would go on to Broadway, Girl; it would take the 1987 Tony Awards to reverse that and the first two of which would earn Tony wins for Best when both Les Mis and Me And My Girl transferred to Musical as well. Broadway, and Les Mis emerged the victor. Designing the layout During the last 40 years of the Olivier Awards, the West End musical has truly come of age. Though shows like Oliver! and The Boy Friend, which came long before the PAUL COLTAS Oliviers were founded, had achieved some success on and collating text, Broadway during their time, the Oliviers demonstrates that West End musicals have held their own against Broadway’s best from the very beginning and have forged their own images and adverts distinctive path. 40 YEARS OF MUSICALS AT THE OLIVIER AWARDS Yet our musical borders are far from closed to Broadway. Since the Oliviers were founded in 1976 (then known as from multiple sources. the Society of Awards), we’ve seen BY MARK SHENTON British-originated shows win the Best Musical award Joint lead critic of The Stage, as well as Associate Editor, and chairman of the drama section of the Critics’ Circle 19 times against the exact same number of Broadway imports. That split continues tonight, with the nominees for Mrs Henderson Presents The Olivier Awards has become London’s direct equivalent open-ended runs that will see them occupying a theatre this year’s awards seeing two Broadway imports (Kinky to the Tony Awards: presented by the theatre industry to continuously for as long as the business demands. Boots and In The Heights) going head-to-head against recognise its own biggest achievements of the theatrical two original British musicals (Bend It Like Beckham and New York would also welcome such Olivier losers as the year, in one of the West End’s most impressive and historic Just as the award that really counts, commercially speaking, Mrs Henderson Presents). aforementioned Les Misérables, Miss Saigon (losing in venues (the where we are sitting on Broadway is the one given for Best Musical, the same London to Return To The Forbidden Planet in 1989/90) and tonight, as opposed to the now usual home of the Tonys at Olivier category now has serious commercial clout, too, in In as much as Broadway continues to produce far more Mamma Mia! (losing to Honk! in 2000), all of which would Radio City Music Hall). terms of extending a musical’s life or giving a new musical a original musicals on an annual basis than the West End ever become long-running New York successes — Mamma heads start on a touring or international life. They can, quite Mia! has only just closed there last summer, while Les There’s both an artistic and financial stake to their results. literally, help to repay the investment made in their creation. Misérables has already had its second Broadway return They reward excellence, of course, but they also confer a Last year’s Olivier-winning Sunny Afternoon is to set off on and Miss Saigon is also set to go back to Broadway in a stamp of approval that can transform a show’s fortunes, in a UK tour, opening in Manchester in August; the 2013 transfer of its recent West End incarnation. But if Broadway every sense. Musicals are big business, in fact, they’re the winner Top Hat has travelled to the Far East and has since ELLIE KURTTZ has regularly embraced British musicals — and the RSC’s biggest part of the business in the West End. 8,266,104 embarked on a second UK tour. hit Matilda The Musical is currently a hit on both sides of people saw a musical in the West End last year, generating the Atlantic — it has comparatively rarely rewarded them: some £385m in revenue (as opposed to plays, seen by just It is frequently said that history is written by the victors, so only six British musicals have earned Broadway’s top Tony under half as many people, with attendances of 4,116,250, the Oliviers provide a history of the last 40 years of some of honour for best musical since 1976 (against 34 American spending £141m). So they’re a major driver of traffic in terms the greatest triumphs in musicals, and also some signposts entries). Yet those six also include some significant victories of both people and money in the West End. But they also about trends and fashions. The winning entries provide the over a couple of original Broadway shows that have cost a whole lot more to put on; the stakes are far higher. headlines, but not the full story by any means. The original themselves become classics of their kind: Sondheim and And they typically play a production of Willy Russell’s Lapine’s original production of Into The Woods lost to The much longer game: while They reward excellence, of course, but Blood Brothers, which won Phantom Of The Opera in 1988, and more recently Next plays are nowadays routinely they also confer a stamp of approval that the Olivier for Best Musical To Normal lost to Billy Elliot The Musical in 2009. programmed to run for of the Year in 1983, only ran 12-14 weeks only, musicals can transform a show’s fortunes, for six months at Shaftesbury But then the history of awards are often the story of major are still typically booked for in every sense Avenue’s Lyric Theatre, but Bend It Like Beckham upsets: on Broadway, Gypsy lost the Tony Award to a tie

22 23

BEST COSTUME DESIGN MATT CROCKETT

GREGG BARNES SUNDAY 3 APRIL 2016 • ROYAL OPERA HOUSE for Kinky Boots at TRISTRAM KENTON

HUGH DURRANT

for Nell Gwynn at MARC BRENNER

JONATHAN FENSOM

for Farinelli And The King at Duke of York’s Theatre ELLIE KURTTZ

KATRINA LINDSAY

for Bend It Like Beckham at Phoenix Theatre 1

37

Phil Graham 07941 508026 [email protected] PROJECT Official London Theatre website graphics

DESCRIPTION Mamma Mia! and Olivier Awards website infographics

Phil Graham 07941 508026 [email protected] PROJECT The co-operative Business Travel website infographic

continued... Phil Graham 07941 508026 [email protected]