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Supplement RAND Appropriateness Panel to Determine The BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Thorax Supplement RAND appropriateness panel to determine the applicability of UK guidelines on the management of acute respiratory distress syndrome (ARDS) and other strategies in the context of the COVID-19 pandemic ǂ*Mark JD Griffiths FRCP1,2,3, *Susanna Meade MB ChB 4, *Charlotte Summers PhD5, *Danny F McAuley MD6, *Alastair G Proudfoot FRCP1,3,8, Marta Montero Baladia9, Paul Dark PhD10, Kate Diomede MB ChB11 Simon J. Finney FRCA1,3, Lui G Forni PhD12, Christopher Meadows FRCP 4, Ian A Naldrett MSc13,14, Brijesh V. Patel FFICM14,15 Gavin D. Perkins MD16, Mark A Samaan MB BS4, Laurence Sharifi FRCA9, Ganesh Suntharalingam FRCA17,18, Nicholas T Tarmey FFICM19, Matt P Wise DPhil20, Harriet F Young MRCP1, Peter M Irving MD4,7 1 Barts Heart Centre, St Bartholomew’s Hospital, London, UK. 2 National Heart & Lung Institute, Imperial College London, London, UK. 3 William Harvey Research Institute, Queen Mary University of London, London, UK. 4 Guy’s and St Thomas’ NHS Foundation Trust, London, UK. 5 Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 6 Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast and Regional Intensive Care Unit, Royal Victoria Hospital, Belfast UK. 7 School of Immunology and Microbial Sciences, King's College London, UK. 8 Nightingale Hospital, London, UK. 9 Barts & The London School of Anaesthesia, The Royal London Hospital, Whitechapel, London, E1 1BB, UK. 10 Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR Biomedical Research Centre, University of Manchester, UK. 11 East Kent Hospitals NHS Foundation Trust, UK. 12 Department of Clinical & Experimental Medicine, Faculty of Health Sciences, University of Surrey & Intensive Care Unit, Royal Surrey Foundation Trust, Guildford, Surrey, UK. 13 College of Nursing, Midwifery and healthcare, University of West London, UK. 14 Adult Critical Care Units, Royal Brompton & Harefield NHS Foundation Trust, UK. Griffiths M, et al. Thorax 2021;0:1–7. doi: 10.1136/thoraxjnl-2021-216904 BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Thorax 15 Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK. 16 Warwick Clinical Trials Unit, University of Warwick, Coventry, UK. 17 Intensive Care Society, London, UK. 18 London North West University Healthcare NHST, London, UK. 19 Academic Department of Critical Care, Portsmouth Hospitals University NHS Trust, UK. 20 University Hospital of Wales, Cardiff, CF14 4XW, UK. *These authors have contributed equally ǂ Corresponding author: Mark Griffiths Barts Heart Centre King George V Building St Bartholomew’s Hospital West Smithfield London EC1A 7BE Mobile: 07875 999126 Barts: 0203 765 8054 Email: [email protected] Griffiths M, et al. Thorax 2021;0:1–7. doi: 10.1136/thoraxjnl-2021-216904 BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Thorax Literature Search Results L., Munshi, Fan E., and Walkey A. 2014. “Reply.” Annals of the American Thoracic SocietyAnnals of the American Thoracic Society 11(6):993–95. J., Xiao, Price J., and Mina N. 2018. “Human Coronavirus OC43-Induced Acute Respiratory Distress Syndrome.” Critical Care Medicine 46:509. K.C., Sumino, Walter M.J., Mikols C.L., Agapov E., Holtzman M.J., Thompson S.A., Gaudreault-Keener M., Arens M.Q., Hormozdi D., Storch G.A., and Gaynor A.M. 2010. “Detection of Respiratory Viruses and the Associated Chemokine Responses in Serious Acute Respiratory Illness.” ThoraxThorax 65(7):639–44. Liang, Yanwen, Mong-Lien Wang, Chian-Shiu Chien, Aliaksandr A. Yarmishyn, Yi- Ping Yang, Wei-Yi Lai, Yung-Hung Luo, Yi-Tsung Lin, Yann-Jang Chen, Pei-Ching Chang, Shih-Hwa Chiou, Liang Y., Wang M.-L., Chien C.-S., Yarmishyn A.A., Yang Y.-P., Lai W.-Y., Chiou S.-H., Chen Y.-J., Luo Y.-H., Lin Y.-T., and Chang P.-C. 2020. “Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection.” Frontiers in ImmunologyFrontiers in Immunology 11:1022. R., Pal. 2020. “COVID-19, Hypothalamo-Pituitary-Adrenal Axis and Clinical Implications.” EndocrineEndocrine 68(2):251–52. Tian, Dandan, and Qing Ye. 2020. “Hepatic Complications of COVID-19 and Its Treatment.” Journal of Medical Virology. M.K., Han, and Hyzy R.C. 2007. “The Role of Corticosteroids in Sepsis and Acute Respiratory Distress Syndrome.” Current Respiratory Medicine Reviews 3(2):141–46. NCT04401150. 2020. “Lessening Organ Dysfunction With VITamin C - COVID-19.” Https://Clinicaltrials.Gov/Show/NCT04401150. A., Hadadi, Mortezazadeh M., Kolahdouzan K., Alavian G., Azar Hadadi, Masoud Mortezazadeh, Kasra Kolahdouzan, and Golbarg Alavian. 2020. “Does Recombinant Human Erythropoietin Administration in Critically Ill COVID-19 Patients Have Miraculous Therapeutic Effects?” Journal of Medical Virology 92(7):915–18. M.P., Stevens, Patel P.K., and Nori P. 2020. “Involving Antimicrobial Stewardship Programs in COVID-19 Response Efforts: All Hands on Deck.” Infection Control and Hospital EpidemiologyInfection Control and Hospital Epidemiology 41(6):744–45. A., Coppo, Cairo M., Contro E., Benini A., Bellani G., Winterton D., Di Pierro M., Foti G., Soria A., Faverio P., Mori S., Valsecchi M.G., Antolini L., Messinesi G., and Bonfanti P. 2020. “Feasibility and Physiological Effects of Prone Positioning in Non- Intubated Patients with Acute Respiratory Failure Due to COVID-19 (PRONCOVID): A Prospective Cohort Study.” The Lancet. Respiratory Medicine. Kobayashi, Jun, Isamu Murata, Kobayashi J., and Murata I. 2020. “Nitric Oxide Inhalation as an Interventional Rescue Therapy for COVID-19-Induced Acute Griffiths M, et al. Thorax 2021;0:1–7. doi: 10.1136/thoraxjnl-2021-216904 BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Thorax Respiratory Distress Syndrome.” Annals of Intensive CareAnnals of Intensive Care 10(1):61. M.A., Wujtewicz, Dylczyk-Sommer A., Aszkielowicz A., Owczuk R., Zdanowski S., and Piwowarczyk S. 2020. “COVID-19 - What Should Anaethesiologists and Intensivists Know about It?” Anaesthesiology Intensive TherapyAnaesthesiology Intensive Therapy 52(1):34–41. J.-C., Song, Wang G., Zhang W., Zhang Y., Zhou Z., and Li W.-Q. 2020. “Chinese Expert Consensus on Diagnosis and Treatment of Coagulation Dysfunction in COVID-19.” Military Medical Research 7(1). Malhotra, Atul, David Ernest, Benjamin A. Rogers, David Haylock, Ashalyn Watt, Guy Moeneclaey, and Graham Jenkin. 2020. “Umbilical Cord Blood Therapy to Prevent Progression of COVID-19 Related Pneumonia: A Structured Summary of a Study Protocol for a Pilot Randomised Controlled Trial.” Trials 21(1):474. NCT04401293. 2020. “Full Dose Heparin Vs. Prophylactic Or Intermediate Dose Heparin in High Risk COVID-19 Patients.” Https://Clinicaltrials.Gov/Show/NCT04401293. NCT04317040. 2020. “CD24Fc as a Non-Antiviral Immunomodulator in COVID-19 Treatment.” Https://Clinicaltrials.Gov/Show/NCT04317040. J.M., Grimes, Grimes K.V., Joseph M. Grimes, and Kevin V Grimes. 2020. “P38 MAPK Inhibition: A Promising Therapeutic Approach for COVID-19.” Journal of Molecular and Cellular CardiologyJournal of Molecular and Cellular Cardiology 144:63–65. NCT04418518. 2020. “A Trial of CONvalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness.” Https://Clinicaltrials.Gov/Show/NCT04418518. D.M.G., Halpin, Singh D., and Hadfield R.M. 2020. “Inhaled Corticosteroids and COVID-19: A Systematic Review and Clinical Perspective.” European Respiratory JournalEuropean Respiratory Journal 55(5). E.J., Marquez, Trowbridge J., Kuchel G.A., Banchereau J., and Ucar D. 2020. “The Lethal Sex Gap: COVID-19.” Immunity and AgeingImmunity and Ageing 17(1). NCT04384445. 2020. “Organicell Flow for Patients With COVID-19.” Https://Clinicaltrials.Gov/Show/NCT04384445. Barnes, Betsy J., Jose M. Adrover, Amelia Baxter-Stoltzfus, Alain Borczuk, Jonathan Cools-Lartigue, James M. Crawford, Juliane Dasler-Plenker, Philippe Guerci, Caroline Huynh, Jason S. Knight, Massimo Loda, Mark R. Looney, Florencia McAllister, Roni Rayes, Stephane Renaud, Simon Rousseau, Steven Salvatore, Robert E. Schwartz, Jonathan D. Spicer, Christian C. Yost, Andrew Weber, Yu Zuo, and Mikala Egeblad. 2020. “Targeting Potential Drivers of COVID-19: Neutrophil Griffiths M, et al. Thorax 2021;0:1–7. doi: 10.1136/thoraxjnl-2021-216904 BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Thorax Extracellular Traps.” The Journal of Experimental Medicine 217(6). Joshi, Avni Y., Roshini M. Mullakary, and Vivek N. Iyer. 2020. “Successful Treatment of Coronavirus Disease 2019 in a Patient with Asthma.” Allergy and Asthma Proceedings 41(4):296–300. H.-J., Liu, and Shi H.-Z. 2009. “Major Advances
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