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Curriculum Vitae LEE Curriculum Vitae LEE ZOU 1. General Information Primary Position: Associate Professor of Pathology Harvard Medical School Office Address: Massachusetts General Hospital Cancer Center Room 7404, Building 149, 13th Street Charlestown, MA 02129 Work email: [email protected] Work phone/fax: (617) 724-9534 / (617) 726-7808 2. Education and Training Education: 1999 Ph.D. Stony Brook University & Cold Spring Harbor Laboratory, New York (with Dr. Bruce Stillman, F.R.S.) 1994 M.S. Kansas State University, Kansas 1992 B.S. Sun Yet-Sen (Zhongshan) University, China Postdoctoral Training: 2000-2003 HMMI Associate/Postdoctoral Fellow (with Dr. Stephen Elledge) Department of Biochemistry Baylor College of Medicine (Named fellow, Damon Runyon Cancer Research Fund) 2003-2004 Research Fellow (with Dr. Stephen Elledge) Harvard Partners Center for Genetics and Genomics Brigham & Women’s Hospital/Harvard Medical School 3. Past and Current Positions 2004-2009 Assistant Professor of Pathology, Harvard Medical School 2004- Assistant Geneticist, Massachusetts General Hospital, Boston, MA 2004- Member, Massachusetts General Hospital Cancer Center 2005- Member, Ph.D. Program in Biological and Biomedical Science, Harvard Medical School 2006- Member, Dana-Farber/Harvard Cancer Center 2007- Member, Leder Human Biology and Translational Medicine Program, Harvard Medical School 2008- Assistant in Radiation Oncology, Massachusetts General Hospital 2009- Associate Professor of Pathology, Harvard Medical School 4. Honors and Awards 1998 Sigma Xi Award for Excellence in Research, Stony Brook University 1998 Abrahams Award for Outstanding Scientific Achievement by a Graduate Student, Stony Brook University 1998 Elected Associate Member, Sigma Xi, the Scientific Research Society 1999 The Harold Weintraub Graduate Student Award Nominee, Cold Spring Harbor Laboratory 2000 Fellow*, the Jane Coffin Child Memorial Fund for Medical Research 2000 Fayez Sarofim Fellow (named fellow), the Damon Runyon Cancer Research Fund 2001 The V. C. Joshi Memorial Award, Baylor College of Medicine 2002 The V. C. Joshi Memorial Award, Baylor College of Medicine 2004 Biological Science Scholar*, University of Michigan Medical School 2004 Whitehead Fellow*, Duke University Medical Center 2004 Pew Scholar Nominee, Massachusetts General Hospital 2004 The Smith Family New Investigator Award, the Medical Foundation 2005 V Scholar, the V Foundation for Cancer Research 2005 Young Investigator Award, Breast Cancer Alliance 2005 Searle Scholar Nominee, Harvard Medical School 2006 W. M. Keck Distinguished Young Scholar Nominee*, Harvard University 2006 Isselbacher Scholar Award, Massachusetts General Hospital 2007 National Finalist for Rita Allen Scholar, the Rita Allen Foundation 2007 Ellison New Scholar in Aging, the Ellison Medical Foundation 2008 American Cancer Society Research Scholar 2008 The OSD Seminar Speaker, National Institute on Aging, NIH 2009 The John H. Blaffer Lecture Speaker, M. D. Anderson Cancer Center 2009 The John B. Little Symposium Speaker, Harvard School of Public Health 2009 The One Hundred Award, MGH Cancer Center 2009 Member, Faculty of 1000 * These offers were declined. 5. Publications 1. Zou, L., Mitchell, J. and Stillman, B. (1997) CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication. Mol. Cell Biol. 17: 533-563. 2. Zou, L. and Stillman, B. (1998) Formation of a preinitiation complex by S-phase cyclin-CDK activated loading of Cdc45p onto chromatin. Science 280: 293-296. 3. Zou, L. and Stillman, B. (2000) Assembly of a complex containing Cdc45p, Replication Protein A and Mcm2p at replication origins controlled by S-phase Cyclin-Dependent Kinases and Cdc7p-Dbf4p Kinase. Mol. Cell Biol. 20: 3086- 3096. 4. Zou, L., Guo, S. Y., and Davis, L. C. (2000) Using electrophoresis to observe the interaction of nitrogenase with ions. Electrophoresis 21:2932-2939. 5. Zou, L., Baguinon, M. C., Guo, G., Guo, S. Y., Yu, Y., and Davis, L. C. (2000) Interaction with magnesium and ADP stabilizes both components of nitrogenase from Klebsiella pneumoniae against urea denaturation. Protein Science 9:211- 218. 6. Zou, L., Cortez, D. and Elledge, S.J. (2002) Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes & Dev. 16: 198-208. 7. Osborn, A. J., Elledge, S. J. and Zou, L. (2002) Checking on the fork: the DNA- replication stress-response pathway. Trends in Cell Biol. 12:509-16. 8. Wang, X., Zou, L., Zheng, H., Wei, Q., Elledge, S. J., and Li, L. (2003) Genomic instability and endoreduplication triggered by Rad17 deletion. Genes & Dev. 17:965-70. 9. Zou, L. and Elledge, S.J. (2003) Sensing and signaling DNA damage: roles of Rad17 and Rad9 complexes in checkpoint response. The Harvey Lectures, Series 97: 1-15. 10. Zou, L. and Elledge, S. J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA Complexes. Science (Research Article) 300:1542-49. 11. Zou, L., Liu, D., and Elledge, S. J. (2003) RPA-mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. USA 25:13827-32. 12. Li, L. and Zou, L. (2005) Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells. J. Cell. Biochem. 94(2): 298-306. 13. Yang, X.H. and Zou, L. (2006) Checkpoint and Coordinated Cellular Response to DNA Damage. Results Probl. Cell Differ. 42:65-92. 14. Yang, X. H. and Zou, L. (2006) Recruitment of ATR-ATRIP, Rad17, and 9-1-1 complexes to DNA damage. Methods Enzymol. 409:118-131. 15. Namiki, Y., and Zou, L. (2006) ATRIP associates with replication protein A-coated single-stranded DNA through multiple interactions. Proc. Natl. Acad. Sci. USA 103:580-585. 16. Wang, X., Zou, L., Lu, T., Bao, S., Hurov, K. E., Hittleman, W. N., Elledge, S. J. and Li, L. (2006) Rad17 phosphorylation is required for Claspin recruitment and Chk1 activation in response to replication stress. Mol. Cell 23:331-341. 17. Zou, L. (2007) Single- and double-stranded DNA: building a trigger of ATR- mediated DNA damage response. Genes & Dev. 21:879-885. 18. Yang, X. H., and Zou, L. (2007) Launching a ubiquitination cascade at DNA Breaks. Proc. Natl. Acad. Sci. USA 104:20649-20650. 19. Yang, X. H., and Zou, L. (2008) Sensing of DNA damage. Wiley Encyclopedia of Chemical Biology. 20. Yang, X. H., Shiotani, B., Classon, M., and Zou, L. (2008) Chk1 and Claspin potentiate PCNA ubiquitination. Genes & Dev. 22:1147-1152. 21. Yang, X. H. and Zou, L. (2009) Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination. Cell Cycle 8:191-194. 22. Shiotani, B. and Zou, L. (2009) ATR signaling at a glance. J. Cell Sci. 122:301- 304. 23. Shiotani, B., and Zou, L. (2009) Single-stranded DNA orchestrates an ATM-to- ATR switch at DNA breaks. Mol. Cell 33:547-558 (a featured article and the cover story) 24. Zhang, J., Song, Y. H., Brannigan, B. W., Wahrer, D. C. R., Schiripo, T. A., Harris, P. L., Haserlat, S. M., Ulkus, L. E., Shannon, K. M., Garber, J. E., Freedman, M. L., Henderson, B. E., Zou, L., Sgroi, D. C., Haber, D. A., and Bell, D. W. (2009) Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin (CLSPN). Mol. Cancer Res. 9:1510-1516. 25. Zou, L. (2009) Checkpoint Mec-tivation comes in many flavors. Mol. Cell 36:734- 735. 26. Sharma, S. V., Lee, D. Y., Li, B., Quinian, M. P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M., A., Wong, K., Brandstetter, K., Wittner, B., Ramaswamy, S., Classon, M., and Settleman, J. (2010) A Chromatin- Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations. Cell 141:69-80. 27. Shiotani, B. and Zou, L. (2010) A Human Cell Extract-Based Assay for the Activation of ATM and ATR Checkpoint Kinases. Methods Mol. Biol. (In press) 28. Flynn, R. L., and Zou, L. (2010) Oligonucleotide/Oligosaccharide-Binding (OB) Fold Proteins: A Growing Family of Genome Guardians. Critical Rev. Biochem. Mol. Biol. (In press) 29. Yanagihara, H., Kobayashi, J., Tateishi, S., Kato, A., Tauchi, H., Zou, L., Sugasawa, K., Masutani, C., Hanaoka, F., Mori, T., Matsuura, S., and Komastu, K. (2010) RAD6-Like Domain of NBS1 Mediates RAD18 Relocalization to Chromatin after UV Exposure. (Submitted) 30. Huang, M., Kim, J. M., Shiotani, B., Yang, K., Zou, L., and D’Andrea, A. D. (2010) The FANCM/FAAP24 Complex is Required for the DNA Interstrand Crosslink- Specific Checkpoint Response. (Submitted). 31. Flynn R. L., Tse A., Songyang, Z., and Zou, L. (2010) Telomere-Specific ATR Repression by POT1-Mediated RPA Displacement. (Submitted). 32. Centore, R. C., Havens, G. C., Tse, A., Walter, J., and Zou, L. (2010) CRL4Cdt2- Dependent Destruction of the Set8 Histone Methyltransferase in S Phase and after DNA Damage. (submitted) .
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