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2020 Annual Report

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2020 Annual Report 2020 ANNUAL REPORT About IHV The Institute of Human Virology (IHV) is the first center in the United States—perhaps the world— to combine the disciplines of basic science, epidemiology and clinical research in a concerted effort to speed the discovery of diagnostics and therapeutics for a wide variety of chronic and deadly viral and immune disorders—most notably HIV, the cause of AIDS. Formed in 1996 as a partnership between the State of Maryland, the City of Baltimore, the University System of Maryland and the University of Maryland Medical System, IHV is an institute of the University of Maryland School of Medicine and is home to some of the most globally-recognized and world- renowned experts in the field of human virology. IHV was co-founded by Robert Gallo, MD, director of the of the IHV, William Blattner, MD, retired since 2016 and formerly associate director of the IHV and director of IHV’s Division of Epidemiology and Prevention and Robert Redfield, MD, resigned in March 2018 to become director of the U.S. Centers for Disease Control and Prevention (CDC) and formerly associate director of the IHV and director of IHV’s Division of Clinical Care and Research. In addition to the two Divisions mentioned, IHV is also comprised of the Infectious Agents and Cancer Division, Vaccine Research Division, Immunotherapy Division, a Center for International Health, Education & Biosecurity, and four Scientific Core Facilities. The Institute, with its various laboratory and patient care facilities, is uniquely housed in a 250,000-square-foot building located in the center of Baltimore and our nation’s HIV/AIDS pandemic. IHV creates an environment where multidisciplinary research, education, and clinical programs work closely together to expedite the scientific understanding of HIV/AIDS pathogenesis and to develop therapeutic interventions to make AIDS and virally-caused cancers manageable, if not curable, diseases. A particular focus of IHV includes learning how to utilize the body’s natural chemistry for its own therapeutic potential and pursuing biologically-based treatment approaches that are less toxic to the body and, often, less costly to the patient and public. IHV also pursues the development of effective therapeutic and preventative vaccines, science’s greatest hope in putting an end to the AIDS pandemic. IHV’s more than 300 employees include more than 80 faculty whose research efforts are focused in the area of chronic human viral infection and disease. At present, more than 75 percent of the Institute’s clinical and research effort is targeted at HIV infection, but also includes SARS-CoV-2, hepatitis C virus, human T cell leukemia viruses 1 and 2, human papillomavirus, herpes viruses and cancer research. IHV’s patient base has grown from just 200 patients to approximately 5,000 in Baltimore and Washington, D.C., and more than 2 million in African and Caribbean nations. In particular, IHV is internationally renowned for its basic science and vaccine research, which includes a preventive HIV vaccine candidate in human clinical trials and funded largely by the Bill & Melinda Gates Foundation. 2 | INSTITUTE OF HUMAN VIROLOGY | ANNUAL REPORT Contents Director’s Message .....................................................................................................................5-10 IHV Leadership .................................................................................................................................. 11 Infectious Agents and Cancer .........................................................................................12-25 Vaccine Research .....................................................................................................................26-29 Clinical Care and Research ................................................................................................30-43 Epidemiology and Prevention ........................................................................................44-55 Immunotherapy .......................................................................................................................56-57 Center for International Health, Education, and Biosecurity (CIHEB) ........................................................................................................58-69 Scientific Core Facilities ........................................................................................................70-75 Global Virus Network (GVN) .............................................................................................76-78 IHV Faculty ....................................................................................................................................79-81 Financial Overview......................................................................................................................... 82 IHV Board Memberships ............................................................................................................ 83 The Institute of Human Virology is the first institute at the University of Maryland School of Medicine and is affiliated with the University of Maryland Medical Center. For more information call Nora Samaranayake at 410.706.8614 or visit www.ihv.org 2020 | 3 Our Mission The Institute of Human Virology (IHV) was established to create and develop a world-class center of excellence focusing on chronic viral diseases, especially HIV/AIDS, and virally-linked cancers. The IHV is dedicated to the discovery, research, treatment, and prevention of these diseases. Its unique structure seeks to connect cohesive, multi-disciplinary research and clinical programs so that new treatments are streamlined from discovery to patient. The IHV serves patients locally and the scientific community globally. 4 | INSTITUTE OF HUMAN VIROLOGY | ANNUAL REPORT Director’s Message A Look at the year The Institute of Human Virology at the University of Maryland School of Medicine flourished this past fiscal year. In October 2019, IHV hosted its 21st Annual International Meeting (IHV2019) at the Four Seasons Hotel in Baltimore. IHV’s Annual International Meeting attracts hundreds of elite scientists who descend upon Baltimore to share ideas and inspire medical virus Robert C. Gallo, MD research collaborations. The meeting program’s organization was led mainly by Shyam Kottilil, MBBS, PhD, Professor of Medicine, Director of the Division of Clinical Care and Research and Head of the Clinical Care Research Unit, Institute of Human Virology, University of Maryland School of Medicine with help from Man Charurat, PhD, Professor of Medicine, Director of the Division of Epidemiology and Prevention and Director, CIHEB, Institute of Human Virology, University of Maryland School of Medicine and Anthony Amoroso, MD, Associate Professor of Medicine, Associate Director of the Division of Clinical Care and Research and Head of Clinical Care Programs, Institute of Human Virology, University of Maryland School of Medicine. This year, the Institute’s faculty voted to focus on one theme, “Progress in HIV/AIDS: Challenges in 2020” which opened with highlights about the recent plan for “Ending the HIV Epidemic by 2030” with expert opinions by Anthony Fauci, MD, Director, National Institute of Allergy and Infectious Diseases (NIAID), Nora Volkow, MD, Director, National Institute of Drug Abuse (NIDA) and ADM Brett P. Giroir, MD, Assistant Secretary for Health at the U.S. Department of Health and Human Services (HHS), among other notable speakers throughout the two day meeting. Welcome remarks were also provided by Maryland Senate President Bill Ferguson and Maryland Delegate Brooke Lierman. The Meeting, which attracts hundreds of elite scientists who descend upon Baltimore to share ideas and inspire medical virus research collaborations, focused on two critical issues including leveraging scientific advances in the field of HIV to end the HIV epidemic in America and integrating resources to address the ongoing opioid epidemic and prevent its impact on the lives of Anthony Fauci, MD HIV infected patients. 2020 | 5 The first day of the meeting focused on a February 2019 initiative announced between multiple agencies within the federal government to address the HIV epidemic, setting the goal of a 90 percent reduction in HIV incident by 2029. The “Ending the HIV Epidemic” pathway is based in four pillars: (1) Diagnose, with an emphasis on early detection; (2) Treat, initiating ART rapidly; (3) Protect, utilizing prevention strategies such as PrEP; and (4) Respond, detecting new HIV clusters. The initial phase of the initiative targeted 48 counties that serve as hotspots of new infection across the U.S. Despite progress in reducing incident HIV in the U.S., L to R: Robert Gallo, MD and Dean E. Albert Reece, MD, PhD, MBA, there remains a disproportionate rise among marginalized Executive Vice President for Medical Affairs, University of Maryland, and the John Z. and Akiko K. Bowers Distinguished Professor and populations including black and Latino male-to-male sex (MSM), Dean at the University of Maryland School of Medicine persons who inject drugs (PWID), black female heterosexuals, and transgender individuals, and a concentration of these new cases in the South. As such, there is a renewed interest in evidence-based prevention strategies to target these populations, many of whom remain out of medical care. Prevention strategies including sexual education, condoms, syringe exchange, and pre-exposure prophylaxis were reviewed, along with challenges and possibilities
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