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Pterossauros Nasciam Sem a Capacidade De Voar
NOTAS 1 Pterossauros nasciam sem a capacidade de voar Os filhotes de pterossauros, répteis ala- dos já extintos, contemporâneos dos dinossauros, rompiam seus ovos prontos para andar, mas não para bater asas e ga- nhar os ares. Assim que nasciam, os ossos Ovos fossilizados da cintura estavam formados. Isso permi- do pterossauro Hamipterus tia que eles se apoiassem sobre as patas tianshanensis e traseiras e dessem os primeiros passos. reconstituição Porém, a estrutura óssea que dá suporte artística da espécie aos movimentos do músculo peitoral, essencial para sustentar o voo, ainda não estava totalmente constituída. Os recém- -nascidos também não tinham todos os dentes, limitação que provavelmente os impedia de se alimentar sozinhos. Para sobreviver até que os ossos de apoio das asas e os dentes estivessem completos, os filhotes tinham de permanecer um bom tempo sob o cuidado dos pais. Esse cenário, sobre o desenvolvimento embrio- nário e os primeiros movimentos, ainda tímidos, dos filhotes de pterossauros, é sugerido em um estudo feito por paleon- tólogos brasileiros e chineses (Science, 1º de dezembro). “O descompasso entre o desenvolvimento dos ossos da cintura e os da musculatura peitoral indica que os pterossauros não conseguiam voar ao nascer”, comenta o paleontólogo Ale- xander Kellner, do Museu Nacional da Universidade Federal do Rio de Janeiro (UFRJ), um dos autores do trabalho. Com o auxílio de imagens de tomografia com- putadorizada, o grupo analisou o interior de 16 ovos de pterossauros da espécie Hamipterus tianshanensis, que viveu há cerca de 120 milhões de anos na bacia de Turpan-Hami, no noroeste da China. -
Professor Peter Goldreich Member of the Board of Adjudicators Chairman of the Selection Committee for the Prize in Astronomy
The Shaw Prize The Shaw Prize is an international award to honour individuals who are currently active in their respective fields and who have recently achieved distinguished and significant advances, who have made outstanding contributions in academic and scientific research or applications, or who in other domains have achieved excellence. The award is dedicated to furthering societal progress, enhancing quality of life, and enriching humanity’s spiritual civilization. Preference is to be given to individuals whose significant work was recently achieved and who are currently active in their respective fields. Founder's Biographical Note The Shaw Prize was established under the auspices of Mr Run Run Shaw. Mr Shaw, born in China in 1907, was a native of Ningbo County, Zhejiang Province. He joined his brother’s film company in China in the 1920s. During the 1950s he founded the film company Shaw Brothers (HK) Limited in Hong Kong. He was one of the founding members of Television Broadcasts Limited launched in Hong Kong in 1967. Mr Shaw also founded two charities, The Shaw Foundation Hong Kong and The Sir Run Run Shaw Charitable Trust, both dedicated to the promotion of education, scientific and technological research, medical and welfare services, and culture and the arts. ~ 1 ~ Message from the Chief Executive I warmly congratulate the six Shaw Laureates of 2014. Established in 2002 under the auspices of Mr Run Run Shaw, the Shaw Prize is a highly prestigious recognition of the role that scientists play in shaping the development of a modern world. Since the first award in 2004, 54 leading international scientists have been honoured for their ground-breaking discoveries which have expanded the frontiers of human knowledge and made significant contributions to humankind. -
Kazutoshi Mori and Peter Walter Receive the 2014 Albert Lasker Basic Medical Research Award
Kazutoshi Mori and Peter Walter receive the 2014 Albert Lasker Basic Medical Research Award Corinne L. Williams J Clin Invest. 2014;124(10):4138-4142. https://doi.org/10.1172/JCI78419. News Cells are continuously faced with life-and-death decisions based on their ability to handle stressful situations. One indicator of stress is the accumulation of unfolded proteins within the ER, which induces a transcriptional cascade aimed at increasing the folding capacity of the ER. If the burden is too great and homeostasis cannot be restored, the response shifts from damage control to the induction of apoptotic pathways. This unfolded protein response (UPR) is conserved among all eukaryotes, and dysfunction in this pathway underlies many human diseases, including diabetes and cancer. The 2014 Albert Lasker Basic Medical Research award honors Kazutoshi Mori of Kyoto University and Peter Walter of the UCSF (Figure 1) for their contributions toward unraveling the pathways involved in mediating the complex cellular response to ER stress. A simple question In the 1970s, the identification of a set of proteins that were induced in response to viral transformation set the stage for understanding heat shock-independent cellular stress responses. These particular proteins were constitutively present in cells and notably increased in response to glucose deprivation (1) or agents that block post-translational glycosylation, such as tunicamycin. Based on this apparent glucose-dependent regulation, they became known as glucose-regulated proteins (GRPs). One -
Special Edition: Woman Researchers in Kyoto University Vol
Kyoto University Kyoto UniversityKyoto Research Activities Vol.4 No.1 June 2014 Special Edition: Woman Researchers in Kyoto University Vol . 4 No.1 June 2014 Vol.4 No.1 June 2014 Contents Message from the President 1 Promoting a Gender-Equal Research Environment About the Special Issue 2 Message to Our Readers Awards & Honors 4 International Recognition of Kyoto University’s Research Introduction 6 Women in University Research Research Frontiers 10 Cutting-Edge Research in Kyoto University Looking Back 18 A Female Student in the Pioneer Days Encourage Women to Research 20 The Tachibana Award Brief History 26 Ten Years of Gender Equality at KU Programs and Services 28 Gender Equality Promotion Center 31 Summary of Kyoto University 32 Author Index Cover: Clock Tower 33 Map and Access ■▶ p.14 Message from the President Message from the President Promoting a Gender-Equal Research Environment HE NUMBER and ratio of female scholars engaged in research at universities in Japan still remains remarkably T low compared to many other countries. This highlights an area of Japan’s academic environment and system in which there is still plenty of room for improvement. Despite this, however, it is also true that there are many female Japanese scientists who are internationally recognized as outstanding in their fields. It is all the more vital, therefore, to create an environment in which they can fully exercise their capabilities and flourish. To this end, Kyoto University is focusing its efforts on developing a research environment in which all scholars can fully and freely pursue their research regardless of gender. -
Table of Contents (PDF)
April 21, 2015 u vol. 112 u no. 16 u 4833–5254 Cover image: Pictured are marine fossils from a Late Ordovician seafloor uncovered in southwestern Ohio, including a dozen species of brachiopods (large shell in lower right, 1 cm wide), crinoids, and trilobites—three groups that were mainstays of Paleozoic biota but are obscure or absent in modern seas—as well as bryozoans and ostracods. These invertebrates were likely buried during a hurricane, which struck a shallow trop- ical sea that covered most of North America nearly 450 million years ago, leaving behind a rich fossil record that has supported a wide range of evolutionary and ecolog- ical analyses. David Jablonski and Neil H. Shubin introduce the Future of the Fossil Record Special Feature, which describes advances in understanding the origin and evolution of life that emerge from the intersection of paleontology with diverse natural sciences disciplines. See the Introduction to the Special Feature by Jablonski and Shubin on pages 4852–4858. Image courtesy of Steven M. Holland (University of Georgia, Athens, GA). From the Cover 4852 Paleontology, origins, and evolution E2004 Contact between intracellular membranes E2102 Human sex ratio from conception to birth 4952 Probing supercooled liquids Contents CORE CONCEPTS—A brief introduction to emerging topics in science 4835 Core Concept: Capturing atoms in motion Danielle Venton THIS WEEK IN PNAS 4833 In This Issue COMMENTARIES LETTERS (ONLINE ONLY) 4837 Extended synaptotagmins (E-Syts): Architecture and dynamics of membrane contact sites revealed E1968 LQT1-phenotypes in hiPSC: Are we measuring the Ángel Pérez-Lara and Reinhard Jahn right thing? See companion article on page E2004 Torsten Christ, András Horvath, and Thomas Eschenhagen 4839 The human prenatal sex ratio: A major surprise E1969 Reply to Christ et al.: LQT1 and JLNS phenotypes in Steven N. -
Lasker Interactive Research Nom'18.Indd
THE 2018 LASKER MEDICAL RESEARCH AWARDS Nomination Packet albert and mary lasker foundation November 1, 2017 Greetings: On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination for the 2018 Lasker Medical Research Awards. Since 1945, the Lasker Awards have recognized the contributions of scientists, physicians, and public citizens who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of disease. The Medical Research Awards will be offered in three categories in 2018: Basic Research, Clinical Research, and Special Achievement. The Lasker Foundation seeks nominations of outstanding scientists; nominations of women and minorities are encouraged. Nominations that have been made in previous years are not automatically reconsidered. Please see the Nomination Requirements section of this booklet for instructions on updating and resubmitting a nomination. The Foundation accepts electronic submissions. For information on submitting an electronic nomination, please visit www.laskerfoundation.org. Lasker Awards often presage future recognition of the Nobel committee, and they have become known popularly as “America’s Nobels.” Eighty-seven Lasker laureates have received the Nobel Prize, including 40 in the last three decades. Additional information on the Awards Program and on Lasker laureates can be found on our website, www.laskerfoundation.org. A distinguished panel of jurors will select the scientists to be honored with Lasker Medical Research Awards. The 2018 Awards will -
SCHEDULE of EVENTS Saturday, April 5 ALL SESSIONS ELIGIBLE for CME CREDIT UNLESS OTHERWISE NOTED.*
09_14AM_SchedEvents_Layout 1 3/11/14 12:29 PM Page 101 SCHEDULE OF EVENTS Saturday, April 5 ALL SESSIONS ELIGIBLE FOR CME CREDIT UNLESS OTHERWISE NOTED.* Saturday, April 5, 2014 Integrative Molecular Epidemiology , Thomas A. Sellers, Chairperson, Room 25, San Diego Convention Center, p. 146 8:00 a.m.-10:00 a.m. Educational Sessions Speakers: Thomas A. Sellers, Lorelei A. Mucci, Simon A. Gayther, Peter Kraft Beyond Ipilimumab and PD1/PD-L1 Pathway Blockade: Next Generation of Immunomodulatory PI3K-mTOR/PTEN , Ramon E. Parsons, Chairperson, Antibodies , Mario Sznol, Chairperson, Room 33, Room 31, San Diego Convention Center, p. 146 San Diego Convention Center, p. 143 Speakers: Lewis C. Cantley, Bart Vanhaesebroeck, John Speakers: Mario Sznol, Ana C. Anderson, Drew M. Blenis, Ramon E. Parsons Pardoll, Andrew D. Weinberg Targeting RhoGTPases and Their Kinase Effectors , Cancer Metabolism , Chi V. Dang, Chairperson, Jonathan Chernoff, Chairperson, Room 1, San Diego Room 6CF, San Diego Convention Center, p. 143 Convention Center, p. 146 Speakers: Chi V. Dang, Joshua D. Rabinowitz, Matthew Speakers: Jonathan Chernoff, Nupam P. Mahajan, G. Vander Heiden, Teresa W. M. Fan Cristina Fernandez-Valle, Michael F. Olson Drugging the Cell Cycle in Cancer , Geoffrey I. Shapiro, Tumor Immunology and Immunotherapy for Non- Chairperson, Room 7, San Diego Convention Center, Immunologists , Michael A. Caligiuri, Chairperson, p. 144 Ballroom 20D, San Diego Convention Center, p. 147 Speakers: Geoffrey I. Shapiro, David D. L. Bowtell, Alan Speakers: Robert A. Baiocchi, Lisa M. Coussens, Jeffrey Eastman, Wenyi Wei A. Sosman, Crystal L. Mackall Evolving Tumor Cell Populations: Dealing with Diversity , Nicholas E. Navin, Chairperson, Room 11, San Diego Convention Center, p. -
An ASBMB History May 2009
UAN ANNOUNCES 2009 AWARD WINNERS An ASBMB History May 2009 American Society for Biochemistry and Molecular Biology contents MAY 2009 ON THE COVER: ASBMB unveils its society news new history book. 12 3 President’s Message 6 Washington Update 7 Showcasing the National Science Foundation 12 The First Hundred Breast Cancer Years Are the Hardest Biomarkers 16 Premiering in May: 27 A New JLR Thematic Review Series on Proteomics special interest 14 Power to the Postdocs science focus 28 Benjamin Neel: Phosphatases and Disease departments 2 Letters to the Editor 8 News from the Hill 10 Member Spotlight 17 Lipid News 18 Education and Training 22 Minority Affairs Benjamin Neel studies phosphatases and disease. 28 24 Career Insights 26 BioBits resources podcast summary Scientific Tune into this month’s podcasts and hear Meeting interviews with the authors of the JBC thematic Calendar minireview series “Metals in Biology” and “The Biochemical Basis for Triplet Repeat online only Neurodegenerative Diseases.” You can listen to the podcasts at www.asbmb.org/Interactive.aspx May 2009 ASBMB Today 1 letter to the editor A monthly publication of The American Society for tive yet informal and that the views Biochemistry and Molecular Biology Facts and expressed by the speakers are their Officers Gregory A. Petsko President own thoughts and perceptions Heidi E. Hamm Past President Fictions on matters of interest. In regard Mark A. Lemmon Secretary Dear ASBMB, Merle S. Olson Treasurer to the specifics of the question, I Rewriting history is an unsa- Council Members have carefully looked over Norum’s Dafna Bar-Sagi Alan Hall John D. -
Table of Contents (PDF)
December 16, 2014 u vol. 111 u no. 50 u 17685–18090 Cover image: Pictured is an illustration of the crystal structure within a Frank–Kasper σ-phase formed by an asymmetric diblock copolymer. Competition between the tendency to form spherical core-shell micelles and the requirement to fill space without voids leads to five discrete polyhedral-shaped particles, depicted with different colors, which pack into a low-symmetry crystal structure. Sangwoo Lee et al. found that the breaking of higher sym- metry structure that leads to formation of a Frank–Kasper σ-phase occurs through a transfer of mass in this polymer system, suggesting that similar symmetry breaking in intermetallic alloys may occur through a transfer of charge. The results suggest analogies between phase transitions in disparate material classes and challenge the view that the formation of reduced symmetry structures requires particles with predetermined shapes or sizes. See the article by Lee et al. on pages 17723–17731. Image courtesy of Sangwoo Lee. From the Cover 17723 Breaking symmetry E5346 Recognizing African plants in the New World 17743 Archaeological wood conservation 17783 Identity fusion among revolutionaries 17977 Melanopsin and vascular photorelaxation Contents SCIENCE AND CULTURE—How science intersects with culture 17687 Science and Culture: Capturing the world’s oldest living things Helen Fields THIS WEEK IN PNAS 17685 In This Issue INNER WORKINGS—An over-the-shoulder look at scientists at work 17688 Inner Workings: A soft robot that swims like a fish LETTERS (ONLINE ONLY) Stephen Ornes E5331 Population matters when modeling hurricane fatalities Laura A. Bakkensen and William Larson RETROSPECTIVE E5333 Reply to Bakkensen and Larson: Population may matter but does not alter conclusions 17689 Robert Steinberg, 1922–2014 Kiju Jung, Sharon Shavitt, Madhu Viswanathan, V. -
February 2018 Asbmb Today 1 Editor’S Note
CONTENTS NEWS FEATURES PERSPECTIVES 2 20 35 EDITOR’S NOTE SIX QUESTIONS MEETINGS Reclaim inspiration FOR THREE PRESIDENTS ASBMB to host symposium on transcriptional regulation 3 26 NEWS FROM THE HILL ADDRESSING THE TANGLED ROOTS 36 The NIH is cruising — WHEN SCIENCE MEETS SICKNESS OF HEALTH DISPARITIES now let’s boost the NSF From a personal disease to a personal research project 4 20 NEWS Three college 38 Member update and university presidents from ESSAY underrepresented Raising a rainbow of scientists groups talk about 10 how a background LIPID NEWS in science serves 42 Back to the (poly)basics — them at the helm. RESEARCH SPOTLIGHT lipin enzyme phosphoregulation From back-porch evolution 12 to learning slang at the bench JOURNAL NEWS 26 12 New insights into treating 38 amoebic keratitis 13 When mitochondria make B cells go bad 14 Sugary secrets of a cancer-related protein 15 Scientists find cellular backup plan for keeping iron levels just right 16 From the journals 13 16 36 WHEN SCIENCE MEETS SICKNESS FEBRUARY 2018 ASBMB TODAY 1 EDITOR’S NOTE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Reclaim inspiration By Comfort Dorn OFFICERS COUNCIL MEMBERS Natalie Ahn Squire J. Booker President Victoria J. DeRose Wayne Fairbrother ack when Juliette Bell was a dential tweet. And I have to admit Gerald Hart Rachel Green President Elect Blake Hill chemistry professor, she shared that Coates is right. It’s a perilous her concerns about a lack of thing to be an American of color. Jennifer DuBois Susan Marqusee B Secretary Celia A. -
HHMI Bulletin May 2009 Vol. 22 No. 2
HHMI BULLETIN M AY ’09 VOL .22 • NO.02 4000 Jones Bridge Road • Chevy Chase, Maryland 20815-6789 Howard Hu www.hhmi.org BULLETIN g hes Medical Institute HHMI In the Eye of the Beholder This isn’t a pansy or a poppy blossom. It’s a mouse retina, removed and flattened to • show the entire surface of the tissue. The concentrated red staining at the top of the image www.hhmi.or indicates that the cone photoreceptors of the dorsal retina contain high levels of phos- phorylated mTOR protein. Phosphorylation of mTOR is a sign that the cells are healthy and receiving good nutrition. This finding suggests a couple of possi bilities, according to HHMI investigator Connie Cepko. First, dorsal cones may respond differently to their surrounding environment than ventral cones. Or the nutrient supply, oxygen level, and g environmental interactions may differ around the dorsal and ventral cones. Understanding normal cone photoreceptor behavior will help Cepko’s team figure out what goes wrong when cone cells die, as in the sight-robbing disease retinitis pigmentosa (see page 12). DETANGLING DNA ProtEINS CALLED HIStoNES HELP MAINTAIN vol. NuCLEAR OrdER. 22 /no. IN THIS ISSUE Early Career Scientists Claudio Punzo / Cepko lab Mathematic Modeler Mercedes Pascual 02 Science Posse OBSERVATI O NS 49 This array of shells shows obvious variety in shape, color, and size. But another quality can be used to categorize the shells: whether they are dextral (right- coiling), or sinsitral (left-coiling). Their left-right asymmetries can be traced to the same genes that affect which side of the human body different organs are found on, researchers have found. -
Life the Universe Breakthrough Initiatives Introduction BREAKTHROU GHINITIATIVE S
Life the Universe Breakthrough Initiatives Introduction BREAKTHROU GHINITIATIVE S Pete5/21/2018 Klupar, BREAKTHROUGH PRIZE FOUNDATION CHIEF ENGINEER - [email protected] – 11 April 2018 2018 Breakthrough Prize Winners 2018 Breakthrough Prizes in Life Sciences Awarded: Joanne Chory, Don W. Cleveland, Kazutoshi Mori, Kim Nasmyth, and Peter Walter. New Horizons in Physics Prizes Awarded; 2018 Breakthrough Prize in Physics Awarded; Christopher Hirata, Douglas Stanford, and Charles L. Bennett, Gary Hinshaw, Norman Jarosik, Andrea Young. ($100,000) each Lyman Page Jr., David N. Spergel, and the WMAP Science Team New Horizons in Mathematics Prizes Awarded; Aaron Naber, Maryna Viazovska, Zhiwei Yun, and 2018 Breakthrough Prize in Mathematics Awarded; Wei Zhang. (7) ($300,000) each Christopher Hacon and James McKernan. (13) 3 5/21/2018 Breakthrough Junior Challenge 2016 2016 2017 Hillary Diane Andales. Submit application and video no later than July 1, 2018 at 11:59 PM Pacific Daylight Time Ages 13 to 18 $250K Scholarship $100K Lab $50K Teacher 2015 Ryan Chester Ohio 4 5/21/2018 5/21/2018 5 6 BTW 10um : current and future capabilities Watch VLT only survey, current camera: Can detect ~2 Earth radius rocky planets = ~10 Earth mass in Alpha Cen A&B system Full survey (VLT, Gemini, Magellan), new detector: -detector alone brings 4x gain in efficiency (same observation requires ¼ of the time). At equal exposure time, 2x gain in sensitivity: from 2 Earth radius / 10 Earth mass to 1.4 Earth radius / 3 Earth mass -Gemini and Magellan increases