Polyclonal Antibody to Olfactory Receptor 2J3 (C-Term) - Aff - Purified

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Polyclonal Antibody to Olfactory Receptor 2J3 (C-Term) - Aff - Purified

OriGene Technologies, Inc. OriGene Technologies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected] AP53031PU-N Polyclonal Antibody to Olfactory receptor 2J3 (C-term) - Aff - Purified Alternate names: Hs6M1-3, OR2J3, Olfactory receptor OR6-16 Quantity: 0.4 ml Concentration: lot specific Background: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. Uniprot ID: O76001 NCBI: NP_001005216 GeneID: 442186 Host / Isotype: Rabbit / Ig Immunogen: KLH conjugated synthetic peptide between 254-283 amino acids from the C-terminal region of Human Olfactory receptor 2J3 Genename: OR2J3 Format: State: Liquid purified Ig fraction Purification: Protein A column, followed by peptide affinity purification Buffer System: PBS containing 0.09% (W/V) Sodium Azide as preservative Applications: ELISA: 1/1000. Western Blot: 1/100-1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: This antibody recognizes Human Olfactory receptor 2J3 (C-term). Add. Information: Molecular Weight: 34950 Da Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. General Readings: Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) Menashe, I., et al. BMC Bioinformatics 7, 393 (2006) Malnic, B., et al. Proc. Natl. Acad. Sci. U.S.A. 101(8):2584-2589(2004) Fuchs, T., et al. Genomics 80(3):295-302(2002) Glusman, G., et al. Genome Res. 11(5):685-702(2001) For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130815 1 / 2 AP53031PU-N: Polyclonal Antibody to Olfactory receptor 2J3 (C-term) - Aff - Purified Pictures: Western blot analysis of OR2J3 Antibody (C-term) Pab Cat.-No AP53031PU-N pre- incubated without (Lane 1) and with (Lane 2) blocking peptide in mouse placenta tissue lysate. OR2J3 Antibody (C- term) (arrow) was detected using the purified Pab (1:60/250 dilution). For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130815 2 / 2 Powered by TCPDF (www.tcpdf.org).

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Genetic Variation Across the Human Olfactory Receptor Repertoire Alters Odor Perception
bioRxiv preprint doi: https://doi.org/10.1101/212431; this version posted November 1, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Genetic variation across the human olfactory receptor repertoire alters odor perception Casey Trimmer1,*, Andreas Keller2, Nicolle R. Murphy1, Lindsey L. Snyder1, Jason R. Willer3, Maira Nagai4,5, Nicholas Katsanis3, Leslie B. Vosshall2,6,7, Hiroaki Matsunami4,8, and Joel D. Mainland1,9 1Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA 2Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York, USA 3Center for Human Disease Modeling, Duke University Medical Center, Durham, North Carolina, USA 4Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA 5Department of Biochemistry, University of Sao Paulo, Sao Paulo, Brazil 6Howard Hughes Medical Institute, New York, New York, USA 7Kavli Neural Systems Institute, New York, New York, USA 8Department of Neurobiology and Duke Institute for Brain Sciences, Duke University Medical Center, Durham, North Carolina, USA 9Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA *[email protected] ABSTRACT The human olfactory receptor repertoire is characterized by an abundance of genetic variation that affects receptor response, but the perceptual effects of this variation are unclear. To address this issue, we sequenced the OR repertoire in 332 individuals and examined the relationship between genetic variation and 276 olfactory phenotypes, including the perceived intensity and pleasantness of 68 odorants at two concentrations, detection thresholds of three odorants, and general olfactory acuity.
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Supplementary Tables Supplementary Table S1: Clinicopathologic characteristics of 64 patients with untreated primary myxofibrosarcoma Characteristic n (%) or median (range) Gender Male 23 (36%) Female 41 (64%) Age, years 63.5 (24-88) Location Extremity 55 (86%) Trunk/chest wall 8 (13%) Retroperitoneal 1 (1%) Size, cm ≤5 9 (14%) >5; ≤10 34 (53%) >10 21 (33%) Median 8.5 (3.1-25) Depth Superficial 12 (19%) Deep 52 (81%) Surgical margins R0 49 (77%) R1 15 (23%) Percent Myxoid 75% (10%-100%) Local Recurrence 14 (22%) Distant Recurrence 22 (34%) Died of Disease 17 (27%) Follow-up, years All patients 2.6 (0.1-9.2) Surviving patients 3.1 (0.4-9.2) Time to death, years 1.8 (0.7-3.3) 213338 at RIS1 3.00E-06 -2.45 219840 s at TCL6 1.30E-05 -0.25 201645 at TNC 2.00E-06 -2.15 208052 x at CEACAM3 1.40E-05 -0.25 205542 at STEAP1 1.70E-05 -1.74 210339 s at KLK2 1.40E-05 -0.25 212473 s at MICAL2 2.20E-05 -1.6 206612 at CACNG1 1.50E-05 -0.25 204337 at RGS4 <1.00E-06 -1.51 205531 s at GLS2 1.60E-05 -0.25 208025 s at HMGA2 4.50E-05 -1.51 215274 at SLC12A3 1.60E-05 -0.25 204464 s at EDNRA 6.00E-05 -1.48 216881 x at PRB4 1.60E-05 -0.25 208712 at CCND1 1.20E-05 -1.47 206869 at CHAD 1.80E-05 -0.25 201506 at TGFBI <1.00E-06 -1.32 207528 s at SLC7A11 1.80E-05 -0.25 203324 s at CAV2 <1.00E-06 -1.29 210577 at CASR 1.80E-05 -0.25 201617 x at CALD1 5.00E-06 -1.24 205815 at REG3A 1.90E-05 -0.25 206766 at ITGA10 2.60E-05 -1.23 208204 s at CAV3 1.90E-05 -0.25 209218 at SQLE <1.00E-06 -1.18 220581 at C6orf97 2.00E-05 -0.25 221773 at ELK3 <1.00E-06 -1.14 207007 at NR1I3
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