Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000753795Cyc: Shewanella mangrovi YQH10 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

molybdate phosphate phosphate

PstC RS04785 RS08110 FtsX GspE RS18465 FliL RS02695 RS05740 ModC RsxB RS12030 SohB FliG FliM FliQ FlhF RS02410 RS02250 RS10010 RS15620 LptG RS01680 RS01605 MurJ RS02400 RS01330 RS11775 RS06520 RS11750 RS08505 FlhB RS00580 RS09545 LptC CrcB RS06405 RS14070 RS14040 FliG RS08485 RS08495 RS00745 RS15365 RS01080 MotA RS11785 RS09655 CcmD RS19200 YajC BrnQ TrkA ArsB RS02180 RS05465 NrfE FlhB FliO FliJ FliF TolR RS10365 ZipA RS06935 RS05785 RS12390 GspL RS03340 RS03595 RS06070 RS07340 RS16385 UbiB PstB PstB

molybdate phosphate phosphate

LolA RS14075

6 Tetrapyrrole Biosynthesis N -(3-methylbut- ditrans,octacis- a peptidoglycan with 3-phenyl-2- ditrans,octacis- ditrans,octacis- a [bis(guanylyl UDP-N-acetyl- (4R)-4-hydroxy- a [protein]-L- a [protein]-L- a [protein] Cofactor, Carrier, and Vitamin Biosynthesis a sulfurated a lipid II MoO - a uracil in DNA a nucleoside 5 an L-asparaginyl- NADPH NAD + biotin biosynthesis I Fermentation 2-en-1-yl)- undecaprenyldiphospho- (L-alanyl-γ-D-glutamyl- tyr undecaprenyldiphospho- undecaprenyldiphospho- molybdopterin) cys α-D-muramoyl- 2 RNA glutamate-O C-terminal glu superpathway of menaquinol-8 biosynthesis I acyl carrier guanylyl molybdenum ubiquinol-8 biosynthesis NADP flavin biosynthesis I (bacteria and plants) FeMo cofactor biosynthesis molybdenum cofactor biosynthesis tetrahydromonapterin mixed acid fermentation [sulfur carrier] oxopropanoate 2-oxoglutarate ATP triphosphate methionine [tRNA Asn ] ubiquinol-8 biosynthesis superpathway of heme b biosynthesis from uroporphyrinogen-III superpathway of pyrimidine Nucleoside and Nucleotide Degradation adenosine 37 N-acetyl-(N-acetyl-β-D- L-lysyl-D-alanyl-D- N-acetyl-(N- N-acetyl-(N- cofactor L-alanyl-γ-D- molybdopterin -methyl-ester peptide- L-glutamate LptA FliD protein activation cofactor biosynthesis (late decarboxylation) biosynthesis biosynthesis superpathway of purine deoxyribonucleosides degradation (early decarboxylation) tetrapyrrole biosynthesis siroheme biosynthesis deoxyribonucleosides degradation in tRNA glucosaminyl)muramoyl- alanine) pentapeptide acetylglucosaminyl) acetylglucosaminyl) chaperone]- glutamyl-meso-2,6- cofactor methionine a malonyl-[acp] MoO - a [4Fe-4S] iron- I (from glutamate) phosphoenolpyruvate penicillin- bifunctional uracil-DNA chorismate an apo acyl- all-trans- 2 chorismate + molybdate L-alanyl-γ-D-glutamyl-L- aspartate/ muramoyl-L-alanyl-γ- muramoyl-L-alanyl-γ-D- L-cysteine diaminopimeloyl- DNA- (S)-S-oxide malonyl-ACP O- molybdopterin NAD GTP sulfur cluster uroporphyrinogen-III 2'-deoxycytidine binding 4-hydroxy-2- glycosylase: chemotaxis 30S aminoacyl- carrier protein 4-hydroxybenzoate octaprenyl NAD(+) uroporphyrinogen-III tRNA (N6-isopentenyl lysyl-D-alanyl-D-alanine tyrosine/aromatic D-isoglutaminyl-N-(β- isoglutaminyl-L-lysyl- D-alanyl-D-alanine molybdenum cofactor directed RNA reductase methyltransferase isochorismate holo-ACP cofactor molybdenum cofactor molybdenum GTP 2'-deoxyguanosine protein oxoglutarate ung response ribosomal tRNA diphosphate kinase: glu uroporphyrin-III pyruvate kinase: pyk phosphoenolpyruvate cytidine adenosine(37)-C2)- aminotransferase: D-asparaginyl)-L-lysyl- (glycyl) -D-alanyl-D-alanine guanylyltransferase: polymerase: regulator protein- MsrA: msrA BioC: bioC synthase: synthase: guanylyltransferase: ABC GTP uroporphyrinogen 5 cysteine 2: mrdA aldolase/2- protein hydrolase: RS14185 RS06560 a malonyl-[acp] nadK bifunctional molybdopterin methyltransferase: carboxylase: ppc 2'-deoxyadenosine methylthiotransferase HR45_RS02745 D-alanyl-D-alanine mobA uracil-DNA rpoC rpoB HR45_RS08935 HR45_RS07245 4-hydroxybenzoate guanylyl mobA all-trans- transporter cyclohydrolase decarboxylase: hemE glutamate-- deaminase: monofunctional desulfurase penicillin- D-alanyl-D-alanine dehydro-3-deoxy- glutamate bifunctional S6--L- pth methyl ester a holo acyl- + 3,4-dihydroxy- MiaB: miaB glycosylase: + molybdenum NADP a NifB protein I FolE: folE tRNA ligase: gltX HR45_RS12620 cdd thymidine biosynthetic aspartate/ monofunctional [+ 3 isozymes] methylesterase: methionine glutamate NADH NADP carrier protein octaprenyltransferase: 4-hydroxybenzoate octaprenyl 2-butanone-4- ATP-binding molybdopterin 7,8-dihydroneopterin pyruvate NifS: nifS binding carboxypeptidase/ phosphogluconate ung aminoacyl- beta-ketoacyl- isochorismate coproporphyrinogen III Glu [+ 2 isozymes] pyrimidine/purine succinate tyrosine/aromatic adenylyl HR45_RS13515 sulfoxide ubiA cofactor diphosphate with a K-cluster protein adenylyltransferase: 3'-triphosphate an L-glutamyl-[tRNA ] oxaloacetate peptidoglycan monofunctional biosynthetic [+ 2 isozymes] protein D-alanyl-D-alanine- aldolase: eda ligase: rimK tRNA ACP synthase phosphate synthase/ precorrin-1 2'-deoxyuridine pyrimidine/purine adenosine nucleoside dehydrogenase, aminotransferase: molybdenum reductase ModC: modC mog transglycosylase: biosynthetic peptidoglycan 2: mrdA endopeptidase: dacB hydrolase: I: fabB 2-succinyl-6- GTP cyclohydrolase dihydroneopterin malate nucleoside deaminase: phosphorylase: hydrophobic HR45_RS10860 cofactor an apyrimidinic uracil RNA B/A protein: RS01160 FlgL 4-hydroxy-3- 4-hydroxybenzoate oxygen-independent oxygen-dependent glutamyl-tRNA uroporphyrin-III formate C- mtgA peptidoglycan transglycosylase: a [bis(guanylyl α a [protein] C- arfB hydroxy-2, 4- II: HR45_RS18030 molybdopterin triphosphate 2'- dehydrogenase: phosphorylase: add HR45_RS08435 membrane anchor D-alanyl-D-alanine site in DNA MeOH a [protein]- - HR45_RS04300 beta-ketoacyl- octaprenylbenzoate octaprenyltransferase: molybdate coproporphyrinogen coproporphyrinogen reductase: hemA methyltransferase: acetyltransferase: pflB transglycosylase: mtgA ala molybdopterin) glyoxylate pyruvate terminal α-L- cyclohexadiene- GTP cyclohydrolase adenine dinucleotide epimerase: folX HR45_RS11295 HR45_RS08435 purine-nucleoside protein: sdhD 3-(4- carboxypeptidase/ a N- L-glutamate a protein-L- ACP synthase UbiD family ubiA a NifB protein III oxidase: hemN oxidase: hemF HR45_RS12620 a peptidoglycan with di-trans,octa-cis mtgA cofactor D-alanyl-D-alanine- methionine- glutamate-α- 1-carboxylate II: ribA 7,8-dihydromonapterin (R)-lactate [+ 2 isozymes] thymidine pyrimidine/purine phosphorylase: hydroxyphenyl) phe D-ala acetylglucosamine- II: fabF with an L-cluster (S)-4-amino-5-oxopentanoate 6 (L-alanyl-γ-D-glutamyl- -undecaprenyl a peptidoglycan di-trans,octa-cis chaperone]-S- L-glutamate Asn synthase: menH decarboxylase: bifunctional triphosphate [+ 2 isozymes] formate acetyl-CoA nucleoside 2'-deoxyinosine deoD N -(3-methylbut- pyruvate endopeptidase: dacB -N-acetylmuramyl- (S)-S-oxide asn tRNA RS01350 FlgK 4-hydroxy-3- 2,5-diamino-6-(5-phospho-D- phosphorylase: 5'-deoxyadenosine an unsulfurated L-lysyl-D-alanyl-D- diphosphate di-trans,octa-cis dimer (S. aureus) -undecaprenyl sulfanyl-L-cysteine a 3-oxoglutaryl- HR45_RS00530 nitrogenase molybdopterin- protoporphyrinogen IX protoporphyrinogen IX glutamate-1- (S)-malate pyrimidine/purine phosphorylase: 2-en-1-yl)-2- met a peptidoglycan (tetrapeptide) 2-succinyl-5- octaprenylbenzoate ribosylamino)pyrimidin-4(3H)-one phosphopantothenate biosynthesis I precorrin-2 deoA [sulfur carrier] alanine) pentapeptide -undecaprenyl diphosphate [acp] methyl ester 4-hydroxy-3- iron- guanine dinucleotide semialdehyde 2,1- nucleoside HR45_RS08435 (methylsulfanyl) dimer (E. faeciums) UDP-N- pyrophosphoryl- enolpyruvyl- 4-hydroxy-3- bifunctional 37 polyprenylbenzoate phosphate bifunctional 2-methylcitrate fumarate hydratase: phosphorylase: thymine adenosine diphosphate D-ala acetylmuramoyl- undecaprenol 3-oxoacyl- 6-hydroxy-3- octaprenylbenzoate diaminohydroxyphosphoribosylaminopyrimidine molybdenum biosynthesis 2-methyladeninyl adenosylcobamide aminomutase: hemL bifunctional purine-nucleoside pyrimidine/purine decarboxylase: ubiD D-threo-7,8- menaquinone- menaquinone- acetyltransferase: pta acetaldehyde- synthase: prpC HR45_RS03200 HR45_RS08435 purine nucleotides degradation II (aerobic) in tRNA L-alanyl-γ-D- ACP cyclohexene- 5-hydroxylase: ubiH deaminase/5-amino-6-(5-phosphoribosylamino) cofactor adaptor protein biosynthesis from adenosylcobinamide-GDP 3-methyl-2-oxobutanoate precorrin-2 phosphorylase: nucleoside superpathway of D-ribulose 5-phosphate pyridoxal 5'-phosphate biosynthesis I dihydroneopterin dependent dependent 5-aminolevulinate CoA/alcohol citrate synthase: [+ 2 isozymes] glutamyl-meso-2,6- RS06585 FliD reductase 1-carboxylic- 3,4-dihydroxy- uracil reductase RibD: ribD biosynthesis MobB/molybdopterin dehydrogenase/ CO H uridine deoD phosphorylase: 2-octaprenylphenol demethylmenaquinol-8 biosynthesis I 3-methyl-2-oxobutanoate protoporphyrinogen IX protoporphyrinogen IX 2 2 dehydrogenase: adhE FabG: fabG protein molybdotransferase sirohydrochlorin HR45_RS05150 fumarate phosphorylase: HR45_RS08435 diaminopimeloyl- acid synthase: 5-all-trans- bifunctional 5-amino-6-(5-phospho- D-erythrose 2-methyladenine hydroxymethyltransferase: dihydromonapterin NAD salvage pathway I (PNC VI cycle) dehydrogenase: hemG dehydrogenase: hemG porphobilinogen acetyl phosphate NifE: nifE MoeA: HR45_RS18630 ferrochelatase: udp purine-nucleoside AMP D-alanine 3-oxoacyl- HR45_RS09125 chorismate octaprenylbenzoate 3,4-dihydroxy- D-ribosylamino)uracil 4-phosphate panB reductase: folM synthase: hemB molybdopterin nicotinate-nucleotide-- [+ 2 isozymes] [+ 2 isozymes] HR45_RS11805 acetate kinase: acetaldehyde citrate succinate phosphorylase: ACP 2-succinyl-5- 2-butanone-4- nitrogenase 5,6,7,8- + bifunctional erythrose-4- dimethylbenzimidazole NAD dehydrogenase/ pyrimidine 5'- γ γ RS09935 RS13665 reductase enolpyruvoyl- 3-(all-trans isochorismate iron- molybdenumtransferase: 2-dehydropantoate porphobilinogen HR45_RS05305 deoD an inactive a [DNA]-3'- a 5'-phospho- ditrans,octacis- L-alanyl- -D- L-alanyl- -D- DNA with adenine:7,8- a 2,3,4-saturated phosphate synthase/ diaminohydroxyphosphoribosylaminopyrimidine tetrahydromonapterin sirohydrochlorin bifunctional a reduced + phosphoenol an L-cysteinyl- FabG: fabG synthase: phosphate HR45_RS09250 phosphoribosyltransferase: bifunctional fumarate reductase nucleotidase: yjjG ribonucleoside SAM adenosylcobinamide a purine NAD glutamyl-meso-2,6- glutamyl-meso- UDP-N-acetyl- a [glutamine- dihydro-8- 1,2-diacyl-sn a RNA-DNA hybrid L-cysteate a protein a protein 6-hydroxy-3- -octaprenyl) 3-methoxy-4- GTP cyclohydrolase molybdenum 2-deoxy-α-D- hydroxyl [DNA] undecaprenyldiphospho- ATP pyruvate ATP roseoflavin Cys deaminase/5-amino-6-(5-phosphoribosylamino) dehydrogenase: cobT 2-dehydropantoate 2- ammonia- acetaldehyde- aconitate hydratase iron-sulfur: frdD frdC flavodoxin ribonucleoside α synthetase]- dGDP ATP [tRNA ] a (3R)-3- cyclohexene- benzene-1,2-diol HR45_RS08935 cofactor hydroxymethylbilane acetate [+ 3 isozymes] IMP triphosphate N-acetyl-(N- diaminopimeloyl- UDP-N-acetyl- diaminopimelate -D-muramate oxoguanine mismatch -glycerol 3- aspartate/ ATP-dependent biotin hydroxy-5-all-trans II: HR45_RS18030 uracil reductase RibD: ribD epd reductase: HR45_RS16000 dependent NAD(+) bifunctional CoA/alcohol 2/2-methylisocitrate HR45_RS10505 frdA ribose 1-phosphate 5'-triphosphate L-tyrosine 5'-phosphate carboxy hydroxyglutaryl- 1-carboxylate bifunctional 2- biosynthesis MoO -molybdopterin ammonia- synthase: hemC uracil 2-deoxy-α-D- GMP reductase acetylglucosaminyl) D-alanine α-D-muramate phosphate CTP tyrosine/aromatic Clp protease isochorismate -octaprenylbenzoate 3,4-dihydroxy- 5-amino-6-(5-phospho- 4-phospho- 2 2-methyladenine 2-dehydropantoate 2- synthetase: nadE precorrin-2 dehydrogenase: adhE dehydratase: acnB phosphopentomutase: DNA ligase: ribonuclease terminal- [acp] methyl ester 2-succinyl-6- polyprenyl-6- protein 2-oxoglutarate cofactor dependent NAD(+) fumarate reductase: ribose 1-phosphate adenosine IMP muramoyl-L-alanyl- A/G-specific aminotransferase: ATP-binding RS11275 RS13670 2-butanone- D-ribitylamino)uracil D-erythronate adenosylcobinamide- ribotide phosphate reductase: HR45_RS08410 preuroporphyrinogen dehydrogenase/ HR45_RS12820 bifunctional HR45_RS04320 UDP-N- HII: rnhB aminoacyl- processing 3-hydroxyacyl- hydroxy-2, 4- hydroxyphenol NifN: nifN synthetase: nadE ethanol HR45_RS07760 pyrimidine 5'- dehydrogenase: γ-D-isoglutaminyl- bifunctional [glutamate- adenine HR45_RS02745 subunit ClpA: clpA bifunctional biotin- bifunctional 2-succinyl-6- 4-phosphate homocitrate GDP sirohydrochlorin cis-aconitate phosphopentomutase: anaerobic adenosylcobinamide UDP-N- acetylmuramate:L- ribonuclease pyruvate tRNA peptidase: ACP cyclohexadiene- methylase/3- a NifEN protein 4-phosphoerythronate β-alanine nicotinate adenine dinucleotide NMN protoporphyrin IX HR45_RS07765 2-deoxy-D-ribose nucleotidase: yjjG guaB NAD- N-(β-D-asparaginyl) -ammonia ligase]- glycosylase: aspartate/ -[acetyl-CoA- riboflavin hydroxy-2, 4- 2-methoxy- synthase: ribB synthase: nifV (R)-pantoate uroporphyrinogen- ferrochelatase: pyruvate fermentation HR45_RS12820 adenosine ribonucleoside- kinase/ acetylmuramate:L- alanyl-gamma-D- HI: rnhA kinase: pyk ATP-dependent hydrolase: prc dehydratase 1-carboxylate demethylubiquinol 3- complex dehydrogenase: bifunctional HR45_RS07770 5-phosphate dependent -L-lysyl-D-alanine adenylyl-L-tyrosine mutY tyrosine/aromatic carboxylase] kinase/FAD cyclohexadiene- 6-(all-trans- III synthase: HR45_RS11805 to ethanol I deaminase: add [+ 3 isozymes] triphosphate adenosylcobinamide- alanyl-gamma-D- glutamyl- meso- Clp endopeptidase pth a peptide FabZ: fabZ synthase: menH O-methyltransferase 1-deoxy-L-glycero- containing HR45_RS14610 adenosylcobinamide- ferrochelatase: aconitate hydratase HR45_RS07775 2-deoxy-D-ribose XMP DNA ligase phosphorylase/ aminotransferase: synthetase/ synthetase: (1R,6R)-6-hydroxy- 1-carboxylate octaprenyl)phenol superpathway of adenosylcobalamin salvage from cobinamide I (2R)-homocitrate nicotinate-nucleotide HR45_RS07490 reductase- phosphate glutamyl- meso- diaminopimelate proteolytic aminoacyl- RS01910 FlgL bifunctional 3- UbiG: ubiG tetrulose 4-phosphate ARP an L-cluster (3R)-3-hydroxy-2-oxo- GDP pantoate--beta-alanine hemH siroheme 2/2-methylisocitrate 5-phosphate deoxyribose- LigA: ligA [glutamate-- a CDP-2,3,4- HR45_RS10860 biotin operon ribF 2-succinylcyclohexa- synthase: menH 2-octaprenyl-6- adenylyltransferase: pyruvate succinate guanosine activating guanylyltransferase: monofunctional diaminopimelate ligase: mpl an apurinic site DNA a nucleoside 5'- pyruvate subunit ClpP: clpP tRNA hydroxydecanoyl- 2-methoxy- 4 phosphooxybutanoate ribazoletransferase: ligase: HR45_RS10000 uroporphyrinogen-III dehydratase: acnB phosphate inosine pyrimidine 5'- ammonia-ligase] saturated- repressor: 2,4-diene-1- 2-succinyl-5- methoxyphenyl nadD protoheme protein: nrdG cobU biosynthetic ligase: mpl within DNA monophosphate dGTP 3-sulfopyruvate a peptide hydrolase: ACP dehydratase/ 6-(all-trans- cob(II)inamide 3-phosphoserine/ HR45_RS10440 deoxyribose- aldolase: nucleotidase: yjjG adenylyltransferase: adenine diacylglycerol HR45_RS18570 roseoflavin carboxylate enolpyruvyl- hydroxylase: ubiH 6,7-dimethyl-8- D-threo-isocitrate pyrimidine/purine [DNA] NMN peptidoglycan UDP-N-acetyl- arfB trans-2- octaprenyl)phenol phosphohydroxythreonine formate C- phosphate deoC pyrimidine/purine adenosyl- glnE adenine o-succinylbenzoate 6-hydroxy-3- 2-methoxy-6-all ribityllumazine Coα-[α-(2- (R)-pantothenate NaMN nicotinamide nucleoside [+ 3 isozymes] an active AMP transglycosylase: UDP-N-acetylmuramoyl- α-D-muramoyl- FlgA FlgK decenoyl-ACP 2-octaprenyl-6- cob(I)yrinic acid a NifEN protein transaminase: serC acetyltransferase: aldolase: nucleoside a flavodoxin cobinamide dinucleotide synthase: menC cyclohexene- trans-octaprenyl- synthase: ribE D-glyceraldehyde methyladenin-9-yl)]-Co nicotinamidase: NADP-dependent phosphorylase: 5'-deoxyadenosine met ribonucleoside mtgA L-alanyl-γ-D- L-alanyl-γ-D- biotinyl-5'- isomerase: fabA methoxyphenyl a,c-diamide complex pyruvate pflB deoC D-glyceraldehyde phosphorylase: semiquinone phosphate a purine 1,4-benzoquinol 3-phosphate 4-phosphooxy- β type I pantothenate HR45_RS08115 isocitrate HR45_RS08435 xanthosine Cys 1-carboxylic- adenosyltransferase: -adenosylcobamide acetaldehyde triphosphate ribonucleoside glutamyl-meso-2,6- glutamyl-meso-2,6- a [glutamine adenylate cys a tRNA hydroxylase: ubiH bifunctional containing L-threonine kinase: HR45_RS18575 dehydrogenase: 3-phosphate HR45_RS08435 a (2E)-enoylglutaryl- 2-succinylbenzoate 2-methoxy-6-all acid synthase: 6,7-dimethyl-8-(1-D-ribityl)lumazine cobO 5'-phosphate D-glyceraldehyde purine-nucleoside reductase 5'-diphosphate a peptidoglycan di-trans,octa-cis diaminopimeloyl- diaminopimelate synthetase]-O demethylmenaquinone an M-cluster nicotinate bifunctional purine-nucleoside 4 [acp] methyl ester trans-octaprenyl- HR45_RS09125 [corrinoid 1-deoxy-D- 4-hydroxythreonine- acetyl-CoA formate HR45_RS04095 acetaldehyde 3-phosphate phosphorylase: dimer (E. faecium -undecaprenyl D-alanine -(5'-adenylyl) methyltransferase/2- (R)-4'-phosphopantothenate phosphoribosyltransferase: acetaldehyde- phosphorylase: NrfA RS18410 o-succinylbenzoate- 1,4-benzoquinol 2-succinyl-5- riboflavin synthase: adenosyltranferase]- xylulose-5- 4-phosphate deoD pyrimidine/purine , tetrapeptide) diphosphate -L-tyrosine methoxy-6-polyprenyl- pncB bifunctional pyruvate fermentation 2-oxoglutarate bifunctional CoA/alcohol deoD -CoA ligase: menE HR45_RS03000 phosphate dehydrogenase α α nucleoside bifunctional enolpyruvoyl- cob(II)inamide Co -[ -(2- nicotinate acetaldehyde- to ethanol II acetaldehyde- purine ribonucleosides degradation 4-(2'- 1,4-benzoquinol riboflavin synthase: a NifDK protein synthase: dxs PdxA: pdxA Metabolic Regulator dehydrogenase: guanine phosphorylase: demethylmenaquinone 6-hydroxy-3- methyladenin-7-yl)]-Co 2503 α α carboxyphenyl)- methylase UbiE: ubiE containing 3-amino-1- Polyprenyl Biosynthesis Biosynthesis CoA/alcohol CoA/alcohol adhE hypoxanthine HR45_RS08435 adenine a mature peptidoglycan -Kdo-(2->4)- a DNA containing Nα,Nε-diacetyl-lysyl- a [glutamine a guanine 2445 phosphoenol a 1-acyl-2- queuosine at N-acetyl- - a glutaryl-[acp] methyltransferase/2- cyclohexene- HR45_RS18025 β-adenosylcobamide pyruvate Chemoautotrophic dehydrogenase: α-Kdo-(2->6)- an apurinic/ a protein with glutathione synthetase]-O H O D-muramoyl- digallate 4-oxobutyryl-CoA 6-methoxy-3- an M-cluster 1-deoxy-D-xylulose hydroxyacetone dehydrogenase: in 23S rRNA (meso-diaminopimelate a palmitoleoyl-[acp] D-alanyl-D-alanine in 23S rRNA 2 a tRNA precursor pyruvate arachidonoyl- asp glu position 34 ITP RS05490 methoxy-6-polyprenyl- 1-carboxylate 5-methylbenzimidazolyl adenosylcobamide Energy Metabolism purine-nucleoside a disulfide bond 4 GTP dADP methyl ester methyl-2-all- riboflavin [corrinoid ppGpp metabolism adhE ubiquinone- adhE acetyl-CoA adenosine containing) lipid IV (E. coli) apyrimidinic site -(5'-adenylyl) bifunctional sn-glycerol of a tRNA Asp L-alanine(1-) tannase/feruloyl 1,4-dihydroxy- 1,4-benzoquinol 2-succinyl-6- 5-phosphate 1-phosphate biosynthesis from adenosylcobinamide-GDP polyisoprenoid biosynthesis (E. coli) guanine phosphorylase: A aspartate/ beta-ketoacyl- trans-octaprenyl- adenosyltranferase]- geranyl dependent pyruvate -L-tyrosine 23S rRNA 3-phosphate CTP esterase family inosine/ 2-naphthoyl- methylase UbiE: ubiE hydroxy-2, 4- bifunctional dipyrromethane acetaldehyde hydrogen oxidation acetyl-CoA deaminase: guaD deoD bifunctional tRNA penicillin- tyrosine/aromatic xanthosine ACP synthase 1,4-benzoquinol cob(I)inamide pyridoxine 5'- diphosphate pppGpp dehydrogenase: poxB adenosine glutaredoxin (guanine(2069)-N(7) 1,6-anhydro-N- alpha/beta CoA synthase: 6-methoxy-3- cyclohexadiene- riboflavin kinase/ 5-methylbenzimidazole cofactor biosynthesis acetaldehyde I (aerobic) (adenosine(37)-C2) lytic murein LpxL/LpxP endonuclease binding GTPase ribonuclease aminotransferase: tRNA triphosphatase: I: fabB cob(I)yrinic acid phosphate IPP biosynthesis deaminase: 2: grxB )-methyltransferase acetylmuramyl- hydrolase: (2E,6E)-farnesyl HR45_RS17405 methyl-2-all- 1-carboxylate FAD synthetase: ribF menaquinol-7 biosynthesis adeninyl adenosylcobamide biosynthesis bifunctional -methyltransferase transglycosylase: family Kdo(2)- III: nth protein bifunctional [glutamate- HflX: hflX D: rnd pyruvate HR45_RS02745 glutamyl- yjjX RS10235 beta-ketoacyl- diphosphate [2Fe-2S] iron-sulfur synthase: menH a,c-diamide synthase: pdxJ nicotinate-nucleotide-- an apo-[hydroxymethylbilane H add xanthine HR45_RS14325 lipid IV(A) lauroyl/ RlmK/23S rRNA kinase: pyk L-alanine HR45_RS09230 1,4-dihydroxy-2- trans-octaprenyl- coenzyme A biosynthesis from adenosylcobinamide-GDP IPP bifunctional (p)ppGpp acetaldehyde- bifunctional 2 TrmG/ribosomal bifunctional DNA- 2: mrdA glutathione- -ammonia ligase]- [+ 3 isozymes] aspartate/ Q(34) ACP synthase cluster biosynthesis (1R,6R)-6-hydroxy- FMN adenosyltransferase: 1,4-dihydroxy- dimethylbenzimidazole synthase]-L-cysteine isopentenyl- synthetase/guanosine- Ni/Fe-hydrogenase, Aldehyde Degradation [+ 4 isozymes] palmitoleoyl dependent adenylyl-L-tyrosine (guanine(2445)-N(2) synthetase amidase tannase/feruloyl IDP octaprenyl naphthoyl-CoA 1,4-benzoquinol I (prokaryotic) (2E,6E)- CoA/alcohol acetaldehyde- RNA large subunit formamidopyrimidine D-alanyl-D-alanine tyrosine/aromatic II: fabF 2-succinylcyclohexa- 3-demethylubiquinol-8 cobO 2-naphthoate phosphoribosyltransferase: diphosphate 3',5'-bis(diphosphate) 3'- b-type cytochrome: UTP and CTP dephosphorylation I xanthosine adenosine inosine guanosine acyltransferase: disulfide-bond phosphorylase/ )-methyltransferase GluQRS: AmpD: ampD esterase family diphosphate 1,4-dihydroxy- farnesyl dehydrogenase: CoA/alcohol methyltransferase glycosylase/ + a nucleoside 5'- aminotransferase: 2,4-diene-1- bifunctional pyridoxine 5'-phosphate (R)-4'- cobT Delta- carboxypeptidase/ RlmL: rlmKL phosphate H a tRNA a CDP-1-acyl- synthase: ispB L-cysteine desulfurase adenine a [hydroxymethylbilane diphosphate pyrophosphohydrolase: adhE dehydrogenase: adhE HR45_RS03240 cybH methylglyoxal degradation I RlmN: trmG/rlmN a mature peptidoglycan a mature peptidoglycan lpxL DNA-(apurinic oxidoreductase: [glutamate-- an N 2 - GDP monophosphate pyruvate gluQRS alpha/beta a 3-oxopimeloyl- carboxylate bifunctional 2- riboflavin kinase/ adenosylcobinamide 2-naphthoate isomerase: idi bifunctional GTP D-alanyl-D-alanine- 2-arachidonoyl- HR45_RS10860 YbgF all-trans- phosphopantothenate synthase] ES intermediate HR45_RS04640 HR45_RS03255 cybH UTP γ strand (non- or apyrimidinic yghU ammonia-ligase] 2445 dATP N-acetyl-D- hydrolase: [acp] methyl ester polyprenyl-6- polyprenyltransferase: pyridoxamine bifunctional adenosylcobinamide- 5-methylbenzimidazole 2 synthase: ispA diphosphokinase/ urate with (L-alanyl- -D- endopeptidase: dacB methylguanine oxaloacetate octaprenyl 1,4-dihydroxy- cysteine o-succinylbenzoate FAD synthetase: ribF bifunctional nicotinate-nucleotide-- geranyl ethanol ethanol hydrogenase large pyrimidine/purine pyrimidine/purine pyrimidine/purine pyrimidine/purine reducing terminus) Kdo - site) lyase: mutM adenylyltransferase: glycerol ala muramate HR45_RS07630 3-demethylubiquinol-8 HR45_RS15225 5'-phosphate phosphopantothenoylcysteine GDP ribotide phosphate hydroxymethylbilane DMAPP [+ 2 isozymes] guanosine-3',5'-bis glutamyl-meso-2,6- 2 in 23S rRNA glutamyl- 3-oxoacyl- 2-naphthoate synthase: menC hydroxyphenol diphosphate CTP synthase: methylglyoxal a 2-methyladenine 2503 diphosphate desulfurase: FAD adenosylcobinamide demethylmenaquinol-7 oxidase: pdxH decarboxylase/ dimethylbenzimidazole synthase: hemC pyrophosphate 3'- subunit: HR45_RS13015 nucleoside nucleoside nucleoside nucleoside 5'-deoxyadenosine diaminopimeloyl-D- acyl-carrier protein (palmitoleoyl) a protein with glnE queuosine at gallate ACP methylase/3- lactoylglutathione in 23S rRNA met α ε HR45_RS10120 bifunctional 2- kinase/ phosphopantothenate-- phosphoribosyltransferase: (2E,6E)- pyrophosphohydrolase: spoT guanosine-5'-triphosphate,3'- pyruvate fermentation to acetoin III A(H2) HR45_RS06865 phosphorylase: phosphorylase: phosphorylase: phosphorylase: alanine) tetrapeptide -lipid IV N ,N -diacetyl- GSSG position 34 reductase 2-succinylbenzoate demethylubiquinol 3- adenosylcobinamide- a [hydroxymethylbilane lyase: gloA A a 3'-terminal a 5'-phospho- D-ala reduced L- 1,4-dihydroxy- [+ 2 isozymes] polyprenyl-6- adenosylcobinamide- bifunctional PLP cobT diphosphate phosphatase: UDP HR45_RS08435 HR45_RS08435 HR45_RS08435 HR45_RS08435 lysyl-D-alanine Asp TolB FabG: fabG O-methyltransferase (R)-4'- cysteine ligase CoaBC: coaBC GDP synthase] ES intermediate farnesyl (R)-S- unsaturated sugar [DNA] cysteine residues a [glutamine- of a tRNA 2-naphthoate hydroxyphenol phosphate demethylmenaquinone 3 HR45_RS05540 CTP pyrimidine an S-sulfanyl-[L- o-succinylbenzoate- UbiG: ubiG phosphopantothenoyl- ribazoletransferase: diphosphate pyruvate purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside lactoylglutathione synthetase]- 3-oxoacyl- polyprenyltransferase: methylase/3- guanylyltransferase: methyltransferase/2- adenine ribotide hydroxymethylbilane ATP ribonucleosides ADP cysteine desulfurase] -CoA ligase: menE L-cysteine HR45_RS10440 synthase: ispA phosphorylase: phosphorylase: phosphorylase: phosphorylase: L-tyrosine ACP HR45_RS15225 demethylubiquinol 3- cobU methoxy-6-polyprenyl- adenosylcobinamide- phosphate synthase: hemC biosynthesis degradation hydroxyacylglutathione 4-(2'- ubiquinol-8 bifunctional geranyl deoD deoD deoD deoD reductase O-methyltransferase 1,4-benzoquinol GDP α α ubiquinone- UMP cytidine hydrolase: gloB carboxyphenyl)- superpathway of tetrahydrofolate biosynthesis adenosyl-cobinamide phosphopantothenoylcysteine Co -[ -(5- a [hydroxymethylbilane diphosphate CDP RS11165 FabG: fabG UbiG: ubiG methylase UbiE: ubiE GTP ppGpp dependent pyruvate NADPH repair (prokaryotes) α cytidine methylbenzimidazolyl)]- synthase] ES intermediate ADP ubiquinone- pyrimidine 5'- -D-ribose- a ring-opened 7- 2069 α demethylmenaquinol-8 4-oxobutyryl-CoA phosphate decarboxylase/ 4 (R)-lactate an [HPr]- phosphoenol a peptidoglycan dimer (meso N-acetyl-muramoyl-(L- a peptidoglycan hydrogen a guanine (S)-1-pyrroline- GDP- -D- an [amino-group a (1->4)- a (3R)-3- adenosylcobinamide- β (2E,6E)- dehydrogenase: poxB deaminase: cdd a reduced an N-modified O-succinyl-L- an aromatic formate an S-sulfanyl-[cysteine 1,4-dihydroxy- phosphopantothenate-- Co -adenosylcobamide hydroxymethylbilane F0F1 ATP dependent pyruvate nucleotidase: 1-phosphate methylguanine L-histidine pyruvate -diaminopimelate containing) alanyl-γ-D-glutamyl-L- dimer (S. aureus) peroxide in 23S rRNA asp O-ureido-L- 5-carboxylate mannose carrier protein]- α-D-glucan hydroxypimeloyl- ubiquinol-8 bifunctional menaquinol-7 GDP farnesyl ubiquinone- NADPH uridine thioredoxin aminoacyl-[tRNA] homoserine ATP amino acid bifunctional desulfurase]-[disordered- 2-naphthoyl- GTP cysteine ligase CoaBC: coaBC 5'-phosphate synthase: hemC synthase: atpC dehydrogenase: poxB yjjG phosphopentomutase: in DNA lysyl-D-alanyl-D-alanine) bifunctional homoserine bifunctional C-terminal-γ- 1,4-alpha- [acp] methyl ester adenosylcobinamide 5,6-dimethylbenzimidazole ribazoletransferase: diphosphate dependent pyruvate aspartate/ 3-hydroxyacyl- demethylmenaquinone form scaffold CoA synthase: atpD atpG acetaldehyde CMP [+ 3 isozymes] HR45_RS12820 pyrimidine/purine Secondary Metabolite Degradation 23S rRNA adenylate/guanylate proline (L-glutamate 5- glucan kinase/ HR45_RS10440 a holo-[hydroxymethylbilane synthase: ispA dehydrogenase: poxB phosphoenolpyruvate- penicillin-binding penicillin- tyrosine/aromatic formate GDP-mannose RS13690 ACP methyltransferase/2- protein] complex (2E,6E)-farnesyl HR45_RS17405 GTP 4'-phosphopantetheine nucleoside- atpA atpH pyrimidine 5'- nucleoside thioredoxin- (guanine(2069)-N(7) cystathionine argininosuccinate cyclase domain- dehydrogenase/L- semialdehyde-2-N-acetyl- branching adenosylcobinamide- nicotinate-nucleotide-- synthase] bifunctional GTP uridine D-ribose 5- bifunctional DNA- -protein protein 2: mrdA penicillin-binding binding aminoacyl- aminotransferase: dehydrogenase- mannosyl dehydratase methoxy-6-polyprenyl- diphosphate cyclohydrolase Coα-[α-(adenin-9-yl)]- Coα-[α-(5- (2E,6E)-farnesyl diphosphate kinase: ndk atpF atpE atpB nucleotidase: phosphorylase: pyruvate D-galacturonate degradation I dependent )-methyltransferase gamma- synthase: containing protein: glutamate gamma- yl)-L-glutamategamma- protein 1,4-dihydroxy-2- phosphate dimethylbenzimidazole pantetheine- folate transformations III (E. coli) diphosphokinase/ bifunctional (p)ppGpp phosphate β-D-glucuronide formamidopyrimidine phosphotransferase: ptsP D-alanyl-D-alanine protein 2: mrdA protein tRNA HR45_RS02745 N subunit hydrolase: FabZ: fabZ 1,4-benzoquinol I FolE: folE Coβ-adenosylcobamide methylbenzimidazolyl)]- diphosphate HR45_RS17490 acetoin yjjG HR45_RS08435 thiol RlmK/23S rRNA synthase: metB HR45_RS17745 HR45_RS07360 semialdehyde glutamyl- GlgB: glgB octaprenyl naphthoyl-CoA guanylyltransferase: phosphoribosyltransferase: phosphate guanosine-3',5'-bis synthetase/guanosine- and D-glucuronate glycosylase/ carboxypeptidase/ D-alanyl-D-alanine 2: mrdA hydrolase: alpha: fdnG HR45_RS13400 a (1,6)-α-D- methylase UbiE: ubiE a [cysteine desulfurase]- 7,8- 5'-phosphate Coβ-adenosylcobamide ATP (R)-NADPHX pyrimidine deoxyribonucleotides uridine aldehydo-D- phosphoenolpyruvate- peroxidase: (guanine(2445)-N(2) dehydrogenase aspartate/ phosphate bifunctional 3- diphosphate cobU cobT adenylyltransferase: pyrophosphate 3'- 3',5'-bis(diphosphate) 3'- bifunctional [+ 3 isozymes] degradation DNA-(apurinic D-alanyl-D-alanine- carboxypeptidase/ D-alanyl-D-alanine pth class I adenylate an [amino-group glucosyl-(1,4) dihydroneopterin a tetrahydrofolate isoprenyl octaprenyl dephosphorylation phosphorylase: galacturonate β -protein bcp )-methyltransferase PutA: putA tyrosine/aromatic formate reductase: FlgA hydroxydecanoyl- menaquinol-8 S-sulfanyl-[disordered- synthase: ispB coaD pyrophosphohydrolase: spoT pyrophosphohydrolase: ADP-dependent a -D- or apyrimidinic endopeptidase: dacB D-alanyl-D-alanine- aminoacyl- cyclase: carrier protein]- -α-glucan 3'-triphosphate adenosylcobinamide- α transferase: diphosphate cytidine nucleoside triphosphate udp glucuronate phosphotransferase: ptsP carboxypeptidase/ RlmL: rlmKL succinate canavaninosuccinate aminotransferase: dehydrogenase- D-mannose argC form scaffold all-trans- -ribazole 5'-phosphate HR45_RS04640 NAD(P)H-hydrate glucuronoside site) lyase: mutM endopeptidase: dacB peroxiredoxin C: 7 L-homocysteine HR45_RS07500 γ ACP dehydratase/ GDP 3'-dephospho- HR45_RS11920 synthase: ispB GTP diphosphokinase: relA pyrophosphohydrolase: S-methyl-5'-thioadenosine isomerase: D-alanyl-D-alanine- tRNA an N - glu HR45_RS10860 N subunit GDP C-terminal- - protein] complex octaprenyl 1,4-dihydroxy- HR45_RS04130 2069 cyclic-AMP trans-2- CoA Coα-[α-(adenin-7-yl)]- dihydrofolate methionine synthase: metH bifunctional GTP dehydratase/ degradation IV uracil a peptidoglycan with endopeptidase: dacB hydrolase: methylguanine an aromatic (5-phospho- cysteine diphosphate 2-naphthoate mazG uxaC an [HPr protein]- alpha: fdnG β NAD(P)H-hydrate a [DNA]- 2,6-diamino-4- π 2-oxo-acid decenoyl-ACP desulfurase: adenosylcobinamide- superpathway of thiamine diphosphate biosynthesis I dephospho- Co -adenosylcobamide reductase: folM di-trans,octa-cis all-trans- diphosphokinase/ Macromolecule Modification dCTP dCMP D-glucopyranuronate a 5'-phospho- N -phospho- pyruvate D,D cross-links (meso- D-ala N-acetyl-muramoyl-(L- arfB in 23S rRNA L-glutamyl)- 7,8- epimerase: S-methyl-5'- nucleotide- hydroxy-5-(N-methyl) 4-oxo-2-pentenal γ RS14245 isomerase: fabA HR45_RS10120 GDP CoA kinase: -undecaprenyl octaprenyl guanosine-3',5'-bis D-tagaturonate [DNA] L-histidine diaminopimelate containing) alanyl- -D-glutamyl- D-ala a peptidoglycan an oxidized H O L-glutamate 1,4-dihydroxy- dihydroneopterin thioadenosine 2 an electron- NAD de novo biosynthesis coaE diphosphate diphosphate pyrophosphate 3'- HR45_RS10765 5'-methylthioadenosine/ 3'-phosphate formamidopyrimidine L-lysyl-D-alanine) with D,D cross- thioredoxin CO a (2E)-enoylpimeloyl- [+ 2 isozymes] 2-naphthoate 3'-phosphate ribazoletransferase: serine tRNA-uridine 2-thiolation dUTP diphosphatase: dut tagaturonate D-ala 2 I (from aspartate) an S-sulfanyl-[cysteine cys undecaprenyl- pyrophosphohydrolase: spoT (S)-NADPHX an N-modified an uncharged transfer quinol [acp] methyl ester polyprenyltransferase: HR45_RS10440 a 7,8-dihydrofolatehydroxymethyltransferase:a 5-methyltetrahydrofolate GDP and selenation (bacteria) 5-(methoxycarbonylmethoxy) nucleoside triphosphate adenosylhomocysteine reductase: link (S. aureus) desulfurase]-S- coenzyme A diphosphate aldehydo-D- amino acid tRNA HR45_RS15225 HR45_RS18010 glycine cleavage system uridine biosynthesis bifunctional pyrophosphohydrolase: nucleosidase: HR45_RS03740 asp sulfanyl-[disordered- cysteine protein R: HR45_RS02585 a (6S)-5-formyltetrahydrofolate phosphatase: HR45_RS07395 glucuronate RS12230 adenosylcobalamin Aromatic Compound Biosynthesis ADP-dependent mazG form scaffold D-erythro-7,8- desulfurase: [+ 3 isozymes] bifunctional HR45_RS18405 cys dUTP dUMP MTR D-altronate glucuronate L-aspartate 5'-phosphate HR45_RS10120 methylenetetrahydrofolate5-formyltetrahydrofolate di-trans,octa-cis SAM NAD(P)H-hydrate a 7,8-dihydro- a peptidoglycan an N-formyl-L- an N 3 -methyladenine a mature an N-terminal- an N-terminal- a peptide with an unstable protein] complex demethylmenaquinol-8 dihydroneopterin prephenate isomerase: a peptidoglycan β an ADP-sugar 34 oxidase: nadB dehydratase/ 8-oxoguanine dimer (E. faeciums) methionylaminoacyl- peptidoglycan D-glycero- -D- a PII protein L-methionyl-L- γ-L-glutamyl-(S)- gly L-methionyl-L- an N-terminal a cytidine lys 3',5'-ADP RecA filament- a pimeloyl-[acp] [+ 2 isozymes] dehydrogenase/ cyclo-ligase: -undecaprenyl chorismate biosynthesis I cysteine altronate in DNA (n) ATP chorismate 3-(4-hydroxyphenyl) uxaC manno-heptose ATP Ile2 methyl ester 2-iminosuccinate dihydroneopterin an [L-cysteine methylenetetrahydrofolate methenyltetrahydrofolateHR45_RS01835 phosphate desulfurase: NAD(P)H-hydrate dehydratase: in DNA tRNA (meso-DAP UTP threonyl-[protein] 2-aminobutanoate RNA seryl-[protein] L-alanine in tRNA 3'(2'),5'- DNA complexDNA bis(guanylyl molybdopterin) cofactor sulfurylation thymidylate synthase: thyA pyruvate biosynthesis 5-hydroxy-CTP 5-hydroxy-CMP 1-phosphate RS07120 aldolase: folB desulfurase]-S- reductase: metF cyclohydrolase FolD: folD D-erythrose HR45_RS10120 carboxy-S- epimerase: HR45_RS03745 D-fructuronate containing) bisphosphate repair pimeloyl-ACP quinolinate a [cysteine aminodeoxychorismate/ NADH repair (prokaryotes) 1,6-anhydro-N- penicillin-binding DNA-3- ADP sulfanyl-L-cysteine a [ThiS sulfur- a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate 4-phosphate adenosyl-L- HR45_RS10765 type I methionyl glutathione type I methionyl tRNA nucleotidase protein methyl ester synthase desulfurase]-(S- 6-(hydroxymethyl) anthranilate synthase adenosylcobalamin 3-deoxy-7- [+ 2 isozymes] 2-dehydro-3- bifunctional DNA- acetylmuramyl- protein 2: mrdA peptide methyladenine bifunctional compounds aminopeptidase adenosylcobalamin cysteine carrier protein] tyr an [L-cysteine methionine bifunctional D-glycero- aminopeptidase: synthase: polynucleotide aminopeptidase: lysidine(34) CysQ: cysQ RecO: esterase NadA: nadA sulfanyl) -[disordered- S-adenosyl-L-methionine salvage I -7,8-dihydropterin component II: cys bifunctional phosphoheptulonate NADH NADPH deoxy-D-gluconate formamidopyrimidine L-alanine D-alanyl-D-alanine deformylase: glycosylase I: lytic murein uridylyltransferase/ hydrolase N: pepN 2 salvage from cobalamin desulfurase: aspartate/ desulfurase]-S- synthase beta-D-manno- map gshB adenylyltransferase map BioH: bioH 2-amino-4-hydroxy-6- HR45_RS10685 methylenetetrahydrofolate 2-dehydro-3- glycosylase/ amidase carboxypeptidase/ HR45_RS17640 transglycosylase: uridylyl-removing NudE: nudE aminopeptidase synthetase 3'(2'),5'- a stabilizedrecO quinolinate form scaffold HR45_RS10120 synthase: tyrosine/aromatic sulfanyl-L-cysteine CmoA: cmoA HR45_RS17575 heptose-7-phosphate PcnB: HR45_RS09985 RS03190 hydroxymethyldihydropteridine [+ 2 isozymes] cysteine dehydrogenase/ Amino Acid Degradation deoxygluconokinase: DNA-(apurinic AmpD: ampD D-alanyl-D-alanine- peptide HR45_RS14325 protein GlnD: glnD N: pepN TilS: tilS bisphosphate RecA filament- protein] complex cob(I)alamin [+ 2 isozymes] HR45_RS07205 aminotransferase: DNA-3- kinase/D-glycero- a pimeloyl-[acp] SAH diphosphokinase: folK desulfurase: methenyltetrahydrofolate HR45_RS03750 or apyrimidinic endopeptidase: dacB deformylase: [+ 4 isozymes] an N-terminal L- an N-terminal an α-D-aldose nucleotidase DNA complex carboxylating 4-amino-4- a [ThiI sulfur- a carboxy- molybdopterin biosynthesis 3-deoxy-[+ 2 isozymes] HR45_RS10860 a 5- S-adenosyl-S- methyladenine beta-D-manno- ophthalmate D-glyceraldehyde HR45_RS10120 site) lyase: mutM met met 34 2-amino-4-hydroxy-6- deoxychorismate cyclohydrolase FolD: folD hydroxyuridine 34 carboxymethyl- L-threonine ditrans,octacis- a peptidoglycan def threonyl-[protein] L-seryl-[protein] 1-phosphate a lysidine CysQ: cysQ 8-amino-7- nicotinate- 5'-methylthioadenosine/ 3-phosphate carrier protein]-S- adenylated-[ThiS D-arabino- aspartate/ a [TusA sulfur- L-arginine degradation L-histidine degradation II L-proline degradation I glycosylase I: heptose 1-phosphate a uridylylated RNA AMP hydroxymethyldihydropteridine AIR tyr [+ 2 isozymes] in tRNA L-homocysteine degradation I L-leucine degradation I L-citrulline degradation KDGP undecaprenyldiphospho- pentapeptide a peptidoglycan tetramer a mature GlcNAc-1,6- ala a peptide in tRNA Ile2 nucleotide adenosylhomocysteine aminodeoxychorismate sulfanyl-L-cysteine sulfur-carrier protein] 10 heptulosonate (R)-NADHX HR45_RS17060 adenylyltransferase PII protein oxononanoate a [cysteine desulfurase]- cob(II)alamin 1-deoxy-D- an [L-cysteine an N -formyltetrahydrofolate tyrosine/aromatic carrier protein]-S- II (AST pathway) a [DNA]- N-acetyl-(N- peptidoglycan anhMurNAc- AMP RS09140 diphosphorylase: diphosphokinase: folK bis(guanylyl benzimidazolyl adenosylcobamide bifunctional a 5'-phospho- 7,8-dihydro- with a D,D cross-link D-ala (n) synthase: [scaffold protein- nucleosidase: lyase: pabC phosphomethylpyrimidine desulfurase]-S- ATP 7-phosphate aminotransferase: sulfanyl-L-cysteine 4-oxo-2-pentenal formate a L-methionylaminoacyl- γ HldE: hldE nadC (7,8-dihydropterin- 2-iminoacetate xylulose-5- molybdopterin) cofactor biosynthesis from adenosylcobinamide-GDP cys GTP tRNA 5- ADP-dependent thr pro nucleotide- [DNA] 8-oxoguanine acetylglucosaminyl)muramate (Enterococcus faecium) (meso-DAP L-Ala- -D-Glu- HR45_RS05085 (2Fe-2S)] complex cob(I)yrinic acid HR45_RS07395 synthase ThiC: thiC sulfanyl-L-cysteine 3-dehydroquinate 3-(4- HR45_RS02745 sulfurtransferase leu his L-citrulline bifunctional tRNA an apurinic site 6-yl)methyl 4-aminobenzoate synthase phosphate methoxyuridine(34) NAD(P)H-hydrate arg 3'-phosphate 3-methyladenine containing) DAP-D-Ala a,c-diamide formate cysteine synthase: aroB hydroxyphenyl) complex: tusD threonine branched-chain histidine bifunctional ornithine 4-hydroxy-2- β (8S)-8-amino-7- NaMN S-ribosyl-L- diphosphate ThiH: thiH synthase: dxs benzimidazole molybdopterin- cysteine GTP 3',8- /uridine 5-oxyacetic arginine N- within DNA ADP-D-glycero- - adenosyltransferase: HMP-P a thiocarboxylated- dehydrogenase desulfurase: pyruvate tusC dsrH dehydratase/ ammonia- amino acid ammonia- proline carbamoyltransferase: oxoglutarate oxononanoate homocysteine 1-deoxy-D-xylulose synthase desulfurase: cyclase acid(34) synthase succinyltransferase: D-manno-heptose nicotinate-nucleotide cobO 2-iminoacetate [ThiS sulfur- accessory HR45_RS10120 3-dehydroquinate a [TusD sulfur- NAD(P)H-hydrate lyase, aminotransferase: lyase: hutH dehydrogenase/L- HR45_RS17740 aldolase/2- RS07285 adenosylmethionine- a [co-chaperone]- dihydropteroate 5-phosphate nicotinate-nucleotide-- adenylyltransferase HR45_RS10120 MoaA: moaA CmoB: cmoB 2 astA carbamoyl adenylyltransferase: cob(II)alamin- bifunctional carrier protein] sulfurtransferase [+ 2 isozymes] carrier protein]-S- epimerase: biosynthetic: HR45_RS13795 N -succinyl- urocanate glutamate gamma- dehydro-3-deoxy- -8-amino-7- [scaffold protein- S-ribosylhomocysteine synthase: folP dimethylbenzimidazole MoeB: moeB [+ 2 isozymes] (8S)-3',8-cyclo-7,8- type II 3- HR45_RS10765 4-methyl-2- L-arginine phosphate GlcNAc-1,6- lipid II (meso a [ThiI sulfur- a [ribosomal nadD [corrinoid hydroxymethylpyrimidine FdhD: fdhD a [bis(guanylyl a carboxy-adenylated an [L-cysteine sulfanyl-L-cysteine ilvA semialdehyde phosphogluconate an N-terminal an L-phenylalanyl- a heme(III)-bound a [protein]- 2-hydroxy-4-oxobutane- 4-nitrophenyl a D-tryptophanyl- a CDP- a D-aspartyl- N-acetyl- an L-cysteinyl- oxononanoate (2Fe-2S)] complex lyase: luxS glutathione- S-adenosyl-L-methionine salvage II thiazole synthase: phosphoribosyltransferase: dihydroguanosine dehydroquinate a 5-(carboxymethoxy) (S)-NADHX (2Z)-2-aminobut- oxopentanoate urocanate a 5,10-gly a uridine 34 a CcmAB complex anhMurNAc-L-Ala- diaminopimelate carrier protein]- cys FAD 4-hydroxy-L-threonine L-allo-threonine protein L3]- adenosyltranferase] kinase/ molybdopterin) [small subunit of desulfurase]-S- N-succinylarginine dehydrogenase glutamine- aldolase: arginyl-[protein] Phe L-threonine 1,2,4-tricarboxylate palmitate [tRNA Trp ] diacylglycerol [tRNA asp ] [tRNA Pro ] nicotinate adenine 7,8- [bis-MGD cofactor cobT 5'-triphosphate 34 2-enoate hydratase: [tRNA ] CcmCDE complex L-citrulline transaminase: bioA glutaredoxin phosphomethylpyrimidine HR45_RS02600 cofactor chaperone]- dehydratase: aroQ uridine in tRNA PutA: putA hydrolyzing methylenetetrahydrofolate in tRNA γ-D-Glu-DAP-D-Ala containing) L-cysteine L-glutamine dinucleotide dihydropteroate chaperone]-bis-MGD benzimidazole molybdopterin synthase] sulfanyl-L-cysteine cyclic pyranopterin bifunctional dihydrolase: astB HR45_RS18555 (S)-1-pyrroline- HR45_RS11525 RS12900 (7R,8S)- redox reactions kinase: HR45_RS02615 S-sulfanyl-L-cysteine carbamoyl- AI-2 L-homocysteine bifunctional 2-[(2R,5Z)-2-carboxy- adenosylcobinamide- ribotide monophosphate 3-dehydroshikimate a [TusE sulfur ADP-dependent N 2 -succinyl- 5-carboxylate FAD:protein FMN putative 4- CDP- diaminononanoate ammonia- ammonia- a [chaperone-ATP]- glutathione SAH 4-imidazolone- phosphate bifunctional leucyl/ cytochrome c 1,6-anhydro-N- monofunctional low-specificity arylesterase: D-tyrosyl- low-specificity D-tyrosyl- acetylornithine Cys- cob(I)alamin- 4-methylthiazol-5(2H)- GDP phosphate 34 carrier protein]-S NAD(P)H-hydrate 3-methylbutanoyl- tRNA uridine-5- cysteine dependent dependent tetrahydrofolate HMP-PP formate synthase a uridine in tRNA L-ornithine 5-propanoate 4-hydroxy-2- phenylalanyl- transferase: hydroxy-4-methyl- HR45_RS05260 diacylglycerol dethiobiotin [co-chaperone]- [corrinoid adenosylhomocysteinase: ylidene]ethyl phosphate shikimate -sulfanylcysteine dehydratase/ CoA synthase: carboxymethylaminomethyl(34) biogenesis heme- acetylmuramyl- biosynthetic desulfurase L-threonine tRNA(Tyr) L-threonine tRNA(Tyr) deacetylase: tRNA(Pro) a [ribosomal NAD(+) NAD(+) 5-methyltetrahydropteroyltriglutamate- synthase/ bis(guanylyl molybdenum dehydrogenase MoaC: moaC a 5-(methoxycarbonylmethoxy) 2-iminobutanoate succinylornithine oxoglutarate tRNA--protein HR45_RS18845 2-oxoglutarate diphosphatase: [scaffold protein- HR45_RS14005 dehydrogenase: 34 imidazolonepropionase: carA carB synthesis enzyme MnmG: mnmG transporting L-alanine peptidoglycan aldolase: ltaE deacylase: dtd aldolase: ltaE deacylase: argE deacylase: protein L3]- synthase: bioD synthetase: synthetase: adenosyltranferase] - homocysteine S- dihydrofolate cofactor) biosynthesis adenosylcobinamide- a thiocarboxylated uridine in tRNA NAD(P)H-hydrate isovaleryl-CoA transaminase: aldolase/2- NifS: nifS FAD:protein FMN aldolase: HR45_RS14845 RS05060 (2Fe-2S)] complex a reduced accessory cyclic pyranopterin folate polyglutamylation aroE HR45_RS18540 transferase: ATPase amidase transglycosylase: dtd ybaK 5 cob(I)yrinic acid methyltransferase: metE synthase: folC L-homocysteine thiamine GDP [small subunit of tRNA 2- epimerase: dehydrogenase: L-glutamate-5- tRNA uridine-5- [+ 2 isozymes] HR45_RS11135 N -methyl- dethiobiotin nadE nadE glutaredoxin MoO - sulfurtransferase phosphate HR45_RS10670 carbamate dehydro-3-deoxy- aat CcmA: ccmA AmpD: ampD mtgA transferase: 4-nitrophenol palmitate a,c-diamide phosphate 2 ribazoletransferase: molybdopterin synthase] thiouridine(34) HR45_RS10765 2 carboxymethylaminomethyl(34) L-glutamine [+ 3 isozymes] 7,8-dihydrofolate molybdopterin FdhD: fdhD shikimate HR45_RS15245 N -succinyl- N-formimino- semialdehyde phosphogluconate HR45_RS17010 glycolaldehyde CMP a 1,2-diacyl- + 5-methyltetrahydropteroyltriglutamate- molybdopterin a tetrahydrofolate Trp acetaldehyde acetate NAD adenosyltransferase: glutaredoxin synthase: HR45_RS10440 synthase 3-methylcrotonyl- L-glutamate 5- aldolase: eda synthesis GTPase MnmE: mnmE a [ThiI sulfur- gly D-tryptophan a tRNA gly sn-glycerol L-citrulline biotin monoglutamate cofactor L-glutamate bifunctional asp Pro cobO met 2: grxB - homocysteine S- HR45_RS02615 molybdopterin shikimate MnmA: mnmA NADH 2-oxobutanoate L-phenylalanyl-L- N-acetyl-β-D- L-alanyl-γ-D- lipid II (meso di-trans,octa-cis ala carrier protein]- oxaloacetate pyruvate tRNA D-aspartate cys a tRNA synthase a [chaperone- α α CoA semialdehyde a tRNA Phe 3-phosphate adenosylcob(III) methyltransferase: metE sulfo-bis(guanylyl Co -[ - synthase: formimidoylglutamate proline arginyl-[protein] a heme(III)-bound glucosamine-1,6- glutamyl-meso-2,6- diaminopimelate -undecaprenyl a [protein]-FMN- RS19085 an [2Fe-2S] glutathione- molybdenum cofactor formate-- bifunctional serine kinase succinylglutamate- 34 a CcmABCD complex S-sulfanyl- BioB: bioB glutathione ADP]-[disordered- 34 methylcrotonoyl- dehydrogenase/L- D-glyceraldehyde a 5-carboxymethylaminomethyluridine CcmE protein cluster protein alamin-[corrinoid methionine [+ 3 isozymes] molybdopterin) cofactor (benzimidazolyl)]-Co hydroxymethylpyrimidine moaD moaE AroK: aroK a 2-thiouridine Rubisco shunt 2-ketobutyrate deiminase: CO pyruvate a 7,8-dihydrofolate anhydro-N-acetyl- diaminopimeloyl- containing) diphosphate L-cysteine AMP L-threonine biosynthesis form scaffold dependent thiamine phosphate guanylyltransferase: β tetrahydrofolate tetrahydrofolate hydroxymethyltransferase: CoA carboxylase: semialdehyde glutamate gamma- 2 3-phosphate in tRNA 9-mercaptodethiobiotin adenosyltranferase] adenosyltransferase: -adenosylcobamide salvage in tRNA formate- HR45_RS18525 β-D-muramate D-alanine protein] complex disulfide-bond met mobA ligase: synthase/ HR45_RS18010 shikimate 3- HR45_RS15250 dehydrogenase: semialdehyde cob(I)yrinic acid HR45_RS10070 a 7,8-dihydrofolate glutathione- 5'-phosphate tRNA uridine-5- lyase: pflB N-formyl- oxidoreductase: thiamine- 4-amino-2-methyl-5- molybdopterin HR45_RS14145 dihydrofolate phosphate F6P 3-methylglutaconyl- astD dehydrogenase biotin cys glu a,c-diamide NAD peroxide carboxymethylaminomethyl(34) L-glutamate RS13780 yghU dihydrofolate methionine phosphate bis(molybdenum pyrimidinemethanol synthase: folC a 5,10- propanoyl-CoA N 2 - an N-terminal- an N-terminal- synthase adenosyltransferase: SAM phosphorylation and tetrahydrofolate salvage from bifunctional 3-phosphoshikimate 1- synthesis enzyme MnmG: mnmG CoA PutA: putA a purine base an N-terminal L-alanyl-γ-D-glutamyl-L- sn-glycero-3- D-glycero-D- a peptide with α a protein with redox reactions cofactor) 10 methylenetetrahydrofolate an L-phenylalanyl- H O 5'-deoxyadenosine a ribonucleoside NMN a D-tyrosyl- (S)-malate Ala -amylose reductase: folM adenosyltransferase: kinase: thiL an N - succinylglutamate diphosphate 2 manno-heptose a type IV prepilin L-methionyl-L- L-methionyl-L- an N-terminal a glycyl-[tRNA ] BioB: bioB cytidylyl molybdenum an [Fe-S cluster cobO transhydrogenation 5,10-methenyltetrahydrofolate α α hydroxymethylpyrimidine carboxyvinyltransferase: transketolase: tkt N-formylglutamate glycine cleavage lesion in DNA L-lysyl-[protein] Phe lysyl-D-alanyl-D-alanine phospho-N- formate Tyr glutamate-- reduced L- HR45_RS10070 GSSG molybdenum cofactor Co -[ - formyltetrahydrofolate bifunctional tRNA uridine-5- glu [tRNA ] triphosphate bifunctional alanyl-[protein] valyl-[protein] [tRNA ] malate 1,4-alpha- cofactor sulfurylation biosynthesis kinase/ a tetrahydrofolate aroA succinylglutamate deformylase: hutG (arachidonoyl) 7-phosphatebifunctional D-glycero- L-methionine biotin thioredoxin cysteine ligase: adenosylcobalamin cysteine residues a tetrahydrofolate NAD + thiamine diphosphate guanylyltransferase: a 5,10- (benzimidazolyl)]-Co tetrahydrofolate 5-enolpyruvoyl- carboxymethylaminomethyl(34) D-erythrose a [glycine- metallophosphatase/ dehydrogenase glucan chaperone]-ATP β phosphomethylpyrimidine bifunctional desuccinylase: astE ethanolamine beta-D-manno- pathway HR45_RS06745 cytidylyl molybdenum SAM NAD(+) mobA methenyltetrahydrofolate -adenosylcobamide synthase/ shikimate 3- synthesis GTPase MnmE: mnmE 4-phosphate cleavage complex bifunctional DNA- penicillin-binding 5'-methylthioadenosine/ 5'-nucleotidase: (quinone): mqo branching RS09370 bifunctional kinase: HR45_RS02615 tetrahydrofolate propanoyl HMG-CoA glu leucyl/ RdgB/HAM1 family non- heptose-7-phosphate anaerobic prepilin type I methionyl type I methionyl type I methionyl D-tyrosyl- D-tyrosyl- bis(guanylyl 6 formamidopyrimidine protein 2: mrdA adenosylhomocysteine protein an oxidized cofactor (trioxo) thiamine diphosphate thiamine kinase: nadK glutathione- methylenetetrahydrofolate HMP-P synthase/ dihydrofolate phosphate a 5-carboxymethylaminomethyl- phosphate glu H protein] N -[(R glycine cleavage phenylalanyl- canonical purine NTP ribonucleoside- peptidase: HR45_RS06285 aminopeptidase: aminopeptidase: aminopeptidase: tRNA(Tyr) malate tRNA(Tyr) 34 glycerophosphodiester nucleosidase: kinase/D-glycero- γ + molybdopterin) synthase: folC chorismate 2-thiouridine in tRNA hydroxymethylglutaryl- )-lipoyl]-L-lysine system protein R: glycosylase/ D-alanyl-D-alanine GlgB: glgB thioredoxin -L-glutamyl- biosynthesis diphosphate NADP disulfide dehydrogenase/ dihydrofolate transaldolase: tal tRNA--protein pyrophosphatase: rdgB triphosphate HR45_RS17095 β [+ 2 isozymes] map map map deacylase: dehydrogenase deacylase: lipoate biosynthesis cofactor acetate kinase: DNA-(apurinic phosphodiesterase: HR45_RS07395 beta-D-manno- 1-( -D L-cysteine an [MCD cofactor II (Bacillus) salvage I reductase: methenyltetrahydrofolate bifunctional synthase: folC a 5,10- synthase: FAD-dependent 5- CoA lyase: glycine cleavage HR45_RS02585 transferase: inorganic carboxypeptidase/ reductase: nrdD dtd (quinone): mqo dtd amylopectin demethylmenaquinol- and incorporation I demethylmenaquinol- Re/Si-specific bis(guanylyl tungstenpterin) HR45_RS05305 or apyrimidinic HR45_RS18165 heptose 1-phosphate ribofuranosyl) glutathione chaperone]-MCD gorA cyclohydrolase FolD: folD hydroxymethylpyrimidine 10 methylenetetrahydrofolate aroC carboxymethylaminomethyl- D-glyceraldehyde D-sedoheptulose HR45_RS15265 system protein R: [+ 3 isozymes] aat diphosphatase: ppa D-alanyl-D-alanine- 6 biosynthesis I 9 biosynthesis 10 an N - protein S-nitrosylation [+ 2 isozymes] adenylyltransferase nicotinamide oxaloacetate synthase: HMP-PP thiamine menaquinol-6 biosynthesis NAD(P)(+) an N - cofactor biosynthesis kinase/ 2-thiouridine(34) 3-phosphate 7-phosphate HR45_RS02585 site) lyase: mutM endopeptidase: dacB a cleaved type an N-terminal L- an N-terminal thioredoxin- cysteine formyltetrahydrofolate chorismate and denitrosylation propanoate acetoacetate L-methionine degradation 5-deoxy-D-ribose β HldE: hldE a 2'- a peptide met met met a peptide all-trans- an octanoyl-[acp] all-trans- transhydrogenase formyltetrahydrofolate phosphomethylpyrimidine D-glycero- -D- IV prepilin alanyl-[protein] L-valyl-[protein] disulfide gshB desulfurase: oxidoreductase MnmC: mnmC I (to L-homocysteine) [+ 5 isozymes] L-phenylalanyl- adenine deoxyribonucleoside Tyr Ala hexaprenyl 1,4-dihydroxy- nonaprenyl 1,4-dihydroxy- a [protein]- a [glycine- Phe manno-heptose D-tyrosine a tRNA a tRNA gly lipoyl(octanoyl) subunit beta: pntB phosphoribosylglycinamide kinase: HR45_RS02615 a [DNA]- a tRNA H + γ sn-glycerol reductase: HR45_RS10120 2-naphthoate thiamine thiamine 2-naphthoate demethylmenaquinol-6 glutathione bis(tungstenpterin) GTP a 5-aminomethyl-2- transketolase: tkt a [glycine-cleavage a 5'-phospho- a modified L-lysyl-[protein] phosphate L-alanyl- -D-glutamyl- anandamide 5'-triphosphate glutathione diphosphate transferase diphosphate L-cysteine cleavage complex 6 nucleotide- 4-oxo-2-pentenal 1,7-bisphosphate trxB menaquinol-9 biosynthesis formyltransferase: purN thiouridine 34 in tRNA complex H protein] N - [DNA] nucleobase L-lysyl-D-alanine D-ala 3-phosphate [+ 2 isozymes] phosphate phosphate bifunctional NADPH cofactor HMP-PP met H protein] N 6 - a [cytidylyl molybdenum a [lipoyl-carrier protein]LipB: lipB D-ribose 5- D-xylulose aminomethyldihydrolipoyl- 3'-phosphate 1,4-dihydroxy- thiamine- thiamine- 1,4-dihydroxy- demethylmenaquinone a tetrahydrofolate FAD-dependent 5- methionine dihydrolipoyl- cofactor chaperone]- 2-naphthoate N 6 -octanoyl-L-lysine 2-naphthoate methyltransferase/2- demethylmenaquinol-9 molybdenum cofactor carboxymethylaminomethyl- phosphate 5-phosphate L-threonine degradation IV L-threonine adenosyltransferase: L-lysine phosphate phosphate a [protein] 3- L-lysine a reduced cytidylyl molybdenum polyprenyltransferase: lipoyl polyprenyltransferase: methoxy-6-polyprenyl- bifunctional guanylyltransferase: 2-thiouridine(34) degradation II HR45_RS10070 a [ribosomal a nascent peptidoglycan a reduced a precursor of an N-terminal- an XLLG adenosine an N-terminal- β a (1->4)- kinase: thiL kinase: thiL nitrosothio- a sulfurated ubiquinone-6 2-methylbutanoate a D-aminoacyl- GDP-β-L-fucose ADP-D-ribose N- -aspartyl- (R)-lactate carbonic acid thioredoxin cofactor (sulfo-dioxo) HR45_RS15225 synthase: lipA HR45_RS15225 1,4-benzoquinol demethylmenaquinone mobA oxidoreductase MnmC: mnmC ribose-5- ribulose- SAM protein S12] (meso-DAP containing) electron-transfer large subunit of L-methionyl-L- xylogulcan 2',3'-cyclic L-threo-3-phenylserine L-methionyl- α-D-glucan thiamine thiamine L-alanine thr [sulfur carrier] ATP [tRNA] L-arginine methylase UbiE: ubiE methyltransferase/2- phosphate phosphate 3- thr L-aspartate 89 flavoprotein a tRNA precursor hydrogenase 3 cysteinyl-[protein] monophosphate glycyl-[protein] D-2-hydroxyacid 1,4-alpha- diphosphate diphosphate a [lipoyl-carrier tRNA 2- glycine cleavage CTP bifunctional 2',3'- 6 menaquinol-6 methoxy-6-polyprenyl- bis(guanylyl isomerase epimerase: L-threonine 3- dehydrogenase: glucan demethylmenaquinol-6 protein]-N -[(R)- demethylmenaquinol-9 thiouridine(34) L-arginine degradation IV system protein R: lytic murein acetate- cyclic-nucleotide 2'- ADP-ribose isoaspartyl carbonate 1,4-benzoquinol tungstenpterin) cofactor RpiA: rpiA rpe dehydrogenase: electron transfer HR45_RS12575 branching dihydrolipoyl]-L-lysine synthase low-specificity (arginine decarboxylase/ HR45_RS02585 30S ribosomal transglycosylase: -CoA hydrogenase D-tyrosyl- type I methionyl phosphodiesterase/ low-specificity type I methionyl diphosphatase: peptidase/L- dehydratase: methylase UbiE: ubiE tdh flavoprotein- multifunctional D-2-hydroxyacid protein RS08240 MnmA: mnmA L-threonine agmatine deiminase pathway) [+ 3 isozymes] protein S12 HR45_RS14325 ligase: acs maturation tRNA(Tyr) aminopeptidase: 3'-nucleotidase: L-threonine aminopeptidase: nudF asparaginase: can RS07800 menaquinol-9 a [protein]- L-threonine ubiquinone CCA addition/ dehydrogenase: GlgB: glgB a 5-methylaminomethyl- S-nitrosoglutathione aldolase: ltaE SAH methylthiotransferase [+ 4 isozymes] peptidase deacylase: map HR45_RS14475 aldolase: ltaE map HR45_RS11320 L-cysteine dehydrogenase: arg oxidoreductase: repair protein: HR45_RS18175 a glycogen 2-thiouridine 34 in tRNA RimO: rimO (2S)-2- HycI: hycI dtd an XLFG 3'-AMP D-ribofuranose S-(hydroxymethyl) yiaY L-serine degradation HR45_RS09025 HR45_RS18415 Fatty Acid and Lipid Biosynthesis L-2-amino-3- adenosylhomocysteinase: biosynthetic arginine a mature peptidoglycan a nascent peptidoglycan methylbutanoyl- diphosphate an N-terminal L- GDP xylogulcan an N-terminal 5-phosphate pyruvate CO H O superpathway of pyrimidine Nucleoside and Nucleotide Biosynthesis tRNA 2- glutathione acetaldehyde gly AMP benzaldehyde AMP 2 2 Amine and Polyamine Biosynthesis superpathway of guanosine superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) inosine-5'-phosphate biosynthesis I superpathway of pyrimidine deoxyribonucleoside salvage selenouridine(34) D-ribulose oxobutanoate HR45_RS14005 decarboxylase: speA a [ribosomal with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) CoA a C terminal met cysteinyl-[protein] gly met glycyl-[protein] ribonucleotides de novo biosynthesis dehydrogenase/ L-aspartate an unsulfurated an oxidized a tRNA a large subunit an uncharged arg asp palmitate biosynthesis (type II fatty acid synthase) nucleotides de novo biosynthesis II synthase 5-phosphate bifunctional agmatine 5'-deoxyadenosine met protein S12]-3- meso-2,6-diaminopimeloyl- with GlcNAc terminus H + ubiquinol-6 32 amino- a D-amino acid FtsL oleate biosynthesis biotin-carboxyl carrier 2'-deoxycytidine class III alcohol glycine C- degradation I ser [sulfur carrier] electron-transfer containing a of hydrogenase 3 tRNA RS13210 (5Z)-dodecenoate phosphatidylglycerol spermidine biosynthesis III CTP MnmH: mnmH acetaldehyde- L-homocysteine methylsulfanyl- D-alanine) tetrapeptide acid peptide IV (anaerobic) protein assembly glutathionylspermidine gln AIR dehydrogenase: phosphoribulokinase: acetyltransferase: agmatine L-serine flavoprotein 3' CCA end biosynthesis I biosynthesis II (non-plastidic) hydrogencarbonate a 5-methylaminomethyl- CoA/alcohol L-aspartate 89 a [biotin biosynthesis IMP cytidine superpathway of guanine and guanosine salvage HR45_RS03475 HR45_RS10590 HR45_RS16810 deiminase: aguA asp ammonia-lyase: an acetoacetyl-[acp] a (3R)-3- 5-(carboxyamino) 2-(S-geranyl) dehydrogenase: a (3R)-3- carboxyl-carrier deaminase: 2-aminoprop-HR45_RS18500 hydroxydecanoyl- DHAP arg imidazole ribonucleotide thiouridine 34 in tRNA S-(hydroxysulfenamide) D-ribulose-1,5- adhE aspartate/ hydroxydodecanoyl-[acp] glutathione spermidine gly N-carbamoylputrescine 34 a [ThiI sulfur- N-acetyl-β-D- guanosine a (1->4)- 3-oxoacyl-ACP protein]-L-lysine glutamine- IMP CDP cdd tyrosine/aromatic 2-enoate a 5,10- a 2-thiouridine a [protein] N-terminal- + + + bifunctional 3- [acp] bifunctional 3- NAD(P)H- SAM synthase: purK dCMP tRNA 2- glutathione bisphosphate a 5-L-glutamyl- a uracil in tRNA α-D- ammonium NAD H O a [protein]-L-histidine NADP FMNH FMN NADH H α spermidine biosynthesis I hydrolyzing dehydrogenase: guanosine an amino acid carrier protein]- DL-allothreonine glu a (6S)-5- glucosaminyl-(1 2 2',3'-cyclic 2 glu ala Ap4A -D-glucan RS05000 reductase hydroxydecanoyl- dependent bifunctional biotin- biosynthetic selenouridine(34) ribulose-1,5- acetyl-CoA L-glutamine aminotransferase: methylenetetrahydrofolate in tRNA [peptide] formyl-L-methionine ATP GTP HtpX hydroxydecanoyl- putrescine biosynthesis II carbamoyl- guaB ribonucleoside- ribonucleoside- (d)CMP N-carbamoylputrescine S-sulfanyl- formyltetrahydrofolate -> 4)-N-acetyl- glucopyranose monophosphate histidine kinase: symmetrical 1,4-alpha- FabG: fabG ACP dehydratase/ glycerol-3- -[acetyl-CoA- adenosylmethionine arginine bifunctional N5-CAIR 2'-deoxyuridine synthase bisphosphate degradation I HR45_RS02745 bifunctional 2',3'- ACP dehydratase/ phosphate diphosphate diphosphate kinase: amidase: aguB L-cysteine β-D-muramate 1-phosphate HR45_RS04520 bis(5'-nucleosyl)- anaerobic glucan 3-oxoacyl-ACP trans-2- phosphate carboxylase] decarboxylase: decarboxylase: glutathionylspermidine MnmH: mnmH carboxylase L-glutamine aspartate/ tRNA uridine-5- peptide nitrite cyclic-nucleotide 2'- NAD(P) NAD(P) trans-2- SAM synthase: reductase: reductase: cmk serine nitrate/nitrite glutamate-- tetraphosphatase: ribonucleoside- branching reductase decenoyl-ACP dehydrogenase: synthetase/ HR45_RS03530 speA amidase/synthase: gss XMP formate 5-(carboxyamino)imidazole thymidine kinase: pyrimidine/purine a 5-methylaminomethyl- hydroxylamine small subunit: degradation II tyrosine/aromatic 2-iminopropanoate carboxymethylaminomethyl(34) gamma- bifunctional deformylase: reductase: phosphodiesterase/ H-flavin H-flavin decenoyl-ACP arg carA carB nrdA nrdB nrdA nrdB gln L-glutamate putrescine tRNA 4- hydroxymethyltransferase: glucose-1-phosphate two-component cysteine ligase: HR45_RS12525 triphosphate protein FabG: fabG isomerase: fabA gpsA biotin operon UDP ribonucleotide mutase: purE HR45_RS15445 dCDP nucleoside 2-(Se-phospho) HR45_RS18910 L-asparagine aminotransferase: synthesis enzyme MnmG: mnmG glutamyltransferase: ggt tetrahydrofolate HR45_RS17640 beta-N- nirD nirB 3'-nucleotidase: reductase: reductase: isomerase: fabA dAdoMet agmatine adenosylmethionine imidazole degradation I thiouridine(8) adenylyltransferase: system sensor reductase: nrdD GlgB: glgB H + PntB H + sn-glycerol repressor: biosynthetic arginine glutamine- dCDP thymidine phosphorylase: selenouridine 34 in tRNA degradation I gamma- HR45_RS18010 synthase/ acetylhexosaminidase: HR45_RS14475 fre fre HR45_RS06745 FtsA a (3R)-3- 3-hydroxyacyl- 3-hydroxyacyl- decarboxylase: glutathionylspermidine anaerobic ribonucleoside- ribonucleoside- asp nucleoside- inosine/ 3-phospho- gln glycerol HR45_RS10860 tRNA uridine-5- synthase peptide glgC histidine kinase ADP dGTP starch 3-phosphate HR45_RS18570 decarboxylase: speA carbamoyl hydrolyzing GMP CAIR dUMP HR45_RS08435 tRNA 2- oxaloacetate glutamyltransferase: ggt dihydrofolate nagZ 3'-GMP hydroxybutanoyl-[acp] ACP dehydratase ACP HR45_RS03530 asp ribonucleoside- diphosphate diphosphate diphosphate guanosine kinase: D-glycerate glutamate phosphate glu carboxymethylaminomethyl(34) ThiI: thiI deformylase: def NarQ: narQ glycerol-3- a [biotin carboxyl- agmatine phosphate synthase: guaA nucleoside- selenouridine(34) asn synthase: folC nitrite γ FabZ: fabZ dehydratase polyamine triphosphate reductase: reductase: thymidylate thymidine kinase: kinase: ndk purine-nucleoside HR45_RS11625 synthase large synthase: NAD-glutamate synthesis GTPase MnmE: mnmE acetaldehyde a [protein]-N- -L-glutamyl- bifunctional 3- carrier protein]-N putrescine dAdoMet hypoxanthine synthase ammonium 2,3-bisphosphoglycerate- pyruvate an α-(5-L- a [ThiI sulfur- gly N-acetyl-D- α FMN NADPH H + FMNH NAD + a (2E)-dodec-2-enoyl-[acp] phosphate 1-O- aminopropyltransferase: diphosphate phosphoribosylaminoimidazolesuccinocarboxamide phosphorylase: subunit: gltB L-alanine a 4-thiouracil ADP- -D-glucose 2 D-alanine + F0F1 ATP + FabZ: fabZ 6 agmatine reductase: nrdD nrdA nrdB nrdA nrdB synthase: HR45_RS15445 asparaginase: hisH hisF dehydrogenase: GlcNAc phospho-L-histidine H H hydroxydecanoyl- acyltransferase -biotinyl-L-lysine GMP kinase: ndk UTP dCTP phosphoribosyltransferase: MnmH: mnmH independent degradation IV glutamyl)- carrier protein]- an N-terminal L- muramate synthase a (2E)-dec- speE deiminase: aguA aspartate synthase: HR45_RS14015 thyA deoD glu ansA HR45_RS03890 a peptide in tRNA a (6S)-5- formate ACP dehydratase/ PlsY: plsY dUDP HR45_RS09925 a 5-methylaminomethyl- phosphoglycerate [+ 5 isozymes] a 5-aminomethyl-2- amino acid L-cysteine methionyl-[protein] bifunctional 3- 2-enoyl-[acp] polyamine carbamoyltransferase: 34 2-oxoglutarate a 7,8-dihydrofolate formyltetrahydrofolate RS04325 trans-2- spermidine synthase: anaerobic 2-selenouridine mutase: asp glu thiouridine 34 in tRNA hydroxydecanoyl- glycerol-3- aminopropyltransferase: N-carbamoylputrescine HR45_RS07460 guanylate dCTP hypoxanthine ala decenoyl-ACP bifunctional 3- HR45_RS10390 ribonucleoside- nucleoside- SAICAR in tRNA HR45_RS08670 ACP dehydratase/ hydroxydecanoyl- phosphate 1-O- a [biotin carboxyl- HR45_RS01325 [+ 2 isozymes] kinase: gmk guanine phosphoribosyltransferase: hpt tRNA processing isomerase: fabA dCTP triphosphate diphosphate 2-phospho- alanine RS12975 trans-2- acyltransferase carrier-protein N-carbamoylputrescine GMP a [2-oxoglutarate- a methylated a PepB 2251 (3R,5S)-3- ACP dehydratase/ N-carbamoyl- superpathway of adenosine adenylosuccinate dTMP dehydrogenase: ald 37 + guanosine 4-nitrophenyl RNase II poly-A 6 reductase: nrdD kinase: ndk D-glycerate a sulfurated a lipid II a peptidoglycan an L-arginyl- an adenosine adenosylcobinamide FMN NAD(P)H H β-citryl-L- 3-hydroxyacyl- decenoyl-ACP PlsB: plsB dimer]-N - N 1 -(3-aminopropyl) amidase: aguB deaminase: dcd adenine and adenosine salvage III SAM dehydrogenase 2-oxoglutarate nucleobase a protein DMAPP aminopeptidase γ-L-glutamyl- gly hydroxy-1- a protein trans-2- L-aspartate nucleotides de novo biosynthesis II lyase: purB a polycistronic pyruvate [tRNA Arg ] dGTP in 23S rRNA butanoate glutamine substrate mRNA ATP ACP dehydratase isomerase: fabA a 1-acyl-sn biotinyl-L-lysine spermidine GDP dTMP kinase: [sulfur carrier] 6 within DNA in tRNA bifunctional 23S rRNA D-alanine decenoyl-ACP agmatine tRNA precursor phosphopyruvate E2 protein] N - substrate pyrroline-5- HslU--HslV HflD FabZ: fabZ -glycerol 3- acetyl-CoA putrescine dihydroorotase: dUTP HR45_RS03990 adenosylcobinamide (guanosine(2251) anaerobic isomerase: fabA AICAR hydratase: eno octanoyl-L-lysine monofunctional NAD(P) carboxylatepyrroline-5- peptidase a (3Z)-dodec-3-enoyl-[acp] phosphate carboxylase HR45_RS03645 IMP Fatty Acid and Lipid Degradation alpha- kinase/ -2'-O)- arylesterase: ribonuclease ribonucleoside- dUTP asp adenine dTDP phosphoenol biosynthetic tRNA (adenosine(37)-N6) H-flavin glutathione carboxylate ATPase: a (2E)-but-2-enoyl-[acp] a (3Z)-dec- 1-acyl-sn-glycerol- biotin carboxylase nucleoside- ribonucleoside- ribonucleoside- bifunctional adenine and adenosine salvage I ribonuclease lipoyl ketoglutarate- arginyltransferase: adenosylcobinamide- aminopeptidase methyltransferase HR45_RS05260 N-formylglutamate R: rnr triphosphate diphosphatase: pyrimidine/purine nucleoside- pyruvate peptidoglycan dGTPase: -dimethylallyltransferase reductase: fre synthase: reductase: hslU hslV RS18145 beta-ketoacyl- 3-enoyl-[acp] 3-phosphate subunit: (S)-dihydroorotate diphosphate diphosphate diphosphate phosphoribosylaminoimidazolecarboxamide E: rne ribonuclease oleate β-oxidation synthase: dependent HR45_RS04070 phosphate PepB: pepB RlmB: rlmB deformylase: hutG reductase: nrdD spermidine dut nucleoside phosphorylase: diphosphate β transglycosylase: dgt MiaA: miaA 2-O- gshB HR45_RS02345 a peptide ACP synthase acyltransferase: HR45_RS08640 kinase: ndk reductase: reductase: formyltransferase/IMP cyclohydrolase: purH E: rne pyruvate fatty acid -oxidation I (generic) lipA dioxygenase AlkB: guanylyltransferase: beta- nucleoside triphosphate adenylosuccinate HR45_RS08435 mtgA 2251 RNase II Hyp dATP I: fabB HR45_RS04350 quinone- kinase: ndk a tRNA precursor kinase: pyk cobU methylguanosine ketoacyl- acetyl-CoA nrdA nrdB nrdA nrdB synthase: adenosine ribonuclease HR45_RS15920 6 + butanoate 4-nitrophenol FtsE dependent pyrophosphohydrolase: FAICAR purine-nucleoside with a 5' extension oleate a (3Z)-alk-3- a [2-oxoglutarate an N-terminal N -(3-methylbut- a proteinogenic FMNH NAD(P) in 23S rRNA substrate with beta-ketoacyl- ACP 1-acyl-sn-glycerol- carboxylase HR45_RS00010 dTTP pyrimidine/purine R: rnr an unsulfurated a tRNA Arg adenosyl-cobinamide a peptide 2 citrate gln AMP norophthalmate BamB dihydroorotate mazG phosphorylase: deoD and a long 3' trailer a tRNA precursor with pyruvate enoyl-CoA 5'-deoxyadenosine met dehydrogenase di-trans,octa-cis arginyl-[protein] 2-en-1-yl)- amino acid no poly-A tail RS16310 ACP synthase synthase 3-phosphate biotin carboxylase GTP bifunctional nucleoside phosphorylase: long-chain- [sulfur carrier] a peptidoglycan triphosphate 37 phosphate a butanoyl-[acp] adenosine E2 protein] N 6 -undecaprenyl a nucleobase 2'-deoxyguanosine adenosine II: fabF dehydrogenase: dUMP HR45_RS08435 a 5' extension and long-chain- formaldehyde succinate RS07290 I: fabB acyltransferase: subunit: dGDP phosphoribosylaminoimidazolecarboxamide fatty-acid-- -lipoyl-L-lysine diphosphate within DNA in tRNA pyrD adenine and adenylo-succinate a short 3' extension fatty-acid- beta-ketoacyl- a (5Z)-3-oxo- beta- HR45_RS09595 HR45_RS15260 thymidylate formyltransferase/IMP cyclohydrolase: purH purine-nucleoside ribonuclease CoA ligase a 1,2-diacyl- a [carboxyl-carrier PRPP adenosine salvage V ribonuclease -CoA ACP synthase tetradec-5-enoyl-[acp] ketoacyl- orotate anaerobic synthase: thyA adenylosuccinate adenosine deaminase: add 5-aminoimidazole ribonucleotide biosynthesis I phosphorylase: deoD R: rnr FadD: fadD a (2E)-2- RS18290 sn-glycerol protein dimer]-N 6 P protein ligase a 5-methylaminomethyl- RNase III mRNA an sn-glycero-3- GMP-N-ε-(N-α-acetyl β an [amino-group carrier II: fabF ACP ribonucleoside- nucleoside- lyase: purB IMP adenine ribonuclease long-chain fatty enoyl-CoA -D-fructofuranose a [protein]-L- β a [lipoyl-carrier a supercoiled a protein 3-oxoacyl-ACP dTMP ribonuclease component: geranyl 34 cob(II)inamide MoO - a peptide with a A ammonium H O γ -citryl-L- 6 DHAP RS04760 3-phosphate -carboxybiotinyl- Pentose Phosphate Pathways FadD: selenophosphate 2-thiouridine 2 processing phospho-N-(acyl) lysine methyl ester) 1-phosphate 2 protein]-C-terminal- - β protein]-N -[(R) with incorrect RS04835 beta-ketoacyl- synthase orotate triphosphate diphosphate D: rnd ribonuclease rnpA acid--CoA ligase: diphosphate ATP GTP leader sequence -isoaspartate glutamate duplex DNA IMP reductase L-lysine adenine dTMP kinase: PRPP D: rnd fadD in tRNA molybdopterin molybdopterin substrate ethanolamine 5'-phosphoramidate (L-glutamyl)-L-glutamate protein-L- -dihydrolipoyl]- NAD(P)H- replicative disulfide bonds RS17940 ACP synthase II: fabF phosphoribosyltransferase: reductase: nrdD kinase: ndk inosine adenine PH: rph HR45_RS16915 a 2,3,4-saturated FabG: fabG pyrimidine/purine HR45_RS03990 AMP a tRNA precursor with long-chain fatty acyl-CoA a 2,3,4- cofactor isoaspartate(D- L-lysine dihydrolipoyl dependent DNA pyrimidine 5'- I: fabB a (5Z)-3- pyrE phosphoribosyltransferase: apt pentose phosphate pathway fatty acid fructose- acetylglutamate 3-oxoacyl-ACP nucleoside a short 3' extension oleoyl-CoA acid--CoA ligase: dehydrogenase: saturated (3R)-3- hydroxylamine aspartate) O- dehydrogenase: glycerol-3- helicase: nucleotidase: oxododec- a CDP- dTDP pyrimidine/purine amidophosphoribosyltransferase: purF a tRNA precursor tRNA 2- cob(I)yrinic acid ribonuclease glycerophosphodiester purine nucleoside bisphosphate kinase: argB reductase phosphorylase: adenylate kinase: HR45_RS16915 HR45_RS03180 a 2,3,4- hydroxyacyl-CoA molybdenum cofactor reductase: hcp methyltransferase: N-formylglutamate lpdA phosphate dnaB yjjG RS07400 a 3-oxohexanoyl-[acp] 5-enoyl-[acp] diacylglycerol orotidine 5'- nucleoside phosphorylase: with a 5' extension D-glucopyranose a 2,3,4-saturated selenouridine(34) a,c-diamide III: rnc phosphodiesterase: phosphoramidase: aldolase class II: an [amino-group carrier a protein FabG: fabG fatty acid biosynthesis HR45_RS08435 nucleoside- HR45_RS07550 guanine and guanosine salvage II 5-phospho-β- AMP acyl-CoA [+ 2 isozymes] saturated (3S)-3- guanylyltransferase: HR45_RS06830 deformylase: hutG dehydrogenase: [+ 2 isozymes] [+ 3 isozymes] RS16180 3-oxoacyl- phosphate HR45_RS08435 gly 6-phosphate fatty acyl CoA synthase adenosyltransferase: HR45_RS01150 hinT HR45_RS10050 protein]-C-terminal- a protein L-β- dihydrolipoyl with correct RS14815 3-oxoacyl-ACP initiation (type II) purine-nucleoside diphosphate D-ribosylamine ribonuclease ribonuclease dehydrogenase: hydroxyacyl-CoA Carboxylate Degradation mobA γ gpsA a single inosine a (3R,5Z)-3-hydroxy- ACP xanthine and adenylate purine-nucleoside glucose-6- MnmH: mnmH cobO [+ 2 isozymes] -(5-phospho-L- isoaspartate dehydrogenase: disulfide bonds RS17215 reductase orotidine-5'- phosphorylase: kinase: ndk ribonuclease PH: rph D: rnd HR45_RS11555 RNase III sn-glycerol stranded DNA tetradec-5-enoyl-[acp] reductase dGTP xanthosine salvage kinase: adk phosphorylase: deoD phosphate hydroxylamine glutamyl)-L-glutamate α-methyl ester a [lipoyl-carrierlpdA α 6 FabG: fabG FabG: fabG 1-(3-sn- acetyl-CoA phosphate deoD dTTP guanosine phosphoribosylamine- P protein [+ 2 isozymes] 2-methylcitrate cycle II bis(guanylyl an mRNA fragment processing N- -acetyl lysine a leader sequence a peptide D-glyceraldehyde citrate glu protein]-N -[(R 3-phosphate 3-hydroxyacyl- dehydrogenase: pyruvate decarboxylation to acetyl CoA I a 5-methylaminomethyl- (2E)-3,7- adenosylcobinamide GMP DHAP phosphatidyl) decarboxylase: adenosine -glycine ligase: purD component: (2E,9Z)- coenzyme A 34 molybdopterin) product mRNA sn-glycerol an N- methyl ester 3-oxoacyl-ACP ACP dehydratase 3-oxoacyl- ADP hypoxanthine zwf 2-selenouridine dimethylocta- triphosphate )-lipoyl]-L-lysine MreD -sn-glycerol pyrF xanthosine superpathway of pyrimidine rnpA octadecenoyl-CoA acetyl-CoA C- cofactor 3-phosphate acylethanolamine reductase FabZ: fabZ ACP 6-phospho a 2,3,4-saturated a 2,3,4-saturated propanoate a [pyruvate in tRNA 2,6-diene-1-thiol RS18270 3-phosphate malonyl-CoA adenosine nucleobases salvage queuosine biosynthesis I (de novo) acyltransferase RS17240 FabG: fabG reductase UMP pyrimidine/purine ribonucleoside- ribonucleoside- hypoxanthine GAR D-glucono- fatty acyl CoA 3-oxoacyl-CoA dehydrogenase pyruvate bifunctional 3- deaminase: guanine FadA: fadA 6 RS17205 phosphatidylglycerophosphatase nucleoside diphosphate diphosphate phosphoribosyltransferase: uracil 1,5-lactone long-chain fatty E2 protein] N β a (3R)-3- hydroxydecanoyl- FabG: fabG ACP S- UMP add [+ 2 isozymes] pyruvate a peptidoglycan dimer with RNase E mRNA a 2'- an [RNA]-3'- D-sedoheptulose D-glycero- -D- a protein-L- a (3R,5Z)-3- A: HR45_RS18050 pyrimidine phosphorylase: reductase: reductase: HR45_RS09925 phosphoribosylglycinamide uracil preQ acid--CoA ligase: -lipoyl-L-lysine glutathione glycerophosphoserine sulfite GSSH (S)-2- chitin glyoxal hydroxyhexanoyl-[acp] ACP dehydratase/ malonyltransferase: hypoxanthine 0 6-phosphogluconolactonase: (S)-3-hydroxy-(9Z) dehydrogenase pentapeptide stems (meso- cob(II)alamin hypoglycin A processing deoxyribonucleoside glu ribonucleoside- 1-phosphate manno-heptose methionine- a protein an L-1- kinase: ribonucleosides salvage I formyltransferase: purN phosphoribosyltransferase: upp NADPH-dependent 7- HR45_RS16915 dihydrolipoyl ATP [DNA] aminobutanoate GTP XTP trans-2- hydroxydodec- fabD CMP inosine HR45_RS08435 nrdA nrdB nrdA nrdB phosphoribosyltransferase: hypoxanthine an uncharged tRNA pgl -octadecenoyl-CoA (acetyl- diaminopimelate containing) substrate 5'-triphosphate 2',3'- 1,7-bisphosphate (R)-S-oxide isoprenoid ModB bifunctional 3- phosphatidyl- pyrH UMP cyano-7-deazaguanine dehydrogenase: D-glycero- bifunctional zinc-dependent decenoyl-ACP 5-enoyl-[acp] cytidine phosphorylation purine-nucleoside ATP HR45_RS09925 phosphoribosyltransferase: hpt long-chain- transferring), cyclophosphate adenylate/guanylate inosine/ biosynthesis hydroxydecanoyl- 3-hydroxyacyl- sn-glycerol FGAR reductase QueF: queF D-gluconate lpdA thiosulfate beta-N- RNA 2',3'-cyclic fructose- beta-D-manno- methionine metalloprotease: RS12605 isomerase: fabA a malonyl-[acp] UDP phosphorylase: dADP UMP kinase: pyrH fatty-acid- homodimeric glycerophosphodiester cyclase domain- xanthosine glyoxalase RS18410 ACP dehydratase/ ACP CMP inosine/ hypoxanthine preQ 6-phosphate 1,6-anhydro-N- cob(I)yrinic acid gamma- ribonuclease DNA polymerase sulfurtransferase glutamate-- acetylhexosaminidase: phosphodiesterase: bisphosphate heptose 1,7- sulfoxide HR45_RS00265 nucleoside- uridine cytidine (d)CMP deoD IMP 1 acetyl-CoA -CoA dihydrolipoyl dihydrolipoyllysine-type: aceE phosphodiesterase: containing protein: triphosphatase: ElbB: elbB RS12670 trans-2- a (2E,5Z)-tetradeca- dehydratase guanosine kinase: xanthine phosphoribosyltransferase: hpt phosphoribosylformylglycinamidine NADP-dependent acetylmuramyl-L- a,c-diamide glutamyltransferase: ggt E: rne III subunit chi: GlpE: glpE cysteine ligase: nagZ thpR aldolase class II: bisphosphate 7- reductase [+ 2 isozymes] ketoacyl-ACP diphosphate kinase: udk deaminase: kinase: cmk anaerobic UDP 3-oxo-(9Z)- ligase dehydrogenase: residue HR45_RS01150 an [RNA]-3'- HR45_RS07360 yjjX decenoyl-ACP 2,5-dienoyl-[acp] FabZ: fabZ HR45_RS11625 synthase: purL tRNA guanosine(34) phosphogluconate a [pyruvate alanine amidase adenosyltransferase: gamma- HR45_RS12640 HR45_RS06745 HR45_RS10050 phosphatase: B/A protein: a peptide glycolate synthase III: kinase: ndk cdd CDP nucleoside- ribonucleoside- lipoprotein posttranslational modification octadecenoyl-CoA FadD: lpdA a [pyruvate acetyltransferase: [+ 2 isozymes] ribunucleoside- cyclic-GMP XDP isomerase: fabA gondoate biosynthesis GMP nucleoside- transglycosylase Tgt: tgt dehydrogenase: gndA dehydrogenase AmpD: ampD cobO glutamyltransferase: ggt [+ 11 isozymes] N-acetyl-D- D-glycero-β-D-gmhB HR45_RS04300 RS03145 bifunctional 3- HR45_RS14215 gln CMP diphosphate triphosphate FGAM acetyl-CoA C- fadD dehydrogenase HR45_RS03095 RNase E chitin 2'-phosphate a [protein]-L- UTP nucleoside- IMP diphosphate kinase: ndk D-ribulose 6 glutathione thiosulfate γ glucosamine manno-heptose 3-hydroxyacyl- (anaerobic) uridine a [prolipoprotein]- a 7-aminomethyl-7- 6 E2 protein] N -S- -L-glutamyl-(S)- BamC hydroxydecanoyl- ketoacyl-ACP kinase: ndk reductase: nrdD acyltransferase E2 protein] N dihydrolipoyllysine-- γ an mRNA fragment processing D-erythrose methionine RS08940 ACP dehydratase diphosphate UTP L-cysteine deazaguanosine 34 in tRNA 5-phosphate propanoyl-CoA acetyldihydrolipoyl- a peptidoglycan dimer with L-alanyl- -D-glutamyl- adenosylcobalamin sn-glycerol 2-aminobutanoate DHAP 1-phosphate ACP dehydratase/ synthase III: uridine phosphoribosylformylglycinamidine FadI: fadI dihydrolipoyl-L-lysine residue hypoglycin B L-cysteinylglycine product mRNA ser [DNA] GspI FabZ: fabZ CTP synthase: kinase: ndk L-lysine pentapeptide stem (meso- meso-2,6-diaminopimeloyl- triphosphate 3-phosphate trans-2- an oleoyl-[acp] HR45_RS19365 kinase: udk XMP cyclo-ligase: purM CTP synthase: prolipoprotein tRNA preQ1(34) S- [+ 2 isozymes] acetyltransferase: a (5Z)-tetradec-5-enoyl-[acp] beta-ketoacyl- HR45_RS06865 CTP ribulose- ribose-5- 2-methylcitrate diaminopimelate containing) D-alanyl-D-alanine decenoyl-ACP dATP HR45_RS06865 diacylglyceryl adenosylmethionine aceF a (2E)-hex-2-enoyl-[acp] isomerase: fabA ACP synthase an acetoacetyl-[acp] UMP AIR transferase: ribosyltransferase- phosphate 3- phosphate (7Z)-hexadecenoyl-CoA synthase: prpC RS14670 beta-ketoacyl- CTP CTP epimerase: isomerase I: fabB HR45_RS07335 isomerase QueA: queA (2S,3S)-2- UDP-N-acetyl-α-D-muramoyl- 32 an [L-cysteine a thiocarboxylated cyclic a 2'- a ribonucleoside 527 ACP synthase a (2E,5Z)-dodeca- acyl-CoA di-trans,octa-cis- quinoxaline-2- a cytosine a guanine a ribonucleoside a dipetide with an N- a mismatched RS09190 a [prolipoprotein]- rpe RpiA: rpiA methylcitrate L-alanyl-γ-D-glutamyl-L- aryl-carrier protein desulfurase]-S- [SAMP] C- pyranopterin deoxyribonucleoside ala pimeloyl-CoA acetyl-CoA a tripeptide 2',3'-cyclic RNA phenyl acetate a protein nitric oxide RS12105 beta-ketoacyl- 34 carboxyl adenylate in tRNA [DNA] in 16S rRNA triphosphate terminal L-aspartate DNA base pair I: fabB 3,5-dienoyl-[acp] an epoxyqueuosine in tRNA dehydrogenase: undecaprenyl phosphate terminal glycine phosphate 5'-triphosphate acetyl-CoA carboxylase CbiQ ACP synthase S-1,2-diacyl-sn- Fe/S-dependent lysyl-D-alanyl-D-alanine sulfanyl-L-cysteine phosphate bifunctional 2',3'- 16S rRNA anaerobic ATP- DNA beta-ketoacyl- D-xylulose D-ribose 5- HR45_RS11555 acetyl-CoA biotin carboxylase II: fabF glyceryl-L-cysteine tRNA 2-methylisocitrate cyclic-nucleotide 2'- (guanine(527)-N(7) ribonucleoside- dependent zinc mismatch ACP synthase an (11Z)-3-oxo- Carbohydrate Biosynthesis 5-phosphate phosphate [+ 2 isozymes] subunit: HR45_RS08640 a hexanoyl-[acp] acyl-CoA hydrolysis epoxyqueuosine(34) dehydratase phospho-N- acyl carrier tRNA 2- molybdopterin DNA polymerase 8-amino-7- peptidase phosphodiesterase/ )-methyltransferase triphosphate dipeptidase ribonuclease arylesterase: metalloprotease repair II: fabF icos-11-enoyl-[acp] signal (2E,7Z)- thiocytidine(32) T: pepT RsmG: rsmG PepE: pepE PH: rph HR45_RS05260 protein RS09005 reductase QueG: queG AcnD: acnD acetylmuramoyl- protein: acpP synthase: III subunit epsilon: oxononanoate acetyl-CoA carboxylase 3'-nucleotidase: an N 7 - a 2'- reductase: nrdD FtsH: ftsH a (5Z)-dodec- peptidase transketolase: tkt hexadecenoyl-CoA synthetase MutS: mutS nitrate porin beta-ketoacyl- a (7Z)-3-oxo- 3-oxoacyl-ACP a 2,3,4-saturated gluconeogenesis I 2-methyl-trans pentapeptide- [+ 3 isozymes] moaD moaE HR45_RS14220 synthase: biotin carboxylase HR45_RS14475 methylguanine 527 deoxyribonucleoside a peptide a properly Pal CMP-3-deoxy-D- α PRPP biosynthesis 34 ACP synthase hexadec-7-enoyl-[acp] 5-enoyl-[acp] reductase GDP-L-fucose UDP- -D-glucose II: lspA a queuosine in tRNA transferase: mraY TtcA: ttcA subunit: HR45_RS15260 a ribonucleoside fatty acyl CoAacyl-CoA O-antigen building blocks biosynthesis (E. coli) manno-octulosonate -aconitate [+ 12 isozymes] HR45_RS05085 in 16S rRNA 5'-triphosphate matched FeoB II: fabF FabG: fabG biosynthesis I (from biosynthesis D-sedoheptulose D-glyceraldehyde pyruvate fermentation to acetate IV a proteinogenic a dipeptide 3'-phosphate a proteinogenic a nucleoside RNA acetate phenol 3-oxoacyl-ACP thioesterase: (S)-malate biosynthesis D-ribose 5- an (S-diacyl-sn- 2-methylaconitate a quinoxaline-2- a [SAMP] C- malonyl-CoA asp DNA base pair α α GDP-D-mannose) a lipoprotein 7-phosphate 3-phosphate a 2-thiocytosine 32 an [L-cysteine molybdopterin amino acid amino acid diphosphate beta-ketoacyl- reductase 3-oxoacyl-ACP HR45_RS03460 UDP- -D- -D- D-glucopyranose GDP-α-D- D-ribulose D-glucopyranose phosphate glyceryl)-L-cysteinyl- (S)-3-hydroxy-(7Z) cis-trans undecaprenyl-diphospho-N- UMP carboxyl-[aryl- terminal glycine (8S)-8-amino-7- ribose-phosphate signal peptide γ AMP desulfurase]- RS05850 ACP synthase FabG: fabG reductase galactose glucopyranose 6-phosphate 5-phosphate 6-phosphate Cell Structure Biosynthesis [apolipoprotein] -hexadecenoyl-CoA pyruvate acetylmuramoyl-L-alanyl- -D- carrier protein] in tRNA [DNA] coenzyme A [+ 3 isozymes] malate UDP- glucose-6- mannose D-arabinose alpha-D-glucose pyrophosphokinase: peptidoglycan biosynthesis I (meso-diaminopimelate containing) signal peptide transaldolase: tal isomerase L-cysteine oxononanoate I: fabB FabG: fabG a 2,3,4-saturated 1-phosphate GDP- lipid IV biosynthesis (P. putida) lipid IV biosynthesis (E. coli) Kdo8N transfer to lipid IV 6 37 glutamyl-L-lysyl- D-alanyl-D-alanine RS01965 3-oxoacyl-ACP galactopyranose glucose-1-phosphate phosphate-specific HR45_RS16055 A A Kdo transfer to lipid A apolipoprotein N- N -L-threonylcarbamoyladenosine PrpF: prpF BamA fatty acid dehydrogenase: phosphate mannose 4,6- 5-phosphate α peptidase reductase stearate biosynthesis a (3R,11Z)-3-hydroxy- mutase: glf thymidylyltransferase phosphoglucomutase: PRPP UDP-N-acetyl- -D-glucosamine a (3R)-3- IV II (Haemophilus) CMP-8-amino- acyltransferase: lnt -modified tRNA biosynthesis cis-2- formate C- RS18615 a 3-oxooctanoyl-[acp] HR45_RS11295 isomerase: dehydratase: isomerase: a (3R)-3- A SppA: sppA D-erythrose II (bacteria and plants) α 966 32 FabG: fabG icos-11-enoyl-[acp] UDP-Galf RfbA: rfbA HR45_RS02635 UDP-N-acetylglucosamine hydroxydecanoyl- UDP-N-acetyl- 3,8-dideoxy- an N-acyl-(S-diacyl- F6P methylaconitate acetyltransferase: UDP-N-acetyl- -D- an all-trans- all-trans- a ribonucleoside a guanine a uridine [+ 2 isozymes] dTDP-α-D-glucose pgi gmd aldehydo-D-HR45_RS00195 hydroxytetradecanoyl- UDP-N-acetyl- CMP-Kdo lipid IV (E. coli) 4-phosphate 3-oxo-(7Z)- di-trans,octa-cis- a proteinogenic leukotriene-C4 3-methylbutanoate methanethiol O-succinyl-L- 1,4-dihydroxy- 1,4-dihydroxy- a 9S rRNA fumarate 3'-AMP a phenyl acetate Ins(1,4,5)P starch GDP-4-dehydro- A α muramoyl-L-alanyl-γ-D- polyisoprenyl tridecaprenyl asp a protein 3 thr 3-oxoacyl-ACP a (3R,7Z)-3-hydroxy- 3-hydroxyacyl- F6P phospho- 1-carboxyvinyltransferase: [acp] α-D-glucosamine [acp] α-D-glucosamine -D-manno- sn-glyceryl)-L- a peptide thr bifunctional pflB undecaprenyl phosphate amino acid homoserine 3'-phosphate in 16S rRNA in tRNA dTDP- α-D-rhamnose arabinose 5- lipid IV (E. coli) hexadecenoyl-CoA glutamyl-L-lysyl-D-alanine 2-naphthoate diphosphate diphosphate 2-naphthoate 16S rRNA tRNA (cytosine(32) bifunctional 2',3'- Obg family RS14380 reductase hexadec-7-enoyl-[acp] a palmitoyl-[acp] ACP dehydratase pyruvate sugar mutase: murA octulosonate A cysteinyl-[lipoprotein] threonylcarbamoyl- transketolase: tkt aconitate bifunctional 2',3'- HyaD/HybD family inosine/ threonine phosphate acetyl-CoA C- (guanine(966)-N(2) /uridine(32)-2'-O)- FabG: fabG beta-ketoacyl- FabZ: fabZ oxaloacetate glucose 4,6- glutamine-- GDP-L-fucose HR45_RS06030 acyl-ACP--UDP-N- acyl-ACP--UDP-N- lipid IV(A) 3- AMP synthase: hydratase 2/2- superpathway of acetate acetate- cyclic-nucleotide 2'- cyclic-nucleotide 2'- hydrogenase xanthosine ammonia- GTPase RS01450 3-hydroxyacyl- ACP synthase dehydratase: fructose-6- synthase: α-D-glucopyranose UDP-N-acetyl-α-D-glucosamine-enolpyruvate acyltransferase acetyl-CoA formate cystathionine ribonuclease L-aspartate )-methyltransferase methyltransferase phosphodiesterase/ arylesterase: CgtA: cgtA RS09855 α acetylglucosamine O- acetylglucosamine O- deoxy-D-manno- HR45_RS17665 D-glyceraldehyde methylisocitrate utilization and formation phospho-N- gamma- -CoA 1,4-dihydroxy- 1,4-dihydroxy- phosphodiesterase/ maturation triphosphatase: lyase, 3-oxoacyl-ACP ACP dehydratase bifunctional 3- phosphoenolpyruvate 1-phosphate UDP- -D-galactofuranose FadI: fadI gamma- E: rne oxidase: RsmD: rsmD TrmJ: trmJ HR45_RS05260 LapB II: fabF fatty acid elongation -- saturated rfbB phosphate HR45_RS13405 UDP-N-acetylmuramate acyltransferase: lpxA acyltransferase: lpxA octulosonic acid 3-phosphate dehydratase: acnB acetylmuramoyl- glutamyltransferase: ggt ligase: acs 2-naphthoate 2-naphthoate 3'-nucleotidase: an N 2 - a 2'-O- 3'-nucleotidase: endopeptidase: yjjX biosynthetic: a cyclodextrin reductase FabZ: fabZ hydroxydecanoyl- synthase: ppsA biosynthesis threonylcarbamoyl- [+ 2 isozymes] phosphate synthase: metB nadB beta-ketoacyl- dTDP-4-dehydro- transaminase GDP-4-dehydro- D-arabinofuranose UTP--glucose- glu dehydrogenase: murB transferase: waaA α-Kdo8N- N-end rule pathway I (prokaryotic) acetate pentapeptide- gamma- polyprenyltransferase: polyprenyltransferase: HR45_RS14475 methylguanine 966 methyluridine 32 HR45_RS14475 HR45_RS03270 Ins(1,4)P ilvA FabG: fabG ACP dehydratase/ β ala AMP synthase: Fe/S-dependent acetyltransferase: pta 2 bifunctional 3- ACP synthase 6-deoxy-α-D- (isomerizing) 6-deoxy- - 5-phosphate 1-phosphate α UDP-3-O-[(3R)-3- UDP-3-O-[(3R)-3- (2->6)-lipid IV acetate--CoA transferase: mraY glutamyltransferase: ggt HR45_RS15225 HR45_RS15225 a ribonucleoside in 16S rRNA in tRNA trans-2- UDP- -D-glucose UDP-N-acetyl-α-D-muramate peptidoglycan maturation (meso-diaminopimelate containing) A HR45_RS05365 (5Z)-tetradecenoyl-CoA 2-methylisocitrate a peptide 2-oxobutanoate RS05755 a (3R)-3- hydroxydecanoyl- I: fabB an acetoacetyl-[acp] phosphoenolpyruvate glucopyranose : glmS L-galactose 3-deoxy-8- uridylyltransferase hydroxydecanoyl]- hydroxymyristoyl]-N- α-Kdo-(2->6)- leucyl/ (L-threonylcarbamoyl) ligase: acs 3-methylbutanoyl- a 5S rRNA an rRNA fragment adenosine acetate a phenol decenoyl-ACP UDP-glucose 4- glutamate racemase: α 3-deoxy-D-manno- dehydratase acetyl phosphate acetate kinase: diphosphate met succinate 2-iminosuccinate succinate RS00900 hydroxyoctanoyl-[acp] ACP dehydratase/ a 3-oxooctadecanoyl- D-glucosamine GDP-L-fucose phosphooctulonate GalU: galU N-acetyl- -D- acetyl-α-D-glucosamine lipid IV (E. coli) lipid II (meso phenylalanyl- adenylate undecaprenyl-diphospho-N AMP CoA RS00905 isomerase: fabA dTDP-4- epimerase GalE: galE HR45_RS14620 UDP-N-acetylmuramate- A octulosonic acyl-CoA HR45_RS05305 UMP α γ trans-2- [acp] phosphopyruvate synthase: glucosamine UDP-3-O-acyl-N- diaminopimelate containing) tRNA--protein AcnD: acnD γ an -( -L-glutamyl) DMKH DMKH2-13 PspC dehydrorhamnose 6-phosphate synthase: kdsA α 3-deoxy-D-manno- acid kinase: tRNA (adenosine(37)-N6)- dehydrogenase: -acetylmuramoyl-L-alanyl- - leukotriene-D4 2 bifunctional 3- UDP- -D-glucose UDP-glucose 4- -L-alanine ligase: murC UDP-3-O-acyl-N- acetylglucosamine acetate kinase: -L-amino acid decenoyl-ACP 3-oxoacyl- a (2E,11Z)-icosa- hydratase: eno 3,5-epimerase: rfbC phosphoglucosamine HR45_RS13405 octulosonic monofunctional HR45_RS16825 transferase: threonylcarbamoyltransferase HR45_RS03180 (2R,3S)-2- acetyl phosphate acetyl-CoA D-glutamyl-L-lysyl- D-alanine hydroxydecanoyl- epimerase GalE: galE D-glt acetylglucosamine deacetylase: lpxC a [protein] HR45_RS05305 isomerase: fabA ACP 2,11-dienoyl-[acp] dTDP-4-dehydro- KDO-8P α α acid kinase: biosynthetic an N-terminal aat complex dimerization methylisocitrate ACP dehydratase/ mutase: glmM GDP-β-L-fucose UDP- -D-galactose UDP-N-acetyl- -D-muramoyl-L-alanine deacetylase: lpxC UDP-3-O-(3- 4-O-phospho- N-terminal L- [+ 2 isozymes] RS12240 reductase a 3-oxoacyl-[acp] 2-phospho-D-glycerate β-L-rhamnose HR45_RS16825 peptidoglycan α arginyl-[protein] subunit type 1 TsaB: tsaB β trans-2- a (2E,7Z)-hexadeca- phosphoglucosamine UDP-3-O-(3- -Kdo8N- (2E,5Z)- acetate N-acetyl- -D-glucosamine- all-trans- 6 2552 34 an insertion RNase II UDP-galactopyranose hydroxymyristoyl) α leucyl-L-arginine methylisocitrate an acyl-[acyl- a [DNA]-3'- a [histone]-N - uridine a cytidine CTP RS11075 2,7-dienoyl-[acp] FabG: fabG dTDP-4- 3-deoxy- UDP-N-acetylmuramoyl- 4-O-phospho- - transglycosylase: (2->6)-lipid IV [+ 2 isozymes] hydrogen selenide a proteinogenic glutathione 1,6-anhydro-N- decaprenyl 1,4-dihydroxy- NaMN 3'-GMP sequence L(or D)-O- degradation roseoflavin RS17040 decenoyl-ACP 2,3-bisphosphoglycerate- mutase: glmM mutase: glf hydroxydecanoyl) -α-D-glucosamine A tetradecenoyl-CoA phosphate O-acetyl-L-serine hydroxyl acetyl-L-lysine in 23S rRNA in tRNA manno- Kdo-(2->6)-lipid IV mtgA an N 6 -L- lyase: prpB amino acid carrier protein] β dGMP phosphoserine dCTP isomerase: fabA 3-oxoacyl- 3-oxoacyl-ACP independent dehydrorhamnose α-D-glucosamine L-alanine--D-glutamate -α-D-glucosamine UDP-3-O-(3- A acetyl- -D-muramate diphosphate 2-naphthoate bifunctional 23S rRNA tRNA (cytidine(34) bifunctional 2',3'- element IS30 substrate mRNA bifunctional RS07830 leucyl/ 37 acetyltransferase: pta transposase: deaminase: ACP reductase: rfbD octulosonate-8- UDP-Galf ligase: HR45_RS16365 a nascent peptidoglycan threonylcarbamoyladenine metallophosphatase/ (uridine(2552)-2'-O) -2'-O)- phosphoserine riboflavin 3-hydroxyacyl- a gondoyl-[acp] reductase phosphoglycerate 1-phosphate Kdo transfer UDP-3-O-(3- hydroxymyristoyl) phenylalanyl- histone cyclic-nucleotide 2'- HR45_RS18690 ribonuclease dcd reductase dTDP-β-L- phosphatase with (L-alanyl-γ-D-glutamyl- in tRNA pyruvate succinate O-acetylhomoserine exodeoxyribonuclease 5'-deoxynucleotidase: 5'-nucleotidase: -methyltransferase methyltransferase: phosphatase kinase/FAD ACP dehydratase beta-ketoacyl- FabG: fabG mutase: bifunctional UDP-N- to lipid IV hydroxymyristoyl) glucosamine N- tRNA--protein gamma- phosphate beta-N- 1,4-dihydroxy- deacetylase: phosphodiesterase/ transposase: R: rnr FabG: fabG rhamnose KdsC: kdsC meso-diaminopimelate UDP-N-acetyl-α-D-muramoyl- A meso-2,6-diaminopimeloyl-D- III: xthA yfbR SerB: serB synthetase: UTP RS05710 FabZ: fabZ ACP synthase 3-oxoacyl-ACP HR45_RS08670 IV (P. putida) glucosamine N- acyltransferase: superpathway of glycolysis and the Entner-Doudoroff pathway (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) aminocarboxypropyltransferase/ glutamyltransferase: ggt acyltransferase acetylhexosaminidase: 2-naphthoate HR45_RS06285 a 2'-O- RlmE: rlmE a 2'-O- HR45_RS09390 3'-nucleotidase: a (7Z)-hexadec-7-enoyl-[acp] a (3R)-3- acetylglucosamine L-alanyl-D-glutamate alanyl-D-alanine) pentapeptide transferase: exodeoxyribonuclease HR45_RS05800 an insertionHR45_RS19275 a nucleoside 5'- ribF α lipid IV acyltransferase: lpxD a [protein] cysteine synthase: HR45_RS04890 PlsX: plsX nagZ [+ 2 isozymes] 2552 34 HR45_RS14475 RS00085 I: fabB reductase diphosphorylase/ -Kdo CMP-Kdo A aat 3,5-dienoyl-CoA -tetradecenoyl-CoA gamma- polyprenyltransferase: β methyluridine methylcytidine sequence IS30 serine porin hydroxyoctadecanoyl- 3-phospho-D-glycerate (P. putida) lpxD UDP-2-N,3-O-bis[(3R)- an N-terminal D-glucopyranose [+ 2 isozymes] I: sbcB 2'-deoxyguanosine -D- monophosphate roseoflavin a (2E)-oct-2-enoyl-[acp] beta-ketoacyl- beta-ketoacyl- FabG: fabG glucosamine-1- Calvin-Benson-Bassham cycle D-ala UDP-N-acetylmuramoyl- N-terminal L- acyl-CoA glutamyltransferase: ggt HR45_RS15225 in 23S rRNA in tRNA with integrated RS10540 [acp] 3-deoxy-manno- UDP-2-N-[(3R)-3- 3-hydroxytetradecanoyl]- penicillin-binding penicillin-binding L-lysyl-[protein] 6-phosphate ribosylnicotinate guanosine 5'-phosphate ACP synthase ACP synthase phosphoglycerate phosphate N- L-alanyl-D-glutamate-- leucyl-L-lysine thioesterase: acetate a [histone]-L-lysine transposon bifunctional 3- octulosonate lipid IV(A) hydroxydodecanoyl]- α-D-glucosamine protein 2: mrdA protein 2: mrdA 1,6-anhydro-N- GlcNAc a 2'- a 2,3,4-saturatedII: fabF a (3R)-3-hydroxyacyl- acetyltransferase HR45_RS03460 acyl-carrier protein an acyl phosphate β a [DNA]-3'- I: fabB hydroxydecanoyl- 3-hydroxyacyl- kinase: CO cytidylyltransferase: D-alanine--D-alanine 2, 6-diaminopimelate 3-O-[(3R)-3- a mature peptidoglycan with Alcohol Degradation acetate L-selenocysteine an α-(γ-L-glutamyl) acetyl- -muramate deoxyribonucleoside fatty acyl-[acp] [acyl-carrier protein] 2 3-deoxy- UDP-2,3- D-alanyl-D-alanine D-alanyl-D-alanine 3-oxo-(5Z)- L-cysteinylglycine hydroxyl DMKH2-10 RsxA ACP dehydratase HR45_RS10055 GlmU: glmU D-ribulose-1,5- ligase: HR45_RS11230 ligase: murE γ [+ 3 isozymes] beta-ketoacyl- ACP dehydratase/ ribulose-1,5- kdsB D-manno- hydroxydecanoyl]- diacylglucosamine carboxypeptidase/ carboxypeptidase/ (L-alanyl- -D-glutamyl-meso- tetradecenoyl-CoA -L-amino acid 5'-monophosphate FabZ: fabZ N-acetyl-α-D- bisphosphate RS11685 ACP synthase trans-2- bisphosphate α octulosonic α-D-glucosamine diphosphatase: D-alanyl-D-alanine- D-alanyl-D-alanine- 2,6-diaminopimeloyl-D-alanyl- glucose-6- (3E,5Z)- acetyl-CoA C- ethanol Na + OadA Na + RS00055 an octanoyl-[acp] 13-DPG glucosamine CMP-Kdo D-alanyl-D-alanine UDP-N-acetyl- -D-muramoyl-L-alanyl- ethanol glycerophosphodiester glycerol degradation II glycerol degradation V II: fabF decenoyl-ACP bifunctional 3- CMP-pseudaminate biosynthesis carboxylase D-alanine) pentapeptide phosphate tetradecadienoate degradation II 4 γ-D-glutamyl-meso-2,6-diaminopimelate acid UDP-2,3- HR45_RS10185 endopeptidase: dacB endopeptidase: dacB acyltransferase degradation I an O - all-trans- all-trans- 46 1498 (R)-4-hydroxy- an oxidized isomerase: fabA 1-phosphate degradation 5-methoxy-6- a [protein]- (1S,2R)-1- a guanine a uracil cytidine a (9Z)-3-oxo- hydroxydecanoyl- small subunit: transferase: diacylglucosamine dehydrogenase: FadA: fadA NaMN glycyl-glycine glutathione methylthymine nonaprenyl dodecaprenyl 1,4-dihydroxy- canavaninosuccinate an adenine in DNA cyclic-AMP 4-methyl-2- nitroaromatic beta-ketoacyl- type I UDP-N-acetyl-α-D-glucosamine bifunctional UDP-N- UDP-2,3- ethanol glycerol glycerol methylbenzimidazole L-cysteine 4-hydroxybenzoate ser C-(indol-3- dAMP in tRNA in 16S rRNA mutated tRNA GTP octadec-9-enoyl-[acp] 3-hydroxyacyl- ACP dehydratase/ HR45_RS18910 UDP-N-acetylmuramoyl- waaA diphosphatase: a nascent peptidoglycan a nascent peptidoglycan zwf [+ 2 isozymes] ethanol in DNA diphosphate diphosphate 2-naphthoate Dam family site- tRNA 16S rRNA oxoglutarate compound uridine ACP synthase glyceraldehyde- UDP-N-acetylglucosamine acetylglucosamine diacylglucosamine γ a glycerophosphodiester glycerol glycerol yl)glycerol 3',5'-cyclic-AMP putative 4- NADH:ubiquinone Syd ACP trans-2- tripeptide--D-alanyl-D- HR45_RS10185 with (L-alanyl- -D-glutamyl- with D,D cross-links (meso- bifunctional NAD(P)H II: fabF 3-oxoacyl-ACP 3-phosphate Kdo transfer to diphosphatase: (3Z)-dodec- bifunctional glycerophosphodiester dehydrogenase: dehydrogenase: 3-phosphate specific DNA- (guanosine(46)-N7) (uracil(1498)-N(3))- phosphodiesterase: ribonuclease diguanylate kinase: udk + + dehydratase decenoyl-ACP 4,6-dehydratase diphosphorylase/ phosphoribulokinase: alanine ligase: murF α-Kdo-(2->6) meso-2,6-diaminopimeloyl- diaminopimelate containing) acetaldehyde- nicotinate-nucleotide-- gamma- 5'-deoxynucleotidase: hydroxy-4-methyl- nitroreductase: Na reductase (Na(+) Na RS00425 reductase dehydrogenase: D-ribulose 3-phospho- lipid IV I (E. coli) UDP-2,3- HR45_RS05945 3-enoyl-CoA acetaldehyde- phosphodiesterase: HR45_RS07580 HR45_RS07580 methylated-DNA-- 4-hydroxybenzoate 1,4-dihydroxy- argininosuccinate (adenine-N6)- -methyltransferase methyltransferase: cpdA R: rnr cyclase: RS15335 beta-ketoacyl- isomerase: fabA (inverting): pseB glucosamine-1- HR45_RS10590 -lipid IV A D-alanine) tetrapeptide CoA/alcohol dimethylbenzimidazole glutamyltransferase: ggt 2-oxoglutarate HR45_RS04735 -transporting) FabZ: fabZ A CoA/alcohol [protein]-cysteine S- tryptophan yfbR lyase: argH methyltransferase: TrmB: trmB rsmE CMP ACP synthase FabG: fabG gap UDP-2-acetamido-2,6-dideoxy- phosphate N- 5-phosphate ribose-5- D-glycerate α diacylglucosamine 6-phospho dehydrogenase: HR45_RS01150 dihydroxyacetone dihydroxyacetone octaprenyltransferase: 2-naphthoate an N 7 - an N 3 - aldolase: a reduced HR45_RS13890 a 2,3,4-saturated a trans-2-enoyl- β UDP-N-acetyl- -D-muramoyl-L- (P. putida) CMP-Kdo lipid IV (E. coli) lipid X dehydrogenase: phosphoribosyltransferase: gamma- methyltransferase: synthase: HR45_RS17260 a nucleoside 5'- a (2E)-octadec- -L-arabino-hex-4-ulose phosphate A diphosphatase: [+ 2 isozymes] ubiA polyprenyltransferase: 46 1498 nitroaromatic [+ 15 isozymes] I: fabB 3-oxoacyl-ACP glyceraldehyde- acetyltransferase alanyl-γ-D-glutamyl-meso-2,6- D-glucono- adhE cobT 6 methylguanine methyluracil AMP HR45_RS11135 fatty acyl-[acp] [acyl-carrier protein] isomerase di-trans,octa-cis-undecaprenyl phosphate HR45_RS05945 a mature peptidoglycan adhE sn-glycerol glutamyltransferase: ggt HR45_RS12145 trpB trpA an N -methyladenine monophosphate c-di-GMP NADH:ubiquinone reductase 2-enoyl-[acp] 3-phosphate UDP-4-amino-4, 6-dideoxy- GlmU: glmU phosphoglycerate GDP-mannose biosynthesis diaminopimeloyl-D-alanyl-D-alanine lipid-A- 1,5-lactone glucose-6- acetaldehyde HR45_RS15225 2'-deoxyadenosine in tRNA in 16S rRNA pyruvate compound RpiA: rpiA with D,D cross-links (meso- (2E)-dodec- acetaldehyde 3-phosphate in DNA Na + reductase (Na(+) Na + RS17100 a 3-oxodecanoyl-[acp] FabG: fabG triose-phosphate dehydrogenase: N-acetyl-beta-L-altrosamine UDP-N-acetyl- ribulose- kinase: lipid IV(A) 3- disaccharide a nascent peptidoglycan a nascent peptidoglycan with a nascent peptidoglycan a mature peptidoglycan phosphate L-canavanine fumarate D-ribose 5- D-glucopyranose α-Kdo-(2->4)-α- lipid X (P. putida) diaminopimelate containing) 6-phosphogluconolactonase: 2-enoyl-CoA 5-methoxy-6- γ 3-nonaprenyl-4- D-glyceraldehyde -transporting) isomerase: HR45_RS02960 transaminase: pseC α phosphate 3- HR45_RS10055 phospho-N-acetylmuramoyl- deoxy-D-manno- synthase: lpxB with L,D cross links (meso- (L-alanyl-γ-D-glutamyl-meso- with (L-alanyl-γ-D-glutamyl- with (L-alanyl-γ-D-glutamyl- isomerase: -L-glutamyl- a [protein]-S- RS00895 a (3R,9Z)-3-hydroxy- -D-glucosamine phosphate 6-phosphate Kdo-(2->6)-lipid pgl bifunctional DHAP DHAP methylbenzimidazole nicotinate L-cysteinylglycine a thymine in DNA hydroxybenzoate 3-phosphate trp RS09745 3-oxoacyl-ACP HR45_RS12730 UDP-4-amino-4,6-dideoxy- epimerase: glucose-6- pentapeptide- octulosonic acid lipid-A- lipid A disaccharide diaminopimelate containing) 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- meso-2,6-diaminopimeloyl- pgi glycylglycine methyl-L-cysteine DMK-12 octadec-9-enoyl-[acp] D-glyceraldehyde β IV (P. putida) D-gluconate acetaldehyde- ribotide phosphate reductase DHAP N-acetyl- -L-altrosamine D-xylulose rpe transketolase: tkt phosphate transferase: mraY A transferase: waaA disaccharide (E. coli) glycine) tetrapeptide D-alanine) tetrapeptide a stearoyl-[acp] phosphatidylserine and 3-phosphate 13-DPG 6-phosphate CoA/alcohol FabG: fabG 3-hydroxyacyl- phosphatidylethanolamine UDP-4-amino-4, 6-dideoxy- 5-phosphate isomerase: pgi synthase: lpxB acetate DHAP CysW 2+ 2+ D-sedoheptulose (S)-3- dehydrogenase: 6 Zn RS06115 Zn ACP dehydratase N-acetyl-beta-L-altrosamine undecaprenyldiphospho-N-acetylmuramoyl- α-Kdo-(2->6)- phosphogluconate an O - all-trans- all-trans- 2030 32 37 a 5,6- 4-hydroxy- RNase G a (1->4)- 3-oxoacyl-ACP biosynthesis I F6P lipid A hydroxydodecanoyl-CoA adhE an N 10 - a [protein]- a peptidoglycan a ribonucleoside adenine a uridine guanine a ribonucleoside uridine cellulose 7-phosphate a mature peptidoglycan a mature peptidoglycan with 5-methoxybenzimidazole NaMN an L-methionyl- 20 histidinol FabZ: fabZ N-acetyltransferase: pseH L-alanyl-γ-D-glutamyl-meso-2,6- lipid IV (E. coli) dehydratase: acetate--CoA methylguanine heptaprenyl undecaprenyl 1,4-dihydroxy- dimer (generic) Phe dihydrouracil 4-methyl-2- degradation α-D-glucan reductase transketolase: tkt A disaccharide γ Met formyltetrahydrofolate L-cysteine 4-hydroxybenzoate in 23S rRNA in tRNA in tRNA diphosphate RS15375 a CDP-diacylglycerol biosynthesis mannose-1-phosphate with L,D cross-links (meso- (L-alanyl- -D-glutamyl-meso- a mature peptidoglycan [initiator tRNA ] 2-naphthoate 5'-monophosphate 1,4-alpha- RS01105 FabG: fabG bifunctional 3- fructose- UDP-2,4-diacetamido-2,4,6- diaminopimeloyl-D-alanyl-D-alanine (P. putida) lipid IV (E. coli) HR45_RS11530 ligase: acs acetyl-CoA in DNA diphosphate diphosphate bifunctional 23S rRNA bifunctional tRNA tRNA in tRNA tRNA ribonucleoside- oxoglutarateputative 4- substrate mRNA histidinol uridine CDP-diacylglycerol--serine β A diaminopimelate containing) 2,6-diaminopimelate) tripeptide with (L-alanyl-γ-D-glutamyl- ribonuclease glucan hydroxydecanoyl- bisphosphate trideoxy- -L-altropyranose guanylyltransferase/ undecaprenyldiphospho- (adenine(2030)-N(6) pseudouridine(32) (guanosine(37)-N1) diphosphate dehydrogenase: kinase: udk a (3R)-3- O-phosphatidyltransferase: cellulose meso-2,6-diaminopimeloyl- KDGP acetyl-CoA nicotinate-nucleotide-- lytic murein metallophosphatase/ dihydrouridine(20/ hydroxy-4-methyl- G: rng branching FtsB ACP dehydratase/ stearate aldolase class II: UDP-2,4-diacetamido- D-sedoheptulose mannose-6- muramoylpentapeptide beta-N- α α TCA cycle TCA cycle I (prokaryotic) methylated-DNA-- 4-hydroxybenzoate 1,4-dihydroxy- )-methyltransferase synthase/23S rRNA -methyltransferase reductase: hisD hydroxydecanoyl-[acp] pssA UDP- -Kdo-(2->4)- -Kdo- glycine) tetrapeptide 3-oxododecanoyl-CoA dimethylbenzimidazole methionyl-tRNA transglycosylase: 5'-nucleotidase: 20a) synthase 2-oxoglutarate ribonuclease protein UMP CysZ HR45_RS10050 phosphate isomerase: C1 Compound Utilization and Assimilation [protein]-cysteine S- RlmJ: pseudouridine(746) 1 TrmD: trmD trans-2- a 3-sn-phosphatidyl- 2,4, 6-trideoxy-beta- forming 1,7-bisphosphate D-glyceraldehyde acetylglucosaminyltransferase: (2->6)-lipid IV (E. coli) lipid IV phosphoribosyltransferase: formyltransferase: fmt octaprenyltransferase: 2-naphthoate HR45_RS14325 HR45_RS06285 an N - DusA: dusA a 2'- nrdA nrdB aldolase: E: rne long-chain- F6P HR45_RS13395 A A GlgB: glgB bifunctional 3- L-serine L-altropyranose murG methyltransferase: ubiA 6 HR45_RS08900 synthase RluA: rluA 37 20 his decenoyl-ACP 3-phosphate acetyl-CoA C- polyprenyltransferase: [+ 3 isozymes] an N - 32 methylguanine a uracil in tRNA deoxyribonucleoside HR45_RS11135 fatty-acid-- cellulose (P. putida) acetyl-CoA bifunctional cobT HR45_RS12145 [+ 4 isozymes] a pseudouridine an mRNA fragment RS15585 hydroxydecanoyl- isomerase: fabA hydrolase: pseG fructose- D-mannopyranose HR45_RS15225 2030 Phe a GlgE-glycogen RS06590 CoA ligase phosphatidylserine synthase lipid II (meso diaminopimelate containing) 4-hydroxy-2- acyltransferase formaldehyde oxidation formate a ribonucleoside methyladenine in tRNA in tRNA 5'-diphosphate pyruvate ACP dehydratase/ β 2,4-diacetamido-2,4,6- class 1 fructose- bisphosphate 6-phosphate formate assimilation into 5,10- formaldehyde oxidation an N-formyl- a (2E,9Z)-octadeca- FadD: fadD decarboxylase: psd -D-fructose 1,6- catalytic triose-phosphate oxoglutarate FadI: fadI VII (THF pathway) oxidation to CO 3-heptaprenyl-4- GlcNAc-1,6- in 23S rRNA β bisphosphatase: oxaloacetate methylenetetrahydrofolate II (glutathione-dependent) 2 a tetrahydrofolate RsxD trans-2- bisphosphate trideoxy- -L-altropyranose subunit: aldolase class II: phosphomannomutase: [+ 2 isozymes] 5-methoxybenzimidazole nicotinate L-methionyl- a [protein]-S- a lipid II 2,9-dienoyl-[acp] long-chain fatty an L-1- isomerase: 2-methylcitrate aldolase/2- met a guanine in DNA hydroxybenzoate anhydro-MurNAc- decenoyl-ACP pseudaminic acid HR45_RS10270 HR45_RS10050 HR45_RS13390 F6P formaldehyde ribotide phosphate [initiator tRNA ] methyl-L-cysteine DMKH2-11 TatC acid--CoA ligase: phosphatidylethanolamine class 1 fructose- bcsA HR45_RS12730 synthase: prpC dehydro-3-deoxy- formate formaldehyde formate pentapeptide isomerase: fabA bisphosphatase: synthase: pseI α malate dehydrogenase decanoyl-CoA HR45_RS16915 cellulose -D-mannose citrate synthase: phosphogluconate class 1 fructose- formate-- formate 3-hydroxyacyl- HR45_RS10270 β-D-fructose 1,6- (quinone): mqo RS05475 pseudaminate DHAP 1-phosphate HR45_RS05150 aldolase: bisphosphatase: acyl-CoA a 5,10- tetrahydrofolate dehydrogenase: RS02475 ACP dehydratase bisphosphate malate dehydrogenase a single a [protein]- a DNA methyl all-trans- uridine 746 a [release factor]- a guanine 37 D-myo-inositol succinate a [protein]- a glucosylated stearoyl-CoA mannose-1-phosphate malate dehydrogenase: HR45_RS11525 dehydrogenase: ligase: S-(hydroxymethyl) HR45_RS14990 5-hydroxybenzimidazole NaMN glycerophosphoglycerol carbamoyl uroporphyrinogen-III a [protein] (L-serine/L- pyridoxamine FabZ: fabZ F6P pseudaminic acid Secondary Metabolite Biosynthesis (quinone): mqo HR45_RS10270 methylenetetrahydrofolate stranded DNA L-cysteine phosphotriester hexaprenyl L-ornithine in 23S rRNA L-glutamine in tRNA (1,3,4,5)- semialdehyde L-tyrosine glycogenin an oleoyl-[acp] guanylyltransferase/ HR45_RS11295 HR45_RS11555 HR45_RS14145 glutathione HR45_RS15010 4-hydroxybenzoate phosphate threonine) phosphate 5'-phosphate 1,4-alpha- RS07720 cytidylyltransferase: pseF bifunctional β-D-fructose 1,6- bifunctional 10 diphosphate uroporphyrinogen-III bifunctional tRNA peptide chain tRNA tetrakisphosphate NADP-dependent phosphate long-chain fatty glucose-6- [+ 2 isozymes] an N - protein inosine/ phosphotyrosine pyridoxamine RS05300 a (2E)-dec-2-enoyl-[acp] CMP-pseudaminate mannose-6- methylerythritol phosphate pathway I methylerythritol phosphate pathway II 4-hydroxy-2- bisphosphate [+ 2 isozymes] methylenetetrahydrofolate S-(hydroxymethyl) [+ 4 isozymes] C-methyltransferase: pseudouridine(32) release factor (guanosine(37)-N1) succinate- glucan acid activation phosphate formyltetrahydrofolate CO nicotinate-nucleotide-- exodeoxyribonuclease methylated-DNA-- glycerophosphodiester phosphatase xanthosine protein 5'-phosphate phosphate isomerase: autoinducer AI-2 biosynthesis I oxoglutarate DHAP glutathione 2 cobA synthase/23S rRNA N(5)-glutamine -methyltransferase semialdehyde branching fructose- (S)-malate citrate fructose- (2E)-dec-2-enoyl-CoA dehydrogenase/ bifunctional 4-hydroxybenzoate ornithine CheZ: triphosphatase: phosphatase: RS07605 isomerase: pgi HR45_RS13395 aldolase/2- dehydrogenase/ dimethylbenzimidazole VII large subunit: xseA [protein]-cysteine S- phosphodiesterase: pseudouridine(746) methyltransferase: TrmD: trmD dehydrogenase: oxidase: pdxH protein FlgH a long-chain fatty acid bisphosphate D-glyceraldehyde D-glyceraldehyde bisphosphate methenyltetrahydrofolate octaprenyltransferase: carbamoyltransferase: [+ 2 isozymes] an N 1 - HR45_RS13525 D-myo-inositolyjjX HR45_RS09365 D-glucopyranose pyruvate pyruvate methylenetetrahydrofolate class III alcohol phosphoribosyltransferase: [+ 2 isozymes] methyltransferase: HR45_RS18165 GlgB: glgB aldolase class II: α 3-phosphate 3-phosphate dehydro-3-deoxy- triose-phosphate cyclohydrolase FolD: folD ubiA HR45_RS17740 precorrin-2 synthase RluA: rluA prmC 37 gabD a [protein]- PLP long-chain fatty GDP- -D-mannose SAM aldolase class II: dehydrogenase/ 746 5 methylguanine a [protein] Ser/Thr (1,3,4)- 6-phosphate phosphogluconate dehydrogenase: cobT HR45_RS12145 [+ 2 isozymes] a pseudouridine a [release factor]-N L-tyrosine CysT palmitoleate acid--CoA ligase: HR45_RS10050 bifunctional aconitate HR45_RS10050 isomerase: a 5,10- methenyltetrahydrofolate in tRNA trisphosphate succinate a glycogen biosynthesis I (from 1-deoxy-D- 1-deoxy-D- hydratase 2/2- aldolase: eda HR45_RS12730 HR45_RS03475 a single-stranded in 23S rRNA -methyl-L-glutamine RS18865 a decanoyl-[acyl-carrier protein] HR45_RS16915 (S)-3- methenyltetrahydrofolate cyclohydrolase FolD: folD a ribonucleoside 3-hexaprenyl-4- (5Z)-dodec-5-enoate) xylulose-5- xylulose-5- fumarate hydratase: methylisocitrate 5-hydroxybenzimidazole oligodeoxyribonucleotide a [protein]-S- long-chain-fatty- hydroxydecanoyl-CoA bifunctional a 5,10- S-formylglutathione nicotinate 5'-monophosphate [DNA] hydroxybenzoate glycerol sn-glycerol L-citrulline phosphate phosphate SAH HR45_RS03200 dehydratase: acnB D-glyceraldehyde ribotide phosphate methyl-L-cysteine RS07790 beta-ketoacyl- a (5Z)-dodec- acid--CoA ligase methylenetetrahydrofolate methenyltetrahydrofolate 3-phosphate RS14345 ACP synthase 5-enoyl-[acp] synthase: dxs synthase: dxs [+ 2 isozymes] 3-phosphate beta-ketoacyl- FadD: fadD 5'-methylthioadenosine/ dehydrogenase/ bifunctional S-formylglutathione II: fabF a long-chain fatty acyl-CoA fumarate cis-aconitate type I RS12245 ACP synthase adenosylhomocysteine methenyltetrahydrofolate methylenetetrahydrofolate hydrolase: fghA UDP-N-acetyl- an N-terminal L- 1-deoxy-D-xylulose 1-deoxy-D-xylulose bifunctional aconitate glyceraldehyde- decaprenyl-diphospho-N- 2-amino-6-[1-hydroxyethyl]- all-trans- sn-glycero-3- a peptide with uridine 955/2504/ a 3,5,7,9,11,13,15- a [protein]-α- a negatively 1,6-anhydro-N- type-1 an organic RS02720 beta-ketoacyl- I: fabB 3-oxodecanoyl-CoA cyclohydrolase FolD: folD α isobutanoate a phosphate 5-phosphate 5-phosphate nucleosidase: succinate dehydrogenase/ hydratase 2/2- 3-phosphate dehydrogenase/ formate -D-glucosamine acetylmuramoyl-pentapeptide 7-methyl-7,8-dihydropterin 4-hydroxybenzoate decaprenyl phosphoethanolamine an N-terminal 2580 in 23S rRNA alanyl-[S18 protein hepta-oxo- L-glutamate supercoiled DNA acetyl-β-muramate transmembrane hydroperoxide a protein ACP synthase an N 10 - monoester beta-ketoacyl- Amino Acid Biosynthesis HR45_RS07395 fumarate reductase methenyltetrahydrofolate 2-amino-4-hydroxy-6- diphosphate Xaa-L-proline 23S rRNA of 30S ribosome] hexadecanoyl-[PKS-acp]aldo/keto protein-glutamate O- DNA anhydro-N- proteins thiol I: fabB 1-deoxy-D-xylulose- 1-deoxy-D-xylulose- methylisocitrate dehydrogenase: fatty acid formyltetrahydrofolate ribosomal protein rhomboid family alkaline MshL ACP synthase iron-sulfur subunit: cyclohydrolase FolD: folD undecaprenyldiphospho- hydroxymethyldihydropteridine pseudouridine(955/ reductase: methyltransferase topoisomerase III: acetylmuramic peroxidase: LptD 5-phosphate 5-phosphate S-ribosyl-L-homocysteine dehydratase: acnB gap oxidation glycerophosphodiester S18-alanine N- intramembrane phosphatase: endopeptidase II: fabF HR45_RS10505 formyltetrahydrofolate a 5,10- muramoylpentapeptide beta-N- diphosphokinase: folK acetate--CoA 4-hydroxybenzoate leucyl 2504/2580) HR45_RS03700 CheR: HR45_RS04550 acid kinase: tpx a 3-oxododecanoyl-[acp] a (7Z)-3-oxotetradec- superpathway of L- reductoisomerase: reductoisomerase: glyceraldehyde- complex phosphodiesterase: acetyltransferase: serine protease HR45_RS00975 La: lon ModB L-histidine biosynthesis superpathway of L-methionine L-lysine biosynthesis I superpathway of branched chain amino acid biosynthesis superpathway of L-homoserine ammonia assimilation cycle III deformylase: purU methylenetetrahydrofolate acetylglucosaminyltransferase: 2-amino-4-hydroxy-6- ligase: acs octaprenyltransferase: aminopeptidase: synthase RluC: rluC HR45_RS13730 [+ 2 isozymes] HR45_RS07430 [+ 2 isozymes] 7-enoyl-[acp] isoleucine biosynthesis I ispC ispC succinate dehydrogenase: subunit alpha 955/ an N-terminal N-acetyl-rimI 9-hydroxy-3,5,7,11,13,15-[+ 3 isozymes] a [protein]-L- N-acetyl-D- cleaved type-1GlpG: glpG [+ 3 isozymes] biosynthesis (by sulfhydrylation) superpathway of L- L-arginine biosynthesis I (via L-ornithine) S-ribosylhomocysteine 3-phosphate HR45_RS01150 a pseudouridine RS14665 3-oxoacyl-ACP and L-methionine biosynthesis sdhA sdhC murG hydroxymethyldihydropteridine ubiA pepA L-alanyl-[S18 protein glutamate-O 5 a relaxed DNA muramate 6- an alcohol a peptide 3-oxoacyl- asparagine biosynthesis lyase: luxS dehydrogenase: FadJ: fadJ formate [+ 2 isozymes] 2504/2580 in 23S rRNA hexaoxohexadecanoyl- transmembrane an alcohol reductase oxaloacetate MEP MEP diphosphokinase: folK of 30S ribosome] -methyl-ester phosphate ACP PRPP oxaloacetate asp pyruvate thr ammonium succinate D-threo-isocitrate HR45_RS02960 [+ 4 isozymes] [1-(2-amino-7-methyl-4-oxo- [PKS-acp] proteins GspD FabG: fabG aspartate/ asp decaprenyl-pyrophosphoryl- isobutanoyl-CoA diphosphate RS18260 reductase bifunctional glu AI-2 NADP-dependent UDP 7,8-dihydro-3H-pteridin- AMP 3-decaprenyl-4- a peptide with tyrosine/aromatic ATP asp acetolactate 2-C-methyl-D- 2-C-methyl-D- octanoyl-CoA (N-acetylglucosamine)-N- sn-glycerol a proteinogenic 3-oxoacyl-ACP FabG: fabG aspartate/ aspartate kinase/ threonine 2-oxoglutarate glu isocitrate dehydrogenase: 13-DPG Carbohydrate Degradation 6-yl)]ethyl diphosphate hydroxybenzoate ethanolamine an N-terminal aminotransferase: phosphoribosyltransferase: synthase: amino-acid N- bifunctional aspartate glutamate- erythritol 4-phosphate erythritol 4-phosphate ADP-forming succinate- acetylmuramyl-(pentapeptide) 3-phosphate amino acid RS02670 reductase tyrosine/aromatic homoserine ammonia- glutamate HR45_RS04095 L-proline 3-oxoacyl- HR45_RS02745 hisG HR45_RS04610 acetyltransferase: kinase/homoserine -ammonia cytidylyltransferase: cytidylyltransferase: -CoA ligase: sucD sucC acyl-CoA RS09020 FabG: fabG aminotransferase: asparagine asparagine dehydrogenase lyase, synthase large phosphoglycerate ACP ilvN argA dehydrogenase ligase: glnA ispD ispD dehydrogenase: Entner-Doudoroff pathway I aspartate/ β HR45_RS02745 synthase synthase II: HR45_RS00475 biosynthetic: subunit: gltB imidazole kinase: D-mannose degradation a (3R)-3- reductase 1-(5-phospho- -D-ribosyl)-ATP II: HR45_RS00475 4-(cytidine 5'- 4-(cytidine 5'- (2R,4S)-2-methyl-2,4- HR45_RS11555 glycogen degradation II a [glycine-cleavage an N-terminal L- a Chi-site containing a RecA DNA all-trans- a cytosine 1407 cytidine 2',3'-cyclic uridine 2'3'-cyclic a cytidine a uracil 747 an adenine 34 RS04820 tyrosine/aromatic acetolactate N-acetyl-L- glycerol HR45_RS10055 an L-arginyl- an isoprenoid 1,4-dihydroxy- 3'-cmp RS18115 hydroxydodecanoyl-[acp] aspartate/ B: asnB B: asnB [+ 2 isozymes] ilvA diphospho)-2-C- diphospho)-2-C- dihydroxydihydrofuran-3-one D-glucopyranose a sulfurated [sulfur carrier] SAM complex H protein] double stranded recombination 4-hydroxybenzoate GGPP hexaprenyl monophosphate monophosphate 32 met ethylphosphate repressor LexA FabG: fabG synthase 2: [+ 2 isozymes] phosphate [+ 2 isozymes] D-mannopyranose aspartyl-[protein] [tRNA Arg ] diphosphate 4-aminobenzoate in 16S rRNA in tRNA in 23S rRNA in tRNA aminotransferase: bifunctional glutamate 3-phospho- 6 2-naphthoate bifunctional 2',3'- bifunctional 2',3'- a (3R,7Z)-3- tyrosine/aromatic L-aspartyl-4-phosphate (2Z)-2-aminobut- methyl-D-erythritol methyl-D-erythritol 6-phosphate N -octanoyl-L-lysine DNA with a blunt end and repair protein diphosphate 16S rRNA tRNA (cytosine(32) 23S rRNA bifunctional 2',3'- alkaline tRNA bifunctional 3- HR45_RS10860 phosphoribosyl- aminotransferase: HR45_RS17810 ammoniumsynthase: gln 4-(cytidine 5'- 4-(cytidine 5'- succinyl-CoA 2-oxoglutarate D-glycerate (2E)-oct-2-enoyl-CoA 6-phosphate a glycogen cyclic-nucleotide 2'- cyclic-nucleotide 2'- cyclic-nucleotide 2'- amino-acid N- SecE hydroxydecanoyl- hydroxytetradec- ilvM 2-enoate acetylglutamate L-aspartyl-4-phosphate hisH hisF glucose-6- mannose-1-phosphate (cytosine(1407)-C(5) /uridine(32)-2'-O)- (uracil(747)-C(5))- phosphatase: adenosine(34) repressor GspJ 7-enoyl-[acp] asp AMP cyclohydrolase/ HR45_RS10860 asn asn diphospho) diphospho) 2,3-bisphosphoglycerate- guanylyltransferase/ 4-hydroxybenzoate 1,4-dihydroxy- )-methyltransferase phosphodiesterase/ phosphodiesterase/ methyltransferase methyltransferase phosphodiesterase/ acetyltransferase: deaminase ACP dehydratase/ aspartate- kinase: argB [+ 5 isozymes] (2R,4S)-2-methyl-2,3,3,4- phosphate glycogen/starch/ lipoyl arginyltransferase: exodeoxyribonuclease 4-hydroxybenzoate phoA LexA: lexA 3-hydroxyacyl- phosphoribosyl-ATP (S)-2-acetolactate -2-C-methyl- -2-C-methyl- independent mannose-6- octaprenyltransferase: 2-naphthoate RsmF: rsmF 3'-nucleotidase: 3'-nucleotidase: TrmJ: trmJ RlmC: rlmC 3'-nucleotidase: argA TadA: tadA trans-2- semialdehyde dehydrogenase: alpha-glucan HR45_RS04070 octaprenyltransferase: 1407 a 2'-O- 747 [+ 3 isozymes] ACP bifunctional diphosphatase HisIE: asp aspartate-semialdehyde D-erythritol D-erythritol tetrahydroxytetrahydrofuran phosphoglycerate synthase: lipA V: recC recB recD ubiA a 5-methylcytosine HR45_RS14475 HR45_RS14475 a 5-methyluracil HR45_RS14475 N-acetyl-L- a hypoxanthine cleaved RS17300 dehydrogenase: N-acetylglutamyl- zwf phosphate isomerase: phosphorylase: polyprenyltransferase: ubiA 32 RS14855 decenoyl-ACP dehydrogenase: methylcytidine ethanol 34 dehydratase aspartate kinase/ HR45_RS03875 ketol-acid phosphate kinase: ispE kinase: ispE mutase: (S)-3- HR45_RS13395 HR45_RS15225 in 16S rRNA 3'-cmp 3'-UMP in 23S rRNA cytidine methionine in tRNAs repressor LexA isomerase: fabA HR45_RS14605 2-iminobutanoate HR45_RS14605 6-phospho HR45_RS02235 an N-terminal in tRNA FabZ: fabZ homoserine bifunctional reductoisomerase: glu 2-phospho-4-(cytidine 2-phospho-4-(cytidine 2-oxoglutarate HR45_RS08670 hydroxyoctanoyl-CoA F6P a [glycine-cleavage a double stranded DNA RS18665 1-(5-phospho-β-D-ribosyl)-AMP N-acetyl- D-glucono- a tRNA Arg L-arginiyl-L- a 4-hydroxy-3- 3-all trans- 3-hydroxyacyl- dehydrogenase aspartate kinase/ L-aspartate 4- ilvC 5'-diphospho)-2-C- 5'-diphospho)-2-C- dehydrogenase E1 an α-limit dextrin 5'-deoxyadenosine 6 an unsulfurated RS08930 bifunctional 3- gamma- L-aspartate 4-semialdehyde 2-phospho- 1,5-lactone met complex H protein] N aspartyl-[protein] with a RecA protein polyprenylbenzoate hexaprenyl-4- ACP dehydratase II: HR45_RS00475 homoserine semialdehyde (2R)-2,3- methyl-D-erythritol methyl-D-erythritol component: sucA -[(R)-lipoyl]-L-lysine [sulfur carrier] loaded 3' overhang demethylmenaquinol-4 hydroxydecanoyl- bifunctional dihydroxy-3- glutamyl- 2-C-methyl-D- 2-C-methyl-D- preQ biosynthesis D-glycerate 6-phosphogluconolactonase: 4-alpha- aminobenzoate FabZ: fabZ [+ 2 isozymes] dehydrogenase 4-hydroxy- 0 RS16275 ACP dehydratase/ phosphoribosyl- methylbutanoate phosphate bifunctional aspartate erythritol 2,4- erythritol 2,4- phosphopyruvate pgl glucanotransferase: RS08220 trans-2- AMP cyclohydrolase/ II: HR45_RS00475 tetrahydrodipicolinate 2-oxobutanoate 3-oxooctanoyl-CoA a (2E)-dodec-2-enoyl-[acp] L-aspartyl- dihydroxy-acid reductase: kinase/homoserine cyclodiphosphate cyclodiphosphate hydratase: eno D-gluconate malQ decenoyl-ACP phosphoribosyl-ATP [+ 2 isozymes] synthase: a [pyruvate dehydrogenase E2 an N-terminal L- an N-terminal a 2'- a cytidine 2498 5-(methylsulfanyl) 4-phosphate argC dehydrogenase synthase: ispF synthase: ispF GTP a debranched an L-arginyl- an L-arginyl- a peptide with a methyl red [DNA] oxaloacetate 54 3'-UMP an oligopeptide an unfolded dehydratase: acetolactate acetyl-CoA C- 6-phosphate 6 [DNA] deoxyribonucleoside a uracil in tRNA -2,3-dioxopentyl a 28S rRNA RS18535 isomerase: fabA diphosphatase HisIE: HR45_RS02580 phosphoenol α a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine glutamyl-[protein] Arg 3-sulfo-L- Arg in 23S rRNA L-aspartyl- superpathway of L-methionine (2S,4S)-4- ilvD synthase: N-acetyl-L- II: HR45_RS00475 GTP -limit dextrin [tRNA ] [tRNA ] penultimate glycine protein GspG aspartate- HR45_RS03875 2-C-methyl-D-erythritol- 2-C-methyl-D-erythritol- pyruvate acyltransferase phosphogluconate alanyl-[protein] 5'-monophosphate 23S rRNA DNA polymerase 2-methylcitrate tRNA bifunctional 2',3'- 1-phosphate RICIN domain- a (2E,7Z)-tetradeca- 4-phosphate biosynthesis (transsulfuration) hydroxy-2,3,4,5- HR45_RS04610 glutamate 5- bifunctional aspartate cyclohydrolase oligopeptidase semialdehyde 1-(5-phospho-β-D-ribosyl)- 3-methyl-2- 2,4-cyclodiphosphate 2,4-cyclodiphosphate 2-oxoglutarate decarboxylation to succinyl-CoA Respiration FadI: fadI dehydratase: 5'-deoxynucleotidase: (cytidine(2498)-2'-O) III subunit epsilon: synthase: prpC (uridine(54)-C5)- cyclic-nucleotide 2'- acireductone containing chaperonin 2,7-dienoyl-[acp] sulfate tetrahydrodipicolinate ilvN semialdehyde kinase/homoserine 7,8- I FolE: folE phosphoenolpyruvate pyruvate D-galactose degradation I (Leloir pathway) glycogen/starch/ FMN-dependent A: prlC RS13845 dehydrogenase: 5-[(5-phosphoribosylamino) aspartate- oxobutanoate N-acetylornithine [+ 2 isozymes] HR45_RS11530 arginyltransferase: exodeoxyribonuclease yfbR -methyltransferase HR45_RS14220 citrate synthase: methyltransferase phosphodiesterase/ synthase: mtnC protein: GroEL: groL oxaloacetate 4-hydroxy- dehydrogenase I: thrA flavodoxin- flavodoxin- dihydroneopterin synthase: ppsA kinase: pyk alpha-glucan arginyltransferase: carboxypeptidase: NADH- a dodecanoyl-[acp] acetolactate a [2-oxoglutarate β lipoyl synthase: lipA I: sbcB RlmM: rlmM [+ 5 isozymes] HR45_RS05150 TrmA: trmA 3'-nucleotidase: HR45_RS00810 HR45_RS14605 methylideneamino]imidazole- semialdehyde sulfate hydrogencarbonate aminotransferase: dependent dependent 3'-triphosphate -D- phosphorylase: HR45_RS04070 a 2-O- a 2'- 54 1,2-dihydroxy-5- tetrahydrodipicolinate 2-isopropylmalate branched-chain synthase 2: dehydrogenase hexanoyl-CoA KDGP D-glucopyranose HR45_RS04070 HR45_RS12160 azoreductase: a 2'- 1,2-dihydroxypropane- a 5-methyluracil HR45_RS14475 a peptide a 28S rRNA LolE 4-carboxamide dehydrogenase: adenylyltransferase: aspartate/ HR45_RS10670 L-homoserine (E)-4-hydroxy- (E)-4-hydroxy- pyruvate galactopyranose HR45_RS02235 methylcytidine 2498 deoxyribonucleoside (methylsulfanyl) a protein L-aspartate 4- reductase: dapB synthase: leuA 6-carboxytetrahydropterin 6 HR45_RS09510 deoxyribonucleoside 1,2,3-tricarboxylate in tRNA fragments RS03555 1-(5-phosphoribosyl)-5- HR45_RS14605 cysN cysD tyrosine/aromatic amino acid HR45_RS17810 glutamine- E2 protein] N 2-oxoglutarate uridine pent-1-en-3-one beta-ketoacyl- semialdehyde N-acetyl-L- 3-methylbut- 3-methylbut- synthase: HR45_RS03640 acyl-CoA galactose an N-terminal a 2'- in 23S rRNA 5'-monophosphate a (7Z)-tetradec- (S)-2,3,4,5- aminotransferase: ilvM hydrolyzing -lipoyl-L-lysine α Arg an N-terminal L- [(5- phosphoribosylamino) L-aspartate 4- aminotransferase: ornithine 2-enyl- 2-enyl- dehydrogenase dehydrogenase: mutarotase: -D- a [pyruvate dehydrogenase a tRNA L-arginiyl-L- deoxyribonucleoside [DNA] ACP synthase bifunctional APS tetrahydrodipicolinate (2S)-2- homoserine O- bifunctional 5'-deoxyadenosine Arg a peptide with a 7-enoyl-[acp] HR45_RS13795 (S)-2-aceto-2- carbamoyl- 6-carboxy-5,6,7,8- 2-oxoglutarate E1 component: glucopyranose met 6 an unsulfurated [sulfur carrier] a tRNA arginiyl-3-sulfo- an amino acid N,N-dimethyl-1,4- methylideneamino]imidazole-4- semialdehyde HR45_RS02745 succinyltransferase: metA diphosphate diphosphate HR45_RS11555 4-hydroxy-2- HR45_RS00730 E2 protein] N -lipoyl-L-lysine glutamyl-[protein] 5'-monophosphate C-terminal glycine anthranilate II: fabF aspartate kinase/ 2,3,4,5- isopropylmalate hydroxybutanoate phosphate acetylornithine tetrahydropterin dehydrogenase sucA 1-phosphate L-alanyl-[protein] phenylenediamine laurate beta-ketoacyl- carboxamide isomerase: hisA adenylyl- aspartate/ synthase: ispG synthase: ispG [+ 2 isozymes] oxoglutarate galactose beta-ketoacyl- homoserine bifunctional tetrahydropyridine- 3-isopropylmalate synthase: deacetylase: 7-carboxy-7- E1 component: ACP synthase phosphoribulosylformimino- sulfate tyrosine/aromatic val ketol-acid cys O-succinyl-L-homoserine (E)-4-hydroxy-3- (E)-4-hydroxy-3- aldolase/2- mutarotase: GspH ACP synthase long-chain fatty dehydrogenase aspartate kinase/ 2,6-dicarboxylate N- dehydratase: carA carB argE deazaguanine sucA (2E)-hexenoyl-CoA alpha-D-glucose RS06045 I: fabB AICAR-phosphate kinase: aminotransferase: reductoisomerase: methylbut-2-en- methylbut-2-en- myo-inositol dehydro-3-deoxy- HR45_RS00835 α undecaprenyl-diphospho-N an N-terminal 1402 1939 34 I: fabB acid--CoA ligase: II: HR45_RS00475 homoserine succinyltransferase: leuD leuC synthase [+ 2 isozymes] phosphate-specific UDP-N-acetyl- -D-glucosamine 5-amino-4- an L-arginyl- a single- coenzyme A a glycogen a cytidine a holo [PedN acyl- a uracil an oligopeptide a [protein]-L- a supercoiled an adenosine ilvC carbamoyl 1-yl diphosphate 1-yl diphosphate a [2-oxoglutarate a [2-oxoglutarate α γ PRPP coenzyme A (E)-caffeoyl-CoA Arg2 a DNA segment beta-ketoacyl- cysC HR45_RS10860 L-ornithine biosynthesis phosphogluconate -D- -acetylmuramoyl-L-alanyl- - imidazolecarboxyamide 3-sulfino-L- Arg stranded RNA VibB in 16S rRNA in 23S rRNA proline (ω = 180) duplex DNA in [tRNA ] HR45_RS16915 bifunctional dehydrogenase dapD QueE: queE dehydrogenase dehydrogenase 2-oxoisovalerate decarboxylation to isobutanoyl-CoA phosphoglucomutase: [tRNA ] carrier protein] ACP synthase imidazole glycerol 2-isopropylmaleate (R)-2,3-dihydroxy- phosphate cystathionine gamma- 4-hydroxy- 4-hydroxy- aldolase: galactopyranose D-glutamyl-L-lysyl- D-alanine alanyl-[protein] glycogen debranching 16S rRNA 23S rRNA electron transfer peptidylprolyl ATP-dependent tRNA aspartate kinase/ II: HR45_RS00475 PAPS D-glucopyranose E2 protein] N 6 E2 protein] N 6 -S- HR45_RS02635 ACP S- oligopeptidase B: long-chain-fatty- II: fabF phosphate asp N-succinyl-2-amino- 3-methylpentanoate synthase: metB 3-methylbut- 3-methylbut- 7-carboxy-7- HR45_RS11525 undecaprenyldiphospho- protein: HR45_RS14425 (cytidine(1402)-2'-O) (uracil(1939)-C(5)) flavoprotein isomerase: DNA helicase: adenosine(34) recombinase a 3-oxotetradecanoyl-[acp] homoserine 3-isopropylmalate 6-phosphate -dihydrolipoyl- succinyldihydrolipoyl- an [apo BCAA galactokinase: phospho- malonyltransferase: HR45_RS09240 acid--CoA ligase synthase: hisH hisF bifunctional 6-ketopimelate dihydroxy-acid ornithine 2-enyl 2-enyl deazaguanine (S)-3- muramoylpentapeptide beta-N- adenine polyribonucleotide CoA pyrophosphatase: holo-ACP glycogen debranching -methyltransferase: -methyltransferase subunit alpha: HR45_RS14315 HR45_RS03835 deaminase RecA: recA GspF FadD: fadD a (9Z)-3-oxohexadec- dehydrogenase aspartate kinase/ phosphoadenylyl- dehydratase: diphosphate diphosphate L-lysine L-lysine dehydrogenase hydroxyhexanoyl-CoA bifunctional galK sugar mutase: arginyltransferase: fabD bifunctional aspartate N-succinyldiaminopimelate dehydratase: carbamoyltransferase: 7-cyano-7- 6 phosphoribosyltransferase: apt nucleotidyltransferase: pnp HR45_RS03210 synthase: protein GlgX: glgX rsmI RlmD: rlmD HR45_RS18140 [+ 11 isozymes] [+ 4 isozymes] TadA: tadA a DNA segment 3-oxoacyl-ACP 9-enoyl-[acp] sulfate reductase: E2 protein] N acetylglucosaminyltransferase: a 2'-O- a malonyl[PedN 1939 34 RS10835 I: thrA homoserine aminotransferase: leuD leuC L-cystathionine reductase: reductase: alpha-ketoacid 4-hydroxy-2- HR45_RS06030 HR45_RS04070 HR45_RS07245 a 5-methyluracil a [protein]-L- a single an inosine reductase kinase/homoserine ilvD HR45_RS17740 4-hydroxy- 4-hydroxy- deazaguanine α-D-galactose murG a maltodextrin 1402 hydrocaffeoyl-CoA a peptide in reverse lauroyl-CoA AICAR D-erythro-1-(imidazol-4- HR45_RS01410 Ins(3)P -lipoyl-L-lysine dehydrogenase oxoglutarate UDP-α-D-glucose methylcytidine acyl-carrier in 23S rRNA proline (ω = 0) stranded DNA in [tRNA Arg2 ] FabG: fabG 3-oxoacyl- dehydrogenase dehydrogenase HR45_RS10670 (2R,3S)-3- 3-methylbut- ispH 3-methylbut- ispH synthase 1-phosphate orientation L-homoserine yl)-glycerol 3-phosphate (3S)-3-methyl-2- dihydrolipoyl subunit beta: aldolase/2- D-glucopyranose a single- in 16S rRNA protein] ACP I: thrA sulfite II: HR45_RS00475 N-succinyl-L,L-2,6- isopropylmalate cystathionine beta- 2-enyl 2-enyl QueC: queC 2-oxoglutarate ditrans,octacis-undecaprenyldiphospho- AICAR an N-terminal L- a nucleoside 4'-phosphopantetheine 3-oxoacyl-ACP oxopentanoate IPP IPP inositol-1- dehydrogenase: HR45_RS03100 dehydro-3-deoxy- 6-phosphate UDP stranded RNA 3',5'-ADP 3',5'-ADP a holo-[VibB aryl- reductase bifunctional histidinol- diaminopimelate 3-isopropylmalate asp L-citrulline lyase: HR45_RS04385 diphosphate diphosphate dehydrogenase 3-oxohexanoyl-CoA N-acetyl-(N-acetylglucosaminyl)muramoyl- a tRNA Arg arginiyl-3-sulfino- diphosphate reductase [+ 2 isozymes] branched-chain preQ monophosphatase: lpdA phosphogluconate carrier protein] FabG: fabG homoserine phosphatase/ L-homoserine assimilatory dehydrogenase: superpathway reductase: reductase: 0 E1 component: γ L-alanyl-[protein] GspC FabG: fabG succinyl- amino acid suhB dihydrolipoyl L-alanyl- -D-glutamyl-L-lysyl-D-alanine 3-oxoacyl- kinase: thrB imidazoleglycerol- sulfite reductase leuB of L-threonine ispH ispH sucA acetyl-CoA C- aldolase: eda RS06085 L-aspartyl-4-phosphate diaminopimelate aminotransferase: L-homocysteine isopentenyl- isopentenyl- dehydrogenase: a (3R)-3- ACP phosphate (NADPH): argininosuccinate biosynthesis myo-inositol acyltransferase O-phospho- desuccinylase: (2S)-2-isopropyl- diphosphate diphosphate 2-oxoglutarate an [apo BCAA 1402 hydroxytetradecanoyl-[acp] dehydratase HR45_RS01400 HR45_RS13795 synthase: lpdA an [apo BCAA dehydrogenase FadI: fadI D-glyceraldehyde a [formate C UDP-N-acetyl-α-D-muramoyl- an apo [peptidyl- RNase R degradation an (R)-2- (2E,6E)-farnesyl UDP-4-amino-D-fucose a cytidine an organic reductase L-homoserine aspartate-semialdehyde dapE 3-oxosuccinate oxaloacetate 5-methyltetrahydropteroyltriglutamate- Delta- Delta- dehydrogenase dehydrogenase pyruvate a reduced flavodoxin SAM D-alanyl-D-alanine coenzyme A protoheme a holo [PedD acyl- a [protein] Ser/Thr L-ornithine Ins(1)P wound RNA DNA with lesion acetylene HisB: hisB cysI HR45_RS17745 E2 protein] N 6 -S-[2- [+ 2 isozymes] 3-phosphate UDP- 2-deoxy-D-glucose 6- acetyltransferase]-glycine L-alanyl-γ-D-glutamyl-L-lysine substrate RNA halocarboxylate diphosphate UDP-4-amino-4, 6- in 16S rRNA hydroperoxide FabG: fabG dehydrogenase: methionine isomerase: idi isomerase: idi 6 carrier protein] carrier protein] bifunctional 3- O-acetyl-L- ile aspartate/ - homocysteine S- complex E2 protein] N phosphate degradation 16S rRNA serine/threonine ATP-dependent excinuclease alkyl nitrogenase a (3R,9Z)-3- threonine 3-(imidazol-4-yl)-2- HR45_RS14605 L,L-diaminopimelate synthase: metH methylpropanoyl]dihydrolipoyl- type I glucose 4- dideoxy-N-acetyl- ACP S- arginine N- inositol-1- NlpI hydroxydecanoyl- homoserine hydrogen sulfide L-arginino- tyrosine/aromatic methyltransferase: metE dihydrolipoyllysine- -dihydrolipoyl- butanoyl-CoA (cytosine(1402)-N(4) protein kinase: RNA helicase ABC subunit hydroperoxide iron hydroxyhexadec- synthase: oxopropyl phosphate L-lysine glyceraldehyde- epimerase 2-deoxy-D- pyruvate formate UDP-N-acetylmuramoyl- HAD family beta-L-altrosamine malonyltransferase: succinyltransferase: monophosphatase: NhaA ACP dehydratase/ succinate aminotransferase: [+ 3 isozymes] residue L-lysine holo-ACP ribonuclease protoheme IX )-methyltransferase HR45_RS13775 RhlB: rhlB UvrA: uvrA reductase: protein: nifH 9-enoyl-[acp] thrC L-aspartate 4-semialdehyde 4-methyl-2- DMAPP DMAPP acyl-CoA 3-phosphate GalE: galE glucose 6- lyase 1-activating tripeptide--D-alanyl-D- hydrolase: transaminase: pseC fabD astA suhB trans-2- histidinol-phosphate diaminopimelate HR45_RS02745 succinyltransferase: synthase: R: rnr farnesyltransferase: 4 RsmH: rsmH [+ 3 isozymes] [+ 2 isozymes] ahpF ahpC [+ 2 isozymes] 3-hydroxyacyl- phosphate UDP-4-dehydro-6- an N - a malonyl- a [protein] (L-serine/L- 2 decenoyl-ACP O-acetylhomoserine oxopentanoate argininosuccinate dehydrogenase: dehydrogenase: UDP- hexitol protein: pflA alanine ligase: murF HR45_RS07245 HR45_RS01890 HR45_RS17410 N -succinyl- myo-inositol DNA without thr transaminase: epimerase: dapF aspartate/ met odhB α 1402 an unwound RNA an alcohol ethene ACP aminocarboxypropyltransferase/ bifunctional aspartate lyase: argH gap glucose 4- phosphatase deoxy- -D-glucose methylcytidine [PedD acyl- threonine) phosphate L-ornithine lesion isomerase: fabA HR45_RS03850 branched-chain tyrosine/aromatic HR45_RS11555 dehydratase cysteine synthase: HR45_RS04890 kinase/homoserine amino acid superpathway of L-serine epimerase 2-deoxy-HxpB: hxpB UDP-N-acetyl-α-D-muramoyl-L-alanyl- in 16S rRNA carrier protein] 3-hydroxyacyl- threonine meso-diaminopimelate aminotransferase: [+ 2 isozymes] glyceraldehyde- a [formate C acetyltransferase]- a holo [peptidyl- a diribonucleotide a nucleoside 5'- an (S)-2- MacB FabZ: fabZ dehydrogenase aminotransferase: arg and glycine biosynthesis I GalE: galE D-glucose 5'-deoxyadenosine a flavodoxin semiquinone met γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine 3',5'-ADP a halide anion ferroheme o ACP dehydratase ammonia- L-histidinol phosphate HR45_RS10860 3-phosphate glycin -2-yl radical carrier protein] monophosphate hydroxycarboxylate bifunctional 3- phosphatidylglycerol II: HR45_RS00475 HR45_RS13795 crotonyl-CoA PstA FabZ: fabZ lyase, L-homocysteine diaminopimelate asp 3-phospho-D-glycerate dehydrogenase: hydroxydecanoyl- biosynthesis I (plastidic) bifunctional histidinol- bifunctional aspartate L-tryptophan biosynthesis biosynthetic: decarboxylase: lysA HR45_RS02960 ACP dehydratase/ phosphatase/ kinase/homoserine leu L-phenylalanine phosphoglycerate a (2E)-tetradec-2-enoyl-[acp] ilvA 2-deoxy- α undecaprenyl-diphospho-N-acetylmuramoyl-L- 1618 a [protein]- RNase E DHAP 5-methyltetrahydropteroyltriglutamate- bifunctional biosynthesis I dehydrogenase: serA UDP-N-acetyl- -D-glucosamine D-glucopyranose maltopentaose a sulfurated + an (S)-2- ManNAc-GlcNAc- a 5' triphospho- adenine a double-stranded a double trans-2- imidazoleglycerol- methionine dehydrogenase I: thrA 13-DPG D-glucono- alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine hydrogen cyanide H hydrogencarbonate CDP-glycerol a holo [BryU acyl- an acyl phosphate Ins(6)P N-phospho- degradation CAIR NAD(P)H- (2Z)-2-aminobut- - homocysteine S- lys gln aspartate kinase/ 3-phosphooxypyruvate [sulfur carrier] halocarboxylate PP-undecaprenol [mRNA] in 23S rRNA oligonucleotide stranded DNA RS04135 decenoyl-ACP L-alanine phosphate synthase: chorismate (S)-3- 1,5-lactone 23S rRNA carrier protein] DNA L-histidine substrate mRNA 5-(carboxyamino) dependent 2-enoate methyltransferase: metE L-tyrosine biosynthesis I homoserine chorismate α undecaprenyldiphospho- RNA inositol-1- isomerase: fabA biosynthesis III dehydratase metH L-homoserine hydroxybutanoyl-CoA phosphoglycerate -D- α L-arabinose (adenine(1618)-N(6) ACP S- oligoribonuclease: acylphosphatase: topoisomerase phosphohistidine imidazole RS17760 glycerol-3- [+ 3 isozymes] dehydrogenase bifunctional 3-phosphoserine/ UDP- -D- muramoylpentapeptide beta-N- 4-alpha- carbonate HAD family pyrophosphohydrolase: monophosphatase: ribonuclease a (2E,9Z)-hexadeca- HisB: hisB kinase: glucopyranose degradation I thiosulfate )-methyltransferase malonyltransferase: orn HR45_RS18485 IV: parC parE phosphatase ribonucleotide phosphate anthranilate II: HR45_RS00475 chorismate mutase/ phosphohydroxythreonine galactose acetylglucosaminyltransferase: glucanotransferase: dehydratase: hydrolase: rppH suhB E: rne 2,9-dienoyl-[acp] cys homoserine O- chorismate HR45_RS10055 1-phosphate sulfurtransferase RlmF: rlmF fabD [+ 2 isozymes] SixA: sixA mutase: purE a myristoyl-[acp] dehydrogenase: histidinol met synthase component [+ 2 isozymes] prephenate transaminase: serC 2-deoxy-D- murG malQ can HR45_RS01890 a 5'-phospho- an N 6 - a malonyl- a nucleoside 5'- cysteine succinyltransferase: metA bifunctional 3-phospho- L-arabinopyranose GlpE: glpE a carboxylate myo-inositol a negatively a [protein]- an mRNA fragment gpsA 2-iminobutanoate 1: HR45_RS05375 dehydrogenase: alpha-D-glucose gluconate [mRNA] methyladenine 1618 [BryU acyl- monophosphate AIR desulfurase: chorismate mutase/ L-aspartyl- O-phospho-L-serine acetoacetyl-CoA D-glycerate L-arabinose supercoiled DNA L-histidine SecA beta-ketoacyl- sn-glycerol histidinol tyrA phosphate-specific Gro-P-ManNAc- in 23S rRNA carrier protein] HR45_RS10120 L-proline cys O-succinyl-L-homoserine prephenate 4-phosphate isomerase: ditrans,octacis-undecaprenyldiphospho-N- UDP maltose maltotetraose an (S)-2- CMP ACP synthase 3-phosphate dehydrogenase: hisD anthranilate dehydrogenase: prephenate acetyl-CoA C- phosphoglucomutase: thiocyanate an unsulfurated CO H O a halide anion GlcNAc-PP- RS05025 biosynthesis I L-methionine biosynthesis II PRPP araA acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- 2 2 hydroxycarboxylate II: fabF [+ 2 isozymes] phosphoserine acyltransferase HR45_RS02635 [sulfur carrier] undecaprenol a palmitoleoyl-[acp] glycerol-3- ala (from L-glutamate) tyrA aspartate- prephenate 3-dehydro- L-ribulose alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine beta-ketoacyl- histidinal phosphatase SerB: serB FadI: fadI 2-phospho- phospho- phosphate 1-O- cystathionine gamma- prephenate semialdehyde dehydratase: 2-deoxy-D- ACP synthase 2-oxobutanoate glu L-homoserine anthranilate D-glycerate sugar mutase: ribulokinase: acyltransferase histidinol synthase: metB dehydrogenase: pheA [+ 2 isozymes] gluconate I: fabB phosphoribosyltransferase: trpD bifunctional ser HR45_RS06030 HR45_RS00815 an apo-[LYS2 L- DNA combined with an (S)-2- (S)-3-hydroxy- a cytosine 967 a [protein]- PlsY: plsY glutamate 5- HR45_RS14605 phosphopyruvate dethiobiotin a sulfurated D-glucopyranose maltohexaose coenzyme A a ribonucleoside a single a holo [BryP acyl- a myo-inositol rhodopin π an L-arabinan thiosulfate riboflavin RS04660 acetolactate dehydrogenase: hisD chorismate mutase/ 3-phenyl-2- acetyl-CoA SAM 2-aminoadipyl- exogenous DNA to form halocarboxylate isobutanoate in 16S rRNA Ins(2)P N -phospho- glycerol-3- kinase: proB L-aspartate 4- hydratase: eno L-ribulose 5- [sulfur carrier] triphosphate stranded DNA carrier protein] monophosphate RS17860 a 3-oxohexadecanoyl-[acp] synthase: homoserine kinase: thrB prephenate oxopropanoate serine D-glucopyranose carrier-protein] a recombinational junction 3-hydroxyisobutyrate 16S rRNA carotenoid L-histidine arabinan endo- thiosulfate NAD(P) palmitoleate phosphate 1-O- glutamate 5- L-cystathionine N-(5-phosphoribosyl)-anthranilate semialdehyde phosphate Holliday junction ACP S- inositol-1- inositol-1- phosphohistidine HR45_RS04610 glycine his dehydrogenase: aspartate/ hydroxymethyltransferase: phosphoenol 6-phosphate 4-alpha- dehydrogenase: (cytosine(967)-C(5) 1,2-hydratase: 1,5-alpha-L- sulfurtransferase H-flavin acyltransferase γ kinase: proB L-ribulose-5- resolvase RuvX: ruvX HAD family malonyltransferase: monophosphatase: monophosphatase: phosphatase 3-oxoacyl-ACP ilvN biosynthesis IV -L-glutamyl bifunctional indole-3-glycerol- tyrA bifunctional tyrosine/aromatic HR45_RS18010 pyruvate biotin glucanotransferase: holo-ACP mmsB )-methyltransferase HR45_RS01600 arabinosidase: GlpE: glpE reductase: PlsB: plsB 5-phosphate cystathionine beta- O-phospho-L-homoserine phosphate 4- crossover junction hydrolase: DNA primase: fabD suhB suhB SixA: sixA HR45_RS00920 reductase acetolactate phosphate synthase TrpC/ 3-(4- aspartate kinase/ aminotransferase: synthase malQ synthase: (S)-methylmalonate- RsmB: rsmB 1,1'-dihydroxy-1,1',2,2'- α fre a 1-acyl-sn lyase: HR45_RS04385 pyruvate epimerase: endodeoxyribonuclease HR45_RS01890 HR45_RS18370 a 5-methylcytosine 967 a malonyl- a [protein]- an (1,5)- LptF FabG: fabG synthase 2: thr L-selenocysteine glutamate-5- phosphoribosylanthranilate hydroxyphenyl) homoserine HR45_RS10860 gly BioB: bioB HR45_RS07245 myo-inositol myo-inositol sulfite reduced riboflavin -glycerol 3- kinase: pyk HR45_RS00820 resolution of recombinationalRuvC: ruvC semialdehyde in 16S rRNA [BryP acyl- tetrahydrolycopene L-histidine L-arabinan 3-oxoacyl-ACP HR45_RS17810 low-specificity biosynthesis I (bacteria) semialdehyde cystathionine gamma- isomerase TrpF: trpCF pyruvate dehydrogenase TatB phosphate L-homocysteine synthase: metB aspartate/ D-xylulose a holo-[LYS2 L- junction formation carrier protein] reductase 1-acyl-sn-glycerol- ilvM L-threonine dehydrogenase: 1-(2-carboxyphenylamino)-1- aspartate/ II: HR45_RS00475 tyrosine/aromatic pyruvate biotin 5'-deoxyadenosine an unsulfurated maltopentaose maltose a (2R)-2- a halide anion ssDNA/pppN(pN) sec 5-phosphate met 3',5'-ADP 2-aminoadipyl- of two intact strands FabG: fabG (S)-2-aceto-2- aldolase: ltaE ser a tRNA HR45_RS14020 deoxy-D-ribulose 5-phosphate tyrosine/aromatic [sulfur carrier] hydroxy fatty acid hybrid 3-phosphate 5-methyltetrahydropteroyltriglutamate- bifunctional aminotransferase: L-cysteine biosynthesis I carrier-protein] n -1 hydroxybutanoate gly L-cystathionine aminotransferase: a (3R)-3- acyltransferase: glutamate-5- methionine - homocysteine S- bifunctional indole-3-glycerol- aspartate kinase/ HR45_RS02745 selenide HR45_RS10860 A(H2) thiosulfate RS17920 hydroxyhexadecanoyl-[acp] HR45_RS04350 ketol-acid semialdehyde synthase: metH methyltransferase: metE phosphate synthase TrpC/ homoserine serine- aspartate/ an N-acetyl-β- 745 a [protein]- reductoisomerase: dehydrogenase: phosphoribosylanthranilate dehydrogenase phe ser lysine within an (R)-2- 3-heptaprenyl-4- 3-decaprenyl-4- a guanine 2+ TtrA bifunctional 3- 1-acyl-sn-glycerol- -tRNA selenide, [+ 3 isozymes] cystathionine beta- methanethiol O-acetyl-L- D-glucopyranose a maltodextrin maltotriose a glucan chlorobactene chloramphenicol Ins(5)P N τ -phospho- ferulate Fe ilvC HR45_RS13220 isomerase TrpF: trpCF tyrosine/aromatic I: thrA gcv protein H an octanoyl-[acp] halocarboxylate D-hexosaminide hydroxybenzoate hydroxybenzoate in 23S rRNA ser hydroxydecanoyl- 3-phosphate ligase: water lyase: HR45_RS04385 Inorganic Nutrient Metabolism homoserine L-histidine A tetrathionate (R)-2,3-dihydroxy- aminotransferase: serine O- 4-hydroxy-3- 4-hydroxy-3- 23S rRNA carotenoid chloramphenicol inositol-1- phenolic acid ACP dehydratase/ acyltransferase: serS dikinase L-glutamate-5- met (1S,2R)-1-C-(indol-3- phosphohistidine bacterioferritin: bfr L-serine 3-methylpentanoate alanine HR45_RS02745 L-homoserine acetyltransferase: 4-alpha- 4-alpha- beta-N- polyprenylbenzoate polyprenylbenzoate (guanine(745)-N(1)) 1,2-hydratase: acetyltransferase: monophosphatase: decarboxylase: trans-2- HR45_RS09595 SelD: selD semialdehyde yl)glycerol 3-phosphate O-acetylhomoserine lipoyl(octanoyl) HAD family phosphatase bacterioferritin: bfr ammonia-lyase: a 1,2-diacyl- racemization L-homocysteine 2-aminoprop-2-enoate cysE superpathway of sulfate assimilation and cysteine biosynthesis glucanotransferase: glucanotransferase: acetylhexosaminidase: decarboxylase: ubiD decarboxylase: ubiD -methyltransferase: HR45_RS01600 HR45_RS04455 suhB HR45_RS07570 decenoyl-ACP dihydroxy-acid selenate reduction assimilatory aminocarboxypropyltransferase/ transferase hydrolase: SixA: sixA HR45_RS18500 TatA an L-seryl- tyr malQ malQ nagZ 1 rlmA sn-glycerol tryptophan homoserine HR45_RS01890 an N - chloramphenicol 3+ dehydratase: sec selenophosphate sulfate reduction IV cysteine synthase: HR45_RS04890 LipB: lipB 2-heptaprenylphenol 2-decaprenylphenol 1-hydroxychlorobactene a [protein]- 4-vinylguaiacol Fe isomerase: fabA [tRNA ] O-acetyl-L-serine 745 myo-inositol pyruvate 3-phosphate ilvD ala 5-methyltetrahydropteroyltriglutamate- synthase: trpB trpA kinase: thrB hydrogen sulfide 3-phospho-D-glycerate methylguanine 3-acetate L-histidine 3-hydroxyacyl- - homocysteine S- sulfate selenate an N-acetyl-β- in 23S rRNA (3S)-3-methyl-2- alanine (S)-1-pyrroline- L-glutamate ser O-phospho- sulfate sulfate a maltodextrin maltose a [glycine-cleavage a glucan D-glucopyranose a (2R)-2- ACP dehydratase L-seryl-tRNA(Sec) methyltransferase: metE indole phosphoglycerate acetate a halide anion an alcohol D-hexosamine oxopentanoate racemase: 5-carboxylate biosynthesis III 2-iminopropanoate L-homoserine O-acetylhomoserine sulfate adenylyltransferase: sulfate met acyl-carrier protein complex H protein] hydroxy fatty acid FabZ: fabZ selenium [+ 3 isozymes] dehydrogenase: serA 6 a CDP- branched-chain alr pyrroline-5- aminocarboxypropyltransferase/ adenylyltransferase: cysN cysD adenylyltransferase: N -octanoyl-L-lysine D-ala transferase: threonine adenosine 5'- a (2E)-hexadec-2-enoyl-[acp] diacylglycerol amino acid carboxylate 2-oxoglutarate tryptophan cysteine synthase: HR45_RS04890 cysN cysD cysN cysD HR45_RS00700 glutamate met synthase: trpB trpA synthase: 3-phosphooxypyruvate phosphoselenate APS aminotransferase: reductase: [+ 2 isozymes] 2457 (2E)-2- synthase large thrC a plant soluble N,N',N''- S-(2-hydroxyacyl) uridine a 4-hydroxy-3- a double 2-deoxy-D-ribose HR45_RS13795 HR45_RS02345 APS 3-phosphoserine/ Reactive Blue 5 D-glucopyranose coenzyme A an apo-[aryl- glutathionylspermidine 1-hydroxyneurosporene Ins(4)P ethanol γ-carotene hydroxypenta- an L- subunit: gltB pyruvate adenylyl-sulfate heteroglycan triacetylchitotriose glutathione in 23S rRNA polyprenylbenzoate thr stranded DNA 5-phosphate phosphohydroxythreonine carrier protein] 2,4-dienoate 1-(3-sn- selenocysteinyl- trp thr adenylyl-sulfate kinase: cysC 23S rRNA 4-hydroxy-3- L-threonine 3- carotenoid DNA/RNA inositol-1- magnesium- carotenoid ile sec pro glu cys transaminase: serC thiosulfate oxidation III (multienzyme complex) catalase: phosphatidyl) [tRNA ] kinase: cysC selenite 4-alpha- beta-N- pseudouridine(2457) polyprenylbenzoate dehydrogenase: tdh 1,2-hydratase: nuclease monophosphatase: dependent 1,2-hydratase: tautomerase Dyp-type holo-ACP bifunctional HR45_RS01655 a palmitoyl-[acp] -sn-glycerol Aminoacyl-tRNA Charging PAPS glucanotransferase: acetylhexosaminidase: hydroxyacylglutathione synthase RluE: rluE decarboxylase: ubiD HR45_RS01600 SfsA: sfsA suhB phosphatase-1: HR45_RS01600 PptA: pptA O-phospho-L-serine peroxidase: synthase: glutathionylspermidine L-threonine 3-phosphate PAPS a [SoxY protein]-L-cysteine malQ nagZ hydrolase: gloB a pseudouridine 2457 a 2-(all-trans- 1,1'-dihydroxy- HR45_RS04680 1'-hydroxy- phosphoadenylyl- HR45_RS02095 HR45_RS07245 amidase/synthase: gss dehydrogenase: yiaY a 5'-phosphooligonucleotide myo-inositol acetaldehyde 2-oxopent- phosphatidylglycerophosphatase tRNA charging in 23S rRNA polyprenyl)phenol neurosporene 2-deoxy-D-ribose γ-carotene phosphoadenylyl- phosphoserine sulfate reductase: aminoacetone 4-enoate A: HR45_RS18050 3-[(4-amino-6-chloro- a plant soluble N,N'- N-acetyl-D- a 2-hydroxy sulfate reductase: phosphatase SerB: serB selenodiglutathione HR45_RS01410 2,2'-disulfonyl maltose glutathione an L-1- 1,3,5-triazin-2-yl) phthalate heteroglycan 3',5'-ADP a holo-[aryl- diacetylchitobiose glucosamine glutathione spermidine carboxylate phe a tRNA Phe gly a tRNA Gly thr a tRNA Thr asn tRNA Asn elongator tRNA Met met initiator tRNA Met met cys a tRNA Cys gln a tRNA Gln his a tRNA His tyr a tRNA Tyr arg a tRNA Arg tRNA asp asp glu a tRNA glu val a tRNA Val ile a tRNA Ile trp a tRNA Trp pro a tRNA Pro HR45_RS01410 azobenzene palmitate phosphatidyl- a [SoxY protein]-S- sulfite amino]benzenesulfonate carrier protein] Ala ala lys Lys ser ser leu Leu sn-glycerol a tRNA a tRNA a tRNA a tRNA sulfite ser sulfosulfanyl-L-cysteine long-chain-fatty- phenylalanine- glycine-- threonine- asparagine- methionine- methionine- cysteine- glutamine- histidine- tyrosine-- arginine- aspartate- glutamate- valine-- isoleucine- tryptophan- proline-- acid--CoA ligase assimilatory sulfite serine O- an L-1- an (S-diacyl-sn- D-threo-7,8- adenine 1518 / uridine 2605 a uridine 516 (2R,3S)-3- D-ribose 5- -tRNA ligase: tRNA ligase: -tRNA -tRNA -tRNA -tRNA -tRNA -tRNA -tRNA tRNA ligase: -tRNA -tRNA -tRNA tRNA ligase: -tRNA -tRNA tRNA ligase: glutathioselenol D-glucopyranose maltotetraose coenzyme A AsbD acyl- dihydrolipoamide citrate 1-hydroxyneurosporene rhodopin MeOH β-D-fructofuranose 7,8-dihydropterin FadD: fadD alanine--tRNA lysine--tRNA serine--tRNA leucine--tRNA reductase (NADPH): glyceryl)-L-cysteinyl- 1519 phosphate acetyltransferase: cysE cytochrome c: phosphatidylethanolamine carrier protein dihydroneopterin adenine in 16S rRNA in 23S rRNA in 16S rRNA isopropylmalate long-chain fatty pheT pheS glyS glyQ ligase: thrS ligase: asnS ligase: metG ligase: metG ligase: cysS ligase: glnS ligase: hisS ligase: alaS HR45_RS07420 ligase: argS ligase: lysS ligase: serS ligase: aspS ligase: gltX HR45_RS12635 ligase: ileS ligase: leuS ligase: trpS HR45_RS18100 HR45_RS01400 cysI hydrogen sulfide [apolipoprotein] dihydrolipoyllysine- 16S rRNA bifunctional magnesium- HR45_RS00455 23S rRNA 16S rRNA carotenoid 3-isopropylmalate carotenoid fructokinase: guanine acid--CoA ligase: residue acetyltransferase: (adenine(1518)-N(6)/ aconitate hydratase dependent catalase: O-acetyl-L-serine 4-alpha- pseudouridine(2605) pseudouridine(516) 1,2-hydratase: dehydrogenase: 1,2-hydratase: mak deaminase: HR45_RS16915 an L-phenylalanyl- an L-asparaginyl- an L-methionyl- an L-methionyl- an L-glutaminyl- an L-tryptophanyl- hydrogen sulfide cytochrome c: holo-ACP HR45_RS03095 dihydroneopterin adenine(1519)-N(6))- 2/2-methylisocitrate phosphatase-1: HR45_RS01655 a glycyl-[tRNA Gly ] an L-threonyl-[tRNA Thr ] an L-cysteinyl-[tRNA Cys ] an L-histidyl-[tRNA His ] an L-alanyl-[tRNA Ala ] an L-tyrosyl-[tRNA Tyr ] an L-arginyl-[tRNA Arg ] an L-lysyl-[tRNA Lys ] an L-seryl-[tRNA ser ] an L-aspartyl-[tRNA asp ] an L-glutamyl-[tRNA Glu ] an L-valyl-[tRNA Val ] an L-isoleucyl-[tRNA Ile ] an L-leucyl-[tRNA Leu ] an L-prolyl-[tRNA Pro ] apolipoprotein N- glucanotransferase: synthase RluB: rluB synthase RsuA: rsuA HR45_RS01600 leuB HR45_RS01600 guaD Phe Asn Met Met Gln Trp a [SoxY protein]-HR45_RS07855S- a [SoxY protein]-S [tRNA ] [tRNA ] [elongator tRNA ] [initiator tRNA ] [tRNA ] [tRNA ] acyltransferase: lnt malQ synthase: dihydrolipoyllysine-residue aldolase: folB dimethyltransferase a pseudouridine 2605 a 16S rRNA dehydratase: acnB all-trans 4-methyl-2- HR45_RS04680 7,8- palmitoyl-CoA hydrogen selenide disulfanyl-L-cysteine -sulfanyl-L-cysteine all-trans-lycopene formaldehyde F6P O-acetylhomoserine HR45_RS07245 acetyltransferase: aceF 6 RsmA: rsmA1518 516 D-threo-isocitrate aldehydo-D-ribose urea cycle N -dimethyladenine in 23S rRNA pseudouridine neurosporene oxopentanoate dihydrolumazine aminocarboxypropyltransferase/ S-acetyldihydrolipoamide 6 1519 a 2-acyl-1-lyso- an N-acyl-(S-diacyl- 6-(hydroxymethyl) /N -dimethyladenine cysteine synthase: HR45_RS04890 maltose maltotriose glycolaldehyde phosphatidylethanolamine sn-glyceryl)-L- 3',5'-ADP a holo-[AsbD acyl- -7,8-dihydropterin in 16S rRNA [+ 2 isozymes] arg cysteinyl-[lipoprotein] carrier protein] assimilatory sulfate reduction III a [SoxY protein]-S-(2- ammonium cys 3-methyl-2- 5,10-methylene- a long-linear a 23S rRNA 3-nonaprenyl-4- a uridine 65 phosphoenol argininosuccinate seleno-L- coenzyme A [EntB aryl- a uridine in tRNA α-D-glucopyranose an α-limit dextrin 2-phosphoglycolate a thiopurine D-threo-isocitrate trans-caffeate 4-coumarate D-sedoheptulose sulfate sulfodisulfanyl)-L-cysteine α-D-glucan 1911/1915/1917 nitrate lyase: argH glutamine- oxobutanoate tetrahydromethanopterin homocysteine carrier protein] uridine hydroxybenzoate in tRNA pyruvate sulfate 5-methyltetrahydropteroyltriglutamate- tRNA dihydrouridine(16) 23S rRNA 4-hydroxy-3- 4-alpha- tRNA phosphoglycolate thiopurine S- isocitrate phenolic acid phenolic acid reduction IV adenylyltransferase: hydrolyzing fructokinase: pyruvate 3-methyl-2-oxobutanoate - homocysteine S- synthase DusC: dusC 4-alpha- pseudouridine(1911/ polyprenylbenzoate glucanotransferase: pseudouridine(65) phosphatase: methyltransferase: dehydrogenase: decarboxylase: decarboxylase: (dissimilatory) cysN cysD carbamoyl- mak kinase: pyk L-arginino- hydroxymethyltransferase: methyltransferase: metE holo-ACP tRNA dihydrouridine glucanotransferase: 1915/1917) decarboxylase: ubiD malQ synthase TruC: truC HR45_RS17275 HR45_RS00280 HR45_RS06900 HR45_RS07570 HR45_RS07570 nitrate APS L-ornithine phosphate synthase: a α-limit dextrin polyphosphate metabolism succinate panB [+ 2 isozymes] synthase DusB: dusB malQ synthase RluD: rluD a pseudouridine 65 a thiopurine 3,4- D-sedoheptulose sulfur synthase: a pseudouridine 1911/ HR45_RS07245 a 5,6-dihydrouridine in tRNA 2-nonaprenylphenol with short branches glycolate 2-oxoglutarate 4-vinylphenol 1-phosphate pyruvate reduction II (via phosphoadenylyl- carA carB SeMet 1915/1917 in 23S rRNA in tRNA S-methylether dihydroxystyrene polysulfide) sulfate reductase: long chain a short 1,4- carbamoyl nitrite HR45_RS01410 polyphosphate 2-dehydropantoate THMPT a holo-[EntB aryl- α-D-glucan S 0 3',5'-ADP argininosuccinate ornithine phosphate carrier protein] cytochrome sulfite synthase: carbamoyltransferase: c nitrite exopolyphosphatase: HR45_RS17745 HR45_RS17740 a polysulfide reductase assimilatory sulfite polyphosphate HR45_RS13880 L-citrulline 6 a generic an N -L- a 5-carboxymethylaminomethyluridine 34 a pseudouridine 1915 a single UDP-4-amino-4-deoxy- dCMP a uridine 13 (2R,3S)-3- UTP D-mannitol subunit reductase (NADPH): kinase 1: ppk1 37 coenzyme A [EntF L-seryl- β N-ethylmaleimide D-glucopyranose ribulose D-ribofuranose exopolyphosphatase: polynucleotide substrate threonylcarbamoyladenine in tRNA Leu in 23S rRNA stranded DNA -L-arabinopyranose in tRNA isopropylmalate 1-phosphate polysulfide NrfD: nrfD HR45_RS01400 cysI carrier protein] UDP-4-amino-4, 6- anaerobic HR45_RS05540 in tRNA tRNA (cytidine(34) 23S rRNA 5'-deoxynucleotidase: tRNA 3-isopropylmalate glucose 1- hexitol reductase tRNA cyclic N6- dideoxy-N-acetyl- ribulokinase: ribokinase: ribonucleoside- hydrogen sulfide thiosulfate -2'-O)- (pseudouridine(1915)- deoxyribonuclease yfbR pseudouridine(13) alkene reductase: dehydratase: dehydrogenase: phosphatase NrfD: nrfD ammonium threonylcarbamoyladenosine(37) beta-L-altrosamine HR45_RS00815 HR45_RS14795 triphosphate disproportionation S1/P1 nuclease: holo-ACP methyltransferase: N(3))-methyltransferase IV: nfo synthase TruD: truD HR45_RS11005 leuD leuC HR45_RS16965 HxpB: hxpB long chain synthase TcdA: tcdA transaminase: pseC 2'-deoxycytidine reductase: nrdD IV (rhodanese) HR45_RS14850 6 synthase: HR45_RS09390 RlmH: rlmH 13 L(or D)-ribulose D-ribofuranose a polysulfide sulfide oxidation II a cyclic N -L- an N 3 - UDP-β-L-threo- a pseudouridine (2S)-2- D-glucono- polyphosphate HR45_RS07245 a 5-carboxymethylaminomethyl- a 5'-phosphooligonucleotide N-ethylsuccinimide dUTP D-mannitol thiosulfate threonylcarbamoyladenosine 1915 in tRNA isopropylmalate 1,5-lactone 5-phosphate 5-phosphate (flavocytochrome c) 2'-O-methyluridine 34 in tRNA Leu methylpseudouridine pentapyranos-4-ulose 37 in tRNA a holo-[EntF in 23S rRNA nitrogen fixation hydrogen sulfide a 5'-phosphomononucleotide a 5'-phosphooligonucleotide thiosulfate 3',5'-ADP L-seryl-carrier I (ferredoxin) flavocytochrome sulfurtransferase protein] c: HR45_RS10405 N GlpE: glpE 2 flavocytochrome nitrogenase 2,5-diamino-6-(5- UDP-2-acetamido-4-amino- N,N'- 55 c: HR45_RS07115 phosphatidylglycerolphosphate 38-40 a double dUMP a uridine D-sedoheptulose dTMP β CTP D-sorbitol iron protein: nifH 0 a uridine in tRNA α uroporphyrinogen-I D-glucopyranose GDP- -L-fucose cellulose thiocyanate sulfite S phospho-D-ribitylamino) stranded DNA 2,4,6-trideoxy- -D-galactose diacetylchitobiose in tRNA 7-phosphate 6-phosphate (1-oleoyl, 2-palmitoyl) UDP-4-amino-4, 6- anaerobic [+ 2 isozymes] pyrimidin-4(3H)-one RluA family pseudouridine beta-N- 5'-deoxynucleotidase: tRNA phosphoheptose 5'-deoxynucleotidase: glucose 1- GDP-L-fucose hexitol ammonium bifunctional dideoxy-N-acetyl- endoglucanase: ribonucleoside- phosphatidylglycerophosphatase synthase: HR45_RS11850 exodeoxyribonuclease uroporphyrinogen acetylhexosaminidase: yfbR pseudouridine(55) isomerase: yfbR dehydrogenase: synthase: phosphatase diaminohydroxyphosphoribosylaminopyrimidine beta-L-altrosamine HR45_RS11170 triphosphate A: HR45_RS18050 tRNA pseudouridine(38- V: recC recB recD decarboxylase: hemE nagZ synthase TruB: truB HR45_RS17290 HR45_RS16965 HR45_RS13405 HxpB: hxpB deaminase/5-amino-6-(5-phosphoribosylamino) transaminase: pseC 2'-deoxyuridine thymidine reductase: nrdD 40) synthase TruA: truA N-acetyl-D- 55 GDP-4-dehydro- uracil reductase RibD: ribD 1-oleoyl-2-palmitoyl- UDP-2-acetamido-2,6- a pseudouridine D-glycero-D-manno- D-glucono- a cellodextrin dCTP D-sorbitol 38-40 a 5'-phosphooligonucleotide coproporphyrinogen I glucosamine α-D-rhamnose 5-amino-6-(5-phospho- phosphatidylglycerol a pseudouridine in tRNA dideoxy-α-D-xylo-hex-4-ulose in tRNA heptose 7-phosphate 1,5-lactone Detoxification D-ribitylamino)uracil

arsenate arsenate reactive oxygen species degradation arsenate 8-oxo-(d)GTP detoxification I arginine detoxification detoxification detoxification V dependent II (glutaredoxin) III (thioredoxin) superoxide acid resistance arsenate arsenate arsenate dGTP GTP arsenate reductase arsenate superoxide glyceraldehyde- arg (glutaredoxin): arsC reductase dismutase [Fe]: sodB 3-phosphate biosynthetic (glutaredoxin) dehydrogenase: arginine arsenate reductase: 8-oxo-dGTP 8-oxo-GTP : arsC hydrogen peroxide HR45_RS02960 decarboxylase: HR45_RS03380 1-arseno-3- arsenite arsenite 8-oxo-dGTP speA phosphoglycerate agmatine catalase: diphosphatase HR45_RS01655 MutT: mutT 8-oxo-GMP H O hydroxyl radical 8-oxo-dGMP 2 1-arseno-3- arsenite arsenite O 2 phosphoglycerate

ammonium ammonium

RarD FtsW RS14790 PstA RS03490 RS07190 DjlA RS05855 RS05745 SstT RS15820 TolQ RS05560 CorA FliN FliR RS05505 RseP RS13455 RS07480 RS01935 RS17620 RS09705 SecD RS09675 RS01455 RS01300 RS01440 NhaB RS01085 RS00940 FliR RS09565 RS00460 RS00320 LptB RS11670 RS09455 RS09495 SecY MlaE RsxA RS06480 RS05320 FliP YidC RS02040 RS13125 RS06535 RS01355 CcmE SecF RS01615 RS17600 RS01895 RS08720 RS02175 RS10035 RS02460 FlhA FliP FliL RS05250 ChrA RS10340 RS08770 PomA RS08910 RS07960 GspK RS03360 SecG FtsY RodA CcmB RS08800

ammonium ammonium

This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.