Supplementary Tables Supplementary Table S1: Clinicopathologic characteristics of 64 patients with untreated primary myxofibrosarcoma Characteristic n (%) or median (range) Gender Male 23 (36%) Female 41 (64%) Age, years 63.5 (24-88) Location Extremity 55 (86%) Trunk/chest wall 8 (13%) Retroperitoneal 1 (1%) Size, cm ≤5 9 (14%) >5; ≤10 34 (53%) >10 21 (33%) Median 8.5 (3.1-25) Depth Superficial 12 (19%) Deep 52 (81%) Surgical margins R0 49 (77%) R1 15 (23%) Percent Myxoid 75% (10%-100%) Local Recurrence 14 (22%) Distant Recurrence 22 (34%) Died of Disease 17 (27%) Follow-up, years All patients 2.6 (0.1-9.2) Surviving patients 3.1 (0.4-9.2) Time to death, years 1.8 (0.7-3.3) 213338 at RIS1 3.00E-06 -2.45 219840 s at TCL6 1.30E-05 -0.25 201645 at TNC 2.00E-06 -2.15 208052 x at CEACAM3 1.40E-05 -0.25 205542 at STEAP1 1.70E-05 -1.74 210339 s at KLK2 1.40E-05 -0.25 212473 s at MICAL2 2.20E-05 -1.6 206612 at CACNG1 1.50E-05 -0.25 204337 at RGS4 <1.00E-06 -1.51 205531 s at GLS2 1.60E-05 -0.25 208025 s at HMGA2 4.50E-05 -1.51 215274 at SLC12A3 1.60E-05 -0.25 204464 s at EDNRA 6.00E-05 -1.48 216881 x at PRB4 1.60E-05 -0.25 208712 at CCND1 1.20E-05 -1.47 206869 at CHAD 1.80E-05 -0.25 201506 at TGFBI <1.00E-06 -1.32 207528 s at SLC7A11 1.80E-05 -0.25 203324 s at CAV2 <1.00E-06 -1.29 210577 at CASR 1.80E-05 -0.25 201617 x at CALD1 5.00E-06 -1.24 205815 at REG3A 1.90E-05 -0.25 206766 at ITGA10 2.60E-05 -1.23 208204 s at CAV3 1.90E-05 -0.25 209218 at SQLE <1.00E-06 -1.18 220581 at C6orf97 2.00E-05 -0.25 221773 at ELK3 <1.00E-06 -1.14 207007 at NR1I3 2.10E-05 -0.25 219926 at POPDC3 <1.00E-06 -1.14 208234 x at FGFR2 2.20E-05 -0.25 204017 at KDELR3 1.00E-05 -1.12 216600 x at ALDOB 2.50E-05 -0.25 209890 at TSPAN5 1.00E-05 -1.1 206812 at ADRB3 2.60E-05 -0.25 210845 s at PLAUR 9.00E-06 -1.07 207862 at UPK2 2.60E-05 -0.25 218424 s at STEAP3 9.00E-06 -1.07 204532 x at UGT1A10 2.70E-05 -0.25 212771 at C10orf38 6.00E-06 -1.05 211117 x at ESR2 2.70E-05 -0.25 221502 at KPNA3 <1.00E-06 -1.03 211689 s at TMPRSS2 2.70E-05 -0.25 207265 s at KDELR3 1.20E-05 -1.03 205840 x at GH1 2.90E-05 -0.25 212449 s at LYPLA1 <1.00E-06 -1 216128 at TBCD 2.90E-05 -0.25 218984 at FLJ20485 <1.00E-06 -0.99 220958 at ULK4 3.00E-05 -0.25 211924 s at PLAUR 2.30E-05 -0.99 221329 at OR52A1 3.00E-05 -0.25 202304 at FNDC3A <1.00E-06 -0.93 210641 at CAPN9 3.10E-05 -0.25 201300 s at PRNP 7.40E-05 -0.93 221456 at TAS2R3 3.20E-05 -0.25 221503 s at KPNA3 <1.00E-06 -0.9 31861 at IGHMBP2 3.20E-05 -0.25 208691 at TFRC 4.10E-05 -0.89 217017 at OSBPL10 3.50E-05 -0.25 201324 at EMP1 1.70E-05 -0.87 221184 at — 3.90E-05 -0.25 203323 at CAV2 9.70E-05 -0.87 204763 s at GNAO1 4.00E-05 -0.25 201063 at RCN1 4.00E-06 -0.86 216116 at — 4.30E-05 -0.25 220147 s at FAM60A 2.70E-05 -0.85 208139 s at — 4.90E-05 -0.25 214039 s at LAPTM4B 1.20E-05 -0.84 220902 at FLJ12616 4.90E-05 -0.25 204967 at APXL <1.00E-06 -0.83 215865 at SYT12 5.60E-05 -0.25 212887 at SEC23A 2.10E-05 -0.83 201974 s at C7orf28A 5.80E-05 -0.25 209286 at CDC42EP3 5.80E-05 -0.82 206630 at TYR 5.80E-05 -0.25 203999 at SYT1 3.90E-05 -0.81 218623 at HMP19 6.10E-05 -0.25 206805 at SEMA3A 8.00E-06 -0.8 220819 at FRMD1 6.10E-05 -0.25 204339 s at RGS4 <1.00E-06 -0.76 206679 at APBA1 6.20E-05 -0.25 202710 at BET1 1.10E-05 -0.76 207220 at DO 6.50E-05 -0.25 205453 at HOXB2 1.10E-05 -0.76 214088 s at FUT3 6.70E-05 -0.25 205199 at CA9 1.40E-05 -0.76 217134 at MTAP 7.30E-05 -0.25 212077 at CALD1 1.80E-05 -0.76 200724 at RPL10 7.50E-05 -0.25 204338 s at RGS4 8.30E-05 -0.76 207385 at TFDP3 7.60E-05 -0.25 204693 at CDC42EP1 <1.00E-06 -0.74 214956 at — 7.90E-05 -0.25 206713 at NTNG1 <1.00E-06 -0.73 216152 at PDZRN3 7.90E-05 -0.25 207431 s at DEGS1 <1.00E-06 -0.72 210744 s at IL5RA 8.70E-05 -0.25 219888 at SPAG4 2.00E-05 -0.72 217568 at FAM12A 8.70E-05 -0.25 205677 s at DLEU1 <1.00E-06 -0.71 206755 at CYP2B6 9.80E-05 -0.25 218796 at C20orf42 <1.00E-06 -0.7 217181 at — <1.00E-06 -0.24 216348 at RPS17* 2.00E-06 -0.7 220805 at HRH2 <1.00E-06 -0.24 212149 at KIAA0143 3.00E-06 -0.7 206930 at GLYAT <1.00E-06 -0.24 201921 at GNG10* 8.00E-06 -0.7 208311 at GPR50 <1.00E-06 -0.24 213102 at ACTR3 1.20E-05 -0.69 216085 at DKFZP434C153 <1.00E-06 -0.24 396 f at EPOR <1.00E-06 -0.68 201766 at ELAC2 2.00E-06 -0.24 200994 at IPO7 3.90E-05 -0.68 215829 at SHANK2 2.00E-06 -0.24 220603 s at MCTP2 3.00E-06 -0.67 217630 at ANGEL2 2.00E-06 -0.24 217975 at WBP5 1.40E-05 -0.67 220366 at ELSPBP1 2.00E-06 -0.24 221266 s at TM7SF4 <1.00E-06 -0.66 206290 s at RGS7 3.00E-06 -0.24 218516 s at IMPAD1 8.00E-06 -0.66 207368 at HTR1D 3.00E-06 -0.24 204575 s at MMP19 6.80E-05 -0.66 220732 at DEPDC2 3.00E-06 -0.24 218566 s at CHORDC1 <1.00E-06 -0.65 221459 at TAAR5 3.00E-06 -0.24 203438 at STC2 6.00E-06 -0.65 221644 s at SLC45A2 3.00E-06 -0.24 Myxofibrosarcoma 2 217266 at RPL15 1.80E-05 -0.65 208448 x at IFNA16 5.00E-06 -0.24 220167 s at TP53TG3 1.80E-05 -0.65 215003 at DGCR9 5.00E-06 -0.24 200639 s at YWHAZ <1.00E-06 -0.64 211786 at TNFRSF9 6.00E-06 -0.24 204729 s at STX1A <1.00E-06 -0.63 217619 x at — 7.00E-06 -0.24 214866 at PLAUR 3.00E-06 -0.63 220829 s at B3GALT1 9.00E-06 -0.24 205975 s at HOXD1 <1.00E-06 -0.62 206094 x at UGT1A6 1.10E-05 -0.24 216849 at FLJ16124 <1.00E-06 -0.62 91826 at EPS8L1 1.10E-05 -0.24 211936 at HSPA5 2.00E-06 -0.62 219943 s at FLJ11850 1.20E-05 -0.24 203119 at MGC2574 6.00E-06 -0.62 220930 s at MGC5590 1.20E-05 -0.24 218113 at TMEM2 1.20E-05 -0.62 216690 at OR7C1 1.30E-05 -0.24 221753 at SSH1 1.20E-05 -0.62 220886 at GABRQ 1.30E-05 -0.24 71933 at WNT6 <1.00E-06 -0.61 207214 at SPINK4 1.50E-05 -0.24 215479 at SEMA6A <1.00E-06 -0.61 208597 at CNTF 1.50E-05 -0.24 208161 s at ABCC3 6.00E-06 -0.61 215419 at KIAA1086 1.50E-05 -0.24 213100 at UNC5B 2.30E-05 -0.61 208507 at OR7C2 1.60E-05 -0.24 201358 s at COPB <1.00E-06 -0.6 216219 at AQP6 1.90E-05 -0.24 213577 at SQLE <1.00E-06 -0.6 219887 at FLJ10786 1.90E-05 -0.24 221347 at CHRM5 <1.00E-06 -0.6 220993 s at GPR63 1.90E-05 -0.24 206429 at F2RL1 3.90E-05 -0.6 220537 at MTMR8 2.10E-05 -0.24 219634 at CHST11 9.30E-05 -0.6 207951 at CSN2 2.30E-05 -0.24 209294 x at TNFRSF10B <1.00E-06 -0.59 216709 at — 2.30E-05 -0.24 220428 at CD207 <1.00E-06 -0.59 221429 x at TEX13A 2.30E-05 -0.24 209250 at DEGS1 2.00E-06 -0.59 215890 at GM2A 2.40E-05 -0.24 211452 x at LRRFIP1 1.40E-05 -0.59 216790 at — 2.70E-05 -0.24 217599 s at MDFIC 5.80E-05 -0.59 211384 s at CASR 2.80E-05 -0.24 221580 s at MGC5306 9.20E-05 -0.59 205845 at CACNA1H 3.10E-05 -0.24 200921 s at BTG1 9.90E-05 -0.59 216907 x at KIR3DL2 3.50E-05 -0.24 208203 x at KIR2DS5 <1.00E-06 -0.58 208062 s at NRG2 3.60E-05 -0.24 218644 at PLEK2 <1.00E-06 -0.58 216636 at — 3.80E-05 -0.24 219735 s at TFCP2L1 <1.00E-06 -0.58 205093 at PLEKHA6 4.00E-05 -0.24 211708 s at SCD 6.00E-06 -0.58 221285 at ST8SIA2 4.10E-05 -0.24 221330 at CHRM2 8.00E-06 -0.58 207421 at CA5A 4.20E-05 -0.24 214265 at ITGA8 1.60E-05 -0.58 211157 at — 4.30E-05 -0.24 201260 s at SYPL1 5.30E-05 -0.58 221035 s at TEX14 4.60E-05 -0.24 202488 s at FXYD3 <1.00E-06 -0.57 216986 s at IRF4 5.00E-05 -0.24 208520 at OR10H3 <1.00E-06 -0.57 208439 s at FCN2 5.10E-05 -0.24 210270 at RGS6 <1.00E-06 -0.57 214905 at LOC145899 5.10E-05 -0.24 219557 s at NRIP3 <1.00E-06 -0.57 208364 at INPP4A 5.20E-05 -0.24 205793 x at TNK1 <1.00E-06 -0.56 205772 s at AKAP7 5.50E-05 -0.24 216757 at GALNT7 <1.00E-06 -0.56 221422 s at C9orf45 5.70E-05 -0.24 217170 at — <1.00E-06 -0.56 206678 at GABRA1 6.10E-05 -0.24 206614 at GDF5 <1.00E-06 -0.56 91682 at EXOSC4 6.20E-05 -0.24 211945 s at ITGB1 5.00E-06 -0.56 211544 s at GHRHR 6.70E-05 -0.24 202211 at ARFGAP3 1.90E-05 -0.56 216079 at EPM2A 6.80E-05 -0.24 212245 at MCFD2 5.90E-05 -0.56 207874 s at CFHL4* 7.00E-05 -0.24 214805 at EIF4A1 6.00E-05 -0.56 216696 s at PRODH2 7.80E-05 -0.24 212364 at MYO1B 8.70E-05 -0.56 207698 at C6orf123 8.00E-05 -0.24 205832 at CPA4 <1.00E-06 -0.55 215824 at NUDT7 8.10E-05 -0.24 206186 at MPP3 <1.00E-06 -0.55 205064 at SPRR1B 8.30E-05 -0.24 211153 s at TNFSF11 <1.00E-06 -0.55 220282 at RIC3 8.40E-05 -0.24 215511 at TCF20 <1.00E-06 -0.55 220622 at LRRC31 8.80E-05 -0.24 211405 x at IFNA17 2.00E-06 -0.55 1494 f at CYP2A6 8.90E-05 -0.24 221112 at IL1RAPL2 2.00E-06 -0.55 207074 s at SLC18A1 8.90E-05 -0.24 219215 s at SLC39A4 1.90E-05 -0.55 204673 at MUC2 9.10E-05 -0.24 205031 at EFNB3 5.20E-05 -0.55 217008 s at GRM7 9.30E-05 -0.24 204411 at KIF21B <1.00E-06 -0.54 208593 x at CRHR1 9.50E-05 -0.24 217307 at — <1.00E-06 -0.54 220048 at EDAR 9.80E-05 -0.24 221114 at AMBN <1.00E-06 -0.54 216249 at PVT1 <1.00E-06 -0.23 202597 at IRF6 <1.00E-06 -0.54 207151 at ADCYAP1R1 <1.00E-06 -0.23 208378 x at FGF5 1.30E-05 -0.54 211214 s at DAPK1 <1.00E-06 -0.23 205137 x at USH1C <1.00E-06 -0.53 38707 r at E2F4 <1.00E-06 -0.23 211497 x at NKX3-1 <1.00E-06 -0.53 207770 x at CSH2 2.00E-06 -0.23 221313 at GPR52 <1.00E-06 -0.53 206199 at CEACAM7 4.00E-06 -0.23 205676 at CYP27B1 2.00E-06 -0.53 221395 at TAS2R13 6.00E-06 -0.23 214357 at C1orf105 2.00E-06 -0.53 211830 s at CACNA1I 7.00E-06 -0.23 211241 at ANXA2P3 1.60E-05 -0.53 211238 at ADAM7 9.00E-06 -0.23 200738 s at PGK1 1.70E-05 -0.53 216536 at OR7E19P 9.00E-06 -0.23 215823 x at PABPC3 2.20E-05 -0.53 206014 at ACTL6B 1.00E-05 -0.23 214053 at ERBB4 3.30E-05 -0.53 220192 x at SPDEF 1.00E-05 -0.23 209060 x at NCOA3 6.60E-05 -0.53 207751 at — 1.20E-05 -0.23 205402 x at PRSS2 <1.00E-06 -0.52 222373 at CIP29 1.30E-05 -0.23 207082 at CSF1 <1.00E-06 -0.52 216989 at SPAM1 1.50E-05 -0.23 208285 at OR7A5 <1.00E-06 -0.52 207227 x at RFPL2 1.60E-05 -0.23 210357 s at SMOX <1.00E-06 -0.52 220262 s at EGFL9 1.70E-05 -0.23 221090 s at FLJ10826 <1.00E-06 -0.52 220264