Argan Oil Dom Guillaume, Phd; Zoubida Charrouf, Phd
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Monograph amr Argan Oil Dom Guillaume, PhD; Zoubida Charrouf, PhD Introduction Argan oil has sky-rocketed from a mere Argania spinosa – Argan tree and seeds tourist attraction to one of the most prized oils in the world in a few short years. Argan oil’s unique savor and multiple pharmaco- logical properties are responsible for this success. Argan oil is almost exclusively produced in southwestern Morocco, one of the poorest parts of the country, where all-women cooperatives specialize in high quality argan oil extraction. !is activity is therefore providing a welcome "nancial stream. However, the argan tree, the fruit of which provides argan oil, could rapidly become an endangered species due to years of recurrent drought, forest overuse, and poor forest management. Consequently, such as the use of electric screw-presses, have women cooperatives aimed at sustainably support- allowed the discontinuation of the hand-malaxing ing the argan forest represent the cornerstone of a step, resulting in as much as 60-percent extraction vast program involving the reforestation of fragile yield.3 Even more recent technology permits the and particularly degraded lowlands and also large-scale production of virgin4 argan oil, without provide education of rural women. denaturing its quality,5 while preserving the 6 Argan Tree and Argan Oil sustainable development of the argan forest. Argan oil is principally produced as edible and !e argan tree (Argania spinosa (L.) Skeels; beauty grades. A third grade referred to as cosmetic Sapotaceae) is a slow-growing tree exclusively oil also exists. Virgin edible argan oil is prepared Dom Guillaume, PhD – School endemic to the barren lands of southwest of Medicine-Pharmacy, from slightly and carefully roasted kernels.7 It is Morocco.1 It is currently considered a relic of the University of Reims copper-colored, presents a slight hazelnut taste, Champagne-Ardenne, Reims, tertiary era and is the only member of the and is the basic ingredient of the Amazigh diet.8 France. Sapotaceae family of plants whose distribution is Correspondence address: Virgin beauty argan oil, that is prepared from not intertropical. !e argan forest, which covers Departement of Medicinal unroasted kernels, is golden-colored and has no Chemistry, 51 rue Cognacq Jay, about 8,280 km2, was declared a Biosphere Reserve taste. Virgin edible argan oil presents a better 51100 Reims, France. by UNESCO in 1998. Traditionally, Amazigh (argan Email: dominique. long-term preservation pro"le than virgin beauty forest native) women used the kernels of argan [email protected] argan oil. At 25°C, the former preserves its quality fruit stones as a source of edible oil. Oil extraction for up to two years, while the shelf life of the latter Zoubida Charrouf, PhD – requires a tedious multistep process that begins University MohammedV- is only 3-4 months.9 Virgin edible and beauty argan with careful fruit drying2 and involves prolonged Agdal, Morocco; oils are produced in Moroccan women cooperatives, professor, Laboratory of Plant hand-malaxing of an aqueous argan kernel dow,3 and their world-wide marketing actively contrib- Chemistry with an extraction yield up to 35 percent. utes to the argan forest sustainable development. Improvements in argan oil extraction methodology, 275 Alternative Medicine Review Volume 16, Number 3 Copyright © 2011 Alternative Medicine Review, LLC. All Rights Reserved. No Reprint Without Written Permission. amr Monograph Key words: argan oil, Cosmetic argan oil is industrially prepared, mostly Tocopherols are molecules with strong antioxi- Argania spinosa, oleic acid, in Europe, by solvent extraction of imported dant and free radical scavenging properties. monounsaturated fatty acid, kernels. Cosmetic argan oil is only used as an gamma-Tocopherol, the most e%cient free radical MUFA, sebum, cholesterol, 16 hyperlipidemia, diabetes, ingredient for the preparation of shampoos, scavenger of all tocopherols, composes 69 percent antiproliferative, cancer, moisturizers, and industrial cosmetic products.10 of argan oil total tocopherol content.15 Because cosmetic Traditionally, argan oil was used extensively in tocopherols and sterols can act synergistically, the Morocco as a topical oil to treat various ailments, speci"c combination of molecules found in the such as dry skin, acne, psoriasis, eczema, wrinkles, unsaponi"able matter is theorized to contribute to joint pain, and skin in#ammation.11 It is also used the therapeutic aspects of argan oil.17 to prevent hair loss and dry hair.11 Ingested, argan oil is a choleretic and hepatoprotective agent that Mechanisms of Action/Clinical Activity can prevent hypercholesterolemia and Topical and oral argan oils have di$erent atherosclerosis.11 therapeutic properties (Figure 1). Cosmetic properties attributed to topical (beauty) oil are Biochemical Constituents primarily based on traditional claims and have Virgin argan oil of edible or beauty grade is little scienti"c backing. Properties of virgin edible composed of 99-percent acylglycerides (primarily argan oil have been evaluated in animal models and triglycerides).11 Unsaponi"able matter, which human cohort studies. represents the remaining one percent, is composed of carotenes, tocopherols, triterpene alcohols, Anti-sebum Activity sterols, and xanthophylls.11 Fatty acids that Argan oil-containing creams are frequently compose acylglycerides are principally oleic and indicated in cosmetology as moisturizing, linoleic acid, 43-49 percent and 29-36 percent, respectively.12 Oleic acid is a monounsaturated fatty acid of the Figure 1. Therapeutic Properties of Argan Oil omega-9 family, while linoleic acid is a polyunsaturated fatty acid belonging to the omega-6 family. Palmitic and stearic acid are saturated fatty acids W found at a concentrations of 11-15 ound healer percent and 4-7 percent, respectively.12 Moisturizing Some argan oil pharmacological properties are likely to result from its high unsaturated fatty acid content. Oleic acid, a monounsaturated fatty Anti-acne acid, has numerous therapeutic e$ects13 that contribute to the impor- Anti-aging tant properties of argan oil. Because a Anti-sebum linoleic acid de"ciency can induce poor BEAUTY wound healing,14 the high linoleic acid content of argan oil may contribute to e EDIBLE its traditional indication as a cure for tiv Choleretic skin in#ammation. However, several Hepatoprotec other oils are rich in oleic and/or linoleic acid but do not possess the e Anti- same therapeutic e$ects. Many of obesit argan oil’s speci"c health bene"ts are diabetic attributed to its composition of Anti- y unsaponi"able matter (although it constitutes a small amount of the oil) and high tocopherol content.15 !e tocopherol content of argan oil is 620 Anti-proliferativ mg/kg, compared to 320 mg/kg in olive oil. Copyright © 2011 Alternative Medicine Review, LLC. All Rights Reserved. No Reprint Without Written Permission. Volume 16, Number 3 Alternative Medicine Review 276 Monograph amr anti-aging, and repair creams. !e anti-sebum signal-regulated kinases 1 and 2 (ERK1/2) to activity of topical argan oil was demonstrated on respond to increasing doses of insulin, while the 20 17- to 50-year-old volunteers with oily facial response to serine/threonine kinase (Akt) skin. Sebum level was determined on forehead and remained undisturbed.25 Argan oil polyphenols also both cheeks. A twice daily facial application of an interrupt the insulin-signaling cascades at the argan oil-containing cream for four weeks revealed MEK1/2-ERK1/2 interface.25 signi"cant anti-sebum activity that translated to reduced greasiness and improved appearance of Cardiovascular/Lipid E!ects oily facial skin.18 Treatments longer than four Phenolics26 and phytosterols27 possess direct or weeks did not show improved sebum-regulating indirect hypocholesterolemic activity. Rat studies e%cacy. demonstrate the hypolipidemic and hypotriglyceri- demic e$ect of argan oil.28 Another study showed Antiproliferative Activity/Cancer Preventive that the phenolic fraction of argan oil prevents Epidemiological data have indicated that regular low-density lipoprotein (LDL) cholesterol oxidation consumption of edible olive oil could have signi"- in isolated human plasma and enhances reverse cant protective e$ects against colorectal, breast, cholesterol transport by increasing high-density prostate, pancreas, and endometrial cancer.19 !e lipoprotein (HDL) cholesterol levels.29 combined presence in olive oil of oleic acid, pheno- A human cohort study provides evidence for the lics endowed with antioxidant properties, and hypolipidemic activity of argan oil.30 During this squalene is currently considered to be the key strict lipid-controlled study, 60 men were "rst fed factor to explain this antiproliferative activity.20 25 g/day of butter on toasted bread as a source of Because argan and olive oils have these essential lipids for two weeks in order to establish baseline constituents in common, an antiproliferative e$ect conditions. !en, butter was replaced by 25 mL/ has been claimed for argan oil.21 day of virgin argan oil for one half of the group, !e antiproliferative activity of argan oil unsa- while the other half received the same amount of poni"able matter, mainly polyphenols, tocopherols, virgin olive oil; otherwise, a similar diet was given and sterols, has been studied in vitro on hormone- to both groups. After three weeks, participants independent (DU145 and PC3), hormone-depen- underwent medical examination and parameters dent (LNCaP), and SV40-immortalized prostate such as body mass index (BMI), systolic and tumor cell lines.22,23 Sterols from argan oil appear diastolic blood pressure (SBP and DBP, respec- to have particularly strong antiproliferative activity tively), serum total cholesterol, HDL, LDL, apolipo- against PC3 cell line; whereas, polyphenols display proteins A-I and B, and triglyceride levels were a high activity against DU145 and LNCaP cell lines. measured and compared with baseline values. BMI, !e precise mechanism of action as an antiprolif- SBP, DBP, and total cholesterol levels did not erative agent is still poorly understood. Cell cycle signi"cantly change during the three-week study.