WASL Polyclonal Antibody

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PRODUCT DATA SHEET Bioworld Technology,Inc. WASL polyclonal antibody Catalog: BS91449 Host: Rabbit Reactivity: Human, Mouse BackGround: Storage&Stability: This gene encodes a member of the Wiskott-Aldrich syn- Store at +4°C after thawing. Aliquot store at -20°C or drome (WAS) protein family. Wiskott-Aldrich syndrome -80°C. Avoid repeated freeze / thaw cycles. proteins share similar domain structure, and associate Specificity: with a variety of signaling molecules to alter the actin WASL polyclonal antibody detects endogenous levels of cytoskeleton. The encoded protein is highly expressed in WASL protein. neural tissues, and interacts with several proteins in- DATA: volved in cytoskeletal organization, including cell divi- sion control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to Western blot analysis of WASL on mouse Human serum lysates using HSF1/HSTF1 and forms a complex on heat shock pro- anti-Ubiquitin antibody at 1/500 dilution. moter elements (HSE) that negatively regulates HSP90 expression.. Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Molecular Weight: 55 kDa Swiss-Prot: ICC staining WASL in SK-Br-3 cells (green). The nuclear counter stain O00401(Human) Q91YD9(Mouse) is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised Purification&Purity: with 0.25% Triton X100/PBS. ProA affinity purified Note: Applications: For research use only, not for use in diagnostic procedure. WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 Bioworld Technology, Inc. Bioworld technology, co. Ltd. Add： 1660 South Highway 100, Suite 500 St. Louis Park, Add： No 9, weidi road Qixia District Nanjing, 210046, MN 55416,USA. P. R. China. Email: [email protected] Email: [email protected] Tel: 6123263284 Tel: 0086-025-68037686 Fax: 6122933841 Fax: 0086-025-68035151 .

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Regulation of Cdc42 and Its Effectors in Epithelial Morphogenesis Franck Pichaud1,2,*, Rhian F
© 2019. Published by The Company of Biologists Ltd | Journal of Cell Science (2019) 132, jcs217869. doi:10.1242/jcs.217869 REVIEW SUBJECT COLLECTION: ADHESION Regulation of Cdc42 and its effectors in epithelial morphogenesis Franck Pichaud1,2,*, Rhian F. Walther1 and Francisca Nunes de Almeida1 ABSTRACT An overview of Cdc42 Cdc42 – a member of the small Rho GTPase family – regulates cell Cdc42 was discovered in yeast and belongs to a large family of small – polarity across organisms from yeast to humans. It is an essential (20 30 kDa) GTP-binding proteins (Adams et al., 1990; Johnson regulator of polarized morphogenesis in epithelial cells, through and Pringle, 1990). It is part of the Ras-homologous Rho subfamily coordination of apical membrane morphogenesis, lumen formation and of GTPases, of which there are 20 members in humans, including junction maturation. In parallel, work in yeast and Caenorhabditis elegans the RhoA and Rac GTPases, (Hall, 2012). Rho, Rac and Cdc42 has provided important clues as to how this molecular switch can homologues are found in all eukaryotes, except for plants, which do generate and regulate polarity through localized activation or inhibition, not have a clear homologue for Cdc42. Together, the function of and cytoskeleton regulation. Recent studies have revealed how Rho GTPases influences most, if not all, cellular processes. important and complex these regulations can be during epithelial In the early 1990s, seminal work from Alan Hall and his morphogenesis. This complexity is mirrored by the fact that Cdc42 can collaborators identified Rho, Rac and Cdc42 as main regulators of exert its function through many effector proteins.
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4036.Full.Pdf
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