Supplementary Tables

Supplementary Table S1: Clinicopathologic characteristics of 64 patients with untreated primary myxofibrosarcoma

Characteristic n (%) or median (range) Gender Male 23 (36%) Female 41 (64%) Age, years 63.5 (24-88) Location Extremity 55 (86%) Trunk/chest wall 8 (13%) Retroperitoneal 1 (1%) Size, cm ≤5 9 (14%) >5; ≤10 34 (53%) >10 21 (33%) Median 8.5 (3.1-25) Depth Superficial 12 (19%) Deep 52 (81%) Surgical margins R0 49 (77%) R1 15 (23%) Percent Myxoid 75% (10%-100%) Local Recurrence 14 (22%) Distant Recurrence 22 (34%) Died of Disease 17 (27%) Follow-up, years All patients 2.6 (0.1-9.2) Surviving patients 3.1 (0.4-9.2) Time to death, years 1.8 (0.7-3.3)

213338 at RIS1 3.00E-06 -2.45 219840 s at TCL6 1.30E-05 -0.25 201645 at TNC 2.00E-06 -2.15 208052 x at CEACAM3 1.40E-05 -0.25 205542 at STEAP1 1.70E-05 -1.74 210339 s at KLK2 1.40E-05 -0.25 212473 s at MICAL2 2.20E-05 -1.6 206612 at CACNG1 1.50E-05 -0.25 204337 at RGS4 <1.00E-06 -1.51 205531 s at GLS2 1.60E-05 -0.25 208025 s at HMGA2 4.50E-05 -1.51 215274 at SLC12A3 1.60E-05 -0.25 204464 s at EDNRA 6.00E-05 -1.48 216881 x at PRB4 1.60E-05 -0.25 208712 at CCND1 1.20E-05 -1.47 206869 at CHAD 1.80E-05 -0.25 201506 at TGFBI <1.00E-06 -1.32 207528 s at SLC7A11 1.80E-05 -0.25 203324 s at CAV2 <1.00E-06 -1.29 210577 at CASR 1.80E-05 -0.25 201617 x at CALD1 5.00E-06 -1.24 205815 at REG3A 1.90E-05 -0.25 206766 at ITGA10 2.60E-05 -1.23 208204 s at CAV3 1.90E-05 -0.25 209218 at SQLE <1.00E-06 -1.18 220581 at C6orf97 2.00E-05 -0.25 221773 at ELK3 <1.00E-06 -1.14 207007 at NR1I3 2.10E-05 -0.25 219926 at POPDC3 <1.00E-06 -1.14 208234 x at FGFR2 2.20E-05 -0.25 204017 at KDELR3 1.00E-05 -1.12 216600 x at ALDOB 2.50E-05 -0.25 209890 at TSPAN5 1.00E-05 -1.1 206812 at ADRB3 2.60E-05 -0.25 210845 s at PLAUR 9.00E-06 -1.07 207862 at UPK2 2.60E-05 -0.25 218424 s at STEAP3 9.00E-06 -1.07 204532 x at UGT1A10 2.70E-05 -0.25 212771 at C10orf38 6.00E-06 -1.05 211117 x at ESR2 2.70E-05 -0.25 221502 at KPNA3 <1.00E-06 -1.03 211689 s at TMPRSS2 2.70E-05 -0.25 207265 s at KDELR3 1.20E-05 -1.03 205840 x at GH1 2.90E-05 -0.25 212449 s at LYPLA1 <1.00E-06 -1 216128 at TBCD 2.90E-05 -0.25 218984 at FLJ20485 <1.00E-06 -0.99 220958 at ULK4 3.00E-05 -0.25 211924 s at PLAUR 2.30E-05 -0.99 221329 at OR52A1 3.00E-05 -0.25 202304 at FNDC3A <1.00E-06 -0.93 210641 at CAPN9 3.10E-05 -0.25 201300 s at PRNP 7.40E-05 -0.93 221456 at TAS2R3 3.20E-05 -0.25 221503 s at KPNA3 <1.00E-06 -0.9 31861 at IGHMBP2 3.20E-05 -0.25 208691 at TFRC 4.10E-05 -0.89 217017 at OSBPL10 3.50E-05 -0.25 201324 at EMP1 1.70E-05 -0.87 221184 at — 3.90E-05 -0.25 203323 at CAV2 9.70E-05 -0.87 204763 s at GNAO1 4.00E-05 -0.25 201063 at RCN1 4.00E-06 -0.86 216116 at — 4.30E-05 -0.25 220147 s at FAM60A 2.70E-05 -0.85 208139 s at — 4.90E-05 -0.25 214039 s at LAPTM4B 1.20E-05 -0.84 220902 at FLJ12616 4.90E-05 -0.25 204967 at APXL <1.00E-06 -0.83 215865 at SYT12 5.60E-05 -0.25 212887 at SEC23A 2.10E-05 -0.83 201974 s at C7orf28A 5.80E-05 -0.25 209286 at CDC42EP3 5.80E-05 -0.82 206630 at TYR 5.80E-05 -0.25 203999 at SYT1 3.90E-05 -0.81 218623 at HMP19 6.10E-05 -0.25 206805 at SEMA3A 8.00E-06 -0.8 220819 at FRMD1 6.10E-05 -0.25 204339 s at RGS4 <1.00E-06 -0.76 206679 at APBA1 6.20E-05 -0.25 202710 at BET1 1.10E-05 -0.76 207220 at DO 6.50E-05 -0.25 205453 at HOXB2 1.10E-05 -0.76 214088 s at FUT3 6.70E-05 -0.25 205199 at CA9 1.40E-05 -0.76 217134 at MTAP 7.30E-05 -0.25 212077 at CALD1 1.80E-05 -0.76 200724 at RPL10 7.50E-05 -0.25 204338 s at RGS4 8.30E-05 -0.76 207385 at TFDP3 7.60E-05 -0.25 204693 at CDC42EP1 <1.00E-06 -0.74 214956 at — 7.90E-05 -0.25 206713 at NTNG1 <1.00E-06 -0.73 216152 at PDZRN3 7.90E-05 -0.25 207431 s at DEGS1 <1.00E-06 -0.72 210744 s at IL5RA 8.70E-05 -0.25 219888 at SPAG4 2.00E-05 -0.72 217568 at FAM12A 8.70E-05 -0.25 205677 s at DLEU1 <1.00E-06 -0.71 206755 at CYP2B6 9.80E-05 -0.25 218796 at C20orf42 <1.00E-06 -0.7 217181 at — <1.00E-06 -0.24 216348 at RPS17* 2.00E-06 -0.7 220805 at HRH2 <1.00E-06 -0.24 212149 at KIAA0143 3.00E-06 -0.7 206930 at GLYAT <1.00E-06 -0.24 201921 at GNG10* 8.00E-06 -0.7 208311 at GPR50 <1.00E-06 -0.24 213102 at ACTR3 1.20E-05 -0.69 216085 at DKFZP434C153 <1.00E-06 -0.24 396 f at EPOR <1.00E-06 -0.68 201766 at ELAC2 2.00E-06 -0.24 200994 at IPO7 3.90E-05 -0.68 215829 at SHANK2 2.00E-06 -0.24 220603 s at MCTP2 3.00E-06 -0.67 217630 at ANGEL2 2.00E-06 -0.24 217975 at WBP5 1.40E-05 -0.67 220366 at ELSPBP1 2.00E-06 -0.24 221266 s at TM7SF4 <1.00E-06 -0.66 206290 s at RGS7 3.00E-06 -0.24 218516 s at IMPAD1 8.00E-06 -0.66 207368 at HTR1D 3.00E-06 -0.24 204575 s at MMP19 6.80E-05 -0.66 220732 at DEPDC2 3.00E-06 -0.24 218566 s at CHORDC1 <1.00E-06 -0.65 221459 at TAAR5 3.00E-06 -0.24 203438 at STC2 6.00E-06 -0.65 221644 s at SLC45A2 3.00E-06 -0.24 Myxoﬁbrosarcoma 2

217266 at RPL15 1.80E-05 -0.65 208448 x at IFNA16 5.00E-06 -0.24 220167 s at TP53TG3 1.80E-05 -0.65 215003 at DGCR9 5.00E-06 -0.24 200639 s at YWHAZ <1.00E-06 -0.64 211786 at TNFRSF9 6.00E-06 -0.24 204729 s at STX1A <1.00E-06 -0.63 217619 x at — 7.00E-06 -0.24 214866 at PLAUR 3.00E-06 -0.63 220829 s at B3GALT1 9.00E-06 -0.24 205975 s at HOXD1 <1.00E-06 -0.62 206094 x at UGT1A6 1.10E-05 -0.24 216849 at FLJ16124 <1.00E-06 -0.62 91826 at EPS8L1 1.10E-05 -0.24 211936 at HSPA5 2.00E-06 -0.62 219943 s at FLJ11850 1.20E-05 -0.24 203119 at MGC2574 6.00E-06 -0.62 220930 s at MGC5590 1.20E-05 -0.24 218113 at TMEM2 1.20E-05 -0.62 216690 at OR7C1 1.30E-05 -0.24 221753 at SSH1 1.20E-05 -0.62 220886 at GABRQ 1.30E-05 -0.24 71933 at WNT6 <1.00E-06 -0.61 207214 at SPINK4 1.50E-05 -0.24 215479 at SEMA6A <1.00E-06 -0.61 208597 at CNTF 1.50E-05 -0.24 208161 s at ABCC3 6.00E-06 -0.61 215419 at KIAA1086 1.50E-05 -0.24 213100 at UNC5B 2.30E-05 -0.61 208507 at OR7C2 1.60E-05 -0.24 201358 s at COPB <1.00E-06 -0.6 216219 at AQP6 1.90E-05 -0.24 213577 at SQLE <1.00E-06 -0.6 219887 at FLJ10786 1.90E-05 -0.24 221347 at CHRM5 <1.00E-06 -0.6 220993 s at GPR63 1.90E-05 -0.24 206429 at F2RL1 3.90E-05 -0.6 220537 at MTMR8 2.10E-05 -0.24 219634 at CHST11 9.30E-05 -0.6 207951 at CSN2 2.30E-05 -0.24 209294 x at TNFRSF10B <1.00E-06 -0.59 216709 at — 2.30E-05 -0.24 220428 at CD207 <1.00E-06 -0.59 221429 x at TEX13A 2.30E-05 -0.24 209250 at DEGS1 2.00E-06 -0.59 215890 at GM2A 2.40E-05 -0.24 211452 x at LRRFIP1 1.40E-05 -0.59 216790 at — 2.70E-05 -0.24 217599 s at MDFIC 5.80E-05 -0.59 211384 s at CASR 2.80E-05 -0.24 221580 s at MGC5306 9.20E-05 -0.59 205845 at CACNA1H 3.10E-05 -0.24 200921 s at BTG1 9.90E-05 -0.59 216907 x at KIR3DL2 3.50E-05 -0.24 208203 x at KIR2DS5 <1.00E-06 -0.58 208062 s at NRG2 3.60E-05 -0.24 218644 at PLEK2 <1.00E-06 -0.58 216636 at — 3.80E-05 -0.24 219735 s at TFCP2L1 <1.00E-06 -0.58 205093 at PLEKHA6 4.00E-05 -0.24 211708 s at SCD 6.00E-06 -0.58 221285 at ST8SIA2 4.10E-05 -0.24 221330 at CHRM2 8.00E-06 -0.58 207421 at CA5A 4.20E-05 -0.24 214265 at ITGA8 1.60E-05 -0.58 211157 at — 4.30E-05 -0.24 201260 s at SYPL1 5.30E-05 -0.58 221035 s at TEX14 4.60E-05 -0.24 202488 s at FXYD3 <1.00E-06 -0.57 216986 s at IRF4 5.00E-05 -0.24 208520 at OR10H3 <1.00E-06 -0.57 208439 s at FCN2 5.10E-05 -0.24 210270 at RGS6 <1.00E-06 -0.57 214905 at LOC145899 5.10E-05 -0.24 219557 s at NRIP3 <1.00E-06 -0.57 208364 at INPP4A 5.20E-05 -0.24 205793 x at TNK1 <1.00E-06 -0.56 205772 s at AKAP7 5.50E-05 -0.24 216757 at GALNT7 <1.00E-06 -0.56 221422 s at C9orf45 5.70E-05 -0.24 217170 at — <1.00E-06 -0.56 206678 at GABRA1 6.10E-05 -0.24 206614 at GDF5 <1.00E-06 -0.56 91682 at EXOSC4 6.20E-05 -0.24 211945 s at ITGB1 5.00E-06 -0.56 211544 s at GHRHR 6.70E-05 -0.24 202211 at ARFGAP3 1.90E-05 -0.56 216079 at EPM2A 6.80E-05 -0.24 212245 at MCFD2 5.90E-05 -0.56 207874 s at CFHL4* 7.00E-05 -0.24 214805 at EIF4A1 6.00E-05 -0.56 216696 s at PRODH2 7.80E-05 -0.24 212364 at MYO1B 8.70E-05 -0.56 207698 at C6orf123 8.00E-05 -0.24 205832 at CPA4 <1.00E-06 -0.55 215824 at NUDT7 8.10E-05 -0.24 206186 at MPP3 <1.00E-06 -0.55 205064 at SPRR1B 8.30E-05 -0.24 211153 s at TNFSF11 <1.00E-06 -0.55 220282 at RIC3 8.40E-05 -0.24 215511 at TCF20 <1.00E-06 -0.55 220622 at LRRC31 8.80E-05 -0.24 211405 x at IFNA17 2.00E-06 -0.55 1494 f at CYP2A6 8.90E-05 -0.24 221112 at IL1RAPL2 2.00E-06 -0.55 207074 s at SLC18A1 8.90E-05 -0.24 219215 s at SLC39A4 1.90E-05 -0.55 204673 at MUC2 9.10E-05 -0.24 205031 at EFNB3 5.20E-05 -0.55 217008 s at GRM7 9.30E-05 -0.24 204411 at KIF21B <1.00E-06 -0.54 208593 x at CRHR1 9.50E-05 -0.24 217307 at — <1.00E-06 -0.54 220048 at EDAR 9.80E-05 -0.24 221114 at AMBN <1.00E-06 -0.54 216249 at PVT1 <1.00E-06 -0.23 202597 at IRF6 <1.00E-06 -0.54 207151 at ADCYAP1R1 <1.00E-06 -0.23 208378 x at FGF5 1.30E-05 -0.54 211214 s at DAPK1 <1.00E-06 -0.23 205137 x at USH1C <1.00E-06 -0.53 38707 r at E2F4 <1.00E-06 -0.23 211497 x at NKX3-1 <1.00E-06 -0.53 207770 x at CSH2 2.00E-06 -0.23 221313 at GPR52 <1.00E-06 -0.53 206199 at CEACAM7 4.00E-06 -0.23 205676 at CYP27B1 2.00E-06 -0.53 221395 at TAS2R13 6.00E-06 -0.23 214357 at C1orf105 2.00E-06 -0.53 211830 s at CACNA1I 7.00E-06 -0.23 211241 at ANXA2P3 1.60E-05 -0.53 211238 at ADAM7 9.00E-06 -0.23 200738 s at PGK1 1.70E-05 -0.53 216536 at OR7E19P 9.00E-06 -0.23 215823 x at PABPC3 2.20E-05 -0.53 206014 at ACTL6B 1.00E-05 -0.23 214053 at ERBB4 3.30E-05 -0.53 220192 x at SPDEF 1.00E-05 -0.23 209060 x at NCOA3 6.60E-05 -0.53 207751 at — 1.20E-05 -0.23 205402 x at PRSS2 <1.00E-06 -0.52 222373 at CIP29 1.30E-05 -0.23 207082 at CSF1 <1.00E-06 -0.52 216989 at SPAM1 1.50E-05 -0.23 208285 at OR7A5 <1.00E-06 -0.52 207227 x at RFPL2 1.60E-05 -0.23 210357 s at SMOX <1.00E-06 -0.52 220262 s at EGFL9 1.70E-05 -0.23 221090 s at FLJ10826 <1.00E-06 -0.52 220264 s at GPR107 1.70E-05 -0.23 Myxoﬁbrosarcoma 3

207718 x at CYP2A6 <1.00E-06 -0.52 210614 at TTPA 2.20E-05 -0.23 211410 x at KIR2DL5A <1.00E-06 -0.52 221066 at RLN3R1 2.50E-05 -0.23 210124 x at SEMA4F 2.50E-05 -0.52 214341 at AP1G2 2.90E-05 -0.23 208736 at ARPC3 2.60E-05 -0.52 206947 at B3GALT5 3.00E-05 -0.23 202722 s at GFPT1 2.70E-05 -0.52 221001 at X102 3.40E-05 -0.23 215574 at — 3.20E-05 -0.52 215244 at DGCR5 3.70E-05 -0.23 203390 s at KIF3C <1.00E-06 -0.51 217305 s at SAC 3.70E-05 -0.23 206127 at ELK3 <1.00E-06 -0.51 204397 at EML2 4.20E-05 -0.23 217240 at SIRPB1 <1.00E-06 -0.51 211402 x at NR6A1 4.20E-05 -0.23 218812 s at C7orf19 <1.00E-06 -0.51 211151 x at GH1 4.30E-05 -0.23 221173 at USH1C <1.00E-06 -0.51 214233 at GGA2 4.30E-05 -0.23 221324 at TAS2R1 <1.00E-06 -0.51 221134 at ANGPT4 4.30E-05 -0.23 41856 at UNC5B <1.00E-06 -0.51 206768 at RPL3L 4.60E-05 -0.23 210393 at LGR5 2.00E-06 -0.51 208008 at DKFZP434O047 4.70E-05 -0.23 213085 s at KIBRA 1.00E-05 -0.51 207577 at HTR4 4.80E-05 -0.23 208113 x at PABPC3 2.90E-05 -0.51 211848 s at CEACAM7 4.80E-05 -0.23 221107 at CHRNA9 4.70E-05 -0.51 207995 s at CLEC4M 5.00E-05 -0.23 205067 at IL1B 1.00E-04 -0.51 215327 at — 5.30E-05 -0.23 207929 at GRPR <1.00E-06 -0.5 221337 s at ADAM29 5.40E-05 -0.23 207960 at — <1.00E-06 -0.5 48612 at N4BP1 5.50E-05 -0.23 208241 at NRG1 <1.00E-06 -0.5 206137 at RIMS2 6.00E-05 -0.23 208384 s at MID2 <1.00E-06 -0.5 215395 x at TRY6 6.40E-05 -0.23 210405 x at TNFRSF10B <1.00E-06 -0.5 214758 at WDR21A 6.50E-05 -0.23 220815 at CTNNA3 <1.00E-06 -0.5 217169 at IGHG3* 6.60E-05 -0.23 217149 x at TNK1 <1.00E-06 -0.5 207642 at HCRT 7.00E-05 -0.23 207878 at KRT2B 2.00E-06 -0.5 214921 at KCNMA1 7.00E-05 -0.23 214427 at NOL1 5.00E-06 -0.5 207658 s at FOXG1B* 7.20E-05 -0.23 211203 s at CNTN1 7.00E-06 -0.5 221623 at BCAN 7.20E-05 -0.23 219463 at C20orf103 2.10E-05 -0.5 205650 s at FGA 8.80E-05 -0.23 211599 x at MET 2.30E-05 -0.5 220291 at GDPD2 8.90E-05 -0.23 214315 x at CALR 2.80E-05 -0.5 219934 s at SULT1E1 9.00E-05 -0.23 206226 at HRG <1.00E-06 -0.49 206926 s at IL11 9.50E-05 -0.23 216535 at IGSF4B <1.00E-06 -0.49 218963 s at KRT23 9.60E-05 -0.23 216579 at GJB4 <1.00E-06 -0.49 211440 x at CYP3A43 9.90E-05 -0.23 206872 at SLC17A1 <1.00E-06 -0.49 217668 at — 1.00E-04 -0.23 208331 at BPY2 <1.00E-06 -0.49 217139 at VDAC1 <1.00E-06 -0.22 211614 at — <1.00E-06 -0.49 213770 at KSR 3.00E-06 -0.22 221300 at C15orf2 <1.00E-06 -0.49 211393 at ZNF278 4.00E-06 -0.22 214750 at PLAC4 2.00E-06 -0.49 214842 s at ALB 4.00E-06 -0.22 215818 at NUDT7 2.00E-06 -0.49 206436 at MPPED1 5.00E-06 -0.22 222271 at — 2.00E-06 -0.49 216519 s at PROSC 5.00E-06 -0.22 205637 s at SH3GL3 3.00E-06 -0.49 207427 at ACR 6.00E-06 -0.22 211145 x at IFNA21 3.00E-06 -0.49 217387 at CAPN6 1.40E-05 -0.22 221444 at TAS2R16 3.00E-06 -0.49 206840 at AFM 1.60E-05 -0.22 207908 at KRT2A 1.20E-05 -0.49 222300 at CAPZA1 1.60E-05 -0.22 221901 at KIAA1644 8.60E-05 -0.49 213240 s at KRT4 1.90E-05 -0.22 208000 at GML <1.00E-06 -0.48 208036 at OPN1SW 2.00E-05 -0.22 208182 x at IFNA14 <1.00E-06 -0.48 211193 at TP73L 2.00E-05 -0.22 211189 x at CD84 <1.00E-06 -0.48 221400 at MYO3A 2.10E-05 -0.22 220542 s at PLUNC <1.00E-06 -0.48 206379 at EYA3 2.20E-05 -0.22 206225 at ZNF507 <1.00E-06 -0.48 210147 at ART3 2.30E-05 -0.22 215745 at C4orf9 <1.00E-06 -0.48 211516 at IL5RA 2.30E-05 -0.22 208106 x at PSG6 4.00E-06 -0.48 214416 at — 2.40E-05 -0.22 207601 at SULT1B1 6.00E-06 -0.48 217470 at — 2.50E-05 -0.22 205338 s at DCT 1.30E-05 -0.48 217334 at OR2J3 2.60E-05 -0.22 219065 s at C2orf4 3.10E-05 -0.48 34846 at CAMK2B 2.70E-05 -0.22 203102 s at MGAT2 4.20E-05 -0.48 204515 at HSD3B1 3.20E-05 -0.22 203441 s at CDH2 5.80E-05 -0.48 216721 at SLC25A30 3.30E-05 -0.22 202666 s at ACTL6A 9.20E-05 -0.48 216767 at PARVA 3.40E-05 -0.22 218871 x at GALNACT-2 9.50E-05 -0.48 214519 s at RLN2 3.50E-05 -0.22 216698 x at OR7E47P <1.00E-06 -0.47 221307 at KCNIP1 3.50E-05 -0.22 206406 at SMCP <1.00E-06 -0.47 217284 x at SERHL 3.70E-05 -0.22 209948 at KCNMB1 <1.00E-06 -0.47 208260 at AVPR1B 3.80E-05 -0.22 210325 at CD1A <1.00E-06 -0.47 208028 s at GPX5 3.90E-05 -0.22 216922 x at DAZ1 <1.00E-06 -0.47 218054 s at MGC2749 3.90E-05 -0.22 221183 at DKFZP564O0823 <1.00E-06 -0.47 207527 at KCNJ9 4.00E-05 -0.22 205445 at PRL 2.00E-06 -0.47 215689 s at SHBG 4.00E-05 -0.22 210247 at SYN2 2.00E-06 -0.47 206843 at CRYBA4 4.10E-05 -0.22 219010 at C1orf106 3.00E-06 -0.47 220222 at C8orf39 4.20E-05 -0.22 214070 s at ATP10B 4.00E-06 -0.47 206044 s at BRAF 4.30E-05 -0.22 222245 s at FER1L4 4.00E-06 -0.47 210730 s at NPY2R 4.30E-05 -0.22 216351 x at DAZ1 1.00E-05 -0.47 203271 s at UNC119 4.40E-05 -0.22 209247 s at ABCF2 1.10E-05 -0.47 215825 at — 4.70E-05 -0.22 208624 s at EIF4G1 3.50E-05 -0.47 214518 at PDHA2 4.80E-05 -0.22 209740 s at PNPLA4 4.00E-05 -0.47 210452 x at CYP4F2 5.10E-05 -0.22 Myxoﬁbrosarcoma 4

215100 at C6orf105 4.50E-05 -0.47 214610 at CYP11B1 5.40E-05 -0.22 207044 at THRB <1.00E-06 -0.46 211484 s at DSCAM 5.80E-05 -0.22 207260 at FEV <1.00E-06 -0.46 215826 x at BC37295 3 6.30E-05 -0.22 219916 s at RNF39 <1.00E-06 -0.46 207228 at PRKACG 7.00E-05 -0.22 220141 at FLJ23554 <1.00E-06 -0.46 217439 at — 7.10E-05 -0.22 221100 at C6orf15 <1.00E-06 -0.46 215710 at ST3GAL4 7.40E-05 -0.22 222304 x at OR7E47P <1.00E-06 -0.46 216618 at — 7.80E-05 -0.22 222340 at — <1.00E-06 -0.46 221624 at TCL6 7.80E-05 -0.22 209635 at AP1S1 <1.00E-06 -0.46 220780 at PLA2G3 8.00E-05 -0.22 216292 at PTPRM 2.00E-06 -0.46 221160 s at CABP3* 8.40E-05 -0.22 221393 at TAAR3 2.00E-06 -0.46 208360 s at — 9.00E-05 -0.22 216692 at ZNF337 3.00E-06 -0.46 217490 at — 9.30E-05 -0.22 211190 x at CD84 1.40E-05 -0.46 202712 s at CKMT1B* 9.40E-05 -0.22 216738 at HRH1 1.50E-05 -0.46 206419 at RORC 9.50E-05 -0.22 219877 at ZMAT4 1.50E-05 -0.46 207933 at ZP2 9.90E-05 -0.22 209844 at HOXB13 2.90E-05 -0.46 205630 at CRH <1.00E-06 -0.21 217711 at TEK 2.90E-05 -0.46 206895 at PPP1R3A <1.00E-06 -0.21 203074 at ANXA8 <1.00E-06 -0.45 221364 at GRID2 <1.00E-06 -0.21 206310 at SPINK2 <1.00E-06 -0.45 215851 at EVI1 <1.00E-06 -0.21 207143 at CDK6 <1.00E-06 -0.45 40359 at RASSF7 <1.00E-06 -0.21 208568 at MC2R <1.00E-06 -0.45 205949 at CA1 4.00E-06 -0.21 210523 at BMPR1B <1.00E-06 -0.45 207269 at DEFA4 4.00E-06 -0.21 211397 x at KIR2DL2 <1.00E-06 -0.45 219476 at C1orf116 5.00E-06 -0.21 214539 at SERPINB10 <1.00E-06 -0.45 205982 x at SFTPC 7.00E-06 -0.21 217051 s at SS18 <1.00E-06 -0.45 220196 at MUC16 7.00E-06 -0.21 220214 at ZNF215 <1.00E-06 -0.45 221202 at — 7.00E-06 -0.21 204419 x at HBG1* <1.00E-06 -0.45 209618 at CTNND2 8.00E-06 -0.21 208376 at CCR4 <1.00E-06 -0.45 220767 at — 9.00E-06 -0.21 212925 at C19orf21 <1.00E-06 -0.45 220851 at — 9.00E-06 -0.21 214713 at YLPM1 <1.00E-06 -0.45 207322 at ITSN1 1.00E-05 -0.21 217359 s at NCAM1 <1.00E-06 -0.45 214278 s at NDRG2 1.10E-05 -0.21 220395 at DNAJA4 <1.00E-06 -0.45 215872 at — 1.10E-05 -0.21 208037 s at MADCAM1 2.00E-06 -0.45 209660 at TTR 1.20E-05 -0.21 213680 at KRT6B 2.00E-06 -0.45 202525 at PRSS8 1.30E-05 -0.21 216761 at PDCD8 2.00E-06 -0.45 221053 s at TDRKH 1.30E-05 -0.21 216932 at — 6.00E-06 -0.45 205780 at BIK 1.40E-05 -0.21 220379 at FSCN3 1.40E-05 -0.45 221305 s at UGT1A8* 1.40E-05 -0.21 209641 s at ABCC3 1.80E-05 -0.45 208341 x at CSH2 1.60E-05 -0.21 221794 at DOCK6 2.40E-05 -0.45 220001 at PADI4 2.00E-05 -0.21 216604 s at SLC7A8 3.10E-05 -0.45 217296 at KIR2DS1 2.10E-05 -0.21 205513 at TCN1 4.70E-05 -0.45 214763 at ACOT11 2.40E-05 -0.21 206215 at OPCML 4.70E-05 -0.45 205311 at DDC 2.50E-05 -0.21 220701 at — 4.70E-05 -0.45 215801 at — 2.50E-05 -0.21 210301 at XDH 5.30E-05 -0.45 216564 at LOC402295* 2.90E-05 -0.21 205268 s at ADD2 5.60E-05 -0.45 207095 at SLC10A2 3.40E-05 -0.21 210414 at FLRT1 6.20E-05 -0.45 216780 at — 3.90E-05 -0.21 209186 at ATP2A2 7.20E-05 -0.45 207906 at IL3 4.60E-05 -0.21 206798 x at DLEC1 <1.00E-06 -0.44 210020 x at CALML3 4.80E-05 -0.21 208259 x at IFNA7 <1.00E-06 -0.44 210704 at FEZ2 4.80E-05 -0.21 210412 at GRIN2B <1.00E-06 -0.44 217522 at KCNV2 4.90E-05 -0.21 215161 at CAMK1G <1.00E-06 -0.44 220228 at AP4E1 5.50E-05 -0.21 216676 x at KIR3DL3 <1.00E-06 -0.44 207473 at MLN 5.60E-05 -0.21 217269 s at PRSS7 <1.00E-06 -0.44 222005 s at GNG3 5.80E-05 -0.21 217998 at PHLDA1 <1.00E-06 -0.44 216939 s at HTR4 6.00E-05 -0.21 33579 i at GALR3 <1.00E-06 -0.44 222188 at C9orf156 6.20E-05 -0.21 205103 at C1orf61 <1.00E-06 -0.44 220566 at PIK3R5 7.20E-05 -0.21 207524 at ST7 <1.00E-06 -0.44 205753 at CRP 7.90E-05 -0.21 210883 x at EFNB3 <1.00E-06 -0.44 216172 at EXOSC2 8.10E-05 -0.21 211465 x at FUT6 <1.00E-06 -0.44 215503 at — 8.90E-05 -0.21 211532 x at KIR2DS2 <1.00E-06 -0.44 216285 at DGCR14 9.20E-05 -0.21 217331 at SCC-112 <1.00E-06 -0.44 216275 at BUB1 9.30E-05 -0.21 220737 at RPS6KA6 <1.00E-06 -0.44 208531 at SERPINA2 9.50E-05 -0.21 211446 at RGSL2 2.00E-06 -0.44 220680 at RAVER2 3.00E-06 -0.2 214558 at GPR12 2.00E-06 -0.44 214381 at LOC441601 4.00E-06 -0.2 220881 at LMO2 2.00E-06 -0.44 205703 at ATP6V0A2 5.00E-06 -0.2 208035 at GRM6 3.00E-06 -0.44 215958 at RAB5A 5.00E-06 -0.2 204987 at ITIH2 5.00E-06 -0.44 217003 s at ADAM5 5.00E-06 -0.2 207366 at KCNS1 7.00E-06 -0.44 206946 at HCN4 9.00E-06 -0.2 222296 at — 1.00E-05 -0.44 216029 at — 9.00E-06 -0.2 218653 at SLC25A15 2.80E-05 -0.44 206079 at CHML 1.10E-05 -0.2 217776 at RDH11 5.10E-05 -0.44 215601 at STARD7 1.30E-05 -0.2 208844 at VDAC3 5.80E-05 -0.44 211388 s at — 1.40E-05 -0.2 221648 s at C1orf121 7.00E-05 -0.44 215914 at — 1.70E-05 -0.2 220450 at — 7.90E-05 -0.44 215413 at EXOC7 2.00E-05 -0.2 210890 x at KIR2DL1 <1.00E-06 -0.43 211816 x at FCAR 2.40E-05 -0.2 Myxoﬁbrosarcoma 5

217030 at UNC5D <1.00E-06 -0.43 208135 at TCF2 2.50E-05 -0.2 220853 at GTDC1 <1.00E-06 -0.43 206549 at INSL4 2.90E-05 -0.2 220867 s at SLC24A2 <1.00E-06 -0.43 211885 x at FUT6 2.90E-05 -0.2 207330 at PZP <1.00E-06 -0.43 65517 at AP1M2 3.00E-05 -0.2 207400 at NPY5R <1.00E-06 -0.43 208427 s at ELAVL2 3.30E-05 -0.2 207880 at ADAM11 <1.00E-06 -0.43 216096 s at NRXN1 3.80E-05 -0.2 208198 x at KIR2DS1 <1.00E-06 -0.43 217065 at — 3.80E-05 -0.2 211893 x at CD6 <1.00E-06 -0.43 207158 at APOBEC1 3.90E-05 -0.2 220421 at BTNL8 <1.00E-06 -0.43 207445 s at CCR9 3.90E-05 -0.2 204762 s at GNAO1 2.00E-06 -0.43 216934 at — 3.90E-05 -0.2 205920 at SLC6A6 2.00E-06 -0.43 208603 s at MAPK8IP2 4.40E-05 -0.2 207936 x at RFPL3 2.00E-06 -0.43 214065 s at CIB2 4.40E-05 -0.2 216678 at WDR10 2.00E-06 -0.43 217026 at CFTR 4.40E-05 -0.2 219232 s at EGLN3 4.00E-06 -0.43 214407 x at GYPB 4.90E-05 -0.2 204091 at PDE6D 7.00E-06 -0.43 217045 x at NCR2 5.20E-05 -0.2 215065 at PHF8 1.40E-05 -0.43 211836 s at MOG 5.70E-05 -0.2 218865 at MOSC1 1.40E-05 -0.43 207523 at C6orf10 6.00E-05 -0.2 222044 at C20orf67 2.70E-05 -0.43 213950 s at PPP3CC 6.20E-05 -0.2 216547 at LOC127406 6.20E-05 -0.43 216864 at — 6.80E-05 -0.2 217211 at — 6.30E-05 -0.43 206149 at LOC63928 7.10E-05 -0.2 206745 at HOXC11 8.10E-05 -0.43 219776 s at FLJ11125 7.30E-05 -0.2 204437 s at FOLR1 <1.00E-06 -0.42 221140 s at GPR132 7.40E-05 -0.2 206191 at ENTPD3 <1.00E-06 -0.42 216186 at C1orf20 7.50E-05 -0.2 208344 x at IFNA13 <1.00E-06 -0.42 219638 at FBXO22 7.50E-05 -0.2 214340 at ALOX12P2 <1.00E-06 -0.42 211204 at ME1 8.00E-05 -0.2 220158 at LGALS14 <1.00E-06 -0.42 220883 at — 9.00E-05 -0.2 208013 s at ACRV1 <1.00E-06 -0.42 204965 at GC 9.50E-05 -0.2 210399 x at FUT6 <1.00E-06 -0.42 217409 at MYO5A 9.50E-05 -0.2 217029 at BAX <1.00E-06 -0.42 210760 x at TRIP11 9.80E-05 -0.2 221631 at CACNA1I <1.00E-06 -0.42 207182 at GABRA6 <1.00E-06 -0.19 44040 at FBXO41 <1.00E-06 -0.42 211055 s at INVS <1.00E-06 -0.19 209353 s at C1orf76 2.00E-06 -0.42 207041 at MASP2 5.00E-06 -0.19 214668 at C13orf1 2.00E-06 -0.42 211353 at LRRC21 5.00E-06 -0.19 214903 at — 2.00E-06 -0.42 210436 at CCT8 1.30E-05 -0.19 217324 at EPHB1 2.00E-06 -0.42 217048 at SHC1 1.30E-05 -0.19 200774 at C9orf10 3.00E-06 -0.42 207028 at MYCNOS 1.50E-05 -0.19 206586 at CNR2 3.00E-06 -0.42 214145 s at SPTB 1.80E-05 -0.19 221407 at CX36 5.00E-06 -0.42 211472 at PLXNB2 1.90E-05 -0.19 221670 s at LHX3 5.00E-06 -0.42 216140 at — 1.90E-05 -0.19 206130 s at ASGR2 6.00E-06 -0.42 207954 at GATA2 2.30E-05 -0.19 201994 at MORF4L2 9.00E-06 -0.42 216726 at VENTXP1 2.50E-05 -0.19 206520 x at — 1.10E-05 -0.42 208276 at — 2.60E-05 -0.19 207687 at INHBC 1.10E-05 -0.42 206455 s at RHO 2.70E-05 -0.19 219754 at FLJ11016 1.40E-05 -0.42 216201 at — 2.80E-05 -0.19 219367 s at NRP2 1.70E-05 -0.42 206873 at CA6 3.10E-05 -0.19 211682 x at UGT2B28 2.90E-05 -0.42 217381 s at TRGV5 3.10E-05 -0.19 208724 s at RAB1A 3.50E-05 -0.42 207771 at SLC5A2 3.50E-05 -0.19 204713 s at F5 <1.00E-06 -0.41 207578 s at HTR4 3.60E-05 -0.19 207051 at SLC17A4 <1.00E-06 -0.41 215486 at PRPS1L1 3.60E-05 -0.19 207209 at CETN1 <1.00E-06 -0.41 216428 x at FLJ00060 4.10E-05 -0.19 210451 at PKLR <1.00E-06 -0.41 216747 at APBB2 4.60E-05 -0.19 211132 at C1orf60 <1.00E-06 -0.41 218186 at RAB25 4.90E-05 -0.19 215590 x at — <1.00E-06 -0.41 208240 s at FGF1 5.20E-05 -0.19 216824 at LOC442334* <1.00E-06 -0.41 211834 s at TP73L 5.60E-05 -0.19 220441 at FLJ13236 <1.00E-06 -0.41 210584 s at POLDIP3* 5.70E-05 -0.19 206264 at GPLD1 <1.00E-06 -0.41 217219 at DKFZP434A062 6.60E-05 -0.19 210064 s at UPK1B <1.00E-06 -0.41 206475 x at CSH1 7.50E-05 -0.19 216011 at SLC39A9 <1.00E-06 -0.41 210914 at — 7.70E-05 -0.19 221431 s at OR12D3 <1.00E-06 -0.41 216134 at FRMD4B 8.40E-05 -0.19 221457 s at BTNL2 <1.00E-06 -0.41 216833 x at GYPB* 8.60E-05 -0.19 207185 at SLC10A1 2.00E-06 -0.41 217493 x at NCR2 8.60E-05 -0.19 209937 at TM4SF4 2.00E-06 -0.41 207343 at LYZL6 9.10E-05 -0.19 210442 at IL1RL1 2.00E-06 -0.41 213522 s at SLC16A3 9.30E-05 -0.19 211359 s at OPRM1 2.00E-06 -0.41 205737 at KCNQ2 9.60E-05 -0.19 211894 x at SEZ6L 2.00E-06 -0.41 215417 at SEC15L2 <1.00E-06 -0.18 217423 at TTLL2 2.00E-06 -0.41 214397 at MBD2 <1.00E-06 -0.18 206754 s at CYP2B7P1 3.00E-06 -0.41 217634 at LOC387648 2.00E-06 -0.18 220332 at CLDN16 3.00E-06 -0.41 220359 s at ARPP-21 3.00E-06 -0.18 207823 s at AIF1 4.00E-06 -0.41 216935 at C1orf46 8.00E-06 -0.18 216366 x at — 4.00E-06 -0.41 205506 at VIL1 1.10E-05 -0.18 216838 at LOC92249 4.00E-06 -0.41 207772 s at HRMT1L4 1.10E-05 -0.18 213807 x at MET 6.00E-06 -0.41 41553 at C8orf1 1.90E-05 -0.18 214923 at ATP6V1D 1.20E-05 -0.41 213432 at MUC5B 2.20E-05 -0.18 210143 at ANXA10 1.70E-05 -0.41 207885 at S100G 2.40E-05 -0.18 221458 at HTR1F 1.70E-05 -0.41 204814 at CADPS 2.70E-05 -0.18 Myxoﬁbrosarcoma 6

216515 x at PTMA 1.80E-05 -0.41 210274 at MAGEA8 3.60E-05 -0.18 205359 at AKAP6 2.90E-05 -0.41 215174 at FMO6 3.60E-05 -0.18 207608 x at CYP1A2 5.00E-05 -0.41 207381 at ALOX12B 3.90E-05 -0.18 200087 s at TMED2 5.20E-05 -0.41 210929 s at AHSG 4.00E-05 -0.18 207834 at FBLN1 5.20E-05 -0.41 211735 x at SFTPC 4.50E-05 -0.18 215040 at FLJ11712 5.30E-05 -0.41 206427 s at MLANA 4.70E-05 -0.18 219271 at GALNT14 5.60E-05 -0.41 215396 at MASS1 4.80E-05 -0.18 205998 x at CYP3A4 8.70E-05 -0.41 214998 at — 5.00E-05 -0.18 203838 s at TNK2 <1.00E-06 -0.4 207689 at TBX10 5.40E-05 -0.18 205888 s at KIAA0555 <1.00E-06 -0.4 214859 at FSTL4 5.50E-05 -0.18 207716 at KRTHA8 <1.00E-06 -0.4 216337 at — 5.80E-05 -0.18 216431 at — <1.00E-06 -0.4 214161 at C8orf1 6.20E-05 -0.18 217275 at TSSK2 <1.00E-06 -0.4 207308 at SLCO1A2 6.40E-05 -0.18 202885 s at PPP2R1B <1.00E-06 -0.4 215405 at MYO1E 6.80E-05 -0.18 209851 at KIAA0853 <1.00E-06 -0.4 206957 at AGXT 7.40E-05 -0.18 211438 at TRHR <1.00E-06 -0.4 216495 x at — 7.40E-05 -0.18 215060 at — <1.00E-06 -0.4 207324 s at DSC1 7.50E-05 -0.18 215839 at LILRA5 <1.00E-06 -0.4 215426 at ZCCHC14 7.80E-05 -0.18 219194 at SEMA4G <1.00E-06 -0.4 209173 at AGR2 8.20E-05 -0.18 209062 x at NCOA3 2.00E-06 -0.4 216444 at SMURF2 8.90E-05 -0.18 220365 at ALLC 2.00E-06 -0.4 220286 at MTMR10 8.90E-05 -0.18 206979 at C8B 3.00E-06 -0.4 216498 at — 9.20E-05 -0.18 216635 at — 3.00E-06 -0.4 216895 at GABRG3 9.70E-05 -0.18 38447 at ADRBK1 3.00E-06 -0.4 214424 s at ALDOB 5.00E-06 -0.17 207352 s at GABRB2 4.00E-06 -0.4 207583 at ABCD2 6.00E-06 -0.17 204624 at ATP7B 5.00E-06 -0.4 31835 at HRG 6.00E-06 -0.17 214261 s at ADH6 5.00E-06 -0.4 216476 at LOC441320 1.10E-05 -0.17 215906 at — 5.00E-06 -0.4 216513 at DCT 2.40E-05 -0.17 205957 at PLXNB3 6.00E-06 -0.4 206454 s at RHO 4.10E-05 -0.17 205918 at SLC4A3 1.00E-05 -0.4 217129 at — 4.50E-05 -0.17 221467 at MC4R 1.00E-05 -0.4 207202 s at NR1I2 4.90E-05 -0.17 203864 s at ACTN2 1.20E-05 -0.4 213219 at ADCY2 5.50E-05 -0.17 214811 at KIAA0318 1.20E-05 -0.4 220897 at — 5.50E-05 -0.17 215484 at TRIM3 1.20E-05 -0.4 215679 at — 6.10E-05 -0.17 212317 at TNPO3 2.20E-05 -0.4 210843 s at MFAP3L 6.90E-05 -0.17 215821 x at PSG3 2.30E-05 -0.4 221468 at XCR1 7.00E-05 -0.17 210796 x at SIGLEC6 4.70E-05 -0.4 207597 at ADAM18 9.00E-05 -0.17 216714 at CCL13 8.00E-05 -0.4 214565 s at SMR3B* 9.50E-05 -0.17 204723 at SCN3B 8.90E-05 -0.4 204406 at FLT1 9.60E-05 -0.17 203509 at SORL1 9.90E-05 -0.4 214413 at TAT 4.00E-06 -0.16 204637 at CGA <1.00E-06 -0.39 216634 at PLCL3 1.00E-05 -0.16 205021 s at CHES1 <1.00E-06 -0.39 216436 at PIK3R4 2.10E-05 -0.16 206248 at PRKCE <1.00E-06 -0.39 220982 s at SPACA1 2.20E-05 -0.16 208098 at OR5V1* <1.00E-06 -0.39 208220 x at AMELY 2.70E-05 -0.16 215885 at — <1.00E-06 -0.39 220427 at OBSCN 3.00E-05 -0.16 219071 x at C8orf30A <1.00E-06 -0.39 207205 at CEACAM4 3.10E-05 -0.16 220588 at BCAS4 <1.00E-06 -0.39 215769 at TRA@ 4.60E-05 -0.16 221150 at MEPE <1.00E-06 -0.39 211907 s at PARD6B 5.50E-05 -0.16 221297 at GPRC5D <1.00E-06 -0.39 206515 at CYP4F3 5.70E-05 -0.16 221402 at OR1F1 <1.00E-06 -0.39 211525 s at GP5 7.10E-05 -0.16 206062 at GUCA1A <1.00E-06 -0.39 217361 at — 7.90E-05 -0.16 206192 at CDSN <1.00E-06 -0.39 219724 s at KIAA0748 9.00E-05 -0.16 216501 at VAC14 <1.00E-06 -0.39 217670 at RPLP2 9.20E-05 -0.16 220309 at TTC22 <1.00E-06 -0.39 214382 at UNC93A 9.70E-05 -0.16 207964 x at IFNA4 2.00E-06 -0.39 216539 at ATXN3L 9.70E-05 -0.16 222185 at PKNOX2 2.00E-06 -0.39 221144 at — 2.50E-05 -0.15 207683 at FOXN1 7.00E-06 -0.39 220177 s at TMPRSS3 3.20E-05 -0.15 214068 at BEAN 8.00E-06 -0.39 213953 at KRT20 3.70E-05 -0.15 210746 s at EPB42 9.00E-06 -0.39 215097 at CAPZB 4.70E-05 -0.15 220714 at PRDM14 9.00E-06 -0.39 215793 at MTMR7 6.80E-05 -0.15 221910 at ETV1 9.00E-06 -0.39 207731 at — 7.90E-05 -0.15 205190 at PLS1 1.10E-05 -0.39 221343 at OR11A1 8.30E-05 -0.15 213873 at — 1.40E-05 -0.39 217303 s at ADRB3 8.40E-05 -0.15 221859 at SYT13 1.50E-05 -0.39 207259 at FLJ20694 5.00E-06 -0.14 210158 at ERCC4 2.20E-05 -0.39 220844 at TCEB3B 6.20E-05 -0.14 206607 at CBL 2.40E-05 -0.39 217375 at — 7.00E-05 -0.14 214354 x at SFTPB 3.50E-05 -0.39 202612 s at CRSP2 1.30E-05 -0.13 206887 at CCBP2 3.60E-05 -0.39 207633 s at MUSK 7.00E-05 -0.13 201870 at TOMM34 7.10E-05 -0.39 220523 at EFHC2 9.50E-05 -0.12 206904 at MATN1 <1.00E-06 -0.38 214405 at CUGBP2 6.50E-05 0.19 207537 at PFKFB1 <1.00E-06 -0.38 214786 at MAP3K1 1.10E-05 0.23 214147 at C1orf175 <1.00E-06 -0.38 203141 s at AP3B1 5.10E-05 0.23 217273 at PRAMEF10 <1.00E-06 -0.38 216297 at LOC92482 7.40E-05 0.23 220879 at — <1.00E-06 -0.38 213514 s at DIAPH1 1.30E-05 0.25 221629 x at C8orf30A <1.00E-06 -0.38 210828 s at ARNT 4.10E-05 0.25 Myxoﬁbrosarcoma 7

206753 at RDH16 <1.00E-06 -0.38 219608 s at FBXO38 6.80E-05 0.25 206945 at LCT <1.00E-06 -0.38 217602 at PPIA 3.00E-05 0.26 216965 x at SPG20 <1.00E-06 -0.38 215842 s at ATP11A 4.40E-05 0.26 220424 at NPHS2 <1.00E-06 -0.38 208144 s at — 5.40E-05 0.26 203287 at LAD1 2.00E-06 -0.38 213591 at ALDH7A1 5.60E-05 0.27 214624 at UPK1A 2.00E-06 -0.38 201979 s at PPP5C 6.00E-06 0.28 220866 at ADAMTS6 2.00E-06 -0.38 217555 at SMC1L1 9.40E-05 0.28 221241 s at BCL2L14 2.00E-06 -0.38 220488 s at BCAS3 1.40E-05 0.29 213874 at SERPINA4 6.00E-06 -0.38 48580 at CXXC1 2.80E-05 0.3 220665 at LUZP4 7.00E-06 -0.38 45633 at FLJ13912 3.10E-05 0.3 215866 at EEF1G 8.00E-06 -0.38 219266 at ZNF350 4.80E-05 0.3 216730 at — 9.00E-06 -0.38 221650 s at MED18 6.00E-06 0.31 221453 at G6PC2 9.00E-06 -0.38 201155 s at MFN2 4.10E-05 0.31 220138 at HAND1 1.60E-05 -0.38 215439 x at SYNPO2 6.70E-05 0.31 213324 at SRC 1.80E-05 -0.38 213582 at ATP11A <1.00E-06 0.32 204848 x at HBG1 1.90E-05 -0.38 212323 s at VPS13D 2.00E-06 0.32 204680 s at RAPGEF5 2.20E-05 -0.38 205322 s at MTF1 2.20E-05 0.32 217365 at PRAMEF11 2.30E-05 -0.38 208297 s at EVI5 3.80E-05 0.32 210733 at — 3.30E-05 -0.38 44669 at — 4.90E-05 0.32 208281 x at DAZ1 3.80E-05 -0.38 219364 at LGP2 6.80E-05 0.32 216451 at STK38 4.10E-05 -0.38 218040 at PRPF38B 8.20E-05 0.32 59433 at LOC286434 4.50E-05 -0.38 34858 at KCTD2 1.60E-05 0.33 207915 at — 6.70E-05 -0.38 221812 at FBXO42 4.50E-05 0.33 210406 s at RAB6A* 7.00E-05 -0.38 218873 at GON4 6.60E-05 0.33 221510 s at GLS 7.30E-05 -0.38 211200 s at EFCAB2 6.70E-05 0.33 203125 x at SLC11A2 <1.00E-06 -0.37 202301 s at FLJ11021 8.50E-05 0.33 206969 at KRTHA4 <1.00E-06 -0.37 219280 at BRWD1 6.00E-06 0.34 207648 at DRP2 <1.00E-06 -0.37 205545 x at DNAJC8 1.40E-05 0.34 208230 s at NRG1 <1.00E-06 -0.37 215046 at FLJ23861 3.10E-05 0.34 208312 s at PRAMEF1* <1.00E-06 -0.37 202553 s at SYF2 3.60E-05 0.34 210724 at EMR3 <1.00E-06 -0.37 221611 s at PHF7 3.80E-05 0.34 215180 at LOC283761 <1.00E-06 -0.37 215138 s at KIAA1026 5.80E-05 0.34 216149 at DKFZp667M2411 <1.00E-06 -0.37 219969 at CXorf15 6.00E-05 0.34 220082 at PPP1R14D <1.00E-06 -0.37 219876 s at DKFZp434M0331 7.30E-05 0.34 220478 at APOL5 <1.00E-06 -0.37 208709 s at NRD1 9.60E-05 0.34 220857 at — <1.00E-06 -0.37 212324 s at VPS13D 2.00E-06 0.35 221282 x at RUNX2 <1.00E-06 -0.37 215300 s at FMO5 1.30E-05 0.35 206643 at HAL <1.00E-06 -0.37 206652 at ZMYM5 1.60E-05 0.35 206749 at CD1B <1.00E-06 -0.37 214623 at SHFM3P1 2.10E-05 0.35 207858 s at PKLR <1.00E-06 -0.37 204263 s at CPT2 3.30E-05 0.35 208292 at BMP10 <1.00E-06 -0.37 209689 at FLJ10996 5.80E-05 0.35 216919 at TP53I11 <1.00E-06 -0.37 221769 at SPSB3 6.70E-05 0.35 207404 s at HTR1E 2.00E-06 -0.37 213328 at NEK1 7.10E-05 0.35 207973 x at ACRV1 2.00E-06 -0.37 204746 s at PRKCABP 8.30E-05 0.35 220461 at PCNXL2 2.00E-06 -0.37 206441 s at COMMD4 8.80E-05 0.35 220895 at USP29 2.00E-06 -0.37 212791 at FLJ38984 9.50E-05 0.35 221394 at TAAR2 2.00E-06 -0.37 220364 at FLJ11235 1.00E-05 0.36 220873 at REPS2 3.00E-06 -0.37 212491 s at DNAJC8 2.20E-05 0.36 216074 x at KIBRA 6.00E-06 -0.37 201866 s at NR3C1 5.30E-05 0.36 210237 at ARTN 7.00E-06 -0.37 221512 at C1orf160 6.60E-05 0.36 205879 x at RET 8.00E-06 -0.37 221619 s at MTCH1 8.60E-05 0.36 206581 at BNC1 8.00E-06 -0.37 219129 s at SAP30L 9.60E-05 0.36 211295 x at CYP2A6 8.00E-06 -0.37 201164 s at PUM1 2.70E-05 0.37 211460 at TTTY9* 8.00E-06 -0.37 215089 s at RBM10 4.20E-05 0.37 207725 at POU4F2 9.00E-06 -0.37 214299 at TOP3A <1.00E-06 0.38 215341 at LOC200383 9.00E-06 -0.37 219446 at RIC8B <1.00E-06 0.38 216075 at — 9.00E-06 -0.37 220956 s at EGLN2 3.00E-06 0.38 207176 s at CD80 1.00E-05 -0.37 202639 s at RANBP3 4.00E-06 0.38 201249 at SLC2A1 1.20E-05 -0.37 203334 at DHX8 8.00E-06 0.38 208122 x at KIR2DS3 1.40E-05 -0.37 202172 at ZNF161 1.10E-05 0.38 209114 at TSPAN1 1.60E-05 -0.37 203551 s at COX11 1.80E-05 0.38 214485 at ODF1 1.60E-05 -0.37 221700 s at UBA52 1.80E-05 0.38 207314 x at KIR3DL2 1.80E-05 -0.37 201440 at DDX23 5.40E-05 0.38 221862 at KIAA1193 2.40E-05 -0.37 210683 at NRTN 6.30E-05 0.38 209727 at GM2A 3.50E-05 -0.37 211407 at NDUFB7 7.40E-05 0.38 202485 s at MBD2 5.80E-05 -0.37 218676 s at PCTP 7.50E-05 0.38 216130 at PDZRN3 6.20E-05 -0.37 202758 s at RFXANK 9.00E-05 0.38 216750 at APBB2 9.20E-05 -0.37 204080 at TOE1 <1.00E-06 0.39 207258 at DSCR4 <1.00E-06 -0.36 222200 s at BSDC1 5.00E-06 0.39 207504 at CA7 <1.00E-06 -0.36 203353 s at MBD1 1.20E-05 0.39 210682 at LPO <1.00E-06 -0.36 202585 s at NFX1 1.80E-05 0.39 216341 s at GNRHR <1.00E-06 -0.36 213804 at INPP5B 1.90E-05 0.39 217633 at C21orf108 <1.00E-06 -0.36 213772 s at GGA2 2.00E-05 0.39 217676 at — <1.00E-06 -0.36 218304 s at OSBPL11 2.40E-05 0.39 221294 at GPR21 <1.00E-06 -0.36 213505 s at SFRS14 5.20E-05 0.39 Myxoﬁbrosarcoma 8

221382 at — <1.00E-06 -0.36 211228 s at RAD17 5.40E-05 0.39 221409 at OR2S2 <1.00E-06 -0.36 203653 s at COIL 6.10E-05 0.39 206899 at NTSR2 <1.00E-06 -0.36 207006 s at HSU79303 6.40E-05 0.39 206988 at CCL25 <1.00E-06 -0.36 214780 s at MYO9B 6.70E-05 0.39 207020 at HSF2BP <1.00E-06 -0.36 202640 s at RANBP3 9.70E-05 0.39 208379 x at NPY2R <1.00E-06 -0.36 212695 at CRY2 <1.00E-06 0.4 210039 s at PRKCQ <1.00E-06 -0.36 204652 s at NRF1 3.00E-06 0.4 210444 at NPY6R <1.00E-06 -0.36 222151 s at Cep63 5.00E-06 0.4 214495 at CACNG2 <1.00E-06 -0.36 213123 at MFAP3 1.00E-05 0.4 214944 at PHLPPL <1.00E-06 -0.36 200072 s at HNRPM 1.20E-05 0.4 216034 at SUHW1 <1.00E-06 -0.36 40446 at PHF1 2.70E-05 0.4 220671 at CCRN4L <1.00E-06 -0.36 202462 s at DDX46 2.90E-05 0.4 221164 x at CHST5 <1.00E-06 -0.36 221432 s at SLC25A28 3.90E-05 0.4 205004 at NKRF 2.00E-06 -0.36 211289 x at CDC2L1* 6.20E-05 0.4 205587 at FGFR1OP 2.00E-06 -0.36 209698 at CCHCR1 9.30E-05 0.4 208187 s at — 2.00E-06 -0.36 214062 x at NFKBIB 9.90E-05 0.4 214478 at SPP2 2.00E-06 -0.36 218722 s at FLJ12436 9.90E-05 0.4 219992 at TAC3 2.00E-06 -0.36 220298 s at SPATA6 9.00E-06 0.41 221162 at HHLA1 2.00E-06 -0.36 209973 at NFKBIL1 1.20E-05 0.41 221378 at CER1 2.00E-06 -0.36 203520 s at ZNF318 1.60E-05 0.41 221398 at TAS2R8 2.00E-06 -0.36 211363 s at MTAP 1.70E-05 0.41 210271 at NEUROD2 3.00E-06 -0.36 203093 s at TIMM44 2.00E-05 0.41 216852 x at IGLJ3 3.00E-06 -0.36 200955 at IMMT 2.80E-05 0.41 208426 x at KIR2DL4 4.00E-06 -0.36 203984 s at CASP9 3.60E-05 0.41 219645 at CASQ1 4.00E-06 -0.36 209132 s at COMMD4 4.50E-05 0.41 208243 s at CNR1 5.00E-06 -0.36 214250 at NUMA1 4.60E-05 0.41 217295 at MUC8 5.00E-06 -0.36 203602 s at ZBTB17 4.70E-05 0.41 211381 x at SPAG11 9.00E-06 -0.36 202556 s at MCRS1 5.40E-05 0.41 214616 at HIST1H3E 1.30E-05 -0.36 221193 s at ZCCHC10 6.30E-05 0.41 209661 at KIFC3 1.40E-05 -0.36 217857 s at RBM8A 7.50E-05 0.41 220000 at SIGLEC5 1.80E-05 -0.36 206648 at ZNF571 <1.00E-06 0.42 216774 at — 1.90E-05 -0.36 203422 at POLD1 4.00E-06 0.42 216879 at HR44 2.10E-05 -0.36 202494 at PPIE 5.00E-06 0.42 215423 at — 3.20E-05 -0.36 220255 at FANCE 8.00E-06 0.42 217391 x at — 3.20E-05 -0.36 37577 at ARHGAP19 1.30E-05 0.42 220684 at TBX21 3.30E-05 -0.36 217937 s at HDAC7A 1.80E-05 0.42 217077 s at GPR51 3.60E-05 -0.36 218639 s at ZXDC 1.90E-05 0.42 216129 at ATP9A 3.90E-05 -0.36 210537 s at TADA2L 2.30E-05 0.42 201047 x at RAB6A 4.70E-05 -0.36 211578 s at RPS6KB1 2.40E-05 0.42 215864 at INPP4B 5.70E-05 -0.36 222041 at DPH1* 2.50E-05 0.42 213819 s at FLOT1 6.60E-05 -0.36 220739 s at CNNM3 2.70E-05 0.42 219259 at SEMA4A 6.70E-05 -0.36 203302 at DCK 3.80E-05 0.42 217033 x at NTRK3 7.60E-05 -0.36 207855 s at CLCC1 5.70E-05 0.42 208164 s at IL9R* <1.00E-06 -0.35 218370 s at S100PBPR 7.80E-05 0.42 208183 at TACR3 <1.00E-06 -0.35 219088 s at ZNF576 9.10E-05 0.42 211598 x at VIPR2 <1.00E-06 -0.35 203158 s at GLS 9.80E-05 0.42 216445 at PRDM2 <1.00E-06 -0.35 31807 at DDX49 <1.00E-06 0.43 216816 at — <1.00E-06 -0.35 202530 at MAPK14 8.00E-06 0.43 216890 at — <1.00E-06 -0.35 207232 s at DZIP3 1.00E-05 0.43 217001 x at HLA-DOA <1.00E-06 -0.35 219530 at FLJ21816 1.30E-05 0.43 221102 s at TRPM6 <1.00E-06 -0.35 203990 s at UTX 1.50E-05 0.43 221421 s at ADAMTS12 <1.00E-06 -0.35 212740 at PIK3R4 2.30E-05 0.43 215809 at CYP2D6 <1.00E-06 -0.35 207253 s at UBN1 2.80E-05 0.43 221917 s at GRSF1 <1.00E-06 -0.35 211159 s at PPP2R5D 4.10E-05 0.43 206004 at TGM3 2.00E-06 -0.35 203950 s at CLCN6 5.20E-05 0.43 206714 at ALOX15B 2.00E-06 -0.35 201696 at SFRS4 5.40E-05 0.43 214227 at GNG7 2.00E-06 -0.35 211595 s at MRPS11 5.60E-05 0.43 220463 at TRPM3 2.00E-06 -0.35 205068 s at ARHGAP26 7.00E-05 0.43 222102 at GSTA3 2.00E-06 -0.35 217730 at TMBIM1 7.20E-05 0.43 211687 x at KIR3DL1 4.00E-06 -0.35 219303 at C13orf7 8.90E-05 0.43 214178 s at SOX2 4.00E-06 -0.35 204145 at FRG1 9.20E-05 0.43 216429 at — 4.00E-06 -0.35 212564 at KCTD2 <1.00E-06 0.44 211586 s at ATP2B2 5.00E-06 -0.35 220154 at DST 3.00E-06 0.44 219270 at MGC4504 5.00E-06 -0.35 201484 at SUPT4H1 4.00E-06 0.44 217088 s at NCR1 8.00E-06 -0.35 211558 s at DHPS 1.40E-05 0.44 219710 at SH3TC2 1.10E-05 -0.35 221857 s at TJAP1 1.70E-05 0.44 220307 at CD244 1.10E-05 -0.35 204792 s at WDTC2 1.80E-05 0.44 220413 at SLC39A2 1.10E-05 -0.35 208914 at GGA2 2.00E-05 0.44 208004 at PROL1 1.20E-05 -0.35 206491 s at NAPA 2.20E-05 0.44 216848 at KIAA1660 1.60E-05 -0.35 201221 s at SNRP70 5.10E-05 0.44 219121 s at RBM35A 1.70E-05 -0.35 220753 s at CRYL1 5.20E-05 0.44 217039 x at IGHG3 1.80E-05 -0.35 201371 s at CUL3 5.40E-05 0.44 215934 at — 1.90E-05 -0.35 220275 at CUZD1 7.10E-05 0.44 218990 s at SPRR3 2.00E-05 -0.35 220143 x at LUC7L 8.40E-05 0.44 210753 s at EPHB1 2.40E-05 -0.35 218367 x at USP21 <1.00E-06 0.45 Myxoﬁbrosarcoma 9

204943 at ADAM12 2.90E-05 -0.35 201965 s at ALS4 3.00E-06 0.45 205032 at ITGA2 4.00E-05 -0.35 208984 x at RBM10 5.00E-06 0.45 210151 s at DYRK3 4.00E-05 -0.35 210947 s at MSH3 1.30E-05 0.45 220347 at C17orf31 4.50E-05 -0.35 206480 at LTC4S 1.40E-05 0.45 220100 at SLC22A11 4.90E-05 -0.35 208784 s at KLHDC3 1.50E-05 0.45 220944 at PGLYRP4 5.20E-05 -0.35 215739 s at TUBGCP3 2.30E-05 0.45 205318 at KIF5A 5.90E-05 -0.35 209190 s at DIAPH1 2.60E-05 0.45 211195 s at TP73L 7.20E-05 -0.35 219376 at ZNF322B 2.70E-05 0.45 210637 at TACR1 7.90E-05 -0.35 220202 s at MNAB 3.20E-05 0.45 207032 s at CRISP1 <1.00E-06 -0.34 202151 s at UBADC1 5.30E-05 0.45 207035 at SLC30A3 <1.00E-06 -0.34 221937 at AP1GBP1 6.90E-05 0.45 216355 at PCDHB17 <1.00E-06 -0.34 203500 at GCDH 7.00E-05 0.45 216953 s at WT1 <1.00E-06 -0.34 209586 s at PRUNE 7.20E-05 0.45 217405 x at GPLD1 <1.00E-06 -0.34 218004 at BSDC1 3.00E-06 0.46 219404 at EPS8L3 <1.00E-06 -0.34 213403 at MGC11332 5.00E-06 0.46 205102 at TMPRSS2 <1.00E-06 -0.34 207530 s at CDKN2B 8.00E-06 0.46 207251 at MEP1B <1.00E-06 -0.34 215338 s at NKTR 2.10E-05 0.46 214993 at LOC253982 <1.00E-06 -0.34 217903 at STRN4 3.80E-05 0.46 216018 at RNF5 <1.00E-06 -0.34 204297 at PIK3C3 4.80E-05 0.46 217108 at — <1.00E-06 -0.34 207338 s at ZNF200 4.80E-05 0.46 220569 at — <1.00E-06 -0.34 207438 s at RNUT1 5.60E-05 0.46 202938 x at CGI-96* 2.00E-06 -0.34 203364 s at KIAA0652 5.70E-05 0.46 206719 at SYNGR4 2.00E-06 -0.34 210053 at TAF5 5.80E-05 0.46 215523 at LOC346157 2.00E-06 -0.34 221954 at C20orf111 6.10E-05 0.46 220877 at — 2.00E-06 -0.34 203384 s at GOLGA1 7.40E-05 0.46 205464 at SCNN1B 3.00E-06 -0.34 212987 at FBXO9 7.60E-05 0.46 216760 at HRASLS2 3.00E-06 -0.34 221980 at EMILIN2 2.00E-06 0.47 222327 x at OR7E156P 3.00E-06 -0.34 204028 s at RABGAP1 3.00E-06 0.47 33778 at TBC1D22A 3.00E-06 -0.34 221877 at — 4.00E-06 0.47 206850 at RRP22 4.00E-06 -0.34 201748 s at SAFB 8.00E-06 0.47 207184 at SLC6A13 4.00E-06 -0.34 202928 s at PHF1 8.00E-06 0.47 216063 at HBBP1 4.00E-06 -0.34 218161 s at CLN6 8.00E-06 0.47 210708 x at CASP10 5.00E-06 -0.34 42361 g at CCHCR1 8.00E-06 0.47 210991 s at RIMS3 5.00E-06 -0.34 200623 s at CALM3 1.20E-05 0.47 207773 x at CYP3A43 6.00E-06 -0.34 201225 s at SRRM1 2.20E-05 0.47 216287 at OPA1 6.00E-06 -0.34 221246 x at TNS1 2.70E-05 0.47 221236 s at STMN4 6.00E-06 -0.34 208970 s at UROD 3.50E-05 0.47 204583 x at KLK3 7.00E-06 -0.34 210180 s at SFRS10 3.70E-05 0.47 220679 s at CDH7 8.00E-06 -0.34 214402 s at SFI1 3.80E-05 0.47 207298 at SLC17A3 1.00E-05 -0.34 205928 at ZNF443 4.50E-05 0.47 216936 at — 1.00E-05 -0.34 213296 at PEX10 4.50E-05 0.47 220635 at PSORS1C2 1.50E-05 -0.34 201483 s at SUPT4H1 6.30E-05 0.47 206573 at KCNQ3 2.30E-05 -0.34 208094 s at MGC10471 7.20E-05 0.47 214445 at ELL2 2.60E-05 -0.34 202500 at DNAJB2 8.90E-05 0.47 211222 s at HAP1 3.40E-05 -0.34 205045 at AKAP10 <1.00E-06 0.48 213561 at ASF1A 3.40E-05 -0.34 219101 x at ABHD8 <1.00E-06 0.48 206498 at OCA2 3.60E-05 -0.34 214220 s at ALMS1 3.00E-06 0.48 215394 at PIK3C3 3.60E-05 -0.34 200066 at IK 4.00E-06 0.48 220533 at — 3.70E-05 -0.34 213181 s at MOCS1 4.00E-06 0.48 205597 at SLC44A4 4.20E-05 -0.34 221735 at WDR48 4.00E-06 0.48 203839 s at TNK2 5.00E-05 -0.34 212380 at KIAA0082 5.00E-06 0.48 220114 s at STAB2 5.40E-05 -0.34 216488 s at ATP11A 5.00E-06 0.48 208463 at GABRA4 6.70E-05 -0.34 218861 at RNF25 6.00E-06 0.48 205073 at CYP2J2 7.20E-05 -0.34 203893 at TAF9 1.00E-05 0.48 212906 at KIAA1201 7.90E-05 -0.34 215905 s at WDR57 2.30E-05 0.48 221036 s at APH1B 8.20E-05 -0.34 213916 at ZNF20 2.90E-05 0.48 204024 at C8orf1 <1.00E-06 -0.33 217780 at PTD008 3.20E-05 0.48 207519 at SLC6A4 <1.00E-06 -0.33 209600 s at ACOX1 3.40E-05 0.48 208596 s at UGT1A10 <1.00E-06 -0.33 217952 x at PHF3 3.60E-05 0.48 213323 s at ZC3H7B <1.00E-06 -0.33 204021 s at PURA 4.30E-05 0.48 214076 at MGC11335 <1.00E-06 -0.33 215711 s at WEE1 5.40E-05 0.48 214199 at SFTPD <1.00E-06 -0.33 218414 s at NDE1 6.20E-05 0.48 215916 at CHRNE <1.00E-06 -0.33 208021 s at RFC1 7.30E-05 0.48 220811 at PRG3 <1.00E-06 -0.33 203374 s at TPP2 8.10E-05 0.48 221199 at GFRA4 <1.00E-06 -0.33 202592 at BLOC1S1 9.00E-05 0.48 216673 at TTTY1 <1.00E-06 -0.33 212577 at SMCHD1 9.20E-05 0.48 216732 at — <1.00E-06 -0.33 203288 at KIAA0355 9.70E-05 0.48 216800 at — <1.00E-06 -0.33 208971 at UROD <1.00E-06 0.49 217376 at — <1.00E-06 -0.33 221187 s at FLJ22688 <1.00E-06 0.49 217654 at CFLAR <1.00E-06 -0.33 210502 s at PPIE 3.00E-06 0.49 220245 at SLC45A2 <1.00E-06 -0.33 205875 s at TREX1 4.00E-06 0.49 221346 at OR10J1 <1.00E-06 -0.33 206005 s at C6orf84 4.00E-06 0.49 205243 at SLC13A3 2.00E-06 -0.33 212881 at PIAS4 4.00E-06 0.49 206077 at KEL 2.00E-06 -0.33 212756 s at UBR2 5.00E-06 0.49 206799 at SCGB1D2 2.00E-06 -0.33 208922 s at NXF1 7.00E-06 0.49 Myxoﬁbrosarcoma 10

215153 at NOS1AP 2.00E-06 -0.33 212629 s at PKN2 1.00E-05 0.49 208587 s at OR1E1* 3.00E-06 -0.33 218466 at TBC1D17 1.60E-05 0.49 210331 at HECW1 3.00E-06 -0.33 204662 at CP110 1.70E-05 0.49 206783 at FGF4 4.00E-06 -0.33 208772 at ANKHD1* 1.70E-05 0.49 207458 at C8orf51 4.00E-06 -0.33 202123 s at ABL1 1.80E-05 0.49 208521 at OR5I1 4.00E-06 -0.33 206416 at ZNF205 3.10E-05 0.49 215056 at — 4.00E-06 -0.33 201039 s at RAD23A 3.60E-05 0.49 217655 at FXYD5 4.00E-06 -0.33 213396 s at AKAP10 5.40E-05 0.49 211254 x at RHAG 5.00E-06 -0.33 205526 s at KATNA1 7.40E-05 0.49 221612 at HT017 5.00E-06 -0.33 202056 at KPNA1 7.70E-05 0.49 208565 at MC5R 6.00E-06 -0.33 221656 s at ARHGEF10L 8.70E-05 0.49 207409 at LECT2 7.00E-06 -0.33 206175 x at ZNF222 <1.00E-06 0.5 220627 at CST8 7.00E-06 -0.33 208066 s at GTF2B <1.00E-06 0.5 207374 at PLSCR2 1.10E-05 -0.33 212691 at NUP188 <1.00E-06 0.5 209792 s at KLK10 1.20E-05 -0.33 212854 x at DJ328E19.C1.1 2.00E-06 0.5 207646 s at CDY1 1.40E-05 -0.33 218428 s at REV1L 2.00E-06 0.5 208390 s at GLP1R 1.40E-05 -0.33 205418 at FES 3.00E-06 0.5 221332 at BMP15 1.70E-05 -0.33 201763 s at DAXX 4.00E-06 0.5 221460 at OR2C1 1.70E-05 -0.33 220183 s at NUDT6 5.00E-06 0.5 220869 at FLJ10808 2.30E-05 -0.33 221850 x at CTGLF1 5.00E-06 0.5 206534 at GRIN2A 2.40E-05 -0.33 202055 at KPNA1 7.00E-06 0.5 207454 at GRIK3 2.40E-05 -0.33 213454 at APITD1 1.10E-05 0.5 220446 s at CHST4 2.50E-05 -0.33 209268 at VPS45A 1.90E-05 0.5 217120 s at CRSP2 2.90E-05 -0.33 203257 s at MGC4707 2.60E-05 0.5 217449 at — 3.50E-05 -0.33 215287 at — 2.60E-05 0.5 207552 at ATP5G2 4.70E-05 -0.33 212838 at DNMBP 3.40E-05 0.5 207893 at SRY 6.00E-05 -0.33 203822 s at ELF2 3.80E-05 0.5 215762 at — 6.70E-05 -0.33 218601 at URG4 4.10E-05 0.5 215126 at — 7.10E-05 -0.33 202630 at APPBP2 4.60E-05 0.5 215527 at KHDRBS2 7.70E-05 -0.33 218845 at DUSP22 5.40E-05 0.5 208408 at PTN 9.40E-05 -0.33 204864 s at IL6ST 8.10E-05 0.5 205030 at FABP7 <1.00E-06 -0.32 214736 s at ADD1 <1.00E-06 0.51 207889 at SARDH <1.00E-06 -0.32 212945 s at MGA <1.00E-06 0.51 209842 at SOX10 <1.00E-06 -0.32 218766 s at WARS2 2.00E-06 0.51 217397 at — <1.00E-06 -0.32 217221 x at RBM10 3.00E-06 0.51 221354 s at GPR24 <1.00E-06 -0.32 213728 at LAMP1 5.00E-06 0.51 205589 at MYL3 <1.00E-06 -0.32 220864 s at NDUFA13 1.00E-05 0.51 207094 at IL8RA <1.00E-06 -0.32 211975 at ZNF289 1.20E-05 0.51 214215 s at KIAA0217 <1.00E-06 -0.32 217872 at FLJ20643 1.30E-05 0.51 214704 at KIAA1049 <1.00E-06 -0.32 202947 s at GYPC 1.60E-05 0.51 220069 at TUBA8 <1.00E-06 -0.32 206414 s at DDEF2 2.20E-05 0.51 221072 at MOST2 <1.00E-06 -0.32 219905 at ERMAP 2.60E-05 0.51 91920 at BCAN <1.00E-06 -0.32 220744 s at WDR10 2.90E-05 0.51 215798 at ALDH1L1 2.00E-06 -0.32 201104 x at DJ328E19.C1.1 3.40E-05 0.51 216404 at KLHL1AS 2.00E-06 -0.32 209450 at OSGEP 3.80E-05 0.51 216578 at — 2.00E-06 -0.32 210188 at GABPA 3.90E-05 0.51 216955 at TAF1 2.00E-06 -0.32 204817 at ESPL1 4.00E-05 0.51 219946 x at MYH14 2.00E-06 -0.32 208819 at RAB8A 4.30E-05 0.51 206123 at LLGL1 3.00E-06 -0.32 218476 at POMT1 4.60E-05 0.51 207665 at ADAM21 3.00E-06 -0.32 209020 at C20orf111 5.40E-05 0.51 207859 s at CHRNB3 3.00E-06 -0.32 209252 at HARSL <1.00E-06 0.52 210925 at CIITA 3.00E-06 -0.32 218488 at EIF2B3 <1.00E-06 0.52 213999 at MGC11061 3.00E-06 -0.32 217965 s at HCNGP <1.00E-06 0.52 215808 at KLK10 3.00E-06 -0.32 207831 x at DHPS 2.00E-06 0.52 217020 at RARB 3.00E-06 -0.32 217923 at PEF1 4.00E-06 0.52 219732 at PRG-3 3.00E-06 -0.32 201964 at ALS4 5.00E-06 0.52 206775 at CUBN 4.00E-06 -0.32 202387 at BAG1 9.00E-06 0.52 211481 at SLCO1A2 5.00E-06 -0.32 218855 at GPR175 1.20E-05 0.52 216892 at IGHG3 5.00E-06 -0.32 209411 s at GGA3 1.40E-05 0.52 220782 x at KLK12 5.00E-06 -0.32 222237 s at ZNF228 1.80E-05 0.52 207268 x at ABI2 6.00E-06 -0.32 204868 at ICT1 3.30E-05 0.52 210850 s at ELK1 7.00E-06 -0.32 209068 at HNRPDL 4.30E-05 0.52 217215 s at — 7.00E-06 -0.32 221949 at LOC222070 4.30E-05 0.52 221314 at GDF9 7.00E-06 -0.32 201906 s at CTDSPL 5.80E-05 0.52 211900 x at CD6 8.00E-06 -0.32 209467 s at MKNK1 9.10E-05 0.52 220852 at PRO1768 9.00E-06 -0.32 200857 s at NCOR1 9.80E-05 0.52 220808 at THEG 1.00E-05 -0.32 210461 s at ABLIM1 2.00E-06 0.53 221615 at BMP8B 1.20E-05 -0.32 207394 at ZNF137 4.00E-06 0.53 216615 s at HTR3A 1.40E-05 -0.32 212326 at VPS13D 5.00E-06 0.53 217330 at DISC1 1.80E-05 -0.32 218587 s at MDSRP 1.30E-05 0.53 215620 at RREB1 2.00E-05 -0.32 219011 at PLEKHA4 3.30E-05 0.53 210040 at SLC12A5 2.30E-05 -0.32 212300 at TXLNA 4.90E-05 0.53 216357 at SNX1 2.50E-05 -0.32 209234 at KIF1B 5.30E-05 0.53 216354 at — 2.70E-05 -0.32 209980 s at SHMT1 6.10E-05 0.53 216688 at — 2.70E-05 -0.32 215084 s at LRRC42 8.30E-05 0.53 Myxoﬁbrosarcoma 11

216993 s at COL11A2 2.70E-05 -0.32 220219 s at LRRC37A <1.00E-06 0.54 219633 at C20orf121 3.10E-05 -0.32 209019 s at PINK1 3.00E-06 0.54 210604 at GNAT2 3.70E-05 -0.32 213261 at LBA1 3.00E-06 0.54 205929 at GPA33 4.00E-05 -0.32 218733 at RNF184 3.00E-06 0.54 220045 at NEUROD6 4.40E-05 -0.32 213313 at RABGAP1 5.00E-06 0.54 207356 at DEFB4 4.90E-05 -0.32 210474 s at CDC2L1* 7.00E-06 0.54 222298 at COPG2 5.30E-05 -0.32 209503 s at PSMC5 1.20E-05 0.54 217374 x at TRGV5 5.90E-05 -0.32 219067 s at C10orf86 1.90E-05 0.54 206859 s at PAEP 6.70E-05 -0.32 208879 x at C20orf14 2.80E-05 0.54 218406 x at NENF 7.50E-05 -0.32 209055 s at CDC5L 2.90E-05 0.54 214646 at HIST1H3J 9.90E-05 -0.32 218533 s at UCKL1 4.00E-05 0.54 219610 at RGNEF 9.90E-05 -0.32 202548 s at ARHGEF7 7.90E-05 0.54 207187 at JAK3 <1.00E-06 -0.31 204538 x at NPIP 8.50E-05 0.54 207701 at C22orf24 <1.00E-06 -0.31 219047 s at ZNF668 9.10E-05 0.54 207899 at GIP <1.00E-06 -0.31 204739 at CENPC1 <1.00E-06 0.55 208382 s at DMC1 <1.00E-06 -0.31 205025 at HKR3 2.00E-06 0.55 211123 at SLC5A5 <1.00E-06 -0.31 220019 s at ZNF224 2.00E-06 0.55 214628 at NHLH1 <1.00E-06 -0.31 215215 s at LOC81691 8.00E-06 0.55 216807 at KIAA1751 <1.00E-06 -0.31 220094 s at C6orf79 1.40E-05 0.55 216972 at SPAM1 <1.00E-06 -0.31 222236 s at DDEFL1 1.40E-05 0.55 204685 s at ATP2B2 <1.00E-06 -0.31 210667 s at C21orf33 2.00E-05 0.55 205216 s at APOH <1.00E-06 -0.31 203976 s at CHAF1A 2.60E-05 0.55 206671 at SAG <1.00E-06 -0.31 206929 s at NFIC 2.70E-05 0.55 207459 x at GYPB <1.00E-06 -0.31 219952 s at MCOLN1 2.70E-05 0.55 207553 at OPRK1 <1.00E-06 -0.31 221188 s at CIDEB 2.90E-05 0.55 208124 s at SEMA4F <1.00E-06 -0.31 209056 s at CDC5L 3.10E-05 0.55 210545 at ITSN2 <1.00E-06 -0.31 212257 s at SMARCA2 3.20E-05 0.55 211201 at FSHR <1.00E-06 -0.31 219284 at HSPBAP1 3.70E-05 0.55 215584 at HECW1 <1.00E-06 -0.31 211890 x at CAPN3 4.00E-05 0.55 215840 at FLJ46675 <1.00E-06 -0.31 210178 x at FUSIP1 6.50E-05 0.55 216507 at FLJ90013 <1.00E-06 -0.31 203763 at D2LIC 6.70E-05 0.55 217096 at PCLO <1.00E-06 -0.31 213341 at FEM1C 7.00E-05 0.55 219692 at KREMEN2 <1.00E-06 -0.31 211569 s at HADHSC 8.10E-05 0.55 219832 s at HOXC13 <1.00E-06 -0.31 221135 s at HT001 <1.00E-06 0.56 205284 at KIAA0133 2.00E-06 -0.31 212785 s at HDCMA18P <1.00E-06 0.56 205305 at FGL1 2.00E-06 -0.31 211475 s at BAG1 3.00E-06 0.56 205635 at KALRN 2.00E-06 -0.31 222336 at LOC201895 1.00E-05 0.56 206747 at KIAA0514 2.00E-06 -0.31 203567 s at TRIM38 1.50E-05 0.56 220722 s at SLC5A7 2.00E-06 -0.31 202326 at EHMT2 1.60E-05 0.56 210924 at OLFM1 3.00E-06 -0.31 221888 at CC2D1A 7.30E-05 0.56 216552 x at KIR2DS4 3.00E-06 -0.31 203135 at TBP <1.00E-06 0.57 217395 at MT4 3.00E-06 -0.31 210266 s at TRIM33 <1.00E-06 0.57 204782 at — 4.00E-06 -0.31 205329 s at SNX4 <1.00E-06 0.57 207814 at DEFA6 4.00E-06 -0.31 219518 s at ELL3 <1.00E-06 0.57 214694 at M-RIP 4.00E-06 -0.31 210350 x at ING1 2.00E-06 0.57 217160 at TSPY1 4.00E-06 -0.31 203514 at MAP3K3 3.00E-06 0.57 210200 at WWP2 5.00E-06 -0.31 213471 at NPHP4 4.00E-06 0.57 211587 x at CHRNA3 5.00E-06 -0.31 202927 at PIN1 5.00E-06 0.57 211606 at — 5.00E-06 -0.31 202959 at MUT 1.60E-05 0.57 208314 at RRH 6.00E-06 -0.31 215920 s at LOC283970* 1.80E-05 0.57 212679 at TBL2 6.00E-06 -0.31 202583 s at RANBP9 1.90E-05 0.57 221464 at OR1D2 6.00E-06 -0.31 211000 s at IL6ST 2.10E-05 0.57 216762 at ANKRD15 8.00E-06 -0.31 216969 s at KIF22 2.20E-05 0.57 39763 at HPX 8.00E-06 -0.31 219278 at MAP3K6 6.50E-05 0.57 213962 s at KIAA0692 9.00E-06 -0.31 205760 s at OGG1 6.80E-05 0.57 220747 at HSPC072 9.00E-06 -0.31 201555 at MCM3 8.00E-05 0.57 221084 at HTR3B 9.00E-06 -0.31 203160 s at RNF8 <1.00E-06 0.58 206774 at FRMPD1 1.20E-05 -0.31 219286 s at RBM15 <1.00E-06 0.58 221466 at P2RY4 1.20E-05 -0.31 213204 at PARC 4.00E-06 0.58 217342 x at FLJ11292 1.30E-05 -0.31 209759 s at DCI 9.00E-06 0.58 220645 at FAM55D 1.40E-05 -0.31 213660 s at TOP3B 9.00E-06 0.58 214529 at TSHB 1.50E-05 -0.31 215170 s at Cep152 1.10E-05 0.58 210403 s at KCNJ1 1.80E-05 -0.31 219103 at DDEFL1 1.20E-05 0.58 206160 at APOBEC2 2.30E-05 -0.31 215882 at Cep152 1.30E-05 0.58 211439 at SFRS7 2.30E-05 -0.31 201970 s at NASP 2.10E-05 0.58 219031 s at CGI-37 2.40E-05 -0.31 212249 at PIK3R1 2.80E-05 0.58 220344 at C11orf16 3.00E-05 -0.31 219247 s at ZDHHC14 3.70E-05 0.58 221209 s at OTOR 3.10E-05 -0.31 203689 s at FMR1 3.90E-05 0.58 211718 at MGC2889 3.20E-05 -0.31 207856 s at FLJ20297* 4.80E-05 0.58 208466 at RAB3D 3.60E-05 -0.31 217754 at DDX56 4.90E-05 0.58 217187 at MUC5AC 3.70E-05 -0.31 211043 s at CLTB 5.20E-05 0.58 216785 at FKBP1B 3.90E-05 -0.31 202596 at ENSA <1.00E-06 0.59 213209 at TAF6L 4.20E-05 -0.31 217714 x at STMN1 <1.00E-06 0.59 215771 x at RET 4.30E-05 -0.31 220935 s at CDK5RAP2 <1.00E-06 0.59 217358 at DNAJC16 4.40E-05 -0.31 221971 x at CTGLF1 <1.00E-06 0.59 Myxoﬁbrosarcoma 12

220073 s at PLEKHG6 4.70E-05 -0.31 214268 s at MTMR4 5.00E-06 0.59 215557 at SCD4 5.90E-05 -0.31 206959 s at UPF3A 6.00E-06 0.59 204607 at HMGCS2 6.70E-05 -0.31 201935 s at EIF4G3 1.80E-05 0.59 220375 s at — 7.60E-05 -0.31 203056 s at PRDM2 1.80E-05 0.59 207200 at OTC 8.00E-05 -0.31 221272 s at C1orf21 2.00E-05 0.59 216815 at — 8.50E-05 -0.31 221427 s at CCNL2 3.70E-05 0.59 205749 at CYP1A1 <1.00E-06 -0.3 217902 s at HERC2 5.40E-05 0.59 211188 at CD84 <1.00E-06 -0.3 35617 at MAPK7 8.10E-05 0.59 211912 at MERTK <1.00E-06 -0.3 218350 s at GMNN 8.90E-05 0.59 215927 at MUC1 <1.00E-06 -0.3 200802 at SARS <1.00E-06 0.6 204213 at PIGR <1.00E-06 -0.3 203482 at C10orf6 <1.00E-06 0.6 204743 at TAGLN3 <1.00E-06 -0.3 215926 x at SNAPC4 <1.00E-06 0.6 205919 at HBE1 <1.00E-06 -0.3 218221 at ARNT <1.00E-06 0.6 206430 at CDX1 <1.00E-06 -0.3 201747 s at SAFB <1.00E-06 0.6 206733 at TULP2 <1.00E-06 -0.3 203655 at XRCC1 <1.00E-06 0.6 210229 s at CSF2 <1.00E-06 -0.3 209106 at NCOA1 4.00E-06 0.6 214926 at SPTAN1 <1.00E-06 -0.3 218522 s at BPY2IP1 4.00E-06 0.6 215688 at RASGRF1 <1.00E-06 -0.3 218827 s at Cep192 5.00E-06 0.6 220660 at C9orf27 <1.00E-06 -0.3 212715 s at MICAL3 2.30E-05 0.6 220713 at MGC4707 <1.00E-06 -0.3 209688 s at FLJ10996 5.60E-05 0.6 221186 at — <1.00E-06 -0.3 208782 at FSTL1 6.20E-05 0.6 221396 at TAS2R7 <1.00E-06 -0.3 217627 at ZNF573 7.80E-05 0.6 204505 s at EPB49 2.00E-06 -0.3 202487 s at H2AFV 8.40E-05 0.6 216998 s at ADAM5 2.00E-06 -0.3 220095 at C9orf39 8.70E-05 0.6 222301 at CROC4 2.00E-06 -0.3 203992 s at UTX 8.80E-05 0.6 214108 at MAX 3.00E-06 -0.3 204860 s at BIRC1 9.70E-05 0.6 221370 at LOC377064 3.00E-06 -0.3 202802 at DHPS <1.00E-06 0.61 207533 at CCL1 5.00E-06 -0.3 219375 at CEPT1 <1.00E-06 0.61 210363 s at SCN2B 5.00E-06 -0.3 201749 at ECE1 <1.00E-06 0.61 215822 x at MYT1 5.00E-06 -0.3 212557 at ZNF451 6.00E-06 0.61 206934 at SIRPB1 6.00E-06 -0.3 211823 s at PXN 7.00E-06 0.61 210841 s at NRP2 6.00E-06 -0.3 209113 s at HMG20B 1.00E-05 0.61 214627 at EPX 8.00E-06 -0.3 209807 s at NFIX 3.20E-05 0.61 214990 at PIGO 9.00E-06 -0.3 213208 at KIAA0240 <1.00E-06 0.62 221546 at PRPF18 9.00E-06 -0.3 219994 at APBB1IP <1.00E-06 0.62 208179 x at KIR2DL3 1.10E-05 -0.3 203026 at ZBTB5 <1.00E-06 0.62 214139 at — 1.10E-05 -0.3 214940 s at C17orf31 <1.00E-06 0.62 210103 s at FOXA2 1.20E-05 -0.3 206980 s at FLT3LG 3.00E-06 0.62 207919 at ART1 1.30E-05 -0.3 211950 at RBAF600 4.00E-06 0.62 207816 at LALBA 1.60E-05 -0.3 209782 s at DBP 8.00E-06 0.62 205643 s at PPP2R2B 1.70E-05 -0.3 202102 s at BRD4 1.10E-05 0.62 207774 at ATG10 1.70E-05 -0.3 209832 s at CDT1 2.30E-05 0.62 204733 at KLK6 1.80E-05 -0.3 216831 s at RUNX1T1 2.30E-05 0.62 206109 at FUT1 2.00E-05 -0.3 200685 at SFRS11 3.80E-05 0.62 221448 s at TEX15 2.00E-05 -0.3 215016 x at DST 6.80E-05 0.62 200097 s at HNRPK 2.30E-05 -0.3 202414 at ERCC5 7.50E-05 0.62 206698 at XK 2.50E-05 -0.3 207304 at ZNF45 <1.00E-06 0.63 211583 x at NCR3 2.50E-05 -0.3 218958 at FLJ20850 <1.00E-06 0.63 217082 at — 2.60E-05 -0.3 217502 at IFIT2 5.00E-06 0.63 216787 at FKBP1B 3.00E-05 -0.3 204867 at GCHFR 9.00E-06 0.63 217708 x at BRAP 3.10E-05 -0.3 205201 at GLI3 1.60E-05 0.63 221465 at OR6A2 3.20E-05 -0.3 218524 at E4F1 1.70E-05 0.63 215430 at GK2 3.30E-05 -0.3 208107 s at LOC81691 <1.00E-06 0.64 206000 at MEP1A 3.40E-05 -0.3 219322 s at WDR8 <1.00E-06 0.64 206681 x at GP2 3.50E-05 -0.3 213483 at PPWD1 <1.00E-06 0.64 211245 x at KIR2DL4 3.80E-05 -0.3 218215 s at NR1H2 1.00E-05 0.64 215700 x at CPNE6 4.70E-05 -0.3 207081 s at PIK4CA 2.20E-05 0.64 206692 at KCNJ10 6.10E-05 -0.3 201036 s at HADHSC 2.50E-05 0.64 220887 at C14orf162 6.80E-05 -0.3 218999 at FLJ11000 5.50E-05 0.64 205136 s at NUFIP1 6.90E-05 -0.3 216952 s at LMNB2 5.60E-05 0.64 215129 at PIK3C2G 6.90E-05 -0.3 202107 s at MCM2 7.30E-05 0.64 215639 at SH2D3C 7.00E-05 -0.3 204835 at POLA 9.80E-05 0.64 35150 at CD40 7.00E-05 -0.3 207541 s at EXOSC10 <1.00E-06 0.65 208038 at IL1RL2 7.10E-05 -0.3 217403 s at ZNF227 <1.00E-06 0.65 211483 x at CAMK2B 7.60E-05 -0.3 218058 at CXXC1 <1.00E-06 0.65 207443 at NR2E1 <1.00E-06 -0.29 221711 s at HSPC142 <1.00E-06 0.65 208168 s at CHIT1 <1.00E-06 -0.29 201282 at OGDH 3.00E-06 0.65 211176 s at PAX4 <1.00E-06 -0.29 207813 s at FDXR 3.00E-06 0.65 213602 s at — <1.00E-06 -0.29 212717 at PLEKHM1 5.00E-06 0.65 213796 at SPRR1A <1.00E-06 -0.29 218388 at PGLS 7.00E-06 0.65 215053 at SRCAP <1.00E-06 -0.29 202053 s at ALDH3A2 9.00E-06 0.65 215964 at SNTG1 <1.00E-06 -0.29 221858 at TBC1D12 3.20E-05 0.65 216159 s at — <1.00E-06 -0.29 221218 s at TPK1 5.00E-05 0.65 216475 at — <1.00E-06 -0.29 202806 at DBN1 6.90E-05 0.65 216825 s at MPL <1.00E-06 -0.29 216237 s at MCM5 9.70E-05 0.65 Myxoﬁbrosarcoma 13

219752 at RASAL1 <1.00E-06 -0.29 202631 s at APPBP2 <1.00E-06 0.66 206886 x at GH1 <1.00E-06 -0.29 209996 x at PCM1 <1.00E-06 0.66 221074 at NCR2 <1.00E-06 -0.29 213009 s at TRIM37 <1.00E-06 0.66 221180 at YSK4 <1.00E-06 -0.29 219861 at DNAJC17 <1.00E-06 0.66 221318 at NEUROD4 <1.00E-06 -0.29 204899 s at SAP30 2.00E-06 0.66 205900 at KRT1 2.00E-06 -0.29 214925 s at SPTAN1 2.00E-06 0.66 216154 at GPC5 2.00E-06 -0.29 200940 s at RERE 4.00E-06 0.66 220870 at — 2.00E-06 -0.29 218031 s at CHES1 1.00E-05 0.66 215961 at F12 3.00E-06 -0.29 200783 s at STMN1 1.20E-05 0.66 207052 at HAVCR1 4.00E-06 -0.29 206016 at CCDC22 6.60E-05 0.66 211186 s at AAK1 4.00E-06 -0.29 219818 s at GPATC1 <1.00E-06 0.67 215788 at LOC339457 4.00E-06 -0.29 202227 s at BRD8 <1.00E-06 0.67 216364 s at AFF2 4.00E-06 -0.29 217950 at NOSIP 3.00E-06 0.67 207521 s at ATP2A3 5.00E-06 -0.29 213526 s at PSENEN* 4.00E-06 0.67 210928 at CNOT2 5.00E-06 -0.29 219940 s at FLJ11305 5.00E-06 0.67 214957 at ACTL8 5.00E-06 -0.29 204513 s at ELMO1 9.00E-06 0.67 221414 s at DEFB126 6.00E-06 -0.29 209040 s at PSMB8 2.10E-05 0.67 208007 at — 7.00E-06 -0.29 201969 at NASP 3.00E-05 0.67 206672 at AQP2 8.00E-06 -0.29 221860 at — 6.00E-05 0.67 207249 s at SLC28A2 8.00E-06 -0.29 221747 at TNS 7.70E-05 0.67 209915 s at NRXN1 8.00E-06 -0.29 218014 at PCNT1 <1.00E-06 0.68 215391 at MAP1A 8.00E-06 -0.29 219116 s at DCUN1D2 <1.00E-06 0.68 215275 at TRAF3IP3 9.00E-06 -0.29 222028 at ZNF45 <1.00E-06 0.68 206628 at SLC5A1 1.00E-05 -0.29 212621 at KIAA0286 <1.00E-06 0.68 207825 s at GHRHR 1.00E-05 -0.29 218801 at UGCGL2 4.00E-06 0.68 206010 at HABP2 1.20E-05 -0.29 222357 at ZBTB20 7.00E-06 0.68 220834 at MS4A12 1.50E-05 -0.29 211519 s at KIF2C 1.10E-05 0.68 221392 at TAS2R4 1.50E-05 -0.29 218831 s at FCGRT 2.10E-05 0.68 220624 s at ELF5 1.60E-05 -0.29 201764 at MGC5576 3.40E-05 0.68 221295 at CIDEA 1.80E-05 -0.29 57715 at FAM26B 6.10E-05 0.68 39854 r at PNPLA2 2.20E-05 -0.29 204214 s at RAB32 6.90E-05 0.68 220826 at C21orf77 2.50E-05 -0.29 215004 s at SF4 <1.00E-06 0.69 208524 at GPR15 2.80E-05 -0.29 221725 at WASF2 <1.00E-06 0.69 210288 at KLRG1 2.90E-05 -0.29 213331 s at NEK1 <1.00E-06 0.69 221929 at LOC389677 2.90E-05 -0.29 215903 s at MAST2 7.00E-06 0.69 220197 at ATP6V0A4 3.00E-05 -0.29 219549 s at RTN3 1.30E-05 0.69 220343 at PDE7B 3.70E-05 -0.29 40016 g at MAST4 3.60E-05 0.69 211258 s at TGFA 4.30E-05 -0.29 218585 s at DTL 8.50E-05 0.69 206696 at GPR143 4.50E-05 -0.29 201996 s at SPEN <1.00E-06 0.7 217260 x at IGHM 4.50E-05 -0.29 201529 s at RPA1 <1.00E-06 0.7 218814 s at C1orf75 4.90E-05 -0.29 51200 at FLJ20850 2.00E-06 0.7 208409 at SLC14A2 5.20E-05 -0.29 218518 at C5orf5 3.00E-06 0.7 217192 s at PRDM1 5.30E-05 -0.29 212419 at C10orf56 5.00E-06 0.7 220745 at IL19 5.50E-05 -0.29 204147 s at TFDP1 1.30E-05 0.7 220514 at NAP1L4 5.80E-05 -0.29 217025 s at DBN1 3.20E-05 0.7 216871 at — 6.50E-05 -0.29 219264 s at PPP2R3B <1.00E-06 0.71 211773 s at ZNF306 6.70E-05 -0.29 219132 at PELI2 2.70E-05 0.71 205813 s at MAT1A 7.50E-05 -0.29 203554 x at PTTG1 3.30E-05 0.71 219921 s at DOCK5 8.90E-05 -0.29 216264 s at LAMB2 7.40E-05 0.71 209978 s at LPA* <1.00E-06 -0.28 37425 g at CCHCR1 <1.00E-06 0.72 211590 x at TBXA2R <1.00E-06 -0.28 215235 at SPTAN1 2.00E-06 0.72 213487 at LOC407835 <1.00E-06 -0.28 206767 at RBMS3 3.00E-06 0.72 213912 at KIAA0984 <1.00E-06 -0.28 210758 at PSIP1 6.00E-06 0.72 217042 at RDH11 <1.00E-06 -0.28 214742 at AZI1 6.00E-06 0.72 220816 at EDG7 <1.00E-06 -0.28 206956 at BGLAP* 1.10E-05 0.72 222093 s at ZNHIT4 <1.00E-06 -0.28 202201 at BLVRB 1.20E-05 0.72 222254 at — <1.00E-06 -0.28 206544 x at SMARCA2 1.60E-05 0.72 36907 at MVK <1.00E-06 -0.28 203145 at SPAG5 2.10E-05 0.72 206784 at AQP8 <1.00E-06 -0.28 209394 at ASMTL 2.50E-05 0.72 214275 at MED12 <1.00E-06 -0.28 201718 s at EPB41L2 2.90E-05 0.72 214358 at ACACA <1.00E-06 -0.28 202598 at S100A13 4.00E-05 0.72 214822 at FAM5B <1.00E-06 -0.28 201061 s at STOM 7.30E-05 0.72 217128 s at CAMK1G <1.00E-06 -0.28 210607 at FLT3LG <1.00E-06 0.73 221945 at FBXO41 <1.00E-06 -0.28 204805 s at H1FX <1.00E-06 0.73 202849 x at GRK6 2.00E-06 -0.28 210269 s at DXYS155E <1.00E-06 0.73 210391 at NR6A1 2.00E-06 -0.28 210201 x at BIN1 2.00E-06 0.73 216545 at LOC441886 2.00E-06 -0.28 201423 s at CUL4A 3.00E-06 0.73 221271 at IL21 2.00E-06 -0.28 210202 s at BIN1 6.00E-06 0.73 222083 at GLYAT 2.00E-06 -0.28 219306 at KIF15 2.30E-05 0.73 206741 at LOC51066 3.00E-06 -0.28 201302 at ANXA4 2.70E-05 0.73 207615 s at C16orf3 3.00E-06 -0.28 204143 s at ENOSF1 4.50E-05 0.73 208477 at KCNC1 3.00E-06 -0.28 220295 x at DEPDC1 5.50E-05 0.73 214538 x at RGS6 3.00E-06 -0.28 205167 s at CDC25C <1.00E-06 0.74 219883 at KCNK4 4.00E-06 -0.28 213116 at NEK3 <1.00E-06 0.74 205365 at HOXB6 5.00E-06 -0.28 218080 x at FAF1 <1.00E-06 0.74 Myxoﬁbrosarcoma 14

205927 s at CTSE 5.00E-06 -0.28 218986 s at FLJ20035 <1.00E-06 0.74 205939 at CYP3A7 5.00E-06 -0.28 221264 s at TARDBP <1.00E-06 0.74 210315 at SYN2 5.00E-06 -0.28 205111 s at PLCE1 4.00E-06 0.74 215755 at — 5.00E-06 -0.28 205805 s at ROR1 9.00E-06 0.74 214286 at GNAT1 6.00E-06 -0.28 214077 x at MEIS4 1.40E-05 0.74 221197 s at CHAT 6.00E-06 -0.28 218308 at TACC3 1.40E-05 0.74 206413 s at TCL1B* 7.00E-06 -0.28 220319 s at MYLIP 2.90E-05 0.74 216360 x at KIAA0690 7.00E-06 -0.28 213546 at DKFZp586I1420 6.20E-05 0.74 207243 s at CALM2 9.00E-06 -0.28 204566 at PPM1D <1.00E-06 0.75 208157 at SIM2 1.20E-05 -0.28 210811 s at DDX49 <1.00E-06 0.75 213276 at CAMK2B 1.40E-05 -0.28 212830 at EGFL5 <1.00E-06 0.75 213921 at SST 1.40E-05 -0.28 213216 at OTUD3 <1.00E-06 0.75 209977 at PLG 1.50E-05 -0.28 202931 x at BIN1 <1.00E-06 0.75 220042 x at HIVEP3 1.60E-05 -0.28 214439 x at BIN1 <1.00E-06 0.75 216072 at HRMT1L1 1.70E-05 -0.28 205543 at HSPA4L 7.00E-06 0.75 208304 at CCR3 1.80E-05 -0.28 36554 at ASMTL 3.80E-05 0.75 215480 at KIAA0509 1.80E-05 -0.28 203751 x at JUND 8.40E-05 0.75 221303 at PCDHB1 2.00E-05 -0.28 205552 s at OAS1 8.50E-05 0.75 211231 x at CYP4A11 2.20E-05 -0.28 212801 at CIT 2.00E-06 0.76 216728 at — 2.20E-05 -0.28 205398 s at SMAD3 5.00E-06 0.76 204393 s at ACPP 2.30E-05 -0.28 218110 at XAB2 5.00E-06 0.76 220611 at DAB1 2.30E-05 -0.28 221988 at MGC2747 9.00E-06 0.76 214490 at ARSF 2.40E-05 -0.28 212325 at KIAA1102 2.10E-05 0.76 208514 at KCNE1 2.80E-05 -0.28 206284 x at CLTB 3.50E-05 0.76 210232 at CDC42 3.40E-05 -0.28 213346 at LOC93081 3.50E-05 0.76 205557 at BPI 3.50E-05 -0.28 211467 s at NFIB 6.00E-05 0.76 221328 at CLDN17 3.60E-05 -0.28 320 at PEX6 <1.00E-06 0.77 206834 at HBD 4.00E-05 -0.28 221591 s at FAM64A 2.00E-06 0.77 208059 at CCR8 4.10E-05 -0.28 201896 s at PSRC1 3.00E-06 0.77 210923 at SLC1A7 4.10E-05 -0.28 203375 s at TPP2 4.00E-06 0.77 216914 at CDC25C 4.10E-05 -0.28 218248 at FLJ22794 7.00E-06 0.77 207216 at TNFSF8 4.20E-05 -0.28 212990 at SYNJ1 1.00E-05 0.77 208462 s at ABCC9 4.20E-05 -0.28 209683 at FAM49A 9.90E-05 0.77 216009 at SLC39A9 4.30E-05 -0.28 202093 s at PAF1 <1.00E-06 0.78 211039 at CHRNA1 5.10E-05 -0.28 208336 s at GPSN2 <1.00E-06 0.78 213697 at HIPK3 5.10E-05 -0.28 220751 s at C5orf4 <1.00E-06 0.78 215672 s at KIAA0828 5.10E-05 -0.28 202839 s at NDUFB7 <1.00E-06 0.78 203807 x at CSH2 5.20E-05 -0.28 219566 at PLEKHF1 2.00E-06 0.78 220310 at TUBAL3 6.10E-05 -0.28 204863 s at IL6ST 4.00E-06 0.78 216455 at — 7.20E-05 -0.28 207704 s at GAS7 2.60E-05 0.78 215267 s at SLC8A2 7.80E-05 -0.28 214475 x at CAPN3 2.70E-05 0.78 220675 s at ADPN 8.10E-05 -0.28 36545 s at SFI1 3.00E-06 0.79 221248 s at WHSC1L1 8.10E-05 -0.28 220351 at CCRL1 3.20E-05 0.79 210422 x at SLC11A1 8.20E-05 -0.28 213030 s at PLXNA2 3.60E-05 0.79 207380 x at NOX1 8.90E-05 -0.28 221922 at GPSM2 9.20E-05 0.79 208217 at GABRR2 9.70E-05 -0.28 219573 at LRRC16 <1.00E-06 0.8 208225 at FGFR2 <1.00E-06 -0.27 219632 s at TRPV1 <1.00E-06 0.8 215448 at KCNH7 <1.00E-06 -0.27 212254 s at DST 2.00E-06 0.8 215476 at — <1.00E-06 -0.27 221565 s at FAM26B 2.00E-06 0.8 219486 at DUS2L <1.00E-06 -0.27 203788 s at SEMA3C 8.90E-05 0.8 220149 at FLJ22671 <1.00E-06 -0.27 208740 at SAP18 <1.00E-06 0.81 32699 s at PVR <1.00E-06 -0.27 211382 s at TACC2 <1.00E-06 0.81 210419 at BARX2 <1.00E-06 -0.27 213008 at FLJ10719 <1.00E-06 0.81 214635 at CLDN9 <1.00E-06 -0.27 205260 s at ACYP1 3.00E-06 0.81 216042 at TNFRSF25 <1.00E-06 -0.27 222291 at DKFZP564J102 6.00E-06 0.81 219537 x at DLL3 <1.00E-06 -0.27 74694 s at RABEP2 6.00E-06 0.81 219950 s at TIAM2 <1.00E-06 -0.27 221045 s at PER3 1.00E-05 0.81 205307 s at KMO 2.00E-06 -0.27 218663 at HCAP-G 4.20E-05 0.81 205778 at KLK7 2.00E-06 -0.27 213236 at SASH1 5.80E-05 0.81 206970 at CNTN2 2.00E-06 -0.27 202294 at STAG1 <1.00E-06 0.82 210392 x at NR6A1 2.00E-06 -0.27 212538 at DOCK9 2.00E-06 0.82 210789 x at CEACAM3 3.00E-06 -0.27 205002 at AHDC1 4.00E-06 0.82 211805 s at SLC8A1 3.00E-06 -0.27 220419 s at USP25 4.00E-06 0.82 220106 at NPC1L1 3.00E-06 -0.27 204358 s at FLRT2 5.10E-05 0.82 201265 at — 4.00E-06 -0.27 201034 at ADD3 7.70E-05 0.82 206168 at ZC3H7B 4.00E-06 -0.27 200672 x at SPTBN1 <1.00E-06 0.83 208034 s at PROZ 4.00E-06 -0.27 205658 s at SNAPC4 <1.00E-06 0.83 214824 at — 4.00E-06 -0.27 214769 at CLCN4 1.80E-05 0.83 216644 at — 4.00E-06 -0.27 200671 s at SPTBN1 <1.00E-06 0.84 208068 x at CSH1 5.00E-06 -0.27 205176 s at ITGB3BP <1.00E-06 0.84 208269 s at ADAM28 5.00E-06 -0.27 212206 s at H2AFV <1.00E-06 0.84 207902 at IL5RA 6.00E-06 -0.27 212914 at CBX7 <1.00E-06 0.84 210248 at WNT7A 9.00E-06 -0.27 218385 at MRPS18A <1.00E-06 0.84 210736 x at DTNA 9.00E-06 -0.27 211593 s at MAST2 <1.00E-06 0.84 215621 s at IGHD 1.00E-05 -0.27 218284 at SMAD3 2.00E-06 0.84 Myxoﬁbrosarcoma 15

215756 at LOC440708 1.00E-05 -0.27 214889 at DKFZP564J102 1.00E-05 0.84 220535 at FAM90A1 1.20E-05 -0.27 203217 s at ST3GAL5 1.50E-05 0.84 222268 x at MUC5B 1.20E-05 -0.27 218813 s at SH3GLB2 2.80E-05 0.84 208358 s at UGT8 1.30E-05 -0.27 218346 s at SESN1 <1.00E-06 0.85 217458 at — 1.30E-05 -0.27 218662 s at HCAP-G 3.00E-06 0.85 208063 s at CAPN9 1.50E-05 -0.27 205240 at GPSM2 <1.00E-06 0.86 208465 at GRM2 1.50E-05 -0.27 205882 x at ADD3 3.00E-06 0.86 208069 x at CSH1 1.70E-05 -0.27 217940 s at FLJ10769 9.00E-06 0.86 208367 x at CYP3A4 1.70E-05 -0.27 218503 at KIAA1797 7.20E-05 0.86 210060 at PDE6G 1.80E-05 -0.27 203358 s at EZH2 8.30E-05 0.86 32540 at PPP3CC 1.80E-05 -0.27 205824 at HSPB2 <1.00E-06 0.87 220813 at CYSLTR2 1.90E-05 -0.27 219093 at FLJ20701 3.40E-05 0.87 208535 x at COL13A1 2.00E-05 -0.27 201397 at PHGDH 5.10E-05 0.87 221390 s at MTMR8 2.10E-05 -0.27 202054 s at ALDH3A2 <1.00E-06 0.88 205014 at FGFBP1 2.30E-05 -0.27 204747 at IFIT3 4.00E-06 0.88 216687 x at UGT2B15 2.30E-05 -0.27 203690 at TUBGCP3 1.80E-05 0.88 216145 at DGCR14 2.40E-05 -0.27 219427 at FAT4 2.00E-05 0.88 206340 at NR1H4 2.50E-05 -0.27 214909 s at DDAH2 <1.00E-06 0.89 214950 at IL9R* 2.60E-05 -0.27 206653 at POLR3G 1.60E-05 0.89 207466 at GAL 2.80E-05 -0.27 204545 at PEX6 <1.00E-06 0.9 208156 x at EPPK1 2.80E-05 -0.27 205168 at DDR2 <1.00E-06 0.9 179 at PMS2L11 2.90E-05 -0.27 204072 s at 13CDNA73 <1.00E-06 0.9 220766 at BTG4 3.10E-05 -0.27 213147 at HOXA10 4.00E-06 0.9 208219 at ACVR1B 3.50E-05 -0.27 214110 s at — 1.30E-05 0.9 205313 at TCF2 4.20E-05 -0.27 212719 at PHLPP 2.40E-05 0.9 210722 at PNLIPRP1 4.30E-05 -0.27 204633 s at RPS6KA5 <1.00E-06 0.91 211918 x at PAPPA2 4.50E-05 -0.27 208611 s at SPTAN1 <1.00E-06 0.91 216497 at HNRPA1 4.70E-05 -0.27 221693 s at MRPS18A <1.00E-06 0.91 221594 at DKFZP564O0523 4.70E-05 -0.27 216033 s at FYN 6.00E-06 0.91 201884 at CEACAM5 5.80E-05 -0.27 221645 s at ZNF83 1.80E-05 0.91 208434 at MDS1 6.90E-05 -0.27 209485 s at OSBPL1A 2.40E-05 0.91 217245 at EPAG 7.00E-05 -0.27 205961 s at PSIP1 7.00E-05 0.91 206309 at LECT1 7.70E-05 -0.27 201369 s at ZFP36L2 7.70E-05 0.91 207420 at COLEC10 7.70E-05 -0.27 222116 s at TBC1D16 2.00E-06 0.92 215975 x at GK 7.90E-05 -0.27 206726 at PGDS 9.00E-06 0.92 216502 at ISG20L2 8.40E-05 -0.27 210797 s at OASL 4.90E-05 0.92 207938 at PI15 8.80E-05 -0.27 218970 s at CUTC <1.00E-06 0.93 208578 at SCN10A 8.90E-05 -0.27 204648 at NPR1 <1.00E-06 0.94 209856 x at ABI2 8.90E-05 -0.27 210829 s at SSBP2 5.00E-06 0.94 219659 at ATP8A2 9.90E-05 -0.27 202289 s at TACC2 <1.00E-06 0.95 215449 at BZRPL1 <1.00E-06 -0.26 202726 at LIG1 <1.00E-06 0.95 206195 x at GH2 <1.00E-06 -0.26 209184 s at IRS2 5.00E-06 0.97 216798 at RNH1* <1.00E-06 -0.26 214453 s at IFI44 6.20E-05 0.98 220481 at GPR75 <1.00E-06 -0.26 204415 at G1P3 4.00E-06 0.99 220827 at CACNA1C <1.00E-06 -0.26 201009 s at TXNIP 6.30E-05 0.99 208212 s at ALK 2.00E-06 -0.26 222217 s at SLC27A3 <1.00E-06 1 215880 at NAGLU 2.00E-06 -0.26 219703 at MNS1 <1.00E-06 1 216245 at IL1RN 2.00E-06 -0.26 205839 s at BZRAP1 9.00E-06 1 216643 at MGC29898 2.00E-06 -0.26 207761 s at DKFZP586A0522 2.10E-05 1 207444 at SLC22A13 3.00E-06 -0.26 202761 s at SYNE2 8.00E-06 1.01 213692 s at — 3.00E-06 -0.26 209905 at HOXA9 8.00E-06 1.01 214411 x at CTRB2 3.00E-06 -0.26 201785 at RNASE1 1.10E-05 1.01 222087 at — 3.00E-06 -0.26 211776 s at EPB41L3 2.20E-05 1.01 207206 s at ALOX12 4.00E-06 -0.26 204359 at FLRT2 3.30E-05 1.01 207313 x at KIR3DL2 4.00E-06 -0.26 209185 s at IRS2 3.50E-05 1.01 217434 at MC2R 4.00E-06 -0.26 201752 s at ADD3 <1.00E-06 1.02 206410 at NR0B2 6.00E-06 -0.26 213752 at FLJ43806 <1.00E-06 1.02 208441 at IGF1R 6.00E-06 -0.26 218883 s at MLF1IP 6.00E-06 1.02 222193 at FLJ21820 6.00E-06 -0.26 205383 s at ZBTB20 <1.00E-06 1.03 207329 at MMP8 7.00E-06 -0.26 210139 s at PMP22 7.00E-06 1.03 207780 at CYLC2 7.00E-06 -0.26 219686 at STK32B 2.00E-05 1.03 207861 at CCL22 7.00E-06 -0.26 212226 s at PPAP2B 2.50E-05 1.03 206154 at RLBP1 8.00E-06 -0.26 209355 s at PPAP2B 2.90E-05 1.03 210810 s at SLC6A5 8.00E-06 -0.26 213478 at KIAA1026 2.90E-05 1.03 211053 at KCNG1 1.00E-05 -0.26 218922 s at LASS4 <1.00E-06 1.04 215142 at CXorf27 1.00E-05 -0.26 206170 at ADRB2 1.00E-05 1.04 216293 at CLTA 1.00E-05 -0.26 202262 x at DDAH2 <1.00E-06 1.06 216909 at KIAA0690 1.00E-05 -0.26 213156 at — 4.00E-06 1.06 206728 at ECE2 1.10E-05 -0.26 200696 s at GSN 5.00E-06 1.06 210680 s at MASP1 1.30E-05 -0.26 209785 s at PLA2G4C 1.80E-05 1.06 214788 x at DDN 1.30E-05 -0.26 220955 x at RAB23 5.90E-05 1.06 206514 s at CYP4F3* 1.40E-05 -0.26 210136 at MBP 8.20E-05 1.07 213774 s at — 1.40E-05 -0.26 221841 s at KLF4 9.70E-05 1.07 216408 at OR2B2 1.40E-05 -0.26 206702 at TEK 2.10E-05 1.08 220657 at KLHL11 1.40E-05 -0.26 211067 s at GAS7 3.00E-06 1.09 Myxoﬁbrosarcoma 16

213542 at DKFZp547K1113 1.60E-05 -0.26 215303 at — <1.00E-06 1.1 211565 at SH3GL3 1.70E-05 -0.26 213523 at CCNE1 <1.00E-06 1.1 221288 at GPR22 1.70E-05 -0.26 202920 at ANK2 2.90E-05 1.1 210401 at P2RX1 2.10E-05 -0.26 204510 at CDC7 <1.00E-06 1.11 215959 at PPFIBP2 2.10E-05 -0.26 213797 at RSAD2 4.80E-05 1.11 216090 x at — 2.20E-05 -0.26 211792 s at CDKN2C <1.00E-06 1.12 219746 at DPF3 2.20E-05 -0.26 215537 x at DDAH2 <1.00E-06 1.13 206885 x at GH1 2.60E-05 -0.26 214433 s at SELENBP1 1.50E-05 1.13 215085 x at DLEC1 2.60E-05 -0.26 202765 s at FBN1 8.20E-05 1.13 215989 at CBX2 2.70E-05 -0.26 209543 s at CD34 <1.00E-06 1.14 222383 s at ALOXE3 2.80E-05 -0.26 209337 at PSIP1 3.00E-06 1.14 221119 at FLJ20184 2.90E-05 -0.26 219978 s at NUSAP1 <1.00E-06 1.15 219829 at ITGB1BP2 3.10E-05 -0.26 203126 at IMPA2 3.00E-06 1.15 214303 x at MUC5AC 3.30E-05 -0.26 206030 at ASPA 8.40E-05 1.15 218792 s at BSPRY 3.50E-05 -0.26 204162 at KNTC2 <1.00E-06 1.16 208346 at PPBPL2 3.70E-05 -0.26 203726 s at LAMA3 2.00E-06 1.16 208377 s at CACNA1F 3.90E-05 -0.26 219740 at FLJ12505 9.00E-06 1.16 208429 x at HNF4A 3.90E-05 -0.26 202191 s at GAS7 2.00E-05 1.16 203461 at CHD2 4.10E-05 -0.26 211998 at H3F3B <1.00E-06 1.18 210804 x at SLC8A1 4.20E-05 -0.26 219563 at C14orf139 5.00E-06 1.18 214888 at CAPN2 4.40E-05 -0.26 214040 s at GSN <1.00E-06 1.2 210799 at HTR1B 4.60E-05 -0.26 210882 s at TRO 2.00E-05 1.21 206944 at HTR6 4.70E-05 -0.26 205399 at DCAMKL1 <1.00E-06 1.23 211232 x at GLP1R 4.70E-05 -0.26 204070 at RARRES3 <1.00E-06 1.24 217308 at OR1F2 4.90E-05 -0.26 207808 s at PROS1 <1.00E-06 1.26 207321 s at ABCB9 5.20E-05 -0.26 213630 at KIAA0363* <1.00E-06 1.26 215738 at — 5.40E-05 -0.26 206516 at AMH 1.20E-05 1.27 208588 at FKSG2 5.60E-05 -0.26 205794 s at NOVA1 <1.00E-06 1.28 221115 s at LENEP 6.20E-05 -0.26 204471 at GAP43 7.70E-05 1.28 216481 at GRIP2 6.30E-05 -0.26 213033 s at NFIB <1.00E-06 1.3 220440 at LGALS13 6.60E-05 -0.26 205870 at BDKRB2 <1.00E-06 1.33 216482 x at ZNF79 6.80E-05 -0.26 218918 at MAN1C1 5.00E-06 1.33 217230 at VIL2 7.60E-05 -0.26 205379 at CBR3 <1.00E-06 1.34 215932 at MAGEC2 7.90E-05 -0.26 211700 s at TRO 2.30E-05 1.35 219318 x at MED31 9.10E-05 -0.26 32625 at NPR1 <1.00E-06 1.36 220558 x at TSPAN32 9.70E-05 -0.26 205345 at BARD1 <1.00E-06 1.38 220951 s at ACF 9.70E-05 -0.26 205931 s at CREB5 <1.00E-06 1.38 207047 s at CLCNKA* <1.00E-06 -0.25 202192 s at GAS7 <1.00E-06 1.39 208416 s at SPTB <1.00E-06 -0.25 203886 s at FBLN2 3.60E-05 1.39 216925 s at TAL1 <1.00E-06 -0.25 220266 s at KLF4 <1.00E-06 1.4 206326 at GRP <1.00E-06 -0.25 212327 at KIAA1102 1.30E-05 1.41 206891 at ACTN3 <1.00E-06 -0.25 220037 s at XLKD1 4.00E-05 1.45 216049 at RHOBTB3 <1.00E-06 -0.25 214890 s at DKFZP564J102 <1.00E-06 1.46 216667 at RNASE2 <1.00E-06 -0.25 213029 at NFIB <1.00E-06 1.48 217244 at — <1.00E-06 -0.25 213032 at NFIB 6.00E-06 1.5 220218 at C9orf68 <1.00E-06 -0.25 218885 s at GALNT12 4.00E-06 1.56 220636 at DNAI2 <1.00E-06 -0.25 216339 s at TNXA* <1.00E-06 1.61 220970 s at KRTAP2-4 <1.00E-06 -0.25 212328 at KIAA1102 <1.00E-06 1.61 202831 at GPX2 2.00E-06 -0.25 204731 at TGFBR3 2.00E-06 1.62 207787 at KRTHA3B 2.00E-06 -0.25 204591 at CHL1 1.90E-05 1.62 221358 at GPR8 2.00E-06 -0.25 219935 at ADAMTS5 2.60E-05 1.65 203849 s at KIF1A 3.00E-06 -0.25 214285 at FABP3 2.10E-05 1.7 215556 at — 3.00E-06 -0.25 219304 s at PDGFD <1.00E-06 1.8 215970 at ZP4 3.00E-06 -0.25 205382 s at DF 9.70E-05 1.82 208532 x at KRTAP5-8 5.00E-06 -0.25 205738 s at FABP3 1.50E-05 1.94 219365 s at CAMKV 5.00E-06 -0.25 209758 s at MFAP5 8.00E-06 2.08 219614 s at SLC6A20 5.00E-06 -0.25 200965 s at ABLIM1 <1.00E-06 2.11 220571 at PRDM11 5.00E-06 -0.25 204719 at ABCA8 3.10E-05 2.11 211493 x at DTNA 6.00E-06 -0.25 216333 x at TNXB <1.00E-06 2.16 213767 at KSR 6.00E-06 -0.25 209644 x at CDKN2A <1.00E-06 2.18 221445 at OR1A2 6.00E-06 -0.25 213764 s at MFAP5 1.20E-05 2.19 89948 at C20orf67 6.00E-06 -0.25 206093 x at TNXB <1.00E-06 2.21 221128 at ADAM19 9.00E-06 -0.25 213451 x at TNXB <1.00E-06 2.33 207211 at USP2 1.00E-05 -0.25 206742 at FIGF <1.00E-06 2.46 221323 at ULBP1 1.00E-05 -0.25 208609 s at TNXA* <1.00E-06 2.46 205470 s at KLK11 1.10E-05 -0.25 213765 at MFAP5 <1.00E-06 2.46 207280 at FLJ38628 1.10E-05 -0.25 206002 at GPR64 <1.00E-06 2.49 208323 s at ANXA13 1.20E-05 -0.25 207039 at CDKN2A <1.00E-06 2.6 207271 x at SPAG11 1.30E-05 -0.25 205200 at CLEC3B <1.00E-06 2.99 Myxoﬁbrosarcoma 17

206766 at ITGA10 3.00E-06 2.46 Y 221593 s at RPL31 0.001831 3.87 N 219371 s at KLF2 7.00E-06 0.29 N 213659 at ZNF75 0.001841 0.08 N 218451 at CDCP1 7.00E-06 2 N 209699 x at AKR1C2 0.001847 0.45 N 209287 s at CDC42EP3 7.00E-06 10.61 N 206379 at EYA3 0.001851 60.52 Y 220343 at PDE7B 8.00E-06 29.24 Y 200965 s at ABLIM1 0.001853 0.57 Y 206421 s at SERPINB7 1.30E-05 2.41 N 211483 x at CAMK2B 0.001857 5.36 Y 210139 s at PMP22 1.40E-05 0.31 Y 204992 s at PFN2 0.001905 2.79 N 205382 s at DF 1.60E-05 0.57 Y 210876 at ANXA2P1 0.001907 6.97 N 206091 at MATN3 2.10E-05 151.2 N 204080 at TOE1 0.001916 0.1 Y 209167 at GPM6B 2.20E-05 1.84 N 219417 s at FLJ20014 0.001924 0.06 N 219973 at ARSJ 2.70E-05 3.76 N 219905 at ERMAP 0.001924 0.14 Y 222234 s at MGC3101 3.40E-05 234.02 N 212230 at PPAP2B 0.001928 0.49 N 207360 s at NTSR1 4.30E-05 2.9 N 222180 at YES1 0.001934 4.6 N 213807 x at MET 4.70E-05 7.25 Y 207601 at SULT1B1 0.001953 3.97 Y 211067 s at GAS7 4.90E-05 0.32 Y 204967 at APXL 0.001962 2.12 Y 209170 s at GPM6B 5.10E-05 1.74 N 214954 at KIAA0527 0.001962 3.78 N 209286 at CDC42EP3 5.10E-05 3.31 Y 207291 at PRRG4 0.001967 10.05 N 213816 s at MET 5.20E-05 1.82 N 206298 at ARHGAP22 0.001987 2.17 N 206363 at MAF 5.80E-05 0.22 N 205281 s at PIGA 0.001988 0.04 N 211599 x at MET 6.10E-05 4.71 Y 221960 s at RAB2 0.001991 2.73 N 221841 s at KLF4 6.50E-05 0.5 Y 215760 s at KIAA0963 0.001999 0.17 N 208611 s at SPTAN1 7.00E-05 0.25 Y 209002 s at CALCOCO1 0.002003 0.12 N 219103 at DDEFL1 7.10E-05 0.18 Y 200794 x at DAZAP2 0.002024 0.16 N 206713 at NTNG1 7.20E-05 11.43 Y 203560 at GGH 0.002027 2.28 N 220266 s at KLF4 7.30E-05 0.39 Y 211037 s at LENG4 0.00203 11.95 N 206664 at SI 7.40E-05 134844608.6 N 211996 s at LOC23117 0.002033 0.37 N 203987 at FZD6 7.70E-05 2.7 N 213577 at SQLE 0.002043 4.84 Y 205199 at CA9 8.50E-05 3.01 Y 206752 s at DFFB 0.002047 0.22 N 202157 s at CUGBP2 8.90E-05 0.34 N 219633 at C20orf121 0.002058 7.24 Y 219557 s at NRIP3 9.20E-05 7.22 Y 213273 at ODZ4 0.002069 2.35 N 202947 s at GYPC 9.30E-05 0.11 Y 216156 at RECK 0.002075 970.78 N 203510 at MET 9.40E-05 1.63 N 214679 x at GNA11 0.002106 0.09 N 201061 s at STOM 9.50E-05 0.27 Y 44696 at TBC1D13 0.00212 0.07 N 206533 at CHRNA5 9.60E-05 10.6 N 200915 x at KTN1* 0.002126 4.62 N 206614 at GDF5 9.90E-05 8.64 Y 219278 at MAP3K6 0.002128 0.23 Y 219970 at GIPC2 0.000107 2.32 N 209679 s at LOC57228 0.002135 2.39 N 209288 s at CDC42EP3 0.000112 3.02 N 207501 s at FGF12 0.002189 7.58 N 219963 at DUSP13 0.000112 16.86 N 202291 s at MGP 0.002219 0.58 N 200785 s at LRP1 0.000115 0.15 N 219031 s at CGI-37 0.002241 9.04 Y 204032 at BCAR3 0.000118 8.37 N 210201 x at BIN1 0.002245 0.4 Y 215856 at CD33L3 0.000121 2.38 N 203904 x at CD82 0.002248 3.84 N 216493 s at IMP-3 0.000125 11.38 N 202931 x at BIN1 0.002258 0.38 Y 204359 at FLRT2 0.00013 0.36 Y 220123 at SLC35F5 0.00229 231.8 N 34206 at CENTD2 0.000132 0.12 N 203445 s at CTDSP2 0.002306 0.12 N 209803 s at PHLDA2 0.000137 1.97 N 206156 at GJB5 0.002309 44.43 N 208413 at RARB 0.00014 4453.22 N 205331 s at C5orf19 0.00231 32.7 N 204729 s at STX1A 0.00014 4.17 Y 212041 at ATP6V0D1 0.002319 0.21 N 209169 at GPM6B 0.000144 2.5 N 219260 s at DERP6 0.002322 1.99 N 203886 s at FBLN2 0.000152 0.47 Y 220910 at FRAS1 0.002323 4.71 N 211896 s at DCN 0.000158 0.32 N 216910 at XPNPEP2 0.002335 0.44 N 201126 s at MGAT1 0.000158 0.13 N 209301 at CA2 0.002347 1.73 N 213089 at LOC153561 0.00016 0.32 N 209535 s at — 0.002353 4.55 N 203384 s at GOLGA1 0.000162 0.15 Y 218627 at FLJ11259 0.002361 0.48 N 206137 at RIMS2 0.000166 76.13 Y 221902 at GPR153 0.002372 0.32 N 204140 at TPST1 0.000167 0.18 N 221747 at TNS 0.002373 0.34 Y 209216 at WDR45 0.000167 0.13 N 212923 s at C6orf145 0.002375 0.17 N 202254 at SIPA1L1 0.000169 4.04 N 220473 s at ZCCHC4 0.002381 71.35 N 204337 at RGS4 0.00017 1.86 Y 219232 s at EGLN3 0.002388 4.15 Y 203767 s at STS 0.000182 0.27 N 214236 at CDC27 0.002397 16.08 N 206581 at BNC1 0.000188 15.39 Y 204731 at TGFBR3 0.002403 0.6 Y 205372 at PLAG1 0.000194 1.87 N 221584 s at KCNMA1 0.002408 2 N 207704 s at GAS7 0.000197 0.18 Y 201964 at ALS4 0.002415 0.23 Y 215235 at SPTAN1 0.000198 0.3 Y 202053 s at ALDH3A2 0.002429 0.22 Y 219935 at ADAMTS5 2.00E-04 0.56 Y 219665 at NUDT18 0.002435 0.07 N 213338 at RIS1 0.000201 1.56 Y 219832 s at HOXC13 0.002448 23.3 Y 209217 s at WDR45 0.000215 0.11 N 219746 at DPF3 0.002448 14.26 Y 218843 at FNDC4 0.000217 3.71 N 203010 at STAT5A 0.002474 0.09 N 214053 at ERBB4 0.000219 4.41 Y 219888 at SPAG4 0.002487 2.73 Y Myxoﬁbrosarcoma 18

208562 s at ABCC9 0.000227 8.16 N 201863 at FAM32A 0.002499 0.1 N 219926 at POPDC3 0.000242 2.22 Y 202481 at DHRS3 0.00252 0.39 N 218486 at KLF11 0.000245 0.14 N 202155 s at NUP214 0.00253 0.12 N 215129 at PIK3C2G 0.000252 6.51 Y 201635 s at FXR1 0.002534 5.39 N 202054 s at ALDH3A2 0.000256 0.23 Y 204022 at WWP2 0.002561 0.17 N 208378 x at FGF5 0.000256 3.81 Y 216884 at PTPN12 0.002583 16.31 N 219094 at ARMC8 0.000259 17.2 N 213721 at SOX2 0.002593 3.73 N 202766 s at FBN1 0.000279 0.46 N 202168 at TAF9 0.002612 3.75 N 216624 s at MLL 0.000279 192.56 N 201818 at FLJ12443 0.002614 0.14 N 202510 s at TNFAIP2 0.000283 0.32 N 210675 s at PTPRR 0.002616 3.23 N 218644 at PLEK2 0.000286 7.09 Y 209629 s at NXT2 0.002625 2.64 N 57715 at FAM26B 0.000288 0.31 Y 209354 at TNFRSF14 0.002628 0.23 N 209890 at TSPAN5 0.000292 2.5 Y 215574 at — 0.002636 2.87 Y 202192 s at GAS7 0.000294 0.4 Y 200696 s at GSN 0.00264 0.42 Y 201749 at ECE1 0.000296 0.17 Y 221268 s at SGPP1 0.002643 9.27 N 215163 at — 3.00E-04 3.53 N 209218 at SQLE 0.00265 2.17 Y 211813 x at DCN 0.000306 0.37 N 212268 at SERPINB1 0.00266 0.2 N 209099 x at JAG1 0.000314 0.32 N 203811 s at DNAJB4 0.002678 2.27 N 203718 at NTE 0.000318 0.14 N 219610 at RGNEF 0.002686 6.78 Y 210872 x at GAS7 0.000322 0.15 N 216604 s at SLC7A8 0.002688 3.15 Y 218847 at IMP-2 0.000335 1.84 N 216280 s at DICER1 0.002698 73.01 N 201893 x at DCN 0.000337 0.27 N 207729 at CDH9 0.0027 3.67 N 217998 at PHLDA1 0.000343 15.51 Y 212810 s at SLC1A4 0.002705 0.3 N 211383 s at WDR37 0.000344 0.1 N 41160 at MBD3 0.002736 0.22 N 205070 at ING3 0.000345 0.15 N 210138 at RGS20 0.002743 2.34 N 218899 s at BAALC 0.000346 1.75 N 218814 s at C1orf75 0.002748 7.37 Y 205677 s at DLEU1 0.000346 4.32 Y 209645 s at ALDH1B1 0.002756 2.52 N 206633 at CHRNA1 0.00035 2.22 N 218110 at XAB2 0.002767 0.35 Y 206566 at SLC7A1 0.000357 17.9 N 202112 at VWF 0.002776 0.44 N 206429 at F2RL1 0.000368 3.16 Y 219522 at FJX1 0.002778 2.58 N 215853 at SDCCAG8 0.000369 158.78 N 219717 at FLJ20280 0.002788 3.47 N 208782 at FSTL1 0.00037 0.22 Y 208075 s at CCL7 0.002838 4.33 N 205294 at BAIAP2 0.000376 8.07 N 212714 at LARP4 0.002839 0.22 N 218205 s at MKNK2 0.000381 0.19 N 209347 s at MAF 0.002844 0.14 N 202156 s at CUGBP2 0.000404 0.35 N 207022 s at LDHC 0.002859 7.78 N 222038 s at CGI-48 0.000406 7.01 N 213605 s at C6orf216 0.002896 0.34 N 209168 at GPM6B 0.000411 2.2 N 217061 s at ETV1 0.002906 4.84 N 212670 at ELN 0.000421 0.57 N 220664 at SPRR2C 0.002914 0 N 220815 at CTNNA3 0.000424 5.76 Y 211553 x at APAF1 0.002931 101.03 N 208747 s at C1S 0.000429 0.47 N 212914 at CBX7 0.002938 0.37 Y 207329 at MMP8 0.000433 26.06 Y 210755 at HGF 0.002958 1.65 N 220739 s at CNNM3 0.000434 0.14 Y 208561 at ABCC9 0.002967 3.31 N 203853 s at GAB2 0.000447 0.16 N 213038 at IBRDC3 0.003005 0.35 N 202951 at STK38 0.000449 0.21 N 205399 at DCAMKL1 0.003008 0.39 Y 220613 s at SYTL2 0.000449 5.43 N 201870 at TOMM34 0.003016 4.96 Y 213907 at EEF1E1 0.000455 9.88 N 204151 x at AKR1C1 0.003025 0.51 N 206474 at PCTK2 0.000465 26.71 N 209605 at TST 0.003027 0.31 N 216740 at TRERF1 0.000471 5835.72 N 209541 at IGF1 0.003034 0.43 N 205081 at CRIP1 0.000488 0.51 N 201789 at DHRS7 0.003035 12.65 N 212423 at C10orf56 0.000504 0.28 N 218415 at VPS33B 0.003049 0.06 N 219952 s at MCOLN1 0.000507 0.18 Y 218368 s at TNFRSF12A 0.003067 2.22 N 205918 at SLC4A3 0.000511 8.77 Y 215096 s at ESD 0.003097 2.71 N 209335 at DCN 0.000518 0.36 N 214837 at ALB 0.003101 237526.59 N 208609 s at TNXA* 0.000524 0.62 Y 203936 s at MMP9 0.003103 1.41 N 221656 s at ARHGEF10L 0.000546 0.15 Y 218547 at DHDDS 0.003119 0.04 N 212419 at C10orf56 0.000547 0.26 Y 217383 at PGK1 0.003145 3.97 N 206127 at ELK3 0.000559 5.35 Y 219566 at PLEKHF1 0.003162 0.26 Y 222245 s at FER1L4 0.000567 3.79 Y 201155 s at MFN2 0.003169 0.14 Y 217316 at OR7A10 0.00057 549.92 N 219682 s at TBX3 0.003178 2.44 N 221458 at HTR1F 0.000582 4.69 Y 220765 s at LIMS2 0.00318 0.23 N 212067 s at C1R 0.000592 0.44 N 209689 at FLJ10996 0.003187 0.14 Y 204512 at HIVEP1 0.000595 0.32 N 217849 s at CDC42BPB 0.003188 0.33 N 216450 x at TRA1 0.000597 3.3 N 220698 at MGC4294 0.0032 2.27 N 207761 s at DKFZP586A0522 0.000603 0.41 Y 214265 at ITGA8 0.003216 2.87 Y 212457 at TFE3 0.000607 0.09 N 210165 at DNASE1 0.003262 26.3 N 215452 x at SUMO4 0.000617 11.81 N 204120 s at ADK 0.003288 5.14 N 213793 s at HOMER1 0.000618 2.54 N 213244 at SCAMP4 0.003297 0.25 N 211039 at CHRNA1 0.000623 9.01 Y 209688 s at FLJ10996 0.003316 0.39 Y 201508 at IGFBP4 0.000654 0.37 N 200784 s at LRP1 0.003318 0.14 N 217208 s at DLG1 0.000661 3.3 N 212574 x at C19orf6 0.003324 0.35 N 219263 at RNF128 0.000664 2.46 N 204538 x at NPIP 0.003332 0.3 Y 213506 at F2RL1 0.00067 1.69 N 209912 s at KIAA0415 0.003334 0.27 N 218845 at DUSP22 0.000676 0.15 Y 210075 at MARCH2 0.003344 0.36 N 201957 at PPP1R12B 0.000678 0.05 N 221319 at PCDHB8 0.003418 100.32 N 202166 s at PPP1R2 0.000684 2.98 N 212323 s at VPS13D 0.003435 0.07 Y Myxoﬁbrosarcoma 19

205453 at HOXB2 0.000685 4.16 Y 213850 s at SFRS2IP 0.003456 0.17 N 219368 at NAP1L2 0.000706 1.94 N 218749 s at SLC24A6 0.00346 0.06 N 206408 at LRRTM2 0.000717 19.99 N 200753 x at SFRS2 0.003461 5.87 N 207049 at SCN8A 0.000725 17.42 N 202091 at ARL2BP 0.003469 20.11 N 204612 at PKIA 0.000734 2.53 N 32502 at GDPD5 0.003481 0.27 N 209990 s at GPR51 0.000748 3.13 N 214439 x at BIN1 0.003486 0.4 Y 202073 at OPTN 0.000771 0.36 N 207147 at DLX2 0.003508 3.45 N 208422 at MSR1 0.000772 17.07 N 204402 at C22orf3 0.003515 0.19 N 216333 x at TNXB 0.000781 0.62 Y 219638 at FBXO22 0.003521 28.74 Y 205253 at PBX1 0.000784 0.29 N 216594 x at AKR1C1 0.003537 0.42 N 213451 x at TNXB 0.000795 0.65 Y 215356 at ECAT8 0.003552 4.28 N 206074 s at HMGA1 8.00E-04 1.75 N 212148 at PBX1 0.003555 0.58 N 203119 at MGC2574 0.000805 3.71 Y 210946 at PPAP2A 0.003584 0.4 N 208460 at GJA7 0.000806 4.63 N 222044 at C20orf67 0.003593 5.71 Y 212678 at NF1 0.00082 0.29 N 214772 at C11orf41 0.003595 3.11 N 212505 s at KIAA0892 0.000825 0.12 N 220153 at ENTPD7 0.003601 4.95 N 220588 at BCAS4 0.000836 8.38 Y 217914 at TPCN1 0.003624 0.26 N 211393 at ZNF278 0.000862 72.77 Y 214091 s at GPX3 0.003633 0.6 N 214037 s at CCDC22 0.000875 0.1 N 222236 s at DDEFL1 0.003669 0.19 Y 221327 s at OPN1MW* 0.000906 233.82 N 207111 at EMR1 0.003675 2.1 N 207463 x at PRSS3 0.000909 2.4 N 201895 at ARAF 0.003683 0.09 N 219229 at SLCO3A1 0.000922 0.38 N 215231 at PRKAG2 0.003685 0 N 1255 g at GUCA1A 0.000926 1764.71 N 216269 s at ELN 0.003709 0.16 N 213001 at ANGPTL2 0.000935 0.34 N 215764 x at AP2A2 0.003717 0.09 N 206016 at CCDC22 0.000937 0.32 Y 220441 at FLJ13236 0.003727 5.19 Y 215537 x at DDAH2 0.000941 0.29 Y 211653 x at AKR1C2 0.003737 0.5 N 221073 s at CARD4 0.000952 0.1 N 218328 at COQ4 0.003745 0.18 N 217767 at C3 0.000953 0.62 N 201521 s at NCBP2 0.003748 4.11 N 204338 s at RGS4 0.000963 2.34 Y 203958 s at ZBTB40 0.003755 0.06 N 202790 at CLDN7 0.000963 4.08 N 205559 s at PCSK5 0.003756 0.57 N 216470 x at PRSS1 0.000975 10.1 N 219642 s at PEX5L 0.003774 12.31 N 211402 x at NR6A1 0.000976 37.11 Y 221725 at WASF2 0.003789 0.3 Y 205402 x at PRSS2 0.000976 6.15 Y 215147 at CUGBP2 0.003822 0.25 N 221743 at CUGBP1 0.000997 9.36 N 201348 at GPX3 0.003827 0.58 N 206307 s at FOXD1 0.000997 3.67 N 206484 s at XPNPEP2 0.003834 0.41 N 204211 x at EIF2AK2 0.001009 16.41 N 216033 s at FYN 0.003837 0.44 Y 200766 at CTSD 0.001012 0.3 N 206848 at HOXA7 0.00384 5.52 N 214397 at MBD2 0.001017 131.3 Y 202082 s at SEC14L1 0.003845 2.91 N 221790 s at LDLRAP1 0.00102 0.06 N 219615 s at KCNK5 0.003862 0.07 N 206173 x at GABPB2 0.00102 9.55 N 210747 at HLA-DQB1 0.003874 34.62 N 210997 at HGF 0.001026 1.55 N 212854 x at DJ328E19.C1.1 0.003878 0.21 Y 203069 at SV2A 0.001033 2.17 N 203556 at ZHX2 0.003883 0.33 N 201742 x at SFRS1 0.001036 4.78 N 212518 at PIP5K1C 0.003885 0.18 N 212516 at CENTD2 0.001049 0.13 N 214632 at NRP2 0.00389 2.9 N 221310 at FGF14 0.00105 11.6 N 221266 s at TM7SF4 0.003893 3.53 Y 202765 s at FBN1 0.001052 0.55 Y 205330 at MN1 0.003906 0.47 N 208511 at PTTG3 0.001053 6.13 N 215148 s at APBA3 0.00391 0.25 N 211950 at RBAF600 0.001058 0.3 Y 209106 at NCOA1 0.003926 0.23 Y 216592 at MAGEC3 0.001058 11.43 N 49452 at ACACB 0.003929 0.21 N 204339 s at RGS4 0.001068 2.86 Y 209575 at IL10RB 0.003944 0.13 N 204943 at ADAM12 0.001071 10.29 Y 220690 s at DKFZp566O084 0.003973 0.23 N 215298 at — 0.001073 71.88 N 218796 at C20orf42 0.00399 2.32 Y 221565 s at FAM26B 0.001078 0.3 Y 208701 at APLP2 0.003992 7.5 N 221773 at ELK3 0.001082 2.66 Y 215926 x at SNAPC4 0.003999 0.2 Y 204214 s at RAB32 0.001094 0.35 Y 220534 at TRIM48 0.004022 65.78 N 220523 at EFHC2 0.001098 476.16 Y 206432 at HAS2 0.004024 1.54 N 203508 at TNFRSF1B 0.001104 0.42 N 208919 s at NADK 0.004044 0.25 N 204789 at FMNL1 0.001113 0.27 N 217129 at — 0.004044 60.05 Y 213585 s at PDCD2 0.001115 125.4 N 208971 at UROD 0.004046 0.13 Y 200994 at IPO7 0.001127 2.59 Y 216149 at DKFZp667M2411 0.004046 14.95 Y 206093 x at TNXB 0.00113 0.62 Y 208626 s at VAT1 0.004059 0.28 N 210124 x at SEMA4F 0.001152 4.01 Y 208600 s at GPR39 0.004065 6.25 N 216268 s at JAG1 0.001153 0.37 N 207020 at HSF2BP 0.004069 10.61 Y 201997 s at SPEN 0.001162 0.08 N 205957 at PLXNB3 0.004092 2.98 Y 218632 at HECTD3 0.001164 0.11 N 215727 x at MGC3040 0.004101 17.95 N 214909 s at DDAH2 0.001171 0.21 Y 213986 s at C19orf6 0.004118 0.29 N 214161 at C8orf1 0.001173 98.53 Y 210136 at MBP 0.004119 0.49 Y 214702 at FN1 0.001185 1.82 N 213421 x at PRSS3 0.004126 2.21 N 215252 at DNAJC7 0.001192 7.29 N 201118 at PGD 0.004128 0.35 N 206373 at ZIC1 0.001196 1.87 N 210125 s at BANF1 0.004128 6.31 N 205450 at PHKA1 0.001197 6.66 N 219488 at A4GALT 0.004132 0.21 N 218262 at FLJ22318 0.001209 0.14 N 209062 x at NCOA3 0.004133 6.93 Y 217979 at TM4SF13 0.001223 2.03 N 213879 at SUMO2 0.004151 9.25 N 217136 at PPIAL4 0.001224 9909.84 N 202151 s at UBADC1 0.004152 0.2 Y 202920 at ANK2 0.001227 0.47 Y 215637 at TSGA14 0.004155 396.36 N Myxoﬁbrosarcoma 20

214761 at ZNF423 0.00123 0.53 N 206732 at SLITRK3 0.004166 12.81 N 205658 s at SNAPC4 0.001231 0.25 Y 220851 at — 0.004181 32.05 Y 203007 x at LYPLA1 0.001239 3.43 N 205832 at CPA4 0.004236 6.59 Y 206742 at FIGF 0.001241 0.51 Y 203999 at SYT1 0.004236 1.83 Y 201369 s at ZFP36L2 0.001251 0.5 Y 206284 x at CLTB 0.004247 0.35 Y 200829 x at ZNF207 0.001258 23.3 N 202734 at TRIP10 0.00426 0.3 N 215717 s at FBN2 0.001261 2.08 N 218502 s at TRPS1 0.00427 1.73 N 204784 s at MLF1 0.001265 3.16 N 201278 at DAB2 0.004272 0.44 N 214362 at RGS12 0.001268 5491.54 N 206504 at CYP24A1 0.004297 5.47 N 205389 s at ANK1 0.001302 8.26 N 217691 x at SLC16A3 0.00431 5.37 N 204783 at MLF1 0.001327 6.12 N 202787 s at MAPKAPK3 0.004315 7.96 N 203776 at GPKOW 0.00133 0.07 N 212246 at MCFD2 0.004327 2.32 N 214866 at PLAUR 0.001331 4.14 Y 215699 x at SFI1 0.004368 0.11 N 208077 at C9orf38 0.00134 6.91 N 212010 s at H41 0.004369 0.19 N 213343 s at GDPD5 0.001345 0.19 N 220757 s at UBXD1 0.004399 0.18 N 202158 s at CUGBP2 0.001352 0.44 N 218639 s at ZXDC 0.004401 0.14 Y 205073 at CYP2J2 0.001354 9.51 Y 214334 x at DAZAP2* 0.004406 0.13 N 214277 at COX11* 0.001356 11379.04 N 208683 at CAPN2 0.004447 5.07 N 220014 at LOC51334 0.001359 1.55 N 210907 s at PDCD10 0.004458 4.47 N 204096 s at ELL 0.00136 0.04 N 201728 s at KIAA0100 0.004474 3.05 N 205146 x at APBA3 0.001366 0.24 N 202914 s at ARHGEF11 0.004478 0.07 N 203819 s at IMP-3 0.001376 1.73 N 203236 s at LGALS9 0.004508 0.31 N 204221 x at GLIPR1 0.001383 3.04 N 217761 at MTCBP-1 0.004526 0.43 N 219231 at NCOA6IP 0.001385 4.96 N 208706 s at EIF5 0.004532 0.23 N 209348 s at MAF 0.001395 0.42 N 217937 s at HDAC7A 0.004534 0.15 Y 218031 s at CHES1 0.001409 0.33 Y 51200 at FLJ20850 0.00455 0.42 Y 212623 at TMEM41B 0.001419 4.07 N 205518 s at CMAH 0.004557 0.42 N 210367 s at PTGES 0.001424 0.41 N 44673 at SN 0.004558 0.4 N 219994 at APBB1IP 0.001425 0.17 Y 217996 at PHLDA1 0.004566 1.79 N 202191 s at GAS7 0.001429 0.51 Y 209160 at AKR1C3 0.004567 0.61 N 211390 at CG018 0.001429 301.71 N 210404 x at CAMK2B 0.004567 5.4 N 219308 s at AK5 0.001447 3.36 N 214345 at — 0.004584 23.19 N 216895 at GABRG3 0.001448 113.27 Y 205620 at F10 0.004592 0.21 N 207800 at AKAP5 0.001452 145.32 N 210098 s at — 0.004604 4.04 N 208025 s at HMGA2 0.001458 1.49 Y 218587 s at MDSRP 0.004606 0.24 Y 207633 s at MUSK 0.001461 1138.53 Y 218476 at POMT1 0.004614 0.27 Y 209960 at HGF 0.001462 1.7 N 209656 s at TMEM47 0.004623 0.58 N 209239 at NFKB1 0.001464 0.22 N 217772 s at MTCH2 0.004655 5.98 N 220334 at RGS17 0.001467 2.28 N 217266 at RPL15 0.004659 2.78 Y 218648 at TORC3 0.001476 0.11 N 201648 at JAK1 0.004661 0.16 N 202074 s at OPTN 0.001483 0.32 N 219095 at PLA2G4B 0.004667 0.16 N 203546 at IPO13 0.00149 0.03 N 215145 s at CNTNAP2 0.004668 4.66 N 206060 s at PTPN22 0.001495 5.59 N 209991 x at GPR51 0.00467 14.78 N 212226 s at PPAP2B 0.001512 0.51 Y 203950 s at CLCN6 0.004671 0.21 Y 205385 at MDM2 0.001513 53.16 N 204782 at — 0.004678 7.57 Y 209355 s at PPAP2B 0.001516 0.5 Y 219298 at ECHDC3 0.004678 2.94 N 201741 x at SFRS1 0.001517 12.06 N 218288 s at MDS025 0.004692 3.22 N 202262 x at DDAH2 0.001526 0.29 Y 210091 s at DTNA 0.004697 48.1 N 217077 s at GPR51 0.001564 8.03 Y 209098 s at JAG1 0.004709 0.31 N 202666 s at ACTL6A 0.001568 4.15 Y 36554 at ASMTL 0.004712 0.32 Y 216339 s at TNXA* 0.001573 0.44 Y 214841 at CNIH3 0.004723 1.92 N 214940 s at C17orf31 0.00159 0.17 Y 217632 at — 0.004735 114.27 N 205032 at ITGA2 0.001593 7.03 Y 211423 s at SC5DL 0.004737 3.99 N 216275 at BUB1 0.001596 61.93 Y 213139 at SNAI2 0.004786 1.97 N 209147 s at PPAP2A 0.001602 0.42 N 215375 x at LRRFIP1 0.004795 2.82 N 212326 at VPS13D 0.001607 0.17 Y 206378 at SCGB2A2 0.004804 964.09 N 203093 s at TIMM44 0.001623 0.07 Y 201924 at AFF1 0.004821 0.34 N 207545 s at NUMB 0.001636 6.63 N 212684 at ZNF3 0.004835 0.14 N 204206 at MNT 0.00165 0.12 N 211189 x at CD84 0.00484 5.66 Y 204259 at MMP7 0.001656 8.27 N 204908 s at BCL3 0.004859 0.33 N 205022 s at CHES1 0.001657 0.34 N 203721 s at WDR50 0.004863 3.9 N 218918 at MAN1C1 0.001665 0.52 Y 215721 at IGHG1 0.00487 577.91 N 212009 s at STIP1 0.001684 4.31 N 210687 at CPT1A 0.004877 0 N 219367 s at NRP2 0.001689 5.6 Y 203409 at DDB2* 0.004885 3.09 N 201106 at GPX4 0.001692 0.26 N 220180 at SE57-1 0.004889 2.72 N 210733 at — 0.001704 4.78 Y 60474 at C20orf42 0.00489 2.49 N 201883 s at B4GALT1 0.001706 0.25 N 209277 at TFPI2 0.004896 1.67 N 205419 at EBI2 0.001715 3.11 N 210682 at LPO 0.004909 12.11 Y 220608 s at — 0.001716 16.34 N 204039 at CEBPA 0.004914 0.31 N 202677 at RASA1 0.001727 6.95 N 212356 at KIAA0323 0.004915 0.13 N 218931 at RAB17 0.001738 19.59 N 214992 s at DNASE2 0.004938 0.15 N 219093 at FLJ20701 0.001749 0.32 Y 217120 s at CRSP2 0.004939 6.3 Y 201474 s at ITGA3 0.001753 2.65 N 204537 s at GABRE 0.004945 0.59 N 37796 at LRCH4 0.001762 0.08 N 215241 at TMEM16C 0.004956 3.31 N 210457 x at HMGA1 0.00178 5.62 N 201862 s at LRRFIP1 0.00496 2.72 N Myxoﬁbrosarcoma 21

201965 s at ALS4 0.00179 0.12 Y 213765 at MFAP5 0.004993 0.72 Y 219934 s at SULT1E1 0.00181 9.8 Y 202724 s at FOXO1A 0.004999 0.32 N Myxoﬁbrosarcoma 22

Module Number Genes ID of Genes 0 19 FIGF FYN PLAUR BCAR1* MAG* CRK* MET ITGA10 WASF2 PMP22 ITGB1* ITGA2 ITGA6* PPAP2B ITGA8 BIN1 BUB1 ITGB4* FN1* 1 2 HOXB2 SOD1*

2 13 ACAN* BCAN* ADAMTS5 GDF5 TGFBR3 CTGF* ACVR2A* FBLN2 HSPG2* FBN1 MFAP5 MMP8 FBN2* 3 5 ERBB4 SNTB2* ABLIM1 DTNA KCNJ12*

4 2 CIITA* ZXDC

5 10 GAS7 SPTAN1 GSN ERMAP EVL* CTNNA1* APBB1IP CA9 VASP* ACTA1*

6 2 ANK1* SLC4A3

7 21 NR4A1* THRB* PRMT1* DDX5* DDX17* RARG* DRAP1* GTF2B* RARB NR1I2* ESRRA* RXRB* NCOA1 CAMK2B PPARG* NCOA3 NCOR2* ARHGEF10L PSMB9* TAF9 MBP

8 3 LRRFIP1 ACTL6A FLII*

9 3 CAPN2 F2RL1 NMT1*

10 2 NRP2 SEMA4F

11 10 RIMS1* SYT4* WWP2 SCNN1B* SCNN1A* SCNN1G* UNC13B* ABCC9 STX1A SYT1

12 3 MBD2 SPEN MBD3*

13 5 ABCF3* SULT1E1 EEF1A1* DLEU1 TOE1

14 2 SH2D1A* CD84 Category Term Count % PVal Genes List Pop Pop Fold Benja- FDR Total Hits Total Enrichm mini

Module 0

KEGG.PATHWAY hsa04510:Focal adhesion 12 63.2 1.03E-12 ITGA6, FYN, ITGA8, BCAR1, MET, ITGB4, ITGA10 17 201 5085 17.9 4.44E-11 9.61E-10 ITGA2, CRK, FIGF, ITGB1, FN1 GOTERM.BP.FAT GO:0007229 integrin-mediated signaling pathway 7 36.8 2.73E-10 ITGA6, ITGA8, BCAR1, ITGB4, ITGA10, ITGA2, ITGB1 19 70 13528 71.2 1.16E-07 3.84E-07 SP.PIR.KEYWORDS integrin 6 31.6 2.87E-10 ITGA6, ITGA8, ITGB4, ITGA10, ITGA2, ITGB1 19 41 19235 148.2 2.73E-08 3.15E-07 GOTERM.CC.FAT GO:0008305 integrin complex 6 31.6 3.51E-10 ITGA6, ITGA8, ITGB4, ITGA10, ITGA2, ITGB1 19 29 12782 139.2 4.46E-08 4.07E-07 GOTERM.BP.FAT GO:0007160 cell-matrix adhesion 7 36.8 1.19E-09 ITGA6, ITGA8, ITGB4, ITGA10, ITGA2, ITGB1, FN1 19 89 13528 56.0 2.54E-07 1.68E-06

Module 2

SP.PIR.KEYWORDS extracellular matrix 10 76.9 1.39E-15 CTGF, FBLN2, FBN1, MMP8, ACAN, HSPG2, BCAN 13 241 19235 61.4 8.80E-14 1.45E-12 FBN2, MFAP5, ADAMTS5 GOTERM.CC.FAT GO:0005578 proteinaceous extracellular matrix 10 76.9 7.12E-13 CTGF, FBLN2, FBN1, MMP8, ACAN, HSPG2, BCAN 13 320 12782 30.7 2.71E-11 6.43E-10 FBN2, MFAP5, ADAMTS5 GOTERM.CC.FAT GO:0031012 extracellular matrix 10 76.9 1.41E-12 CTGF, FBLN2, FBN1, MMP8, ACAN, HSPG2, BCAN 13 345 12782 28.5 2.67E-11 1.27E-09 FBN2, MFAP5, ADAMTS5 GOTERM.CC.FAT GO:0044421 extracellular region part 12 92.3 4.55E-12 CTGF, FBLN2, FBN1, GDF5, MMP8, ACAN, HSPG2 13 960 12782 12.3 5.76E-11 4.11E-09 TGFBR3, BCAN, FBN2, MFAP5, ADAMTS5 SP.PIR.KEYWORDS Secreted 12 92.3 2.56E-11 CTGF, FBLN2, FBN1, GDF5, MMP8, ACAN, HSPG2 13 1689 19235 10.5 7.82E-10 2.58E-08 TGFBR3, BCAN, FBN2, MFAP5, ADAMTS5

Module 3

GOTERM.CC.FAT GO:0045202 synapse 3 6.4 0.004 ERBB4, SNTB2, DTNA 5 355 12782 21.6 0.14 3.82 UP.SEQ.FEATURE short sequence motif:PDZ-binding 2 4.3 0.016 ERBB4, KCNJ12 5 75 19113 101.9 0.44 13.17 GOTERM.CC.FAT GO:0044459 plasma membrane part 4 8.5 0.018 ERBB4, SNTB2, KCNJ12, DTNA 5 2203 12782 4.6 0.26 14.52 SP.PIR.KEYWORDS phosphoprotein 5 10.6 0.020 ABLIM1, ERBB4, SNTB2, KCNJ12, DTNA 5 7263 19235 2.6 0.55 17.03 GOTERM.BP.FAT GO:0006936 muscle contraction 2 4.3 0.034 KCNJ12, DTNA 4 153 13528 44.2 0.95 30.84

Module 5

GOTERM.MF.FAT GO:0008092 cytoskeletal protein binding 7 70.0 2.25E-08 ACTA1, GSN, EVL, CTNNA1, GAS7, VASP, SPTAN1 8 504 12983 22.5 7.65E-07 1.98E-05 SP.PIR.KEYWORDS cytoskeleton 7 70.0 9.85E-08 ACTA1, GSN, EVL, CTNNA1, APBB1IP, VASP, SPTAN1 10 636 19235 21.2 4.93E-06 9.49E-05 GOTERM.CC.FAT GO:0015629 actin cytoskeleton 6 60.0 4.68E-07 ACTA1, GSN, CTNNA1, GAS7, VASP, SPTAN1 10 269 12782 28.5 2.95E-05 4.74E-04 GOTERM.CC.FAT GO:0031252 cell leading edge 5 50.0 1.57E-06 GSN, EVL, GAS7, APBB1IP, VASP 10 138 12782 46.3 4.95E-05 0.002 GOTERM.CC.FAT GO:0005912 adherens junction 5 50.0 2.50E-06 EVL, CTNNA1, APBB1IP, VASP, SPTAN1 10 155 12782 41.2 5.25E-05 0.003

Module 7

UP.SEQ.FEATURE zinc ﬁnger region:NR C4-type 8 38.1 1.87E-14 ESRRA, RARG, NR1I2, THRB, RXRB, PPARG, NR4A1, RARB 21 45 19113 161.8 1.68E-12 2.03E-11 UP.SEQ.FEATURE DNA-binding region:Nuclear receptor 8 38.1 1.87E-14 ESRRA, RARG, NR1I2, THRB, RXRB, PPARG, NR4A1, RARB 21 45 19113 161.8 1.68E-12 2.03E-11 INTERPRO IPR001628:Zinc ﬁnger, 8 38.1 3.73E-14 ESRRA, RARG, NR1I2, THRB, RXRB, PPARG, NR4A1, RARB 20 46 16659 144.9 2.13E-12 3.70E-11 nuclear hormone receptor-type INTERPRO IPR001723:Steroid hormone receptor 8 38.1 4.37E-14 ESRRA, RARG, NR1I2, THRB, RXRB, PPARG, NR4A1, RARB 20 47 16659 141.8 1.25E-12 4.34E-11 INTERPRO IPR000536:Nuclear hormone receptor, 8 38.1 5.13E-14 ESRRA, RARG, NR1I2, THRB, RXRB, PPARG, NR4A1, RARB 20 48 16659 138.8 9.75E-13 5.08E-11 ligand-binding, core

Module 11

GOTERM.BP.FAT GO:0046903 secretion 8 80.0 8.53E-11 SYT1, STX1A, SYT4, SCNN1G, SCNN1B, UNC13B 10 300 13528 36.1 1.19E-08 1.01E-07 RIMS1, SCNN1A GOTERM.BP.FAT GO:0007269 neurotransmitter secretion 5 50.0 4.15E-09 SYT1, STX1A, SYT4, UNC13B, RIMS1 10 34 13528 198.9 2.89E-07 4.89E-06 GOTERM.BP.FAT GO:0001505 regulation of neurotransmitter levels 5 50.0 6.80E-08 SYT1, STX1A, SYT4, UNC13B, RIMS1 10 67 13528 101.0 3.15E-06 8.01E-05 GOTERM.BP.FAT GO:0006836 neurotransmitter transport 5 50.0 1.62E-07 SYT1, STX1A, SYT4, UNC13B, RIMS1 10 83 13528 81.5 5.63E-06 1.91E-04 GOTERM.BP.FAT GO:0003001 generation of a signal 5 50.0 1.79E-07 SYT1, STX1A, SYT4, UNC13B, RIMS1 10 85 13528 79.6 4.96E-06 2.10E-04 involved in cell-cell signaling

Module 13

No Signiﬁcance Table S6. Antibodies

Specificity Source β-actin Cell Signaling (#4970) AKT (total) Cell Signaling (#4691) cleaved caspase 3 Cell Signaling (#9661) cleaved PARP Cell Signaling (#9541 HA Covance (MMS-101R) Histone H3 Cell Signaling (#9715) Integrin- α1 R&D (MAB5676) Integrin-α2 Santa Cruz (sc-74466) Integrin-α10 Millipore (AB6030) mTOR Cell Signaling (#2972) p-4EBP (T70) Cell Signaling (#9455) p-AKT (S473) Cell Signaling (#9271) p-AKT (T308) Cell Signaling (#4056) p-ERK Cell Signaling (#9106) p-FAK (Y397) Invitrogen (#44624G) p-PAK (T423) Cell Signaling (#2601) p-S6 (S240/244) Cell Signaling (#2215) p-SRC (Y416) Cell Signaling (#2101) PAK (total) Santa Cruz (sc-881) RAC BD Transduction Lab (#610650) RAPTOR Cell Signaling (#2280) RICTOR Cell Signaling (#2114) RICTOR Santa Cruz (sc50678) SIN1 Cell Signaling (#12860) TRIO Santa Cruz (sc-6060) Tubulin Sigma (T6074) Vinculin Sigma (V4505) p, phosphorylated Supplementary Table S7. Characteristics of the metastatic samples and matched primary samples analyzed for ITGA10 mRNA. # of Size of Time to Patient Sample Site of Primary Site of metastases metastasis metastasis no. description Lesion metastases * (cm) (months) Paired metastases 1 primary Thigh ------1 metastasis** Thigh Lung 1 3 10.1 1 metastasis** Thigh Lung 1 3.7 18.2 2 primary Thigh ------2 metastasis Thigh Pleura 1 2.8 93.1 3 primary Thigh ------3 metastasis Thigh Lung, Pleura 2 9.7 13.8 4 primary Thigh ------4 metastasis Thigh Lung 2 18.7 9.9 5 primary Thigh ------5 metastasis Thigh Lung 2 3.8 11.8 Unpaired metastases 6 metastasis Thigh Lung, Pleura 2 10.8 23.0 7 metastasis Leg Lung 2 8.5 128.8 8 metastasis Thigh Lung 2 6 18.5 9 metastasis Labia Lung 1 1.8 69.4 10 metastasis Arm Lung 9 *** 45.9 11 metastasis Thigh Lung 2 11 20.5

* at time of resected metastasis **in the matched pair analysis, only the first metastasis is shown; the ITGA10 mRNA level in the two metastases from this patient differed by less than 3% *** Multiple small lesions, unable to assess final size