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Essential Oil of Kunzea Ambigua and Methods Of (19) TZZ _ _ _T (11) EP 2 192 912 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61P 33/10 (2006.01) A61P 1/00 (2006.01) 01.06.2016 Bulletin 2016/22 A61P 19/06 (2006.01) A61K 36/61 (2006.01) (21) Application number: 08733387.8 (86) International application number: PCT/AU2008/000560 (22) Date of filing: 22.04.2008 (87) International publication number: WO 2008/128295 (30.10.2008 Gazette 2008/44) (54) ESSENTIAL OIL OF KUNZEA AMBIGUA AND METHODS OF USE ESSENTIELLES ÖL VON KUNZEA AMBIGUA UND ANWENDUNGSVERFAHREN HUILE ESSENTIELLE DE KUNZEA AMBIGUA ET PROCÉDÉS D’UTILISATION (84) Designated Contracting States: • BLOOR S J: "ANTIVIRAL PHLOROGLUCINOLS AT BE BG CH CY CZ DE DK EE ES FI FR GB GR FROM NEW ZEALAND KUNZEA SPECIES", HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT JOURNAL OF NATURAL PRODUCTS, RO SE SI SK TR AMERICAN CHEMICAL SOCIETY, US, vol. 55, no. 1, 1 January 1992 (1992-01-01), pages 43-47, (30) Priority: 23.04.2007 AU 2007902118 P XP000905508, ISSN: 0163-3864, DOI: DOI:10.1021/NP50079A006 (43) Date of publication of application: • LIS-BALCHIN M ET AL: "Pharmacological and 09.06.2010 Bulletin 2010/23 antimicrobial studies on different tea-tree oils (Melaleuca alternifolia, Leptospermum (73) Proprietor: Hood, John James David scoparium or manuka and Kunzea ericoides or Waterhouse TAS 7262 (AU) Kanuka), originating in Australia and New Zealand", MEDICINAL & AROMATIC PLANTS (72) Inventor: Hood, John James David ABSTRACTS, SCIENTIFIC PUBLISHERS, Waterhouse TAS 7262 (AU) SCIENTIFIC PUBLISHERS, NEW DELHI - INDIA, vol. 23, no. 2, 1 April 2001 (2001-04-01), (74) Representative: Evans, Huw David Duncan XP018013444, ISSN: 0250-4367 chapman+co • LIS-BALCHIN M ET AL: "BIOACTIVITY OF NEW Cardiff Business Technology Centre ZEALAND MEDICINAL PLANT ESSENTIAL Senghennydd Road OILS", ACTA HORTICULTURAE, Cardiff CF24 4AY (GB) INTERNATIONAL SOCIETY FOR HORTICULTURAL SCIENCE, BE, no. 426, 1 (56) References cited: January 1996 (1996-01-01), pages 13-30, WO-A1-98/17749 XP002055778, ISSN: 0567-7572 • KHAMBAY B P S ET AL: "An insecticidal mixture • VEECH T: "Newsletter August 05", INTERNET of tetramethylcyclohexenedione isomers from CITATION, August 2005 (2005-08), XP008132031, Kunzea ambigua and Kunzea baxterii", Retrieved from the Internet: PHYTOCHEMISTRY, PERGAMON PRESS, GB, URL:http://www.naturalsolutionsbytia.com/u vol. 59, no. 1, 1 January 2002 (2002-01-01), pages ploads/Newsletter%20August%2005.pd 69-71, XP004326317, ISSN: 0031-9422, DOI: [retrieved on 2011-01-21] DOI:10.1016/S0031-9422(01)00410-1 Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). EP 2 192 912 B1 Printed by Jouve, 75001 PARIS (FR) (Cont. next page) EP 2 192 912 B1 • ITO H ET AL: "Kunzeanones A, B, and C: novel • HIDEYUKI I. ET AL.: ’dimeric Flavonol Glycoside alkylated phloroglucinol metabolites from and Galloylated C-Glucosylchromones from Kunzea ambigua", TETRAHEDRON, ELSEVIER Kunzea ambigua’ JOURNAL OF NATURAL SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. PRODUCTS vol. 67, no. 3, 2004, pages 411 - 415, 60, no. 44, 25 October 2004 (2004-10-25), pages XP008132034 9971-9976, XP004580198, ISSN: 0040-4020, DOI: DOI:10.1016/J.TET.2004.08.027 Remarks: • KNIGHT G.: ’Essential OIls’ KNOW YOURSELF, Thefile contains technical information submitted after HEAL YOURSELF, [Online] 08 December 2006, the application was filed and not included in this pages 1 - 4, XP055204966 Retrieved from the specification Internet: <URL:http://www.web.archive.org/web/2006120 8112032/http://www.knowyourselfhealyourself . com/oils.shtml> • VEECH T.: ’Newsletter August 05’ NATURAL SOLUTIONS BY TIA, [Online] August 2005, XP008132031 Retrieved from the Internet: <URL:http://www.naturalsolutionsbytia.com/u ploads/Newsletter%20August%2005.pdf> 2 1 EP 2 192 912 B1 2 Description and wrist. External application in these areas gives good results but is slow as the passage of oil through the skin [0001] This invention relates to an improved medica- in these areas is slow. He took 5-6 drops of Kunzea am- tion. bigua in water or fruit juice each morning and in 11 days [0002] Australian Patent 721156 entitled ESSENTIAL 5 theswelling hadregressed and the pain was substantially OIL AND METHODS OF USE describes an essential oil relieved. The client in this case also took conventional from the Kunzea ambigua and its topical use for the treat- pain killers during the early part of the treatment but after ment of various conditions. five days could be stopped. [0003] Further experimentation has shown unexpect- [0017] The oil has been laboratory tested against vi- ed results in the use of the oil in internal applications and 10 ruses and it has shown a very high kill rate. It is believed the object of the present invention is to develop such use. that the oil is efficacious against many diseases caused [0004] The invention includes the use of the essential by internal germs and viruses. oil from the Kunzea ambigua in internal applications for [0018] The oil can also be successfully used against the treatment of medical conditions. parasite attacks in animals. [0005] Specifically it has been found that the oil acts 15 [0019] In Europe, and specifically in France, essential positively against parasitic infestation of humans and an- oils are used by mainstream doctors, are prescribed by imals, and against certain other conditions, as set out in them for treating certain diseases, the prescriptions are the claims. made up by pharmacists, are used internally in many [0006] Specifically, the present invention comprises a applications and are used at higher rates than have gen- dosage regimen for internal administration, which com- 20 erally been the case in Britain, Australia and the United prises essential oil of Kunzea ambigua, in an amount of States of America. 2 to 15 drops, for administration and treatment of various [0020] Trials of the use of kunzea oil have been carried conditions as defined in claim 1. Preferred dosage regi- out in France by Dr Daniel Penoel, a leading practitioner mens are defined in the remaining claims. in this field. These trials have been clinically based and [0007] In order that the invention may be more readily 25 have been done without external funding. understood, applications of the invention and basis there- [0021] Dr Penoil states for will now be described. [0008] A first patient was suffering substantial weight ’Using kunzea ambigua in diluted form and in exter- loss over a relatively short period (from 95Kg to 88Kg) nal applications can only reveal some possibilities. [0009] The patient was originally suspected of having 30 Obviously using higher concentrations and using it a thyroid malfunction, but tests did not show more than internally opens a completely new area of a minor irregularity and a second diagnoses was lung applications. .... What was done withkunzea am- cancer (although this was not indicated by X-ray). bigua in this medical context confirmed that it has a [0010] A second opinion was sought and the medical very strong power.’ practitioner did certain tests and weighed the patient and 35 asked him to return for the test results after a short period. [0022] As a result of these trials, Dr Penoel has report- [0011] During this period, the patient self medicated ed: and settled on taking two doses a day of seven to eight drops of the Kunzea ambigua oil in 16mL of water, gar- Kunzea ambigua taken internally has shown a very gled and then swallowed. 40 strong action on a certain number of viral conditions [0012] The results were dramatic, the patient gained weight at a rate of some 0.5 Kg per day. 1. kunzea ambigua has shown a strong effect [0013] It is the patient’s belief that he was, in fact, in- on the cleansing of arteries that were partially fested with parasites and the kunzea ambigua oil killed clogged by atheromatosis plaques the infestation and enabled his digestive system to op- 45 erate normally. The treatment was discontinued after ap- 2. kunzea ambigua has shown a powerful action proximately one week on the assumption that the weight on degenerative conditions involving certain gain indicated that the cause of the loss had been re- forms of cancers (veterinary medicine). moved. After several years the problem has not reoc- curred. 50 3. kunzea ambigua has shown a very strong ac- [0014] It is believed that the oil acted as a highly effec- tion on inflammatory processes, including in- tive anthelmintic. flammation linked with auto-immune diseases, [0015] A middle aged man with irritable bowel syn- in particular Crohn’s disease. drome self medicated with 4 drops each of Kunzea am- bigua and Fragonia (Agonis fragrans) oils three times a 55 4. kunzea ambigua has shown a very strong ac- day with food. Within a week, the symptoms of the dis- tion, for some receptive patients, on the psyche, ease disappeared. to give strength and resilience. [0016] A 65 year old man had severe gout in the fingers 3 3 EP 2 192 912 B1 4 5. kunzea ambigua has shown a very strong ac- Agonis fragrans for administration three times per tion on consequences of chronic viral infections, day with food. like EBV (glandular fever), with results that no pharmaceutical synthetic molecule can achieve. 5 Patentansprüche 6. Kunzea ambigua has shown a positive action on the liver function.
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