December 16, 2014 u vol. 111 u no. 50 u 17685–18090

Cover image: Pictured is an illustration of the crystal structure within a Frank–Kasper σ-phase formed by an asymmetric diblock copolymer. Competition between the tendency to form spherical core-shell micelles and the requirement to fill space without voids leads to five discrete polyhedral-shaped particles, depicted with different colors, which pack into a low-symmetry crystal structure. Sangwoo Lee et al. found that the breaking of higher sym- metry structure that leads to formation of a Frank–Kasper σ-phase occurs through a transfer of mass in this polymer system, suggesting that similar symmetry breaking in intermetallic alloys may occur through a transfer of charge. The results suggest analogies between phase transitions in disparate material classes and challenge the view that the formation of reduced symmetry structures requires particles with predetermined shapes or sizes. See the article by Lee et al. on pages 17723–17731. Image courtesy of Sangwoo Lee. From the Cover

17723 Breaking symmetry E5346 Recognizing African plants in the New World 17743 Archaeological wood conservation 17783 Identity fusion among revolutionaries 17977 Melanopsin and vascular photorelaxation

Contents SCIENCE AND CULTURE—How science intersects with culture 17687 Science and Culture: Capturing the world’s oldest living things Helen Fields THIS WEEK IN PNAS

17685 In This Issue INNER WORKINGS—An over-the-shoulder look at scientists at work

17688 Inner Workings: A soft robot that swims like a fish LETTERS (ONLINE ONLY) Stephen Ornes

E5331 Population matters when modeling hurricane fatalities Laura A. Bakkensen and William Larson RETROSPECTIVE E5333 Reply to Bakkensen and Larson: Population may matter but does not alter conclusions 17689 Robert Steinberg, 1922–2014 Kiju Jung, Sharon Shavitt, Madhu Viswanathan, V. S. Varadarajan and Joseph M. Hilbe E5334 Comment on the absence of ossified sternal elements in basal paravian dinosaurs Christian Foth PROFILES E5335 Reply to Foth: Preserved cartilage is rare but not absent: Troodontid sternal plates are absent, not rare 17690 Profile of Mary-Claire King, 2014 Lasker-Koshland Jingmai K. O’Connor, Min Wang, Xiaoting Zheng, Special Achievement in Medical Science Awardee and Zhonghe Zhou Aravinda Chakravarti 17693 Profile of Mahlon DeLong and Alim Benabid, 2014 Lasker-DeBakey Medical Research Awardees Free online through the PNAS open access option. C. Warren Olanow and Jose Obeso

PNAS u December 16, 2014 u vol. 111 u no. 50 u iii–viii Downloaded by guest on September 25, 2021 17696 Profile of Kazutoshi Mori and Peter Walter, 2014 Lasker 17923 Trophic coherence determines food-web stability Basic Medical Research Awardees: The unfolded Samuel Johnson, Virginia Domínguez-García, Luca protein response Donetti, and Miguel A. Muñoz Andrew Dillin

APPLIED PHYSICAL SCIENCES COMMENTARIES 17715 Microtubule nucleation remote from centrosomes may explain how asters span large cells Keisuke Ishihara, Phuong A. Nguyen, Aaron C. Groen, 17698 Explaining complex metals with polymers Christine M. Field, and Timothy J. Mitchison Ron Lifshitz See companion article on page 17723 17845 Power transduction of actin filaments ratcheting in vitro against a load 17700 Preserving ancient artifacts for the next millennia Damien Démoulin, Marie-France Carlier, Jérôme Bibette, Samuel L. Zelinka and Jean Baudry See companion article on page 17743

17702 Devoted actors sacrifice for close comrades and CHEMISTRY sacred cause Scott Atran, Hammad Sheikh, and Angel Gomez 17732 Observation of ice-like water layers at an aqueous See companion article on page 17783 protein surface Konrad Meister, Simona Strazdaite, Arthur L. DeVries, 17704 PDE and sGC hand in hand to see the light Stephan Lotze, Luuk L. C. Olijve, Ilja K. Voets, Paul M. Vanhoutte and Huib J. Bakker See companion article on page 17977 17737 Energetics of metastudtite and implications for nuclear waste alteration Xiaofeng Guo, Sergey V. Ushakov, Sabrina Labs, Hildegard PNAS PLUS Curtius, Dirk Bosbach, and Alexandra Navrotsky 17743 Multifunctional supramolecular polymer networks 17706 Significance Statements as next-generation consolidants for archaeological Brief statements written by the authors about the significance of wood conservation their papers. Zarah Walsh, Emma-Rose Janeˇcek, James T. Hodgkinson, Julia Sedlmair, Alexandros Koutsioubas, David R. Spring, Martin Welch, Carol J. Hirschmugl, PERSPECTIVE Chris Toprakcioglu, Jonathan R. Nitschke, Mark Jones, and Oren A. Scherman See Commentary on page 17700 17709 Reversals of national fortune, and social science methodologies 17851 Trapping the ATP binding state leads to a detailed Jared Diamond understanding of the F1-ATPase mechanism Kwangho Nam, Jingzhi Pu, and Martin Karplus 17857 Enzymatic turnover of macromolecules generates INAUGURAL ARTICLE long-lasting protein–water-coupled motions beyond reaction steady state Jessica Dielmann-Gessner, Moran Grossman, Valeria 17715 Microtubule nucleation remote from centrosomes may Conti Nibali, Benjamin Born, Inna Solomonov, explain how asters span large cells Gregg B. Fields, Martina Havenith, and Irit Sagi Keisuke Ishihara, Phuong A. Nguyen, Aaron C. Groen, Christine M. Field, and Timothy J. Mitchison EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 17749 Early inner solar system origin for anomalous sulfur FEATURE ARTICLE isotopes in differentiated protoplanets Michael A. Antonelli, Sang-Tae Kim, Marc Peters, 17723 Sphericity and symmetry breaking in the formation of Jabrane Labidi, Pierre Cartigny, Richard J. Walker, Frank–Kasper phases from one component materials James R. Lyons, Joost Hoek, and James Farquhar Sangwoo Lee, Chris Leighton, and Frank S. Bates 17755 Hidden carbon in Earth’s inner core revealed by shear See Commentary on page 17698 softening in dense Fe7C3 Bin Chen, Zeyu Li, Dongzhou Zhang, Jiachao Liu, Michael Y. Hu, Jiyong Zhao, Wenli Bi, E. Ercan Alp, PHYSICAL SCIENCES Yuming Xiao, Paul Chow, and Jie Li

APPLIED MATHEMATICS ENGINEERING E5336 Robust spectrotemporal decomposition by iteratively 18025 Label-free imaging of Schwann cell myelination by reweighted least squares third harmonic generation microscopy Demba Ba, Behtash Babadi, Patrick L. Purdon, Hyungsik Lim, Denis Sharoukhov, Imran Kassim, Yanqing and Emery N. Brown Zhang, James L. Salzer, and Carmen V. Melendez-Vasquez

iv u www.pnas.org Downloaded by guest on September 25, 2021 MATHEMATICS APPLIED BIOLOGICAL SCIENCES 17759 Groups graded by root systems and property (T) 17803 Evolution-guided optimization of Mikhail Ershov, Andrei Jaikin-Zapirain, Martin Kassabov, biosynthetic pathways and Zezhou Zhang Srivatsan Raman, Jameson K. Rogers, Noah D. Taylor, and George M. Church PHYSICS 17723 Sphericity and symmetry breaking in the formation of BIOCHEMISTRY – Frank Kasper phases from one component materials 17809 Self-assembled FUS binds active chromatin and Sangwoo Lee, Chris Leighton, and Frank S. Bates regulates gene transcription See Commentary on page 17698 Liuqing Yang, Jozsef Gal, Jing Chen, and Haining Zhu 17765 Invariance property of wave scattering through 17815 Erythritol feeds the pentose phosphate disordered media pathway via three new isomerases leading to Romain Pierrat, Philipp Ambichl, Sylvain Gigan, Alexander D-erythrose-4-phosphate in Brucella Haber, Rémi Carminati, and Stefan Rotter Thibault Barbier, François Collard, Amaia Zúñiga-Ripa, 17771 Flagellated bacterial motility in polymer solutions Ignacio Moriyón, Thibault Godard, Judith Becker, Vincent A. Martinez, Jana Schwarz-Linek, Mathias Christoph Wittmann, Emile Van Schaftingen, Reufer, Laurence G. Wilson, Alexander N. Morozov, and Jean-Jacques Letesson and Wilson C. K. Poon 17821 Site-specific cation release drives actin filament severing by vertebrate cofilin Hyeran Kang, Michael J. Bradley, Wenxiang Cao, Kaifeng Zhou, Elena E. Grintsevich, Alphée Michelot, SOCIAL SCIENCES Charles V. Sindelar, Mark Hochstrasser, and Enrique M. De La Cruz ANTHROPOLOGY 17827 Direct interactions promote eviction of the Sir3 E5346 Local plant names reveal that enslaved Africans heterochromatin protein by the SWI/SNF chromatin recognized substantial parts of the New World flora remodeling enzyme Tinde R. van Andel, Charlotte I. E. A. van ‘t Klooster, Benjamin J. Manning and Craig L. Peterson Diana Quiroz, Alexandra M. Towns, Sofie Ruysschaert, 17833 Stoichiometry and assembly of mTOR complexes and Margot van den Berg revealed by single-molecule pulldown Ankur Jain, Edwin Arauz, Vasudha Aggarwal, Nikita ECONOMIC SCIENCES Ikon, Jie Chen, and Taekjip Ha 17777 The origin of risk aversion 17839 Full-length structure of a monomeric histidine kinase Ruixun Zhang, Thomas J. Brennan, and Andrew W. Lo reveals basis for sensory regulation Giomar Rivera-Cancel, Wen-huang Ko, Diana R. Tomchick, Fernando Correa, and Kevin H. Gardner PSYCHOLOGICAL AND COGNITIVE SCIENCES 17783 Brothers in arms: Libyan revolutionaries bond like family Harvey Whitehouse, Brian McQuinn, Michael Buhrmester, BIOPHYSICS AND COMPUTATIONAL BIOLOGY and William B. Swann Jr. E5354 Sodium recognition by the Na+/Ca2+ exchanger in the See Commentary on page 17702 outward-facing conformation Fabrizio Marinelli, Lior Almagor, Reuben Hiller, Moshe 17786 Effects of biological explanations for mental disorders Giladi, Daniel Khananshvili, and José D. Faraldo-Gómez on clinicians’ empathy Matthew S. Lebowitz and Woo-kyoung Ahn E5363 Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation SUSTAINABILITY SCIENCE Irina Kufareva, Bryan S. Stephens, Lauren G. Holden, 17791 Social, institutional, and knowledge mechanisms Ling Qin, Chunxia Zhao, Tetsuya Kawamura, Ruben mediate diverse ecosystem service benefits from Abagyan, and Tracy M. Handel coral reefs Christina C. Hicks and Joshua E. Cinner 17732 Observation of ice-like water layers at an aqueous protein surface Konrad Meister, Simona Strazdaite, Arthur L. DeVries, Stephan Lotze, Luuk L. C. Olijve, Ilja K. Voets, BIOLOGICAL SCIENCES and Huib J. Bakker 17765 Invariance property of wave scattering through AGRICULTURAL SCIENCES disordered media Romain Pierrat, Philipp Ambichl, Sylvain Gigan, Alexander 17797 Molecular basis of a shattering resistance boosting Haber, Rémi Carminati, and Stefan Rotter global dissemination of soybean Hideyuki Funatsuki, Masaya Suzuki, Aya Hirose, Hiroki 17845 Power transduction of actin filaments ratcheting in vitro Inaba, Tetsuya Yamada, Makita Hajika, Kunihiko Komatsu, against a load Takeshi Katayama, Takashi Sayama, Masao Ishimoto, Damien Démoulin, Marie-France Carlier, Jérôme Bibette, and Kaien Fujino and Jean Baudry

PNAS u December 16, 2014 u vol. 111 u no. 50 u v Downloaded by guest on September 25, 2021 17851 Trapping the ATP binding state leads to a detailed 17911 DNA methyltransferase 3B regulates duration of

understanding of the F1-ATPase mechanism neural crest production via repression of Sox10 Kwangho Nam, Jingzhi Pu, and Martin Karplus Na Hu, Pablo H. Strobl-Mazzulla, Marcos Simoes-Costa, Estefania Sánchez-Vásquez, and Marianne E. Bronner 17857 Enzymatic turnover of macromolecules generates long-lasting protein–water-coupled motions 17917 Regulatory modulation of the T-box gene Tbx5 links beyond reaction steady state development, evolution, and adaptation of the sternum Jessica Dielmann-Gessner, Moran Grossman, Valeria Sorrel R. B. Bickley and Malcolm P. O. Logan Conti Nibali, Benjamin Born, Inna Solomonov, Gregg B. Fields, Martina Havenith, and Irit Sagi ECOLOGY 17863 Metal ion and ligand binding of integrin α β 5 1 17923 Trophic coherence determines food-web stability Wei Xia and Timothy A. Springer Samuel Johnson, Virginia Domínguez-García, Luca 17869 Crucial role of nonspecific interactions in Donetti, and Miguel A. Muñoz amyloid nucleation Andela Saric, Yassmine C. Chebaro, Tuomas P. J. Knowles, and Daan Frenkel EVOLUTION 17875 Computational design of a leucine-rich repeat protein E5393 Impact of HLA-driven HIV adaptation on virulence with a predefined geometry in populations of high HIV seroprevalence Sebastian Rämisch, Ulrich Weininger, Jonas Martinsson, Rebecca Payne, Maximilian Muenchhoff, Jaclyn Mann, Hannah E. Roberts, Philippa Matthews, Emily Adland, Mikael Akke, and Ingemar André Allison Hempenstall, Kuan-Hsiang Huang, Mark Brockman, 17881 The charged linker of the molecular chaperone Hsp90 Zabrina Brumme, Marc Sinclair, Toshiyuki Miura, John modulates domain contacts and biological function Frater, Myron Essex, Roger Shapiro, Bruce D. Walker, Markus Jahn, Alexandra Rehn, Benjamin Pelz, Björn Thumbi Ndung’u, Angela R. McLean, Jonathan M. Hellenkamp, Klaus Richter, Matthias Rief, Johannes Carlson, and Philip J. R. Goulder Buchner, and Thorsten Hugel 17929 Neuromolecular responses to social challenge: 17887 Conformational dynamics of a crystalline protein Common mechanisms across mouse, stickleback fish, from microsecond-scale molecular dynamics and honey bee simulations and diffuse X-ray scattering Clare C. Rittschof, Syed Abbas Bukhari, Laura G. Sloofman, Michael E. Wall, Andrew H. Van Benschoten, Nicholas K. Joseph M. Troy, Derek Caetano-Anollés, Amy Cash-Ahmed, Sauter, Paul D. Adams, James S. Fraser, Molly Kent, Xiaochen Lu, Yibayiri O. Sanogo, Patricia A. and Thomas C. Terwilliger Weisner, Huimin Zhang, Alison M. Bell, Jian Ma, Saurabh Sinha, Gene E. Robinson, and Lisa Stubbs 17893 Nucleosomal promoter variation generates gene expression noise 17935 Evolution in changing environments: Modifiers of Christopher R. Brown and Hinrich Boeger mutation, recombination, and migration Oana Carja, Uri Liberman, and Marcus W. Feldman CELL BIOLOGY 17941 Evolutionary limits to cooperation in E5373 The Toll/NF-κB signaling pathway is required for microbial communities epidermal wound repair in Drosophila Nuno M. Oliveira, Rene Niehus, and Kevin R. Foster Lara Carvalho, António Jacinto, and Nina Matova

E5383 Recessive cardiac phenotypes in induced pluripotent GENETICS stem cell models of Jervell and Lange-Nielsen syndrome: E5401 Genomic and functional analysis of leukemic Disease mechanisms and pharmacological rescue transformation of myeloproliferative neoplasms Miao Zhang, Cristina D’Aniello, Arie O. Verkerk, Eva Raajit Rampal, Jihae Ahn, Omar Abdel-Wahab, Michelle Wrobel, Stefan Frank, Dorien Ward-van Oostwaard, Ilaria Nahas, Kai Wang, Doron Lipson, Geoff A. Otto, Roman Piccini, Christian Freund, Jyoti Rao, Guiscard Seebohm, Yelensky, Todd Hricik, Anna Sophia McKenney, Gabriela Douwe E. Atsma, Eric Schulze-Bahr, Christine L. Chiosis, Young Rock Chung, Suveg Pandey, Marcel R. M. Mummery, Boris Greber, and Milena Bellin van den Brink, Scott A. Armstrong, Ahmet Dogan, 17715 Microtubule nucleation remote from centrosomes may Andrew Intlekofer, Taghi Manshouri, Christopher Y. explain how asters span large cells Park, Srdan Verstovsek, Franck Rapaport, Philip J. Keisuke Ishihara, Phuong A. Nguyen, Aaron C. Groen, Stephens, Vincent A. Miller, and Ross L. Levine Christine M. Field, and Timothy J. Mitchison 17947 Dissecting the clonal origins of childhood acute + 17899 Oscillatory AAA ATPase Knk1 constitutes a novel lymphoblastic leukemia by single-cell genomics morphogenetic pathway in fission yeast Charles Gawad, Winston Koh, and Stephen R. Quake Kathleen Scheffler, Pierre Recouvreux, Anne Paoletti, and Phong T. Tran 17953 Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency Ravikumar Balasubramanian, Jin-Ho Choi, Ludmila DEVELOPMENTAL BIOLOGY Francescatto, Jason Willer, Edward R. Horton, Eleni P. 17905 Communication between oocytes and somatic cells Asimacopoulos, Konstantina M. Stankovic, Lacey Plummer, regulates volatile pheromone production in Cassandra L. Buck, Richard Quinton, Todd D. Nebesio, Caenorhabditis elegans Veronica Mericq, Paulina M. Merino, Brian F. Meyer, Daniel H. W. Leighton, Andrea Choe, Shannon Y Wu, Dorota Monies, James F. Gusella, Nada Al Tassan, and Paul W. Sternberg Nicholas Katsanis, and William F. Crowley Jr.

vi u www.pnas.org Downloaded by guest on September 25, 2021 17959 Control of metabolic adaptation to fasting by 17995 Repurposing of bisphosphonates for the prevention and dILP6-induced insulin signaling in Drosophila oenocytes therapy of nonsmall cell lung and breast cancer Debamita Chatterjee, Subhash D. Katewa, Agnes Stachnik, Tony Yuen, Jameel Iqbal, Miriam Sgobba, Yanyan Qi, Susan A. Jackson, Pankaj Kapahi, Yogesh Gupta, Ping Lu, Graziana Colaianni, Yaoting Ji, and Heinrich Jasper Ling-Ling Zhu, Se-Min Kim, Jianhua Li, Peng Liu, Sudeh Izadmehr, Jaya Sangodkar, Thomas Scherer, Shiraz Mujtaba, Matthew Galsky, Jorge Gomez, Solomon IMMUNOLOGY AND INFLAMMATION Epstein, Christoph Buettner, Zhuan Bian, Alberta E5411 Miz-1 regulates translation of Trp53 via ribosomal Zallone, Aneel K. Aggarwal, Shozeb Haider, Maria I. protein L22 in cells undergoing V(D)J recombination New, Li Sun, Goutham Narla, and Mone Zaidi Marissa Rashkovan, Charles Vadnais, Julie Ross, 18001 Detection of brown adipose tissue and thermogenic Mathieu Gigoux, Woong-Kyung Suh, Wei Gu, activity in mice by hyperpolarized xenon MRI Christian Kosan, and Tarik Möröy Rosa Tamara Branca, Ting He, Le Zhang, Carlos S. Floyd, 17965 Antibody-driven design of a human cytomegalovirus Matthew Freeman, Christian White, and Alex Burant gHgLpUL128L subunit vaccine that selectively elicits 18007 Constitutively active Notch4 receptor elicits brain potent neutralizing antibodies arteriovenous malformations through enlargement Anna Kabanova, Laurent Perez, Daniele Lilleri, Jessica of capillary-like vessels Marcandalli, Gloria Agatic, Simone Becattini, Silvia Patrick A. Murphy, Tyson N. Kim, Lawrence Huang, Preite, Dario Fuschillo, Elena Percivalle, Federica Corinne M. Nielsen, Michael T. Lawton, Ralf H. Adams, Sallusto, Giuseppe Gerna, Davide Corti, Chris B. Schaffer, and Rong A. Wang and Antonio Lanzavecchia

17971 FcγRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis MICROBIOLOGY Menna R. Clatworthy, Sarah K. Harford, Rebeccah J. E5439 Structure of the nonameric bacterial amyloid Mathews, and Kenneth G. C. Smith secretion channel Baohua Cao, Yan Zhao, Yongjun Kou, Dongchun Ni, Xuejun Cai Zhang, and Yihua Huang MEDICAL SCIENCES 18013 Type IV pili interactions promote intercellular association E5420 Overactive cannabinoid 1 receptor in podocytes and moderate swarming of Pseudomonas aeruginosa drives type 2 diabetic nephropathy Morgen E. Anyan, Aboutaleb Amiri, Cameron W. Harvey, Tony Jourdan, Gergo} Szanda, Avi Z. Rosenberg, Giordano Tierra, Nydia Morales-Soto, Callan M. Driscoll, Joseph Tam, Brian James Earley, Grzegorz Godlewski, Mark S. Alber, and Joshua D. Shrout Resat Cinar, Ziyi Liu, Jie Liu, Cynthia Ju, Pál Pacher, and George Kunos 18019 Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP–sugar synthesis to support E5429 Hypoxia-inducible factors are required for viral protein glycosylation chemotherapy resistance of breast cancer Stefanie Renee DeVito, Emilio Ortiz-Riaño, Luis stem cells Martínez-Sobrido, and Joshua Munger Debangshu Samanta, Daniele M. Gilkes, Pallavi Chaturvedi, Lisha Xiang, and Gregg L. Semenza NEUROSCIENCE 17977 Melanopsin mediates light-dependent relaxation in blood vessels E5445 Human infrared vision is triggered by two-photon Gautam Sikka, G. Patrick Hussmann, Deepesh Pandey, chromophore isomerization Suyi Cao, Daijiro Hori, Jong Taek Park, Jochen Steppan, Grazyna Palczewska, Frans Vinberg, Patrycjusz Stremplewski, Jae Hyung Kim, Viachaslau Barodka, Allen C. Myers, Martin P. Bircher, David Salom, Katarzyna Komar, Jianye Lakshmi Santhanam, Daniel Nyhan, Marc K. Halushka, Zhang, Michele Cascella, Maciej Wojtkowski, Vladimir J. Raymond C. Koehler, Solomon H. Snyder, Larissa A. Kefalov, and Krzysztof Palczewski Shimoda, and Dan E. Berkowitz 18025 Label-free imaging of Schwann cell myelination by See Commentary on page 17704 third harmonic generation microscopy 17983 Life-long in vivo cell-lineage tracing shows that no Hyungsik Lim, Denis Sharoukhov, Imran Kassim, Yanqing oogenesis originates from putative germline Zhang, James L. Salzer, and Carmen V. Melendez-Vasquez stem cells in adult mice 18031 Tobacco smoking interferes with GABA receptor Hua Zhang, Lian Liu, Xin Li, Kiran Busayavalasa, A neuroadaptations during prolonged alcohol withdrawal Yan Shen, Outi Hovatta, Jan-Åke Gustafsson, Kelly P. Cosgrove, Reese McKay, Irina Esterlis, Tracy and Kui Liu Kloczynski, Evgenia Perkins, Frederic Bois, Brian Pittman, 17989 Bisphosphonates inactivate human EGFRs to exert Jack Lancaster, David C. Glahn, Stephanie O’Malley, antitumor actions Richard E. Carson, and John H. Krystal Tony Yuen, Agnes Stachnik, Jameel Iqbal, Miriam 18037 Effect of distracting faces on visual selective attention Sgobba, Yogesh Gupta, Ping Lu, Graziana Colaianni, in the monkey Yaoting Ji, Ling-Ling Zhu, Se-Min Kim, Jianhua Li, Rogier Landman, Jitendra Sharma, Mriganka Sur, Peng Liu, Sudeh Izadmehr, Jaya Sangodkar, Jack Bailey, and Robert Desimone Yathin Latif, Shiraz Mujtaba, Solomon Epstein, Terry F. Davies, Zhuan Bian, Alberta Zallone, Aneel K. Aggarwal, 18043 Reliability-dependent contributions of visual Shozeb Haider, Maria I. New, Li Sun, Goutham Narla, orientation cues in parietal cortex and Mone Zaidi Ari Rosenberg and Dora E. Angelaki

PNAS u December 16, 2014 u vol. 111 u no. 50 u vii Downloaded by guest on September 25, 2021 18049 Dendrites are dispensable for basic motoneuron 18078 Enhanced activation of an amino-terminally truncated function but essential for fine tuning of behavior isoform of the voltage-gated proton channel HVCN1 Stefanie Ryglewski, Dimitrios Kadas, Katie Hutchinson, enriched in malignant B cells Natalie Schuetzler, Fernando Vonhoff, and Carsten Duch Elayne Hondares, Mark Adrian Brown, Boris Musset, Deri Morgan, Vladimir V. Cherny, Christina Taubert, 18055 p53 prevents neurodegeneration by regulating Mandeep K. Bhamrah, David Coe, Federica Marelli-Berg, synaptic genes John G. Gribben, Martin J. S. Dyer, Thomas E. Paola Merlo, Bess Frost, Shouyong Peng, Yawei J. Yang, DeCoursey, and Melania Capasso Peter J. Park, and Mel Feany

18061 Multiple functional therapeutic effects of the estrogen PLANT BIOLOGY receptor β agonist indazole-Cl in a mouse model of multiple sclerosis E5346 Local plant names reveal that enslaved Africans Spencer M. Moore, Anna J. Khalaj, Shalini Kumar, Zachary recognized substantial parts of the New World flora ‘ Winchester, JaeHee Yoon, Timothy Yoo, Leonardo Tinde R. van Andel, Charlotte I. E. A. van t Klooster, Martinez-Torres, Norio Yasui, John A. Katzenellenbogen, Diana Quiroz, Alexandra M. Towns, Sofie Ruysschaert, and Seema Kaushalya Tiwari-Woodruff and Margot van den Berg 18067 Intrinsically organized resting state networks in the E5471 Bimodal regulation of ICR1 levels generates human spinal cord self-organizing auxin distribution Yazhuo Kong, Falk Eippert, Christian F. Beckmann, Ora Hazak, Uri Obolski, Tomás Prat, Jirí Friml, Jesper Andersson, Jürgen Finsterbusch, Christian Büchel, Lilach Hadany, and Shaul Yalovsky Irene Tracey, and Jonathan C. W. Brooks E5480 Evolution of a plant-specific copper chaperone family for chloroplast copper homeostasis Crysten E. Blaby-Haas, Teresita Padilla-Benavides, PHARMACOLOGY Roland Stübe, José M. Argüello, and Sabeeha S. Merchant E5455 (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance 18084 Carlactone is converted to carlactonoic acid by MAX1 of Plasmodium in Arabidopsis and its methyl ester can directly María Belén Jiménez-Díaz, Daniel Ebert, Yandira interact with AtD14 in vitro Salinas, Anupam Pradhan, Adele M. Lehane, Marie-Eve Satoko Abe, Aika Sado, Kai Tanaka, Takaya Kisugi, Myrand-Lapierre, Kathleen G. O’Loughlin, David M. Kei Asami, Saeko Ota, Hyun Il Kim, Kaori Yoneyama, Shackleford, Mariana Justino de Almeida, Angela K. Xiaonan Xie, Toshiyuki Ohnishi, Yoshiya Seto, Shinjiro Carrillo, Julie A. Clark, Adelaide S. M. Dennis, Yamaguchi, Kohki Akiyama, Koichi Yoneyama, Jonathon Diep, Xiaoyan Deng, Sandra Duffy, Aaron N. and Takahito Nomura Endsley, Greg Fedewa, W. Armand Guiguemde, María G. Gómez, Gloria Holbrook, Jeremy Horst, Charles C. Kim, Jian Liu, Marcus C. S. Lee, Amy Matheny, María Santos Martínez, Gregory Miller, Ane Rodríguez-Alejandre, Laura CORRECTIONS Sanz, Martina Sigal, Natalie J. Spillman, Philip D. Stein, Zheng Wang, Fangyi Zhu, David Waterson, Spencer EVOLUTION Knapp, Anang Shelat, Vicky M. Avery, David A. Fidock, Francisco-Javier Gamo, Susan A. Charman, Jon C. 18090 Evolved tooth gain in sticklebacks is associated with Mirsalis, Hongshen Ma, Santiago Ferrer, Kiaran Kirk, a cis-regulatory allele of Bmp6 Iñigo Angulo-Barturen, Dennis E. Kyle, Joseph L. Phillip A. Cleves, Nicholas A. Ellis, Monica T. Jimenez, DeRisi, David M. Floyd, and R. Kiplin Guy Stephanie M. Nunez, Dolph Schluter, David M. Kingsley, and Craig T. Miller

PHYSIOLOGY NEUROSCIENCE E5463 Structural interactions of a voltage sensor toxin with 18090 Brain sensitivity to print emerges when children learn lipid membranes letter–speech sound correspondences Mihaela Mihailescu, Dmitriy Krepkiy, Mirela Milescu, Silvia Brem, Silvia Bach, Karin Kucian, Tomi K. Guttorm, Klaus Gawrisch, Kenton J. Swartz, and Stephen White Ernst Martin, Heikki Lyytinen, Daniel Brandeis, and Ulla Richardson 18073 hERG 1b is critical for human cardiac repolarization David K. Jones, Fang Liu, Ravi Vaidyanathan, L. Lee Eckhardt, Matthew C. Trudeau, and Gail A. Robertson ix Subscription Form

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